Готові списки джерел за темами / Viral genetics

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  1. Статті в журналах
  2. Дисертації
  3. Книги
  4. Частини книг
  5. Тези доповідей конференцій
  6. Звіти організацій

Добірка наукової літератури з теми "Viral genetics"

Автор: Grafiati
Опубліковано: 4 червня 2021
Оновлено: 25 липня 2025

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Статті в журналах з теми "Viral genetics"

1

Wimmer, Eckard, and Rob Goldbach. "Viral genetics." Current Opinion in Genetics & Development 2, no. 1 (1992): 59–60. http://dx.doi.org/10.1016/s0959-437x(05)80322-3.

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2

Gao, Hong, and Marcus W. Feldman. "Complementation and Epistasis in Viral Coinfection Dynamics." Genetics 182, no. 1 (2009): 251–63. http://dx.doi.org/10.1534/genetics.108.099796.

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3

Fleuriet, Annie. "Evolution of the Proportions of Two Sigma Viral Types in Experimental Populations of Drosophila melanogaster in the Absence of the Allele That Is Restrictive of Viral Multiplication." Genetics 153, no. 4 (1999): 1799–808. http://dx.doi.org/10.1093/genetics/153.4.1799.

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Abstract A minority of flies in natural populations of Drosophila melanogaster are endemically infected by a rhabdovirus, sigma. The virus is vertically transmitted through male and female gametes. Two alleles of a fly locus, the ref(2)P locus, are present as a polymorphism in all populations: O permissive, and P restrictive for viral multiplication and transmission. Two viral types are known, Type I, which is very sensitive to the P allele, and Type II, which is more resistant. Previous observations have shown that, in presence of the P allele, viral Type II is selected for, in both natural a
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4

Lieberman, Paul M. "Epigenetics and Genetics of Viral Latency." Cell Host & Microbe 19, no. 5 (2016): 619–28. http://dx.doi.org/10.1016/j.chom.2016.04.008.

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5

Crill, W. D., H. A. Wichman, and J. J. Bull. "Evolutionary Reversals During Viral Adaptation to Alternating Hosts." Genetics 154, no. 1 (2000): 27–37. http://dx.doi.org/10.1093/genetics/154.1.27.

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Abstract Experimental adaptation of the bacteriophage ϕX174 to a Salmonella host depressed its ability to grow on the traditional Escherichia host, whereas adaptation to Escherichia did not appreciably affect growth on Salmonella. Continued host switching consistently exhibited this pattern. Growth inhibition on Escherichia resulted from two to three substitutions in the major capsid gene. When these phages were forced to grow again on Escherichia, fitness recovery occurred predominantly by reversions at these same sites, rather than by second-site compensatory changes, the more frequently obs
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6

Smith. "Genomics of Avian Viral Infections." Genes 10, no. 10 (2019): 814. http://dx.doi.org/10.3390/genes10100814.

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The poultry industry currently accounts for the production of around 118 million metric tons of meat and around 74 million metric tons of eggs annually. As the global population continues to increase, so does our reliance on poultry as a food source. It is therefore of vital importance that we safeguard this valuable resource and make the industry as economically competitive as possible. Avian viral infections, however, continue to cost the poultry industry billions of dollars annually. This can be in terms of vaccination costs, loss of birds and decreased production. With a view to improving
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7

Gratia, Jean-Pierre. "André Gratia: A Forerunner in Microbial and Viral Genetics." Genetics 156, no. 2 (2000): 471–76. http://dx.doi.org/10.1093/genetics/156.2.471.

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8

Stedman, Kenneth M., Christa Schleper, Evelyn Rumpf, and Wolfram Zillig. "Genetic Requirements for the Function of the Archaeal Virus SSV1 in Sulfolobus solfataricus: Construction and Testing of Viral Shuttle Vectors." Genetics 152, no. 4 (1999): 1397–405. http://dx.doi.org/10.1093/genetics/152.4.1397.

