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1
El, Abd, Abd El, Gamel El, and Abd El. "Physico-chemical studies of some aminobenzoic acid hydrazide complexes." Journal of the Serbian Chemical Society 69, no. 4 (2004): 255–64. http://dx.doi.org/10.2298/jsc0404255e.
Анотація:
The stability constants and related thermodynamic functions characterizing the formation of divalent Ni, Cu, Zn, Cd and Hg complexes with o- and p-aminobenzoic acid hydrazide were determined potentiometrically at different temperatures. The formations of the complexes are endothermic processes. The formed bonds are mainly electrostatic. Conductometric titration was carried out to determine the stoichiometry and stability of the formed complexes. The structures of complexes were characterized by their IR, 1H-NMR and 13C-NMR spectra, as well as X-ray diffractograms. The coordination process takes place through the carbonyl group and the terminal hydrazinic amino group. The thermal stability of the complexes was followed in the temperature range 20?600 ?C.
2
Ogboji, Joel, I. Y. Chindo, Aliyu Jauro, D. Boryo, and Lawal N. M. "Formulation, physicochemical evaluation and antimicrobial activity of green toothpaste on streptococcus mutans." International Journal of Advanced Chemistry 6, no. 1 (June 5, 2018): 108. http://dx.doi.org/10.14419/ijac.v6i1.10808.
Анотація:
Background: Toothpaste is a cosmetic product with increasing relevance and demand. However most commercial toothpaste consist of complex chemicals whose health safety remain unclear.Objectives: The present work involves the formulation, and comparative physicochemical evaluation and antimicrobial activity of green toothpaste and three commercial toothpastes (Close-Up, Oral-B and Dabur-Herbal)Methods: The green toothpaste were formulated using Tumeric (Curcuma longa), Aloe Vera (Aloe barbadensis miller), Guava (Psidium guajava), Mint (Mentha piperita), Neem (Azadirachta indica), and Lemon (Citrus lemon) as the active ingredients and comparatively evaluated for various properties like colour, taste, odor, texture, abrasivity, spreadability, cleansing ability, foaming ability, stability, homogeneity, moisture content, gritty matter and pH. The antimicrobial activity of the formula was comparatively tested on Streptococcus mutans (the major causative organism of dental caries).Results: Cold extracts of plant materials with ethanol showed a relative low (3.6% - 6.8%) percentage recovery of bioactive compounds. Physico-chemical tests revealed that the spreadability, pH, foam, gritty matter and homogeneity gave favourable results that compares well with commercial ones. The result of the antimicrobial test shows significant difference between the mean zones of inhibition of the various toothpastes.Conclusion: The results of the study agree with traditional application of the herbaceous plants and showed that the formulated toothpaste contains phytochemicals which possess antimicrobial properties and may be safer compared to toothpaste consisting of synthetic chemicals.
3
Carmo, M., T. Q. Faria, H. Falk, A. S. Coroadinha, M. Teixeira, O. W. Merten, C. Gény-Fiamma, et al. "Relationship between retroviral vector membrane and vector stability." Journal of General Virology 87, no. 5 (May 1, 2006): 1349–56. http://dx.doi.org/10.1099/vir.0.81302-0.
Анотація:
The present work studies the physico-chemical properties of retroviral vector membrane, in order to provide some explanation for the inactivation kinetics of these vectors and to devise new ways of improving transduction efficiency. For this purpose, vectors with an amphotropic envelope produced by TE Fly A7 cells at two culture temperatures (37 and 32 °C) were characterized by different techniques. Electron paramagnetic resonance (EPR) results showed that vectors produced at 32 °C are more rigid than those produced at 37 °C. Further characterization of vector membrane composition allowed us to conclude that the vector inactivation rate increases with elevated cholesterol to phospholipid ratio. Differential scanning calorimetry (DSC) showed that production temperature also affects the conformation of the membrane proteins. Transduction studies using HCT116 cells and tri-dimensional organ cultures of mouse skin showed that vectors produced at 37 °C have higher stability and thus higher transduction efficiency in gene therapy relevant cells as compared with vectors produced at 32 °C. Overall, vectors produced at 37 °C show an increased stability at temperatures below 4 °C. Since vector membrane physico-chemical properties are affected in response to changes in culture temperature, such changes, along with alterations in medium composition, can be used prospectively to improve the stability and the transduction efficiency of retroviral vectors for therapeutic purposes.
4
Jacinth Mispa, K., K. Anusiya, P. Subramaniam, and R. Murugesan. "Development and Physico-Chemical Characterization of Conducting Polymeric Zirconium Based Advanced Nanocomposite Ion-Exchangers for Environmental Remediation." Nano Hybrids and Composites 20 (April 2018): 121–48. http://dx.doi.org/10.4028/www.scientific.net/nhc.20.121.
Анотація:
Polyaniline-Zr(IV) tungstovanadate and Polyaniline-Zirconium oxide nanocomposite ion -exchangers were synthesized and physico-chemical characterization done by FT-IR-UV spectral studies, XRD, SEM and TGA. These composites are having high mechanical strength, good electrical conductivity and stability than their individual components. The organic polymeric component of the composites provides mechanical as well as chemical stability whereas the inorganic component supports the ion-exchange behavior and thermal stability. Both the inorganic and organic parts are jointly responsible for their improved electrical conductivity. They have more promising ion exchange capacity towards alkali metal halides and have selective adsorption towards Pb(II) ion and these can be used as powerful candidates for water softening
5
Ali Khan, Mohammad Mujahid, and Anish Khan. "Evaluation of Electrochemical Properties, Study of Chemical and Mechanical Stability Supported with Ionic Transport and Surface Charge Density Mechanism of PVC Based Cobalt Tungstate Cation Exchange Membrane." Materials Science Forum 875 (October 2016): 127–36. http://dx.doi.org/10.4028/www.scientific.net/msf.875.127.
Анотація:
The chemical and mechanical stability of membrane play a important role for understanding the mechanism and applications of cobalt tungstate cation exchange membrane. The PVC based cobalt tungstate (CT) membrane has been prepared by different methods like sol-gel, die-casting and others material processing techniques. It has been prepared through the mixing of PVC with cobalt tungstate into a definite ratio (1:3) that shows good mechanical stability. Moreover, the paper is concerned with physico-chemical and electro-chemical characterization of membrane, namely fourier transform infrared spectroscopy (FTIR), x-ray diffraction (XRD), scanning electron microscopy (SEM) and electrochemical studies. The results of characterization and electrochemical studies offered the potential industrial applications of membrane in different areas.
6
Aziz, Ahmad Fairoz, Khuzaimah Nazir, S. F. Ayub, N. I. Adam, Muhd Zu Azhan Yahya, and Ab Malik Marwan Ali. "Effect of Phenylene Diamine Antioxidant on Physico-Chemical Properties of Methyl Grafted Natural Rubber Polymer Electrolytes." Applied Mechanics and Materials 864 (April 2017): 48–53. http://dx.doi.org/10.4028/www.scientific.net/amm.864.48.
Анотація:
0.5 wt.% of N-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine (6PPD) was introduced into polymer electrolytes based on 30% poly(methyl-methacrylate) grafted natural rubber (MG30) in order to reduce the aging factor of MG30. The polymer electrolyte without 6PPD was used as control. All samples were prepared by using solution cast techniques. The effect of 6PPD in the electrolytes was analysed by using TGA, DSC and FTIR. TGA and DSC results revealed the thermal stability of MG30 electrolytes with 6PPD have higher thermal stability but lower glass transition temperature value. FTIR studies confirmed the existence of LiTF in the sample and prove the occurrence of polymer-salt complexation. Deconvolution techniques analysis on FTIR spectra shows the electrolyte sample with 6PPD display more ion dissociation which reflects to higher ionic conductivity.
7
Bruni, Giovanna, Ines Ghione, Vittorio Berbenni, Andrea Cardini, Doretta Capsoni, Alessandro Girella, Chiara Milanese, and Amedeo Marini. "The Physico-Chemical Properties of Glipizide: New Findings." Molecules 26, no. 11 (May 24, 2021): 3142. http://dx.doi.org/10.3390/molecules26113142.
Анотація:
The present work is a concrete example of how physico-chemical studies, if performed in depth, are crucial to understand the behavior of pharmaceutical solids and constitute a solid basis for the control of the reproducibility of the industrial batches. In particular, a deep study of the thermal behavior of glipizide, a hypoglycemic drug, was carried out with the aim of clarifying whether the recognition of its polymorphic forms can really be done on the basis of the endothermic peak that the literature studies attribute to the melting of the compound. A number of analytical techniques were used: thermal techniques (DSC, TGA), X-ray powder diffraction (XRPD), FT-IR spectroscopy and scanning electron microscopy (SEM). Great attention was paid to the experimental design and to the interpretation of the combined results obtained by all these techniques. We proved that the attribution of the endothermic peak shown by glipizide to its melting was actually wrong. The DSC peak is no doubt triggered by a decomposition process that involves gas evolution (cyclohexanamine and carbon dioxide) and formation of 5-methyl-N-[2-(4-sulphamoylphenyl) ethyl] pyrazine-2-carboxamide, which remains as decomposition residue. Thermal treatments properly designed and the combined use of DSC with FT-IR and XRPD led to identifying a new polymorphic form of 5-methyl-N-[2-(4-sulphamoylphenyl) ethyl] pyrazine-2-carboxamide, which is obtained by crystallization from the melt. Hence, our results put into evidence that the check of the polymorphic form of glipizide cannot be based on the temperature values of the DSC peak, since such a peak is due to a decomposition process whose Tonset value is strongly affected by the particle size. Kinetic studies of the decomposition process show the high stability of solid glipizide at room temperature.
