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Статті в журналах з теми "Upper Canada Committee"

Автор: Grafiati

Опубліковано: 25 липня 2024

Оновлено: 31 липня 2025

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1

Deane, Adam M., Waleed Alhazzani, Gordon Guyatt, et al. "REVISE:Re-Evaluating theInhibition ofStressErosions in the ICU: a randomised trial protocol." BMJ Open 13, no. 11 (2023): e075588. http://dx.doi.org/10.1136/bmjopen-2023-075588.

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IntroductionTheRe-Evaluating theInhibition ofStressErosions (REVISE) Trial aims to determine the impact of the proton pump inhibitor pantoprazole compared with placebo on clinically important upper gastrointestinal (GI) bleeding in the intensive care unit (ICU), 90-day mortality and other endpoints in critically ill adults. The objective of this report is to describe the rationale, methodology, ethics and management of REVISE.Methods and analysisREVISE is an international, randomised, concealed, stratified, blinded parallel-group individual patient trial being conducted in ICUs in Canada, Aust

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2

Di Mascio, Anthony. "Educational Discourse and the Making of Educational Legislation in Early Upper Canada." History of Education Quarterly 50, no. 1 (2010): 34–54. http://dx.doi.org/10.1111/j.1748-5959.2009.00244.x.

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In 1787, a group of American refugee settlers in the western portion of Quebec, which would become the colony of Upper Canada in 1791, collectively petitioned the Governor General, Lord Dorchester, for schools. They insisted, in fact, on a relatively comprehensive network of schools funded directly through the government purse. Dorchester responded by appointing William Smith, the former Chief Justice of New York State with whom he had formed a political friendship during the American War of Independence, to head a special committee to report on the state of education throughout the entire pro

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3

McHugh, James T. "Canadian Senate Reform: Lessons from Its First Decade, 1867–78." International Journal of Canadian Studies 62 (July 1, 2024): 181–209. http://dx.doi.org/10.3138/ijcs-2023-0010.

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During the 19th century and through the 20th century, the role of the parliamentary upper house (especially, but not exclusively, within the Westminster system of government) changed in subtle, yet dramatic, ways. Among those changes was increasing deference to elected lower houses of parliament, a reduction in partisanship in its actions and legislative goals, the development and pursuit of greater specialization of interest and function, appeals to the public interest beyond the electoral mandate, and greater practical attention to technical overview and improvement of legislation and policy

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4

Carson, Chris J., Robert G. Berman, Richard A. Stern, Mary Sanborn-Barrie, Tom Skulski, and Hamish AI Sandeman. "Age constraints on the Paleoproterozoic tectonometamorphic history of the Committee Bay region, western Churchill Province, Canada: evidence from zircon and in situ monazite SHRIMP geochronology." Canadian Journal of Earth Sciences 41, no. 9 (2004): 1049–76. http://dx.doi.org/10.1139/e04-054.

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In situ UPb sensitive high-resolution ion microprobe (SHRIMP) analyses of monazite from upper amphibolite-facies paragneiss of the Committee Bay supracrustal belt, central Rae domain, Canada, reveal three age populations: ca. 2350, 1850, and 1780 Ma. The ca. 1850 Ma age also corresponds to growth of low Th/U zircon as indicated by UPb SHRIMP analyses of zircon separates from melanosome and leucosome. The contextual advantage of the in situ monazite analysis allows evaluation of the geochronological data in terms of the regional structural and metamorphic evolution. The region is dominated by

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5

McKinnell, S., and J. R. Christian. "Seasonal pH and aragonite saturation horizons in the Gulf of Alaska during the North Pacific Survey, 1956–1957." Biogeosciences Discussions 6, no. 3 (2009): 4587–602. http://dx.doi.org/10.5194/bgd-6-4587-2009.

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Abstract. The extent of global change in carbon system parameters can only be evaluated by comparing present with past measurements. In the northern North Pacific, where aragonite saturation horizons are among the shallowest in the world, historical measurements of carbonate parameters vary from rare to nonexistent. However, during the summer of 1956 and winter of 1957, an extensive survey of the oceanography of the Northeast Pacific, under the auspices of the Canadian Committee on Oceanography, was conducted by the Fisheries Research Board of Canada. Approximately 2500 measurements of pH at d

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6

Trudeau, Pierre Elliot. "Le défi." La réforme des relations fédérales-provinciales 26, no. 1 (2005): 15–27. http://dx.doi.org/10.7202/042643ar.

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This speech was given by the Prime Minister at the closing banquet of the Conference on the Reform of Federal Institutions in Quebec on March 30, 1984. He suggested that Reform is desirable because Canadian Federalism is capable of evolution and renewal. Canada needs institutions in which a national consensus on its fundamental options can be developed frankly and openly. The federal government's representativeness and its authority to speak and act in the name of all regions and of all Canadians must be strengthened. The proposed reform of the Upper House conducted by the Special joint Commit

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7

Morris, Aaron, Evan Walters, Bassel Akache, Michael McCluskie, and Arthur Krieg. "604 Intravenous CMP-001, a CpG-A Toll-like receptor 9 (TLR9) agonist delivered via a virus-like particle, causes tumor regression in syngeneic Hepa1–6 mouse models of hepatocellular carcinoma." Journal for ImmunoTherapy of Cancer 8, Suppl 3 (2020): A639. http://dx.doi.org/10.1136/jitc-2020-sitc2020.0604.

