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Дисертації з теми "Toll-like receptors"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 25 липня 2025

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1

Carrenho, Luciana Cristina de Andrade [UNESP]. "Avaliação ex vivo da expressão de TLR-2 e TLR-4 em leucócitos de equinos e sua relação com a tolerância à endotoxina." Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/92210.

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Made available in DSpace on 2014-06-11T19:25:37Z (GMT). No. of bitstreams: 0 Previous issue date: 2009-07-28Bitstream added on 2014-06-13T18:53:48Z : No. of bitstreams: 1 carrenho_lca_me_araca.pdf: 1197310 bytes, checksum: 3d5470911a8b6fe2c7996a8ec61a673a (MD5)<br>A endotoxemia é um importante distúrbio sistêmico que se origina da resposta do hospedeiro a um componente das bactérias Gram-negativas, o lipopolissacarídeo (LPS) ou endotoxina, que é liberado após bacteriólise ou rápida multiplicação. A ativação do sistema imune inato pelo LPS é um fator chave para o disparo da resposta inflamató

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2

Offord, Victoria Anne. "Toll-like receptors : from sequence to structure." Thesis, Royal Veterinary College (University of London), 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.669195.

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3

Irvine, Katherine Lucy. "The pharmacology of equine toll-like receptors." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608103.

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4

Dessing, Mark Christianus. "Toll-like receptors and innate immunity in pneumonia." [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2007. http://dare.uva.nl/document/47971.

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5

Philbin, Victoria Jane. "Identification & characterisation of avian toll-like receptors." Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425894.

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6

Cant, Rachel. "Modulation of toll like receptors by naltrexone hydrochloride." Thesis, St George's, University of London, 2017. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.753993.

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Naltrexone is an opioid antagonist usually used in the treatment of patients addicted to drugs or alcohol. However, since the 1980s naltrexone has been used at lower doses to treat patients with cancer and autoimmune diseases such as multiple sclerosis and Crohn’s disease. The mechanism of action of naltrexone in treating these diseases is unknown, however, evidence suggests that the drug has immune modulating effects. Toll like receptors (TLR) are type I membrane receptors that are crucial in the innate immune response. TLR recognise exogenous and endogenous ligands to induce the production o

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7

Kassem, Ali. "Toll-like receptors (TLRs) and inflammatory bone modeling." Doctoral thesis, Umeå universitet, Institutionen för odontologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-110296.

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Patients with inflammatory or infectious conditions such as periodontitis, peri-implantitis, osteomyelitis, rheumatoid arthritis, septic arthritis and loosened joint prosthesis display varying severity of destruction in the adjacent bone tissue. Bone loss in inflammatory diseases is considered a consequence of cytokine induced RANKL and subsequent enhanced osteoclast formation. Hence, osteotropic cytokines and their receptors have been suggested to be important for the pathogenesis of inflammation-induced osteolysis. It is, here, suggested that bacterial components, so called “pathogen associa

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8

Weber, Alexander Norman Rainer. "Structural and functional studies of Drosophila toll and human toll-like receptors." Thesis, University of Cambridge, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.615987.

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9

Braedel-Ruoff, Sibylla. "Toll-like receptors - link between innate and adaptive immunity." [S.l. : s.n.], 2007.

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10

Estévez, Medina Javier. "Toll-like receptors as modulators of intestinal barrier function." Doctoral thesis, Universitat Autònoma de Barcelona, 2016. http://hdl.handle.net/10803/400146.

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Las patologías funcionales (síndrome del intestino irritable, IBS) e inflamatorias gastrointestinales (enfermedad inflamatoria intestinal, IBD) se caracterizan por alteraciones de la función barrera epitelial, con un aumento de la permeabilidad, y cambios en la microbiota intestinal. Los receptores de tipo Toll (TLRs) participan en el reconocimiento bacteriano en el intestino y en el control neuroinmune local, estando, por tanto, implicados en la regulación de la función barrera del epitelio intestinal. El objetivo de este trabajo ha sido caracterizar la implicación de los receptores TLR5 y

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11

Wang, Jixin. "Bioinformatic analysis of chicken chemokines, chemokine receptors, and Toll-like receptor 21." Texas A&M University, 2006. http://hdl.handle.net/1969.1/4212.