8
Bhattacharjee, Manish, Mihir K. Chaudhuri, and Pradip C. Paul. "Synthesis and physico-chemical studies of newer mono and diperoxo heteroligand complexes of vanadium." Canadian Journal of Chemistry 70, no. 8 (August 1, 1992): 2245–48. http://dx.doi.org/10.1139/v92-282.
Анотація:
The synthesis of monoperoxo-vanadium(V) complexes, [VO(O2)QL] (Q = 8-quinolinolate and L = EtOH, DMF, DMSO, or THF), and diperoxovanadates(V), A3[VO(O2)2(HPO4)]•2H2O (A = K or NH4) are described. While the [VO(O2)QL] complexes have been synthesized from the reaction of V2O5 with H2O2 and a solution of 8-quinolinol in different donor solvents (L) at pH ca. 2, the oxodiperoxo(hydrophosphato) vanadate(V) dihydrates, A3,[VO(O2)2(HPO4)]•2H2O, have been prepared from the reaction of V2O5 with H2O2 and phosphoric acid at pH 6 of the reaction medium. The compounds have been characterized by chemical analyses, magnetic susceptibility, and molar conductance measurements, and by IR, laser Raman, 1H NMR, and electronic spectroscopic studies. Evidence has been provided for triangularly bonded peroxide (O22−) and coordinated heteroligands. The existence and stability of the complex [VO(O2)2(HPO4)]3− in solution have been ascertained from solution Raman spectroscopy and conductance measurements.
9
Biernat, Krzysztof, Piotr Bocian, Paweł Bukrejewski, and Krzysztof R. Noworyta. "Application of the Impedance Spectroscopy as a New Tool for Studying Biodiesel Fuel Aging Processes." Energies 12, no. 4 (February 22, 2019): 738. http://dx.doi.org/10.3390/en12040738.
Анотація:
Fatty acid methyl esters (FAME), which are presently the main component of biodiesel fuels, undergo relatively fast oxidation processes. This behavior prevents long term storage of this fuel. From laboratory practices, it transpires that even after a very short period of storage, the oxidative stability of the biodiesel exceeds the values required by European regulations. Therefore, the goal of this work was to devise a parameter (marker) allowing for fast and convenient identification of the chemical stability of biodiesel. Moreover, we were aiming to devise a marker which can also be used for the evaluation of the chemical stability of other hydrocarbon fuels containing biocomponents. To this end, in the presented study, selected biodiesel samples were subjected to controlled aging processes in laboratory conditions at 95 °C and oxygen flow according to the norm. Then, physico-chemical parameters were selected that are critical from the point of view of the fuel practical application. Those included density, refractive index, oxidative stability and resistance to oxidation. The appropriate physico-chemical properties were measured before and after an aging process conducted for various times. Simultaneously, electrochemical impedance spectroscopy (EIS) studies were performed for all the studied samples yielding the electrical parameters of the sample, including resistance, relaxation time and capacitance. Subsequently, a correlation between the results of the EIS studies and the selected critical parameters has been established. The obtained results indicate that the resistance, relaxation time and capacitance of the studied biodiesel fuel increase with aging time. This indicates the formation of long chain compounds with increased polarity. Interestingly, the electrical parameter changes are faster at the early stages of the aging process. This suggests a change of the oxidation mechanism during prolonged aging. The devised methodology of impedimetric biodiesel testing can be proposed as a fast and inexpensive method of fuel chemical stability evaluation, allowing for estimating the useful storage time of biodiesel in real conditions.
10
Chervinskyy, Taras, Oleg Grynyshyn, Roman Prokop, Pavlo Shapoval, and Bohdan Korchak. "Study on the Properties of Semi-Synthetic Motor Oil Castrol 10W-40 after Use in a Diesel Engine." Chemistry & Chemical Technology 15, no. 3 (August 15, 2021): 432–37. http://dx.doi.org/10.23939/chcht15.03.432.
Анотація:
The changes in operational and physico-chemical properties of original and used semi-synthetic motor oil Castrol 10W-40 before and after its use in a diesel engine have been investigated. Derivatographic studies were carried out to examine a thermal stability; IR spectroscopy was used to confirm the presence of oil aging products. The composition of the inorganic part of the studied semi-synthetic oils was established by X-ray fluorescence analysis.
11
Marcondes Fonseca de Marc, Henriette, Lilian Katsue Harada, Matthieu Tubino, Valquíria Miwa Hanai Yoshida, Victor Manuel Balcão, and Marta Maria Duarte Carvalho Vila. "Development and evaluation of physico-chemical stability of cosmetic formulations employing the fruits of the Jussara palm tree (Euterpe edulis Martius): tinting shampoo and exfoliant cream." Biomedical and Biopharmaceutical Research Journal 17, no. 1 (March 2020): 1–17. http://dx.doi.org/10.19277/bbr.17.1.224.
Анотація:
The major goal of this research work was to use the dry extract of the fruits of Jussara palm tree (Euterpe edulis Martius) in the development of a tinting shampoo (0.3% (w/v) anthocyanin extract) and an exfoliating beauty cream integrating granules from the seeds of the fruit (1%, w/v). The dry extract was characterized via determination of the content of anthocyanins by the differential pH method, antioxidant activity by the phospho-molybdenum complex methodology, and antimicrobial activity by the disc-diffusion method. The extraction yield was 2.3% (w/w) (2.25 g dry extract/100 g fruit), with an antioxidant activity of 139.0 ± 5.5% relative to that of ascorbic acid, indicating a high antioxidant capacity. The anthocyanin extract did not exhibit antimicrobial activity. The physico-chemical stability characteristics of both the tinting shampoo and the exfoliating cream were evaluated via accelerated stability studies at 0, 30, 60 and 90 days of storage at 40 ± 2 °C and 75 ± 5% relative humidity. The cosmetic products prepared were stable in relation to the physico-chemical characteristics under the conditions studied.
12
Arilla, Elías, Marta Igual, Javier Martínez-Monzó, Pilar Codoñer-Franch, and Purificación García-Segovia. "Impact of Resistant Maltodextrin Addition on the Physico-Chemical Properties in Pasteurised Orange Juice." Foods 9, no. 12 (December 9, 2020): 1832. http://dx.doi.org/10.3390/foods9121832.
Анотація:
Resistant maltodextrin (RMD) is a water-soluble fibre that can be fermented in the colon and exert prebiotic effects. Therefore, its addition to food and beverage products could be beneficial from both technological and nutritional viewpoints. However, to date, most studies have focused on the stability of the prebiotic fibre rather than its impact in the original food matrices. Therefore, this work aimed to evaluate the addition of RMD on the physico-chemical properties of pasteurised orange juice (with and without pulp). °Brix, pH, acidity, particle size distribution, density, turbidity, rheology, and colour were measured in orange juices with increasing RMD concentrations (2.5, 5, and 7.5%). Control samples without RMD were also prepared. RMD added soluble solids to the orange juice, affecting the °Brix, density, turbidity, and rheology. Slight colour differences were observed, and lower citric acid content was achieved because of orange juice replacement with RMD. Differences in particle size distribution were exclusively because of pulp content. Further studies are needed to elucidate if potential consumers will appreciate such physico-chemical changes in organoleptic terms.
13
Nguyen Hong, Trang, and Hoai Nguyen Thị. "STABILITY STUDIES OF GRANULES FOR ORAL SUSPENSION CONTAINING GLUCOMANNAN FROM AMORPHOPHALLUS PAEONIIFOLIUS (ARACEAE) IN THUA THIEN HUE PROVINCE." Volume 8 Issue 4 8, no. 4 (August 2018): 102–7. http://dx.doi.org/10.34071/jmp.2018.4.15.
Анотація:
Background: Our experiment based on the research and the choice optimal fomula containing insoluble component Glucomannan extracted from Amorphophallus paeoniifolius species. The aim of this study was to evaluate the stability of granules for oral suspension containing Glucomannan. Materials and method: The products were stored in sealed aluminium package at room condition (250C, RH 60% - 75%) for 6 months or at accelerated condition (40 ± 20C, RH 75 ± 5%) for 4 months. After storing, evaluating the physico-chemical characteristics of granules for oral suspension containing Glucomannan such as α – angle, moisture content... Results: The results showed that the products were stable at the above conditions about appearance, moisture content, dispersion state in 3 minutes, level of phase separation, residue ratio after 24 hours according to the fourth edition of Vietnamese Pharmacopoeia. Conclusion: Granules for oral suspension containing Glucomannan were stable during research time. Key words: granule, oral suspension, Glucomannan, stability
14
Palmieri, Elena, Vanessa Arato, Davide Oldrini, Beatrice Ricchetti, Maria Grazia Aruta, Werner Pansegrau, Sara Marchi, et al. "Stability of Outer Membrane Vesicles-Based Vaccines, Identifying the Most Appropriate Methods to Detect Changes in Vaccine Potency." Vaccines 9, no. 3 (March 6, 2021): 229. http://dx.doi.org/10.3390/vaccines9030229.
Анотація:
Ensuring the stability of vaccines is crucial to successfully performing global immunization programs. Outer Membrane Vesicles (OMV) are receiving great attention as vaccine platforms. OMV are complex molecules and few data have been collected so far on their stability. OMV produced by bacteria, genetically modified to increase their spontaneous release, simplifying their production, are also known as Generalized Modules for Membrane Antigens (GMMA). We have performed accelerated stability studies on GMMA from different pathogens and verified the ability of physico-chemical and immunological methods to detect possible changes. High-temperature conditions (100 °C for 40 min) did not affect GMMA stability and immunogenicity in mice, in contrast to the effect of milder temperatures for a longer period of time (37 °C or 50 °C for 4 weeks). We identified critical quality attributes to monitor during stability assessment that could impact vaccine efficacy. In particular, specific recognition of antigens by monoclonal antibodies through competitive ELISA assays may replace in vivo tests for the potency assessment of GMMA-based vaccines.
