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Статті в журналах з теми "Therapeutic use of wine"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 20 лютого 2023

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1

Sirbu, Rodica, Ticuta Negreanu-Pirjol, and Bogdan Stefan Negreanu-Pirjol. "Important Properties of Grapes and Wine from the Dobrogea Area for Therapeutic Use." European Journal of Medicine and Natural Sciences 4, no. 2 (October 15, 2021): 59. http://dx.doi.org/10.26417/746ygx85s.

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Starting from Herodotus who states that: No cure can cure like wine and can not inspire like it. From antiquity until now grapes and wine represent a viable alternative in multiple therapies if we know how and when to consume these products. This paper is a study that comes to present concretely the beneficial impact of the products that the vine offers us, the plant cultivated in the location of our Dobrogean area. Grapes contain reducing sugars, malic acid, succinic acid, flavonic derivatives, lecithin, choline, leucine, wax and minerals. Wine also has special properties in cellular and ment

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2

Gallagher, Lisa M., and Francois Bethoux. "Therapeutic use of the Arts for Patients with Multiple Sclerosis." US Endocrinology 13, no. 02 (2017): 82. http://dx.doi.org/10.17925/use.2017.13.02.82.

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People with multiple sclerosis (MS) face a wide variety of physical, emotional, and social challenges. A multidisciplinary comprehensive care approach is recommended for the management of MS and its consequences, and non-traditional treatments are increasingly considered by patients and health care providers, particularly for the promotion of wellness in the context of this chronic disease. Previous research has demonstrated the benefits of the therapeutic arts (art therapy, dance and movement therapy, and music therapy) in addressing some of the physiological, psychological, cognitive, social

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3

Zhang, Songxia, Ying Xu, Mengling Ye, Wenli Ye, Jian Xiao, Honghao Zhou, Wei Zhang, Yan Shu, Yun Huang, and Yao Chen. "Resveratrol in Liquor Exacerbates Alcoholic Liver Injury with a Reduced Therapeutic Effect in Mice: An Unsupervised Herbal Wine Habit Is Risky." Nutrients 14, no. 22 (November 10, 2022): 4752. http://dx.doi.org/10.3390/nu14224752.

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People in Eastern countries hold a tradition of soaking herbal medicine in wine; however, the efficacy and safety of herbal wine have not been rigorously assessed. By assessing the efficacy of resveratrol (RSV) in ethanol against alcoholic liver disease (ALD) in mice, we aimed to offer a perspective on the use of herbal wine. To simulate the behaviour of herbal wine users, RSV (15 mg/kg) soaked in ethanol (RSV-alcohol) was administrated via gavage to the mice, here with alcohol consumption-induced ALD. RSV soaked in water (RSV-water) was the treatment control. The efficacy and safety of RSV on

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4

Piccolo, D., D. Di Marcantonio, G. Crisman, G. Cannarozzo, M. Sannino, A. Chiricozzi, and S. Chimenti. "Unconventional Use of Intense Pulsed Light." BioMed Research International 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/618206.

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According to the literature, intense pulsed light (IPL) represents a versatile tool in the treatment of some dermatological conditions (i.e., pigmentation disorders, hair removal, and acne), due to its wide range of wavelengths. The authors herein report on 58 unconventional but effective uses of IPL in several cutaneous diseases, such as rosacea (10 cases), port-wine stain (PWS) (10 cases), disseminated porokeratosis (10 cases), pilonidal cyst (3 cases), seborrheic keratosis (10 cases), hypertrophic scar (5 cases) and keloid scar (5 cases), Becker’s nevus (2 cases), hidradenitis suppurativa (

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5

Miao, Ming San, Lin Guo, Shan Cao, and Xiao Fang Guo. "The Research of Topical Analgesic Effect on Arisaema Wine Paste, Vinegar Paste." Applied Mechanics and Materials 664 (October 2014): 429–32. http://dx.doi.org/10.4028/www.scientific.net/amm.664.429.

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To study the analgesic effect of Arisaema wine paste, vinegar paste for external use. By two pain tests induced by formaldehyde and by hot plate ,observing the effect of high and low-dose of different varieties Arisaema with wine paste and vinegar paste on the the behavior of model mice.In the pain tests induced by formaldehyde,after administration of 5min and 10min,high and low-dose of different varieties Arisaema with wine paste and vinegar paste can significantly reduced the number of times of mice licking foot (P<0.01).In the pain tests induced by hot plate,after the administration of 3

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6

Gallagher, Lisa M., and Francois Bethoux. "Therapeutic use of the Arts for Patients with Multiple Sclerosis." US Neurology 13, no. 02 (2017): 82. http://dx.doi.org/10.17925/usn.2017.13.02.82.