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Chemokines triggered by Toll-like receptors (TLRs) are small chemoattractant proteins, which mainly regulate leukocyte trafficking in inflammatory reactions via interaction with G protein-coupled receptors. Forty-two chemokines and 19 cognate receptors have been found in the human genome. Prior to this study, only 11 chicken chemokines and 7 receptors had been reported. The objectives of this study were to identify systematically chicken chemokines and their cognate receptor genes in the chicken genome and to annotate these genes and ligand-receptor binding by a comparative genomics approach.

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12

Patole, Prashant. "Nucleic acid specific Toll-like receptors in lupus nephritis." Diss., lmu, 2006. http://nbn-resolving.de/urn:nbn:de:bvb:19-52560.

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13

Gong, Jing. "Databases and computational interaction models of Toll-like receptors." Diss., lmu, 2010. http://nbn-resolving.de/urn:nbn:de:bvb:19-115612.

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14

Lalanne, Ana. "Regulation of murine β lymphopoiesis by Toll like receptors". Paris 7, 2008. http://www.theses.fr/2008PA077220.

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Les récepteurs Toll like sont connus pour protéger de l'invasion des pathogènes et pour renforcer les réponses immunitaires. Notre objectif était d'étudier si le signal des TLRs est capable de réguler la lymphopoïèse B chez la souris. Nos résultats ont montré que les ligands de TLR2, TLR7 et TLR9 inhibent l'expansion in vitro des cellules pro-B. Nous avons étudié plus spécifiquement le TLR9, récepteur à l'ADN non méthylé contenant des motifs CpG. Le CpG inhibe l'expansion des cellules pro-B, mais n'a aucun effet sur les cellules pré-B. Le CpG inhibe l'expansion des cellules pro-B non pas par d

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15

Aboussahoud, Wedad. "The role of toll-like receptors in assisted conception." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/the-role-of-tolllike-receptors-in-assisted-conception(230bd2c9-e8bb-490f-b63f-9376667da89c).html.

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Background: In the last two decades the discovery of the Toll-Like Receptor (TLR) family in humans revealed the importance of innate immunity in providing host defence against invading pathogens. Moreover, TLRs have a vital role in mediating the interactions between the reproductive and immune systems. Similar to TLRs, (NOD)-like receptors (NLRs); retinoic acid-inducible gene-1, RIG-1-like receptors (RLRs) are also important pattern recognition receptors in the female reproductive system. Successful implantation requires effective reciprocal interactions between receptive endometrium and compe

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16

Milanski, Marciane 1972. "Efeitos de acidos graxos na indução de inflamação hipotalamica." [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310360.

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Orientador: Licio Augusto Velloso<br>Tese (doutorado) - Universidade Estadual de Campinas, FAculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-13T01:44:00Z (GMT). No. of bitstreams: 1 Milanski_Marciane_D.pdf: 2914055 bytes, checksum: 1a193ceb5c3d57d45f216d921184dc50 (MD5) Previous issue date: 2009<br>Resumo: O consumo de dietas ricas em gordura é o mais importante fator ambiental que contribui para o aumento da prevalência de obesidade na sociedade moderna. Em modelos animais com obesidade, induzida por dieta, a ativação da resposta inflamatória no hipotálamo produz resistên

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17

Longhini, Ana Leda Figueiredo 1978. "Participação das células dendríticas plasmocitóides na esclerose múltipla e na encefalomielite autoimune experimental = Role of plasmacytoid dendritic cells in multiple sclerosis and in experimental autoimmune encephalomyelitis." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310326.

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Orientador: Leonilda Maria Barbosa dos Santos<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-21T01:42:10Z (GMT). No. of bitstreams: 1 Longhini_AnaLedaFigueiredo_D.pdf: 9031331 bytes, checksum: 8341cfb783e3d43620c305cd18937b1e (MD5) Previous issue date: 2012<br>Resumo: No presente estudo demonstramos a ativação de mecanismos imunosupressores em células dendríticas plasmocitóides (pDCs) e linfócitos B pela ação do agonista de TLR-9, ODN-CpG no modelo de estudo da esclerose múltipla (EM) e na encefalomielite experime

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18

Jorgenson, Rebecca L. "The innate immune response and toll-like receptors in the human endometrium." Diss., Columbia, Mo. : University of Missouri-Columbia, 2005. http://hdl.handle.net/10355/4178.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2005.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "December 2005" Includes bibliographical references.

