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Готові списки джерел за темами / Triazole-3-thiol / Статті в журналах

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Статті в журналах з теми "Triazole-3-thiol"

Автор: Grafiati

Опубліковано: 3 червня 2025

Оновлено: 31 липня 2025

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1

Zozulynets, D. М., A. G. Kaplaushenko, and A. S. Korzhova. "The synthesis of 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol and its interaction with aldehydes." Journal of Organic and Pharmaceutical Chemistry 19, no. 1(73) (2021): 48–52. http://dx.doi.org/10.24959/ophcj.21.188137.

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Анотація:

Aim. To synthesize 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol and study its reactivity in the reactionwith aldehydes.Results and discussion. 4-Amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol was synthesized, and a number of 4-(ethyl, aryl)idenamino derivatives were obtained on its basis.Experimental part. Using a series of four successive reactions based on quinoline-2-carboxylic acid, 4-amino-5-(quinolin-2-yl)-4H-1,2,4-triazole-3-thiol was synthesized; its interaction with aldehydes allowed to obtain a number of 4-(ethyl, aryl)idenamino derivatives. The structure of all compounds s

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2

Safonov, A. A. "Study acute toxicity of 4-(R-amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol in vivo." Farmatsevtychnyi zhurnal, no. 2 (August 14, 2018): 98–101. http://dx.doi.org/10.32352/0367-3057.2.16.06.

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Typically, the system is already known are used as the core for a new substance, which have already proved themselves as potential drugs. So one of these is 1,2,4-triazole ring. The purpose was to study acute toxicity of 4-((R-iden)amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiols and identify possible patterns acute toxicity of the chemical structure of indicators derivatives. In the study of acute contact toxicity was used spreadsheet rapid method for Prozorovsky V. B. Analysis of the results of studies acute toxicity of 1,2,4-triazole derivatives showed that all substanc

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3

Ciesielski, Witold, and Anna Krenc. "Potentiometric Titration of Triazolethiols and Tetrazolethiols with Iodine in Alkaline Medium." Collection of Czechoslovak Chemical Communications 67, no. 8 (2002): 1193–99. http://dx.doi.org/10.1135/cccc20021193.

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The iodimetric determination of triazolethiols and tetrazolethiols in alkaline medium is presented. The volumetric titration with potentiometric end-point detection was applied. The range of determination, in which the error is lower than 1%, is 20-2 000 μmol for 1H-1,2,4-triazole-3-thiol (1), 25-1 000 μmol for 3-phenyl-1H-1,2,4-triazole-5-thiol (2), 25-500 μmol for 4-methyl-5-(trifluoromethyl)-4H-1,2,4-triazole-3-thiol (3), 50-500 μmol for 3-amino-1H-1,2,4-triazole-5-thiol (4), 10-1 000 μmol for sodium (5-mercapto-1H-tetrazol-1-yl)acetate (5), 125-500 μmol for 1-phenyl-1H-tetrazole-5-thiol (6

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4

Khilkovets, A. V. "Investigation of physical and chemical properties of new derivatives of 5-(thiophene-3-ylmethyl)-4R-1,2,4-triazole-3-thiols." Current issues in pharmacy and medicine: science and practice 14, no. 2 (2021): 152–56. http://dx.doi.org/10.14739/2409-2932.2021.2.232334.

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Анотація:

Heterocyclic compounds are one of the most important branches of modern organic chemistry and are widely used in medicine, pharmacy, agriculture, and in the production of new materials. One of these compounds is 1,2,4-triazole, which has attracted the attention of scientists around the world for many years. The aim of the work is to synthesize new derivatives of 5-(thiophene-3-ylmethyl)-4R-1,2,4-triazole-3-thiols and study their physical-chemical properties, conducting primary pharmacological screening. Materials and methods. Organic synthesis classical methods were used in the study, as well

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5

Karpenko, Yu V., and O. I. Panasenko. "Search for antibacterial activity in a number of new S-derivatives (1,2,4-triazole-3(2H)-yl)methyl)thiopyrimidines." Current issues in pharmacy and medicine: science and practice 14, no. 2 (2021): 173–78. http://dx.doi.org/10.14739/2409-2932.2021.2.234565.

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The relevance of the study of 1,2,4-triazole derivatives with pyrimidine fragment is due to the synthesis of potential broad-spectrum antibacterial drugs, low molecular weight inducers of interferon, and antitumor agents, search for molecular descriptors of their structure, important for establishing patterns “structure – biological activity”. The aim of the work is a computer search for the antibacterial action of new hybrids of 1,2,4-triazole-3(2H)-thiol with a pyrimidine fragment in relation to 5 test cultures, to establish the dependence of “structure – action”. Materials and methods. For

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6

Safonov, A. A., and I. S. Nosulenko. "Antiradical activity of novel 4-amino-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol derivatives." Current issues in pharmacy and medicine: science and practice 14, no. 2 (2021): 162–66. http://dx.doi.org/10.14739/2409-2932.2021.2.230129.

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The process of studying free radicals began in the middle of the last century (the free radical theory of aging in 1956). Multiple studies have revealed the effect of free radicals on the cells of the body and the development of various diseases, such as diabetes, autoimmune diseases, diseases of the nervous system, and others. As a result, the term antioxidant has emerged, compounds that reduce and prevent the effects of free radicals. Most of the newly synthesized substances are studied for their antiradical properties. 1,2,4-Triazole derivatives are no exception, which has already proven th

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7

Singh, Ashok Kumar, and Khem Raj Kandel. "Synthesis of Triazole derivative: [4-(benzylideneamino)-5-phenyl -4H-1,2,4 – triazole-3-thiol]." Journal of Nepal Chemical Society 30 (December 19, 2013): 174–77. http://dx.doi.org/10.3126/jncs.v30i0.9391.