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BackgroundTherapeutic options are limited for patients with liver metastases and hepatocellular carcinoma (HCC). Intratumoral and subcutaneous injections of CMP-001, a CpG-A TLR9 agonist packaged within a virus-like particle, have shown evidence of antitumor activity in patients with melanoma refractory to PD-1 blockade. In mice, CMP-001 intravenous distributes primarily to the liver, while CMP-001 subcutaneous is found mostly in local tissues and draining lymph nodes. The antitumor activity of CMP-001 intravenous and subcutaneous were compared with PD-1 blockade or sorafenib in two Hepa1-6 or

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8

JPT staff, _. "SPE Board Announces Nominees for 2024 President and 2023 Directors." Journal of Petroleum Technology 74, no. 07 (2022): 39–42. http://dx.doi.org/10.2118/0722-0039-jpt.

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2024 SPE President Terry Palisch is the vice president of technology and engineering at CARBO Ceramics in Richardson, Texas. He began his career with ARCO, during which he served 4 years in Algeria and 10 years as a senior petroleum engineer in Alaska. Palisch joined CARBO in 2004 and in his current position leads a team of technologists developing and championing new products and services and advising clients on completion and fracture optimization. Palisch has been an active SPE member serving in various roles, including past chairman of the SPE Dallas Section, past chair of the SPE Annual T

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9

Scanlon, James V., Benjamin P. Exter, Michael Steinberg, and Courtney I. Jarvis. "Ustekinumab: Treatment of Adult Moderate-to-Severe Chronic Plaque Psoriasis." Annals of Pharmacotherapy 43, no. 9 (2009): 1456–65. http://dx.doi.org/10.1345/aph.1m151.

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Objective: To systematically review the pharmacology, pharmacokinetics, clinical efficacy, and safety profile of ustekinumab to inform pharmacists and other healthcare professionals of this new biologic therapy for psoriasis. Data Sources: A search of PubMed/MEDLINE, EMBASE, and International Pharmaceutical Abstracts was performed through July 2009, limited to publications in English, using the search terms CNTO-1275, ustekinumab, interleukin-12, interleukin-23, and/or psoriasis to identify literature sources. References from the retrieved articles were also evaluated to identify relevant lite

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10

Capra, Marcelo, Thomas Martin, Philippe Moreau, et al. "Isatuximab Plus Carfilzomib and Dexamethasone Versus Carfilzomib and Dexamethasone in Relapsed Multiple Myeloma Patients with Renal Impairment: Ikema Subgroup Analysis." Blood 136, Supplement 1 (2020): 46–47. http://dx.doi.org/10.1182/blood-2020-136415.

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Introduction: Renal impairment (RI) is a common feature in multiple myeloma (MM) and an adverse predictor of survival. Anti-myeloma treatments that can also improve renal function in patients (pts) with MM are required. Isatuximab (Isa), a monoclonal CD38 antibody, is approved in combination with pomalidomide and dexamethasone (d), in the United States, the European Union, Canada, Australia, Switzerland, and Japan for the treatment of adult pts with relapsed/refractory MM who have received at least two prior therapies, including lenalidomide and a proteasome inhibitor. IKEMA (NCT03275285) was

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11

Apolo, Andrea B., Manish R. Patel, John Allan Ellerton, et al. "Avelumab treatment in metastatic urothelial carcinoma: Post-hoc analysis of high-risk populations in the phase Ib JAVELIN Solid Tumor Study." Journal of Clinical Oncology 37, no. 7_suppl (2019): 428. http://dx.doi.org/10.1200/jco.2019.37.7_suppl.428.

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428 Background: Avelumab is a human anti‒PD-L1 IgG1 antibody approved in the US, Canada, and Israel for the treatment of locally advanced or metastatic urothelial carcinoma (mUC) progressed after platinum chemotherapy. In the JAVELIN Solid Tumor study, patients (pts) in various subgroups had a favorable objective response rate (ORR) with avelumab. Here, we report further post hoc analyses of safety and efficacy outcomes with avelumab in high-risk mUC subgroups. Methods: Pts with mUC that had progressed after platinum-based therapy in the JAVELIN Solid Tumor study were analyzed. Best overall re

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12

Male, Christoph, Donald L. Yee, Christian Loewe, et al. "Comparison Of Ultrasound Versus Magnetic Resonance Venography For Diagnosis Of Catheter-Related Thrombosis In Children: A Multicenter Multinational Study." Blood 122, no. 21 (2013): 2377. http://dx.doi.org/10.1182/blood.v122.21.2377.2377.

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Abstract Background Venous thrombotic events (VTE) in children are related to central venous catheters and occur predominantly in the upper venous system. In routine clinical practice, ultrasound (US) is the most frequently used imaging technique for diagnosis of VTE in children because of its ease of use and non-invasiveness. However, US is known to be relatively insensitive for detection of VTE in the central upper venous system. Magnetic resonance venography (MRV) is a promising alternative as MRV can comprehensively image the central venous system, is minimally invasive and does not involv

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13

Sedarous, M., E. Lee, A. Verma, K. Quinn, and G. Hirschfield. "A114 IMPROVING THE QUALITY OF PARACENTESIS PRACTICES IN PEOPLE WITH ADVANCED CIRRHOSIS IN AN AMBULATORY CARE SETTING." Journal of the Canadian Association of Gastroenterology 7, Supplement_1 (2024): 85–86. http://dx.doi.org/10.1093/jcag/gwad061.114.