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19

Montserrat, i. Sangrà Sara. "Ex vivo and in vitro studies on Toll like receptors in canine Leishmania infection." Doctoral thesis, Universitat Autònoma de Barcelona, 2018. http://hdl.handle.net/10803/665953.

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La leishmaniosis canina (CanL) es una enfermedad causada por el protozoa Leishmania infantum. Las manifestaciones clínicas en el perro son muy variables, abarcan desde una infección subclínica a un cuadro severo, que puede ser fatal. Al ser una enfermedad compleja, es difícil de diagnosticar. La respuesta inmunitaria de cada individuo juega un papel muy importante, tanto para el diagnóstico como para su tratamiento. Los receptores tipo Toll (TLRs) son los principales iniciadores de la respuesta inmunitaria innata cuya función es frenar cualquier intrusión de agentes extraños al cuerpo. Sin emb

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20

Chang, Serena Soyoung Yunmee. "Toll-Like Receptors: Target of Hepatitis C Virus: A Dissertation." eScholarship@UMMS, 2008. https://escholarship.umassmed.edu/gsbs_diss/386.

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Hepatitis C Virus (HCV) is the primary cause of liver transplantation due to its chronic nature in up to eighty percent of infected cases. Around 3 percent of the world’s population is infected with HCV. Treatment for HCV is a combined Ribavirin and interferon-α (IFN-α) therapy effective in only fifty to eighty percent of patients depending on HCV genotype. The growing health concern with this disease is the lack of a cure despite liver transplantation. HCV targets hepatocytes, liver cells, but is not cytolytic. HCV has been shown to induce end stage liver disease through sustained inflammatio

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21

POZZI, CHIARA. "Toll-like receptors as mediators of of tumor cell death." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2010. http://hdl.handle.net/10281/7505.

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Recently, it has been demonstrated that invasive but nonpathogenic Salmonella typhimurium i.t. injected into melanoma B16-bearing mice led to complete regression of the tumor, although Salmonella was unable to directly kill B16 tumor cells in vitro. Since we found high levels of IFN-γ in infected tumor masses in vivo, we wondered whether this cytokine might be involved in tumor cell death. In this work, we have demonstrated that IFN-γ shows a cytotoxic effect only when administered in combination with Salmonella. In addition, this combined treatment is able to enhance TLR transcription, mainly

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22

Lange, Margaret J. "Hormonal regulation of innate immune responses and toll-like receptors in the human endometrium." Diss., Columbia, Mo. : University of Missouri-Columbia, 2008. http://hdl.handle.net/10355/5606.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2008.<br>"May 2008" The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. Includes bibliographical references.

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23

Eckl-Dorna, J. "How B cell receptors and Toll-like receptors collaborate in shaping B cell responses." Thesis, University College London (University of London), 2009. http://discovery.ucl.ac.uk/18762/.

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Antigen recognition by B cells results in their activation followed by specific antibody production. These events are initiated by antigen binding to their surface B cell receptors (BCR) which triggers both signalling and internalization of the receptor bound antigen to the endosome. However B cells also express features of the innate immune system such as Toll like receptors (TLRs), that can be located either on the surface of the cell or intracellularly where they recognize bacterial and viral nucleic acids. Engagement of these receptors within B cells is associated with enhancement of humor

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24

Baoprasertkul, Puttharat Liu Zhanjiang. "Characterization of innate immune genes of catfish CXC chemokines and toll-like receptors /." Auburn, Ala., 2006. http://repo.lib.auburn.edu/2006%20Spring/doctoral/BAOPRASERTKUL_PUTTHARAT_14.pdf.

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25

Huhta, H. (Heikki). "Toll-like receptors in Alimentary tract -special reference to Barrett’s esophagus." Doctoral thesis, Oulun yliopisto, 2016. http://urn.fi/urn:isbn:9789526213392.

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Abstract Incidence of esophageal adenocarcinoma is rising rapidly in Western countries. The main risk factor for esophageal adenocarcinoma is Barrett’s esophagus. Barrett’s esophagus results from long-term gastroesophageal reflux disease. The gastrointestinal tract is colonized by bacteria, fungi and viruses forming the alimentary tract microbiome. Microbiome transformation is involved in pathogenesis of alimentary tract cancer and also in the development of Barrett’s metaplasia. Toll-like receptors (TLR) are molecules of the innate immune system and they are involved in bacterial and viral re

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26

Mathew, Manu. "Characterisation of antimicrobial peptides and toll-like receptors in amniotic membranes." Thesis, University of Nottingham, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.716469.