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The basic nucleus 4-(amino)-5-phenyl-l-4H-1,2,4-triazole-3-thiol has been synthesized by cyclisation of potassium dithiocarbazinate with hydrazine hydrate using water as solvent under reflux condition for 3-4 h. The compound which has been synthesized successfully was subjected to condensation with benzaldehyde to synthesize 4-(benzylideneamino)-5-phenyl -4H-1,2,4 – triazole-3-thiol (Schiff base). The compounds were confirmed by physical parameters (melting point), chromatographic methods (TLC) and spectroscopic methods (IR and NMR).DOI: http://dx.doi.org/10.3126/jncs.v30i0.9391Journal of Nepa

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8

Fedotov, S. O., A. S. Hotsulia, and Yu V. Karpenko. "Synthesis and analgesic activity of new pyrazole-containing derivatives of 1,2,4-triazole-3-thiol." Current issues in pharmacy and medicine: science and practice 16, no. 3 (2023): 205–12. http://dx.doi.org/10.14739/2409-2932.2023.3.288364.

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Pain represents a primary symptom of numerous diseases and conditions, affecting millions of people worldwide. Effective analgesic medications can alleviate or eliminate pain, thereby enhancing patients’ quality of life and assisting them in resuming normal physical and social activities. However, several existing analgesics may carry unwanted side effects, such as ulcers, blood clotting issues, drowsiness, and more. The development of new analgesics is focused on creating drugs that are both effective and associated with fewer adverse effects. Considering the continuous rise in the number of

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9

Kravchenko, T. V., O. I. Panasenko, and Ye G. Knysh. "Synthesis and physicochemical properties 4-((R))amino)-5-methyl-4H-1,2,4-triazole-3-thiols." Farmatsevtychnyi zhurnal, no. 6 (August 14, 2018): 55–59. http://dx.doi.org/10.32352/0367-3057.6.16.02.

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Purposeful synthesis of derivatives of 1,2,4-triazole is one of the most important branches of modern pharmaceutical science Modern pharmaceutical market of domestic medicines requires constant updates of existing range. It makes possible the synthesis of new compounds with a predicted biological activity. The main advantage of derivatives of 1,2,4-triazole is high efficiency and low toxic. That is promising factor for creation of new chemical compounds. Analysis of literary data of past few years has showed that there is not enough information about synthesis, physical, chem

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10

Pintea, Beniamin-Nicolae, Ion Burcă, Valentin Badea, and Francisc Peter. "Synthesis of a Novel 2-((4,5-Diphenyl-4H-1,2,4-triazol-3-yl)thio)acetaldehyde as a Bisulfite Adduct." Molbank 2023, no. 3 (2023): M1715. http://dx.doi.org/10.3390/m1715.

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The scope of the current work was to synthesize an S-alkylated 1,2,4-triazole-3-thiol derivative. Synthesis was carried out in two steps: in the first step, 4,5-diphenyl-4H-1,2,4-triazole-3-thiol was S-alkylated using a halogenated acetal and cesium carbonate. In the second step, several acetal deprotection procedures were tested, and the aldehyde obtained was isolated as a bisulfite adduct. The structures of the new compounds were characterized by FT-IR, 1D, and 2D NMR spectroscopic methods.

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11

Mahdi, Monther F., Noor H. Naser, and Nethal H. Hammud. "SYNTHESIS AND PRELIMINARY PHARMACOLOGICAL EVALUATION OF NEW NAPROXEN ANALOGUES HAVING 1, 2, 4-TRIAZOLE-3-THIOL." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 7 (2017): 66. http://dx.doi.org/10.22159/ijpps.2017v9i7.18273.

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Objective: The objective of this search was to synthesize a new naproxen analogues having a 1,2,4-triazole-3-thiol heterocyclic ring, and preliminary pharmacological assessment of the anti-inflammatory activity of the synthesized compounds. Methods: The synthesis of naproxen analogues that having 1,2,4-triazole-3-thiol heterocyclic ring occur through esterification of naproxen, and then its reaction with hydrazine hydrate, and carbon disulfide, finally different aromatic aldehydes reacted with triazole derivatives of naproxen containing amino group to produce schiff bases.Results: In vivo acut

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12

Holla, Bantwala S., Channamata S. Prasanna, Boja Poojary, Mithun Ashok, Kottapalli S. Rao, and Kanakamajalu Shridhara. "Synthesis, Characterization and Antibacterial Studies of Some 1,2,4-Triazole Derivatives Containing a 6-Chloropyridin-3-yl methyl Moiety." Zeitschrift für Naturforschung B 61, no. 3 (2006): 334–38. http://dx.doi.org/10.1515/znb-2006-0315.

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Abstract5-(6-Chloropyridin-3-yl methyl)-4-phenyl-1,2,4-triazole-3-thiol (2) and 5-substituted-4-phenyl- 1,2,4-triazole-3-thiols (3) were synthesized. Alkylation and aminomethylation reactions of these triazoles were also carried out. Some of the newly synthesized compounds were screened for their antibacterial activities.

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13

Journal, Baghdad Science. "Synthesis of Some New 1,2,4-Triazoles Derived from 2-Mercaptobenzimidazole." Baghdad Science Journal 6, no. 1 (2009): 200–208. http://dx.doi.org/10.21123/bsj.6.1.200-208.