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Abstract Directed open reading frame (ORF) disruption and a serial selection technique in Escherichia coli and the extremely thermophilic archaeon Sulfolobus solfataricus allowed the identification of otherwise cryptic crucial and noncrucial viral open reading frames in the genome of the archaeal virus SSV1. It showed that the 15.5-kbp viral genome can incorporate a 2.96-kbp insertion without loss of viral function and package this DNA properly into infectious virus particles. The selection technique, based on the preferential binding of ethidium bromide to relaxed DNA and the resulting inhibi
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9

Adamson, Amy L., Kultaran Chohan, Jennifer Swenson, and Dennis LaJeunesse. "ADrosophilaModel for Genetic Analysis of Influenza Viral/Host Interactions." Genetics 189, no. 2 (2011): 495–506. http://dx.doi.org/10.1534/genetics.111.132290.

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10

Ekechukwu, M. C., D. J. Oberste, and B. A. Fane. "Host and phi X 174 mutations affecting the morphogenesis or stabilization of the 50S complex, a single-stranded DNA synthesizing intermediate." Genetics 140, no. 4 (1995): 1167–74. http://dx.doi.org/10.1093/genetics/140.4.1167.

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Abstract The morphogenetic pathway of bacteriophage phi X 174 was investigated in rep mutant hosts that specifically block stage III single-stranded DNA synthesis. The defects conferred by the mutant rep protein most likely affect the formation or stabilization of the 50S complex, a single-stranded DNA synthesizing intermediate, which consists of a viral prohead and a DNA replicating intermediate (preinitiation complex). phi X 174 mutants, ogr (rep), which restore the ability to propagate in the mutant rep hosts, were isolated. The org (rep) mutations confer amino acid substitutions in the vir
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Дисертації з теми "Viral genetics"

1

Beier, Kevin. "Viral Tracing of Neuronal Circuitry." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10241.

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To understand how the nervous system processes information, a map of the connections among neurons is essential. Viral transsynaptic transmission has gained popularity as a method for labeling neural circuits. In particular, the development of retrograde monosynaptic tracing vectors has enabled visualization of the pre-synaptic inputs onto defined sets of postsynaptic neurons. This system utilized the rabies virus (RABV), in which the glycoprotein gene in the virus was deleted, and re-supplied in trans. In order to build alternative, more flexible tracers, we made recombinant VSV genomes, firs
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2

James, Katherine Louise. "Viral genetics of HIV-2 infection." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:68ba022d-62e4-4cb1-8032-085ea5240b98.

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HIV-2 is a contemporary human retrovirus with the majority of infections localised to West Africa. Both HIV-1 and HIV-2 are able to cause AIDS; however, in contrast to HIV-1 infection, a common outcome following HIV-2 infection (&Tilde; 37&percnt; of patients in this study cohort) is long-term non-progression (LTNP), where patients remain aviraemic and asymptomatic in the absence of treatment, often for decades. HIV-1 and HIV-2 both arose following zoonotic transmission of SIVs from non-human primates at around the beginning of the 20<sup>th</sup> century and when patients develop AIDS caused
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3

Mills, Ryan E. "Improving gene annotation of complete viral genomes." Thesis, Georgia Institute of Technology, 2003. http://hdl.handle.net/1853/25189.

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Wilson, Jamie Douglas Knox. "Oligoclonal expansions of T lymphocytes during viral infections." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299227.

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5

Mistry, Ajay Ramanlal. "Development of non-viral gene delivery systems based on HMG1." Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368705.

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6

Ma, Hok-tsun, and 馬學俊. "RNA-Dependent RNA polymerase activity of the infectious bursal diseasevirus viral protein 1." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B30408192.

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Upton, John H. "The role of RNA secondary structure in replication of Nodamura virus RNA2." To access this resource online via ProQuest Dissertations and Theses @ UTEP, 2009. http://0-proquest.umi.com.lib.utep.edu/login?COPT=REJTPTU0YmImSU5UPTAmVkVSPTI=&clientId=2515.

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8

Shi, Bu-Jun. "Expression and function of cucumoviral genomes." Title page, contents and summary only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phs5546.pdf.

