Готові списки джерел за темами / Winnie mouse

Зміст

Статті в журналах
Дисертації
Книги
Тези доповідей конференцій

Добірка наукової літератури з теми "Winnie mouse"

Автор: Grafiati

Опубліковано: 10 січня 2023

Оновлено: 28 січня 2023

Оформте джерело за APA, MLA, Chicago, Harvard та іншими стилями

Оберіть тип джерела:

Ознайомтеся зі списками актуальних статей, книг, дисертацій, тез та інших наукових джерел на тему "Winnie mouse".

Біля кожної праці в переліку літератури доступна кнопка «Додати до бібліографії». Скористайтеся нею – і ми автоматично оформимо бібліографічне посилання на обрану працю в потрібному вам стилі цитування: APA, MLA, «Гарвард», «Чикаго», «Ванкувер» тощо.

Також ви можете завантажити повний текст наукової публікації у форматі «.pdf» та прочитати онлайн анотацію до роботи, якщо відповідні параметри наявні в метаданих.

Статті в журналах з теми "Winnie mouse"

Robinson, Ainsley M., Ahmed A. Rahman, Simona E. Carbone, Sarron Randall-Demllo, Rhiannon Filippone, Joel C. Bornstein, Rajaraman Eri, and Kulmira Nurgali. "Alterations of colonic function in the Winnie mouse model of spontaneous chronic colitis." American Journal of Physiology-Gastrointestinal and Liver Physiology 312, no. 1 (January 1, 2017): G85—G102. http://dx.doi.org/10.1152/ajpgi.00210.2016.

Повний текст джерела

Анотація:

The Winnie mouse, carrying a missense mutation in Muc2, is a model for chronic intestinal inflammation demonstrating symptoms closely resembling inflammatory bowel disease (IBD). Alterations to the immune environment, morphological structure, and innervation of Winnie mouse colon have been identified; however, analyses of intestinal transit and colonic functions have not been conducted. In this study, we investigated in vivo intestinal transit in radiographic studies and in vitro motility of the isolated colon in organ bath experiments. We compared neuromuscular transmission using conventional intracellular recording between distal colon of Winnie and C57BL/6 mice and smooth muscle contractions using force displacement transducers. Chronic inflammation in Winnie mice was confirmed by detection of lipocalin-2 in fecal samples over 4 wk and gross morphological damage to the colon. Colonic transit was faster in Winnie mice. Motility was altered including decreased frequency and increased speed of colonic migrating motor complexes and increased occurrence of short and fragmented contractions. The mechanisms underlying colon dysfunctions in Winnie mice included inhibition of excitatory and fast inhibitory junction potentials, diminished smooth muscle responses to cholinergic and nitrergic stimulation, and increased number of α-smooth muscle actin-immunoreactive cells. We conclude that diminished excitatory responses occur both prejunctionally and postjunctionally and reduced inhibitory purinergic responses are potentially a prejunctional event, while diminished nitrergic inhibitory responses are probably due to a postjunction mechanism in the Winnie mouse colon. Many of these changes are similar to disturbed motor functions in IBD patients indicating that the Winnie mouse is a model highly representative of human IBD. NEW & NOTEWORTHY This is the first study to provide analyses of intestinal transit and whole colon motility in an animal model of spontaneous chronic colitis. We found that cholinergic and purinergic neuromuscular transmission, as well as the smooth muscle cell responses to cholinergic and nitrergic stimulation, is altered in the chronically inflamed Winnie mouse colon. The changes to intestinal transit and colonic function we identified in the Winnie mouse are similar to those seen in inflammatory bowel disease patients.

Стилі APA, Harvard, Vancouver, ISO та ін.

De Santis, Stefania, Marina Liso, Mirco Vacca, Giulio Verna, Elisabetta Cavalcanti, Sergio Coletta, Francesco Maria Calabrese, et al. "Dysbiosis Triggers ACF Development in Genetically Predisposed Subjects." Cancers 13, no. 2 (January 14, 2021): 283. http://dx.doi.org/10.3390/cancers13020283.