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New 1,2,4-triazole derivatives of 2-mercaptobenzimidazole (MB) are reported. Ethyl (benzimidazole-2-yl thio) acetate (1) has been prepared by condensing 2-mercaptobenzimidazole with ethylchloroacetate. The ester (1) on reacting with hydrazine hydrate gave the corresponding acetohydrazide(2)which was reacted separately with phenylisocyanate and phenylisothiocyanate, followed by ring closure in an alkaline medium giving 3-[(benzimidazole-2-yl thio) methyl]-4-phenyl-1,2,4-triazole-5-ol and 3-[(benzimidazole-2-yl thio) methyl]-4-phenyl-1,2,4-triazole-5-thiol respectively (6,7). Reaction of acetohy

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14

Al-Messri, Zainab, A. K. "Synthesis of Some New 1,2,4-Triazoles Derived from 2-Mercaptobenzimidazole." Baghdad Science Journal 6, no. 1 (2009): 200–208. http://dx.doi.org/10.21123/bsj.2009.6.1.200-208.

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Анотація:

New 1,2,4-triazole derivatives of 2-mercaptobenzimidazole (MB) are reported. Ethyl (benzimidazole-2-yl thio) acetate (1) has been prepared by condensing 2-mercaptobenzimidazole with ethylchloroacetate. The ester (1) on reacting with hydrazine hydrate gave the corresponding acetohydrazide(2)which was reacted separately with phenylisocyanate and phenylisothiocyanate, followed by ring closure in an alkaline medium giving 3-[(benzimidazole-2-yl thio) methyl]-4-phenyl-1,2,4-triazole-5-ol and 3-[(benzimidazole-2-yl thio) methyl]-4-phenyl-1,2,4-triazole-5-thiol respectively (6,7). Reaction of acetohy

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15

Mekky, Athraa Hameed, Fadil M. Hamed, and Bassam A. Hassan. "Synthesis, Characterization, Molecular Docking Studies and Pharmaceutical Evaluation of some Novel [1,2,4]Triazolo[3,4-B][1,3,4]Thiadiazole." Jurnal Kimia Valensi 10, no. 2 (2024): 304–14. https://doi.org/10.15408/jkv.v10i2.40043.

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A new series of fused [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazole 4a-4e have been synthesized by many steps. Firstly, benzohydrazide [1] has been synthesized from the reaction of methyl benzoate with hydrazine hydrate. Secondly, the cyclization reaction of benzohydrazide with carbon disulfide in the presence of potassium hydroxide produced 5-phenyl-1,3,4-oxadiazole-2-thiol[2]. Thirdly,5-phenyl-1,3,4-oxadiazole-2-thiol[2] was treated with potassium hydroxide using pyridine to give 4-amino-5-phenyl-4H-1,2,4-triazole-3-thiol. Finally, the fused [1,2,4]Triazolo[3,4-B][1,3,4]Thiadiazole 4a-4e were syn

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16

Бігдан, О. А. "Antimicrobial and antifungal activity of new fluorophenyl-containing 1,2,4-triazoles." Farmatsevtychnyi zhurnal, no. 2 (April 22, 2021): 87–93. http://dx.doi.org/10.32352/0367-3057.2.21.09.

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The achievements of the world organic chemistry are most clearly represented by scientific publications that prove the promising nature of heterocyclic substances. The possibility of combining various pharmacophore fragments and 1,2,4-triazole in one molecule is quite popular. In 2018, the drug Trifuzol-NEO appeared on the veterinary market of Ukraine, which took its rightful place among synthetic immunomodulators for various groups of unproductive animals. So, further studies of new promising compounds among substituted 1,2,4-triazole, which can be used as objects for the creation of ne

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17

Zaher, Nashwa Hafez, Mohammed Ismail Mostafa, and Abdullah Yousef Altaher. "Design, synthesis and molecular docking of novel triazole derivatives as potential CoV helicase inhibitors." Acta Pharmaceutica 70, no. 2 (2020): 145–59. http://dx.doi.org/10.2478/acph-2020-0024.

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AbstractMiddle East respiratory syndrome coronavirus (MERS-CoV) had emerged and spread because of the worldwide travel and inefficient healthcare provided for the infected patients in several countries. Herein we investigated the anti-MERS-CoV activity of newly synthesized sixteen halogenated triazole compounds through the inhibition of helicase activity using the FRET assay. All new compounds underwent justification for their target structures via microanalytical and spectral data. SAR studies were performed. Biological results revealed that the most potent compounds were 4-(cyclopent-1-en-3-

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18

Safonov, A. A., Т. V. Panasenko, E. G. Knysh, and N. M. Polishchuk. "Antimicrobial and antifungal properties of 4-((R-iden)amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol." Farmatsevtychnyi zhurnal, no. 2 (February 12, 2019): 96–99. http://dx.doi.org/10.32352/0367-3057.2.15.02.

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For creating a new biologically active compounds are using a system on which already exist medications. One such system is the core of 1,2,4-triazole. The aim of our work was to study the antimicrobial and antifungal activity new 4-((R-iden)amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiols. The study was conducted according to the method of serial dilutions. As a result of studies new synthesized 4-((R-idene)amino)-5-(thiophene-2-ilmetyl)-4H-1,2,4-triazoles-3-thiols exhibit antimicrobial and antifungal activity. The most active compound that exhibits antimicrobial act

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19

Sabzi, Noor Ali Hussein, and May Mohammed Jawad Al-Mudhafar. "Synthesis, characterization, and antimicrobial evaluation of new Schiff bases derived from vanillic acid conjugated to heterocyclic 4H-1,2,4-triazole-3-thiol." Pharmacia 70, no. 3 (2023): 657–63. http://dx.doi.org/10.3897/pharmacia.70.e104579.

