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Дисертації з теми "Wound healing Physiology"

Автор: Grafiati

Опубліковано: 4 червня 2021

Оновлено: 31 січня 2023

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1

Rippon, Mark Geoffrey. "The physiology of wound healing." Thesis, Manchester Metropolitan University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240980.

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2

Kesl, Shannon Lynn. "Metabolic Therapy for Age-Dependent Impaired Wound Healing." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6104.

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Chronic wounds represent an under-acknowledged socioeconomic epidemic, affecting 1.8 million new patients per year and costing the US health care system upwards of $25 billion annually. This substantial cost is rapidly growing due to a disproportionate occurrence in the ever-aging population. Key features associated with age-related impairment of wound healing include limited energy and nutrient exchange, unremitting inflammations, increased reactive oxygen species (ROS), and diminished blood flow. Most chronic wound therapies target specific molecular mechanisms; however, there are often mult

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3

Andreatta-Van, Leyen Sheila. "Experimental approaches for enhancing wound healing and inhibiting tumor growth." Case Western Reserve University School of Graduate Studies / OhioLINK, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=case1061557930.

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4

Mari, Walid Omran Dr. "Extracellular Microvesicles as a Novel Biomarker for Wound Healing." Wright State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=wright1495270509788421.

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5

Menke, Nathan. "A COMPUTATIONAL BIOLOGY APPROACH TO THE ANALYSIS OF COMPLEX PHYSIOLOGY: COAGULATION, FIBRINOLYSIS, AND WOUND HEALING." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2093.

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The birth of complexity research derives from the logical progression of advancement in the scientific field afforded by reductionist theory. We present in silico models of two complex physiological processes, wound healing and coagulation/fibrinolysis based on two common tools in the study of complex physiology: ordinary differential equations (ODE) and Agent Based Modeling (ABM). The strengths of these two approaches are well-suited in the analysis of clinical paradigms such as wound healing and coagulation. The complex interactions that characterize acute wound healing have stymied the d

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6

Roach, Necrisha. "The Development of a Novel Multi-dimensional Product for Wound Healing Applications." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2131.

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A characteristic feature of chronic wounds is a prolonged inflammatory response as well as susceptibility to infection. Studies have shown that during the inflammatory response, there is a significant increase in the levels of neutrophil-derived enzymes. The purpose of this work was to determine whether the anionic macromolecule polystyrene sulfonate (PSS) and five of its salt forms, namely PSS-calcium, PSS-chlorhexidine, PSS-doxycycline, PSS-glutathione and PSS-silver are able to inhibit the activity of three of the enzymes whose levels are elevated in chronic wounds: elastase, cathepsin G an

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7

Marshall, Nicholas John. "The influence of insulin-like growth factor 1 and its analogues on fibroblasts and dermal wound healing." Title page, table of contents and synopsis only, 1998. http://web4.library.adelaide.edu.au/theses/09MD/09mdm3685.pdf.

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Includes bibliography (leaves 191-219). Examines the levels of insulin-like growth factor and the presence of IGF binding proteins in human wound fluid. Tests the potency of IGF-1 and 2 analogues in in vitro models of fibroblast activity and their effect on healing in normal and diabetic rodent wounds. Shows that IGF-1, IGF-2 and their binding proteins are present in fluid from a partial thickness cutaneous wound; that the binding proteins negatively modulate the activity of insulin-like growth factors in vitro, but that the IGFs do not necessarily show enhanced activity in vivo at the wound s

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8

Sinno, Hani. "Role of collagen, complement C3, and C5 on cutaneous wound healing: topical formulation, preparation, and «in-vivo» evaluation in experimental rats." Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=66713.

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Анотація:

The growing rates of problematic wounds in the population and the subsequent increase in morbidity and mortality warrant further understanding of wound healing and the development of therapeutic agents targeted to alleviate these devastating concerns. The complement system is composed of bactericidal and hemolytic proteins that increase capillary leakage and inflammatory cell migration. It allows for an anaphylactic reaction and the recruitment of inflammatory cells. Fibroblast recruitment and subsequent collagen deposition in wounds is responsible for wound healing and is re

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9

Robertson, James Gray. "Insulin-like growth factors and insulin-like growth factor binding proteins in wounds /." Title page, contents and abstract only, 1999. http://web4.library.adelaide.edu.au/theses/09PH/09phr6509.pdf.