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Анотація:
Bibliography: leaves 104-130. The aim of this thesis is to characterise subgenomic RNAs of cucumoviruses and the functions of their encoding genes. Strains of cucumber mosaic virus (CMV) are classified into two major subgroups (I and II) on the basis of nucleotide sequence homology. The V strain of tomato aspermy virus (V-TAV) and a subgroup I CMV strain (WAII) are chosen to determine whether the 2b genes encoded by these viruses are expressed 'in vivo'. For further investigation of the 2b gene function, cDNA clones of three genomic RNAs of V-TAV are constructed. Using the infectious cDNA clon
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9

Song, Rujun. "Dimerization of human immunodeficiency virus type 1 genome : dimer maturation process and role of the 5' untranslated region in dimerization." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111918.

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Human Immunodeficiency Virus type I genome consists of two identical RNA molecules that are non-covalently linked to form a dimer. HIV-1 immature and mature genomic RNA (gRNA) dimers were found in protease defective (PR -) and wild type virions, respectively, and the 5'untranslated region (5' UTR) was shown to play key roles during the genome dimerization process; but the dimerization mechanism still remains to be clarified My research project is to characterize the dimerization process and the role of 5' UTR in genome dimerization in virions produced by tissue culture cells. I'll firstly show
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Lai, King-yin, and 賴景然. "Discovery and complete genome sequence of a novel group of bat picornavirus." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B44546026.

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Книги з теми "Viral genetics"

1

1968-, Galos Eli B., ed. Viral gene expression regulation. Nova Science Publishers, 2009.

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2

Galos, Eli B. Viral gene expression regulation. Nova Biomedical Books, 2010.

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3

Gerald, Myers, ed. Viral regulatory structures and their degeneracy. Addison-Wesley, 1998.

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4

1963-, Feng Zhi, and Long Ming, eds. Viral genomes: Diversity, properties, and parameters. Nova Science Publishers, 2009.

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5

Akhmatullina, N. B. Genetika virusov cheloveka i zhivotnykh. "Nauka" Kazakhskoĭ SSR, 1990.

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6

Bridgen, Anne. Reverse genetics of RNA viruses: Applications and perspectives. John Wiley & Sons, 2012.

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7

Catalano, Carlos Enrique. Viral Genome Packaging Machines: Genetics, Structure, and Mechanism. Springer US, 2005. http://dx.doi.org/10.1007/0-387-28521-0.

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8

M, Kyle Molly, ed. Resistance to viral diseases of vegetables: Genetics & breeding. Timber Press, 1993.

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9

Enrique, Catalano Carlos, ed. Viral genome packaging machines: Genetics, structure, and mechanism. Landes Bioscience/Eurekah.com, 2005.

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10

Esteban, Domingo, Holland John J, and Ahlquist Paul, eds. RNA genetics. CRC Press, 1988.

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Частини книг з теми "Viral genetics"

1

Levantis, P., R. Lambkin, M. Adawe, A. Al-Jabri, and J. S. Oxford. "Viral Drug Resistance." In Molecular Genetics of Drug Resistance. CRC Press, 2024. http://dx.doi.org/10.1201/9781003580775-3.

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2

Carter, Barrie J. "Molecular Genetics of Adeno-Associated Virus." In Viral Genome Methods. CRC Press, 2023. http://dx.doi.org/10.1201/9781003420163-15.

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3

Lowy, Douglas R. "Genetics of Retrovirus Tumorigenicity." In Concepts in Viral Pathogenesis II. Springer New York, 1986. http://dx.doi.org/10.1007/978-1-4612-4958-0_16.

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4

Gardner, Aaron, Sarah Stauffer, Lindsay Petley-Ragan, Philip Wismer, and Dewi Ayu Kencana Ungu. "Viral Gene Therapy." In Labster Virtual Lab Experiments: Genetics of Human Diseases. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-58744-7_4.

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5

Wilkinson, G. W. G., R. L. Darley, and P. R. Lowenstein. "Viral vectors for gene therapy." In From Genetics to Gene Therapy. Garland Science, 2024. http://dx.doi.org/10.1201/9781003580096-10.

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6

Birge, Edward A. "Fundamentals of Bacterial and Viral Genetics." In Bacterial and Bacteriophage Genetics. Springer New York, 1994. http://dx.doi.org/10.1007/978-1-4757-2328-1_1.