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Анотація:

A multistep synthesis was established for the preparation of a new vanillic acid-1, 2, 4-1triazole-3-thiol conjugate (4). Finally, several aromatized aldehydes reacted with compound (4) to produce Schiff bases derivatives (5–11). The purpose of this research is to prepare new vanillic acid derivatives with 1, 2, 4-triazole-3-thiol heterocyclic ring structures and to evaluate their antimicrobial activity in a preliminary assessment. Fourier-transform infrared (FT-IR) and proton nuclear magnetic resonance spectroscopy (1H-NMR) were used to verify the structures of the newly synthesized compounds

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20

Kumar, Abhay, Vivek Kumar, Piyush Kumar, Pooja Kumari Yadav, and L. K. Mishra. "Synthesis and Characterization of Novel Mn(II), Fe(II) and Fe(III) complex of 5-ethyl-4-[(E)- (phenylmethylidene) amino]-4H-1,2,4-triazole-3-thiol." International Journal for Research in Applied Science and Engineering Technology 11, no. 9 (2023): 1585–90. http://dx.doi.org/10.22214/ijraset.2023.55892.

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Abstract: The synthesis and characterization of metal complexes with Triazole Schiff Base ligand is of great utility as these compounds possesses a wide variety of biological and medicinal properties. 1,2,4-triazole Schiff base ligand, 5-ethyl-4-[(E)- (phenylmethylidene) amino]-4H-1,2,4-triazole-3-thiol and its metal complexes with Mn(II), Fe(II) and Fe(III) were prepared. The ligand was characterized by micro analytical technique and FT-IR, 1H & 13C NMR spectroscopy. The IR spectra of the metal complex revealed that ligand is bidentate and donating to metal ion from deprotonated thiol gro

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21

Fedotov, S. O., and A. S. Hotsulia. "Synthesis and properties of S-alkyl 4-amino-5-(5-(3-fluorophenyl)-pyrazol-3-yl)-1,2,4-triazole-3-thiol derivatives." Current issues in pharmacy and medicine: science and practice 16, no. 1 (2023): 5–11. http://dx.doi.org/10.14739/2409-2932.2023.1.273461.

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Анотація:

An important direction of modern pharmaceutical science is the creation of promising biologically active compounds, which in the hands of scientists can be transformed into effective medicinal products. Heterocyclic compounds are the undisputed leader in solving this problem. A well-known fact and a well-founded approach to achieving the desired pharmacological effect is the combination of different heterocyclic fragments in the structure of one molecule. And here it makes sense to focus our attention on such heterocycles as pyrazole and 1,2,4-triazole. After all, a number of well-known medici

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22

Fedotov, S. O., and A. S. Hotsulia. "Synthesis and properties of S-derivatives of 4-amino-5-(5-methylpyrazol-3-yl)-1,2,4-triazole-3-thiol." Current issues in pharmacy and medicine: science and practice 14, no. 3 (2021): 268–74. http://dx.doi.org/10.14739/2409-2932.2021.3.243176.

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Анотація:

The combination of various heterocyclic systems with a wide range of properties is quite expedient and is, in practice, a justified direction for obtaining biologically active substances, which ultimately forms a favorable basis for the creation of drugs. In recent decades, the attention of scientists has been closely focused on nitrogen-containing heterocyclic compounds. Among such compounds, 1,2,4-triazole and pyrazole occupy a special place. Indeed, on the basis of these systems, a significant number of well-known drugs have been created, which are widely used at the present time. The aim o

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23

Sabzi, Noor Ali Hussein, and May Mohammed Jawad Al-Mudhafar. "Synthesis, characterization, and antimicrobial evaluation of new Schiff bases derived from vanillic acid conjugated to heterocyclic 4H-1,2,4-triazole-3-thiol." Pharmacia 70, no. (3) (2023): 657–63. https://doi.org/10.3897/pharmacia.70.e104579.

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Анотація:

A multistep synthesis was established for the preparation of a new vanillic acid-1, 2, 4-1triazole-3-thiol conjugate (4). Finally, several aromatized aldehydes reacted with compound (4) to produce Schiff bases derivatives (5–11). The purpose of this research is to prepare new vanillic acid derivatives with 1, 2, 4-triazole-3-thiol heterocyclic ring structures and to evaluate their antimicrobial activity in a preliminary assessment. Fourier-transform infrared (FT-IR) and proton nuclear magnetic resonance spectroscopy (<sup>1</sup>H-NMR) were used to verify the structures of the newly synthesize

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24

Amit, Chattree* and Neelottma Singh. "In-Silico Designing of 5-(3 Chloro-1-Benzothien-2yl)-4-Phenyl-4H-1,2,4 Triazole-3-Thiol derivatives and their Potential application on Fusarium Solani." Journal of Pharma Research 1, no. 2 (2012): 7–10. https://doi.org/10.5281/zenodo.1098653.

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<strong><em>ABSTRACT</em></strong> <em>In silico methods can help in identifying drug targets via bioinformatics tools. The use of computers and computational methods permeates all aspects of drug discovery and forms the core of structure-based drug design. High-performance computing, data management software and internet are facilitating the access of huge amount of data generated and transforming the massive complex biological data into workable knowledge in modern day drug discovery process. In the present work insilico designing of 5-(3 Chloro-1-benzothien-2yl)-4-phenyl-4H-1,2,4 triazole-3

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25

GOTSULYA, Andrey, Serhii FEDOTOV, Olena ZINYCH, Tetiana TROFIMOVA, and Tetiana BRYTANOVA. "S-ALKİL 4-(4-KLOROFENİL)-5-(PİROL-2-İL)-1,2,4-TRİAZOL-3-TİYOL TÜREVLERİNİN SENTEZİ VE ÖZELLİKLERİ." Ankara Universitesi Eczacilik Fakultesi Dergisi 47, no. 3 (2023): 32. http://dx.doi.org/10.33483/jfpau.1280492.