15
Gaspar-Ovalle, Karla A., Juan V. Cauich-Rodriguez та Armando Encinas. "Physico Chemical Characterization of Nanofibrous Poly(Ε-Caprolactone) Electrospun Templates for Cell Adhesion". MRS Advances 2, № 49 (2017): 2689–94. http://dx.doi.org/10.1557/adv.2017.529.
Анотація:
ABSTRACTNanofibrous mats of poly ε-caprolactone (PCL) were fabricated by electrospinning. The nanofiber structures were investigated and characterized by scanning electron microscope, differential scanning calorimetry, thermogravimetric analysis, dynamic mechanical analysis, static water-contact-angle analysis and mechanical properties. The results showed that the nanofibrous PCL is an ideal biopolymer for cell adhesion, owing to its biocompatibility, biodegradability, structural stability and mechanical properties. Differential scanning calorimetry results showed that the fibrous structure of PCL does not alter its crystallinity. Studies of the mechanical properties, wettability and degradability showed that the structure of the electrospun PCL improved the tensile modulus, tensile strength, wettability and biodegradability of the nanotemplates. To evaluate the nanofibrous structure of PCL on cell adhesion, osteoblasts cells were seeded on these templates. The results showed that both adhesion and proliferation of the cells is viable on these electrospun PCL membranes. Thus electrospinning is a relatively inexpensive and scalable manufacturing technique for submicron to nanometer diameter fibers, which can be of interest in the commodity industry.
16
Jain, Kimi, Gaurav Madhu, Haripada Bhunia, Pramod K. Bajpai, Golok B. Nando, and Mondem S. Reddy. "Physico-mechanical characterization and biodegradability behavior of polypropylene/poly(L-lactide) polymer blends." Journal of Polymer Engineering 35, no. 5 (June 1, 2015): 407–15. http://dx.doi.org/10.1515/polyeng-2014-0179.
Анотація:
Abstract Partially biodegradable polymer films from the blends of polypropylene (PP) and poly(L-lactide) (PLLA) were prepared in an internal mixer by melt blending technique, with and without compatibilizer, maleic anhydride grafted polypropylene (MAPP), followed by compression molding. With regard to tensile properties, 80/20 (PP/PLLA) and 80/20/6 (PP/PLLA/MAPP) were found as the optimum blends with best combination of the ingredients. Therefore, the blend samples, namely, PP80 (80% PP+20% PLLA) and PP80C6 (80% PP+20% PLLA+6 phr MAPP) were selected as ‘optimized’ blends and further characterized for their physical, chemical, morphological, and thermal properties. X-ray diffraction studies showed that neat PP and PP80C6 had the same crystallite size indicating compatibility between PP and PLLA due to MAPP. Fourier transform infrared spectroscopy and scanning electron microsopy investigations revealed that the two polymers were completely immiscible in absence of the compatibilizer. Bacterial biodegradation of the samples was performed by exposure to Pseudomonas stutzeri for 60 days and measured in terms of weight loss, optical density, and thermal stability of the samples before and after degradation. The results showed that 80/20 (PP/PLLA) blends undergo considerable degradation. Reduction in thermal stability of the film samples was also observed through thermogravimetric analysis, which was useful in accelerating their biodegradation.
17
Gautier, Eric, Justine Saillard, Caroline Deshayes, Sandy Vrignaud, Frederic Lagarce, and Thomas Briot. "Stability of a 50 mg/mL Ceftazidime Eye-Drops Formulation." Pharmaceutical Technology in Hospital Pharmacy 3, no. 4 (November 27, 2018): 219–26. http://dx.doi.org/10.1515/pthp-2018-0025.
Анотація:
Abstract Background Microbial keratitis are severe infectionsgenerally linked to risk factors. High-doses antibiotic eye-drops could be required to avoid severe complications. In such cases, hospital pharmacists are in charge of their production given the lack of such formulations on the market. The stability of these antibiotic eye-drops is generally limited to a couple of days and publications generally do not describe addition of microbial preservatives even though it is a European Pharmacopeia requirement. The aim of this study was to describe a new ceftazidime eye-drops formulation at 50 mg/mL with a antimicrobial additive, benzalkonium chloride at 0.04 mg/mL. Methods Physico-chemical studies of this new formulation were performed by a stability indicating HPLC-UV method validated according to ICH standards, osmolality measurements, pH monitoring and visual examinations. Antimicrobial preservative efficacy was evaluated according to the method from the European Pharmacopeia. Results After 75 days at −20 °C followed by 7 days at 4 °C, or after 7 days at 4 °C, the eye-drops were stable. A degradation trend was finally observed at day 14 at 4 °C. Conclusions A new ceftazidime eye-drops formulation is proposed with a stability of 7 days. Outpatients do not need to return to the hospital pharmacy for repeat dispensing, thus possibly improving treatment compliance.
18
D’Huart, Elise, Pauline Lider, Jean Vigneron, and Béatrice Demoré. "Evolution of the Stabilis® Database: Creation of a Level of Evidence for Stability Studies." Pharmaceutical Technology in Hospital Pharmacy 3, no. 1 (March 26, 2018): 3–12. http://dx.doi.org/10.1515/pthp-2018-0002.
Анотація:
AbstractBackgroundStabilis®is an international database on stability and compatibility of drugs. The stability data comes mainly from publications of pharmaceutical journals. As the quality of the published stability studies is not equivalent, the objective of this work was to propose a level of evidence for the physico-chemical stability studies selected for the database.MethodsAt first, we evaluated the main pharmacological class consulted by the users. This work was then divided into 5 steps: (1) updating of the criteria to validate a stability study, (2) creating a grid rating articles, (3) rating of the articles of stability studies for anticancer, antifungal and antiviral drugs by 2 evaluators, (4) creation of new screens in the database to enter rating, to visualize the pictograms and commentaries by the users, (5) creation of a guideline to explain the different levels of evidence.ResultsThe main pharmacological class consulted by Stabilis®users is the anticancer drugs and then antiinfectives. We have selected anticancer, antifungal and antiviral drugs for our study. Two hundred and forty publications were evaluated. The highest level attributed was A for anticancer and antifungal drugs and C for antiviral drugs. This difference can be explained by the fact that the majority of publications about antiviral drugs were older.The most frequent anomalies in the rating of articles were an incomplete or imperfect validation of the analytical method (high value of the coefficient of variation) and a defect in the evaluation of the stability indicating capacity.It must be noted that the level of evidence is not the quality level of the analytical method but the mixture of the quality of the method validation and of the results. This aspect was a choice of the Stabilis®team and seems important because the security of the patient is impacted by both aspects.ConclusionsThis new function contributes to help the Stabilis®users to evaluate the stability data published and to take a decision for their use in daily practice. This function will be progressively extended to other pharmacological classes of injectable drugs and then for non-injectable preparations.
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Kovalevska, I. V., and O. A. Ruban. "Research of physico-chemical and technological properties of thioctic acid." Farmatsevtychnyi zhurnal, no. 6 (August 14, 2018): 71–78. http://dx.doi.org/10.32352/0367-3057.6.16.05.
Анотація:
Characteristics and relevance of article topic. Analysis of the literature data shows that the thioctic acid preparations are widely used in the treatment of various diseases. At it’s parenteral application inter- and intraindividual level at the plasma can vary significantly. Therefore, the bioavailability of thioctic acid according to the results of clinical researches is only 30% and efficacy largely dependent on the technological features of the dosage form manufacturing process.
The goal of paper was researches of the thioctic acid physico-chemical properties for development of composition and technology of solid dosage form with improved bioavailability.
Thioctic acid was the object of the study. The complex of physical, chemical and technological tests were used during researches: microscopic, thermal analyzes studies of bulk density, flowability, compression ratio, hygroscopicity, dissolution.
Conclusions. According to thermal analysis, thermal stability of thioctic acid sample has been established within 20–180 °C. The results can be used for explanation the temperature regime in the preparation of solid dispersions of thioctic acid by the melting method.
Solubility determination according to SP of Ukraine II-ed. and microscopic method showed that the substance is readily soluble in 96% ethanol, which leads to the conclusion about the possibility of preparation thioctic acid solid dispersions by dissolution method.
During researches were established physico-chemical and technological properties of the thioctic acid substance, produced by Shanghai modern pharmaceutical Co., LTD (China). Were established that the substance is hygroscopic as evidenced by the change in appearance and weight. It was determined that the substance does not have a satisfactory yield (Carr index – 1,39, slope angle – 60°), compression ratio is 0,495, which is indicative of the lack of sample strength after the removal of pressure.
The results of the studies suggest that the physicochemical properties of the substance needed modifications in the manufacture of solid dosage forms with thioctic acid.
20
Alam, Manawwer, Eram Sharmin, Naser M. Alandis, and Naushad Ahmad. "Effect of organoclay on structure, morphology, thermal behavior and coating performance of Jatropha oil based polyesteramide." e-Polymers 17, no. 6 (October 26, 2017): 491–500. http://dx.doi.org/10.1515/epoly-2017-0096.
