Увійти

Готові списки джерел за темами / Therapeutic potential of anticancer immunotoxins

Зміст

Статті в журналах

Добірка наукової літератури з теми "Therapeutic potential of anticancer immunotoxins"

Автор: Grafiati

Опубліковано: 11 березня 2023

Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями

Оберіть тип джерела:

Ознайомтеся зі списками актуальних статей, книг, дисертацій, тез та інших наукових джерел на тему "Therapeutic potential of anticancer immunotoxins".

Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.

Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.

Статті в журналах з теми "Therapeutic potential of anticancer immunotoxins"

1

Choudhary, Swati, Mrudula Mathew, and Rama S. Verma. "Therapeutic potential of anticancer immunotoxins." Drug Discovery Today 16, no. 11-12 (2011): 495–503. http://dx.doi.org/10.1016/j.drudis.2011.04.003.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

2

Ahmad, Zuhaida Asra, Swee Keong Yeap, Abdul Manaf Ali, Wan Yong Ho, Noorjahan Banu Mohamed Alitheen, and Muhajir Hamid. "scFv Antibody: Principles and Clinical Application." Clinical and Developmental Immunology 2012 (2012): 1–15. http://dx.doi.org/10.1155/2012/980250.

Повний текст джерела

Анотація:

To date, generation of single-chain fragment variable (scFv) has become an established technique used to produce a completely functional antigen-binding fragment in bacterial systems. The advances in antibody engineering have now facilitated a more efficient and generally applicable method to produce Fv fragments. Basically, scFv antibodies produced from phage display can be genetically fused to the marker proteins, such as fluorescent proteins or alkaline phosphatase. These bifunctional proteins having both antigen-binding capacity and marker activity can be obtained from transformed bacteria

Стилі APA, Harvard, Vancouver, ISO та ін.

3

Oszajca, Katarzyna, Łukasz Wieteska, Magdalena Cybula, and Janusz Szemraj. "The assessment of prokaryotic addictive modules’ activity in the context of seeking novel immunotoxins." Postępy Polskiej Medycyny i Farmacji 5 (June 26, 2017): 59–63. http://dx.doi.org/10.5604/01.3001.0011.6195.

Повний текст джерела

Анотація:

Despite of the fact that current anticancer chemotherapeutics have many beneficial achievements, there is an urgent need for new efficient therapies. A new type of drugs which are extensively investigated are immunotoxinshybrid proteins that consist of cytotoxic component and second part which is responsible for selective binding to the receptors on tumor cells. Unfortunately, this group of therapeutics still has many drawbacks. There is a strong demand for research on a new substances and develo-ping targeted therapy strategies. In the present study we tested VapC toxin derived from prokaryot

Стилі APA, Harvard, Vancouver, ISO та ін.

4

Stone, Marvin J. "Immunotoxins as Potential Anticancer Agents." Baylor University Medical Center Proceedings 3, no. 4 (1990): 35–37. http://dx.doi.org/10.1080/08998280.1990.11929736.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

5

Pincus, Seth H. "Therapeutic potential of anti-HIV immunotoxins." Antiviral Research 33, no. 1 (1996): 1–9. http://dx.doi.org/10.1016/s0166-3542(96)00995-3.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

6

Kawakami, Koji, Oumi Nakajima, Ryuichi Morishita, and Ryozo Nagai. "Targeted Anticancer Immunotoxins and Cytotoxic Agents with Direct Killing Moieties." Scientific World JOURNAL 6 (2006): 781–90. http://dx.doi.org/10.1100/tsw.2006.162.

Повний текст джерела

Анотація:

Despite the progress of the bioinformatics approach to characterize cell-surface antigens and receptors on tumor cells, it remains difficult to generate novel cancer vaccines or neutralizing monoclonal antibody therapeutics. Among targeted cancer therapeutics, biologicals with targetable antibodies or ligands conjugated or fused to toxins or chemicals for direct cell-killing ability have been developed over the last 2 decades. These conjugated or fused chimeric proteins are termed immunotoxins or cytotoxic agents. Two agents, DAB389IL-2 (ONTAKTM) targeting the interleukin-2 receptor and CD33-c

Стилі APA, Harvard, Vancouver, ISO та ін.