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Анотація:

Objective: The aim of the work was to develop effective methods for the synthesis of promising heterocyclic systems based on pyrrole and 1,2,4-triazole. In the process of realizing of this aim, 10 new S-alkyl 4-(4-chlorophenyl)-5-(pyrrole-2-yl)-1,2,4-triazole-3-thiol derivatives were synthesized. Material and Method: Chemical structures of synthesized compounds were characterized with elemental analysis, 1H-NMR, LC-MS techniques. The biological potential of the synthesized substances was estimated by the molecular docking method and ADME analysis. Result and Discussion: An optimum method for t

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26

Safonov, A. A., and O. I. Panasenko. "Synthesis, antimicrobial and antifungal activity of 3-(2-bromophenyl)-5-(alkylthio)-4-phenyl-4H-1,2,4-triazoles." Current issues in pharmacy and medicine: science and practice 15, no. 3 (2022): 235–40. http://dx.doi.org/10.14739/2409-2932.2022.3.264691.

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To select a molecule that could become a promising pharmacological agent, chemists use already-known heterocyclic bases by adding pharmacologically active groups. One such heterocyclic system is 1,2,4-triazole base, on the basis of which a huge number of biologically active compounds have already been found. It is known that 1,2,4-triazole derivatives show a fairly high antimicrobial and antifungal effect while remaining low-toxic compounds and 5-alkylthio-1,2,4-triazoles exhibit antimicrobial and antifungal activity. Based on the literature search, it can be concluded that 3-(2-bromophenyl)-5

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Wadher, S. J., T. M. Kalyankar, M. P. Puranik, S. B. Jangam, and P. G. Yeole. "SYNTHESIS, SPECTRAL STUDIES AND ANTIANXIETY ACTIVITY OF SOME SCHIFF BASES OF 4-(AMINO)-5-PHENYL-4H-1,2,4-TRIAZOLE-3-THIOLS." INDIAN DRUGS 52, no. 12 (2015): 56–59. http://dx.doi.org/10.53879/id.52.12.10294.

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Анотація:

A series of 4-(4-substituted benzylideneamino)-5-phenyl-4H-1,2,4-triazole-3-thiols (IVa-e) was obtained by reaction of 4-(amino)-5-phenyl-4H-1,2,4-triazole-3-thiol with aromatic aldehyde in presence of concentrated sulphuric acid. The synthesised compounds were characterized by FT-IR, 1H-NMR and mass spectra data. The compounds (IVa-e) were screened for their antianxiety activity. Among the compounds, IVa and IVe were found to be the most acitive antianxiety compounds.

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Martynyshyn, V. P., V. M. Hunchak, B. V. Gutyj, and O. P. Rudenko. "Prediction of biological activity of 4-(3,4 dimethoxybenzylidene)amino)-5-(2-fluorophenyl)-4H-1,2,4 triazole-3-thiol." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 26, no. 116 (2024): 255–59. https://doi.org/10.32718/nvlvet11637.

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Анотація:

Among the various heterocyclic systems, 1,2,4-triazole derivatives occupy a leading position due to a whole range of unique and valuable properties. 1,2,4-triazole derivatives exhibit a wide range of pharmacological activity, affecting various biochemical processes while having minimal toxicity. Due to their unique chemical structure, these heterocyclic compounds exhibit different biological properties, making them promising for developing new drugs. The work aimed to study new types of activity of 4-(3,4-dimethoxybenzylidene)amino)-5-(2-fluorophenyl)-4Н-1,2,4-triazole-3-thiol using in silico

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29

Shcherbyna, R. О., O. I. Panasenko, Ye H. Knysh, and O. M. Kamyshnyy. "The studing of antimicrobial activity of 4-(R-ylidenamino)-3-( morpholinomethylene)-4H-1,2,4-triazole-5-thiol." Farmatsevtychnyi zhurnal, no. 4 (September 4, 2018): 92–95. http://dx.doi.org/10.32352/0367-3057.4.15.04.

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Анотація:

According to the information of the World Health Organization (WHO) the lethal cases caused by pathogenic microorganisms occupied the one of the leading places. Most acutely the problem posed in countries where economic opportunities does not hold the flashes of infectious diseases under control. Therefore necessity of the new, available and high bactericidal drugs is reasonable and justified. Unfortunately, in literary sources missing information which devoted to 4-(R-ylidenamino)-3-(morpholinomethylene)-4H-1,2,4-triazole-5-thioles. The main aim of our work are studying antimicrobial an

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Bihdan, O. A., and V. V. Parchenko. "Synthesis and physical-chemical properties of some 5-(3-fluorophenyl)-4-methyl-1,2,4-triazole-3-thiol derivatives." Farmatsevtychnyi zhurnal, no. 2 (August 14, 2018): 38–47. http://dx.doi.org/10.32352/0367-3057.2.17.05.

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Анотація:

There are engaged scientists practically from all over the world to the 1,2,4-triazole system research but the greatest attention deserve the achievements of domestic scientists who managed from the very beginning to register new original medicines in Ukraine. There is no doubt that the original attempt of combining various typical fragments with the nucleus of 1,2,4-triazole is gaining popularity among researchers. The purpose of our work was to synthesized and investigate a row of new 5-(3-fluorophenyl)-4-methyl-1,2,4-triazole-3-thiols by a Sulfur atom, to study the physical-chemical p

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31

Panasenko, O. I., V. M. Odyntsova, and A. S. Hotsulia. "In silico evaluation of the pharmacodynamic component of the interaction of S-alkyl derivatives of 5-methyl-4-(p-tolyl)-1,2,4-triazole-3-thiol with some biological targets." Current issues in pharmacy and medicine: science and practice 16, no. 3 (2023): 223–30. http://dx.doi.org/10.14739/2409-2932.2023.3.287510.

