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Дисертації з теми "YAE1"

Автор: Grafiati
Опубліковано: 10 березня 2023

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1

Shah, Nupur R. "Functional studies of YAP1 in cancer and embryonic development." Thesis, University of Aberdeen, 2018. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=238733.

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The Hippo pathway is a master regulator of cell proliferation and organ size, namely through regulation of transcriptional co-activators YAP and TAZ which bind TEAD1-4 transcription factors. The Hippo effector YAP is dysregulated in many human solid tumours including rhabdomyosarcoma and oesophageal cancer. Additionally, persistent hyperactivity of YAP in activated but not quiescent satellite cells can give rise to embryonal rhabdomyosarcoma. However, the question of exactly how YAP acts as an oncogene and actively gives rise to tumour progression in these cancers remains unknown. In this thes
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2

Schlegelmilch, Karin [Verfasser]. "YAP1 and the Hippo Signaling Pathway Regulate Progenitor Proliferation / Karin Schlegelmilch." Berlin : Freie Universität Berlin, 2013. http://d-nb.info/1042186170/34.

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3

金原, 和江. "膜結合型プロテアーゼYaeLの機能解析". 京都大学 (Kyoto University), 2003. http://hdl.handle.net/2433/148589.

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4

Caetano, Soraia Cristina Marques. "O Yap1 no stress causado pelo excesso de cobalto em S. cerevisiae." Master's thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/8214.

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Mestrado em Biotecnologia<br>A capacidade dos organismos em alterar os seus padrões de expressão de genes em resposta a perturbações do meio ambiente é essencial para a sua viabilidade. Neste trabalho, utilizando Saccharomyces cerevisiae como organismo eucariota modelo, foi estudada a relevância do factor de transcrição da família Yap, o Yap1, na desintoxicação do excesso de cobalto. Os resultados obtidos neste trabalho demonstram que, após a incubação das células com cobalto, o factor de transcrição Yap1 é acumulado no núcleo, através de um mecanismo independente de Orp1/Gpx3. Verificámos que
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5

Sha, Wei. "Microarray data analysis methods and their applications to gene expression data analysis for Saccharomyces cerevisiae under oxidative stress." Diss., Virginia Tech, 2006. http://hdl.handle.net/10919/27840.

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Oxidative stress is a harmful condition in a cell, tissue, or organ, caused by an imbalance between reactive oxygen species or other oxidants and the capacity of antioxidant defense systems to remove them. These oxidants cause wide-ranging damage to macromolecules, including proteins, lipids, DNA and carbohydrates. Oxidative stress is an important pathophysiologic component of a number of diseases, such as Alzheimerâ s disease, diabetes and certain cancers. Cells contain effective defense mechanisms to respond to oxidative stress. Despite much accumulated knowledge about these responses, thei
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6

Fechtner, Tim [Verfasser]. "Charakterisierung der neuen, potentiellen Adhäsine Yaa1, Yaa2 und Yaa3 von Chlamydia pneumoniae / Tim Fechtner." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2013. http://d-nb.info/1036261921/34.

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7

Hegerfeldt, Yael [Verfasser], and Peter [Akademischer Betreuer] Friedl. "Kollektive Invasion in Melanomexplantaten: Bedeutung von Zell-Matrix-Interaktionen / Yael Hegerfeldt. Betreuer: Peter Friedl." Würzburg : Universitätsbibliothek der Universität Würzburg, 2012. http://d-nb.info/1028326785/34.

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8

Molina-Castro, Silvia. "Study of the Hippo/YAP1 signaling pathway in gastric carcinogenesis induced by Helicobacter pylori." Thesis, Bordeaux, 2017. http://www.theses.fr/2017BORD0623/document.