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Abstract Background Spontaneous bacterial peritonitis (SBP) is a lethal complication of decompensated cirrhosis carrying a 90% mortality rate when left untreated. Despite AASLD recommendations, there is a practice gap regarding fluid cell count (FCC) collection during paracentesis. Aims We initiated prospective quality improvement (QI) project to improve FCC collection in an ambulatory care setting from a baseline of 78% to a goal of 100% compliance between September 11, 2022 and April 17, 2023. Methods We examined the effects of a quality improvement initiative in 233 adult patient encounters

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14

Taibi, Amel, and Elena M. Comelli. "Practical approaches to probiotics use." Applied Physiology, Nutrition, and Metabolism 39, no. 8 (2014): 980–86. http://dx.doi.org/10.1139/apnm-2013-0490.

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Probiotics are microorganisms exerting beneficial effects on the host. They can be ingested through foods or supplements and their inclusion in these products is regulated in Canada by the Health Canada Health Products and Food Branch. The aim of this article is to summarize current evidence from randomized controlled trials and guidelines from Health Canada, the World Health Organization, and internationally recognized expert committees in the hope that it will help practitioners and professionals recommending probiotics to healthy and diseased patients, with a focus on the Canadian setting.

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15

Jain, Nitin, Elias J. Jabbour, Marina Konopleva, et al. "A Phase 1 Trial of Adct-602, a CD22 Targeting Antibody Drug Conjugate Bound to PBD Toxin in Adult Patients with Relapsed or Refractory CD22+ B-Cell Acute Lymphoblastic Leukemia." Blood 138, Supplement 1 (2021): 1237. http://dx.doi.org/10.1182/blood-2021-153141.

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Abstract Introduction: Outcomes of patients (pts) with relapsed or refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL) remain dismal, with 5-year survival &lt;20%. CD22 is expressed on lymphoblasts in &gt;90% of pts with B-ALL and is an established therapeutic target. ADCT-602 is an antibody drug conjugate composed of a humanized monoclonal antibody directed against CD22 and conjugated to SG3199, a pyrrolobenzodiazepine (PBD) dimer cytotoxin. In preclinical studies, ADCT-602 demonstrated potent anti-tumor activity in mouse models of B-cell malignancies. We present here interim

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16

Desikan, Sai Prasad, Farhad Ravandi, Naveen Pemmaraju, et al. "A Phase II Study of Azacitidine, Venetoclax and Trametinib in Relapsed/Refractory AML Harboring a Ras Pathway-Activating Mutation." Blood 138, Supplement 1 (2021): 4436. http://dx.doi.org/10.1182/blood-2021-151707.

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Abstract Background: Mutations in the RAS/RAF/MEK/ERK pathway result in resistance to several acute myeloid leukemia (AML) therapies, including hypomethylating agents (HMAs) plus venetoclax. Trametinib is an oral MEK inhibitor that has been studied as monotherapy in relapsed/refractory (R/R) AML with KRAS/NRAS mutations. Preclinical studies have suggested synergy between venetoclax and trametinib in RAS-mutated AML. We therefore sought to evaluate the combination of azacitidine, venetoclax, and trametinib in patients (pts) with R/R AML with Ras pathway-activating mutations. Methods: In this ph

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17

Short, Nicholas J., Guillermo Montalban-Bravo, Yesid Alvarado, et al. "Azacitidine, Venetoclax and Pevonedistat As Frontline Therapy for Patients with Secondary Acute Myeloid Leukemia Who Are Unfit for Intensive Chemotherapy: Results from a Phase I/II Study." Blood 138, Supplement 1 (2021): 2349. http://dx.doi.org/10.1182/blood-2021-153682.

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Abstract Background: Pevonedistat is a first-in-class inhibitor of NEDD8-activating enzyme that catalyzes the rate-limiting step of protein neddylation, a critical step in the degradation of cellular proteins that occurs upstream of the proteasome. The combination of azacitidine plus pevonedistat has resulted in high response rates and durable remissions in both myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), particularly in secondary AML (s-AML). Preclinical studies suggest that pevonedistat synergizes with venetoclax through neutralization of Mcl-1, providing rationale for t

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18

Short, Nicholas J., Hagop Kantarjian, Marina Konopleva, et al. "Updated Results of a Phase II Study of Ponatinib and Blinatumomab for Patients with Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia." Blood 138, Supplement 1 (2021): 2298. http://dx.doi.org/10.1182/blood-2021-153795.

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Abstract Background: Ponatinib and blinatumomab are both highly effective in Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). The combination of these two agents may lead to deep and durable responses, thereby reducing the need for both chemotherapy and allogeneic stem cell transplant (ASCT) in first remission. Methods: In this phase II study, adults with newly diagnosed (ND) Ph+ ALL, relapsed/refractory (R/R) Ph+ ALL, or chronic myeloid leukemia in lymphoid blast phase (CML-LBP) were eligible. Patients (pts) were required to have a performance status of ≤2, total bil

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19

Soumagne, Thibaud, Nicolas Guibert, Ihab Atallah, Yves Lacasse, Hervé Dutau, and Marc Fortin. "Dilation versus laser resection in subglottic stenosis: protocol for a prospective international multicentre randomised controlled trial (AERATE trial)." BMJ Open 12, no. 3 (2022): e053730. http://dx.doi.org/10.1136/bmjopen-2021-053730.