Повний текст джерела

Анотація:

Background: Colorectal cancer (CRC) is the third most common cancer worldwide, characterized by a multifactorial etiology including genetics, lifestyle, and environmental factors including microbiota composition. To address the role of microbial modulation in CRC, we used our recently established mouse model (the Winnie-APCMin/+) combining inflammation and genetics. Methods: Gut microbiota profiling was performed on 8-week-old Winnie-APCMin/+ mice and their littermates by 16S rDNA gene amplicon sequencing. Moreover, to study the impact of dysbiosis induced by the mother’s genetics in ACF development, the large intestines of APCMin/+ mice born from wild type mice were investigated by histological analysis at 8 weeks. Results: ACF development in 8-week-old Winnie-APCMin/+ mice was triggered by dysbiosis. Specifically, the onset of ACF in genetically predisposed mice may result from dysbiotic signatures in the gastrointestinal tract of the breeders. Additionally, fecal transplant from Winnie donors to APCMin/+ hosts leads to an increased rate of ACF development. Conclusions: The characterization of microbiota profiling supporting CRC development in genetically predisposed mice could help to design therapeutic strategies to prevent dysbiosis. The application of these strategies in mothers during pregnancy and lactation could also reduce the CRC risk in the offspring.

Стилі APA, Harvard, Vancouver, ISO та ін.

Ranasinghe, Ranmali, Ruchira Fernando, Agampodi Promoda Perera, Madhur Shastri, Waheedha Basheer, Paul Scowen, Terry Pinfold, and Rajaraman Eri. "Ccr6 Deficiency Attenuates Spontaneous Chronic Colitis in Winnie." Gastrointestinal Disorders 2, no. 1 (February 10, 2020): 27–47. http://dx.doi.org/10.3390/gidisord2010004.

Повний текст джерела

Анотація:

Background: The immune-modulator behaviour of the CCR6/CCL20 axis in multi -system pathophysiology and molecular signalling was investigated at two clinically significant time points, using a Ccr6—deficient mouse model of spontaneous colitis. Methods:Four groups of mice, (C57BL/6J, Ccr6−/− of C57BL/6J, Winnie × Ccr6−/− and Winnie) were utilized and (I) colonic clinical parameters (2) histology of colon, spleen, kidney and liver (3) T and B lymphocyte distribution in the spleen and MLN by flowcytometry (5) colonic CCL20, phosphorylated PI3K and phosphorylated Akt expression by immunohistochemistry and (6) colonic cytokine expression by RT-PCR were evaluated. Results: CCR6 deficiency was shown to attenuate inflammation in the spleen, liver and gut while renal histology remained unaffected. Marked focal lobular inflammation with reactive nuclear features were observed in hepatocytes and a significant neutrophil infiltration in red pulp with extra medullary hemopoiesis in the spleen existed in Winnie. These changes were considerably reduced in Winnie × Ccr6−/− with elevated goblet cell numbers and mucus production in the colonic epithelium. Conclusions: Results indicate that Ccr6-deficiency in the colitis model contributes towards resolution of disease. Our findings demonstrate an intricate networking role for CCR6 in immune activation, which is downregulated by Ccr6 deficiency, and could provide newer clinical therapies in colitis.

Стилі APA, Harvard, Vancouver, ISO та ін.

Rahman, Ahmed A., Ainsley M. Robinson, Valentina Jovanovska, Rajaraman Eri, and Kulmira Nurgali. "Alterations in the distal colon innervation in Winnie mouse model of spontaneous chronic colitis." Cell and Tissue Research 362, no. 3 (July 31, 2015): 497–512. http://dx.doi.org/10.1007/s00441-015-2251-3.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Shinde, Tanvi, Ravichandra Vemuri, Sonia Shastri, Agampodi Promoda Perera, Shakuntla V. Gondalia, David J. Beale, Avinash V. Karpe, Rajaraman Eri, and Roger Stanley. "Modulating the Microbiome and Immune Responses Using Whole Plant Fibre in Synbiotic Combination with Fibre-Digesting Probiotic Attenuates Chronic Colonic Inflammation in Spontaneous Colitic Mice Model of IBD." Nutrients 12, no. 8 (August 9, 2020): 2380. http://dx.doi.org/10.3390/nu12082380.

