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Дисертації з теми "White matter structure"

Автор: Grafiati

Опубліковано: 11 березня 2023

Оновлено: 31 липня 2025

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1

Liu, Zao. "Measurement of White Matter Structure Changes in Amyotrohpic Lateral Sclerosis Using Fractal Analysis." Cleveland State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=csu1315930636.

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2

Clavenstam, Isabell. "The Effect of Methamphetamine Abuse on Brain Structure and Function." Thesis, University of Skövde, School of Humanities and Informatics, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-3106.

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<p>The great amount of METH abuse all over the world causes enormous social and criminal justice problems. In the human brain the abuse of METH causes implications on both structures and functions given rise to acute as well as long term symptoms. In this essay the effects of METH abuse is described in the manner of the drug mechanism such as the impact on neurotransmitters, structural deficits with decreased and increased volumes and the implication on attention, memory, decision making and emotions. Results from studies showing brain structural and cognitive impairments in METH abusers and

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3

McQueen, Jamie. "Vulnerability of white matter structure and function to chronic cerebral hypoperfusion and the effects of pharmacological modulation." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9544.

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The structural integrity of the white matter is required for neuronal communication within the brain which is essential for normal cognitive function. Post-mortem and clinical imaging studies of elderly individuals have demonstrated that white matter integrity is weakened with increasing age which is proposed to underlie age-related cognitive decline. Whilst the exact mechanisms are unknown it is thought that modest age-related reductions in cerebral blood flow, termed chronic cerebral hypoperfusion, may contribute to white matter disruption and impaired cognition with ageing. Investigating th

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4

Fenoll, Sanguino Raquel. "The influence of selected genetic and environmental factors on white matter pathway structure measured with diffusion tensor imaging." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/565943.

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The present doctoral thesis is focused on describing the effects that different environmental and genetic modulators have on white matter pathways and its consequences measured with diffusion tensor imaging. We chose to focus on two examples of each type of modulators. Firstly, we selected as environment modulating factors: pollutants and video games. On one side, pollution as an external factor that enters passively the brain and may influence developmental trajectories. And on the other hand, we used video games as a good example of active behavior that can modify white matter tracts throug

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5

Brubaker, Christopher John. "A Multimodal Magnetic Resonance Study of the Effects of Childhood Lead Exposure on Adult Brain Structure." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1248964743.

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6

Whitford, Thomas James. "A longitudinal study of brain structure in the early stages of schizophrenia." Thesis, The University of Sydney, 2007. http://hdl.handle.net/2123/1895.

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Schizophrenia is a severe mental illness that affects approximately 1% of the population worldwide, and which typically has a devastating effect on the lives of its sufferers. The characteristic symptoms of the disease include hallucinations, delusions, disorganized thought and reduced emotional expression. While many of the early theories of schizophrenia focused on its psychosocial foundations, more recent theories have focused on the neurobiological underpinnings of the disease. This thesis has four primary aims: 1) to use magnetic resonance imaging (MRI) to identify the structural brain ab

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7

Whitford, Thomas James. "A longitudinal study of brain structure in the early stages of schizophrenia." University of Sydney, 2007. http://hdl.handle.net/2123/1895.

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Doctor of Philosophy (PhD)<br>Schizophrenia is a severe mental illness that affects approximately 1% of the population worldwide, and which typically has a devastating effect on the lives of its sufferers. The characteristic symptoms of the disease include hallucinations, delusions, disorganized thought and reduced emotional expression. While many of the early theories of schizophrenia focused on its psychosocial foundations, more recent theories have focused on the neurobiological underpinnings of the disease. This thesis has four primary aims: 1) to use magnetic resonance imaging (MRI) to id

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8

Koivukangas, J. (Jenni). "Brain white matter structure, body mass index and physical activity in individuals at risk for psychosis:the Northern Finland Birth Cohort 1986 Study." Doctoral thesis, Oulun yliopisto, 2016. http://urn.fi/urn:isbn:9789526212869.