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Анотація:

Derivatives of 1,2,4-triazole open wide opportunities for modern and progressive scientists in the development of innovative medicines. These compounds are known for their variability and structural flexibility, which allows scientists to experiment and create new molecules with unique properties. The use of 1,2,4-triazole derivatives in the creation of drugs is based on their ability to interact with biological systems and molecular targets. These compounds can be aimed at regulating physiological processes, reducing manifestations of pathological conditions or enhancing necessary biological

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Mosleh, Ali Abdulhadi, and Zainab A. Dakhel. "Molecular docking, microwave-assisted synthesis, characterization, and preliminary evaluation of the anti-microbial activity of new sulfonamide derivatives of the 1, 2, 4-triazole-3-thiol ring system." Pharmacia 71 (September 3, 2024): 1–9. http://dx.doi.org/10.3897/pharmacia.71.e132720.

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Анотація:

A new sulfonamide derivative containing a 1,2,4-Triazole-3-thiol ring was synthesized and characterized using FT-IR and 1H-NMR. The microwave-assisted chemical synthesis of the 1,2,4-Triazole-3-thiol ring system resulted in good yield and purity. The synthetic compounds were then subjected to in vitro evaluation for antimicrobial study. All synthetic compounds show high activity against Gram-positive bacteria (S. aureus, S. pneumonia, and B. subtilis) and high activity against Gram-negative bacteria (P. aeruginosa, and H. pylori), with less activity against (N. gonorrhoeae, and E. coli). Also,

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Mustafa Taha Abdull, Monther F. Mahdi, and Ayad k. Khan. "Molecular docking, Synthesis and Characterization of New Indomethacin and Mefenamic Acid Analogues as Potential Anti-inflammatory Agents." Al Mustansiriyah Journal of Pharmaceutical Sciences 23, no. 3 (2023): 336–44. http://dx.doi.org/10.32947/ajps.v23i3.1052.

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Анотація:

In this work the pharmacological study and synthesis of new thiadiazine bearing on triazole which obtained from hippuric acid , indomethacin and mefenamic acid that have carboxylic acid moiety, Drugs with carboxylic groups and thiocarbohydrazide interacted to produce the 4-amino-5-aryl-4H-1,2,4-triazole-3-thiol (1a-c). and the starting products 4-amino-5-aryl-4H-1,2,4-triazole-3-thiol) were treated with chloroacetyl chloride to produce final products (2a-c). To confirm the structure of the generated compounds, FT-IR, 1H-NMR, and mass spectroscopy were used to characterize all derivatives

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34

Mosleh, Ali Abdulhadi, and Zainab A. Dakhel. "Molecular docking, microwave-assisted synthesis, characterization, and preliminary evaluation of the anti-microbial activity of new sulfonamide derivatives of the 1, 2, 4-triazole-3-thiol ring system." Pharmacia 71 (September 3, 2024): 1–9. https://doi.org/10.3897/pharmacia.71.e132720.

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Анотація:

A new sulfonamide derivative containing a 1,2,4-Triazole-3-thiol ring was synthesized and characterized using FT-IR and 1H-NMR. The microwave-assisted chemical synthesis of the 1,2,4-Triazole-3-thiol ring system resulted in good yield and purity. The synthetic compounds were then subjected to in vitro evaluation for antimicrobial study. All synthetic compounds show high activity against Gram-positive bacteria (<i>S. aureus</i>, <i>S. pneumonia</i>, and <i>B. subtilis</i>) and high activity against Gram-negative bacteria (<i>P. aeruginosa</i>, and <i>H. pylori</i>), with less activity against (

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35

Vekariya, Piyush B., Jalpa R. Pandya, and Hitendra S. Joshi. "An Efficient and Facile Synthesis of 1,2,4-Aryl Triazoles and 4-Thiazolidinones Bearing 6-Fluorochroman Nucleus." International Scholarly Research Notices 2014 (October 30, 2014): 1–7. http://dx.doi.org/10.1155/2014/186207.

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Анотація:

A new generation of chroman bearing heterocyclic five membered ring such as 1,2,4-triazoles and thiazolidinones was designed and synthesized. New chroman based nucleus 5-(6-fluorochroman-2-yl)-4-aryl-4H-1,2,4-triazole-3-thiol and 6-fluorochroman-N-(4-oxo-2-arylthiazolidinin-3-yl) chroman-2-carboxamides were synthesized. Aryl triazole compounds 4a–4j were synthesized from 6-fluorochroman-2-carbohydrazide 2 on reaction with base in methanol and CS2 followed by reaction with substituted aniline. Thiazolidinone compounds 5a–5j were synthesized from 6-fluorochroman-2-carbohydrazide 2 on reaction wi

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36

GABRYSZEWSKI, M. "ChemInform Abstract: Silver(I) Complexes of 1H-1,2,4-Triazole-3-thiol, 3-Amino-5-mercapto-1, 2,4-triazole, and 3-Amino-5-methylthio-1,2,4-triazole." ChemInform 27, no. 50 (2010): no. http://dx.doi.org/10.1002/chin.199650190.

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37

Biswa, Mohan Sahoo, Nagamounika K., and Krishna Banik Bimal. "Microwave-assisted synthesis of Schiff's bases of 1,2,4-triazole derivatives and their anthelmintic activity." Journal of Indian Chemical Society Vol. 95, Nov 2018 (2018): 1289–94. https://doi.org/10.5281/zenodo.5652476.