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PURPOSE- Antimicrobial peptides (AMPs) are cationic host defence peptides with microbicidal properties providing a "chemical barrier" in response to pathogens and various pathological states. They show promise as potential therapeutic agents. Amniotic membrane (AM) transplantation is indicated in ocular surface surgery procedure. However, little is known of the AMP profile and variability within the AM. In addition, the effects of processing, storage, and preoperative preparation on AMPs in the transplant ready amniotic membrane (TRAM) are not clear. This can alter the therapeutic potential of

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27

Burkey, Thomas Edward. "Expression of toll-like receptors in porcine immune cells and tissues." Diss., Manhattan, Kan. : Kansas State University, 2006. http://hdl.handle.net/2097/153.

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28

Cao, Fei. "Chlamydia pneumoniae, toll-like receptors and pathogenesis of atherosclerotic heart disease." View the abstract Download the full-text PDF version (on campus access only), 2007. http://etd.utmem.edu/ABSTRACTS/2007-022-Cao-index.html.

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Thesis (Ph.D. )--University of Tennessee Health Science Center, 2007.<br>Title from title page screen (viewed on May 16, 2008 ). Research advisor: Gerald I. Byrne, Ph.D. Document formatted into pages (xi, 114 p. : ill.). Vita. Abstract. Includes bibliographical references (p. 65-107).

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29

Sang, Yongming. "Porcine innate antiviral immunity : host defense peptides and toll-like receptors." Diss., Manhattan, Kan. : Kansas State University, 2008. http://hdl.handle.net/2097/960.

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30

Kanczkowski, Waldemar, Kai Zacharowski, and Stefan R. Bornstein. "Role of Toll-Like Receptors and Inflammation in Adrenal Gland Insufficiency." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135727.

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Adrenal gland insufficiency – the clinical manifestation of deficient production or action of adrenal steroids – is a life-threatening disorder. Among many factors which can predispose to primary adrenal failure, an autoimmune adrenalitis and infectious agents play a major role. The initial host defense against bacterial infections is executed primarily by the pattern recognition receptors, e.g. Toll-like receptors (TLRs), expressed in cells from the innate immune system. Upon activation, TLRs have been found to regulate various levels of innate and adaptive immunity as well as control tissue

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31

Fiola, Stéphanie. "Reconnaissance moléculaire du virus Epstein-Barr par les «Toll-like receptors»." Thesis, Université Laval, 2010. http://www.theses.ulaval.ca/2010/26899/26899.pdf.

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32

Oakes, N. "The expression of toll-like receptors in B-chronic lymphocytic leukaemia." Thesis, University of the West of England, Bristol, 2015. http://eprints.uwe.ac.uk/25452/.

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Chronic Lymphocytic Leukaemia (CLL) is the most common form of Leukaemia in the Western world and has a highly variable clinical course. Continuing advances in the range of therapeutic options available to clinicians require reliable prognostic indicators that can be used to group patients accurately according to their risk of disease progression, thereby allowing meaningful comparisons of treatments. The expression of Toll-Like Receptors (TLR) on cells involved with the disease process in CLL was studied to establish links between levels of expression and the disease process. The expression l

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33

Asquith, Mark. "Toll-like receptors in the induction and regulation of intestinal inflammation." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.526567.

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34

Kanczkowski, Waldemar, Kai Zacharowski, and Stefan R. Bornstein. "Role of Toll-Like Receptors and Inflammation in Adrenal Gland Insufficiency." Karger, 2010. https://tud.qucosa.de/id/qucosa%3A27670.

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Adrenal gland insufficiency – the clinical manifestation of deficient production or action of adrenal steroids – is a life-threatening disorder. Among many factors which can predispose to primary adrenal failure, an autoimmune adrenalitis and infectious agents play a major role. The initial host defense against bacterial infections is executed primarily by the pattern recognition receptors, e.g. Toll-like receptors (TLRs), expressed in cells from the innate immune system. Upon activation, TLRs have been found to regulate various levels of innate and adaptive immunity as well as control tissue

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35

Tuon, Felipe Francisco Bondan. "Identificação e quantificação da expressão de receptores toll-like 2, 4, e 9 na leishmaniose cutânea humana." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5134/tde-02082011-150251/.