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Abstract Recognition of individuals at highest risk for psychosis is challenging and no definitive biomarkers are yet available. Physical illnesses associated with a sedentary lifestyle are common in patients with severe mental illness. Both, bodyweight and risk for psychosis are associated with brain white matter (WM) abnormalities. There are several dysregulated pathways which are common in psychiatric illnesses and weight-related processes, but it is not known how weight and vulnerability for psychosis interact in the brain. The present study examines brain WM microstructure and its associa

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9

DuBose, Lyndsey Elisabeth. "Role of aging and aerobic fitness on large elastic artery stiffness, brain structure and cognitive performance in humans." Thesis, University of Iowa, 2015. https://ir.uiowa.edu/etd/1590.

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Older age is a primary risk factor for the development of cardiovascular disease in part through the stiffening of the large cardiothoracic elastic arteries (e.g., aorta, carotid arteries). Aging is also associated with reduced cognitive function, cerebrovascular reactivity and brain white matter integrity, but whether these changes in brain structure and function are associated with age-related large artery stiffness remains unclear. In contrast, older adults who have high aerobic fitness demonstrate attenuated large artery stiffness and better cognitive performance compared to their sedentar

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10

Astolfi, Pietro. "Toward the "Deep Learning" of Brain White Matter Structures." Doctoral thesis, Università degli studi di Trento, 2022. http://hdl.handle.net/11572/337629.

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In the brain, neuronal cells located in different functional regions communicate through a dense structural network of axons known as the white matter (WM) tissue. Bundles of axons that share similar pathways characterize the WM anatomy, which can be investigated in-vivo thanks to the recent advances of magnetic resonance (MR) techniques. Diffusion MR imaging combined with tractography pipelines allows for a virtual reconstruction of the whole WM anatomy of in-vivo brains, namely the tractogram. It consists of millions of WM fibers as 3D polylines, each approximating thousands of axons. From t

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11

Engelbrecht, Kara. "Intraindividual variability and micro-structural white matter changes in Alzheimer’s disease." Master's thesis, Faculty of Humanities, 2019. http://hdl.handle.net/11427/31087.

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The costs associated with diagnosis, treatment and care of Alzheimer’s disease (AD) patients places a significant financial and social strain on healthcare systems, patients and caregivers, especially in low-and middle-income countries (LAMICs). Traditional methods for diagnosing AD are time consuming and expensive, and treatments are often only effective in the early stages. These factors call for the development of alternative diagnostic methods. One such method that has gained attention due to its neural overlaps with AD is the measurement of intraindividual variability (IIV; the within-per

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12

Zhang, Luduan. "QUANTIFYING BRAIN WHITE MATTER STRUCTURAL CHANGES IN NORMAL AGING USING FRACTAL DIMENSION." Case Western Reserve University School of Graduate Studies / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=case1126213038.

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13

Wassermann, Demian. "Automated in vivo dissection of white matter structures from diffusion magnetic resonance imaging." Nice, 2010. http://www.theses.fr/2010NICE4066.

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Le cerveau est organisé tel un réseau reliant différentes régions. Ce réseau est important pour le développement de fonctions comme le langage. Certains troubles cognitifs peuvent être expliqués par des problèmes de connexion entre régions plus qu’à des dommages de ces dernières. Malgré plusieurs décennies de travail sur ces réseaux, nos connaissances sur le sujet n’ont pas beaucoup évoluées depuis le début du siècle dernier. Récemment, un développement spectaculaire des techniques de l’imagerie par résonance magnétique (IRM) a permis l’étude vivant du cerveau humain. Une technique permettant

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14

Pannozzo, Mercede Alcina. "Effect of hypertension on the structural and functional integrity of the young and aged brain in an inducible transgenic model." Thesis, University of Edinburgh, 2014. http://hdl.handle.net/1842/9776.

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Hypertension has been associated with causing deleterious effects to the cerebrovasculature, which are thought to underlie the formation of white matter lesions (WML) and predispose individuals to age related cognitive decline. In humans hypertension frequently occurs concomitantly with other vascular risk factors making it difficult to ascertain the primary mechanisms of hypertension in isolation. Animal models of hypertension have been used in an aid to establish the mechanisms of hypertension in isolation. To date the knowledge gleaned from animal models has undoubtedly provided an insight

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15

Rowley, Jared. "White matter abnormailities and structural hippocampal disconnections in Alzheimer's disease and amnestic mild cognitive impairment." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116922.

