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Дисертації з теми "Therapeutic and diagnostic tactics"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Chabok, Abbas. "Colonic Diverticulitis : Diagnostic and Therapeutic Aspects." Doctoral thesis, Uppsala universitet, Centrum för klinisk forskning, Västerås, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-168282.

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The overall aims of this thesis were to evaluate diagnostic and therapeutic aspects of colonic diverticulitis. In the first study, a systematic review of the literature was performed to evaluate radiological diagnostics for patients with acute left-sided diverticulitis. Forty-nine relevant articles were found and read in full and data were extracted or calculated. Twenty-nine of these were excluded. The best evidence for the diagnosis of diverticulitis in the literature was to be found with US. Only one small study of good quality was found for both CT and MRI. In the second paper, a prospecti

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2

Appleyard, Mark Neil. "Innovations in diagnostic and therapeutic endoscopy." Thesis, Queen Mary, University of London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404420.

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3

Fornara, Andrea. "Multifunctional nanomaterials for diagnostic and therapeutic applications." Doctoral thesis, KTH, Funktionella material, FNM, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-26788.

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In the past few years, the use of nanostructured materials in medical applications hasdramatically increased, both in the research phase and for clinical purposes, due to thepeculiar properties and the ability of such materials to interact at a similar scale withbiological entities. In this thesis, we developed tailored magnetic multifunctionalnanoparticles for diagnostic and therapeutic applications, such as detection ofbiomolecules, simultaneous enhanced magnetic resonance imaging (MRI), fluorescentvisualization and controlled drug release.For sensitive and selective detection of specific bi

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4

Vissers, Marieke. "Diagnostic and therapeutic protocols in medical practice." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1996. http://arno.unimaas.nl/show.cgi?fid=6648.

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5

Finlayson, Sarah E. "Congenital myasthenic syndromes : current diagnostic and therapeutic aspects." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:5e08ab86-8a20-48b3-86b9-683eb8b2c6e4.

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6

Khan, Tanweera S. "New Diagnostic and Therapeutic Approaches in Adrenocortical Cancer." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4243.

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7

Md, Tohid Siti Farah. "Synthesis of potential cancer therapeutic and diagnostic agents." Thesis, Cardiff University, 2011. http://orca.cf.ac.uk/54438/.

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The need to find novel anticancer agents with better potency, efficacy and safety are highly demanded. Therefore, the first part of the study was aimed to synthesise new compounds based on stilbenes, indole-based isoxazoles and tricyclic anilides as potential antitumour agents, which later will be evaluated for their anticancer properties. The syntheses of substituted stilbenes were achieved via catalyzed or uncatalyzed methods, yielding stilbene analogues in moderate to good yields. Preliminary antiproliferative studies on four cancer cell lines (prostate, non-small lung, colon and breast) de

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8

Simmons, Suzanne Clare. "Development of Aptamers as Diagnostic and Therapeutic Agents." Thesis, Open University, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.524784.

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9

Raïs, Ali Setti. "Diagnostic and therapeutic odyssey : essays in health economics." Thesis, Paris 1, 2019. http://www.theses.fr/2019PA01E019/document.

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Cette thèse de doctorat met l’emphase sur les défis rencontrés par les patients atteints de maladies rares. Elle est structurée en trois parties, chacune d’entre elles dédiée aux enjeux d’un acteur au cœur de l’Odyssée diagnostique et thérapeutique des patients atteints de maladies rares. La première partie de la thèse s’intéresse au patient et à son réseau social. Le chapitre 1 considère les sources de délai à l’accès au diagnostic, et explore notamment l’effet du capital social sur le délai d’obtention du diagnostic. Le chapitre 2 évoque les externalités négatives sur la santé maternelle d’u

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10

Lindbäck, Stefan. "Primary HIV-1 infection : diagnostic, prognostic, and therapeutic aspects /." Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3606-4/.

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11

Bernardi, Enrico. "Diagnostic and therapeutic management of venous and arterial disease." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2003. http://dare.uva.nl/document/68083.

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12

Yu, Feifan. "Generating Affinity Proteins for Biotechnological, Diagnostic and Therapeutic Applications." Doctoral thesis, KTH, Proteinteknologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-164320.

