Готові списки джерел за темами / Translational neurodevelopment

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Добірка наукової літератури з теми "Translational neurodevelopment"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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Статті в журналах з теми "Translational neurodevelopment"

Ashitomi, Honoka, Tadashi Nakagawa, Makiko Nakagawa, and Toru Hosoi. "Cullin-RING Ubiquitin Ligases in Neurodevelopment and Neurodevelopmental Disorders." Biomedicines 13, no. 4 (2025): 810. https://doi.org/10.3390/biomedicines13040810.

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Ubiquitination is a dynamic and tightly regulated post-translational modification essential for modulating protein stability, trafficking, and function to preserve cellular homeostasis. This process is orchestrated through a hierarchical enzymatic cascade involving three key enzymes: the E1 ubiquitin-activating enzyme, the E2 ubiquitin-conjugating enzyme, and the E3 ubiquitin ligase. The final step of ubiquitination is catalyzed by the E3 ubiquitin ligase, which facilitates the transfer of ubiquitin from the E2 enzyme to the substrate, thereby dictating which proteins undergo ubiquitination. E

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Millevert, Charissa, Nicholas Vidas-Guscic, Liesbeth Vanherp, et al. "Resting-State Functional MRI and PET Imaging as Noninvasive Tools to Study (Ab)Normal Neurodevelopment in Humans and Rodents." Journal of Neuroscience 43, no. 49 (2023): 8275–93. http://dx.doi.org/10.1523/jneurosci.1043-23.2023.

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Neurodevelopmental disorders (NDDs) are a group of complex neurologic and psychiatric disorders. Functional and molecular imaging techniques, such as resting-state functional magnetic resonance imaging (rs-fMRI) and positron emission tomography (PET), can be used to measure network activity noninvasively and longitudinally during maturation in both humans and rodent models. Here, we review the current knowledge on rs-fMRI and PET biomarkers in the study of normal and abnormal neurodevelopment, including intellectual disability (ID; with/without epilepsy), autism spectrum disorder (ASD), and at

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Bradshaw, Nicholas J., William Hennah, and Dinesh C. Soares. "NDE1 and NDEL1: twin neurodevelopmental proteins with similar ‘nature’ but different ‘nurture’." BioMolecular Concepts 4, no. 5 (2013): 447–64. http://dx.doi.org/10.1515/bmc-2013-0023.

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AbstractNuclear distribution element 1 (NDE1, also known as NudE) and NDE-like 1 (NDEL1, also known as Nudel) are paralogous proteins essential for mitosis and neurodevelopment that have been implicated in psychiatric and neurodevelopmental disorders. The two proteins possess high sequence similarity and have been shown to physically interact with one another. Numerous lines of experimental evidence in vivo and in cell culture have demonstrated that these proteins share common functions, although instances of differing functions between the two have recently emerged. We review the key aspects

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Tikka, Sai Krishna. "Translational significance of neurodevelopment underpinned ‘neurophysiological-cognitive’ biomarkers in schizophrenia." Indian Journal of Psychiatry 67, no. 5 (2025): 482–86. https://doi.org/10.4103/indianjpsychiatry.indianjpsychiatry_310_25.

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Biomarker research helps validate diagnostic entities that are otherwise based on pure clinical sense and prone to subjectivity bias. Biomarker research in the field of schizophrenia and psychoses dates back to more than a century. However, the focus on ‘translational’ biomarkers in schizophrenia is a more recent one, dating to the turn of the last century. The translational biomarker research in schizophrenia encompasses diagnostic markers, endophenotypes, and theranostic markers. A prime objective of translational biomarkers in schizophrenia is to enhance the field of identification of high-

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Magai, Dorcas N., Jaya Chandna, Marie-Laure Volvert, et al. "The PRECISE-DYAD Neurodevelopmental substudy protocol: neurodevelopmental risk in children of mothers with pregnancy complications." Wellcome Open Research 8 (August 5, 2024): 508. http://dx.doi.org/10.12688/wellcomeopenres.19689.2.

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Background Over 250 million children are not reaching their developmental potential globally. The impact of prenatal factors and their interplay with postnatal environmental factors on child neurodevelopment, is still unclear—particularly in low- and middle-income settings. This study aims to understand the impact of pregnancy complications as well as environmental, psychosocial, and biological predictors on neurodevelopmental trajectories. Methods This is an observational cohort study of female and male children (≈3,950) born to women (≈4,200) with and without pregnancy complications (pregnan

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Magai, Dorcas N., Jaya Chandna, Marie-Laure Volvert, et al. "The Precise-DYAD Neurodevelopmental substudy protocol: neurodevelopmental risk in children of mothers with placental complications." Wellcome Open Research 8 (November 9, 2023): 508. http://dx.doi.org/10.12688/wellcomeopenres.19689.1.