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IntroductionSubglottic stenosis (SGS) is a rare condition that results from progressive narrowing of the upper airways. Outcomes and treatment options depend on the benign or complex nature of the stenosis. Treatment options for SGS include surgery and endoscopic techniques. The main endoscopic techniques used are dilation and laser resection. Observational and retrospective studies suggest that endoscopic laser resection may be more effective than dilation. We, therefore, aimed to compare the effectiveness of dilation and laser resection in preventing recurrence of SGS.Methods and analysisAER

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20

Refaei, Mohammad, Bruna Fernandes, Joseph Brandwein, M. Dawn Goodyear, and Cynthia M. Wu. "Incidence of Catheter-Related Venous Thromboembolism Events in Acute Leukemia patients; A Comparative, Retrospective Study of the Safety of Peripherally-Inserted Vs Centrally-Inserted Central Venous Catheters." Blood 126, no. 23 (2015): 3546. http://dx.doi.org/10.1182/blood.v126.23.3546.3546.

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Abstract 1. Background Central venous catheters (CVCs) are a leading cause of upper extremity deep vein thrombosis (UE DVT). There is little data on patients with acute leukemia (AL). Long term CVCs are required for chemotherapy in AL. Concomitant severe thrombocytopenia makes anticoagulation for CVC related thrombosis a challenge. Incidence of UE DVT has been reported to be increased in those with peripherally inserted central venous catheters (PICC lines) vs those with centrally inserted lines. 2. Aims Our objective is to compare the incidence rate of VTE in leukemia inpatients with a PICC v

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21

Murphy, Adrianna, Benjamin Palafox, Marjan Walli-Attaei, et al. "The household economic burden of non-communicable diseases in 18 countries." BMJ Global Health 5, no. 2 (2020): e002040. http://dx.doi.org/10.1136/bmjgh-2019-002040.

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BackgroundNon-communicable diseases (NCDs) are the leading cause of death globally. In 2014, the United Nations committed to reducing premature mortality from NCDs, including by reducing the burden of healthcare costs. Since 2014, the Prospective Urban and Rural Epidemiology (PURE) Study has been collecting health expenditure data from households with NCDs in 18 countries.MethodsUsing data from the PURE Study, we estimated risk of catastrophic health spending and impoverishment among households with at least one person with NCDs (cardiovascular disease, diabetes, kidney disease, cancer and res

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22

Brown, Kevin, and Kristjan Paulson. "Characteristics of Hepatic Veno-Occlusive Disease from the Cell Therapy Transplant Canada Registry: A Retrospective Observational Study." Blood 136, Supplement 1 (2020): 18–19. http://dx.doi.org/10.1182/blood-2020-142237.

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Introduction:Hepatic venous occlusive disease (VOD) is a well-described early complication of allogeneic hematopoietic stem cell transplant (HSCT). The disease presents with elevated bilirubin, hepatomegaly, right upper quadrant pain, ascites and weight gain. Multi organ failure (MOF) can also occur, mainly renal and pulmonary failure, in severe cases. The incidence, pathogenesis, risk factors, and treatment of VOD remain poorly defined. Purpose:We aimed to determine the incidence of, risk factors, treatment patterns and resource utilization associated with VOD in Canada. Methods:Using the Cel

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23

Sharma, Manish, Mei-Jie Zhang, Xiaobo Zhong, et al. "Multiple Myeloma (MM) In Older (>70 year) Patients - Similar Benefit From Autologous Hematopoietic Cell Transplantation (AHCT) Compared With Younger Patients." Blood 122, no. 21 (2013): 416. http://dx.doi.org/10.1182/blood.v122.21.416.416.

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Abstract Background The median age at diagnosis of MM is 69 years. Randomized, controlled studies on the safety and effectiveness of AHCT are lacking in those > 70 years of age and many patients are considered “ineligible” on the basis of age. We analyzed survival (OS) outcomes of 11,430 MM patients from US and Canada receiving AHCT after high dose melphalan (MEL) between 2008 -2011 reported to the Center for International Blood and Marrow Transplant Research (CIBMTR). The relative efficacy of AHCT was compared in 3 cohorts; those aged ≥70 years (Cohort 1, n=946) vs. those 60-69 years (Coho

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24

Crump, Michael, John Kuruvilla, Stephen Couban, et al. "Gemcitabine, Dexamethasone, Cisplatin (GDP) Compared to Dexamethasone, Cytarabine, Cisplatin (DHAP) Chemotherapy Prior to Autologous Stem Cell Transplantation for Relapsed and Refractory Aggressive Lymphomas: Final Results of the Randomized Phase III NCIC CTG Study LY12." Blood 120, no. 21 (2012): 745. http://dx.doi.org/10.1182/blood.v120.21.745.745.

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Abstract Abstract 745 Background: The optimum chemotherapy combination prior to autologous stem cell transplantation (ASCT) for patients with relapsed or refractory aggressive non-Hodgkin lymphomas (NHL) has not been defined. We previously established the safety and efficacy of outpatient treatment with GDP in a phase II study (Crump et al, Cancer 2004) leading to this phase III trial testing the hypothesis that GDP is as effective and less toxic than standard DHAP, and potentially associated with better quality of life (QoL) and less resource utilization. Methods: Patients (pts) with relapsed

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25

Corbacioglu, Selim, Nancy A. Kernan, Antonio Pagliuca, Robert Ryan, William Tappe, and Paul Richardson. "Incidence of Post-Hematopoietic Stem Cell Transplantation (HSCT) Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome (VOD/SOS) without Hyperbilirubinemia at Diagnosis and Efficacy of Defibrotide in an Expanded-Access Program." Blood 132, Supplement 1 (2018): 2080. http://dx.doi.org/10.1182/blood-2018-99-117173.