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Анотація:

People with multiple sclerosis (MS) face a wide variety of physical, emotional, and social challenges. A multidisciplinary comprehensive care approach is recommended for the management of MS and its consequences, and non-traditional treatments are increasingly considered by patients and health care providers, particularly for the promotion of wellness in the context of this chronic disease. Previous research has demonstrated the benefits of the therapeutic arts (art therapy, dance and movement therapy, and music therapy) in addressing some of the physiological, psychological, cognitive, social

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7

Bohara, Raghvendra A., Nazish Tabassum, Mohan P. Singh, Giuseppe Gigli, Andrea Ragusa, and Stefano Leporatti. "Recent Overview of Resveratrol’s Beneficial Effects and Its Nano-Delivery Systems." Molecules 27, no. 16 (August 12, 2022): 5154. http://dx.doi.org/10.3390/molecules27165154.

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Natural polyphenols have a wide variety of biological activities and are taken into account as healthcare materials. Resveratrol is one such natural polyphenol, belonging to a group known as stilbenoids (STBs). Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is mainly found in grapes, wine, nuts, and berries. A wide range of biological activities has been demonstrated by resveratrol, including antimicrobial, antioxidant, antiviral, antifungal, and antiaging effects, and many more are still under research. However, as with many other plant-based polyphenol products, resveratrol suffers from low

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8

Gubergrits, N. B., N. V. Byelyayeva, A. Ye Klochkov, P. G. Fomenko, and G. M. Lukashevich. "Engilen: from different therapeutic possibilities to effective clinical use." Herald of Pancreatic Club 43, no. 2 (May 3, 2019): 70–81. http://dx.doi.org/10.33149/vkp.2019.02.10.

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Composition of the Engilen preparation, medicinal properties of plants that make up the preparation, indications for its prescription are analyzed in detail in the article. Particular attention is paid to the advantages of Engilen, such as: optimal doses and ratio of active ingredients, wide range of indications, effectiveness upon combined diseases of the digestive system and with the concomitant pathology of other organs and systems. The results of our own study are presented, showing the effectiveness of Engilen upon chronic acalculous cholecystitis and non-alcoholic steatohepatitis in pati

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9

Zhang, Ming-Qiang. "Chemistry Underlying the Cardiotoxicity of Antihistaminest." Current Medicinal Chemistry 4, no. 3 (June 1997): 171–84. http://dx.doi.org/10.2174/0929867304666220313110659.

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Antihistamines are very useful therapeutic agents for the treatment of allergic diseases, and are one of the most frequently prescribed medicines world-wide. Despite the excellent safety record of antihistamines, the recent reports on cardiac toxicity associated with the use of antihistamines have caused wide-spread concerns among both the scientific community and the general public. This review delineates the molecular factors underlying this potentially devastating side effect of the otherwise . very safe therapeutics, including their pharmacodynamic activities on car d1ac potass1um channels

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10

Tolstun, Denis, Khachik Muradian, and Vladislav Bezrukov. "Therapeutic hypercapnia. Review." Issue 3 2022, no. 3 2022 (August 28, 2022): 101–13. http://dx.doi.org/10.47855/al9020-2022-3-5.

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In recent years, interest in hypercapnia and its practical applications has grown significantly. An analysis of literature data shows a wide range of systemic and local applications. Due to its powerful effect on blood circulation, vascular elasticity, activation of angiogenesis, and inhibition of pro-inflammatory factors, hypercapnia is already used in dermatology, phlebology, and therapy. Wide opportunities open up for practical use in neurology, given the powerful neuroprotective effect of carbon dioxide, which not only increases tolerance to ischemia, preventing the development of diseases

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11

Balanov, Petr E., Irina V. Smotraeva, Malika S. Abdullaeva, Daria A. Volkova, and Olga B. Ivanchenko. "Study on resveratrol content in grapes and wine products." E3S Web of Conferences 247 (2021): 01063. http://dx.doi.org/10.1051/e3sconf/202124701063.

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The current state of the agro-industrial complex and the food industry allows to satisfy the needs of various consumers groups. Among those needs, functional foods enriched with beneficial nutrients are becoming more and more popular. Polyphenols are sometimes used as such additives. The bioflavonoid resveratrol, among the group of polyphenols, has very promising antioxidant, therapeutic, antimicrobial properties. In this regard, studying the potential of its use in the food is highly relevant. Resveratrol is naturally present in the dark grapes. It is localized in the skin of the fruit and pa

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12

Bukhari, Syed Nasir Abbas. "Dietary Polyphenols as Therapeutic Intervention for Alzheimer’s Disease: A Mechanistic Insight." Antioxidants 11, no. 3 (March 15, 2022): 554. http://dx.doi.org/10.3390/antiox11030554.

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Dietary polyphenols encompass a diverse range of secondary metabolites found in nature, such as fruits, vegetables, herbal teas, wine, and cocoa products, etc. Structurally, they are either derivatives or isomers of phenol acid, isoflavonoids and possess hidden health promoting characteristics, such as antioxidative, anti-aging, anti-cancerous and many more. The use of such polyphenols in combating the neuropathological war raging in this generation is currently a hotly debated topic. Lately, Alzheimer’s disease (AD) is emerging as the most common neuropathological disease, destroying the live

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13

Wang, Xingtao, Chunlai Tian, Xingguang Duan, Ying Gu, and Naiyan Huang. "A Medical Manipulator System with Lasers in Photodynamic Therapy of Port Wine Stains." BioMed Research International 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/384646.

