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Статті в журналах з теми "Transfert de Lipides"

Автор: Grafiati

Опубліковано: 30 листопада 2024

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1

Rougé, P., J. P. Borges, R. Culerrier, C. Brulé, A. Didier, and A. Barre. "Les protéines de transfert des lipides : des allergènes importants des fruits." Revue Française d'Allergologie 49, no. 2 (2009): 58–61. http://dx.doi.org/10.1016/j.reval.2009.01.003.

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2

Ghanem, R., A. Bouraoui, M. Berchel, et al. "Lipides cationiques ramifiés pour le transfert de gènes par aérosol appliqué à la mucoviscidose." Revue des Maladies Respiratoires 38, no. 6 (2021): 584–85. http://dx.doi.org/10.1016/j.rmr.2021.02.035.

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3

HAFFRAY, P., C. PINCENT, P. RAULT, and B. COUDURIER. "Domestication et amélioration génétique des cheptels piscicoles français dans le cadre du SYSAAF." INRAE Productions Animales 17, no. 3 (2004): 243–52. http://dx.doi.org/10.20870/productions-animales.2004.17.3.3598.

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Анотація:

Depuis 1991, des entreprises françaises sélectionnent la truite arc-en-ciel, la truite fario, le bar, la daurade et le turbot. Les éleveurs ont développé une expertise collective en matière de génétique quantitative, de contrôle de parenté assisté par empreintes génétiques, de monosexage, d’induction hormonale de la ponte, de triploïdisation et de conservation et congélation des gamètes, dans le cadre du Syndicat des Sélectionneurs Avicoles et Aquacoles Français (SYSAAF). Cette domestication s’appuie sur le transfert de la procédure de sélection sur la croissance PROSPER, élaborée par l’INRA,

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4

MOULOUNGUI, Z., E. LACROUX, C. VACA-GARCIA, and J. PEYDECASTAING. "Destruction des farines animales : valorisation des fractions lipidiques en biolubrifiants et additifs biocarburants, et du résidu protéique (ou de l’ensemble)." INRAE Productions Animales 17, HS (2004): 117–22. http://dx.doi.org/10.20870/productions-animales.2004.17.hs.3637.

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L’objectif des travaux est d’étudier la faisabilité de nouvelles voies d’élimination et de valorisation des farines animales. Nous abordons ici l’étude de deux voies de valorisation complémentaires et indépendantes: d’une part, la valorisation de la fraction lipidique en «biocarburant» et «biolubrifiant» et, d’autre part, celle du résidu délipidé ou de l’ensemble de la matrice dans la fabrication de matériaux polymères. Dans un premier temps, les études développées se proposent de mettre en oeuvre un suivi qualité selon les recommandations de la Direction Générale de l’Alimentation. Ensuite, l

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5

Pellerin-Massicotte, Jocelyne, Bruno Vincent, and Émilien Pelletier. "Évaluation écotoxicologique de la baie des Anglais à Baie-Comeau (Québec)." Water Quality Research Journal 28, no. 4 (1993): 665–86. http://dx.doi.org/10.2166/wqrj.1993.035.

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Résumé La baie des Anglais à Baie-Comeau (Québec) est un site industriel reconnu comme étant contaminé aux hydrocarbures et aux biphényls polychlorés (BPC). Une expérience de transfert à moyen terme de deux bivalves marins, Mya arenaria et Mytilus edulis L., a été réalisée entre un site de référence en aval de la baie des Anglais (Franquelin) et des sites contaminés près de Baie-Comeau suivant un gradient de contamination déterminé selon des données physico-chimiques antérieures. Les analyses chimiques de contaminants ont montré qu’il n’y a pas eu d’enrichissement en hydrocarbures, au mercure

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6

Levine, Tim P. "A lipid transfer protein that transfers lipid." Journal of Cell Biology 179, no. 1 (2007): 11–13. http://dx.doi.org/10.1083/jcb.200709055.