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10

Horobin, Adele Jayne. "Maggots and wound healing : the effects of Lucilia sericata larval secretions upon interactions between human dermal fibroblasts and extracellular matrix proteins." Thesis, University of Nottingham, 2005. http://eprints.nottingham.ac.uk/11516/.

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The introduction of necrophagous fly larvae (maggots) into chronic wounds for the purpose of inducing healing is an ancient practice that has recently undergone a renaissance in Western medicine. Through clinical observations, maggots are broadly recognised to debride the wound of necrotic tissue, cleanse the wound of infection and promote granulation tissue formation. Despite such recognition, little research at the biological level has been undertaken to identify the mechanisms by which maggots accomplish such feats. The dermal fibroblast is a major cellular component of granulation tissue a

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11

Kosmas, Kosmas [Verfasser], Angelika A. [Akademischer Betreuer] Noegel, and Jürgen [Akademischer Betreuer] Dohmen. "Cyclase associated protein 2: Roles in heart physiology and wound healing / Kosmas Kosmas. Gutachter: Angelika A. Noegel ; Jürgen Dohmen." Köln : Universitäts- und Stadtbibliothek Köln, 2014. http://d-nb.info/1069985848/34.

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12

Virchenko, Olena. "Stimulation of tendon repair by platelet concentrate, CDMP-2 and mechanical loading in animal models." Doctoral thesis, Linköping : Univ, 2007. http://www.bibl.liu.se/liupubl/disp/disp2007/med1005s.pdf.

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13

Stromme, Adrianna. "The characterization of the cytoskeleton and associated proteins in the formation of wound-induced contractile arrays /." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116078.

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The cytoskeleton is an intrinsic aspect of all cells, and is essential for many cellular events including cell motility, endocytosis, cell division and wound healing. Remodeling of the cytoskeleton in response to these cellular activities leads to significant alterations in the morphology of the cell. One such alteration is the formation of an actomyosin contractile array required for cytokinesis, wound healing and embryonic development.<br>Cellular structure and shape depends upon tensional prestress brought about by the organization of cytoskeletal components. Using the Xenopus laevis oocyte

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14

Ferrell, James R. ""Effects of nonthermal plasma on prokaryotic and eukaryotic cells"." Kent State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=kent1365781078.

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15

Kalyanaraman, Balaji. "Bioreactors to Demonstrate Process Automation and Regulate Physiology of Engineered Skin Substitutes." University of Cincinnati / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1210506859.

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16

Castellano-Pellicena, Irene. "The role of photoreceptors in human skin physiology; potential targets for light-based wound healing treatments. Identification of opsins and cryptochromes and the effect of photobiomodulation on human skin and in cultured primary epidermal keratinocytes and dermal fibroblasts." Thesis, University of Bradford, 2017. http://hdl.handle.net/10454/16884.

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The positive effect of photobiomodulation in wound healing has previously been reported, however there is a considerable lack of knowledge regarding the molecular mechanisms involved, and no consensus on light parameters. Cytochrome c oxidase (CCO) is established as the main photoreceptor in cells, but light also induces nitric oxide (NO), production of reactive oxygen species (ROS) and activation of ion channels. Emerging new molecular targets include the GPCRs opsins (OPNs) and the circadian clock transcription factors, cryptochromes (CRYs). Localisation of OPN1-SW, OPN3, OPN5, CRY1 and CRY

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17

Robles, Theodore F. "Stress, social support, and skin barrier recovery." Columbus, Ohio : Ohio State University, 2006. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1147705028.

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18

Hoyt, Laurie Christine. "Fibroblast Migration Mediated by the Composition of Tissue Engineered Scaffolds." VCU Scholars Compass, 2007. http://scholarscompass.vcu.edu/etd_retro/164.

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Tissue engineered scaffolds were constructed to mimic the native extracellular matrix (ECM) and promote cell migration of keratinocytes and fibroblasts. Electrospinning technology was used to fabricate these nano-scale matrices that consist of varying compositions and fiber diameters. The purpose of this study was to examine how average fiber diameter and scaffold composition regulate cell migration. Odyssey infrared scanning evaluated this on a macroscopic level, whereas confocal microscopy focused on a more microscopic approach. The expression of proteases released into the culture med

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19

Pillai, Mahesh Ramachandran. "Deciphering the Link Between Polychlorinated Biphenyls, Immune Function and Exercise." Bowling Green State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1510140839084446.