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Protein engineering is a powerful tool to modify proteins to generate novel and desired properties that could be applied in biotechnological, diagnostics and therapeutic areas. In this thesis, both rational design and library based engineering principles have been exploited to develop affinity proteins with desired traits. One study was focused on the use of site-directed mutagenesis to obtain variants of the staphylococcal protein A-derived 58-residue immunoglobulin binding Z domain with improved affinity for mouse IgG1 Fc. Screening of ca. 170 constructed variants revealed one variant with a

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13

Kay, Richard D. "Complexes of functionalised polyamines with diagnostic and therapeutic applications." Thesis, University of Nottingham, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342468.

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14

Chortis, Vasileios. "Developing new diagnostic and therapeutic approaches in adrenocortical carcinoma." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7525/.

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Adrenocortical carcinoma (ACC) is an aggressive malignancy with high recurrence rates and poor response to chemotherapy. With this work, we have evaluated a potential new treatment target focusing on the mitochondrial NADPH generator Nicotinamide Nucleotide Transhydrogenase (NNT). NNT has a central role within the mitochondrial antioxidant pathways, which protect cells from oxidative stress. Our hypothesis was that NNT silencing will expose cells to cytotoxic levels of oxidative stress. We knocked down NNT transiently in NCJ-H295R ACC cells in vitro; this led to an increase in cellular oxidati

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15

Chapman, P. J. "Diagnostic, prognostic and therapeutic considerations in primary pulmonary hypertension." Master's thesis, University of Cape Town, 1987. http://hdl.handle.net/11427/25726.

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The diagnosis of primary pulmonary hypertension (PPH) and prediction of its course, whether treated or untreated, presents several problems. These are of particular relevance when selection of patients for, and timing of heart-lung transplantation is being considered. I performed a retrospective study on patients with PPH and chronic large vessel thromboembolic pulmonary hypertension (TPH) seen at Groote Schuur Hospital between 1957 and 1985 in an attempt to: 1. Establish the diagnostic and prognostic value of clinical features, lung function tests, cardiac catheterisation, isotope lung scans

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16

Deosarkar, Sudhir P. "Development of Novel Therapeutic and Diagnostic Approaches for Atherosclerosis." Ohio University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1268371885.

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17

Abel, Mark Joshua. "Novel therapeutic and diagnostic ultrasound techniques in cancer management." Thesis, Imperial College London, 2016. http://hdl.handle.net/10044/1/47909.

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Introduction: The aim of this thesis is to assess novel therapeutic and diagnostic ultrasound techniques in cancer management. A drive to improve prognosis in cancer patients has resulted in a vast array of recent medical advances and new approaches using ultrasound technology may enhance outcome in patients with a diagnosis of malignancy. Methods: A new 256 element random phased-array high intensity focused ultrasound (HIFU) device was designed, developed and tested for use in treating hepatic tumours. An existing intra-cavitary HIFU transducer (Sonablate 500®) currently under investigation f

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18

BERZERO, GIULIA. "“MOLECULAR MARKERS IN DIFFUSE GLIOMAS: DIAGNOSTIC AND THERAPEUTIC TARGETS”." Doctoral thesis, Università degli studi di Pavia, 2020. http://hdl.handle.net/11571/1371676.

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Due to their capital diagnostic, prognostic and therapeutic implications, molecular markers have become essential for the management of patients with diffuse gliomas. Among them, IDH mutations have special importance, as they allow to classify diffuse gliomas, they are predictive of prolonged survival and increased sensitivity to alkylating agents and can be targeted by specific inhibitors. IDH-mutant diffuse gliomas deeply differ from IDH-wildtype diffuse gliomas in terms of molecular profile, prognosis and treatment, as different are the pathways of gliomagenesis and progression in the two g

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19

Cabré, Casares Noemí. "Assessing Diagnostic and Therapeutic Targets in Obesity-Associated Liver Diseases." Doctoral thesis, Universitat Rovira i Virgili, 2019. http://hdl.handle.net/10803/667718.

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Les alteracions hepàtiques, com la malaltia del fetge gras no alcohòlic (NAFLD) i l'esteatohepatitis no alcohòlica, o NASH, s'associen freqüentment amb l'obesitat. L'absència de marcadors no invasius per al diagnòstic de NASH dificulta la pràctica clínica i el desenvolupament de tractaments farmacològics. Per investigar els mecanismes moleculars d'aquestes alteracions i identificar les molècules que podrien usar-se com a possibles dianes terapèutiques, busquem marcadors biològics no invasius d'alteracions hepàtiques en pacients amb obesitat tipus III sotmesos a cirurgia bariàtrica (CB). En el

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20

Torres-Rojas, Esperanza. "Expression of diagnostic and therapeutic antibodies in crop plant systems." Thesis, University of East Anglia, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365010.