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Birge, Edward A. "Fundamentals of Bacterial and Viral Genetics." In Bacterial and Bacteriophage Genetics. Springer New York, 2000. http://dx.doi.org/10.1007/978-1-4757-3258-0_1.

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8

Wickner, R. B., H. Bussey, T. Fujimura, and R. Esteban. "Viral RNA and the Killer Phenomenon of Saccharomyces." In Genetics and Biotechnology. Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-662-10364-7_13.

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9

Catalano, Carlos Enrique. "Viral Genome Packaging Machines." In Viral Genome Packaging Machines: Genetics, Structure, and Mechanism. Springer US, 2005. http://dx.doi.org/10.1007/0-387-28521-0_1.

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10

Holmes, E. C., and A. J. Drummond. "The Evolutionary Genetics of Viral Emergence." In Current Topics in Microbiology and Immunology. Springer Berlin Heidelberg, 2007. http://dx.doi.org/10.1007/978-3-540-70962-6_3.

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Тези доповідей конференцій з теми "Viral genetics"

1

"Influence of viral suppressor expression on the activity of molybdoenzymes." In Plant Genetics, Genomics, Bioinformatics, and Biotechnology. Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 2019. http://dx.doi.org/10.18699/plantgen2019-069.

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2

Gillespie, Marc. "Capturing, Curating, and Sharing Viral Disease in Reactome." In Genomics and Human Genetics: The New York Symposium. Reactome, 2024. http://dx.doi.org/10.3180/poster/20240126gillespie.

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3

"The role of suppressor protein in acquired resistance to viral infection." In Plant Genetics, Genomics, Bioinformatics, and Biotechnology. Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 2019. http://dx.doi.org/10.18699/plantgen2019-193.

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4

"Antioxidant enzyme activities of plants under conditions of combined temperature and viral stress." In Plant Genetics, Genomics, Bioinformatics, and Biotechnology. Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 2019. http://dx.doi.org/10.18699/plantgen2019-010.

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5

"Expression of sheep pox viral A27L and L1R proteins in prokaryotic and eukaryotic systems." In Plant Genetics, Genomics, Bioinformatics, and Biotechnology. Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, 2019. http://dx.doi.org/10.18699/plantgen2019-023.

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6

Mukiibi, R., D. Robledo, C. Peñaloza, et al. "573. A major QTL affects resistance to viral nervous necrosis in farmed European seabass." In World Congress on Genetics Applied to Livestock Production. Wageningen Academic Publishers, 2022. http://dx.doi.org/10.3920/978-90-8686-940-4_573.

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7

Marii, Liliana, Larisa Andronic, Svetlana Smerea, and Natalia Balasova. "Evaluarea rolului genotipului în răspunsul antioxidativ la tomatele infectate cu virusuri." In VIIth International Scientific Conference “Genetics, Physiology and Plant Breeding”. Institute of Genetics, Physiology and Plant Protection, Republic of Moldova, 2021. http://dx.doi.org/10.53040/gppb7.2021.41.

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Анотація:
Studying the particularities of manifestation of defensive indicators – POX and PPO in case of in-fection with 2 types of viruses of different virus-host combinations (sensitive, tolerant, resistant) was per-formed in basis of analysis of variance. The obtained results denote a significant contribution of all ana-lyzed factors in the variability of PPO and POX indices, the major contribution returning to the genotype, followed by viral infection, the type of viral infection with a variable dose of contribution depending on the applied matrix. The PPO index expressed a higher specificity of the
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8

Mishchenko, Lidiya, Larisa Andronic, Mahbubjon Rahmatov, et al. "Wheat viruses don’t know borders: identification in Ukraine, Moldova and their impact on yield under global warming." In VIIIth International Scientific Conference “Genetics, Physiology and Plant Breeding”. Institute of Genetics, Physiology and Plant Protection, 2024. https://doi.org/10.53040/gppb8.2024.111.