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Port wine stains (PWS) are a congenital malformation and dilation of the superficial dermal capillary. Photodynamic therapy (PDT) with lasers is an effective treatment of PWS with good results. However, because the laser density is uneven and nonuniform, the treatment is carried out manually by a doctor thus providing little accuracy. Additionally, since the treatment of a single lesion can take between 30 and 60 minutes, the doctor can become fatigued after only a few applications. To assist the medical staff with this treatment method, a medical manipulator system (MMS) was built to operate

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14

Ito, Matthew K. "Statin Drug Interactions in Patients with Comorbidities and on Multiple Medications." US Endocrinology 08, no. 02 (2012): 104. http://dx.doi.org/10.17925/use.2012.08.02.104.

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Extensive clinical evidence has demonstrated the efficacy of statin treatment in the prevention of cardiovascular disease (CVD). However, nearly half of patients taking statins discontinue their use, largely as a result of side effects. Many patients receiving statins are elderly, and/or have comorbid conditions, increasing the potential for drug-drug interactions (DDIs). Statin DDIs are largely the result of altered drug metabolism via cytochrome P450s (CYPs), glucuronidation or altered drug transport via organic anion-transporting polypeptides (OATPs) and P-glycoprotein (P-gp). There is a ne

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15

Baysan, Aylin, and Edward Lynch. "The Use of Ozone in Dentistry and Medicine." Primary Dental Care os12, no. 2 (April 2005): 47–52. http://dx.doi.org/10.1308/1355761053695158.

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There is growing interest in the use of ozone in oral healthcare and the National Institute for Clinical Excellence (NICE) is at present reviewing the evidence for its effectiveness in the management of occlusal and plain surface caries. These are only two of the clinical problems for which ozone can, and has, been used; it has also been employed for a wide variety of other purposes in both dentistry and medicine. This pale blue-coloured gas plays an important role as a natural constituent in the higher layer of the Earth's atmosphere. There is growing evidence that it can be employed as a use

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16

Roshani P Gandhi, Gautam D Mehetre, Shital J Gandhi, and Shivani P Wadichar. "A systematic review of therapeutic proteins as a promising approach to treat various diseases." GSC Biological and Pharmaceutical Sciences 22, no. 1 (January 30, 2023): 157–69. http://dx.doi.org/10.30574/gscbps.2023.22.1.0016.

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Proteins if said as ‘magic molecules’ will not prove false because of a varied play it can deal with in view of health sector. In the past couple of decades, therapeutic proteins have gained significance as therapy for a wide range of diseases like cancer, cardiovascular, diabetes and some other diseases. Moreover, recently USFDA protein therapeutic products are also playing an important role in this concern. Whereas therapeutic application of whey protein is rapidly on its way to be proved helpful. The thing of concern to use of these therapeutic proteins for the treatment of various diseases

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17

Shilin, D. Ye, I. I. Dedov, and Ye A. Grigoryeva. "Spironolactone therapeutic effect in the hyperandrogenism syndrome." Problems of Endocrinology 39, no. 2 (April 15, 1993): 55–60. http://dx.doi.org/10.14341/probl11979.

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Hyperandrogenism syndrome, the main manifestations of which are pathological hirsutism, acne, oily seborrhea, androgenic alopecia, accompanies a wide range of diseases of the female reproductive system, manifested by various disorders of menstrual function and infertility. Isolated hirsutism is also a serious psychological and cosmetic problem, especially since almost one in ten women of reproductive age have excessive hair growth. To get rid of "excess" hair, women use various methods. However, in severe manifestations of hyperandrogenism or in the case of severe and moderate hirsutism, it is

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18

Rzeźnicka, Zofia, and Maciej Kokoszko. "Wine and Myrrh as Medicaments or a Commentary on Some Aspects of Ancient and Byzantine Mediterranean Society." Studia Ceranea 9 (December 30, 2019): 615–55. http://dx.doi.org/10.18778/2084-140x.09.31.

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The present study has resulted from a close reading of prescriptions for therapeutic wines inserted in book V of De materia medica by Pedanius Dioscorides, the eminent expert in materia medica of the 1st century A.D. The authors emphasise the role of wine varieties and selected flavourings (and especially of myrrh) in order to determine the social status of those to whom the formulas were addressed. This perspective gives the researchers ample opportunity for elaborating not only on the significance of wine in medical procedures but also for underscoring the importance of a number of aromatics

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19

Connolly, A. "Replacing Sub - Therapeutic Antibiotics in Feed with Consumer Acceptable Performance Enhancers." Open Access Journal of Veterinary Science & Research 2, no. 1 (2017): 1–13. http://dx.doi.org/10.23880/oajvsr-16000122.