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Objective: The purpose of this project was to evaluate white matter degeneration and its impact on hippocampal structural connectivity in patients with amnestic mild cognitive impairment, non-amnestic mild cognitive impairment and Alzheimer's disease.Methods: We estimated white matter fractional anisotropy, mean diffusivity and hippocampal structural connectivity in two independent cohorts. The ADNI cohort included 108 subjects [25 cognitively normal, 21 amnestic mild cognitive impairment, 47 non-amnestic mild cognitive impairment and 15 Alzheimer's disease]. A second cohort included 34 subjec

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16

Cheung, Vinci, and 張穎思. "Structural white matter abnormalities in never-medicated patients withfirst-episode schizophrenia: a diffusiontensor imaging study." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B39793734.

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17

Cheung, Vinci. "Structural white matter abnormalities in never-medicated patients with first-episode schizophrenia : a diffusion tensor imaging study /." View the Table of Contents & Abstract, 2008. http://sunzi.lib.hku.hk/hkuto/record/B39716375.

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18

Bajaj, Sahil, John R. Vanuk, Ryan Smith, Natalie S. Dailey, and William D. S. Killgore. "Blue-Light Therapy following Mild Traumatic Brain Injury: Effects on White Matter Water Diffusion in the Brain." FRONTIERS MEDIA SA, 2017. http://hdl.handle.net/10150/626295.

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Mild traumatic brain injury (mTBI) is a common and often inconspicuous wound that is frequently associated with chronic low-grade symptoms and cognitive dysfunction. Previous evidence suggests that daily blue wavelength light therapy may be effective at reducing fatigue and improving sleep in patients recovering from mTBI. However, the effects of light therapy on recovering brain structure remain unexplored. In this study, we analyzed white matter diffusion properties, including generalized fractional anisotropy, and the quantity of water diffusion in isotropic (i.e., isotropic diffusion) and

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19

Bodini, B. "Exploring the relationship between white and grey matter damage in primary progressive multiple sclerosis with structural magnetic resonance imaging." Thesis, University College London (University of London), 2013. http://discovery.ucl.ac.uk/1419097/.

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In the first part of this thesis, an introduction of the main characteristics of the primary-progressive form of multiple sclerosis (PPMS) (Chapter I), and of the acquisition and post-processing of the conventional and quantitative magnetic resonance imaging techniques employed in the studies presented in this thesis (Chapter II), will be presented. In the second part of this thesis, several advanced imaging techniques will be employed to answer the following two key questions on PPMS: 1) Is there is a spatial and temporal link between the pathological processes occurring in the normal appeari

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20

Popov, Alexandros. "Global inference of the structural connectivity of white matter fiber bundles using deep learning approaches and microstructural prior knowledge." Thesis, université Paris-Saclay, 2022. https://tel.archives-ouvertes.fr/tel-03789629.

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La cartographie de la connectivité anatomique du cerveau humain est un défi scientifique majeur. Décrire la trajectoire et les connexions réalisées par les cent milliards de neurones qui composent le cerveau est une tâche titanesque et multi-échelle.Les grands faisceaux ont été décrits par des approches anatomiques classiques dès le 20ème siècle. Ces travaux ont également révélé l'existence de faisceaux plus courts, appelés superficiels, qui définissent la connectivité entre les régions anatomiques voisines. La taille réduite et la forme complexe de ces faisceaux posent un sérieux défi à leur

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21

Bitzan, Lisa Valerie [Verfasser]. "Subtle Structural White Matter Changes Correlate with Positive Symptoms in Individuals at High Risk for Psychosis / Lisa Valerie Bitzan." Hamburg : Staats- und Universitätsbibliothek Hamburg Carl von Ossietzky, 2020. http://d-nb.info/1234150301/34.

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22

Schmit, Matthew Bolesaw. "Diffusion and Structural Magnetic Resonance Imaging of White Matter Pathology Can Predict Cognitive Performance in a Tract-Specific Manner." Thesis, The University of Arizona, 2014. http://hdl.handle.net/10150/321948.

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23

Choi, Ki Sueng. "Characterizing structural neural networks in major depressive disorder using diffusion tensor imaging." Diss., Georgia Institute of Technology, 2013. http://hdl.handle.net/1853/50353.