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Анотація:
Le cancer gastrique (CG) est une maladie multifactorielle, fréquemment associée à l’infection chronique par des souches CagA+ d’Helicobacter pylori. La transition épithélio-mésenchymateuse (EMT) est un processus réversible dans lequel une cellule épithéliale polarisée acquiert un phénotype mésenchymateux. L’EMT est à l’émergence de cellules souches cancéreuses (CSC) qui expriment CD44 et présentent une activité ALDH élevée. L’infection des cellules épithéliales gastriques humaines (CEGs) par CagA+ H. pylori induit des cellules CD44+ avec des propriétés des CSCs via une EMT. La voie Hippo est c
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9

Stegmeier, Johannes Friedrich. "Study of Omp85 family proteins YaeT and YtfM and multidrug export machineries in Escherichia coli." Doctoral thesis, [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=980586682.

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10

Guzzo, Cristiane Rodrigues. "Estudo estrutural e funcional das proteínas PilZ e YaeQ do fitopatógeno Xanthomonas axonopodis pv citri." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/46/46131/tde-26042010-134457/.

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Анотація:
O trabalho aqui desenvolvido teve como objeto o estudo estrutural e funcional de várias proteínas do fitopatógeno Xanthomonas axonopodis pv citri (Xac), dentre as quais se destacam as proteínas hipotéticas conservadas YaeQ e SufE, as proteínas RpfC, RpfF e RpfG envolvidas em quorum sensing e proteínas PilZ, FimX e PilB envolvidas na biogênese do pilus tipo IV. Para o desenvolvimento deste trabalho foram utilizadas diferentes técnicas incluindo: clonagem, expressão, purificação, desnaturação térmica, cristalografia, difração de raios-X, RMN, ensaios de 2-híbrido, produção de nocautes, mutação s
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11

ELSZTEIN, Carolina. "Identificação dos mecanismos moleculares de resistência ao polhexametileno biguanida na levedura Saccharomyces cerevisiae." Universidade Federal de Pernambuco, 2011. https://repositorio.ufpe.br/handle/123456789/6098.

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Анотація:
Made available in DSpace on 2014-06-12T18:01:57Z (GMT). No. of bitstreams: 2 arquivo7056_1.pdf: 2400536 bytes, checksum: 015771d94ec8f8e0629d6c5d29fdaf2d (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2011<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Quando submetidas a condições de estresse as células respondem a partir da indução de genes e ativação de proteínas em mecanismos regulados por cascatas de eventos metabólicos. Na levedura Saccharomyces cerevisiae muitos desses sinais externos são recebidos e amplifi
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12

Sethi, Sumedha. "Differences in TOR and Yak1 Gene Expression in the Mold and Yeast Phases of Penicillium marneffei." Youngstown State University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ysu1317910432.

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13

Jimenez, Carrera Adriana Patricia [Verfasser]. "Functional characterisation of ANKRD1 and its regulation by RASSF1A and YAP1 signalling / Adriana Patricia Jimenez Carrera." Gießen : Universitätsbibliothek, 2017. http://d-nb.info/1131551214/34.

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14

Masliantsev, Konstantin. "Rôle des signalisations STAT3 et Hippo dans les gliomes : Identification de nouveaux biomarqueurs pronostiques et cibles thérapeutiques." Thesis, Poitiers, 2018. http://www.theses.fr/2018POIT1407/document.

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Анотація:
Les gliomes malins sont les tumeurs les plus fréquentes du système nerveux central. Les glioblastomes représentant plus de 50% des gliomes, constituent la forme la plus agressive et sont particulièrement résistants à la radiochimiothérapie. Au sein de ces tumeurs réside une sous-population de cellules souches tumorales (CSG) qui pourrait être responsable de leurs initiation, progression et résistance aux traitements. Ces processus sont gouvernés par des voies de signalisation, pour la plupart activées de manière constitutive et dont l’étude est nécessaire afin de mieux comprendre les mécanisme
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15

Delaunay, Agnès. "Contrôle de l'homéostasie redox et détection des oxydants. Régulation du facteur de transcription Yap1 chez S. cerevisiae." Phd thesis, INAPG (AgroParisTech), 2002. http://tel.archives-ouvertes.fr/tel-00005660.