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21

Hull, E. A. "Antibody conjugates via disulfide bridging : towards therapeutic and diagnostic applications." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1461131/.

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Antibodies play a prominent role in chemical and biological research and the largest application of chemical bioconjugation reagents is in the production of antibody conjugates. These conjugates provide a means of highly sensitive detection, for example in enzyme-linked immunosorbent assay (ELISA) systems. In therapeutics, such conjugates have enabled the development of bispecifics and antibody-enzyme directed prodrug therapy (ADEPT). Long-established chemical modification techniques for the conjugation of antibodies yield highly heterogeneous products. This heterogeneity is far from optimal a

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22

Al-Haj, Abdalla Noaman. "Hydrophilic materials as tissue substitutes for diagnostic and therapeutic modalities." Thesis, University of Surrey, 1996. http://epubs.surrey.ac.uk/843802/.

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The object of the study is to measure the photon mass attenuation coefficient of hydrophilic materials with the aim of investigating their suitability as tissue equivalent material. Two types of hydrophilic material were tested; the ED4C which has 72% water uptake by weight and the H-40 which has 40% water uptake by weight. Measurements were made for both types in dry and fully hydrated state. The measurements were obtained by using (a) narrow beam geometry and mono-energetic beams with a range of energies between 13.37 and 662 keV; (b) medical x-ray sources, used in diagnostic radiology such

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23

Овечкін, Денис Вячеславович, Денис Вячеславович Овечкин, Denys Viacheslavovych Ovechkin, O. M. Bulchenko, and A. A. Dennis. "Clinical-diagnostic and therapeutic features of acute appendicitis in children." Thesis, Sumy State University, 2014. http://essuir.sumdu.edu.ua/handle/123456789/36586.

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Acute appendicitis is the most frequent disease in childhood. It requires an emergency surgical intervention and has a number of features in comparison with adults. It is more severe, and diagnostics is more complex. This is due primarily to the large number of diseases occurring with pseudo abdominal syndrome, difficulties of inspection and revealing of local symptoms particularly in young children. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/36586

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24

Strandberg, Gunnar. "Experimental Studies on Diagnostic and Therapeutic Aspects of Intraosseous Access." Doctoral thesis, Uppsala universitet, Anestesiologi och intensivvård, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-321403.

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Reliable access to the circulation is paramount in most medical and surgical emergencies. When venous access cannot be expediently established, intraosseous (IO) access is indicated. This method has a high success rate even in relatively inexperienced hands and there is considerable clinical experience of IO administration of drugs and fluids. There is however limited evidence on the use of IO samples for laboratory analysis. Also, uptake of drugs during shock has not been extensively studied. Further, there have been concerns that analysis of IO samples may damage laboratory equipment. We hav

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25

Haycock, Adam Vaughan. "Quality assurance of training in diagnostic and therapeutic gastrointestinal endoscopy." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/6069.

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Previous evidence has shown that standards of performance in gastrointestinal endoscopy are variable and that there are disparities in training outcomes. Many changes have been made recently to both training and assessment of endoscopy in the UK. However, no prospective methods of evaluating their outcome have been put in place. The aims of this research were to evaluate current and new training processes and assessments in order to quality assure the outcomes and improve the training process. Two audits were undertaken demonstrating improvements in colonoscopy training over 5 years within a s

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26

Phipps, Paul R. (Paul Robert). "Characterisation and pulmonary deposition of therapeutic and diagnostic aqueous aerosols." Phd thesis, Department of Pharmacy, 1990. http://hdl.handle.net/2123/6645.

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27

Workman, R. W. "The development candidate therapeutic and diagnostic ligands for prion diseases." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/49078/.

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To date there are no effective treatments for prion diseases, and these diseases are always fatal in both humans and animals. Additionally, the gold standard for diagnosis of these disease remains to be the analysis of biopsied brain tissue obtained post mortem. Consequently, there is a continued demand for therapeutics and ante-mortem diagnostics for prion diseases. This project addresses these demands by investigating candidate therapeutic and diagnostic ligands for prion diseases. This study investigated recombinant prion proteins (rPrPs) as inhibitors in scrapie and bovine spongiform encep

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28

Stewart, Rachel Christine. "A diagnostic imaging technique and therapeutic strategy for early osteoarthritis." Thesis, Boston University, 2014. https://hdl.handle.net/2144/12949.