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Diffusion tensor imaging (DTI) is a noninvasive MRI technique used to assess white matter (WM) integrity, fiber orientation, and structural connectivity (SC) using water diffusion properties. DTI techniques are rapidly evolving and are now having a dramatic effect on depression research. Major depressive disorder (MDD) is highly prevalent and a leading cause of worldwide disability. Despite decades of research, the neurobiology of MDD remains poorly understood. MDD is increasingly viewed as a disorder of neural circuitry in which a network of brain regions involved in mood regulation is dysfun

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24

Young, Bob Neill. "Experimental neuropsychological tests of feature ambiguity, attention and structural learning : associations with white matter microstructural integrity in elderly with amnesic and vascular mild cognitive impairment." Thesis, University of Canterbury. Psychology, 2014. http://hdl.handle.net/10092/9367.

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Mild cognitive impairment (MCI) is a transition phase between normal aging and Alzheimer’s disease. Individuals with MCI show impairment in cognition as well as corresponding damage to areas of their brain. Performance on tasks such as discriminating objects with ambiguous features has been associated with damage to the perirhinal cortex, while scenes with structural (spatial) elements have been associated with damage to the hippocampus. In addition, attention is regarded as one of the first non-memory domains to decline in MCI. A relatively new MRI technique called diffusion tensor imaging (D

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25

Wikgren, Mikael. "Telomeres and the brain : an investigation into the relationships of leukocyte telomere length with functional and structural attributes of the brain." Doctoral thesis, Umeå universitet, Psykiatri, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-50634.

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Telomeres are the outermost parts of linear chromosomes. They consist of tandemly repeated non-coding short nucleotide sequences (TTAGGG in all vertebrates), in humans spanning over the last 2 to 15 kilobase pairs of the chromosome. Due to the end-replication problem, telomeres shorten with each cellular division. A critically short telomere will trigger the cell to enter a state of cellular senescence or to apoptose. The rate of telomere shortening can be accelerated by factors such as oxidative stress and inflammation. Taken together, this contributed to making telomere length a candidate bi

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26

Girard, Gabriel. "Tractographie de la matière blanche orientée par a priori anatomiques et microstructurels." Thesis, Nice, 2016. http://www.theses.fr/2016NICE4014/document.

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L’imagerie par résonance magnétique pondérée en diffusion est une modalité unique sensible aux mouvements microscopiques des molécules d’eau dans les tissus biologiques. Il est possible d’utiliser les caractéristiques de ce mouvement pour inférer la structure macroscopique des faisceaux de la matière blanche du cerveau. La technique, appelée tractographie, est devenue l’outil de choix pour étudier cette structure de façon non invasive. Par exemple, la tractographie est utilisée en planification neurochirurgicale et pour le suivi du développement de maladies neurodégénératives.Dans cette thèse,

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27

Yeo, Ronald A., Sephira G. Ryman, den Heuvel Martijn P. van, et al. "Graph Metrics of Structural Brain Networks in Individuals with Schizophrenia and Healthy Controls: Group Differences, Relationships with Intelligence, and Genetics." Cambridge University Press, 2016. https://tud.qucosa.de/id/qucosa%3A70691.

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Objectives: One of the most prominent features of schizophrenia is relatively lower general cognitive ability (GCA). An emerging approach to understanding the roots of variation in GCA relies on network properties of the brain. In this multi-center study, we determined global characteristics of brain networks using graph theory and related these to GCA in healthy controls and individuals with schizophrenia. Methods: Participants (N = 116 controls, 80 patients with schizophrenia) were recruited from four sites. GCA was represented by the first principal component of a large battery of neurocog

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28

Mancino, Antonio. "On the structural and dynamical properties of a new class of galaxy models with a central BH." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/18722/.

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This thesis work focuses on the dynamical properties of two-component galaxy models characterized by a stellar density distribution described by a Jaffe profile, and a galaxy (stars plus dark matter) density distribution following a r^(-3) shape at large radii. The dark matter (hereafter, DM) density profile is defined by the difference between the galaxy and the stellar profiles. The orbital structure of the stellar component is described by the Osipkov-Merritt (OM) radial anisotropy, and that of the DM halo is assumed isotropic; a black hole (BH) is also added at the center of the galaxy. T

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29

Beaujoin, Justine. "Post mortem inference of the human brain microstructure using ultra-high field magnetic resonance imaging with strong gradients." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS448/document.