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Анотація:
Le maintien d'une homéostasie redox intracellulaire est essentielle à la survie de la cellule. Pour cela, la cellule doit réguler la concentration intracellulaire en intermédiaires réactifs de l'oxygène (ou IRO), sous-produits de la respiration. La connaissance que nous avons des mécanismes de contrôle de l'homéostasie redox repose principalement sur des données obtenues chez la bactérie. Nous avons donc choisi un eucaryote comme modèle d'étude, la levure S. cerevisiae. Le facteur de transcription Yap1 contrôle l'expression d'anti-oxydants, responsables en particulier de la réduction du peroxy
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16

Delaunay-Moisan, Agnès. "Contrôle de l'homéostasie redox et détection des oxydants : Régulation du facteur de transcription Yap1 chez S. cerevisiae." Paris, Institut national d'agronomie de Paris Grignon, 2002. http://www.theses.fr/2002INAP0013.

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Анотація:
Le maintien d'une homéostasie redox intracellulaire est essentielle à la survie de la cellule. Pour cela, la cellule doit réguler la concentration intracellulaire en intermédiaires réactifs de l'oxygène (ou IRO), sous-produits de la respiration. La connaissance que nous avons des mécanismes de contrôle de l'homéostasie redox repose principalement sur des données obtenues chez la bactérie. Nous avons donc choisi un eucaryote comme modèle d'étude, la levure S. Cerevisiae. Le facteur de transcription Yap1 contrôle l'expression d'anti-oxydants, responsables en particulier de la réduction du peroxy
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17

Lai, Kuan Han Jason [Verfasser], Didier [Gutachter] Stainier, and Virginie [Gutachter] Lecaudey. "The Hippo signaling transducers Yap1/Wwtr1 in zebrafish development / Jason Lai Kuan Han ; Gutachter: Didier Stainier, Virginie Lecaudey." Frankfurt am Main : Universitätsbibliothek Johann Christian Senckenberg, 2018. http://d-nb.info/1154485781/34.

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18

Guinto, Ferdiemar Cardenas Jr. "Investigating Secondary Structure Features of YAP1 Protein Fragments Using Molecular Dynamics (MD) and Steered Molecular Dynamics (SMD) Simulations." Scholarly Commons, 2017. https://scholarlycommons.pacific.edu/uop_etds/2973.

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Анотація:
Molecular dynamics (MD) is a powerful tool that can be applied to protein folding and protein structure. MD allows for the calculation of movement, and final position, of atoms in a biomolecule. These movements can be used to investigate the pathways that allow proteins to fold into energetically favorable structures. While MD is very useful, it still has its limitations. Most notable, computing power and time are of constant concern. Protein structure is inherently important due to the direct link between the structure of a protein and its function. One of the four levels of protein stru
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19

Wang, Xiaohui. "Role of TLRs, Hippo-YAP1 Signaling, and microRNAs in Cardiac Repair and Regeneration of Damaged myocardium During Ischemic Injury." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etd/3287.

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Cardiovascular disease is a leading cause of death in the United States. Toll-like receptor (TLR)-mediated pathways have been demonstrated to play a role in myocardial ischemia/reperfusion (I/R) injury. We and others have shown that PI3K/Akt signaling is involved in regulating cellular survival and protecting the myocardium from I/R induced injury. In this dissertation, we provide compelling evidence that miR-125b serves to “fine tune” TLR mediated NF-kB responses by repressing TNF-a and TRAF6 expression. We constructed lentiviral expressing miR-125b, delivered it into the myocardium. The data
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20

Schaal, Courtney. "Regulation of nAChRs and Stemness by Nicotine and E-cigarettes in NSCLC." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6582.