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Since introduction in the late 1940s, the role of antibiotics in animal production has changed. Originally a means of combating illnesses and maintaining the health of flocks and herds, it was soon recognized that antibiotics could drastically increase productivity and financial return through enhanced and expedited weight gain. Since then criticism has been leveled at the use of antibiotics at sub - therapeutic levels to promote growth and feed conversion efficiency. Although the recent demonstration that plasmid genes encoding for resistance are present in the environ ment and feces of swine

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20

Hedner, Ulla. "Factor VIIa and its potential therapeutic use in bleeding-associated pathologies." Thrombosis and Haemostasis 100, no. 10 (2008): 557–62. http://dx.doi.org/10.1160/th08-07-0434.

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SummaryRecombinant FVIIa (rFVIIa) was developed for treatment of haemophilia patients with inhibitors against FVIII/FIX. The haemostatic efficacy rate of 80–90% including major orthopaedic surgery (dosing of 90–120 µg/kg every other hour [h] for at least the first 24 h) was achieved in these patients. In a home-treatment setting the efficacy rate of haemostasis in mild-moderate bleedings was 92% (average number of 90 µg/kg doses was 2.2). A wide individual variation regarding recovery of rFVIIa (46 ± 12%; median 43%) as well as of clearance rate (36 ± 8 ml/kg/h; median 32 ml/kg/h in adults;chi

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21

Díaz-García, Diana, Sanjiv Prashar, and Santiago Gómez-Ruiz. "Biological Use of Nanostructured Silica-Based Materials Functionalized with Metallodrugs: The Spanish Perspective." International Journal of Molecular Sciences 24, no. 3 (January 25, 2023): 2332. http://dx.doi.org/10.3390/ijms24032332.

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Since the pioneering work of Vallet-Regí’s group on the design and synthesis of mesoporous silica-based materials with therapeutic applications, during the last 15 years, the potential use of mesoporous silica nanostructured materials as drug delivery vehicles has been extensively explored. The versatility of these materials allows the design of a wide variety of platforms that can incorporate numerous agents of interest (fluorophores, proteins, drugs, etc.) in a single scaffold. However, the use of these systems loaded with metallodrugs as cytotoxic agents against different diseases and with

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22

BJ, Pereira. "Therapeutic Approach to Erectile Dysfunction - News and Future Perspectives." Open Access Journal of Urology & Nephrology 7, no. 1 (January 7, 2022): 1–8. http://dx.doi.org/10.23880/oajun-16000201.

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Erectile dysfunction is defined as the inability to get or keep an erection that is sufficient for satisfactory sexual intercourse. It is one of the most prevalent sexual dysfunctions in men, usually correlated with aging. This pathology is generally associated with repercussions in the psychological and social well-being of the patient and his relationship with his partner. This way, it is considered an important cause of a decrease in quality of life. The treatments available today, in most cases, solve the symptoms, however, none of them can reverse the physiopathological basis of erectile

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23

Fielding, Burtram C., Carlos da Silva Maia Bezerra Filho, Nasser S. M. Ismail, and Damião Pergentino de Sousa. "Alkaloids: Therapeutic Potential against Human Coronaviruses." Molecules 25, no. 23 (November 24, 2020): 5496. http://dx.doi.org/10.3390/molecules25235496.

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Alkaloids are a class of natural products known to have wide pharmacological activity and have great potential for the development of new drugs to treat a wide array of pathologies. Some alkaloids have antiviral activity and/or have been used as prototypes in the development of synthetic antiviral drugs. In this study, eleven anti-coronavirus alkaloids were identified from the scientific literature and their potential therapeutic value against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is discussed. In this study, in silico studies showed an affinity of the alkaloids for bind

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24

Bajan, Sarah, and Gyorgy Hutvagner. "RNA-Based Therapeutics: From Antisense Oligonucleotides to miRNAs." Cells 9, no. 1 (January 7, 2020): 137. http://dx.doi.org/10.3390/cells9010137.

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The first therapeutic nucleic acid, a DNA oligonucleotide, was approved for clinical use in 1998. Twenty years later, in 2018, the first therapeutic RNA-based oligonucleotide was United States Food and Drug Administration (FDA) approved. This promises to be a rapidly expanding market, as many emerging biopharmaceutical companies are developing RNA interference (RNAi)-based, and RNA-based antisense oligonucleotide therapies. However, miRNA therapeutics are noticeably absent. miRNAs are regulatory RNAs that regulate gene expression. In disease states, the expression of many miRNAs is measurably

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25

Varani, Michela, Valeria Bentivoglio, Chiara Lauri, Danilo Ranieri, and Alberto Signore. "Methods for Radiolabelling Nanoparticles: SPECT Use (Part 1)." Biomolecules 12, no. 10 (October 20, 2022): 1522. http://dx.doi.org/10.3390/biom12101522.