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Very few lipid transfer proteins (LTPs) have been caught in the act of transferring lipids in vivo from a donor membrane to an acceptor membrane. Now, two studies (Halter, D., S. Neumann, S.M. van Dijk, J. Wolthoorn, A.M. de Maziere, O.V. Vieira, P. Mattjus, J. Klumperman, G. van Meer, and H. Sprong. 2007. J. Cell Biol. 179:101–115; D'Angelo, G., E. Polishchuk, G.D. Tullio, M. Santoro, A.D. Campli, A. Godi, G. West, J. Bielawski, C.C. Chuang, A.C. van der Spoel, et al. 2007. Nature. 449:62–67) agree that four-phosphate adaptor protein 2 (FAPP2) transfers glucosylceramide (GlcCer), a lipid that

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7

Valverde, Diana P., Shenliang Yu, Venkata Boggavarapu, et al. "ATG2 transports lipids to promote autophagosome biogenesis." Journal of Cell Biology 218, no. 6 (2019): 1787–98. http://dx.doi.org/10.1083/jcb.201811139.

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During macroautophagic stress, autophagosomes can be produced continuously and in high numbers. Many different organelles have been reported as potential donor membranes for this sustained autophagosome growth, but specific machinery to support the delivery of lipid to the growing autophagosome membrane has remained unknown. Here we show that the autophagy protein, ATG2, without a clear function since its discovery over 20 yr ago, is in fact a lipid-transfer protein likely operating at the ER–autophagosome interface. ATG2A can bind tens of glycerophospholipids at once and transfers lipids robu

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8

Daminelli, Elaine Nunes, Celso Spada, Arício Treitinger, Tatiane Vanessa Oliveira, Maria da Conceição Latrilha, and Raul Cavalcante Maranhão. "Alterations in lipid transfer to High-Density Lipoprotein (HDL) and activity of paraoxonase-1 in HIV+ patients." Revista do Instituto de Medicina Tropical de São Paulo 50, no. 4 (2008): 223–27. http://dx.doi.org/10.1590/s0036-46652008000400007.

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HIV+ patients often develop alterations of the plasma lipids that may implicate in development of premature coronary artery disease. High-density lipoprotein (HDL) has an important role in preventing atherogenesis and the aim of this study was to investigate aspects of HDL function in HIV+ patients. HIV+ patients (n = 48) and healthy control subjects (n = 45) of both sexes with similar age were studied. Twenty-five were not being treated with antiretroviral agents, 13 were under reverse transcriptase inhibitor nucleosidic and non-nucleosidic (NRTI+NNRTI) and 10 were under NRTI + protease inhib

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9

Dougan, Stephanie K., Azucena Salas, Paul Rava, et al. "Microsomal triglyceride transfer protein lipidation and control of CD1d on antigen-presenting cells." Journal of Experimental Medicine 202, no. 4 (2005): 529–39. http://dx.doi.org/10.1084/jem.20050183.

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Microsomal triglyceride transfer protein (MTP), an endoplasmic reticulum (ER) chaperone that loads lipids onto apolipoprotein B, also regulates CD1d presentation of glycolipid antigens in the liver and intestine. We show MTP RNA and protein in antigen-presenting cells (APCs) by reverse transcription–polymerase chain reaction and by immunoblotting of mouse liver mononuclear cells and mouse and human B cell lines. Functional MTP, demonstrated by specific triglyceride transfer activity, is present in both mouse splenocytes and a CD1d-positive mouse NKT hybridoma. In a novel in vitro transfer assa

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10

Bianco, Mariachiara, Giovanni Ventura, Davide Coniglio, et al. "Development of a New Binary Matrix for the Comprehensive Analysis of Lipids and Pigments in Micro- and Macroalgae Using MALDI-ToF/ToF Mass Spectrometry." International Journal of Molecular Sciences 25, no. 11 (2024): 5919. http://dx.doi.org/10.3390/ijms25115919.