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Abstract Introduction Hepatic VOD/SOS is a progressive, potentially life-threatening complication early post-HSCT, or of nontransplant chemotherapy. VOD/SOS diagnosis has been based on Baltimore (≤21 days post-HSCT and bilirubin ≥2 mg/dL plus ≥2 of: hepatomegaly, ascites, weight gain ≥5%) or modified Seattle (≤20 days post-HSCT and ≥2 of: bilirubin >2 mg/dL, hepatomegaly or right upper quadrant pain, weight gain [>5% in defibrotide studies]) criteria. Recent European Society of Blood and Marrow Transplantation (EBMT) VOD/SOS guidelines require elevated bilirubin only for adults diagnosed

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Pakulska, Daria, and Sławomir Czerczak. "Chloroethene. Documentation of proposed values of occupational exposure limits (OELs)." Podstawy i Metody Oceny Środowiska Pracy 35, no. 3(97) (2018): 19–69. http://dx.doi.org/10.5604/01.3001.0012.4766.

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Chloroethene (vinyl chloride) does not occur naturally in nature. It is obtained exclusively by chemical synthesis. It is a gas under normal pressure and temperature conditions. At 40-70 °C, it polymerizes to form polyvinyl chloride (PVC). It is a large-volume compound. Its annual global production exceeds 40 million t / year. About 98% of the total production is used to produce polyvinyl chloride (PVC) and copolymers. Chloroethene is also used in the synthesis of 1,1,1-trichloroethane (methyl chloroform) Exposure to chloroethene occurs during its synthesis and polymerization as well as during

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Roboz, Gail J., Guillermo Sanz, Elizabeth A. Griffiths, et al. "Results from a Global Randomized Phase 3 Study of Guadecitabine (G) Vs Treatment Choice (TC) in 302 Patients with Relapsed or Refractory (r/r) Acute Myeloid Leukemia after Intensive Chemotherapy (ASTRAL-2 Study)." Blood 138, Supplement 1 (2021): 2344. http://dx.doi.org/10.1182/blood-2021-147769.

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Abstract Background: Guadecitabine (G) is a next generation subcutaneous (SC) hypomethylating agent (HMA) resistant to degradation by cytidine deaminase which results in prolonged in vivo exposure to the active metabolite decitabine. We conducted a large global randomized phase 3 study (ASTRAL-2) of G vs TC in AML patients who were either refractory to or relapsed (r/r) after prior anthracycline-based intensive chemotherapy with or without hematopoietic cell transplant (HCT). Methods: r/r AML patients were randomized to G (60 mg/m 2 SC/d for 10 days in first 1-2 cycles followed by 5-day cycles

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Assouline, Sarit, Maria Cristina Miggiano, Elisabetta Abruzzese, et al. "Risk of Progression in Chronic Phase - Chronic Myeloid Leukemia (CML) Patients Eligible for Tyrosine Kinase Inhibitor Discontinuation (TFR-PRO study): Preliminary Results." Blood 138, Supplement 1 (2021): 1476. http://dx.doi.org/10.1182/blood-2021-150496.

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Abstract Background. Over 50% of CP-CML patients will achieve a deep molecular response (DMR) at some point during treatment with Tyrosine Kinase Inhibitors (TKI), where DMR is defined as BCR-ABL1 transcript levels lower than 1/10000 (or MR4). Treatment discontinuation (TD) in CP-CML patients with stable DMR is successful in approximately half of cases, with a relapse free survival (RFS) of 48-61% at 3 years. TD is considered safe, since MMR is achieved in almost all cases when TKI re-initiation is required. As such, treatment-free remission (TFR) is now usually attempted outside of clinical t

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29

Olszewski, Adam J., Lasse H. Jakobsen, Graham P. Collins, et al. "The Burkitt Lymphoma International Prognostic Index (BL-IPI)." Blood 136, Supplement 1 (2020): 46–49. http://dx.doi.org/10.1182/blood-2020-134985.

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Background. BL is a rare, high-grade B-cell lymphoma that is often studied in trials with small sample sizes. Historical definitions of "low-risk BL" vary between studies, use arbitrary cutoffs for lactate dehydrogenase (LDH), and identify a small favorable group, leaving &gt;80-90% of patients (pts) in an undifferentiated "high-risk" category. A validated prognostic index will help compare study cohorts and better define good-prognosis pts for whom reduced treatment would be appropriate vs a poor-prognosis group in need of new approaches. Herein, we constructed and validated a simplified

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Evens, Andrew M., Joseph M. Connors, Anas Younes, et al. "Older Patients (pts) with Previously Untreated Classical Hodgkin Lymphoma (cHL): A Detailed Analysis from the Phase 3 ECHELON-1 Study." Blood 132, Supplement 1 (2018): 1618. http://dx.doi.org/10.1182/blood-2018-99-112178.

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Abstract Background Survival rates for older pts with advanced HL (aged ≥60 yrs) were historically poor with doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD). Reasons may include decreased tolerance of therapy, increased toxicity (particularly with bleomycin), comorbidities, and disease biology. The pivotal phase 3 ECHELON-1 study demonstrated superior 2-yr modified progression-free survival (mPFS) with frontline brentuximab vedotin + doxorubicin, vinblastine and dacarbazine (A+AVD) vs ABVD in pts with stage III/IV cHL (Connors JM et al, NEJM 2018). The study allowed entry of older p

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Davies, Andrew J., Biljana Mihaljevic, Santiago Mercadal, et al. "Longer Term Efficacy and Safety of Subcutaneous Compared with Intravenous Rituximab: Updated Results of the Phase 3 SABRINA Study." Blood 128, no. 22 (2016): 1103. http://dx.doi.org/10.1182/blood.v128.22.1103.1103.