Анотація:
AbstractJatropha oil (JO) is an inedible oil mainly used in biodiesel. We have attempted to prepare a JO-based polyesteramide/clay composite using a one-pot, two-step reaction, for application as a protective coating. The aim of the work is to utilize JO for its value-added application by preparing a JO polyesteramide/clay composite, to investigate the potential of the prepared composite as a protective coating, and also to study the effect of loaded clay on the structure, morphology, thermal stability and coating properties of the composite. The formation of composites was confirmed by Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM) and atomic force microscope (AFM) studies. The coating properties were studied by standard physico-mechanical and corrosion resistance tests in corrosive media (3.5 wt% HCl, 3.5 wt% NaCl and tap water). The thermal stability was assessed by differential scanning calorimetry (DSC), thermogravimetric (TGA) and derivative thermogravimetric (DTG) analyses. The coatings showed good physico-mechanical and corrosion resistance performance and can be safely used up to 275°C. The approach paves way towards an alternate value addition to a non-edible oil.
21
Bonaccorso, Angela, Rosalia Pellitteri, Barbara Ruozi, Carmelo Puglia, Debora Santonocito, Rosario Pignatello, and Teresa Musumeci. "Curcumin Loaded Polymeric vs. Lipid Nanoparticles: Antioxidant Effect on Normal and Hypoxic Olfactory Ensheathing Cells." Nanomaterials 11, no. 1 (January 10, 2021): 159. http://dx.doi.org/10.3390/nano11010159.
Анотація:
Background: Curcumin (Cur) shows anti-inflammatory and antioxidant effects on central nervous system diseases. The aim of this study was to develop Cur-loaded polymeric and lipid nanoparticles for intranasal delivery to enhance its stability and increase antioxidant effect on olfactory ensheathing cells (OECs). Methods: The nanosuspensions were subjected to physico-chemical and technological evaluation through photon correlation spectroscopy (PCS), differential scanning calorimetry (DSC) and UV-spectrophotometry. The cytotoxicity studies of nanosuspensions were carried out on OECs. A viability test was performed after 24 h of exposure of OECs to unloaded and curcumin-loaded nanosuspensions. The potential protective effect of Cur was assessed on hypoxic OECs cells. Uptake studies were performed on the same cell cultures. Thermal analysis was performed to evaluate potential interaction of Cur with a 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) biomembrane model. Results: PCS analysis indicated that lipid and polymeric nanosuspensions showed a mean size of 127.10 and 338.20 nm, respectively, high homogeneity and negative zeta potential. Incorporation of Cur into both nanocarriers increased drug stability up to 135 days in cryoprotected freeze-dried nanosuspensions. Cell viability was improved when hypoxic OECs were treated with Cur-loaded polymeric and lipid nanosuspensions compared with the control. Conclusions: Both nanocarriers could improve the stability of Cur as demonstrated by technological studies. Biological studies revealed that both nanocarriers could be used to deliver Cur by intranasal administration for brain targeting.
22
Houghton, Alan, Ingo Appelhagen, and Cathie Martin. "Natural Blues: Structure Meets Function in Anthocyanins." Plants 10, no. 4 (April 8, 2021): 726. http://dx.doi.org/10.3390/plants10040726.
Анотація:
Choices of blue food colourants are extremely limited, with only two options in the USA, synthetic blue no. 1 and no. 2, and a third available in Europe, patent blue V. The food industry is investing heavily in finding naturally derived replacements, with limited success to date. Here, we review the complex and multifold mechanisms whereby blue pigmentation by anthocyanins is achieved in nature. Our aim is to explain how structure determines the functionality of anthocyanin pigments, particularly their colour and their stability. Where possible, we describe the impact of progressive decorations on colour and stability, drawn from extensive but diverse physico-chemical studies. We also consider briefly how this understanding could be harnessed to develop blue food colourants on the basis of the understanding of how anthocyanins create blues in nature.
23
Eskandari-Nojedehi, Maryam, Hoda Jafarizadeh-Malmiri, and Javad Rahbar-Shahrouzi. "Hydrothermal green synthesis of gold nanoparticles using mushroom (Agaricus bisporus) extract: physico-chemical characteristics and antifungal activity studies." Green Processing and Synthesis 7, no. 1 (February 23, 2018): 38–47. http://dx.doi.org/10.1515/gps-2017-0004.
Анотація:
AbstractEdible mushroom (Agaricus bisporus) extract was used to synthesize gold nanoparticles (AuNPs) through hydrothermal process (at a pressure of 15 psi and a temperature of 121°C for 15 min). Response surface methodology was applied to monitor the influence of the synthesis parameters, namely: the mushroom extract concentration (1–9 gr DP/100 ml distilled water) and the amount of HAuCL4·3H2O solution (8–12 ml) on the particle size and concentration of fabricated AuNPs. The obtained results demonstrated that while the main and quadratic terms of the synthesis parameters had significant (p<0.05) effects on the response variables, their interactions had insignificant effect on them. The results indicated that spherical synthesized AuNPs using 10 ml of HAuCl4·3H2O solution (1 mm) and 1 ml of mushroom extract with concentration of 5 gr DP/100 ml had mean particle size (25 nm) and maximum concentration (534 ppm) and stability (zeta potential of –45.8 mV). The results revealed that mushroom extract could act as both reducing and stabilizing agents due to its bioactive compounds. Fourier-transform infrared analysis showed that polyols and carbonyl groups in mushroom extract had strong effects on formation of stable AuNPs. The fabricated AuNPs exhibited high antifungal activity againstAspergillus flavusas compared to theAspergillus terreus.
24
Senthamizhan, A., K. Sambathkumar, S. Nithiyanantham, and A. A. Alagiriswamy. "Electrical, Optical, Structural Properties with Some Physico-Mechanical of Pure and La3+ Doped L-Alanine Acetate Single Crystals." Sensor Letters 18, no. 12 (December 1, 2020): 894–99. http://dx.doi.org/10.1166/sl.2020.4307.
Анотація:
Slow evaporation was used to successfully generate single crystals of pure and La3+ doped L-alanine acetate from aqueous solution. The structural, vibrational, chemical analysis carried out through XRD, UV, FTIR with FTRaman Analysis. The Nd: YAG laser was used to confirm and estimate the sample’s Second Harmonic Generation (SHG). The growing crystal’s laser damage threshold was also discovered. Thermogravimetic (TG) and Differential theromogravimetric (DTA) studies were used to measure the thermal stability of the formed crystal. The generated LAlA crystals were also subjected to dielectric and photoconductivity tests. The dopant has boosted the efficiency of the L-alanine acetate crystal, according to nonlinear optical studies.
25
Gelli, Rita, Serena Salvestrini, and Francesca Ridi. "Effect of Biologically-Relevant Molecules on the Physico-Chemical Properties of Amorphous Magnesium–Calcium Phosphate Nanoparticles." Journal of Nanoscience and Nanotechnology 21, no. 5 (May 1, 2021): 2872–78. http://dx.doi.org/10.1166/jnn.2021.19049.
Анотація:
The recently-discovered endogenous formation of amorphous magnesium–calcium phosphate nanoparticles (AMCPs) in human distal small intestine occurs in a complex environment, which is rich in biologically-relevant molecules and macromolecules that can shape the properties and the stability of these inorganic particles. In this work, we selected as case studies four diverse molecules, which have different properties and are representative of intestinal luminal components, namely butyric acid, lactose, gluten and peptidoglycan. We prepared AMCPs in the presence of these four additives and we investigated their effect on the features of the particles in terms of morphology, porosity, chemical nature and incorporation/adsorption. The combined use of electron microscopy, infrared spectroscopy and thermal analysis showed that while the morphology and microstructure of the particles do not depend on the type of additive present during the synthesis, AMCPs are able to incorporate a significant amount of peptidoglycan, similarly to the process in which they are involved in vivo.
26
Sakharov, V. N., and P. F. Litvitskiy. "Disorders of Protein Conformation as a Typical Component of Various Human Disease Pathogenesis." Annals of the Russian academy of medical sciences 71, no. 1 (February 16, 2016): 46–51. http://dx.doi.org/10.15690/vramn635.
Анотація:
The review is aimed to analyze the data of the recent studies and to describe all the disorders of protein conformation as a typical pathogenic process of protein structure and metabolism involved in various human disease pathogenesis. The existing group of the disorders of protein metabolism doesn’t clearly reflect the involvement of misfolding in the pathogenesis of many human diseases (as a significant factor) and the term disproteinosis is being broadly used only in the context of some «typical» protein misfolding diseases or conformational diseases (for example, amyloidosis and sickle cell anemia). However, protein conformational stability disorders are well-described as physico-chemical processes; there are diseases, in which the manifestations of protein disorders reach their maximum. The revealing of universal form of conformational stability pathology may eliminate the gaps in the understanding of many human diseases, including some diseases with high social significance.
27
El-Sonbati, Adel Z., Ashraf A. El-Bindary, Mostafa A. Diab, Mohamed A. El-Ela, and Sami A. Mazrouh. "Polymer complexes: XXIV. Physico-chemical studies on coordination and stability in relation to IR data for poly(cinnamaldehyde-anthranilic acid) complexes of d-block elements." Polymer Degradation and Stability 42, no. 1 (January 1993): 1–11. http://dx.doi.org/10.1016/0141-3910(93)90020-j.
28
Miroslava, Fašiangová, BořIlová Gabriela, and Hulánková Radka. "The effect of dietary Se supplementation on the Se status and physico-chemical properties of eggs – a review." Czech Journal of Food Sciences 35, No. 4 (August 30, 2017): 275–84. http://dx.doi.org/10.17221/370/2016-cjfs.