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While edible algae might seem low in fat, the lipids they contain are crucial for good health and preventing chronic diseases. This study introduces a binary matrix to analyze all the polar lipids in both macroalgae (Wakame—Undaria pinnatifida, Dulse—Palmaria palmata, and Nori—Porphyra spp.) and microalgae (Spirulina—Arthrospira platensis, and Chlorella—Chlorella vulgaris) using matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS). The key lies in a new dual matrix made by combining equimolar amounts of 1,5-diaminonaphthalene (DAN) and 9-aminoacridine (9AA). This combinatio

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11

WETZER, Barbara, Gerardo BYK, Marc FREDERIC, et al. "Reducible cationic lipids for gene transfer." Biochemical Journal 356, no. 3 (2001): 747. http://dx.doi.org/10.1042/0264-6021:3560747.

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12

WETZER, Barbara, Gerardo BYK, Marc FREDERIC, et al. "Reducible cationic lipids for gene transfer." Biochemical Journal 356, no. 3 (2001): 747–56. http://dx.doi.org/10.1042/bj3560747.

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One of the main challenges of gene therapy remains the increase of gene delivery into eukaryotic cells. We tested whether intracellular DNA release, an essential step for gene transfer, could be facilitated by using reducible cationic DNA-delivery vectors. For this purpose, plasmid DNA was complexed with cationic lipids bearing a disulphide bond. This reduction-sensitive linker is expected to be reduced and cleaved in the reducing milieu of the cytoplasm, thus potentially improving DNA release and consequently transfection. The DNA–disulphide-lipid complexation was monitored by ethidium bromid

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13

Zabner, J. "Cationic lipids used in gene transfer." Advanced Drug Delivery Reviews 27, no. 1 (1997): 17–28. http://dx.doi.org/10.1016/s0169-409x(97)00019-7.

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14

Moreau, P., and D. J. Morré. "Cell-free transfer of membrane lipids." Journal of Biological Chemistry 266, no. 7 (1991): 4329–33. http://dx.doi.org/10.1016/s0021-9258(20)64326-5.

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15

Ismail, Vian, Burkhard Bechinger, Jackie A. Mosely, and John M. Sanderson. "Peptide Lipidation by Acyl Transfer from Membrane Lipids and Lyso-Lipids." Biophysical Journal 106, no. 2 (2014): 296a. http://dx.doi.org/10.1016/j.bpj.2013.11.1726.

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16

Tucker, Torry A., Karoly Varga, Zsuzsa Bebok, et al. "Transient transfection of polarized epithelial monolayers with CFTR and reporter genes using efficacious lipids." American Journal of Physiology-Cell Physiology 284, no. 3 (2003): C791—C804. http://dx.doi.org/10.1152/ajpcell.00435.2002.

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Анотація:

Transient transfection of epithelial cells with lipid reagents has been limited because of toxicity and lack of efficacy. In this study, we show that more recently developed lipids transfect nonpolarized human airway epithelial cells with high efficacy and efficiency and little or no toxicity. Because of this success, we hypothesized that these lipids may also allow transient transfection of polarized epithelial monolayers. A panel of reagents was tested for transfer of the reporter gene luciferase ( LUC) into polarized monolayers of non-cystic fibrosis (non-CF) and CF human bronchial epitheli

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17

Somerharju, Pentti. "Is Spontaneous Translocation of Polar Lipids between Cellular Organelles Negligible?" Lipid Insights 8s1 (January 2015): LPI.S31616. http://dx.doi.org/10.4137/lpi.s31616.

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In most reviews addressing intracellular lipid trafficking, spontaneous diffusion of lipid monomers between the cellular organelles is considered biologically irrelevant because it is thought to be far too slow to significantly contribute to organelle biogenesis. This view is based on intervesicle transfer experiments carried out in vitro with few lipids as well as on the view that lipids are highly hydrophobic and thus cannot undergo spontaneous intermembrane diffusion at a significant rate. However, besides that single-chain lipids can translocate between vesicles in seconds, it has been dem

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18

Wong, Louise H., Alenka Čopič, and Tim P. Levine. "Advances on the Transfer of Lipids by Lipid Transfer Proteins." Trends in Biochemical Sciences 42, no. 7 (2017): 516–30. http://dx.doi.org/10.1016/j.tibs.2017.05.001.