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Abstract Background: A new subcutaneous formulation of rituximab (RSC) has been developed which offers reduced treatment burden for patients compared to intravenous rituximab (RIV) as well as resource savings at the treatment facility. Additionally, availability of RSC would potentially allow patients to be treated primarily IV-free with orally administered partner therapies. The Phase 3 SABRINA study (NCT01200758) investigated induction RIV or RSC plus chemotherapy followed by maintenance RIV or RSC in patients with follicular lymphoma (FL). Pharmacokinetic non-inferiority was previously repo

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List, Alan F., Maria R. Baer, David P. Steensma, et al. "Two-Year Analysis of Efficacy and Safety of Deferasirox (Exjade®) Treatment in Myelodysplastic Syndrome Patients Enrolled in the US03 Study." Blood 114, no. 22 (2009): 3829. http://dx.doi.org/10.1182/blood.v114.22.3829.3829.

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Abstract Abstract 3829 Poster Board III-765 Introduction A large proportion of patients (pts) with myelodysplastic syndromes (MDS) become dependent on red blood cell (RBC) transfusions, escalating the risk of transfusional hemosiderosis and associated adverse effects. The US03 study was designed to evaluate the long-term efficacy and safety of the oral iron chelator, deferasirox, administered once-daily in pts with lower-risk MDS. 173 pts at 45 centers in the US and Canada enrolled in the 1-year core phase of the study and 83 pts participated in the 2-year extension phase. We now present data

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Dimopoulos, Meletios A., Judith Trotman, Alessandra Tedeschi, et al. "Ibrutinib Therapy in Rituximab-Refractory Patients with Waldenström's Macroglobulinemia: Initial Results from an International, Multicenter, Open-Label Phase 3 Substudy (iNNOVATETM)." Blood 126, no. 23 (2015): 2745. http://dx.doi.org/10.1182/blood.v126.23.2745.2745.

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Abstract Background: Current treatments for Waldenström's macroglobulinemia (WM) are not curative, and a standard of care does not exist. MYD88 L265P, a mutation identified in patients (pts) with WM, signals through interleukin-1 receptor-associated kinase 1 and Bruton's tyrosine kinase (BTK), leading to the constitutive activation of the NF-κB pathway (Yang, 2013). Ibrutinib (ibr), an oral inhibitor of BTK, attenuates the interaction between MYD88 and BTK and blocks BTK-dependent downstream signaling, inducing apoptosis of WM cells (Treon, 2012). In a phase 2 trial of ibr in previously treate

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McDonald, Cody L., Cynthia L. Bennett, Daniela K. Rosner, and Katherine M. Steele. "I AM THE BOY WITH ONE HAND WHO CAN DO ANYTHING”: PERCEPTIONS OF ABILITY AMONG PEOPLE WITH UPPER LIMB ABSENCE." Canadian Prosthetics & Orthotics Journal, December 15, 2018. http://dx.doi.org/10.33137/cpoj.v1i2.32001.

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INTRODUCTION Upper limb prostheses are commonly prescribed for people with upper limb absence (ULA) to restore function, cosmesis, and assist with activities of daily living. However, nearly one in five people with ULA chooses not to use a prosthesis1 and instead turns to alternative technology and adaptations, pointing to factors beyond prostheses that shape perceptions of ability and quality of life. We examined through interviews the lived experiences of people with ULA framed around their perceptions of ability, device use, and quality of life. Abstract PDF Link: https://jps.li

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Burton, Michael, and Steve Patten. "A Time for Boldness? Exploring the Space for Senate Reform." Constitutional Forum / Forum constitutionnel 24, no. 2 (2015). http://dx.doi.org/10.21991/c9nq37.

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It was thirty years ago this past March that Alberta’s Select Special Committee on Upper HouseReform released its influential 1985 report that helped to reframe discussions on Senate reformand popularize proposals for a “Triple-E” Senate. The Committee’s report built on the work ofa Canada West Foundation task force that argued eff ective regional representation in Parliament requires a Senate that is equal (in terms of provincial representation), elected, and effective (in terms of its legislative powers). The Alberta Committee’s Report popularized these ideas and helped to frame the Senate r

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M.L. McKelvey, Veronica, and Nicholas E. Mandrak. "Spatial and temporal patterns in the threats to at-risk freshwater fish species in Canada." Canadian Journal of Fisheries and Aquatic Sciences, November 14, 2023. http://dx.doi.org/10.1139/cjfas-2023-0170.

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This study identifies the current spatial and temporal patterns of threats to at-risk freshwater fishes within Canada. Data for 65 at-risk freshwater fishes were collated from the Committee on the Status of Endangered Wildlife in Canada Assessment and Status reports with threat calculators. Using these data, the overall threat impact level and the threat impact of the 11 categories in the threat calculator were compared for all species and separately by conservation status, which indicates their risk of extinction. These threats were also compared temporally to a study completed in 2006 and sp

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Wengerd, Lauren. "FUNCTIONAL UTILITY OF WEARING A MYOELECTRIC ORTHOSIS FOR UPPER EXTREMITY PARALYSIS DUE TO SPINAL CORD INJURY." Canadian Prosthetics & Orthotics Journal, December 15, 2018. http://dx.doi.org/10.33137/cpoj.v1i2.32021.