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Department of Pharmacy, Vikas Group of Institutions, Nunna, Krishna District, Vijayawada-521 229, Andhra Pradesh, India E-mail: drbiswamohansahoo@gmail.com Community Health System of South Texas, Edinburg, Texas 78539, USA E-mail: bimalbanik10@gmail.com <em>Manuscript received on line 26 September 2018, accepted 01 November 2018</em> Schiff’s bases of 1,2,4-triazole-3-thiol are synthesized by multistep reactions. Schiff bases are the condensation products of primary amines with carbonyl compounds. These compounds possess imine or azomethine (-C=N-) functional group in their structure and

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38

Mroczek, Tomasz, Tomasz Plech, and Monika Wujec. "Novel Concept of Discrimination of 1,2,4-Triazole-3-thione and 3-Thiol Tautomers." Journal of Chromatographic Science 55, no. 2 (2016): 117–29. http://dx.doi.org/10.1093/chromsci/bmw151.

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39

Afrough, T., M. Bakavoli, and H. Eshghi. "Synthesis and characterisation of new 3-methyl-6-[1-(pyrimidin-4-yl)ethyl]-5H-pyrimido[5,4-e][1,2,4]triazolo[3,4-b][1,3,4]thiadiazine derivatives." Journal of Chemical Research 41, no. 7 (2017): 376–79. http://dx.doi.org/10.3184/174751917x14967701766978.

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Анотація:

A new series of 3-methyl-6-[1-(pyrimidin-4-yl)ethyl]-5 H-pyrimido[5,4- e][1,2,4]triazolo[3,4- b][1,3,4]thiadiazine derivatives was synthesised through the condensation reaction of 5-bromo-4-[1-(5-bromo-2,6-dichloropyrimidin-4-yl)ethyl]-2-chloro-6-methylpyrimidine and 4-amino-5-methyl-4 H-1,2,4-triazole-3-thiol.

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40

Karpenko, Yu V., O. I. Panasenko, and A. P. Litun. "Search for molecular descriptors and computer prediction of biological activity in a series of S-derivatives (1,2,4-triazole-3(2H)-yl)methyl)thiopyrimidines." Current issues in pharmacy and medicine: science and practice 17, no. 1 (2024): 5–9. http://dx.doi.org/10.14739/2409-2932.2024.1.298027.

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Анотація:

Most pharmaceutical compounds interact with various molecular compositions in the body, leading to complex biological effects. Furthermore, during biotransformation, they may generate one or more metabolites with potent bioactive properties. Therefore, the development and careful use of new medications require thorough examination of their biological impact profiles, including considerations of human metabolic processes. In silico techniques are currently widely used to evaluate the interactions of emerging drug candidates with pharmacological conditions and predict their metabolic conversions

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Murat Farsak. "An Acid Inhibitor Research: 5-Phenyl-1H-1,2,4-triazole-3-thiol." Protection of Metals and Physical Chemistry of Surfaces 55, no. 3 (2019): 566–71. http://dx.doi.org/10.1134/s2070205119030122.

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Хільковець, А. В. "Some transformations and physicochemical properties of new S-substituted 5-thiophene-(3-ylmethyl)-4R-1,2,4-triazole-3-thiols." Farmatsevtychnyi zhurnal, no. 5 (October 22, 2021): 50–56. http://dx.doi.org/10.32352/0367-3057.5.21.05.

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Анотація:

Nitrogen-containing heterocyclic compounds are widely represented in modern organic chemistry. A special place among the huge number of substances presented is occupied by derivatives of 1,2,4-triazole due to their uniqueness and prospects. In recent years, these derivatives have remained the object of close attention of both synthetic chemists and researchers engaged in the search for new biologically active substances of a wide spectrum of action, the synthesis of optical materials, dyes, corrosion inhibitors, veterinary drugs, etc. It is known from the literature that the combination of the

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43

Ohloblina, M. V., I. V. Bushuieva, and V. V. Parchenko. "The results of determining the indicators of the morphological composition of the blood of animals and individual biochemical indicators using a potential drug with a mixture of two active compounds: 4-((5-(decylthio)-4-methyl-4H-1,2,4-triazole-3-yl)methyl)morpholine and 5-(2-fluorophenyl)-4-((4-bromophenyl)ylidene)amino-1,2,4-triazole-3-thiol in milk thistle seed oil." Current issues in pharmacy and medicine: science and practice 15, no. 3 (2022): 283–87. http://dx.doi.org/10.14739/2409-2932.2022.3.263015.

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The introduction of new domestic highly effective and safe medicines into medical and veterinary practice is an important task of modern pharmaceutical science. Continuation of the search and conduct of research to bring the biological activity of 1,2,4-triazole derivatives is one of the promising areas of such activity. At this stage of research, it is known that such 1,2,4-triazole derivatives as 4-((5-(decylthio)-4-methyl-4H-1,2,4-triazole-3-yl)methyl)morpholine and 5-(2-fluorophenyl)-4-((4-bromophenyl)ylidene)amino-1,2,4-triazole-3-thiol have a wide spectrum of biological activity. Interes

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Panda, Krishna Chandra, B. V. V. Ravi Kumar, and Biswa Mohan Sahoo. "Synthesis of Schiff’s Bases of 1,2,4-Triazole Derivatives under Microwave Irradiation Technique and Evaluation of their Anti-diabetic Activity." Current Microwave Chemistry 8, no. 3 (2021): 215–24. http://dx.doi.org/10.2174/2213335608666210930201144.