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19

Otomo, Takanori, and Shintaro Maeda. "ATG2A transfers lipids between membranes in vitro." Autophagy 15, no. 11 (2019): 2031–32. http://dx.doi.org/10.1080/15548627.2019.1659622.

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20

Klein, Emmanuel, Christian Leborgne, Miahala Ciobanu, et al. "Nucleic acid transfer with hemifluorinated polycationic lipids." Biomaterials 31, no. 17 (2010): 4781–88. http://dx.doi.org/10.1016/j.biomaterials.2010.02.047.

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21

Zhang, Yongli, Jinghua Ge, Xin Bian, and Avinash Kumar. "Quantitative Models of Lipid Transfer and Membrane Contact Formation." Contact 5 (January 2022): 251525642210960. http://dx.doi.org/10.1177/25152564221096024.

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Анотація:

Lipid transfer proteins (LTPs) transfer lipids between different organelles, and thus play key roles in lipid homeostasis and organelle dynamics. The lipid transfer often occurs at the membrane contact sites (MCS) where two membranes are held within 10–30 nm. While most LTPs act as a shuttle to transfer lipids, recent experiments reveal a new category of eukaryotic LTPs that may serve as a bridge to transport lipids in bulk at MCSs. However, the molecular mechanisms underlying lipid transfer and MCS formation are not well understood. Here, we first review two recent studies of extended synapto

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22

Parrish, Christopher C. "Lipids in Marine Ecosystems." ISRN Oceanography 2013 (April 22, 2013): 1–16. http://dx.doi.org/10.5402/2013/604045.

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Lipids provide the densest form of energy in marine ecosystems. They are also a solvent and absorption carrier for organic contaminants and thus can be drivers of pollutant bioaccumulation. Among the lipids, certain essential fatty acids and sterols are considered to be important determinants of ecosystem health and stability. Fatty acids and sterols are also susceptible to oxidative damage leading to cytotoxicity and a decrease in membrane fluidity. The physical characteristics of biological membranes can be defended from the influence of changing temperature, pressure, or lipid peroxidation

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23

Le Gall, Tony, Mathieu Berchel, Lee Davies, et al. "Aerosol-Mediated Non-Viral Lung Gene Therapy: The Potential of Aminoglycoside-Based Cationic Liposomes." Pharmaceutics 14, no. 1 (2021): 25. http://dx.doi.org/10.3390/pharmaceutics14010025.

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Анотація:

Aerosol lung gene therapy using non-viral delivery systems represents a credible therapeutic strategy for chronic respiratory diseases, such as cystic fibrosis (CF). Progress in CF clinical setting using the lipidic formulation GL67A has demonstrated the relevance of such a strategy while emphasizing the need for more potent gene transfer agents. In recent years, many novel non-viral gene delivery vehicles were proposed as potential alternatives to GL67 cationic lipid. However, they were usually evaluated using procedures difficult or even impossible to implement in clinical practice. In this

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24

Goto, Asako, Aya Mizuike, and Kentaro Hanada. "Sphingolipid Metabolism at the ER-Golgi Contact Zone and Its Impact on Membrane Trafficking." Contact 3 (January 2020): 251525642095951. http://dx.doi.org/10.1177/2515256420959514.

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Анотація:

Proteins and lipids represent the two major constituents of biological membranes. Different organelles have different lipid compositions, which may be crucial for the execution and control of various organelle-specific functions. The interorganellar transport of lipids is dominated by mechanisms that are distinct from the vesicular mechanisms that underlie the interorganellar transport of proteins. Lipid transfer proteins (LTPs) efficiently and accurately mediate the trafficking of membrane lipids at the interfaces between different organelles. In this review, which focuses on sphingolipids, w

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25

Bourgis, Fabienne, and Jean-Claude Kader. "Lipid-transfer proteins: Tools for manipulating membrane lipids." Physiologia Plantarum 100, no. 1 (1997): 78–84. http://dx.doi.org/10.1111/j.1399-3054.1997.tb03456.x.