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Анотація:
The early spring of 2024 contributed to emergence of viruses both in Ukraine and in neighboring Moldova. Already in April, wheat plants with signs of virus damage were selected in Vinnytsia and Dnipropetrovsk regions, and almost at the same time in Moldova. In May, the Wheat stripe mosaic virus (WSMV) was also discovered in Poltava. WMSV was detected in both countries, which has a significant epidemic potential, leading to a decrease in yield. In addition, in Ukraine, we continued to observe the manifestation of cold stress due to a daily temperature drop of more than 20ºC, which led to the ap
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Салтанович, Татьяна, Людмила Анточ та А. Дончилэ. "Особенности мужского гаметофита томата в условиях вирусного патогенеза и водного дефицита". У VIIth International Scientific Conference “Genetics, Physiology and Plant Breeding”. Institute of Genetics, Physiology and Plant Protection, Republic of Moldova, 2021. http://dx.doi.org/10.53040/gppb7.2021.25.

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On the example of F1 hybrid combinations and tomato varieties, the possibility of the assessing method for pollen selection on the responses of male gametophytes under conditions of viral pathogenesis and drought has been shown. It was found the action of factors on the pollen viability and on the rate of pollen tubes growth, leading to the manifestation of differential reactions. The viruses are the main sources of variability of the pollen functional traits, while the effect of water deficit and genotype are considerably weaker. Genotypes that combine the high viability of pollen with the ab
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Stingaci, Aurelia, and Leonid Volosciuc. "Isolate locale ale baculovirului entomopatogenic ca o tehnologie de formulare inovatoare, care protejează biopesticidul din degradare a radiației ultraviolete." In VIIth International Scientific Conference “Genetics, Physiology and Plant Breeding”. Institute of Genetics, Physiology and Plant Protection, Republic of Moldova, 2021. http://dx.doi.org/10.53040/gppb7.2021.91.

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This paper presents the conceptual conceptual vision a formulation technology for biopesticides in which the active ingredient (baculovirus) is an active coal. Importantly, this indgredient protects the sen-sitive viral DNA from degrading in sunlight, but dissolves in the alkaline insect gut to release the virus, which then infects and kills the pest. We show, using this ingredient, in both laboratory bioassays and field tests, that this can extend the efficacy of the biopesticide well beyond the few hours of existing virus formulations, potentially increasing the spray interval and reducing t
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Звіти організацій з теми "Viral genetics"

1

Ehrlich, Marcelo, John S. Parker, and Terence S. Dermody. Development of a Plasmid-Based Reverse Genetics System for the Bluetongue and Epizootic Hemorrhagic Disease Viruses to Allow a Comparative Characterization of the Function of the NS3 Viroporin in Viral Egress. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7699840.bard.

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Анотація:
Project Title: "Development of a plasmid-based reverse genetics system for the Bluetongue and Epizootic Hemorrhagic Disease viruses to allow comparative characterization of the function of the NS3 viroporin in viral egress". Project details: No - IS-4192-09; Participants – Ehrlich M. (Tel Aviv University), Parker J.S. (Cornell University), DermodyT.S. (Vanderbilt University); Period - 2009-2013. Orbiviruses are insect-borne infectious agents of ruminants that cause diseases with considerable economical impact in Israel and the United States. The recent outbreaks of BTV in Europe and of Epizoot
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2

Cahaner, Avigdor, Susan J. Lamont, E. Dan Heller, and Jossi Hillel. Molecular Genetic Dissection of Complex Immunocompetence Traits in Broilers. United States Department of Agriculture, 2003. http://dx.doi.org/10.32747/2003.7586461.bard.

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Objectives: (1) Evaluate Immunocompetence-OTL-containing Chromosomal Regions (ICRs), marked by microsatellites or candidate genes, for magnitude of direct effect and for contribution to relationships among multiple immunocompetence, disease-resistance, and growth traits, in order to estimate epistatic and pleiotropic effects and to predict the potential breeding applications of such markers. (2) Evaluate the interaction of the ICRs with genetic backgrounds from multiple sources and of multiple levels of genetic variation, in order to predict the general applicability of molecular genetic marke
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Vakharia, Vikram, Shoshana Arad, Yonathan Zohar, Yacob Weinstein, Shamila Yusuff, and Arun Ammayappan. Development of Fish Edible Vaccines on the Yeast and Redmicroalgae Platforms. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7699839.bard.