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Background: Schiff bases play a key role in the generation of a large number of biologically active compounds via cycloaddition, replacement, and ring closure reactions. Objective: The objective of this study is to optimize the purity and yield of the product, improve the reaction time, and make the reaction more eco-friendly with the help of microwave-assisted organic synthesis. Methods: New series of Schiff’s bases of triazole derivatives were achieved via multicomponent reactions. The starting material benzohydrazide 1 was obtained by esterification of benzoyl chloride with methanol in the

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45

Bui, Thanh-Tu, Hoang-Uy Tan, Hoang-Danh Nguyen, and Tan-Tai Nguyen. "Synthesis of new triazole-fused bicyclic heterocycles involving benzofuran from 4-amino-1,2,4-triazole-3-thiol." Tạp chí Khoa học - Trường Đại học Sư phạm Hà Nội 2 1, no. 2 (2023): 64–69. http://dx.doi.org/10.56764/hpu2.jos.2023.1.2.64-69.

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Анотація:

In the further research and synthesis of hybrid molecules which exhibit highly biological activities, the synthesis of triazole-fused bicyclic heterocycles bearing the benzofuran has been undertaken. A facile, convenient and good yielding synthesis of novel benzofuran-bearing 1,2,4-trazole derivatives were described. Herein, two derivatives of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole were synthesized from salicylaldehyde in four steps in moderate to good yields. Structures of all the targeted synthesized compounds were elucidated by spectral methods of analysis

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Koparır, M., A. Çetin, and A. Cansız. "5-Furan-2yl[1,3,4]oxadiazole-2-thiol, 5-Furan-2yl-4H [1,2,4] triazole-3-thiol and Their Thiol-Thione Tautomerism." Molecules 10, no. 2 (2005): 475–80. http://dx.doi.org/10.3390/10020475.

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Kumari, V. Anitha, Shaheen Begum, and K. Bharathi. "in silico Evaluation of 4-Amino-5-substituted-4H-1,2,4-triazole-3-thiol Derivatives against DNA Gyrase, COX-2 and Cathepsin B." Asian Journal of Chemistry 31, no. 8 (2019): 1748–54. http://dx.doi.org/10.14233/ajchem.2019.21956.

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Анотація:

Biological activities of 1,2,4-triazoles, in particular, anticancer, anti-inflammatory and antimicrobial activities are potentiated by the presence of thiol group and free amino groups. Enticed by this, a series of 1,2,4-triazole derivatives were designed by introducing different substituent groups at 5th position of 4-amino-4H-1,2,4-triazole-3-thiol ring and their binding affinities were determined by molecular docking studies with the targets associated with bacterial infections, inflammation and cancer (DNA gyrase, cyclooxygenase-II (COX-2) and cathepsin B; PBD IDs: 1KZN, 3LN1 and 1SP4). Re

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Martynyshyn, V. P., and V. M. Semtsov. "Study of the acute toxicity of 4-(3,4-dimethoxybenzylidene)amino)-5-(2-fluorophenyl)-4H-1,2,4-triazole-3-thiol by in silico and in vivo methods." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 26, no. 114 (2024): 198–202. http://dx.doi.org/10.32718/nvlvet11429.

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Анотація:

The process of creating new medicines includes many stages that make it possible to use them in veterinary practice in the future. These tests guarantee the effectiveness and safety of newly synthesized compounds. One of the most critical stages of preclinical studies is the establishment of acute toxicity. Thus, the results of this experiment indicate the possible presence of a toxic effect in new compounds, which affects the practicality of their future use. Among the various heterocyclic systems, 1,2,4-triazole derivatives occupy a leading place due to the whole spectrum of unique and preci

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Hammud, Hassan H., Moheddine Wehbie, Mohamed M. Abdul-Ghani, Zoltan A. Gal, Malai Haniti Sheikh Abdul Sheikh Abdul Hamid, and Nadeem S. Sheikh. "Synthesis, DFT and X-ray Studies of Trans CuCl2L2 with L Is (E)-(4-chlorophenyl)-N-(3-phenyl-4H-1,2,4-triazol-4-yl)methanimine." Inorganics 11, no. 1 (2022): 18. http://dx.doi.org/10.3390/inorganics11010018.

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Анотація:

A novel approach was carried to prepare trans-CuCl2L2 complex with the ligand L, (E)-(4-chlorophenyl)-N-(3-phenyl-4H-1,2,4-triazol-4-yl)methanimine which was formed in situ during the reaction of CuCl2 with 4-(4-chlorobenzylideneamino)-5-phenyl-2H-1,2,4-triazole-3(4H)-thione. The synthesized compounds were characterized by applying various spectroscopic techniques. The crystal structure of the complex was unambiguously determined using X-ray analysis indicating square planar geometry. Intermolecular H-bonds govern the supramolecular structure of the copper complex. Aromatic rings are stacked i

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Karpun, Yevhen, Volodymyr Parchenko, Tetiana Fotina, et al. "The investigation of antimicrobial activity of some s-substituted bis-1,2,4-triazole-3-thiones." Pharmacia 68, no. 4 (2021): 797–804. http://dx.doi.org/10.3897/pharmacia.68.e65761.

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Анотація:

New S-substituted 4-alkyl-5-((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1,2,4-triazole-3-thiol derivatives have been designed, synthesized and studied their antimicrobial activity on 11 standard Gram-positive and Gram-negative microorganism strains. Their spectral and physicochemical parameters were established using modern comprehensive methods of analysis, including 1H NMR spectroscopy, GC-MS and elemental analysis.It has been found that compound 2a exhibits strong suppression of 5 test strains (MBC = 15.6 µg/mL). Compound 4a showed moderate inhibition of Salmonella pullorum, E

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