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26

Bourgis, Fabienne, and Jean-Claude Kader. "Lipid-transfer proteins: Tools for manipulating membrane lipids." Physiologia Plantarum 100, no. 1 (1997): 78–84. http://dx.doi.org/10.1034/j.1399-3054.1997.1000107.x.

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27

Burlakova, E. B. "Membrane lipids in transfer and storage of information." Neurochemistry International 21 (January 1992): A13. http://dx.doi.org/10.1016/0197-0186(92)91943-q.

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28

Bagdade, J. D., M. Ritter, and P. V. Subbaiah. "Marine lipids normalize cholesteryl ester transfer in IDDM." Diabetologia 39, no. 4 (1996): 487–91. http://dx.doi.org/10.1007/s001250050470.

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29

Bagdade, J. D., M. Ritter, and P. V. Subbaiah. "Marine lipids normalize cholesteryl ester transfer in IDDM." Diabetologia 39, no. 4 (1996): 487–91. http://dx.doi.org/10.1007/bf00400682.

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30

Ilies, Marc Antoniu, William A. Seitz, Miron T. Caproiu, Melissa Wentz, Robert E. Garfield, and Alexandru T. Balaban. "Pyridinium-Based Cationic Lipids as Gene-Transfer Agents." European Journal of Organic Chemistry 2003, no. 14 (2003): 2645–55. http://dx.doi.org/10.1002/ejoc.200300106.

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31

Liang, Xiaorong, Jian Liu, Yves LeBlanc, et al. "Electron transfer dissociation of doubly sodiated glycerophosphocholine lipids." Journal of the American Society for Mass Spectrometry 18, no. 10 (2007): 1783–88. http://dx.doi.org/10.1016/j.jasms.2007.07.013.

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32

Lee, Robert J., and Leaf Huang. "Lipidic Vector Systems for Gene Transfer." Critical Reviews in Therapeutic Drug Carrier Systems 14, no. 2 (1997): 34. http://dx.doi.org/10.1615/critrevtherdrugcarriersyst.v14.i2.30.

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33

Li, Song, and Leaf Huang. "Lipidic Supramolecular Assemblies for Gene Transfer." Journal of Liposome Research 6, no. 3 (1996): 589–608. http://dx.doi.org/10.3109/08982109609031138.

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34

Zhao, Yinan, Shubiao Zhang, Yuan Zhang, et al. "Tri-peptide cationic lipids for gene delivery." Journal of Materials Chemistry B 3, no. 1 (2015): 119–26. http://dx.doi.org/10.1039/c4tb01312c.

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35

Mukherjee, Koushik, Joyeeta Sen, and Arabinda Chaudhuri. "Common co-lipids, in synergy, impart high gene transfer properties to transfection-incompetent cationic lipids." FEBS Letters 579, no. 5 (2005): 1291–300. http://dx.doi.org/10.1016/j.febslet.2004.11.116.

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36

NAKANISHI, Toshiaki, Toshiro NISHIDA, Yoshihiko YAMAGUCHI, et al. "Apolipoprotein D: Isolation and Effect on Lipid Transfer Activity." Journal of Japan Atherosclerosis Society 15, no. 4 (1987): 945–49. http://dx.doi.org/10.5551/jat1973.15.4_945.

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37

Saito, Hiroshi, Hidenori Nakamura, Suichi Kato, et al. "Percutaneous in vivo gene transfer to the peripheral lungs using plasmid-liposome complexes." American Journal of Physiology-Lung Cellular and Molecular Physiology 279, no. 4 (2000): L651—L657. http://dx.doi.org/10.1152/ajplung.2000.279.4.l651.

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Анотація:

The purpose of this study was to investigate a new method of in vivo gene transfer to the lung parenchyma by the percutaneous approach. The plasmid that contains the gene for firefly luciferase driven by a cytomegalovirus (CMV) promoter (pCMVL) in combination with cationic lipids was percutaneously injected into the lung parenchyma. Luciferase activities were localized to the lobes of the lung where the plasmids with cationic lipids were injected. Percutaneous injection of the plasmid containing the human endothelin-1 (hET-1) gene driven by a CMV promoter (pRc/CMVhET-1) in combination with cat

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38

Rossi, Sergio, Enrique Isla, Alfredo Martínez-García, et al. "Transfer of seston lipids during a flagellate bloom from the surface to the benthic community in the Weddell Sea." Scientia Marina 77, no. 3 (2013): 397–407. http://dx.doi.org/10.3989/scimar.03835.30a.