Повний текст джерела

Анотація:

A probiotic and prebiotic food ingredient combination was tested for synergistic functioning in modulation of the colonic microbiome and remediation of the gastrointestinal immune and inflammatory responses in a spontaneous colitic mouse model. Bacillus coagulans MTCC5856 spores with capability to metabolise complex plant polysaccharides were supplemented with complex whole-plant prebiotic sugarcane fibre (PSCF). The combined and individual efficacies were tested for their influence on the outcomes of chronic inflammation in Muc2 mutant colitic Winnie mice. The mice were fed normal chow diet supplemented with either ingredient or a combination for 21 days. Synbiotic combined supplementation ameliorated clinical symptoms and histological colonic damage scores more effectively than either B. coagulans or PSCF alone. PSCF and B. coagulans alone also induced considerable immunomodulatory effects. Synbiotic supplementation however was the most efficacious in modulating the overall immune profile compared to the unsupplemented Winnie-control. The augmented synbiotic effect could potentially be due to a combination of increased levels of fermentation products, direct immune-modulating abilities of the components, their capability to reduce colonic epithelial damage and/or modulation of the microbiota. The beneficial effects of the supplementation with a complex plant fibre and a fibre-degrading probiotic parallel the effects seen in human microbiota with high plant fibre diets.

Стилі APA, Harvard, Vancouver, ISO та ін.

Movva, Ramya, Iulia Oancea, Chinwen Png, Amy S. Purdon, Saleh Y. Alabbas, Paraic O. Cuiv, and Timothy H. Florin. "An Antibiotic Cocktail that Results in a Dysbiotic Microbiome Improves Spontaneous Colitis in the Winnie Mouse." Gastroenterology 152, no. 5 (April 2017): S993. http://dx.doi.org/10.1016/s0016-5085(17)33365-6.

Повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Gundamaraju, Rohit, Ravichandra Vemuri, Wai Chin Chong, Stephen Myers, Shaghayegh Norouzi, Madhur D. Shastri, and Rajaraman Eri. "Interplay between Endoplasmic Reticular Stress and Survivin in Colonic Epithelial Cells." Cells 7, no. 10 (October 15, 2018): 171. http://dx.doi.org/10.3390/cells7100171.

Повний текст джерела

Анотація:

Sustained endoplasmic reticular stress (ERS) is implicated in aggressive metastasis of cancer cells and increased tumor cell proliferation. Cancer cells activate the unfolded protein response (UPR), which aids in cellular survival and adaptation to harsh conditions. Inhibition of apoptosis, in contrast, is a mechanism adopted by cancer cells with the help of the inhibitor of an apoptosis (IAP) class of proteins such as Survivin to evade cell death and gain a proliferative advantage. In this study, we aimed to reveal the interrelation between ERS and Survivin. We initially verified the expression of Survivin in Winnie (a mouse model of chronic ERS) colon tissues by using immunohistochemistry (IHC) and immunofluorescence (IF) in comparison with wild type Blk6 mice. Additionally, we isolated the goblet cells and determined the expression of Survivin by IF and protein validation. Tunicamycin was utilized at a concentration of 10 µg/mL to induce ERS in the LS174T cell line and the gene expression of the ERS markers was measured. This was followed by determination of inflammatory cytokines. Inhibition of ERS was carried out by 4Phenyl Butyric acid (4PBA) at a concentration of 10 mM to assess whether there was a reciprocation effect. The downstream cell death assays including caspase 3/7, Annexin V, and poly(ADP-ribose) polymerase (PARP) cleavage were evaluated in the presence of ERS and absence of ERS, which was followed by a proliferative assay (EdU click) with and without ERS. Correspondingly, we inhibited Survivin by YM155 at a concentration of 100 nM and observed the succeeding ERS markers and inflammatory markers. We also verified the caspase 3/7 assay. Our results demonstrate that ERS inhibition not only significantly reduced the UPR genes (Grp78, ATF6, PERKandXBP1) along with Survivin but also downregulated the inflammatory markers such as IL8, IL4, and IL6, which suggests a positive correlation between ERS and the inhibition of apoptosis. Furthermore, we provided evidence that ERS inhibition promoted apoptosis in LS174T cells and shortened the proliferation rate. Moreover, Survivin inhibition by YM155 led to a comparable effect as that of ERS inhibition, which includes attenuation of ERS genes and inflammatory markers as well as the promotion of programmed cell death via the caspase 3/7 pathway. Together, our results propose the interrelation between ERS and inhibition of apoptosis assigning a molecular and therapeutic target for cancer treatment.

Стилі APA, Harvard, Vancouver, ISO та ін.

Weaver, M., J. M. Yingling, N. R. Dunn, S. Bellusci, and B. L. Hogan. "Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development." Development 126, no. 18 (September 15, 1999): 4005–15. http://dx.doi.org/10.1242/dev.126.18.4005.