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20

Kilarski, Witold. "Mechanisms of Tissue Vascularization." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4819.

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21

Ferraro, Bernadette. "Intradermal Delivery of Plasmids Encoding Angiogenic Growth Factors by Electroporation Promotes Wound Healing and Neovascularization." [Tampa, Fla] : University of South Florida, 2009. http://purl.fcla.edu/usf/dc/et/SFE0002823.

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22

Anon, Ester. "Dynamique de la fermeture des trous épithéliaux en utilisant des techniques de micromécanique et de microfabrication." Phd thesis, Université René Descartes - Paris V, 2012. http://tel.archives-ouvertes.fr/tel-00793440.

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Les cellules peuvent migrer sous différentes conditions qui dépendent de l'environnement biochimique ou mécanique. Connaître les mécanismes de la migration, les protéines impliquées et leur régulation est essentiel pour comprendre les processus de morphogénèse ou certaines situations pathologiques. Dans ce contexte, la migration collective des cellules est un processus clé qui intervient pendant le développement ainsi que dans la vie adulte. Elle joue un rôle très important pour la formation et l'entretien des couches épithéliales, notamment au cours du développement embryonnaire et pendant la

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23

Teusner, Jacqueline Therese. "The molecular control of fetal wound healing / Jacqueline Therese Teusner." 2001. http://hdl.handle.net/2440/21784.

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"July, 2001"<br>Addendum inserted in back.<br>Includes bibliographical references (leaves 250-284)<br>xxiii, 284 leaves : ill. (some col.), plates (some col.) ; 30 cm.<br>Title page, contents and abstract only. The complete thesis in print form is available from the University Library.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Surgery, 2001

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24

Teusner, Jacqueline Therese. "The molecular control of fetal wound healing / Jacqueline Therese Teusner." Thesis, 2001. http://hdl.handle.net/2440/21784.

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"July, 2001"<br>Addendum inserted in back.<br>Includes bibliographical references (leaves 250-284)<br>xxiii, 284 leaves : ill. (some col.), plates (some col.) ; 30 cm.<br>Thesis (Ph.D.)--University of Adelaide, Dept. of Surgery, 2001

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25

Bux, Shamin. "Immunohistochemical and ultrastructural evaluation of the pathology and aetiopathogenesis of keloid formation." Thesis, 2013. http://hdl.handle.net/10413/11000.

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Introduction Keloids are formed by the excessive production of scar tissue, which extends beyond the margins of the original injury, often resulting in lesions of grotesque dimensions. Keloids present a major dilemma to surgeons because of the high recurrence rate with recurrent growth often larger than the original keloid. The high recurrence rate and the poor response of keloids to therapy present a great challenge to surgeons. The numerous therapeutic regimens demonstrate that to date there is no single therapy that is absolutely successful. Therefore, it is necessary to comprehensively est

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26

Marshall, Nicholas John. "The influence of insulin-like growth factor 1 and its analogues on fibroblasts and dermal wound healing." Thesis, 1998. http://hdl.handle.net/2440/38369.

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Includes bibliography (leaves 191-219).<br>x, 219 leaves<br>Examines the levels of insulin-like growth factor and the presence of IGF binding proteins in human wound fluid. Tests the potency of IGF-1 and 2 analogues in in vitro models of fibroblast activity and their effect on healing in normal and diabetic rodent wounds. Shows that IGF-1, IGF-2 and their binding proteins are present in fluid from a partial thickness cutaneous wound; that the binding proteins negatively modulate the activity of insulin-like growth factors in vitro, but that the IGFs do not necessarily show enhanced activity in

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27

Wabnitz, David Alexander Michael. "Factors affecting mucosal healing, reciliation, and ciliary function after endoscopic sinus surgery in the sheep." 2005. http://hdl.handle.net/2440/37719.