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The use of nanoparticles (NPs) is rapidly increasing in nuclear medicine for diagnostic and therapeutic purposes. Their wide use is due to their chemical–physical characteristics and possibility to deliver several molecules. NPs can be synthetised by organic and/or inorganic materials and they can have different size, shape, chemical composition, and char. These factors influence their biodistribution, clearance, and targeting ability in vivo. NPs can be designed to encapsulate inside the core or bind to the surface on several molecules, including radionuclides, for different clinical applicat

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26

Pichini, Simona, Alfredo Fabrizio Lo Faro, Francesco Paolo Busardò, and Raffaele Giorgetti. "Medicinal Cannabis and Synthetic Cannabinoid Use." Medicina 56, no. 9 (September 7, 2020): 453. http://dx.doi.org/10.3390/medicina56090453.

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Cannabis products have been used for centuries by humans for recreational and medical purposes. Resent research, proposed the promising therapeutic potential of cannabis and related cannabinoids for a wide range of medical conditions, including psychiatric and neurological diseases. This Special Issue presents the latest updates on medicinal cannabis and synthetic cannabinoids pharmacology, toxicology and new analytical methods to identify and quantify these compounds in conventional and non-conventional biological matrices. Moreover, it provides current data regarding their adverse effects, s

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27

Balazs, Daniel A., and WT Godbey. "Liposomes for Use in Gene Delivery." Journal of Drug Delivery 2011 (December 15, 2011): 1–12. http://dx.doi.org/10.1155/2011/326497.

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Liposomes have a wide array of uses that have been continuously expanded and improved upon since first being observed to self-assemble into vesicular structures. These arrangements can be found in many shapes and sizes depending on lipid composition. Liposomes are often used to deliver a molecular cargo such as DNA for therapeutic benefit. The lipids used to form such lipoplexes can be cationic, anionic, neutral, or a mixture thereof. Herein physical packing parameters and specific lipids used for gene delivery will be discussed, with lipids classified according to overall charge.

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28

Gándara, Zoila, Noelia Rubio, and Rafael R. Castillo. "Delivery of Therapeutic Biopolymers Employing Silica-Based Nanosystems." Pharmaceutics 15, no. 2 (January 20, 2023): 351. http://dx.doi.org/10.3390/pharmaceutics15020351.

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The use of nanoparticles is crucial for the development of a new generation of nanodevices for clinical applications. Silica-based nanoparticles can be tailored with a wide range of functional biopolymers with unique physicochemical properties thus providing several advantages: (1) limitation of interparticle interaction, (2) preservation of cargo and particle integrity, (3) reduction of immune response, (4) additional therapeutic effects and (5) cell targeting. Therefore, the engineering of advanced functional coatings is of utmost importance to enhance the biocompatibility of existing biomat

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29

Reva, Yana. "AESTHETIC AND THERAPEUTIC POTENTIAL CHOREOGRAPHY." Aesthetics and Ethics of Pedagogical Action, no. 14 (September 9, 2016): 184–91. http://dx.doi.org/10.33989/2226-4051.2016.14.171614.

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The article is about necessity of psyco-pedagogical attention to the problems of people psycophysical and emotional health saving. In order to get this difficult goal real, art of dance helps person to understand himself and leads to selfperfection. The dance is a merge of physical, psychological and esthetic activities. But the art of dance is also a therapeutic factor and its value is rising with developing of sangennic role of the art in modern life and in harmonization of Human-Universe relations.Functionality of dance art is quite wide. Thoughtful usage of dance impact leads to psychologi

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30

Wadhwa, A., A. Sareen, and Y. Saade. "TMS use in Depressive disorder in Youth." European Psychiatry 65, S1 (June 2022): S739. http://dx.doi.org/10.1192/j.eurpsy.2022.1908.

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Introduction Trans-cranial magnetic stimulation (TMS) as a non-invasive method of altering brain activity (1) has widened the array of therapeutic options available for various psychiatric disorders. Objectives Trans-cranial Magnetic stimulation (TMS) as a non-invasive method of altering brain activity has widened the array of therapeutic options available for various psychiatric disorders. •A large number of studies have shown therapeutic benefits in a wide range of patient population with majority of studies in adults. •TMS is used increasingly for the treatment of child and adolescent depre

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31

Rusconi, Christopher, Bruce Sullenger, and Richard Becker. "Nucleic acid aptamers in therapeutic anticoagulation." Thrombosis and Haemostasis 93, no. 06 (2005): 1014–20. http://dx.doi.org/10.1160/th04-12-0790.

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SummaryThe evolution of anticoagulant therapy for the prevention and treatment of thrombotic disorders has progressed at a relatively modest pace considering the scope of the problem and our current understanding of platelet biology, coagulation proteases, and vascular science as they apply to protective haemostasis and pathologic thrombosis. Recent observations, dedicated to cellular-based models of coagulation, provide fundamental constructs, mechanistic clarity, and potentially unparalleled opportunity for accelerating the development and wide-scale clinical use of safe, effective, regulata

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32

Valko, Peter C., Jack P. Campbell, David L. McCarty, Dennis Martin, and Joe Turnbull. "Prehospital Use of Pulse Oximetry in Rotary-Wing Aircraft." Prehospital and Disaster Medicine 6, no. 4 (December 1991): 421–28. http://dx.doi.org/10.1017/s1049023x00038905.