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Lung cancer is the leading cause of cancer-related death in both men and women, nationally and internationally and kills more people each year than breast, prostate, and colon cancers combined. Non-small cell lung carcinoma (NSCLC) is the most common histological subtype of lung cancer, and accounts for 85% of all cases. Cigarette smoking is the single greatest risk factor for lung cancer, and is correlated with 80-90% of all lung cancer deaths. Nicotine, the addictive component of tobacco smoke, is not a carcinogen and cannot initiate tumors itself; however, it is known to act as a tumor prom
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21

Yano, Taisuke. "Molecular basis of redox regulation by the yeast transcriptional factor Yap1 and its application to the development of redox probe." Kyoto University, 2009. http://hdl.handle.net/2433/126533.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第14872号<br>農博第1784号<br>新制||農||975(附属図書館)<br>学位論文||H21||N4487(農学部図書室)<br>27294<br>UT51-2009-K668<br>京都大学大学院農学研究科応用生命科学専攻<br>(主査)教授 阪井 康能, 教授 植田 和光, 教授 喜多 恵子<br>学位規則第4条第1項該当
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22

Schwartz, Stephanie. "Double-Diaspora in the Literature and Film of Arab Jews." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/20690.

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Inspired by the contrapuntal and relational critiques of Edward Said and Ella Shohat, this thesis conducts a comparative analysis of the literature and film of Arab Jews in order to deconstruct discourses on Jewish identity that privilege the dichotomies of Israel-diaspora and Arab-Jew. Sami Michael’s novel Refuge, Naim Kattan’s memoir Farewell, Babylon, Karin Albou’s film Little Jerusalem and b.h. Yael’s video documentary Fresh Blood: a Consideration of Belonging reveal the complexities and interconnections of Sephardic, Mizrahi and Arab Jewish experiences across multiple geographies that are
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23

Mata, Jaisa Angelica Vieira da. "Ensino de química com uso de tecnologias digitais para uma educação de jovens e adultos rejuvenescida." Universidade Federal de Goiás, 2018. http://repositorio.bc.ufg.br/tede/handle/tede/8677.

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Submitted by JÚLIO HEBER SILVA (julioheber@yahoo.com.br) on 2018-07-09T19:59:36Z No. of bitstreams: 2 Dissertação - Jaisa Angelica Vieira da Mata - 2018.pdf: 7684711 bytes, checksum: 3ea07869425a4a9680d8823b8a869e1d (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Approved for entry into archive by Luciana Ferreira (lucgeral@gmail.com) on 2018-07-10T11:34:57Z (GMT) No. of bitstreams: 2 Dissertação - Jaisa Angelica Vieira da Mata - 2018.pdf: 7684711 bytes, checksum: 3ea07869425a4a9680d8823b8a869e1d (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8
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24

Farhy, Yael [Verfasser], Harald [Akademischer Betreuer] Clahsen, and João [Akademischer Betreuer] Veríssimo. "Universals and particulars in morphology : processing and generalization in native and non-native speakers of Hebrew / Yael Farhy ; Harald Clahsen, João Veríssimo." Potsdam : Universität Potsdam, 2019. http://d-nb.info/1219515434/34.

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25

Bodiroža, Saša [Verfasser], Verena V. [Gutachter] Hafner, Yael [Gutachter] Edan, and Bruno [Gutachter] Lara. "Gestures in human-robot interaction : development of intuitive gesture vocabularies and robust gesture recognition / Saša Bodiroža ; Gutachter: Verena V. Hafner, Yael Edan, Bruno Lara." Berlin : Mathematisch-Naturwissenschaftliche Fakultät, 2017. http://d-nb.info/1126553557/34.

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26

Palmeri, Daniela. "Indagaciones sobre la reescritura del mito griego en el teatro contemporáneo. las orestíadas de la socìetas Raffaello Sanzio, mapa teatro, Rodrigo García y Yael Farber." Doctoral thesis, Universitat Autònoma de Barcelona, 2013. http://hdl.handle.net/10803/129369.