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Betanodaviruses are causative agents of viral nervous necrosis (VNN), a devastating disease of cultured marine fish worldwide. Betanodavirus (BTN) genome is composed of two single-stranded, positive-sense RNA molecules. The larger genomic segment, RNA1 (3.1 kb), encodes the RNA-dependent RNA polymerase, while the smaller genomic segment, RNA 2 (1.4kb), encodes the coat protein. This structural protein is the host-protective antigen of VNN which assembles to form virus-like particles (VLPs). BTNs are classified into four genotypes, designated red-spotted grouper nervous necrosis virus (RGNNV),
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Shaw, George M. Genetic Variation of HIV: Viral Load and Genotypic Diversity in Relation to Viral Pathogenesis and Treatment. Defense Technical Information Center, 1992. http://dx.doi.org/10.21236/ada246409.

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Cookmeyer, Donna M., and Steven A. Lommel. A Genetic Approach to the Identification of Plant Genes Involved in Viral Movement. Defense Technical Information Center, 1999. http://dx.doi.org/10.21236/ada392689.

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Wentworth, Jonathan. Digital sequence information. Parliamentary Office of Science and Technology, 2020. http://dx.doi.org/10.58248/pn630.

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Evolving life sciences and agricultural research approaches may have a decreasing need to access physical resources in future, such as plant seeds or viral material. Information and genetic data may be all that is required for commercial exploitation of biological resources. This POSTnote summarises the challenge this creates for international discussions on the governance of genetic resources and the possible options for addressing these.
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Mawassi, Munir, and Valerian V. Dolja. Role of the viral AlkB homologs in RNA repair. United States Department of Agriculture, 2014. http://dx.doi.org/10.32747/2014.7594396.bard.

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AlkB proteins that repair DNA via reversing methylation damage are conserved in a broad range of prokaryotes and eukaryotes including plants. Surprisingly, AlkB-domains were discovered in the genomes of numerous plant positive-strand RNA viruses, majority of which belong to the family Flexiviridae. The major goal of this research was to reveal the AlkB functions in the viral infection cycle using a range of complementary genetic and biochemical approaches. Our hypotheses was that AlkB is required for efficient replication and genetic stability of viral RNA genomes The major objectives of the r
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David, Lior, Yaniv Palti, Moshe Kotler, Gideon Hulata, and Eric M. Hallerman. Genetic Basis of Cyprinid Herpes Virus-3 Resistance in Common Carp. United States Department of Agriculture, 2011. http://dx.doi.org/10.32747/2011.7592645.bard.

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The goal of this project was to provide scientific and technical basis for initiating the development of breeding protocols using marker assisted selection for viral disease resistance in common carp. The specific objectives were: 1) Establishing families and characterizing the phenotypic and genetic variation of viral resistance; 2) Measuring the dynamics of immune response and developing a method to measure the long term immune memory; 3) Developing markers and generating a new genetic linkage map, which will enable initial QTL mapping; and, 4) Identifying genetic linkage of markers and cand
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Zelcer, Aaron, and George Bates. Asymmetric hybridization in crop plants: studies on cellular and genetic mechanisms and transfer of viral resistance. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7604276.bard.

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Tangkijvanith, Pisit. Prevalence and Clinical Significance of Hepatitis B Viral Genotypes and Mutations. Faculty of Medicine, Chulalongkorn University, 2006. https://doi.org/10.58837/chula.res.2006.24.

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Hepatitis B virus (HBV) infection is a major public health problem, with more than 400 million HBV carriers estimated worldwide. Chronic HBV infection is associated with a diverse clinical spectrum of liver damage ranging from asymptomatic carrier status, chronic hepatitis, cirrhosis, and hepatocellular carcinoma (HCC). There have been increasing lines of evidence to indicate influences of HBV genotypes and mutations on the outcome of liver disease, particularly the development of HCC. The project is aimed to study the prevalence and clinical significance of genotypes and mutations in Precore/
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