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Thesis (Ph.D.)--Boston University<br>Osteoarthritis (OA) is a chronic, progressive disease of diarthrodial joints arising from the breakdown of articular cartilage. As one of the leading causes of disability and lifestyle limitations in the United States, osteoarthritis is estimated to affect 27 million people in the U.S. and cost the economy $128 billion annually. Current diagnostic techniques detect OA only in its later stages, when irreversible cartilage damage has already occurred. A reliable, non-invasive method for diagnosing OA in its early stages would provide an opportunity to interve

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29

Greco, Arianna <1987&gt. "Synthesis of constrained peptidomimetics for therapeutic, diagnostic and theranostic applications." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/7028/1/Greco_Arianna_Tesi.pdf.

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This thesis work deals, principally, with the development of different chemical protocols ranging from environmental sustainability peptide synthesis to asymmetric synthesis of modified tryptophans to a series of straightforward procedures for constraining peptide backbones without the need for a pre-formed scaffold. Much efforts have been dedicated to the structural analysis in a biomimetic environment, fundamental for predicting the in vivo conformation of compounds, as well as for giving a rationale to the experimentally determined bioactivity. The conformational analyses in solution has b

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30

Greco, Arianna <1987&gt. "Synthesis of constrained peptidomimetics for therapeutic, diagnostic and theranostic applications." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/7028/.

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This thesis work deals, principally, with the development of different chemical protocols ranging from environmental sustainability peptide synthesis to asymmetric synthesis of modified tryptophans to a series of straightforward procedures for constraining peptide backbones without the need for a pre-formed scaffold. Much efforts have been dedicated to the structural analysis in a biomimetic environment, fundamental for predicting the in vivo conformation of compounds, as well as for giving a rationale to the experimentally determined bioactivity. The conformational analyses in solution has b

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31

Kim, Hyun Pyo. "Strategies for improving the therapeutic and diagnostic approaches to acute leukemias." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/39633.

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Acute leukemia (AL) represents a hematological cancer originated from malignantly transformed myeloid or lymphoid precursors. Steady improvement in the prognosis of patients with AL has been observed over the last 30 years. However, the duration of remission has been still short and the overall survival of AL remains poor. Therefore, novel therapeutic strategies are necessary to enhance the cure rate and the quality of life. Although initial remissions can be obtained with tyrosine kinase inhibitor (TKI) in Ph⁺ AL, drug resistance develops and the responses are short-lived. I chose to study DT

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32

Ahsen, Osman Oguz. "Diagnostic and therapeutic devices and applications of endoscopic optical coherence tomography." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/117806.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2018.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Cataloged from student-submitted PDF version of thesis.<br>Includes bibliographical references (pages 154-171).<br>There is an increased demand for developing transformative technologies to satisfy unmet needs in the clinical management of a number of gastrointestinal (GI) tract diseases. With the maturation of sweptsource la

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33

Karalija, Amar. "Diagnostic and therapeutic strategies following spinal cord and brachial plexus injuries." Doctoral thesis, Umeå universitet, Anatomi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-127519.

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Traumatic injuries to the spinal cord and brachial plexus induce a significant inflammatory response in the nervous tissue with progressive degeneration of neurons and glial cells, and cause considerable physical and mental suffering in affected patients. This thesis investigates the effects of the antioxidants N-acetyl-cysteine (NAC) and acetyl-L- carnitine (ALC) on the survival of motoneurons in the brainstem and spinal cord, the expression of pro-apoptotic and pro-inflammatory cell markers, axonal sprouting and glial cell reactions after spinal hemisection in adult rats. In addition, a nove

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34

Nair, Amit. "Development of a targeted diagnostic and therapeutic delivery system for cholangiocarcinoma." Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/16791/.

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The current outcomes of peri-hilar cholangiocarcinoma (PH-CCA) are in general poor with no proven roles for any treatment modalities in improving survival apart from complete surgical extirpation. The dismal prognosis observed is contributed to by both delays in diagnosis and aggressive tumour biology. The advent of molecular targeting of solid cancers allows harnessing this property on microbubble and nanotechnology based platforms. Such a system provides for concurrent diagnosis and therapeutic effect (theragnosis), the feasibility of which is explored in this work. The expression of two can

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35

Kandanapitiye, Murthi S. "Synthesis of Biocompatible Nanoparticulate Coordination Polymers for Diagnostic and Therapeutic Applications." Kent State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=kent1429019837.