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Background: Over 250 million children are not reaching their developmental potential globally. The impact of prenatal factors then influenced by postnatal environmental factors on child neurodevelopment, is still unclear—particularly in low- and middle-income settings. This study aims to understand the impact of placental complications as well as environmental, psychosocial, and biological predictors on neurodevelopmental trajectories. Methods: This is an observational cohort study of female and male children (≈3,950) born to women (≈4,200) with and without placental disorders (pregnancy-induc

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Martino, Sabata, Ilaria di Girolamo, Antonio Orlacchio, Alessandro Datti, and Aldo Orlacchio. "MicroRNA Implications across Neurodevelopment and Neuropathology." Journal of Biomedicine and Biotechnology 2009 (2009): 1–13. http://dx.doi.org/10.1155/2009/654346.

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MicroRNAs (miRNAs) have rapidly emerged as biologically important mediators of posttranscriptional and epigenetic regulation in both plants and animals. miRNAs function through a variety of mechanisms including mRNA degradation and translational repression; additionally, miRNAs may guide gene expression by serving as transcription factors. miRNAs are highly expressed in human brain. Tissue and cell type-specific enrichments of certain miRNAs within the nervous system argue for a biological significance during neurodevelopmental stages. On the other hand, a large number of studies have reported

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Mudd, Austin T., and Ryan N. Dilger. "Early-Life Nutrition and Neurodevelopment: Use of the Piglet as a Translational Model." Advances in Nutrition: An International Review Journal 8, no. 1 (2017): 92–104. http://dx.doi.org/10.3945/an.116.013243.

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Nash, Kevin R., Umesh K. Jinwal, and Krishna Moorthi Bhat. "UBE3A: Bridging the gap between neurodevelopment, neural function, and neurodegenerative woes." Journal of Alzheimer’s Disease 102, no. 1 (2024): 3–10. http://dx.doi.org/10.1177/13872877241283680.

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Post-translational modifications (PTMs) of proteins play a significant role in normal protein function but can also be instrumental in disease pathogenesis. One critical yet under-studied PTM in disease is ubiquitination. Ubiquitin chain addition and substrate specificity are determined by a large spectrum of ubiquitin-ligating and -modifying enzymes, E3 ligases, whose expression levels and activities are tightly regulated in a cell-specific manner. While most ubiquitin chains can target proteins for proteasomal degradation, ubiquitination can contribute to other functions within the cell, inc

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Mignani, Luca, Barbara Gnutti, Daniela Zizioli, and Dario Finazzi. "Coenzyme a Biochemistry: From Neurodevelopment to Neurodegeneration." Brain Sciences 11, no. 8 (2021): 1031. http://dx.doi.org/10.3390/brainsci11081031.

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Coenzyme A (CoA) is an essential cofactor in all living organisms. It is involved in a large number of biochemical processes functioning either as an activator of molecules with carbonyl groups or as a carrier of acyl moieties. Together with its thioester derivatives, it plays a central role in cell metabolism, post-translational modification, and gene expression. Furthermore, recent studies revealed a role for CoA in the redox regulation by the S-thiolation of cysteine residues in cellular proteins. The intracellular concentration and distribution in different cellular compartments of CoA and

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Більше джерел

Дисертації з теми "Translational neurodevelopment"

Cagnetta, Roberta. "The cue induced axonal nascent proteome and its translational control mechanisms in neural wiring." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/275601.

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Axonal protein synthesis is rapidly regulated by extrinsic cues during neural wiring but the full landscape of proteomic changes and their translational control mechanisms remain unknown. The ability to investigate the nascent proteome on subcellular compartments has been hampered by the low sensitivity of existing methodology on quantity-limited samples combined with the difficulty of obtaining sufficient amounts of pure material. By combining pulsed Stable Isotope Labelling by Amino acids in Cell culture (pSILAC) with Single-Pot Solid-Phase-enhanced Sample Preparation (SP3), I have establish

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Guidi, Mònica. "Micro RNA-Mediated regulation of the full-length and truncated isoforms of human neurotrophic tyrosine kinase receptor type 3 (NTRK 3)." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7114.

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Neurotrophins and their receptors are key molecules in the development of the nervous system. Neurotrophin-3 binds preferentially to its high-affinity receptor NTRK3, which exists in two major isoforms in humans, the full-length kinaseactive form (150 kDa) and a truncated non-catalytic form (50 kDa). The two variants show different 3'UTR regions, indicating that they might be differentially regulated at the post-transcriptional level. In this work we explore how microRNAs take part in the regulation of full-length and truncated NTRK3, demonstrating that the two isof

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Brosi, Cornelia. "Functional characterization of the TTF complex and its role in neurodevelopmental disorders." Doctoral thesis, 2021. https://doi.org/10.25972/OPUS-15778.