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La presente tesis realiza un estudio sobre la reescritura del mito griego en el teatro contemporáneo. El centro de la atención es la reescritura de la Orestíada, la tragedia esquilea en la que se representa el paso de una sociedad arcaica y violenta a una democrática, donde, sin embargo, el matricida queda impune. A lo largo de la historia cultural europea la Orestíada ha representado un importante modelo teatral así como un núcleo para reflexionar sobre el nexo entre tragedia, política y rito. Reescribir el mito significa deconstruir el imaginario y trabajar sobre las representaciones present
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27

Bochicchio, Anna [Verfasser], Paolo [Akademischer Betreuer] Carloni, Yael Mandel [Akademischer Betreuer] Gutfreund, and Jörg Ludwig [Akademischer Betreuer] Fitter. "Ligands and proteins targeting RNAs in human diseases : Structural and affinity predictions from atomistic simulations / Anna Bochicchio ; Paolo Carloni, Yael Mandel Gutfreund, Jörg Ludwig Fitter." Aachen : Universitätsbibliothek der RWTH Aachen, 2017. http://d-nb.info/1187251119/34.

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28

Monceau, Ludivine. "Identification des paramètres contrôlant l'état redox de Yap1, régulateur majeur de la réponse au stress oxydant et homéostasie des peroxydes chez la levure Saccharomyces cerevisiae." Paris 11, 2006. http://www.theses.fr/2006PA112100.

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Анотація:
Le contrôle de la concentration du peroxyde d'hydrogène [H2O2] est un processus essentiel à la survie des cellules. Chez S. Cerevisiae, le facteur de transcription Yap1 est le régulateur majeur de ce contrôle : il est activé par oxydation par l'H2O2, de façon indirecte, via Orp1, détecteur de l'H2O2 et transducteur de ce signal à Yap1. Nous avons, dans cette étude, exploré des déterminants de la régulation redox de Yap1. Nous avons identifié deux paramètres cruciaux dans cette régulation : la concentration d'H2O2 résiduelle qui, au-dessus d'un certain seuil, est responsable de la réoxydation i
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29

Rath, Chhang, Naret Heng, Chanrith Ngin, and Prachvuthy Men. "Community Saving and Economic Empowerment: A Case Study of the Village Development Bank (VDB) Model in Ta Yaek commune, Soutr Nikum district, Siem Reap province, Cambodia." 名古屋大学大学院国際開発研究科, 2014. http://hdl.handle.net/2237/19237.

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30

Patel, Geetika Jignesh [Verfasser]. "Kinetic Studies on the Effect of Skp and YaeT from Escherichia coli on the Insertion and Folding of Outer Membrane Protein A into Lipid Membranes / Geetika Jignesh Patel." Konstanz : Bibliothek der Universität Konstanz, 2009. http://d-nb.info/1028742770/34.

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31

Laloum, Tom. "Étude du rôle des facteurs de transcription MtNF-YA1 et MtNF-YA2 dans les étapes précoces de la symbiose rhizobienne chez medicago truncatula." Toulouse 3, 2013. http://thesesups.ups-tlse.fr/2215/.

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Анотація:
Les plantes de la famille des légumineuses sont capables d'établir une interaction symbiotique avec des bactéries du sol, collectivement appelées Rhizobia. Cette interaction aboutit à la formation d'un nouvel organe appelé nodule et dans lequel les bactéries différenciées fixent l'azote atmosphérique au bénéfice de la plante hôte. Les facteurs Nods (NFs) rhizobiens sont des molécules clés responsables de la spécificité d'hôte, et sont capables à eux seuls d'induire de nombreuses réponses développementales racinaires. MtNF-YA1 est un gène dont l'expression est fortement induite au cours du proc
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32

Macedo, Sheyla Maria Fontenele. "PrÃticas avaliativas na educaÃÃo de jovens e adultos em escolas da rede pÃblica de Fortaleza-CE: fator de inclusÃo escolar?" Universidade Federal do CearÃ, 2008. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=2618.