Повний текст джерела

Анотація:

In the mature mouse lung, the proximal-distal (P-D) axis is delineated by two distinct epithelial subpopulations: the proximal bronchiolar epithelium and the distal respiratory epithelium. Little is known about the signaling molecules that pattern the lung along the P-D axis. One candidate is Bone Morphogenetic Protein 4 (Bmp4), which is expressed in a dynamic pattern in the epithelial cells in the tips of growing lung buds. Previous studies in which Bmp4 was overexpressed in the lung endoderm (Bellusci, S., Henderson, R., Winnier, G., Oikawa, T. and Hogan, B. L. M. (1996) Development 122, 1693–1702) suggested that this factor plays an important role in lung morphogenesis. To further investigate this question, two complementary approaches were utilized to inhibit Bmp signaling in vivo. The Bmp antagonist Xnoggin and, independently, a dominant negative Bmp receptor (dnAlk6), were overexpressed using the surfactant protein C (Sp-C) promoter/enhancer. Inhibiting Bmp signaling results in a severe reduction in distal epithelial cell types and a concurrent increase in proximal cell types, as indicated by morphology and expression of marker genes, including the proximally expressed hepatocyte nuclear factor/forkhead homologue 4 (Hfh4) and Clara cell marker CC10, and the distal marker Sp-C. In addition, electron microscopy demonstrates the presence of ciliated cells, a proximal cell type, in the most peripheral regions of the transgenic lungs. We propose a model in which Bmp4 is a component of an apical signaling center controlling P-D patterning. Endodermal cells at the periphery of the lung, which are exposed to high levels of Bmp4, maintain or adopt a distal character, while cells receiving little or no Bmp4 signal initiate a proximal differentiation program.

Стилі APA, Harvard, Vancouver, ISO та ін.

Varga, Zoltán M., Angel Amores, Katharine E. Lewis, Yi-Lin Yan, John H. Postlethwait, Judith S. Eisen, and Monte Westerfield. "Zebrafishsmoothenedfunctions in ventral neural tube specification and axon tract formation." Development 128, no. 18 (September 15, 2001): 3497–509. http://dx.doi.org/10.1242/dev.128.18.3497.

Повний текст джерела

Анотація:

Sonic hedgehog (Shh) signaling patterns many vertebrate tissues. shh mutations dramatically affect mouse ventral forebrain and floor plate but produce minor defects in zebrafish. Zebrafish have two mammalian Shh orthologs, sonic hedgehog and tiggy-winkle hedgehog, and another gene, echidna hedgehog, that could have overlapping functions. To examine the role of Hedgehog signaling in zebrafish, we have characterized slow muscle omitted (smu) mutants. We show that smu encodes a zebrafish ortholog of Smoothened that transduces Hedgehog signals. Zebrafish smoothened is expressed maternally and zygotically and supports specification of motoneurons, pituitary cells and ventral forebrain. We propose that smoothened is required for induction of lateral floor plate and a subpopulation of hypothalamic cells and for maintenance of medial floor plate and hypothalamic cells.

Стилі APA, Harvard, Vancouver, ISO та ін.

Manna, Debashri, Saranya Chidambaranathan Reghupaty, Rachel Gredler Mendoza, Maria Del Camarena, Mark A. Subler, Jennifer Koblinski, Rebecca Martin, et al. "Abstract 920: Melanoma differentiation associated gene-9/syndecan binding protein (mda-9/sdcbp): A positive regulator of hepatocellular carcinoma." Cancer Research 82, no. 12_Supplement (June 15, 2022): 920. http://dx.doi.org/10.1158/1538-7445.am2022-920.

Повний текст джерела

Анотація:

Abstract Background: Hepatocellular carcinoma (HCC) is a major clinical challenge because of increasing rates of incidence and mortality, and high resistance to standard radio- and chemotherapy. Identification of novel molecules regulating HCC facilitates development of targeted therapies having a lasting impact on HCC patient survival. The oncogene MDA-9/SDCBP promotes tumorigenesis and metastasis in many cancers. In The Cancer Genome Atlas (TCGA), 8% of HCC patients show amplification of MDA-9 gene. However, the role of MDA-9 in regulating HCC has not been well-studied. Objective: To unravel the function of MDA-9 in HCC using a transgenic mouse model with hepatocyte-specific overexpression of MDA-9 (Alb/MDA-9). Study design: Alb/MDA-9 mice were generated in B6/CBA background by using the mouse albumin promoter/enhancer element to drive human MDA-9 expression. N-nitrosodiethylamine (DEN)/phenobarbital (PB) was used for induction of HCC. Tumor immune profile was analyzed by Opal multiplex staining and flow cytometry. RNA-sequencing (RNA-seq) was performed to analyze MDA-9-mediated gene regulation. Results: At 18 months of age, none of the WT mice developed liver tumor, while one male and one female Alb/MDA-9 mice (n = 11) developed one isolated tumor each, suggesting that MDA-9 may not be a strong driver oncogene, rather it might promote HCC progression once tumor is initiated. Indeed, at 32 weeks after induction of HCC using DEN/PB, tumor burden in the livers of Alb/MDA-9 mice was significantly higher compared to WT. These tumors showed loss of hepatic architecture and hepatocyte ballooning, features of HCC. Increased staining for the proliferation marker PCNA, HCC markers AFP and cytokeratin, and angiogenesis marker CD31 in tumor sections, and significantly increased levels of serum liver enzymes, AST and ALT, were observed in Alb/MDA-9 mice vs WT. Macrophage-mediated inflammation plays a central role in HCC. Compared to WT, Alb/MDA-9 tumors showed marked infiltration of CD11b+ myeloid cells, FoxP3+ T regulatory cells and F4/80+ macrophages. RNA-seq in naïve WT and Alb/MDA-9 hepatocytes identified activation of signaling pathways associated with invasion, angiogenesis and inflammation. Conclusions: MDA-9 overexpression in hepatocytes promotes HCC by stimulating inflammation, angiogenesis and immune modulation. Studies are ongoing to obtain in-depth understanding of the molecular mechanisms by which MDA-9 exerts these pleiotropic effects. This study was supported by NIH/NCI Grant 1R01CA244993-01 (DS and PBF). Citation Format: Debashri Manna, Saranya Chidambaranathan Reghupaty, Rachel Gredler Mendoza, Maria Del Camarena, Mark A. Subler, Jennifer Koblinski, Rebecca Martin, Mikhail G. Dozmorov, Swadesh K. Das, Jolene J. Windle, Paul B. Fisher, Devanand Sarkar. Melanoma differentiation associated gene-9/syndecan binding protein (mda-9/sdcbp): A positive regulator of hepatocellular carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 920.

Стилі APA, Harvard, Vancouver, ISO та ін.

Більше джерел

Дисертації з теми "Winnie mouse"

Costello, Peter James. "Formation of mousy off-flavour in wine by lactic acid bacteria." Title page, contents and summary only, 1998. http://web4.library.adelaide.edu.au/theses/09AHP/09ahpc841.pdf.

Повний текст джерела

Анотація:

Bibliography: leaves 200-214. Three structurally related compounds, 2-acetyltetrahydropyridine (ACTPY), 2-ethyltetrahydropyridine (ETPY) and N-heterocycle, 2-acetyl-1-pyrroline (ACPY), were quantified and found to be unique components of mousy wines. 35 lactic acid bacteria (LAB) were screened for the ability to produce mousy off-flavour. In addition to Lactobacillus brevis and L. cellobiosus, a diversity of LAB species, particularly heterofermentative Lactobacillus spp. and Oenococcus oeni exhibited this ability in a range of ethanolic and wine-based media. The substrates and metabolism of mousy compound formation by LAB were also investigated. A pathway for the formation of ACPY and ACTPY by heterofermentative LAB was proposed.

Стилі APA, Harvard, Vancouver, ISO та ін.

Senée, Jérôme. "Influence des macromolécules et des particules sur la stabilité des mousses de solutions hydroalcooliques complexes : application aux vins de Champagne." Vandoeuvre-les-Nancy, INPL, 1996. http://www.theses.fr/1996INPL141N.