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36

Fuster, García Carla. "Therapeutic approaches and development of genomic diagnostic tools for Usher syndrome." Doctoral thesis, Universitat Politècnica de València, 2020. http://hdl.handle.net/10251/137034.

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[ES] El síndrome de Usher (USH) es un trastorno raro autosómico recesivo definido principalmente por sordera neurosensorial (SNHL), y una distrofia retiniana conocida como retinosis pigmentaria (RP). La patología muestra heterogeneidad genética, puesto que se conocen al menos 10 genes responsables. No obstante, las mutaciones en USH2A son la causa más frecuente de la enfermedad, en gran medida por la recurrencia de la variante patogénica c.2299delG. En esta tesis se ha desarrollado un ensayo de edición génica para revertir dicha anomalía genética por medio del sistema CRISPR/Cas9. Se diseñ

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37

Bagley, Alexander Francis. "Optically-Active Nanomaterials for Diagnostic and Therapeutic Applications in Ovarian Cancer." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11517.

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The clinical management of cancer has principally relied upon surgery, radiation therapy, and chemotherapy for many decades. Despite recent advances in molecularly-targeted diagnostic and therapeutic agents, the long-term survival rates in patients with solid malignancies including ovarian cancer have improved only incrementally. Nanotechnologies designed to locally interrogate and modulate the tumor microenvironment offer a promising opportunity to enhance existing treatment modalities and establish new therapeutic paradigms. By virtue of their elemental composition, geometry, and surface che

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38

Mazor, Yoav. "Exploring novel diagnostic and therapeutic strategies for disorders of anorectal function." Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/20850.

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Constipation and faecal incontinence (FI) are common gastrointestinal disorders, affecting 8-18% of the Western population. These disorders severely impact patients’ quality of life and are associated with a substantial financial burden on health systems. The diagnosis of both of these conditions relies on careful history taking, physical examination, including digital rectal examination, and anorectal physiological testing. When conservative management fails, anorectal biofeedback (BF) treatment is usually the treatment of choice. The aims of this work were to (1) improve the diagnostic algor

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39

Reimann, Sabine [Verfasser]. "Multivalent Dendritic Polyglycerol Anions for Diagnostic and Therapeutic Applications / Sabine Reimann." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1137206640/34.

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40

Morse, David Linn. "Choline metabolites as diagnostic and therapeutic response indicators for breast cancer." Diss., The University of Arizona, 2004. http://hdl.handle.net/10150/280525.

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Choline metabolites are elevated in breast cancer, decrease in response to effective therapy and are detected non-invasively by magnetic resonance modalities. Decreases in choline metabolites occur early-on after initiation of treatment. There is potential for use of choline metabolites as non-invasive diagnostic and therapeutic response indicators. Choline metabolites are detected in vivo by magnetic resonance spectroscopy (MRS) in broad resonances which are composites of multiple compounds. Tumor extract studies have suggested that phosphocholine (PCho) is the component of these resonances

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41

Svobodová, Markéta. "Selection of aptamers against prostate specific antigen for diagnostic and therapeutic applications." Doctoral thesis, Universitat Rovira i Virgili, 2012. http://hdl.handle.net/10803/83492.

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Actualmente, el antígeno prostático específico (PSA) se considera el marcador más sensible para la detección de cáncer de próstata. Hasta la fecha anticuerpos monoclonales y policlonales se han utilizado para detectar el PSA debido a su alta especificidad y sensibilidad. Sin embargo, la producción de anticuerpos es lenta y cara. En el otro lado, los aptámeros con especificidad y afinidad iguales a los de los anticuerpos podría ser una forma alternativa para la detección de PSA. El objetivo de este trabajo es la selección de aptámeros contra el PSA. Aspectos fundamentales como la caracteriza

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42

Sakr, Yasser. "Studies in patients with sepsis and organ failure: diagnostic and therapeutic aspects." Doctoral thesis, Universite Libre de Bruxelles, 2007. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210630.

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Sepsis et défaillances viscérales; aspects diagnostiques et thérapeutiques<p><p>Le sepsis est un problème fréquemment rencontré en unité de soins intensifs (USIs) avec une morbidité et une mortalité élevées. Comprendre les mécanismes physiopathologiques du sepsis est essentiel à la fois pour mieux déterminer les bénéfices et/ou les effets indésirables des thérapies déjà en cours et développer de nouvelles statégies thérapeutiques. Des études épidémiologiques offrent une vue d´ensemble sur l´importance de la mobidité et la mortalité liées au sepsis et permettent d’apporter un élément de réponse

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Georgoulia, Nefeli Eleonora. "In search of breast cancer cell secretions with therapeutic and diagnostic value." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11377.