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AbstractA prospective study of 200 patients was conducted to evaluate the use of pulse oximetry as an adjunct to clinical monitoring of critically ill patients transported by rotary-wing aircraft with non-pressurized cabins. Thirty-four subjects (17%) were found to have significant hemoglobin desaturation of less than 90%, as defined by pulse oximetry (SpO2). Data were recorded continuously for later review. Desaturation often was noted prior to alterations in vital signs or clinical appearance. In 32 of the 34 hypoxemic subjects (94%), therapeutic interventions corrected the low SpO2. The use

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Lavorini, Federico. "The Challenge of Delivering Therapeutic Aerosols to Asthma Patients." ISRN Allergy 2013 (August 5, 2013): 1–17. http://dx.doi.org/10.1155/2013/102418.

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The number of people with asthma continues to grow around the world, and asthma remains a poorly controlled disease despite the availability of management guidelines and highly effective medication. Patient noncompliance with therapy is a major reason for poor asthma control. Patients fail to comply with their asthma regimen for a wide variety of reasons, but incorrect use of inhaler devices is amongst the most common. The pressurised metered-dose inhaler (pMDI) is still the most frequently used device worldwide, but many patients fail to use it correctly, even after repeated tuition. Breath-a

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34

Washburn, Nathaniel, Inessa Schwab, Daniel Ortiz, Naveen Bhatnagar, Jonathan C. Lansing, Amy Medeiros, Steven Tyler, et al. "Controlled tetra-Fc sialylation of IVIg results in a drug candidate with consistent enhanced anti-inflammatory activity." Proceedings of the National Academy of Sciences 112, no. 11 (March 2, 2015): E1297—E1306. http://dx.doi.org/10.1073/pnas.1422481112.

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Despite the beneficial therapeutic effects of intravenous immunoglobulin (IVIg) in inflammatory diseases, consistent therapeutic efficacy and potency remain major limitations for patients and physicians using IVIg. These limitations have stimulated a desire to generate therapeutic alternatives that could leverage the broad mechanisms of action of IVIg while improving therapeutic consistency and potency. The identification of the important anti-inflammatory role of fragment crystallizable domain (Fc) sialylation has presented an opportunity to develop more potent Ig therapies. However, translat

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35

Vidal, Enrico, Francesco Garzotto, Mattia Parolin, Chiara Manenti, Anna Zanin, Massimo Bellettato, Giuseppe Remuzzi, Stuart L. Goldstein, Luisa Murer, and Claudio Ronco. "Therapeutic Plasma Exchange in Neonates and Infants: Successful Use of a Miniaturized Machine." Blood Purification 44, no. 2 (2017): 100–105. http://dx.doi.org/10.1159/000470827.

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Therapeutic plasma exchange (TPE) in neonates and small infants is a treatment method at the forefront that may become a potentially life-saving procedure in a wide array of severe conditions. Indications for TPE in the pediatric population have been mainly derived from adult literature, with neonatal hyperbilirubinemia being the most notable exception. The only alternative to TPE in small pediatric patients is manual blood exchange transfusion, which, however, bears an unacceptably high risk of severe complications. Still, technical issues due to extracorporeal circulation in neonates have bu

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Marson, Justin, and Mark Lebwohl. "Apremilast as an Off-Label Therapeutic Agent." SKIN The Journal of Cutaneous Medicine 5, no. 3 (May 17, 2021): 203–27. http://dx.doi.org/10.25251/skin.5.3.2.

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Objective: To review the literature regarding the efficacy and safety of off-label use of apremilast in combination therapies for psoriasis and psoriatic arthritis and for other currently off-label inflammatory dermatoses. Methods: The Medline database was queried for all relevant articles published between 2014 and 2021 using exploded MeSH terms and keywords pertaining to the following themes: off-label, combination therapy, biologics, biologic therapy, methotrexate, and systemic psoriasis therapy. The Boolean term “AND” was used to find the intersection of these themes with the term “apremil

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Lewis, Jamal S., and Riley P. Allen. "An introduction to biomaterial-based strategies for curbing autoimmunity." Experimental Biology and Medicine 241, no. 10 (May 2016): 1107–15. http://dx.doi.org/10.1177/1535370216650294.

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Recently, scientists have made significant progress in the development of immunotherapeutics that correct aberrant, autoimmune responses. Yet, concerns about the safety, efficacy, and wide scale applicability continue to hinder use of contemporary, immunology-based strategies. There is a clear need for therapies that finely control molecular and cellular elements of the immune system. Biomaterial engineers have taken up this challenge to develop therapeutics with selective spatial and temporal control of immune cells. In this review, we introduce the immunology of autoimmune disorders, survey

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Adamski, Jill. "Thrombotic microangiopathy and indications for therapeutic plasma exchange." Hematology 2014, no. 1 (December 5, 2014): 444–49. http://dx.doi.org/10.1182/asheducation-2014.1.444.