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The eukaryotic gene expression requires extensive regulations to enable the homeostasis of the cell and to allow dynamic responses due to external stimuli. Although many regulatory mechanisms involve the transcription as the first step of the gene expression, intensive regulation occurs also in the post-transcriptional mRNA metabolism. Thereby, the particular composition of the mRNPs plays a central role as the components associated with the mRNA form a specific “mRNP code” which determines the fate of the mRNA. Many proteins which are involved in this regulation and the mRNA metabolism are af

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Книги з теми "Translational neurodevelopment"

Griffin, James A., Peggy McCardle, and Lisa S. Freund, eds. Executive function in preschool-age children: Integrating measurement, neurodevelopment, and translational research. American Psychological Association, 2016. http://dx.doi.org/10.1037/14797-000.

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Martin, Stéphane, and Frédéric Laumonnier, eds. Translational Research Methods in Neurodevelopmental Disorders. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2569-9.

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Executive Function in Preschool-Age Children: Integrating Measurement, Neurodevelopment, and Translational Research. American Psychological Association, 2015.

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Laumonnier, édéric. Translational Research Methods in Neurodevelopmental Disorders. Springer, 2023.

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Laumonnier, Frederic, and Stéphane Martin. Translational Research Methods in Neurodevelopmental Disorders. Springer, 2022.

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Coyle, Joseph T., James E. Barrett, and Michael Williams. Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders. Cambridge University Press, 2012.

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Coyle, Joseph T., James E. Barrett, and Michael Williams. Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders. Cambridge University Press, 2012.

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Coyle, Joseph T., James E. Barrett, and Michael Williams. Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders. Cambridge University Press, 2012.

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Coyle, Joseph T., James E. Barrett, and Michael Williams. Translational Neuroscience: Applications in Psychiatry, Neurology, and Neurodevelopmental Disorders. Cambridge University Press, 2012.

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Translational neuroscience applications in neurology, psychiatry, and neurodevelopmental disorders. Cambridge University Press, 2012.

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Частини книг з теми "Translational neurodevelopment"

Li, Fei, Mingyu Xu, Juehua Yu, and Miao Cao. "Etiology and Translational Research in Neurodevelopmental Disorders." In Nature, Nurture, and Neurodevelopment. Springer Nature Singapore, 2024. https://doi.org/10.1007/978-981-97-7433-3_2.

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McGowan, Patrick O. "Epigenetic Mechanisms of Perinatal Programming: Translational Approaches from Rodent to Human and Back." In Perinatal Programming of Neurodevelopment. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1372-5_17.

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Griffin, James A., Lisa S. Freund, Peggy McCardle, Rebecca DelCarmen-Wiggins, and Abigail Haydon. "Introduction to Executive Function in Preschool-Age Children." In Executive function in preschool-age children: Integrating measurement, neurodevelopment, and translational research. American Psychological Association, 2016. http://dx.doi.org/10.1037/14797-001.

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Diamond, Adele. "Why improving and assessing executive functions early in life is critical." In Executive function in preschool-age children: Integrating measurement, neurodevelopment, and translational research. American Psychological Association, 2016. http://dx.doi.org/10.1037/14797-002.

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Carlson, Stephanie M., Susan Faja, and Danielle M. Beck. "Incorporating early development into the measurement of executive function: The need for a continuum of measures across development." In Executive function in preschool-age children: Integrating measurement, neurodevelopment, and translational research. American Psychological Association, 2016. http://dx.doi.org/10.1037/14797-003.

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Nelson, Jennifer Mize, Tiffany D. James, Nicolas Chevalier, Caron A. C. Clark, and Kimberly Andrews Espy. "Structure, measurement, and development of preschool executive function." In Executive function in preschool-age children: Integrating measurement, neurodevelopment, and translational research. American Psychological Association, 2016. http://dx.doi.org/10.1037/14797-004.

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Willoughby, Michael T., and Clancy B. Blair. "Longitudinal measurement of executive function in preschoolers." In Executive function in preschool-age children: Integrating measurement, neurodevelopment, and translational research. American Psychological Association, 2016. http://dx.doi.org/10.1037/14797-005.

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Eisenberg, Nancy, and Qing Zhou. "Conceptions of executive function and regulation: When and to what degree do they overlap?" In Executive function in preschool-age children: Integrating measurement, neurodevelopment, and translational research. American Psychological Association, 2016. http://dx.doi.org/10.1037/14797-006.

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Rose, Susan A., Judith F. Feldman, and Jeffery J. Jankowski. "Infant cognitive abilities: Potential building blocks of later executive functions." In Executive function in preschool-age children: Integrating measurement, neurodevelopment, and translational research. American Psychological Association, 2016. http://dx.doi.org/10.1037/14797-007.

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Bell, Martha Ann, and Kimberly Cuevas. "Psychobiology of executive function in early development." In Executive function in preschool-age children: Integrating measurement, neurodevelopment, and translational research. American Psychological Association, 2016. http://dx.doi.org/10.1037/14797-008.

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