Анотація:
In the last few years, interest in the supplementation of selenium (Se) to animal feed has increased. The results of various studies have shown that eggs with defined selenium content may be used as a new potential source of this scarce element in human nutrition. The selenium content in eggs after dietary supplementation in organic form is about 22–27 µg/egg. This amount represents up to 40–50% of the Recommended Dietary Allowance, which is 55 µg of Se for the adult human. Additionally, due to its antioxidant properties, selenium contributes to the oxidation stability of fat and protein in the eggs of laying hens fed a selenium-supplemented diet. Therefore, selenium addition can affect certain properties of eggs and improve their shelf life. The results of investigations into the physico-chemical properties of different forms of Se have proven that dietary supplementation in the organic form shows higher biological availability than inorganic selenium.
29
Bonaccorso, Angela, Rosalia Pellitteri, Barbara Ruozi, Carmelo Puglia, Debora Santonocito, Rosario Pignatello, and Teresa Musumeci. "Curcumin Loaded Polymeric vs. Lipid Nanoparticles: Antioxidant Effect on Normal and Hypoxic Olfactory Ensheathing Cells." Nanomaterials 11, no. 1 (January 10, 2021): 159. http://dx.doi.org/10.3390/nano11010159.
Анотація:
Background: Curcumin (Cur) shows anti-inflammatory and antioxidant effects on central nervous system diseases. The aim of this study was to develop Cur-loaded polymeric and lipid nanoparticles for intranasal delivery to enhance its stability and increase antioxidant effect on olfactory ensheathing cells (OECs). Methods: The nanosuspensions were subjected to physico-chemical and technological evaluation through photon correlation spectroscopy (PCS), differential scanning calorimetry (DSC) and UV-spectrophotometry. The cytotoxicity studies of nanosuspensions were carried out on OECs. A viability test was performed after 24 h of exposure of OECs to unloaded and curcumin-loaded nanosuspensions. The potential protective effect of Cur was assessed on hypoxic OECs cells. Uptake studies were performed on the same cell cultures. Thermal analysis was performed to evaluate potential interaction of Cur with a 1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC) biomembrane model. Results: PCS analysis indicated that lipid and polymeric nanosuspensions showed a mean size of 127.10 and 338.20 nm, respectively, high homogeneity and negative zeta potential. Incorporation of Cur into both nanocarriers increased drug stability up to 135 days in cryoprotected freeze-dried nanosuspensions. Cell viability was improved when hypoxic OECs were treated with Cur-loaded polymeric and lipid nanosuspensions compared with the control. Conclusions: Both nanocarriers could improve the stability of Cur as demonstrated by technological studies. Biological studies revealed that both nanocarriers could be used to deliver Cur by intranasal administration for brain targeting.
30
Cai, Xixi, Xiaoli Xie, Nanyan Fu, and Shaoyun Wang. "Physico-Chemical and Antifungal Properties of a Trypsin Inhibitor from the Roots of Pseudostellaria heterophylla." Molecules 23, no. 9 (September 18, 2018): 2388. http://dx.doi.org/10.3390/molecules23092388.
Анотація:
Plant peptidase inhibitors play essential roles in the defense systems of plants. A trypsin inhibitor (PHTI) with a molecular mass of 20.5 kDa was isolated from the fresh roots of the medicinal herb, Pseudostellaria heterophylla. The purification process involved ammonium sulfate precipitation, gel filtration chromatography on Sephadex G50, and ion-exchange chromatography on DEAE 650M. The PHTI contained 3.7% α-helix, 42.1% β-sheets, 21.2% β-turns, and 33% disordered structures, which showed similarity with several Kunitz-type trypsin inhibitors. Inhibition kinetic studies indicated that PHTI was a competitive inhibitor, with a Ki value of 3.01 × 10−9 M, indicating a high affinity to trypsin. The PHTI exhibited considerable stability over a broad range of pH (2–10) and temperatures (20–70 °C); however, metal ions, including Fe3+, Ba2+, Mn2+, and Al3+, could inactivate PHTI to different degrees. Results of fluorescence spectroscopy and circular dichroism showed that Fe3+ could bind to TI with an association constant of 2.75 × 105 M−1 to form a 1:1 complex, inducing conformation changes and inactivation of PHTI. In addition, PHTI could inhibit the growth of the phytopathogens, Colletotrichum gloeosporioides and Fusarium oxysporum, through disruption of the cell membrane integrity. The present study extended research on Pseudostellaria heterophylla proteins and makes PHTI an exploitable candidate as an antifungal protein for further investigation.
31
Wang, Xing-Long, Jia-Bao Liu, Maqsood Ahmad, Muhammad Kamran Siddiqui, Muhammad Hussain, and Muhammad Saeed. "Molecular Properties of Symmetrical Networks Using Topological Polynomials." Open Chemistry 17, no. 1 (October 29, 2019): 849–64. http://dx.doi.org/10.1515/chem-2019-0109.
Анотація:
AbstractA numeric quantity that comprehend characteristics of molecular graph Γ of chemical compound is known as topological index. This number is, in fact, invariant with respect to symmetry properties of molecular graph Γ. Many researchers have established, after diverse studies, a parallel between the physico chemical properties like boiling point, stability, similarity, chirality and melting point of chemical species and corresponding chemical graph. These descriptors defined on chemical graphs are extremely helpful for researchers to conduct regression model like QSAR/QSPR and better understand the physical features, complexity of molecules, chemical and biological properties of underlying compound.In this paper, several structure descriptors of vital importance, namely, first, second, modified and augmented Zagreb indices, inverse and general Randic indices, symmetric division, harmonic, inverse sum and forgotten indices of Hex-derived Meshes (networks) of two kinds, namely, HDN1(n) and HDN2(n) are computed and recovered using general approach of topological polynomials.
32
Ciobanu, Steluta Carmen, Simona Liliana Iconaru, Daniela Predoi, Alina Mihaela Prodan, and Mihai Valentin Predoi. "Physico-Chemical Properties and In Vitro Antifungal Evaluation of Samarium Doped Hydroxyapatite Coatings." Coatings 10, no. 9 (August 27, 2020): 827. http://dx.doi.org/10.3390/coatings10090827.
Анотація:
Hydroxyapatite (HAp) and samarium doped hydroxyapatite, Ca10−xSmx(PO4)6(OH)2, xSm = 0.05, (5SmHAp), coatings were prepared by sol-gel process using the dip coating method. The stability of 5SmHAp suspension was evaluated by ultrasound measurements. Fourier transform infrared spectroscopy (FTIR) was used to examine the optical characteristics of HAp and 5SmHAp nanoparticles in suspension and coatings. The FTIR analysis revealed the presence of the functional groups specific to the structure of hydroxyapatite in the 5SmHAp suspensions and coatings. The morphology of 5SmHAp nanoparticles in suspension was evaluated by transmission electron microscopy (TEM). Moreover, scanning electron microscope (SEM) was used to evaluate the morphology of nanoparticle in suspension and the morphology of the surface on the coating. The SEM and TEM studies on 5SmHAp nanoparticles in suspension showed that our samples consist of nanometric particles with elongated morphology. The SEM micrographs of HAp and 5SmHAp coatings pointed out that the coatings are continuous and homogeneous. The surface morphology of the 5SmHAp coatings was also assessed by Atomic Force Microscopy (AFM) studies. The AFM results emphasized that the coatings presented the morphology of a uniformly deposited layer with no cracks and fissures. The crystal structure of 5SmHAp coating was characterized by X-ray diffraction (XRD). The surface composition of 5SmHAp coating was analyzed by X-ray photoelectron spectroscopy (XPS). The XRD and XPS analysis shown that the Sm3+ ions have been incorporated into the 5SmHAp synthesized material. The antifungal properties of the 5SmHAp suspensions and coatings were studied using Candida albicans ATCC 10231 (C. albicans) fungal strains. The quantitative results of the antifungal assay showed that colony forming unity development was inhibited from the early phase of adherence in the case of both suspensions and coatings. Furthermore, the adhesion, cell proliferation and biofilm formation of the C. albicans were also investigated by AFM, SEM and Confocal Laser Scanning Microscopy (CLSM) techniques. The results highlighted that the C. albicans adhesion and cell development was inhibited by the 5SmHAp coatings. Moreover, the data also revealed that the 5SmHAp coatings were effective in stopping the biofilm formation on their surface. The toxicity of the 5SmHap was also investigated in vitro using HeLa cell line.
33
Khan, Shumaila, Sabahuddin Ahmad, Mohammad Imran Siddiqi, and Bilqees Bano. "Physico-chemical and in-silico analysis of a phytocystatin purified from Brassica juncea cultivar RoAgro 5444." Biochemistry and Cell Biology 94, no. 6 (December 2016): 584–96. http://dx.doi.org/10.1139/bcb-2016-0029.
Анотація:
This study describes the isolation and purification of a phytocystatin from seeds of Brassica juncea (Indian mustard; cultivar RoAgro 5444), which is an important oilseed crop both agriculturally and economically. The protein was purified by gel filtration chromatography with 24.3% yield and 204-fold purification, and visualised by 2D gel electrophoresis. The 18.1 kDa mustard cystatin was highly specific for cysteine proteinases. The plant cystatin inhibited cathepsin B, confirming its role in conferring pest resistance. The inhibitor was highly stable over a pH range of 3–10 and retained significant inhibitory potential up to 70 °C. The stoichiometry of its interaction with papain, determined by isothermal calorimetry, suggests a 1:1 complex. Secondary structural elements calculated by far-UV circular dichroism (CD) spectroscopy show an 18.8% α-helical and 21% β-sheet structure. The protein was a non-competitive inhibitor of thiol proteinases. The Stokes radius and frictional co-efficient were used to describe the shape and size of the protein. Homology modelling and docking studies proposed a prototype illustrating the Brassica phytocystatin mediated papain inhibition. Molecular dynamics (MD) study revealed the excellent stability of the papain–phytocystatin complex during a simulation for 100 ns. Detailed results identify the mustard cystatin as an important member of the phytocystatin family.