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L’ambition des très hauts champs magnétiques (≥ 7T) à forts gradients (≥ 300mT/m) est de dépasser la résolution millimétrique imposée à plus bas champ pour atteindre l’échelle mésoscopique en neuroimagerie. Etudier le cerveau à cette échelle est essentiel pour comprendre le lien entre fonction et substrat anatomique. Malgré les progrès réalisés sur les aimants cliniques à 7T, il n’en est pas de même des gradients. Cette thèse vise à cartographier le cerveau humain à l’échelle mésoscopique via l’étude de pièces anatomiques post mortem. Une approche alternative a été choisie, reposant sur l'util

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30

Kulikova, Sofya. "Integration of multimodal imaging data for investigation of brain development." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015PA05T021/document.

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L’Imagerie par résonance magnétique (IRM) est un outil fondamental pour l’exploration in vivo du développement du cerveau chez le fœtus, le bébé et l’enfant. Elle fournit plusieurs paramètres quantitatifs qui reflètent les changements des propriétés tissulaires au cours du développement en fonction de différents processus de maturation. Cependant, l’évaluation fiable de la maturation de la substance blanche est encore une question ouverte: d'une part, aucun de ces paramètres ne peut décrire toute la complexité des changements sous-jacents; d'autre part, aucun d'eux n’est spécifique d’un proces

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31

Lakovic, Katarina. "The Effects of Bilirubin and its Oxidation Products on the Structure and Function of White Matter." Thesis, 2012. http://hdl.handle.net/1807/33300.

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Intracerebral hemorrhage (ICH) results in secondary brain injury caused partially by blood and its metabolites. Survivors of ICH are often left with severe disabilities, therefore, decreasing the extent of this secondary injury may improve functional outcome of patients. Incubation of mouse brain slices with partially oxidized bilirubin, a neurotoxic blood breakdown product, caused a dose- and time-dependent decrease in axonal function, suggesting a reduced number of conducting myelinated axons. These effects did not occur when tissue was incubated with non-oxidized bilirubin. Injection of bi

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32

Qi, Ting. "The brain structure during language development: neural correlates of sentence comprehension in preschool children." 2020. https://ul.qucosa.de/id/qucosa%3A71474.

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Language skills increase as the brain matures and language specialization is linked to the left hemisphere. Among distinct language domains, sentence comprehension is particularly vital in language acquisition and, by comparison, requires a much longer time-span before full mastery in children. Although accumulating studies have revealed the neural mechanism underlying sentence comprehension acquisition, the development of the brain’s gray matter and its relation to sentence comprehension had not been fully understood. This thesis employs structural magnetic resonance imaging and diffusion-we

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33

Chen, Pin-Yu, and 陳品妤. "Assessing white matter structure and covariance in normal aging and mild cognitive impairment using diffusion spectrum imaging and template-based tractography." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/3x2czj.

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博士<br>國立臺灣大學<br>生命科學系<br>105<br>Gray matter and white matter of the human brain degenerate with age. Using neuroimaging to characterize age-associated degenerative patterns in normal and pathological brain aging processes can help define normal aging and set up a reference for brain health exam. Previous neuroimaging studies on white matter fiber changes in healthy old people or patients with mild cognitive impairment (MCI) reported alteration of the tracts in the temporal-limbic regions and commissural fibers. The present thesis assumes that white matter tracts may be viewed as an inter-depen

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34

Marïë, Adham Mancini. "Differences in brain structure between males and females diagnosed with schizophrenia." Thèse, 2016. http://hdl.handle.net/1866/18559.

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Анотація:

Les progrès dans le domaine de la neuroimagerie cérébrale ont permis une certaine compréhension des maladies mentales comme la schizophrénie. Cependant, peu de résultats sont cohérents et ils sont souvent contradictoires, ce qui rend difficile de tirer des conclusions concrètes par rapport à la maladie. Plusieurs facteurs jouent un rôle dans les résultats divergents et convergents : Les différentes techniques d'imagerie et les analyses, le nombre de patients inclus dans les études, l'âge des patients, l'âge de l’'apparition de la maladie, les critères de diagnostic, les effets du traitement a

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35

Battocchio, Matteo. "Adaptive microstructure-informed tractography for accurate brain connectivity analyses." Doctoral thesis, 2022. https://hdl.handle.net/11562/1076527.