Повний текст джерела

Анотація:

Dans ce travail, principalement expérimental, nous avons étudié à quelles conditions une solution hydroalcoolique acide de protéines et de glycoprotéines pouvait modéliser un vin mousseux au niveau de ses propriétés locales de surface (e. G. Tension superficielle et cinétique d'adsorption) et de film formé par une bulle à une surface libre (étudié par microinterférométrie) en corrélation avec ses propriétés globales de mousse. Cette étude est réalisée en présence ou non de particules hydrophiles bentonites, diatomées et levures utilisées lors de la fabrication du champagne. Nous avons étudié des solutions de bovine sérum albumine natives ou maltosées et des glycoprotéines levuriennes à des concentrations de l'ordre de la dizaine de mg/l en présence d'éthanol à des teneurs comprises entre 0 et 12% v/v. Nos résultats montrent que le comportement typique des films de vins mobiles pendant une dizaine de secondes puis stabilisés avec apparition simultanée d'agrégats est bien modélisé par une solution de glycoprotéines levuriennes à une concentration de 3 mg/l alors qu'il ne l'est pas par des solutions de BSA maltosées. Nous avons observé que le film isolé horizontal de vin est stable sous atmosphère saturée alors que sa mousse est instable. De plus, nous avons défini le rôle important, sur la déstabilisation des mousses de solutions hydroalcooliques, du drainage gravitaire et des composés volatils. Tous ces résultats ont pu être interprétés par les différences de conformation et de structuration des protéines étudiées à la surface induites par l'alcool. Nous avons montré que le potentiel zêta des particules, négatif dans toutes les solutions modèles, devient nul dans tous les vins, ce qui porterait à croire que les interactions électrostatiques n'interviennent pas dans la stabilisation des films de vin ; enfin, les propriétés locales et globales d'un vin filtré ne sont pas modifiées par l'ajout de particules aux concentrations moyennes mesurées dans les vins commercialisés

Стилі APA, Harvard, Vancouver, ISO та ін.

Robinson, Ainsley. "Stem cell therapies for the treatment of enteric neuropathy associated with inflammatory bowel disease." Thesis, 2019. https://vuir.vu.edu.au/39508/.

Повний текст джерела

Анотація:

Although not associated with mortality, symptoms, complications and the relapsing nature of inflammatory bowel disease (IBD) severely impact patient’s quality of life. Current treatments are coupled with side effects and loss of patient response. Damage to the enteric neurons is consistently associated with intestinal inflammation and considered to underlie the generation of symptoms. Therefore, the enteric neurons are a potential target for novel IBD therapies. Mesenchymal stem cells (MSCs) exhibit anti-inflammatory, immunomodulating, and neuroprotective effects and are demonstrated to participate in tissue regeneration and repair in many pathological conditions. Hence, they are a viable option for the treatment of enteric neuropathy associated with IBD. The studies in this thesis aim to investigate the effects of MSC therapy in averting enteric neuropathy in acute and chronic models of IBD. The results of our studies demonstrated that MSC and conditioned medium attenuated inflammation and averted enteric neuropathy and colonic dysmotility in an acute model of IBD. The effects of MSC treatment are dose-dependent and occur as early as 24h post treatment. We characterized changes to colonic innervation, motility, transit time, microbiota and metabolome in the Winnie mouse model of spontaneously occurring chronic colitis. Our results demonstrated that the Winnie mouse is highly representative of human IBD. The mechanisms underlying colonic dysmotility in Winnie mice were due to inhibition of neuromuscular transmission and smooth muscle responses. We found that multiple high dose MSC treatments induce anti-inflammatory and neurotrophic effects in mice with chronic colitis. Single dose and multiple low dose MSC administrations were ineffective in this model. Overall, we have established the capacity of MSC treatments to attenuate inflammation and enteric neuropathy in acute and chronic models of IBD. These findings are both novel and highly relevant for clinical translation and future investigations of MSC therapy for the treatment of IBD.

Стилі APA, Harvard, Vancouver, ISO та ін.

Книги з теми "Winnie mouse"

ill, Schindler S. D., ed. The big race. Mahwah, N.J: Troll Associates, 1989.

Знайти повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Once a mouse--: A fable cut in wood. 2nd ed. New York: Aladdin Books, 1989.

Знайти повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Disney Junior Coloring Book: Lilo and Stitch, Winnie the Pooh, Mickey Mouse, Finding Nemo, Toy Story, Monsters, Inc. , D. Princess and More... Independently Published, 2020.

Знайти повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

500+ Characters Coloring Book: Lilo and Stitch, Winnie the Pooh, Mickey Mouse, Finding Nemo, Toy Story, Monsters, Inc. , D. Princess and More... Independently Published, 2020.