34
Pisárčik, Martin, Miloš Lukáč, Josef Jampílek, František Bilka, Andrea Bilková, Ľudmila Pašková, Ferdinand Devínsky, Renáta Horáková, Matěj Březina, and Tomáš Opravil. "Silver Nanoparticles Stabilized with Phosphorus-Containing Heterocyclic Surfactants: Synthesis, Physico-Chemical Properties, and Biological Activity Determination." Nanomaterials 11, no. 8 (July 22, 2021): 1883. http://dx.doi.org/10.3390/nano11081883.
Анотація:
Phosphorus-containing heterocyclic cationic surfactants alkyldimethylphenylphospholium bromides with the alkyl chain length 14 to 18 carbon atoms were used for the stabilization of silver nanodispersions. Zeta potential of silver nanodispersions ranges from +35 to +70 mV, which indicates the formation of stable silver nanoparticles (AgNPs). Long-chain heptadecyl and octadecyl homologs of the surfactants series provided the most intensive stabilizing effect to AgNPs, resulting in high positive zeta potential values and smaller diameter of AgNPs in the range 50–60 nm. A comparison with non-heterocyclic alkyltrimethylphosphonium surfactants of the same alkyl chain length showed better stability and more positive zeta potential values for silver nanodispersions stabilized with heterocyclic phospholium surfactants. Investigations of biological activity of phospholium-capped AgNPs are represented by the studies of antimicrobial activity and cytotoxicity. While cytotoxicity results revealed an increased level of HepG2 cell growth inhibition as compared with the cytotoxicity level of silver-free surfactant solutions, no enhanced antimicrobial action of phospholium-capped AgNPs against microbial pathogens was observed. The comparison of cytotoxicity of AgNPs stabilized with various non-heterocyclic ammonium and phosphonium surfactants shows that AgNPs capped with heterocyclic alkyldimethylphenylphospholium and non-heterocyclic triphenyl-substituted phosphonium surfactants have the highest cytotoxicity among silver nanodispersions stabilized by the series of ammonium and phosphonium surfactants.
35
Cristiano, Maria Chiara, Francesca Froiio, Roberta Spaccapelo, Antonia Mancuso, Steven P. Nisticò, Betty P. Udongo, Massimo Fresta, and Donatella Paolino. "Sulforaphane-Loaded Ultradeformable Vesicles as A Potential Natural Nanomedicine for the Treatment of Skin Cancer Diseases." Pharmaceutics 12, no. 1 (December 19, 2019): 6. http://dx.doi.org/10.3390/pharmaceutics12010006.
Анотація:
Sulforaphane is a multi-action drug and its anticancer activity is the reason for the continuous growth of attention being paid to this drug. Sulforaphane shows an in vitro antiproliferative activity against melanoma and other skin cancer diseases. Unfortunately, this natural compound cannot be applied in free form on the skin due to its poor percutaneous permeation determined by its physico-chemical characteristics. The aim of this investigation was to evaluate ethosomes® and transfersomes® as ultradeformable vesicular carriers for the percutaneous delivery of sulforaphane to be used for the treatment of skin cancer diseases. The physico-chemical features of the ultradeformable vesicles were evaluated. Namely, ethosomes® and transfersomes® had mean sizes <400 nm and a polydispersity index close to 0. The stability studies demonstrated that the most suitable ultradeformable vesicles to be used as topical carriers of sulforaphane were ethosomes® made up of ethanol 40% (w/v) and phospholipon 90G 2% (w/v). In particular, in vitro studies of percutaneous permeation through human stratum corneum and epidermis membranes showed an increase of the percutaneous permeation of sulforaphane. The antiproliferative activity of sulforaphane-loaded ethosomes® was tested on SK-MEL 28 and improved anticancer activity was observed in comparison with the free drug.
36
Stojanovic, Anja, Daniel Kogelnig, Lisa Fischer, Stephan Hann, Markus Galanski, Michael Groessl, Regina Krachler, and Bernhard K. Keppler. "Phosphonium and Ammonium Ionic Liquids with Aromatic Anions: Synthesis, Properties, and Platinum Extraction." Australian Journal of Chemistry 63, no. 3 (2010): 511. http://dx.doi.org/10.1071/ch09340.
Анотація:
Several hydrophobic long-chain quaternary ammonium and phosphonium ionic liquids (ILs) with functionalized aromatic anions were prepared following a metathesis route using tricaprylmethylammonium chloride (Aliquat 336) and trihexyl(tetradecyl)phosphonium chloride (Cyphos IL101) as precursors. The incorporation of aromatic anions bearing hydroxy-, methoxy-, thiol-, and thioether functionalities as well as tetraphenylborate anions resulted in an increased chemical stability of the ILs and an alteration of their physico-chemical properties. Furthermore, aromatic anions significantly decreased the water solubility and water uptake of both ammonium and phosphonium-based ILs. Thiol- and thioether ILs were applied for the extraction of platinum from aqueous phase using liquid phase micro-extraction. Time dependent studies showed a rapid elimination of up to 95% platinum after 30 min. With a leaching of the anion <0.01 wt-% into the aqueous media, the evaluated ILs were found to be suitable as extracting agents for platinum from aqueous solutions.
37
Knoll, Andrew H., and John Bauld. "The evolution of ecological tolerance in prokaryotes." Earth and Environmental Science Transactions of the Royal Society of Edinburgh 80, no. 3-4 (1989): 209–23. http://dx.doi.org/10.1017/s0263593300028650.
Анотація:
ABSTRACTThe ecological ranges of Archaeobacteria and Eubacteria are constrained by a requirement for liquid water and the physico-chemical stability limits of biomolecules, but within this broad envelope, prokaryotes have evolved adaptations that permit them to tolerate a remarkable spectrum of habitats. Laboratory experiments indicate that prokaryotes can adapt rapidly to novel environmental conditions, yet geological studies suggest early diversification and long-term stasis within the prokaryotic kingdoms. These apparently contradictory perspectives can be reconciled by understanding that, in general, rates and patterns of prokaryotic evolution reflect the developmental history of the Earth's surface environments. Our understanding of modern microbial ecology provides a lens through which our accumulating knowledge of physiology, molecular phylogeny and the Earth's history can be integrated and focussed on the phenomenon of prokaryotic evolution.
38
Chatli, Manish Kumar, Pavan Kumar, Nitin Mehta, Akhilesh K. Verma, Devendra Kumar, and Om Prakash Malav. "Quality characteristics and storage stability of emu meat nuggets formulated with finger millet (Eleusine coracana) flour." Nutrition & Food Science 45, no. 5 (September 14, 2015): 740–52. http://dx.doi.org/10.1108/nfs-03-2015-0029.
Анотація:
Purpose – The purpose of this study was to develop functional emu meat nuggets incorporated with finger millet flour (FMF) with high fibre content and improved oxidative stability. Design/methodology/approach – FMF was incorporated at 4, 6 and 8 per cent levels with replacement of emu meat in nuggets formulation and on the basis of various physico-chemical, instrumental colour and sensory parameters, 6 per cent FMF was selected as optimum. The functional emu meat nuggets incorporated with optimum level of FMF as well as control were aerobically packaged in low density polyethylene (LDPE) bags and stored for 21 days at refrigeration (4 ± 1°C) and evaluated for oxidative stability, microbiological quality and sensory attributes at regular interval of 7 days. Findings – The fat content showed significant (p < 0.05) decrease, whereas the crude fibre content increased significantly (p < 0.05) with the increasing levels of incorporation. The sensory scores for all the attributes in 6 per cent FMF-incorporated product were higher than control. During entire storage studies, the thiobarbituric acid reactive substances (TBARS), free fatty acid and peroxide value followed an increasing trend for control as well as treatment product; however, treatment showed a significantly (p < 0.05) lower value than control throughout the storage period. Standard plate count increased significantly (p < 0.05) for control and treatment product, but the counts were lower than the prescribed limits even on 21st day of storage. Practical implications – The developed products will have functional value by increasing the calcium and dietary fibre content by utilizing the minor cereals. This will be highly beneficial to both the agriculture and meat industry. Originality/value – The research findings demonstrated the use of FMF in the development of calcium- and fibre-enriched emu meat nuggets with improved oxidative stability.
39
Turkovic, Nemanja, Branka Ivkovic, Jelena Kotur-Stevuljevic, Milica Tasic, Bojan Marković, and Zorica Vujic. "Molecular Docking, Synthesis and anti-HIV-1 Protease Activity of Novel Chalcones." Current Pharmaceutical Design 26, no. 8 (April 23, 2020): 802–14. http://dx.doi.org/10.2174/1381612826666200203125557.
Анотація:
Background: Since the beginning of the HIV/AIDS epidemic, 75 million people have been infected with the HIV and about 32 million people have died of AIDS. Investigation of the molecular mechanisms critical to the HIV replication cycle led to the identification of potential drug targets for AIDS therapy. One of the most important discoveries is HIV-1 protease, an enzyme that plays an essential role in the replication cycle of HIV. Objective: The aim of the present study is to synthesize and investigate anti-HIV-1 protease activity of some chalcone derivatives with the hope of discovering new lead structure devoid drug resistance. Methods: 20 structurally similar chalcone derivatives were synthesized and their physico-chemical characterization was performed. Binding of chalcones to HIV-1 protease was investigated by fluorimetric assay. Molecular docking studies were conducted to understand the interactions. Results: The obtained results revealed that all compounds showed anti-HIV-1 protease activity. Compound C1 showed the highest inhibitory activity with an IC50 value of 0.001 μM, which is comparable with commercial product Darunavir. Conclusion: It is difficult to provide general principles of inhibitor design. Structural properties of the compounds are not the only consideration; ease of chemical synthesis, low molecular weight, bioavailability, and stability are also of crucial importance. Compared to commercial products the main advantage of compound C1 is the ease of chemical synthesis and low molecular weight. Furthermore, compound C1 has a structure that is different to peptidomimetics, which could contribute to its stability and bioavailability.