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Human brain has been subject of deep interest for centuries, given it's central role in controlling and directing the actions and functions of the body as response to external stimuli. The neural tissue is primarily constituted of neurons and, together with dendrites and the nerve synapses, constitute the gray matter (GM) which plays a major role in cognitive functions. The information processed in the GM travel from one region to the other of the brain along nerve cell projections, called axons. All together they constitute the white matter (WM) whose wiring organization still remains challen

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36

Zhang, Jian. "Linked structural-functional brain abnormalities in patients with multiple sclerosis." Doctoral thesis, 2020. http://hdl.handle.net/2158/1190128.

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Multiple sclerosis (MS) is a widespread inflammatory, demyelinating and neurodegenerative disease of the central nervous system (CNS). Various lines of evidence from magnetic resonance image (MRI) have proven that MS results in multiple structural abnormalities, in terms of grey matter (GM) atrophy, white matter (WM) lesions and microstructural damage as well as in functional connectivity abnormalities. Recently, some studies suggested that WM damage may be spatially linked with subsequent cortical and deep GM atrophy in primary progressive and longstanding MS. Other studies showed that most

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37

Brewster, Ryan. "White Matter Correlates of Verbal Memory in Left Temporal Lobe Epilepsy: A Study of Structural Connectivity." 2016. http://scholarworks.gsu.edu/psych_diss/161.

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Verbal memory deficits are among the most prominent cognitive sequelae in individuals with left temporal lobe epilepsy (LTLE). However, relationships between verbal memory function and white matter integrity (WMI) in the left temporal lobe remain unclear. Current study aims included determining fractional anisotropy (FA) and mean diffusivity (MD) differences as an index of WMI between participants with left temporal lobe epilepsy (LTLE), participants with right TLE (RTLE), and controls, establishing group differences based on verbal memory function between TLE groups, and describing relationsh

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Vieira, Carlos Marcelo Barbosa. "Structural variation of the insula and psychopathic traits: a community sample study." Master's thesis, 2019. http://hdl.handle.net/1822/61241.

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Dissertação de mestrado integrado em Psicologia<br>Psychopathy is a personality disorder marked by deficit in emotional processing, antisocial behavior, interpersonal manipulation and impulsive and erratic lifestyle. Functional and structural imaging studies have been used for analyses in cortical thinning and volume of grey and white matter in brain structures to identify the underlying abnormalities in psychiatric disorders. Previous studies indicate that individuals with psychopathy show an impaired response in the insula when processing emotional information, and this has been hypothesized

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Moayedi, Massieh. "Structural Brain Abnormalities in Temporomandibular Disorders." Thesis, 2012. http://hdl.handle.net/1807/34816.

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Temporomandibular disorders (TMD) are a family of prevalent chronic pain disorders affecting masticatory muscles and/or the temporomandibular joint. There is no unequivocally recognized peripheral aetiology for idiopathic TMD. The central nervous system (CNS) may initiate and/or maintain the pain in idiopathic TMD due to sustained or long-term nociceptive input that induces maladaptive brain plasticity, and/or to inherent personality-related factors that may reduce the brain's capacity to modulate nociceptive activity. The main aim of this thesis is to determine whether there are structural ne

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Tu, Chien-Kuang, and 杜建廣. "Relationships between Structural Integrity of Cerebral White Matter Tracts and Single- and Dual-Task Gait Performance in Cognitively Normal Middle-Aged and Older Adults: A Diffusion Spectrum Imaging Study." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/ak6fjh.

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碩士<br>國立臺灣大學<br>物理治療學研究所<br>105<br>Background: Gait performance and white matter tracts both decline with age. However, the relationship between the degeneration of white matter tracts and gait performance in middle-aged and older adults has not been comprehensively studied. Therefore, the aims of this study were to investigate whether spatiotemporal gait parameters under single- and dual-task walking conditions in cognitively normal middle-aged and older adults could be classified into independent domains, and whether the integrity of specific cerebral white matter tracts independently correl

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