Знайти повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Learn to Draw Disney Classic Characters: Learn to Draw Characters from Mickey Mouse and Friends, Winnie the Pooh, the Lion King, Toy Story, and More. Quarto Publishing Group USA, 2020.

Знайти повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Learn to Draw Disney Celebrated Characters Collection: New Edition! Includes Classic Characters, Such As Mickey Mouse and Winnie the Pooh, to Current Disney/Pixar Favorites. Quarto Publishing Group USA, 2018.

Знайти повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Disney Junior Coloring Book: For Kids Ages 4-8, Lilo and Stitch, Winnie the Pooh, Mickey Mouse, Finding Nemo, Toy Story, Monsters, Inc. , D. Princess and More... Independently Published, 2020.

Знайти повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Isney, D. 100+ Disney Characters Jumbo Coloring Book for Kids: Ultimate Disney Jumbo Coloring Book with High Quality Images Mickey and Minne Mouse,Winnie the Poo,Lightning Mcqueen,Princess Tiana and Lots More of Your Favourites. Independently Published, 2020.

Знайти повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Isney, D. Jumbo Coloring Book for Kids 100+ Disney Characters: Ultimate Jumbo Coloring Book with High Quality Images of All Your Favorite Characters,Mickey and Minnie Mouse,Winnie the Poo,Lightning Mcqueen, Princess Tiana and Lots More. Independently Published, 2020.

Знайти повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

various. Disney Scary Storybook Collection. Disney Press, 2008.

Знайти повний текст джерела

Стилі APA, Harvard, Vancouver, ISO та ін.

Тези доповідей конференцій з теми "Winnie mouse"

Binti Abd Rahman, Shazwina, M. Nurzawani Bin A Bakar, and Ariff Irfan Bin Zainai. "Collaborations Involving Malaysia Upstream Regulator to Enhance Decommissioning." In SPE Symposium: Decommissioning and Abandonment. SPE, 2021. http://dx.doi.org/10.2118/208468-ms.

Повний текст джерела

Анотація:

Abstract This paper aims to share the collaboration efforts of Malaysia's governing body for Upstream oil & gas industry with various stakeholders to enhance decommissioning in Malaysia. By virtue of Section of the Petroleum Development Act 1974, Petroliam Nasional Berhad (PETRONAS) ("PETRONAS") is vested with the entire ownership in, and the exclusive rights, powers, liberties and privileges of exploring, exploiting, winning and obtaining petroleum lying onshore or offshore of Malaysia. MPM manages the decommissioning liabilities for all Upstream petroleum facilities in Malaysia, specifically to strategize, regulate, promote, and drive decommissioning execution that is safe, cost-effective and brings the best benefit to the environment. Due to the shift in the industry with uncertainties in the long-term crude oil prices, depleting reserves, and operating cost challenges, it has made this non-revenue generating activity unavoidable. Thus, it is crucial to drive down decommissioning costs while protecting the environment. To achieve this objective, one of the focused initiatives pursued by MPM is through collaborations with relevant stakeholders such as industry players, upstream operators, government bodies, and academia. Such collaborations were found to be the fastest way to develop innovative solutions whereby the collaborators work together to achieve a common goal. Collaborations were done through, among others, constant and systematic engagements, workshops, brainstorming sessions, etc. A notable example would be in 2017, MPM successfully entered into a Memorandum of Understanding ("MOUs") with the Department of Fisheries ("DOF"), Ministry of Agriculture and Fishery Industry on rigs-to-reef. In 2020, MPM had successfully conducted a series of virtual workshops to capture decommissioning enhancement areas and lessons learnt with Operators and decommissioning contractors based on real-life experiences and past projects in Malaysia. A total of 115 enhancements areas were captured for consideration. Beyond these two items, MPM had successfully collaborated with many other stakeholders related to decommissioning and will continue to explore more collaborations in the future to support decommissioning in Malaysia. Details of these collaborations will be shared as part of this presentation. There were great experiences and important lessons that PETRONAS had learnt from these collaborations. PETRONAS believes that the culture of sharing experiences and lessons learnt will be the epitome for Operators and Contractors to work safely, stimulate creativity and strive towards decommissioning cost compression for every decommissioning project.

Стилі APA, Harvard, Vancouver, ISO та ін.

Ми пропонуємо знижки на всі преміум-плани для авторів, чиї праці увійшли до тематичних добірок літератури. Зв'яжіться з нами, щоб отримати унікальний промокод!