7

Weldon, John E., Laiman Xiang, Oleg Chertov, et al. "A protease-resistant immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity." Blood 113, no. 16 (2009): 3792–800. http://dx.doi.org/10.1182/blood-2008-08-173195.

Повний текст джерела

Анотація:

Abstract Immunotoxins based on Pseudomonas exotoxin A (PE) are promising anticancer agents that combine a variable fragment (Fv) from an antibody to a tumor-associated antigen with a 38-kDa fragment of PE (PE38). The intoxication pathway of PE immunotoxins involves receptor-mediated internalization and trafficking through endosomes/lysosomes, during which the immunotoxin undergoes important proteolytic processing steps but must otherwise remain intact for eventual transport to the cytosol. We have investigated the proteolytic susceptibility of PE38 immunotoxins to lysosomal proteases and found

Стилі APA, Harvard, Vancouver, ISO та ін.

8

Narbona, Javier, Rubén G. Gordo, Jaime Tomé-Amat та Javier Lacadena. "A New Optimized Version of a Colorectal Cancer-Targeted Immunotoxin Based on a Non-Immunogenic Variant of the Ribotoxin α-Sarcin". Cancers 15, № 4 (2023): 1114. http://dx.doi.org/10.3390/cancers15041114.

Повний текст джерела

Анотація:

Due to its incidence and mortality, cancer remains one of the main risks to human health and lifespans. In order to overcome this worldwide disease, immunotherapy and the therapeutic use of immunotoxins have arisen as promising approaches. However, the immunogenicity of foreign proteins limits the dose of immunotoxins administered, thereby leading to a decrease in its therapeutic benefit. In this study, we designed two different variants of non-immunogenic immunotoxins (IMTXA33αSDI and IMTXA33furαSDI) based on a deimmunized variant of the ribotoxin α-sarcin. The inclusion of a furin cleavage s

Стилі APA, Harvard, Vancouver, ISO та ін.

9

Balalaeva, I. V., E. A. Sokolova, A. D. Puzhikhina, A. A. Brilkina, and S. M. Deyev. "Spheroids of HER2-Positive Breast Adenocarcinoma for Studying Anticancer Immunotoxins In Vitro." Acta Naturae 9, no. 1 (2017): 38–44. http://dx.doi.org/10.32607/20758251-2017-9-1-38-44.

Повний текст джерела

Анотація:

Tumor response to therapeutic treatment is largely determined by its heterogeneity and the presence of intercellular junctions, hindering the penetration of large molecules deep into the three-dimensional structure of the tumor. In that context, 3D in vitro tumor models such as cancer cell spheroids are becoming increasingly popular. We obtained spheroids of human breast adenocarcinoma SKBR-3 overexpressing the HER2 cancer marker. The toxicity of HER2-targeted immunotoxin 4D5scFv-PE40 against spheroids was shown to be several orders of magnitude lower compared to a monolayer cell culture. The

Стилі APA, Harvard, Vancouver, ISO та ін.

10

Ruiz-de-la-Herrán, Javier, Jaime Tomé-Amat, Rodrigo Lázaro-Gorines, José G. Gavilanes та Javier Lacadena. "Inclusion of a Furin Cleavage Site Enhances Antitumor Efficacy against Colorectal Cancer Cells of Ribotoxin α-Sarcin- or RNase T1-Based Immunotoxins". Toxins 11, № 10 (2019): 593. http://dx.doi.org/10.3390/toxins11100593.

Повний текст джерела

Анотація:

Immunotoxins are chimeric molecules that combine the specificity of an antibody to recognize and bind tumor antigens with the potency of the enzymatic activity of a toxin, thus, promoting the death of target cells. Among them, RNases-based immunotoxins have arisen as promising antitumor therapeutic agents. In this work, we describe the production and purification of two new immunoconjugates, based on RNase T1 and the fungal ribotoxin α-sarcin, with optimized properties for tumor treatment due to the inclusion of a furin cleavage site. Circular dichroism spectroscopy, ribonucleolytic activity s

Стилі APA, Harvard, Vancouver, ISO та ін.

Більше джерел

Ми пропонуємо знижки на всі преміум-плани для авторів, чиї праці увійшли до тематичних добірок літератури. Зв'яжіться з нами, щоб отримати унікальний промокод!