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nÃo hÃ<br>A presente pesquisa tem por objetivo fornecer subsÃdios teÃricos para reflexÃo no campo da avaliaÃÃo educacional frente Ãs prÃticas adotadas na educaÃÃo de jovens e adultos das sÃries iniciais do ensino fundamental e se estas favorecem ou nÃo o exercÃcio do direito à educaÃÃo, centrado no carÃter de permanÃncia, acesso e inclusÃo escolar do aluno. Para tanto, descortinou-se neste ensaio a âteceturaâ entre as concepÃÃes histÃricas da avaliaÃÃo no cenÃrio da educaÃÃo de jovens e adultos, da subjetividade individual e social que dÃo sustentaÃÃo à formaÃÃo da cultura escolar, por meio de
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33

Bersweiler, Antoine. "Les peroxydases à thiol, relais dans la signalisation cellulaire redox associée au peroxyde d’hydrogène : mécanismes moléculaires responsables de la spécificité de l’activation du facteur de transcription Yap1 chez Saccharomyces cerevisiae." Thesis, Université de Lorraine, 2015. http://www.theses.fr/2015LORR0270/document.

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Анотація:
Les peroxydases à thiol jouent un rôle central dans la physiologie du peroxyde d’hydrogène (H2O2), un oxydant possédant une fonction de messager cellulaire. Ces enzymes catalysent la réduction de H2O2 par réaction avec une Cys catalytique, ce qui leur confère la capacité de jouer le rôle de détecteur et relais du message redox. Chez Saccharomyces cerevisiae, l’activation H2O2-dépendante du facteur de transcription Yap1, un régulateur clef de la réponse au stress oxydant, dépend de la formation de ponts disulfure intramoléculaires catalysés par la peroxydase à thiol Orp1, via la réaction de l’i
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Fardini, Yann. "Étude du contrôle de l’expression des systèmes de sécrétion de type III, généré par l’inactivation du gène yfgL codant une lipoprotéine de la membrane externe, chez Salmonella Enteritidis." Thesis, Tours, 2008. http://www.theses.fr/2008TOUR3301/document.

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Les salmonelles, responsables de fièvres typhoïdes et gastro-entérites, sont un problème majeur de santé publique. Les systèmes de sécrétion de type III (TTSS) sont des facteurs de virulence cruciaux de Salmonella. Nos travaux ont montré que délétion du cadre ouvert de lecture yfgL conduit à une faible transcription des gènes codant les 3 TTSS conduisant à une baisse importante de la virulence de Salmonella Enteritidis. Or, la délétion de ce gène, dont la protéine chez E.coli est en complexe avec les protéines YaeT, YfiO, NlpB et SmpA, conduit à une altération de la membrane externe. Chez S. E
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横山, 俊彦, 啓隆 長田, 秀樹 村上 та ін. "O-28 YAP1は悪性胸膜中皮腫の増殖を促進し,NF2腫瘍抑制遺伝子で機能阻害される". 日本肺癌学会, 2007. http://hdl.handle.net/2237/11031.

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36

Miranda, Juliana. "Avaliação externa na educação de jovens e adultos: análises e perspectivas." Pontifícia Universidade Católica de São Paulo, 2013. https://tede2.pucsp.br/handle/handle/9740.

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Made available in DSpace on 2016-04-27T14:31:12Z (GMT). No. of bitstreams: 1 Juliana Miranda.pdf: 326367 bytes, checksum: 4e9dfbb5df0229c6baae1c2ec4764943 (MD5) Previous issue date: 2013-10-16<br>The Youngster and Adult Education (YAE) faces major challenges related to contemporary social and economic needs. If this system once has had the stigma that was enough to teach adults and adolescents who dropped out or never went to school to read and write his name, today YAE has the challenge of providing a broad and inclusive education that enables its students to not only be part of the l
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37

Puga, Cecília Maria Lopes. "A Educação de jovens e adultos (EJA): a inclusão social pelos caminhos da leitura." Universidade do Estado do Rio de Janeiro, 2008. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=4000.

