Добірка наукової літератури з теми "Transient function"

In recent years, studying soft errors has become an issue of greater importance. There have been many methods developed that estimate the Soft Error Rate. Those methods are either deterministic or statistical. The proposed deterministic model aims to improve Soft Error Rate estimation by accurately approximating the generated pulse and all subsequent pulses. The generated pulse is approximated by a piecewise function consisting of two Weibull cumulative distribution functions. This method is an improvement over existing methods as it offers high accuracy while requiring less pre-characterization. The proposed algorithm reduces pre-characterization by allowing the beta Weibull parameter to be calculated during runtime using gate parameters such as the gate delay.

Diabetic cystopathy is a chronic and common complication of diabetes with a classical triad of symptoms; decreased bladder sensation, increased bladder capacity and impaired detrusor muscle contractility (Hunter and Moore, 2003). In animal models of diabetes such as streptozotocin-induced diabetes in the rat, abnormalities of bladder function have been reported (Longhurst and Belis, 1986). The prototypic TRPV channel, TRPV1, is activated by capsaicin, which has been shown to cause contraction of the rat bladder (Saitoh et al., 2007), and this is reduced in STZ-diabetic rat bladder (Pinna et al., 1994). Therefore we hypothesize that TRPV1 function will be reduced in the diabetic bladder. The aim of this study are the following: Firstly, to investigate the effect of the streptozotocin (STZ) model of diabetes on a range of TRP channel functions in the urinary bladder smooth muscle preparation using TRP channel agonists and antagonists and to study the neurotransmitters involved in the contractile or relaxant responses. Some studies were also performed on colon tissues. Secondly, to explore the involvement of cholesterol modudation in TRP channel signalling. Thirdly, to study the change in TRP channel response with time following the treatment with streptozotocin. The results showed that the contractile responses to the TRPV1 agonist capsaicin, TRPV4 agonist 4-α-PDD, and TRPA1 agonist allyl isothiocyanate were significantly reduced in diabetic bladder. The selective TRPV1 antagonist, SB-366791, inhibited the contractile responses to capsaicin confirming the involvement of TRPV1 channels. The effect of diabetes is unlikely to be at the level of contractile machinery since the contractile responses to muscarinic receptor agonist carbachol were not significantly reduced in diabetic tissues. It is reported for the first time that the combination of neurokinin 1 and 2 antagonists GR-205171 and SB-207164 inhibited the contractile responses to capsaicin suggesting that a neurokinin may be the neurotransmitter involved in the capsaicin responses. In addition, the reduction of the responses to capsaicin in STZ-induced diabetic tissues occurred not only in urinary bladder but also in colon. Cholesterol-PEG significantly lowered the maximal contractile responses to capsaicin of rat bladder strips. Methyl-β-cyclodextrin, α-cyclodextrin and β-cyclodextrin at the same concentrations enhanced the contractile responses to capsaicin in the control and diabetic rat bladder strips. These effects of cyclodextrin are specific to capsaicin activated contractions and not seen with TRPA1 activation, suggesting that the effects are not mediated downstream of channel activation. Since α-cyclodextrin does not sequester cholesterol, the enhanced responses to cyclodextrins may not be due to the cholesterol modulations. Instead, theses novel findings may possibly occur by changing the local membrane lipid environment of the TRPV1 channel. As early as 36 hours after induction of diabetes by STZ, the contractile responses to capsaicin were significantly reduced in comparison to those of the controls and this reduction persisted until the eight weeks time point. In contrast, responses to the TRPA1 agonist allyl isothiocyanate were not affected at early time points but were reduced one week after STZ treatment. This detailed time course analysis suggests that there are novel mechanisms of modulation of the TRPV1 channels in this STZ model. In conclusion, in the rat urinary bladder or colon preparations, diabetes mellitus using STZ animal model caused 1) the impairment of a number of TRP channel subfamily functions, TRPV1, TRPV4 and TRPA1 but not TRPM8. The combination of NK1 and NK2 antagonists significantly inhibited the responses to capsaicin. This may suggest the involvement of neurokinin in postsynaptic transmission in rat bladder following the activation of TRPV1 channel, 2) the impairment caused by STZ-induced diabetes occurred very early (within 36 hours after diabetes induction) in TRPV1 channel but not TRPA1 channel. There are specific early effects of STZ treatment on TRPV1 channel function at a time when other afferent nerve terminal channels (TRPA1) are functioning normally, suggesting that early onset of dysfunction in TRPV1 signalling may not merely be the consequence of nerve damage, 3) the mechanism of this impairment may not be the effect of neuropathy on neurotransmitter release or nerve damage. Improving the responsiveness of nerves of bladder in diabetic patients might be of therapeutic benefit. The present studies suggest that it is possible to enhance function using indirect modulators such as bradykinin which potentiated the TRPV1 channel function in diabetic rat bladders.