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Abstract Thrombotic microangiopathy (TMA) is a clinicopathological condition associated with a wide variety of medical conditions. TMA is classically characterized by microangiopathic hemolytic anemia, thrombocytopenia, and microvascular thrombi that cause end-organ damage. The most prominent diagnoses associated with TMA are thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS). Although TTP and HUS can have similar clinical and laboratory features and are often lumped together as a combined entity referred to as “TTP/HUS,” the pathologic processes causing TMA and opti

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Chen, Youdong, Qian Yu, Yifan Hu, and Yuling Shi. "Current Research and Use of Mesenchymal Stem Cells in the Therapy of Autoimmune Diseases." Current Stem Cell Research & Therapy 14, no. 7 (September 23, 2019): 579–82. http://dx.doi.org/10.2174/1574888x14666190429141421.

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: Mesenchymal Stem Cells (MSCs) represent a heterogeneous group of self-renewal, multipotent non-hematopoietic stem cells, which display profound immunomodulatory functions and promising therapeutic effects. Autoimmune diseases, which result from an aberrant immune response to selfantigens, can be detrimental to nearly all body tissues. With the advance in developing a novel treatment, including biological agents, it is still impossible to cure autoimmune disorders. Recent studies demonstrate the remarkable therapeutic effectiveness of MSCs towards a wide array of autoimmune diseases. In this

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40

Shahriar, S., Jagannath Mondal, Mohammad Hasan, Vishnu Revuri, Dong Lee, and Yong-Kyu Lee. "Electrospinning Nanofibers for Therapeutics Delivery." Nanomaterials 9, no. 4 (April 3, 2019): 532. http://dx.doi.org/10.3390/nano9040532.

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The limitations of conventional therapeutic drugs necessitate the importance of developing novel therapeutics to treat diverse diseases. Conventional drugs have poor blood circulation time and are not stable or compatible with the biological system. Nanomaterials, with their exceptional structural properties, have gained significance as promising materials for the development of novel therapeutics. Nanofibers with unique physiochemical and biological properties have gained significant attention in the field of health care and biomedical research. The choice of a wide variety of materials for n

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Karki, Karuna T., Pramod K. Chaudhary, Binod Bhattarai, and Sunil Munakomi. "Complex Cerebrovascular Presentation in Central Nepal with Therapeutic Challenge." Nepal Journal of Neuroscience 12, no. 2 (October 8, 2016): 73–80. http://dx.doi.org/10.3126/njn.v12i2.15898.

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Effective management of complex vascular malformation remains one of the more challenging problems faced in most of the developing countries where modern therapeutic resources are deficient. Giant arteriovenous malformations and other vascular malformation like dural arteriovenous malformations are often associated with higher morbidity and mortality rates. These lesions are considered as untreatable or inoperable. Endovascular therapy is an expanding science for managing complex vascular malformations in Nepal that has many constraints. This outset will have positive impact in the country tha

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Tsibulkina, V. N. "Leading mechanisms of the therapeutic effect of dimephosphone." Kazan medical journal 80, no. 2 (March 25, 1999): 120–22. http://dx.doi.org/10.17816/kazmj66460.

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A wide range of clinical efficiency of dimephosphone a home-made low-toxic organic phosphonis drug supposes its effect on the processes universal for most cellular systems. The basis of the leading mechanisms of effect of the drug is antagonism to calcium-dependent processes of the intracellular transfer of excitation. The concept of the therapeutic effect of dimephosphone on the basis of antiinflammatory, antihistaminic and antiagrega-tional properties with the recommendation to comprehensive use according to new indications in patients with chronic urticaria and acute erosive and ulcerous pr

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Walsh, David A., and Joanne Stocks. "New Therapeutic Targets for Osteoarthritis Pain." SLAS DISCOVERY: Advancing the Science of Drug Discovery 22, no. 8 (July 6, 2017): 931–49. http://dx.doi.org/10.1177/2472555217716912.

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Osteoarthritis (OA), the most common form of arthritis, causes pain and disability, as well as emotional distress. While total joint replacement is one of the most effective treatments available for improving the quality of life in people with severe OA, it is not suitable for all patients and all joints. Current pharmacological analgesics have limited efficacy, and their use is often restricted by adverse events. Medications that might reduce pain by slowing or preventing structural disease remain elusive. Our increasing understanding of the complex mechanisms that underlie OA pain offers a w

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44

Giovati, Laura, Tecla Ciociola, Tiziano De Simone, Stefania Conti, and Walter Magliani. "Wickerhamomyces Yeast Killer Toxins’ Medical Applications." Toxins 13, no. 9 (September 15, 2021): 655. http://dx.doi.org/10.3390/toxins13090655.