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The first end point of this study was to identify specific pro-apoptotic or anti-proliferative factors in the breast cancer cell secretome. To this end, we designed an in vitro screen that effectively cross-cultured 20 breast cancer cell lines in each other's conditioned media. We selected the strongest pro-apoptotic hits and performed further proteomic and biochemical characterization in order to analyze their composition. We determined that the pro-apoptotic activity resided in the soluble, exosome-free secreted fraction of triple negative breast cancer cell conditioned medium and used prote

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44

Long, Sam Nicholas. "An investigation of telomerase-based diagnostic and therapeutic strategies in canine cancer." Thesis, University of Glasgow, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.437961.

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45

Åstrand, Mikael. "Engineering strategies for ABD-derived affinity proteins for therapeutic and diagnostic applications." Doctoral thesis, KTH, Proteinteknologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-186279.

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Small stable protein domains are attractive scaffolds for engineering affinity proteins due to their high tolerance to mutagenesis without loosing structural integrity. The albuminbinding domain is a 5 kDa three-helix bundle derived from the bacterial receptor Protein G with low-nanomolar affinity to albumin. In this thesis, the albumin-binding domain is explored as a scaffold for engineering novel affinity proteins with the possible benefit of combining a prolonged serum half-life with specific targeting in a single small scaffold protein. Previously, a library was created by randomizing surf

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46

Mthiyane, Thuli Carol Penelope. "Diagnostic and therapeutic biomarker responses in HIV and tuberculosis co-infected patients." Doctoral thesis, Faculty of Health Sciences, 2020. http://hdl.handle.net/11427/32846.

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Introduction: Biomarkers of tuberculosis (TB) diagnosis and treatment response in patients coinfected with human immunodeficiency virus (HIV) are a necessity to ensure early diagnosis and adequate monitoring of TB treatment response. We conducted 3 sub-studies: study 1 was a bioavailability study; study 2 was a PK study in HIV-TB co-infected persons, and study 3 evaluated a WHO-recommended treatment algorithm in TB-HIV co-infected persons. Study 1 and 2 contributed to the study of 2 (NAT2) polymorphisms. Study 1 was leveraged to evaluate Quantiferon Gold in tube (QFT-GIT) and a quality of life

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Perera, Vindya S. "Synthesis and Characterization of Novel Inorganic Nanoparticles for Diagnostic and Therapeutic Applications." Kent State University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=kent1415976430.

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Watson, Christopher. "Towards new diagnostic and gene-based therapeutic approaches in the retinal dystrophies." Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/28503.

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Introduction Phosphodiesterase 6B (PDE6B) (OMIM: 180072) is one of the most commonly mutated genes causing autosomal recessive retinitis pigmentosa (RP), which leads to progressive visual loss. RP is the focus of this work, and is part of a group of diseases called the retinal dystrophies. This work aims to develop a disease model for RP caused by variants in PDE6B, using gene editing techniques in human induced pluripotent stem (iPS) cells that may be developed into retinal organoids as a model for approaches to investigate variants and to assess gene replacement therapy. The more detailed

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Gaspardo, Alba <1991&gt. "Canine chronic inflammatory enteropathies: diagnostic markers, endoscopic tecniques and novel therapeutic approaches." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amsdottorato.unibo.it/9696/1/Gaspardo_Alba_-_Tesi_dottorato_XXXIII_ciclo.pdf.

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Canine chronic inflammatory enteropathies (CIE) are a group of diseases characterized by chronic gastrointestinal (GI) symptoms. Once other causes for GI symptoms have been ruled out, subdivision of CIEs occurs through therapeutic response which involves a unique trial. The therapeutic steps include a dietary change, subsequently the introduction of antibiotic therapy (this step has recently been discouraged), the execution of an endoscopy of the digestive tract and the introduction of an immunosuppressive therapy. Understanding the pathogenesis and the type of CIE in is fundamental for a corr

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PRAMSTRALLER, Mattia. "The edentulous posterior ridge: novel diagnostic and therapeutic approaches for bone augmentation." Doctoral thesis, Università degli studi di Ferrara, 2018. http://hdl.handle.net/11392/2488163.

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