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Introdução: Um dos primeiros sistemas de defesa contra os microrganismos é a via dos receptores Toll-like (TLRs). A ativação destes receptores leva à síntese de citocinas, dando início à resposta imune inata. Em modelos animais, o TLR2, TLR4 e TLR9 parecem estar relacionados com o reconhecimento de antígenos de Leishmania. A relação entre TLRs e leishmânia pode ser um mecanismo chave no desenvolvimento da doença ou no controle da mesma. Até o momento não existem estudos de TLRs na leishmaniose cutânea humana. Objetivo: Determinar o padrão de expressão e as células associadas com o TLR2, TLR4 e

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36

Bonfim, Camila Vicente. "Expressão de recptores do tipo Toll e dectina em monocitos e neutrofilos estimulados pelo Paracoccidioides brasiliensis." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309002.

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Orientadores: Maria Heloisa Souza Lima Blotta, Ronei Luciano Mamoni<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-12T03:44:42Z (GMT). No. of bitstreams: 1 Bonfim_CamilaVicente_M.pdf: 3813230 bytes, checksum: eb3f394047f0186a26e4456a537b819c (MD5) Previous issue date: 2008<br>Resumo: A paracoccidioidomicose é uma micose sistêmica causada pelo fungo dimórfico Paracoccidioides brasiliensis, que pode apresentar-se sob diferentes formas clínicas, dependendo da resposta imunológica do hospedeiro. Trabalhos recent

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37

Obando-Pereda, Gustavo Alberto 1978. "Envolvimento dos TLR2 e TLR4 no reconhecimento das partículas de titânio e zircônia por macrofagos murinos." [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/316663.

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Orientador: Dagmar Ruth Stach Machado<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-21T19:21:12Z (GMT). No. of bitstreams: 1 Obando-Pereda_GustavoAlberto_D.pdf: 1140735 bytes, checksum: 2f2e2b586d91ad80806eab9cb7b24bf8 (MD5) Previous issue date: 2012<br>Resumo: A reação biológica as partículas de desgaste é crítica para indução da perda asséptica do implante mediante a osteólise. Deste modo, foi objetivo deste trabalho avaliar o envolvimento dos receptores Toll-like receptors 2 e 4 no reconhecimento das partículas de tit

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38

Shirong, Liu [Verfasser], and Tobias [Akademischer Betreuer] Hartmann. "Toll-Like Receptor 2 and Partner Receptors in Alzheimers Disease / Liu Shirong. Betreuer: Tobias Hartmann." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2012. http://d-nb.info/105222251X/34.

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39

Sales, Maria Lilian. "Impacto dos polimorfismos Pro249Ser do toll-like receptor-6 e Asp299Gly do toll-like receptor-4 sobre a estrutura ventricular esquerda em pacientes hipertensos." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309924.

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Orientador: Wilson Nadruz Júnior<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-15T23:44:37Z (GMT). No. of bitstreams: 1 Sales_MariaLilian_D.pdf: 3937457 bytes, checksum: 1aca22e05bdd5e09c3f3e53c2841451e (MD5) Previous issue date: 2010<br>Resumo: Estudos experimentais revelaram que a inibição de componentes da via de sinalização celular regulada pelos Toll-Like Receptors (TLRs) pode atenuar a hipertrofia cardíaca em animais submetidos à sobrecarga pressora. O objetivo deste estudo foi investigar a influência dos p

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Ferreira, Darkiane Fernandes. "Papel do receptor toll-like 4 no metabolismo lipídico hepático." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5167/tde-26112014-085554/.

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Estudos recentes têm demonstrado uma participação importante do receptor toll-like 4 (TLR4) na evolução de doenças envolvendo desordens metabólicas, como a doença do fígado gorduroso não-alcoólico (NAFLD). No entanto, as alterações do metabolismo lipídico que poderiam ser influenciadas pela ativação do TLR4 são desconhecidas. Neste estudo propomos caracterizar o papel do receptor TLR4 no metabolismo de lipídios no fígado de camundongos deficientes para o receptor de LDL, um modelo que desenvolve NAFLD quando submetido a uma dieta rica em gordura saturada e colesterol. Camundongos controle (C57

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Lin, Miao, and 林苗. "The critical role of toll-like receptor 4 in diabetic nephropathy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B47246637.