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39

Nakano, Minoru. "Determination of Intervesicular Transfer of Lipids by SANS-U." hamon 18, no. 2 (2008): 79–82. http://dx.doi.org/10.5611/hamon.18.79.

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40

Ouali, Mustapha, Jean-Marie Ruysschaert, Caroline Lonez, and Michel Vandenbranden. "Cationic lipids involved in gene transfer mobilize intracellular calcium." Molecular Membrane Biology 24, no. 3 (2007): 225–32. http://dx.doi.org/10.1080/09687860601108911.

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41

Gascón, Alicia R., and Jose Luis Pedraz. "Cationic lipids as gene transfer agents: a patent review." Expert Opinion on Therapeutic Patents 18, no. 5 (2008): 515–24. http://dx.doi.org/10.1517/13543776.18.5.515.

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42

Yu, Haijia, Yinghui Liu, Daniel R. Gulbranson, Alex Paine, Shailendra S. Rathore, and Jingshi Shen. "Extended synaptotagmins are Ca2+-dependent lipid transfer proteins at membrane contact sites." Proceedings of the National Academy of Sciences 113, no. 16 (2016): 4362–67. http://dx.doi.org/10.1073/pnas.1517259113.

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Organelles are in constant communication with each other through exchange of proteins (mediated by trafficking vesicles) and lipids [mediated by both trafficking vesicles and lipid transfer proteins (LTPs)]. It has long been known that vesicle trafficking can be tightly regulated by the second messenger Ca2+, allowing membrane protein transport to be adjusted according to physiological demands. However, it remains unclear whether LTP-mediated lipid transport can also be regulated by Ca2+. In this work, we show that extended synaptotagmins (E-Syts), poorly understood membrane proteins at endopl

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43

Tamura, Yasushi, Shin Kawano, and Toshiya Endo. "Lipid homeostasis in mitochondria." Biological Chemistry 401, no. 6-7 (2020): 821–33. http://dx.doi.org/10.1515/hsz-2020-0121.

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AbstractMitochondria are surrounded by the two membranes, the outer and inner membranes, whose lipid compositions are optimized for proper functions and structural organizations of mitochondria. Although a part of mitochondrial lipids including their characteristic lipids, phosphatidylethanolamine and cardiolipin, are synthesized within mitochondria, their precursor lipids and other lipids are transported from other organelles, mainly the ER. Mitochondrially synthesized lipids are re-distributed within mitochondria and to other organelles, as well. Recent studies pointed to the important roles

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44

Britt, Hannah M., Jackie A. Mosely, and John M. Sanderson. "The influence of cholesterol on melittin lipidation in neutral membranes." Physical Chemistry Chemical Physics 21, no. 2 (2019): 631–40. http://dx.doi.org/10.1039/c8cp06661b.

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45

Toyoda, Kazunori, Hiroshi Nakane, and Donald D. Heistad. "Cationic Polymer and Lipids Augment Adenovirus-Mediated Gene Transfer to Cerebral Arteries In vivo." Journal of Cerebral Blood Flow & Metabolism 21, no. 9 (2001): 1125–31. http://dx.doi.org/10.1097/00004647-200109000-00010.

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Анотація:

Adenovirus-mediated gene transfer to blood vessels is relatively inefficient because binding of adenovirus to vessels is limited. The authors have reported that incorporation of cationic polymer and lipids with adenovirus augments gene transfer to blood vessels ex vivo. In this study, the authors determined whether complexes of adenovirus and cations improve efficiency of gene transfer in vivo. Poly-l-lysine, lipofectamine, or lipofectin was complexed with adenovirus encoding β-galactosidase. Optimum ratios of the cations per adenovirus were determined by gene transfer to fibroblasts. After in

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46

Schrantz, Nicolas, Yuval Sagiv, Yang Liu, Paul B. Savage, Albert Bendelac, and Luc Teyton. "The Niemann-Pick type C2 protein loads isoglobotrihexosylceramide onto CD1d molecules and contributes to the thymic selection of NKT cells." Journal of Experimental Medicine 204, no. 4 (2007): 841–52. http://dx.doi.org/10.1084/jem.20061562.