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INTRODUCTION Spinal cord injury (SCI) remains a leading cause of long-term disability in the United States with the majority of injuries resulting in incomplete quadriplegia due to cervical lesions.1 This leads to significant neurological impairment including upper extremity (UE) weakness and decreased independence with self-care activities of daily living (ADLs). Previous work demonstrated that using a myoelectric elbow-wrist-hand orthosis as a therapeutic adjunct to a multi-week rehabilitation regimen resulted in decreased UE motor impairment and increased function in stroke survivors

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Stark, Gerald E. "FACTOR ANALYSIS OF UPPER LIMB PROSTHETIC ACCEPTANCE FROM RETROSPECTIVE PROSTHETIC CLINICIAN SURVEY." Canadian Prosthetics & Orthotics Journal, December 15, 2018. http://dx.doi.org/10.33137/cpoj.v1i2.32045.

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INTRODUCTION Upper limb prosthetic acceptance seems to be relatively unchanged from 1958 where it was measured to be 75% for transradial, 61% for transhumeral, and 35% for shoulder disarticulation levels. A practitioner survey from 2013 by the author found this to be largely unchanged at 79.6%, 57.8%, and 32.8% respectively. An upper limb meta-analysis showed that the most significant factors affecting prosthetic rejection using a median rating were function, comfort, ease of use, weight, heat, lack of sensory feedback, inconvenience, lifestyle, dissatisfaction with technology, irritatio

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Brown, Steven, and Gary Trexler. "CASE STUDY: THERMOPLASTIC SCAPULOTHORACIC ORTHOSIS FOR TREATMENT OF WINGING SCAPULA." Canadian Prosthetics & Orthotics Journal, December 15, 2018. http://dx.doi.org/10.33137/cpoj.v1i2.32043.

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INTRODUCTION Winging scapula is a rare condition that can be painful and debilitating to the upper extremity involved1. This condition can affect the functional ability of the upper extremity, resulting in loss of range of motion, decreased power, and pain.1 The purpose of this study was to introduce and determine the clinical applicability of a custom thermoplastic scapulothoracic orthosis to aid in management of winging scapula. The thermoplastic scapulothoracic orthosis offers total contact and provides anterior-posterior compressive forces to stabilize the winging scapula. This desig

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Shoemaker, Eric. "MYOELECTRIC ELBOW-WRIST-HAND ORTHOSIS WITH ACTIVE GRASP FOR PATIENTS WITH STROKE: A CASE SERIES." Canadian Prosthetics & Orthotics Journal, December 15, 2018. http://dx.doi.org/10.33137/cpoj.v1i2.32022.

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INTRODUCTION This case series presents prescription, evaluation, fitting and initial functional benefits of a myoelectric elbow- wrist-hand orthosis with active grasp. Custom fit, myoelectric orthoses are now also being provided to patients with upper extremity paresis due conditions such as stroke, brachial plexus injury, spinal cord injury, multiple sclerosis and amyotrophic lateral sclerosis to enable them to self-initiate and control movement of a partially paretic limb using their own volitional myoelectric signals. A recent study of 18 chronic stroke participants demonstrated funct

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Popovic, Ivana, Andrea Cutti, Tiffany Ryan, et al. "DO MULTI-GRIP HANDS INCREASE FUNCTION AND PATIENT SATISFACTION WHEN COMPARED TO TRADITIONAL MYOELECTRIC HANDS?" Canadian Prosthetics & Orthotics Journal, December 15, 2018. http://dx.doi.org/10.33137/cpoj.v1i2.32049.

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INTRODUCTION Myoelectric hands progressed from single grip hands (traditional myoelectric devices (TH)) to be multi-grip hands (MGH) which are hypothesized to bring more degrees of freedom, greater range of motion and improved grasping capabilities1,2. Their impact on patients’ lives has been documented in only a few case studies. The Strategic Consortium for Upper Limb Prosthetic Technologies (SCULPT) aims to assess the potential benefits MGH with respect to function and patient satisfaction compared to TH systems. Abstract PDF Link: https://jps.library.utoronto.ca/index.php/cpoj/

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Mankoff, Jennifer, Saiph Savage, Sydney Eckert, Chelsea Ngo, and Goeran Fiedler. "USER EXPERIENCES WITH TRADITIONAL AND 3D-PRINTED UPPER EXTREMITY PROSTHESES, DEVELOPMENT OF A COMPREHENSIVE SURVEY INSTRUMENT." Canadian Prosthetics & Orthotics Journal, December 15, 2018. http://dx.doi.org/10.33137/cpoj.v1i2.32009.

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INTRODUCTION Additive Manufacturing (AM), colloquial known as 3D-printing, has been deemed capable to revolutionize a great number of industries, including the Health Care industry.1 In the field of upper limb prosthetics, it has been attempted to leverage the potential advantages of AM, such as crowd based design optimization, infrastructure independent fabrication, and economical material use, in the interest of providing low-cost, readily available devices to recipients whose needs were only insufficiently met by traditional approaches of device prescription and fitting. While the pop

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Campbell, Leah, Adriel Lau, Brittany Pousett, Ernie Janzen, and Silvia U. Raschke. "HOW INFILL PERCENTAGE AFFECTS THE ULTIMATE STRENGTH OF A 3D-PRINTED TRANSTIBIAL SOCKET." Canadian Prosthetics & Orthotics Journal, December 15, 2018. http://dx.doi.org/10.33137/cpoj.v1i2.32038.

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INTRODUCTION 3D printing for non‐weight‐bearing upper extremity prostheses is becoming increasingly popular as a method of fabrication.1 Some clinics in North America have begun using 3D printing to fabricate lower extremity diagnostic sockets (Figure 1). The strength requirements for upper extremity prostheses are not as rigorous as the strength requirements for lower extremity prostheses. Therefore, strength testing on 3D-printed lower extremity sockets is one of the first steps that needs to be conducted to ensure patient safety. 3D-printed prosthetic sockets are becoming an alternati

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MacKay-Barr, Megan, and Rick Csiernik. "An Exploration of Elder Abuse in a Rural Canadian Community." Critical Social Work 13, no. 1 (2019). http://dx.doi.org/10.22329/csw.v13i1.5847.