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A dissertação trata de um estudo de natureza didática para uma reflexão sobre a leitura na Educação de Jovens e Adultos (EJA). Enfocamos a importância da formação de alunos com inúmeras pretensões e necessidades comunicativas, carentes da formação fundamental, que buscam a escola como oportunidade para que sejam reconhecidos e para validarem conhecimentos e competências resultantes de experiências construídas ao longo da vida, fora dos bancos escolares. O estímulo à prática da leitura revelou-se um dos caminhos para melhorar o letramento e contribuir para a inclusão social. Nas relações entre
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38

Oliveira, Luiz Renato de. "ENSINANDO E APRENDENDO COM PROJETOS TEMÁTICOS: UM DESAFIO PARA A FORMAÇÃO PERMANENTE DE EDUCADORES DA EDUCAÇÃO DE JOVENS E ADULTOS." Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/7212.

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This Master s Degree Dissertation sought to analyze with educators at permanent formation, the challenges to integrate the world reading of youths and adults in works with thematic project, making the relation between you - I more lively and participatory. The research thematic came to meet educators group of the researched school because it caused the reflection about real conditions of learners and their specificities since they are not children anymore (over 15 years old), excluded from school, and belonged to a disadvantaged social group. It brings the need of a knowledge approach related
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Rey, Thomas. "Mise en évidence et caractérisation d'interconnexions moléculaires entre symbiose et résistance chez la légumineuse modèle Medicago truncatula." Toulouse 3, 2013. http://thesesups.ups-tlse.fr/2191/.

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La rhizosphère, définie comme l'espace du sol qui entoure les racines, héberge de nombreux microorganismes à l'origine d'une grande variété d'interactions avec la plante. Au cours des dix dernières années, un grand nombre de gènes végétaux impliqués dans le dialogue moléculaire qui s'établit dans le cadre des différentes symbioses ou lors de la réponse de la plante aux parasites ont été identifiés. Les résultats de ces travaux ont notamment révélé l'existence de fortes similitudes entre les signaux et les récepteurs impliqués dans les deux types d'interactions. Toutefois, l'identification de g
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Santos, Cássia Oliveira. "Do dialogismo ao letramento: perspectivas para a leitura significativa na EJA." Pontifícia Universidade Católica de São Paulo, 2008. https://tede2.pucsp.br/handle/handle/14511.

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Made available in DSpace on 2016-04-28T19:34:26Z (GMT). No. of bitstreams: 1 Cassia Oliveira Santos.pdf: 577561 bytes, checksum: c8d36827a1fa3beb49f642b391e5a47b (MD5) Previous issue date: 2008-05-19<br>Secretaria da Educação do Estado de São Paulo<br>This work is in search line of Reading, Writing and Teaching of the Portuguese language and has as theme the study of the expansion of the degree of literacy of a person that is already literate in the Student Elementary School II of the Youth and Adults Education (YAE), through the teaching of meaningful reading, developed under school. We hav
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Ruotti, William. "A produção textual escrita na EJA: uma análise a partir dos estudos da análise crítica do discurso." Pontifícia Universidade Católica de São Paulo, 2008. https://tede2.pucsp.br/handle/handle/14516.

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Made available in DSpace on 2016-04-28T19:34:27Z (GMT). No. of bitstreams: 1 William Ruotti.pdf: 1658968 bytes, checksum: de945d3b9b1b1114fa71b9e9104251ce (MD5) Previous issue date: 2008-05-29<br>Secretaria da Educação do Estado de São Paulo<br>This work intended to talk about the posture of the Portuguese teacher while developing activities in the writing classes, in particular, in classrooms of high schools of the Youth and Adult Education (YAE). Today, it is said very in the knowledge that the student, in activities of writing, must possess to constitute its text of direction. In this sce
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Camponeschi, Francesca, Sabine Annemarie Elisabeth Heider, Simone Ciofi-Baffoni, and Lucia Banci. "Characterization of pathways for the Fe-S protein biogenesis in the human cytoplasm." Doctoral thesis, 2020. http://hdl.handle.net/2158/1217050.