40
Brodziak, Aneta, Jolanta Król, Arkadiusz Matwijczuk, Tomasz Czernecki, Paweł Glibowski, Łukasz Wlazło, and Anna Litwińczuk. "Effect of Sea Buckthorn (Hippophae rhamnoides L.) Mousse on Properties of Probiotic Yoghurt." Applied Sciences 11, no. 2 (January 8, 2021): 545. http://dx.doi.org/10.3390/app11020545.
Анотація:
The stability of the physico-chemical and sensory characteristics of yoghurts during refrigerated storage is important for industry and the consumer. The aim of the study was to evaluate the nutritional value, microbiological quality, sensory properties, and structure of natural probiotic yoghurts made with the addition of sea buckthorn fruit mousse during refrigerated storage. In this study, we produced natural, probiotic organic yoghurts with the addition of superfoods, i.e., sea buckthorn (Hippophae rhamnoides L.) fruit mousse, using ABT-1 probiotic yoghurt starter culture based on Lactobacillus acidophilus LA-5, Bifidobacterium lactis BB-12, and Streptococcus thermophilus. Physico-chemical (acidity, nutritional value, and structure) as well as microbiological and sensory changes occurring during 21-day refrigerated storage were determined. The yoghurts were characterized by high sanitary and hygienic quality during the whole refrigerated storage. Fourier-Transform Infrared (FTIR) spectra were also used in the analyses of the obtained yoghurt samples. The applied yoghurt additive was visible at the spectral level as an increase in the intensity of the characteristic bands for vibrations related to protein, fat, and polysaccharide structures. Sea buckthorn can be used as a modern and unconventional addition to yoghurts with health-promoting properties. Micrographic studies have shown that the addition of sea buckthorn mousse significantly changes the microstructure of the yoghurt. The structure of sea buckthorn to yoghurt seems to be more susceptible to the influence of damaging factors, which is also confirmed by the FTIR test conducted during the storage.
41
Tokhadzé, Nicolas, Philip Chennell, Régis Cueff, and Valérie Sautou. "Do bevacizumab solutions interact with silicone or polyurethane catheters during an infusion through implantable venous access ports?" Journal of The Royal Society Interface 16, no. 158 (September 2019): 20180721. http://dx.doi.org/10.1098/rsif.2018.0721.
Анотація:
This work aims to evaluate the possible impact of interactions between bevacizumab solutions and an implantable port equipped with a silicone or a polyurethane catheter after infusion through a complete infusion set-up in simulated use conditions. Physico-chemical and structural stability of bevacizumab solution was assessed by visual examination, subvisible particles counting, dynamic light scattering, size exclusion chromatography and ion exchange chromatography. Mechanical properties of the catheters were evaluated by measuring Shore A hardness, strain at break, strain at stress and Young's modulus. The physico-chemical surface state of the catheters was assessed by FTIR-ATR spectroscopy, scanning electron microscopy (SEM) and by water contact angle measurement. The analysis of the bevacizumab solution did not highlight any signs of instability or loss of active substance. Mechanical properties of both materials remained unchanged after the infusion. During material analysis, a decrease in water contact angle observed after infusion and was more pronounced for polyurethane catheters than for silicone, possibly due to bevacizumab adsorption or possible leachable extraction from the materials. Surface modifications were also noted at SEM. This study did not highlight any modifications that could alter the quality of the bevacizumab infusion, nor of the infusion catheter in polyurethane or silicone, despite a modification of surface hydrophilicity. Even if after a single infusion, implantable ports remained safe to use, they aim to be used for several infusion of various drugs during their lifetime, and further studies are needed to assess the impact of repeated infusions.
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Brodziak, Aneta, Jolanta Król, Arkadiusz Matwijczuk, Tomasz Czernecki, Paweł Glibowski, Łukasz Wlazło, and Anna Litwińczuk. "Effect of Sea Buckthorn (Hippophae rhamnoides L.) Mousse on Properties of Probiotic Yoghurt." Applied Sciences 11, no. 2 (January 8, 2021): 545. http://dx.doi.org/10.3390/app11020545.
Анотація:
The stability of the physico-chemical and sensory characteristics of yoghurts during refrigerated storage is important for industry and the consumer. The aim of the study was to evaluate the nutritional value, microbiological quality, sensory properties, and structure of natural probiotic yoghurts made with the addition of sea buckthorn fruit mousse during refrigerated storage. In this study, we produced natural, probiotic organic yoghurts with the addition of superfoods, i.e., sea buckthorn (Hippophae rhamnoides L.) fruit mousse, using ABT-1 probiotic yoghurt starter culture based on Lactobacillus acidophilus LA-5, Bifidobacterium lactis BB-12, and Streptococcus thermophilus. Physico-chemical (acidity, nutritional value, and structure) as well as microbiological and sensory changes occurring during 21-day refrigerated storage were determined. The yoghurts were characterized by high sanitary and hygienic quality during the whole refrigerated storage. Fourier-Transform Infrared (FTIR) spectra were also used in the analyses of the obtained yoghurt samples. The applied yoghurt additive was visible at the spectral level as an increase in the intensity of the characteristic bands for vibrations related to protein, fat, and polysaccharide structures. Sea buckthorn can be used as a modern and unconventional addition to yoghurts with health-promoting properties. Micrographic studies have shown that the addition of sea buckthorn mousse significantly changes the microstructure of the yoghurt. The structure of sea buckthorn to yoghurt seems to be more susceptible to the influence of damaging factors, which is also confirmed by the FTIR test conducted during the storage.
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Gisulga, Jessa B. "Production and Quality Evaluation of Probiotic Malunggay (Moringa oleifera Lam.) Ice Cream." JPAIR Multidisciplinary Research 32, no. 1 (July 31, 2018): 67. http://dx.doi.org/10.7719/jpair.v32i1.576.
Анотація:
The study aimed to produce probiotic malunggay ice cream. It further aimed to determine and assess the effects of the probiotic malunggay on the sensory quality of the product, its physico-chemical properties, stability, consumer reaction and the cost of production. The research study used a 3 x 3 factorial experimental type of research in Randomized Complete Block Design (RCBD) with two (2) replicates and with three (3) levels of malunggay, namely, 0%, 15%, and 30% (w/v) and three (3) levels of probiotic cultures 0%, 20%, and 40% (w/v). The findings of the study revealed that sensory evaluation showed that only malunggay was significantly affected by the acceptability of the aforementioned sensory evaluation. When Malunggay was subjected to sensory evaluation, High levels of malunggay elicit low acceptability on its color, taste, flavor, and texture. In terms of pH, and TA of the probiotic malunggay, when it was made into ice cream, such was affected by the levels of the probiotic culture, increased levels of probiotic culture correspond to a higher pH and TA values thus, increased levels of probiotic culture could further increase the initial microbial count of the probiotics in the product. Further studies may be conducted to confirm the storage stability of the probiotic microorganisms over an extended period of frozen storage.
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Mancuso, Antonia, Maria Chiara Cristiano, Massimo Fresta, Daniele Torella, and Donatella Paolino. "Positively Charged Lipid as Potential Tool to Influence the Fate of Ethosomes." Applied Sciences 11, no. 15 (July 30, 2021): 7060. http://dx.doi.org/10.3390/app11157060.
Анотація:
Ethosomes® are one of the main deformable vesicles proposed to overcome the stratum corneum. They are composed of lecithin, ethanol and water, resulting in round vesicles characterized by a narrow size distribution and a negative surface charge. Taking into account their efficiency to deliver drugs into deeper skin layers, the current study was designed to evaluate the influence of different lipids on the physico-chemical features of traditional ethosomes in the attempt to influence their fate. Three lipids (DOPE, DSPE and DOTAP) were used for the study, but only DOTAP conferred a net positive charge to ethosomes, maintaining a narrow mean size lower than 300 nm and a good polydispersity index. Stability and in vitro cytotoxic studies have been performed using Turbiscan Lab analysis and MTT dye exclusion assay, respectively. Data recorded demonstrated the good stability of modified ethosomes and a reasonable absence of cell mortality when applied to human keratinocytes, NCTC 2544, which are used as a cell model. Finally, the best formulations were selected to evaluate their ability to encapsulate drugs, through the use of model compounds. Cationic ethosomes encapsulated oil red o and rhodamine b in amounts comparable to those recorded from conventional ethosomes (over 50%). Results recorded from this study are encouraging as cationic ethosomes may open new opportunities for skin delivery.
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Zachwieja, A., T. Szulc, A. Potkański, R. Mikuła, W. Kruszyński, and A. Dobicki. "Effect of different fat supplements used during dry period of cows on colostrum physicochemical properties." Biotehnologija u stocarstvu 23, no. 5-6-2 (2007): 67–75. http://dx.doi.org/10.2298/bah0702067z.