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The Elder Abuse Awareness Committee of Chatham Kent, Ontario employed ten seniors (65 years of age or older) from this rural community to conduct an investigation of the knowledge and prevalence of elder abuse among their peers. The 236 study participants interviewed by the specifically trained elders were predominantly female ranging in age from 55 to over 90. The majority were still living in their own homes, had completed high school or post-secondary education, and reported relatively good health. These attributes predicted a rate of disclosed elder abuse within the lower end of the four t

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Delgado, Cassandra, and Debra Latour. "USE OF EXTERNALLY-POWERED ORTHOSIS TO ADDRESS COMPLEXITIES ASSOCIATED WITH BILATERAL BRACHIAL PLEXOPATHY." Canadian Prosthetics & Orthotics Journal, December 15, 2018. http://dx.doi.org/10.33137/cpoj.v1i2.32047.

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INTRODUCTION Brachial plexus injuries are often caused by trauma, tumors or inflammation. The severity of the injury may vary, however in most traumatic cases, the supraclavicular region is impacted. Depending on the severity of the injury, surgery is often indicated early due to the likelihood of nerve regeneration. Surgical procedures include neurolysis, nerve grafting and neurotisation; where approximately 45% will regain adequate function to perform activities of daily living (ADLs) and return to work. According to current data, approximately 9,700 individuals per year will remain di

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Langlois, Jean, Yvan Dagenais, Marcel Martin, et al. "Spatial Abilities and Effect of Working Memory on Drawings of Objects from Haptic Perception." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.739.1.

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ObjectiveAs a basis for an application in anatomy education, vision‐based spatial abilities tests have been correlated with drawings of objects from haptic perception. Decreasing haptic perception while increasing working memory has been found to decrease performance on drawings of objects from haptic perception. The objective of the current study was to correlate spatial abilities to the effect of working memory on drawings of objects from haptic perception.MethodsA cohort of 24 medical graduates was enrolled in a prospective study. Ethics committee approval and written informed concent were

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Langlois, Jean, Yvan Dagenais, Marcel Martin, et al. "Spatial Abilities and Pictures of Objects Recognized from Haptic Perception: Effect of Short Term Memory." FASEB Journal 30, S1 (2016). http://dx.doi.org/10.1096/fasebj.30.1_supplement.570.1.

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ObjectiveAs a basis for an application in anatomy education, vision‐based spatial abilities tests have been correlated with pictures of objects recognized from haptic perception. The objective of the current study was to determine the effect of short term memory on the recognition of pictures of objects from haptic perception. The hypothesis is that the use of short term memory has a negative effect on the performance.MethodsA cohort of 48 medical graduates was enrolled in a prospective study. Ethics committee approval and written informed concent were obtained. Spatial abilities were measured

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Sholzberg, Michelle, Grace H. Tang, Elnara Negri, et al. "Coagulopathy of hospitalised COVID-19: A Pragmatic Randomised Controlled Trial of Therapeutic Anticoagulation versus Standard Care as a Rapid Response to the COVID-19 Pandemic (RAPID COVID COAG – RAPID Trial): A structured summary of a study protocol for a randomised controlled trial." Trials 22, no. 1 (2021). http://dx.doi.org/10.1186/s13063-021-05076-0.

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Abstract Objectives To determine the effect of therapeutic anticoagulation, with low molecular weight heparin (LMWH) or unfractionated heparin (UFH, high dose nomogram), compared to standard care in hospitalized patients admitted for COVID-19 with an elevated D-dimer on the composite outcome of intensive care unit (ICU) admission, non-invasive positive pressure ventilation, invasive mechanical ventilation or death up to 28 days. Trial design Open-label, parallel, 1:1, phase 3, 2-arm randomized controlled trial Participants The study population includes hospitalized adults admitted for COVID-19

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Roche, Matilda. "The Sniffles for Bear by B. Becker." Deakin Review of Children's Literature 2, no. 2 (2012). http://dx.doi.org/10.20361/g2fk5f.

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Becker, Bonny. The Sniffles for Bear. Cambridge, Mass.: Candlewick Press, 2011. Print Any book featuring the shenanigans of curmudgeonly Bear and winsome Mouse is met with enthusiasm in my house. Bear has a terrible cold and he responds to his condition with his usual verbose intolerance. Again, it is utterly creative and unstoppably committed Mouse - every introvert’s secret fantasy friend - to the rescue. While the dialogue is as snappy and satisfying as ever, it is Denton’s illustrations, their clean, clear detail and spot-on visual characterization that put these excellent books over the t

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Strungaru, Simona. "The Blue Beret." M/C Journal 26, no. 1 (2023). http://dx.doi.org/10.5204/mcj.2969.

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When we think of United Nations (UN) peacekeepers, the first image that is conjured in our mind is of an individual sporting a blue helmet or a blue beret (fig. 1). While simple and uncomplicated, these blue accessories represent an expression and an embodiment resembling that of a warrior, sent to bring peace to conflict-torn communities. UN peacekeeping first conceptually emerged in 1948 in the wake of the Arab-Israeli war that ensued following the United Kingdom’s relinquishing of its mandate over Palestine, and the proclamation of the State of Israel. “Forged in the crucible of practical d

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