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The effect of absorbable packing on the healing of nasal respiratory epthelium after endoscopic sinus surgery (ESS) was examined in a diseased sheep model. Full thickness injuries were created on the lateral nasal wall of sheep infested with Oestrus ovi. Sites of injury were packed on one side with hyaluronic acid (HA) packing or hyaluronic acid packing impregnated with insulin-like growth factor- 1 (HA+IGF1) in a randomized fashion. The opposite side was left unpacked as a control. Biopsies were obtained for light microscopy, scanning electron microscopy, and ciliary beat frequency (CBF) anal

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28

Athanasiadis, Theodore. "The effect of topical antifibrinolytics and a novel chitosan gel on haemostasis and wound healing in endoscopic sinus surgery." 2009. http://hdl.handle.net/2440/58972.

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Introduction: Endoscopic sinus surgery (ESS) is at present the gold standard therapeutic modality for chronic rhinosinusitis (CRS) resistant to medical therapy. Whilst results from ESS for CRS are generally good, postoperative bleeding and impaired wound healing with adhesion formation remains a concern. Due to patient discomfort and the detrimental effects on wound healing caused by most packing materials, many surgeons no longer routinely use nasal packing. Surgeons have in the past sought agents which would provide post-operative haemostasis without detrimentally affecting wound healing. An

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29

Costa, Rita Alves. "Physiology of homeostasis and repair of skin and the role of metabolic and endrocrine factors." Doctoral thesis, 2016. http://hdl.handle.net/10400.1/10804.

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The skin is a multifunctional organ and the primal frontier to the external environment. It is the first line of defence against external aggressors and any injuries inflicted in the vertebrate skin are rapidly repaired to re-establish immune defence and integument homeostasis. In mammals the outcome of skin injury is repair and scaring but in other vertebrates such as amphibians and fishes’ regeneration of the skin occurs and the disrupted tissue is replaced by skin of the same architecture and functionality as the original. Skin regeneration in vertebrates has been poorly explore and c

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30

Bardou, Olivier. "Implications des canaux K+ sur la régulation génique du canal ENaC, et impact de l'hyperglycémie sur le transport ionique et la réparation de l'épithélium respiratoire." Thèse, 2012. http://hdl.handle.net/1866/12776.

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Dans mon projet de doctorat, j’ai étudié des fonctions primordiales de l’épithélium respiratoire telles que la régulation du transport ionique, la clairance liquidienne et la réparation épithéliale. J’ai particulièrement mis l’emphase sur le rôle des canaux potassiques qui interviennent dans ces trois fonctions de l’épithélium respiratoire. J’ai tout d’abord prouvé que la modulation des canaux potassiques régulait l’activité du promoteur de αENaC, en partie via la voie de signalisation ERK1/2, dans des cellules alvéolaires. Cette régulation entraîne une variation de l’expression génique et pro

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31

Mardaryev, Andrei N., N. Meier, Krzysztof Poterlowicz, A. A. Sharov, T. Y. Sharova, Mohammed I. Ahmed, Valentina Rapisarda, et al. "Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury." 2011. http://hdl.handle.net/10454/6079.

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The Lhx2 transcription factor plays essential roles in morphogenesis and patterning of ectodermal derivatives as well as in controlling stem cell activity. Here, we show that during murine skin morphogenesis, Lhx2 is expressed in the hair follicle (HF) buds, whereas in postnatal telogen HFs Lhx2(+) cells reside in the stem cell-enriched epithelial compartments (bulge, secondary hair germ) and co-express selected stem cell markers (Sox9, Tcf4 and Lgr5). Remarkably, Lhx2(+) cells represent the vast majority of cells in the bulge and secondary hair germ that proliferate in response to skin injury

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32

Dirks, Rachel Candace. "The individual and combined effects of exercise and collagenase on the rodent Achilles tendon." Thesis, 2014. http://hdl.handle.net/1805/4647.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>Tendinopathy is a common degenerative pathology that is characterized by activity related pain, focal tendon tenderness, intratendinous imaging changes, and typically results in changes in the histological, mechanical, and molecular properties of the tendon. Tendinopathy is difficult to study in humans, which has contributed to limited knowledge of the pathology, and thus a lack of appropriate treatment options. However, most believe that the pathology is degenerative as a result of a combination of both extrinsic and intrinsic facto

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