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Possible implications and applications of the yeast killer phenomenon in the fight against infectious diseases are reviewed, with particular reference to some wide-spectrum killer toxins (KTs) produced by Wickerhamomyces anomalus and other related species. A perspective on the applications of these KTs in the medical field is provided considering (1) a direct use of killer strains, in particular in the symbiotic control of arthropod-borne diseases; (2) a direct use of KTs as experimental therapeutic agents; (3) the production, through the idiotypic network, of immunological derivatives of KTs

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45

Khalid, Husna, Muneeba Rafique, Aimen Qaiser, Fakhar-Ud-Din, and Gul Shahnaz. "Carbon Nanotubes: A Brief Review on Its Use for Biomedical Imaging Purpose." Global Drug Design & Development Review IV, no. I (December 30, 2019): 24–33. http://dx.doi.org/10.31703/gdddr.2019(iv-i).03.

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Carbon nanotubes (CNTs) belong to the fullerene family, also known as graphene. These graphenes are similar to the graphite sheets and when these are turn up in the cylindrical form they are known as carbon nanotubes. Currently, the most common methods used for CNTs preparation are: Electric-arc-discharge methods, Chemical-vapor-deposition method and Laserablation method. In order to cross the cell membrane, functionalization of the pristine CNTs is performed. Because of the sp2 hybridization and closely packed hexagons in their structure, functionalization of the pristine CNTs can be done eas

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Capasso, Raffaele, and Lorenzo Di Cesare Mannelli. "Special Issue “Plant Extracts: Biological and Pharmacological Activity”." Molecules 25, no. 21 (November 4, 2020): 5131. http://dx.doi.org/10.3390/molecules25215131.

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47

Georgianos, Panagiotis I., Vasilios Vaios, Theodoros Eleftheriadis, Evangelos Papachristou, and Vassilios Liakopoulos. "Therapeutic Advances in Diabetic Kidney Disease." International Journal of Molecular Sciences 24, no. 3 (February 1, 2023): 2803. http://dx.doi.org/10.3390/ijms24032803.

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Although sodium glucose co-transporter type 2 (SGLT-2) inhibitors were initially introduced as glucose-lowering medications, it was later discovered that cardiorenal protection is the most important treatment effect of these agents. A triad of landmark trials consistently showed the benefits of SGLT-2 inhibitors on kidney and cardiovascular outcomes in patients with chronic kidney disease (CKD), irrespective of the presence or absence of Type 2 diabetes (T2D). Furthermore, finerenone is a novel, selective, nonsteroidal mineralocorticoid receptor antagonist (MRA) that safely and effectively imp

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Bounid, Oumayma, Tariq Igarramen, Youness El-Khadir, Rokkaya Iharti, Ghita Hadraoui, Sanae Chaouia, Mouna Darfaoui, Abdelhamid El Omrani, and Mouna Khouchani. "Therapeutic Management of Hidradenocarcinoma: Case Report and Literature Review." Scholars Journal of Medical Case Reports 9, no. 8 (August 5, 2021): 757–59. http://dx.doi.org/10.36347/sjmcr.2021.v09i08.003.

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Hidradenocarcinoma is a rare and aggressive carcinoma arising from sweat glands that manifests as an asymptomatic, slow-growing skin tumor. It metastasizes to regional lymph nodes and distant viscera. We report a case of 77 years old man who presented with an invasive hidradenocarcinoma of the scalp without lymph node involvement, treated by wide local excision and Post-operative radiotherapy. The management of this rare entity is not yet well defined. The results are still poor despite the use of multiple treatment modalities.

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Loebinger, Michael R., Susana Aguilar, and Sam M. Janes. "Therapeutic potential of stem cells in lung disease: progress and pitfalls." Clinical Science 114, no. 2 (December 11, 2007): 99–108. http://dx.doi.org/10.1042/cs20070073.

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There has been increasing excitement over the last few years with the suggestion that exogenous stem cells may offer new treatment options for a wide range of diseases. Within respiratory medicine, these cells have been shown to have the ability to differentiate and function as both airway and lung parenchyma epithelial cells in both in vitro and increasingly in vivo experiments. The hypothesis is that these cells may actively seek out damaged tissue to assist in the local repair, and the hope is that their use will open up new cellular and genetic treatment modalities. Such is the promise of

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Stefania, Silvia, Ripalta Colia, Rotondo Cinzia, Addolorata Corrado, and Francesco Paolo Cantatore. "Off-label use of anti-IL-1 drugs in rheumatic diseases." International Journal of Immunopathology and Pharmacology 35 (January 2021): 205873842110065. http://dx.doi.org/10.1177/20587384211006584.

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Interleukin-1 (IL-1) plays a key role in the pathogenesis of different rheumatic diseases. There are now several agents available on the market capable of blocking IL-1. The proven effectiveness and excellent safety of these drugs makes them a possible therapeutic option in the treatment of IL-1 driven diseases, when previous therapies are contraindicated or ineffective. This article discusses the European wide off-label use of these drugs for the treatment of rheumatic diseases.

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