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Ahmadi, Farhana. "Interaction of toll-like receptor 4 with the adaptor proteins MAL and TRAM." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610209.

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Morandini, Ana Carolina de Faria. "Avaliação do papel dos receptores TLR2 e TLR4 na produção de citocinas por fibroblastos humanos periodontais deficientes desses receptores." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/25/25149/tde-08012013-172314/.

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Os fibroblastos são atualmente considerados componentes ativos da resposta imune porque estas células expressam receptores do tipo Toll (TLRs), são capazes de reconhecer padrões moleculares associados a patógenos e mediar a produção de citocinas e quimiocinas durante a inflamação. A resposta imune inata do hospedeiro a lipopolissacarídeos (LPS) de Porphyromonas gingivalis é incomum, já que diferentes estudos relataram que este LPS pode ser um agonista para TLR2 e um antagonista ou agonista para TLR4. A sinalização por TLRs envolve proteínas adaptadoras, como MyD88 e TRAM, que são necessárias p

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Burgueño, Banús Juan Francisco. "Understanding the role of Toll-like receptors in the lower gastrointestinal tract." Doctoral thesis, Universitat Autònoma de Barcelona, 2014. http://hdl.handle.net/10803/134668.

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La mucosa del tracte gastrointestinal (TGI) constitueix la superfície de contacte més àmplia de l’organisme amb el medi extern. A la llum del TGI, la barrera epitelial permet la separació entre els bilions de microorganismes residents i els immunòcits. En aquest context, el manteniment de la tolerància a la microbiota resident és essencial per a preservar l’homeòstasi; qualsevol esdeveniment que causi la desregulació d’aquestes interaccions pot desencadenar respostes pro-inflamatòries com les observades a la malaltia inflamatòria intestinal (MII). Els receptors Toll-like (TLR) regulen el diàle

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Seibl, Reinhart. "Toll-like receptors: Studies on cellular activation and involvement in rheumatoid arthritis /." Zürich, 2003. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=15257.

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Lunazzi, Giulia 1981. "Analysis of NFAT5 expression and activity in response to toll-like receptors." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/666120.

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Stimulation of Toll-like receptors (TLRs) in cells of the innate immune system activates the expression of a proinflammatory and antimicrobial gene program controlled by a network of transcriptional regulators. We show that NFAT5, which belongs to the Rel family of transcription factors and was previously characterized as an osmostress responsive factor, is required for the expression of a group of TLR-responsive genes in macrophages, such as Nos2, Il6 and Tnf. NFAT5 recruitment to its target genes is dependent on IKKβ activity, de novo protein synthesis and is sensitive to histone deacetylase

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Bäckhed, Fredrik. "Role of toll-like receptors in host responses to mucosal bacterial infections /." Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-367-8/.

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Pupjain, Srijan. "The impact of Toll-like receptors on antigen presentation by mouse macrophages." Thesis, University of Newcastle Upon Tyne, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491833.

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Toll-like receptors (TLRs) are a group of trans-membrane proteins playing important roles as pattern-recognition receptors (PRRs) of innate immunity that are mainly expressed on professional antigen presenting cells (APCs). Stimulation of APC with TLR ligands, a variety of Jnolecular components derived from microorganisms, triggers innate immunity and establishes adaptive immune responses. I studied the impact of TLR specific for bacterial components on antigen processing and presentation of protective antigen (PA) of B. anthracis by bone marrow macrophages from mice.

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Morris, Gavin Edward. "Mechanisms of airway smooth muscle activation by agonists of toll-like receptors." Thesis, University of Sheffield, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.425196.

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Lacavé-Lapalun, Jean-Victor. "Réponse immunitaire induite par l’irradiation colorectale : manipulation thérapeutique des « toll like receptors »." Paris 6, 2013. http://www.theses.fr/2013PA066249.

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L’exposition aux rayonnements ionisants de la sphère abdomino-pelvienne est associée à une haute incidence de complications. Lors des cas les plus importants, l’apparition d’ulcérations peut entrainer le décès des patients en absence de lourds traitements. Dans ces cas, des essais cliniques sont réalisés avec des Cellules Souches Mésenchymateuses (CSM). Les radiothérapies abdomino-pelvienne peuvent provoquer à court et/ou long terme des effets délétères. Des études démontrent que l’injection de motifs bactériens confère une radioprotection au niveau intestinal. Ils stimulent des récepteurs (To

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