Thesis: S.M., Massachusetts Institute of Technology, Department of Nuclear Science and Engineering, 2014.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (pages 147-149).<br>In this thesis, we investigated the Adiabatic, Theta, and Multigrid Amplitude Function (MAF) methods for solving the Method of Characteristics (MOC) formulation of the time-dependent neutron transport equation. The transient transport versions of the 2D LRA and C5G7 benchmarks were used to assess the performance and accuracy of these methods. We began by deriving the CMFD-accelerated MOC algorithm in 2D steady state form and examining the effects of various MOC and CMFD parameters on eigenvalue convergence. The C5G7 problem showed similar acceleration performance for 2, 4, and 7 CMFD energy group structures. CMFD meshes at or near the pin-cell level resulted in the greatest speedups of 15-45x in run time and 30-240 x in number of MOC iterations for both problems. A relaxation factor on the nonlinear diffusion coefficient was required to maintain stability for both problems with optimum values between 0.4-0.7. A sensitivity study was conducted on the C5G7 and LRA transient problems to understand the effects of time step and spatial mesh sizes on the solution accuracy and run time performance. The shape function time step size had a large effect on the solution accuracy for the MAF and Theta methods in solving the LRA problem. All methods showed moderate sensitivity to the amplitude function step size, where increasing step size shifted the peak power to earlier times. The coarse mesh size did not have a significant effect on solution accuracy, but meshes on the pin-cell level were clearly preferred to reduce run time. The overall run time performance between the three methods was mixed. The MAF and Theta methods displayed ~84% speedup over the Adiabatic method for the LRA problem, but all methods had similar run times for the C5G7 problem. This inconsistency is likely due to the more drastic flux shape change during the LRA transient and the ability of the MAF and Theta methods to more accurately treat the flux shape temporal derivative. These results demonstrate that the Adiabatic, Theta, and MAF methods are computationally efficient methods for solving the time-dependent neutron transport equation and warrant further investigation. There are clear advantages to each method and the optimal method will likely depend on the transient characteristics of the problem being studied.<br>by Samuel Christopher Shaner.<br>S.M.

Takotsubo cardiomyopathy (TTC) is a disease characterized by transient left ventricular (LV) dysfunction and typical wall motion abnormalities in apical parts, without obvious signs of coronary influence. Due to its elusive natural cause and the lack of clarified pathology, further studies are needed. Thirteen patients presented with an episode of TTC, and referred to Örebro University Hospital (USÖ), were prospectively included and investigated by comparisons made at onset (acute phase) against at follow-up three months later (recovery phase). Including echocardiographic measurements, focused on biventricular systolic long-axis function and conventional diastolic function (DF) variables. Systolic improvement was shown, while most DF data were unchanged, suggesting that TTC is mainly a systolic disease affecting both ventricles. Diagnosis should include multidisciplinary engagement, as TTC associates both with emotional stress and pathological markers of physiological stress. In this thesis, such approach was offered to the aforementioned patients; to see if a common denominator could be found, thus, contributing to better handling. Emotional state was assessed, along with an array of cardiac investigations in addition to echocardiography. Acutely, imbalance in the autonomic cardiac control was shown, as well as a trend toward posttraumatic stress, but specific findings allowing conclusions on differential diagnosis could not be demonstrated. By adding another 15 TTC patients (i.e. 28 in total), through collaboration with observers from USA, a retrospective echocardiographic analysis could be done to further study DF; concluding that TTC associates with impairment of conventional DF variables which tends to parallel the systolic recovery, in contrary to the initial result but in line with other causesof LV dysfunction. Magnetic resonance imaging (MRI) is another method of choice at TTC. The USÖ patients had cardiac MRI, thus, a retrospective analysis was done to investigate the effect on LV geometry, both echocardiographic and by MRI; suggesting that TTC is consistently associated with increased LV mass, due to a local impact that seems to follow the change in LVconcentric wall motion.

Stability analysis methods may be categorized by two major stability analysis methods: small-signal stability and transient stability analyses. Transient stability methods are further categorized into two major categories: numerical methods based on numerical integration, and direct methods. The purpose of this thesis is to study and investigate transient stability analysis using a combination of step-by-step and direct methods using Equal Area Criterion. The proposed method is extended for transient stability analysis of multi machine power systems. The proposed method calculates the potential and kinetic energies for all machines in a power system and then compares the largest group of kinetic energies to the smallest groups of potential energies. A decision based on the comparison can be made to determine stability of the power system. The proposed method is used to simulate the IEEE 39 Bus system to verify its effectiveness by comparison to the results obtained by pure numerical methods.