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Анотація:

The Niemann-Pick type C2 (NPC2) protein is a small, soluble, lysosomal protein important for cholesterol and sphingolipid transport in the lysosome. The immunological phenotype of NPC2-deficient mice was limited to an impaired thymic selection of Vα14 natural killer T cells (NKT cells) and a subsequent reduction of NKT cells in the periphery. The remaining NKT cells failed to produce measurable quantities of interferon-γ in vivo and in vitro after activation with α-galactosylceramide. In addition, thymocytes and splenocytes from NPC2-deficient mice were poor presenters of endogenous and exogen

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47

Ghanbarpour, Alireza, Diana P. Valverde, Thomas J. Melia, and Karin M. Reinisch. "A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis." Proceedings of the National Academy of Sciences 118, no. 16 (2021): e2101562118. http://dx.doi.org/10.1073/pnas.2101562118.

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The autophagy protein ATG2, proposed to transfer bulk lipid from the endoplasmic reticulum (ER) during autophagosome biogenesis, interacts with ER residents TMEM41B and VMP1 and with ATG9, in Golgi-derived vesicles that initiate autophagosome formation. In vitro assays reveal TMEM41B, VMP1, and ATG9 as scramblases. We propose a model wherein membrane expansion results from the partnership of a lipid transfer protein, moving lipids between the cytosolic leaflets of apposed organelles, and scramblases that reequilibrate the leaflets of donor and acceptor organelle membranes as lipids are deplete

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48

NAKANISHI, Toshiaki, Toshiro NISHIDA, Daigo TAHARA, Shoichi AKAZAWA, Seibei MIYAKE, and Shigenobu NAGATAKI. "Purification of Lipid Transfer Protein from Human Plasma and Preparation of Anti Human LTP IgG." Journal of Japan Atherosclerosis Society 15, no. 8 (1988): 1631–37. http://dx.doi.org/10.5551/jat1973.15.8_1631.

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49

Chen, Sijin, Xiaoyan Ding, Chao Sun, et al. "Archaeal Lipids Regulating the Trimeric Structure Dynamics of Bacteriorhodopsin for Efficient Proton Release and Uptake." International Journal of Molecular Sciences 23, no. 13 (2022): 6913. http://dx.doi.org/10.3390/ijms23136913.

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Анотація:

S-TGA-1 and PGP-Me are native archaeal lipids associated with the bacteriorhodopsin (bR) trimer and contribute to protein stabilization and native dynamics for proton transfer. However, little is known about the underlying molecular mechanism of how these lipids regulate bR trimerization and efficient photocycling. Here, we explored the specific binding of S-TGA-1 and PGP-Me with the bR trimer and elucidated how specific interactions modulate the bR trimeric structure and proton release and uptake using long-term atomistic molecular dynamic simulations. Our results showed that S-TGA-1 and PGP-

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50

Finkina, E. I., D. N. Melnikova, I. V. Bogdanov, and T. V. Ovchinnikova. "Lipid Transfer Proteins As Components of the Plant Innate Immune System: Structure, Functions, and Applications." Acta Naturae 8, no. 2 (2016): 47–61. http://dx.doi.org/10.32607/20758251-2016-8-2-47-61.

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Анотація:

Among a variety of molecular factors of the plant innate immune system, small proteins that transfer lipids and exhibit a broad spectrum of biological activities are of particular interest. These are lipid transfer proteins (LTPs). LTPs are interesting to researchers for three main features. The first feature is the ability of plant LTPs to bind and transfer lipids, whereby these proteins got their name and were combined into one class. The second feature is that LTPs are defense proteins that are components of plant innate immunity. The third feature is that LTPs constitute one of the most cl

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