Анотація:
The results of certain studies indicate that a relation exists between the quality of colostrum and milk and the correct balancing of energy and protein in the diet for cows in particular during the last three weeks before parturition. The aim of this study was to determine the effect of fat additives offered to cows during the dry period on the composition and physico-chemical properties of colostrum and the pre-colostrum secretion. 24 cows were assigned to one of three groups. Group I - control, received no feed additives; II - received feed supplemented by a mixture of fish and rapeseed oil in a 1:1 ratio, III - received feed supplemented by protected fat (Brgafat). In both cases the addition of fat amounted to 360g, i.e. 2% DM. All animals received a PMR concentrate in quantities calculated according to the INRA system. From all the cows samples were taken about 48 hours before parturition of the pre-colostrum secretion and directly after calving of colostrum from the first, complete milking. The samples taken were analyzed for basic composition, for the overall number of microorganisms (ONM), somatic cell count (SSC), content of urea, coagulation time after adding rennet, thermo stability as well as potential (oSH) and active (pH) acidity. The results of the studies conducted indicate that the composition and physico-chemical properties of colostrum and pre-colostrum is differentiated. Offering protected fat as a feed additive for cows during the last three weeks of the dry period had a significant effect on the share of dry matter and crude protein in the colostrum produced. The addition of a mixture of fish and rapeseed oil did not have a similar effect.
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Bououden, Walid, and Yacine Benguerba. "Computational Quantum Chemical Study, Drug-Likeness and In Silico Cytotoxicity Evaluation of Some Steroidal Anti-Inflammatory Drugs." Journal of Drug Delivery and Therapeutics 10, no. 3-s (June 15, 2020): 68–74. http://dx.doi.org/10.22270/jddt.v10i3-s.4165.
Анотація:
This paper contains a theoretical study of ten Anti-inflammatory steroids (AIS) on the understanding of the relationship between the structure and activity of the drug, the pharmacokinetic parameters responsible for bioavailability and bioactivity and finally the toxicity evaluation. DFT calculations with B3LYP/6-31G (d, p) level have been used to analyze the electronic and geometric characteristics deduced for the stable structure of the compounds. Moreover, using the Frontier Molecular orbital (FMO) energies, MEP surface visualizations and the density-based descriptors such as chemical potential (µ), electronegativity (χ), hardness (η) and softness (σ), the chemical stability were determined. Furthermore, in silico, studies showed that Lipinski rules are applied, which means that these (AIS) are expected to have a high probability of good oral bioavailability. On the other side, the bioinformatic Osiris/Molinspiration analyses of the relative cytotoxicity of these derivatives are reported in comparison to Cortisol. In fact, it has been showed that almost of these compounds are non-toxics except for Mometasone that presents a great risk of tumorigenicity during reproduction with a slightly mutagenic structure due to the two chloride atoms. from all results obtained, we can conclude that fluticasone has the best physico-chemical properties which explains its high efficiency.
Keywords: Anti-inflammatory steroids, DFT, Lipinski rules, Tumorigenicity.
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Radulescu, Matilda, Crinela Utescu, Florin Borcan, Victor Dumitrascu, Dan Navolan, Ioana Zinuca Pavel, and Dana Stoian. "Characterization and in vitro Evaluation of a New Levonorgestrel Silver Liposomes." Revista de Chimie 71, no. 4 (May 5, 2020): 424–29. http://dx.doi.org/10.37358/rc.20.4.8083.
Анотація:
Levonorgestrel is the most widely used synthetic hormone due in particular to strong progestin and anti-ovulatory effects, without estrogenic effects, being also used in hormone supportive therapy and found in preclinical studies for the prevention / occurrence of malignant processes. In order to be able to eliminate the adverse effects but to benefit at the same time from the beneficial biological effects, the posibility of obtaining effective and safe biocompatible formulations is studied. In the present research silver nanoparticles loaded with lenorgestrel were obtained and were subsequently included in a liposomal transporter system. Physico-chemical characterizations showed good stability of the liposomal systems obtained and dimensions compatible with the biological environment. In vitro data conducted on breast cells (MCF 10A and MCF7) revealed a dose-dependent influence in terms of cell viability with no significant changes at low concentration of samples (0.1 μM), while higher concentration was associated with a decrease of the viable breast adenocarcinoma cells especially in the case of silver nanoparticles.
48
Bordón, María Gabriela, Gabriela Noel Barrera, Maria C. Penci, Andrea Bori, Victoria Caballero, Pablo Ribotta, and Marcela Lilian Martínez. "Microencapsulation of Chia Seed Oil (Salvia hispanica L.) in Spray and Freeze-Dried Whey Protein Concentrate/Soy Protein Isolate/Gum Arabic (WPC/SPI/GA) Matrices." Proceedings 53, no. 1 (September 1, 2020): 22. http://dx.doi.org/10.3390/proceedings2020053022.
Анотація:
Microencapsulation by different drying methods protects chia seed oil (CSO) against oxidative degradation, and ultimately facilitates its incorporation in certain foods. The aim of this work was to analyze the influence of freeze or spray drying, as well as of the coacervation phenomena in a ternary wall material blend—whey protein concentrate/soy protein isolate/gum arabic (WPC/SPI/GA)—on the physico–chemical properties of microencapsulated CSO. Differential scanning calorimetry studies indicated that the onset, peak, and end set temperatures for denaturation events shifted from 72.59, 77.96, and 78.02 to 81.34, 86.01, and 92.58 °C, respectively, in the ternary blend after coacervation. Oxidative stability indexes (OSI) of powders were significantly higher (p < 0.05) for both drying methods after inducing coacervation—from 6.45 to 12.04 h (freeze-drying) and 12.05 to 15.31 h (spray drying)—which was possibly due to the shifted denaturation temperatures after biopolymer interaction. It can be concluded that the ternary WPC/SPI/GA blend constitutes an adequate matrix to encapsulate CSO.
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Di Stefano, Marinelli, Eusepi, Ciulla, Fulle, Filippo, Magliulo, Di Biase, and Cacciatore. "Synthesis and Biological Evaluation of Novel Selenyl and Sulfur-l-Dopa Derivatives as Potential Anti-Parkinson’s Disease Agents." Biomolecules 9, no. 6 (June 18, 2019): 239. http://dx.doi.org/10.3390/biom9060239.
Анотація:
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by loss of dopaminergic neurons at level of substantia nigra pars compacta. To date, there is no cure for this pathology, except for some drugs able to alleviate the symptoms of PD. In this paper we report the synthesis and biological evaluation of novel sulfur- and selenyl-l-Dopa (LD) derivatives (SP1–6) obtained through the amide junction between the amino group of LD and carboxylic moiety of sulfur- and selenyl-organic compounds, which are commercially available. Biological activity was evaluated on human undifferentiated and retinoic acid/phorbol myristyl acetate (RA/PMA)-differentiated SY-SH5Y neuroblastoma cell line using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Antioxidant activity against oxidative stress was measured using nitroblue tetrazolium (NBT) and 2’,7’-dichlorodihydrofluorescein diacetate (H2DCFDA) assays. Finally, physico-chemical characterization and plasma stability studies of SP1–6 were also performed. Biological data revealed that SP6 has a significant protective action against the neurotoxic action of 6-hydroxydopamine (6-OHDA) and H2O2 in a RA/PMA-differentiated SY-SH5Y neuroblastoma cell line that proved to be an effective antioxidant and protective compound. SP6, endowed with a lipophilic nature, low molecular weight, and plasma stability, can easily cross biological membranes via passive diffusion such as through the blood–brain barrier. SP6 has great potential for developing novel pharmacological approach for neurodegenerative diseases, such as PD. Further studies will help define its exact antioxidant mechanism and determine whether the neuroprotective action is mediated or modulated by glutathione peroxidase (GPx).
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Domanina, A. M., M. V. Chernikov, I. P. Remezova, E. F. Stepanova, A. M. Shevchenko та A. V. Morozov. "Preparation of 2-phenyl-9-diethylaminoethylimidazo[1,2-α]benzimidazole dinitrate tablets and development of quality control methods". Drug development & registration 10, № 2 (29 травня 2021): 62–67. http://dx.doi.org/10.33380/2305-2066-2021-10-2-62-67.
Анотація:
Introduction. Currently, for the treatment of gastric ulcer, drugs with a combined effect are used. To eliminate possible side effects of the drugs used, the search for new molecules to create more effective and safe histamine H2 receptors continues. As a possible solution to these problems, we investigated the substance dinitrate of 2-phenyl-9-diethylaminoethylimidazo[1,2-α]benzimidazole (DFDB).Aim. The aim of this study was to obtain 2-phenyl-9-diethylaminoethylimidazo[1,2-α]benzimidazole dinitrate tablets and develop methods for quality control.Materials and methods. The object of study was tablets based on the substance DF DB. The physicochemical and technological properties of the tablet dosage form were studied. Pharmaco-technological and physico-chemical indicators were determined according to the methods of the State Pharmacopoeia of the XIV edition. Identification and quantitative determination of DFDB in tablets was performed by HPLC.Results and discussion. Based on the physico-chemical properties and determination of the main technological indicators of DFDB, an optimal tableting technology has been developed. The optimal composition of tablets has been developed. Identification of tablets is proposed to be carried out using HPLC in comparison with the standard sample of DFDB. Related impurities, according to the data obtained, do not exceed 0.1 %. We found that the tablets do not have an antimicrobial effect. The analyzed tablets correspond to category 3A. The content of DFDB should be from 95 to 105 % of the declared amount in one tablet. During the analysis, we conducted biopharmaceutical and technological studies of the finished dosage form during storage under the conditions of long-term stability testing in polymer cans with screw-on lids. It is shown that the selected composition of excipients and the production technology ensure the stability of the finished dosage form for two years of storage under the observed conditions. To select the tableting technology, the main technological properties of the DFDB substance are analyzed. The choice of excipients and the composition of the film coating was carried out.Conclusion. The technology is developed and standardization of tablets based on the substance DFDB is proposed.