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Human cytosolic monothiolglutaredoxin-3 (GLRX3) is a protein essential for the maturation of cytosolic [4Fe−4S] proteins. We show here that dimeric cluster-bridged GLRX3 transfers its [2Fe−2S]2+ clusters to the human P-loop NTPase NUBP1, an essential early component of the cytosolic iron−sulfur assembly (CIA) machinery. Specifically, we observed that [2Fe−2S]2+ clusters are transferred from GLRX3 to monomeric apo NUBP1 and reductively coupled to form [4Fe−4S]2+ clusters on both N-terminal CX13CX2CX5C and C-terminal CPXC motifs of NUBP1 in the presence of glutathione that acts as a reductant.
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"Functions of Yap1 in endochondral bone development and regeneration." 2015. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1291703.

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Deng, Yujie.<br>Thesis Ph.D. Chinese University of Hong Kong 2015.<br>Includes bibliographical references (leaves 141-167).<br>Abstracts also in Chinese.<br>Title from PDF title page (viewed on 07, November, 2016).
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Wright, Laurence. "Confronting the African nightmare: Yael Farber’s SeZaR (theatre review)." 2001. http://hdl.handle.net/10962/d1007388.

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Yael Farber’s adaptation of Julius Caesar marks something of a breakthrough in South African Shakespeare productions. The key achievement is that the play is no longer about Rome or Renaissance England, nor is it about processes of cultural translation or trendy theatrical Africanisation, largely cosmetic. This production is, in a generous way, squarely and pointedly about Africa.
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Tsai, Michelle. "RGC1/RGC2 deletions cause increased sensitivity to oxidative stress in Saccharomyces cerevisiae, which can be overcome by constitutive nuclear Yap1 expression." Thesis, 2014. https://hdl.handle.net/2144/15092.

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Oxidative stress mechanism in yeast presents an innovative pathway to understand in creating the next generation of antifungal drugs. Rgc1 and Rgc2 are paralogous proteins that regulate the Fps1 glycerol channel in hyperosmotic stress. Hyperosmotic conditions lead Hog1 MAP kinase to phosphorylate Rgc2 and cause its dissociation from Fps1, allowing the channel to close and protect the cell from damage. Rgc2 contains pleckstrin homology (PH) domains broken up by long insertions and more phosphorylation sites than targeted by Hog1 in response to hyperosmotic stress. Since none of the other MAP ki
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"Identification and characterization of YAP1 as a functional oncogene in gastric cancer." Thesis, 2011. http://library.cuhk.edu.hk/record=b6075132.

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Array comparative genomic hybridization (array-CGH) was used in this study to analyze the chromosomal aberrations in 9 gastric cancer cell lines. Our results showed good concordance with those of conventional CGH. We correlated the results from array-CGH with expression profiling and found some novel and independent target genes which deserved further confirmation.<br>Gastric cancer is one of the most common malignancies worldwide and is the second most frequent cause of cancer related death. A variety of genetic and epigenetic aberrations underlie development abnormality of gastric cancer.<br
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Amaral, Catarina Sá Almeida. "Role of Yap8 and Yap1 b-ZIP transcription factors in arsenic stress." Doctoral thesis, 2010. http://hdl.handle.net/10362/14119.

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Arsenic compounds are highly toxic substances; nevertheless they are used in the treatment of acute promyelocytic leukaemia. Therefore it is pressing to gain knowledge on its toxicity and detoxification mechanisms. The cellular entry pathways have been discovered and by transcriptome analysis it is known that arsenic activates the transcription of genes activated by, among others, Rpn4, Met4 and Yap1.(...)<br>Fundação para a Ciência e a Tecnologia
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HUNG, YU-TING, and 洪毓婷. "The Exploration of Obesogenic Environment Change in Taichung City,Yaer 2013~2014." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/37prd2.

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碩士<br>亞洲大學<br>健康產業管理學系健康管理組<br>106<br>Background 　　Obesity has now become one of the issues that need to be addressed by countries around the world. In addition to affecting the quality of life and psychological burden of individuals, obesity can even cause problems in the social and economic losses of the entire family and the country. Many studies have found that overweight and obesity are associated with chronic diseases such as cardiovascular disease, cancer, metabolic syndrome, hypertension, and hyperlipidemia. However, in China, eight of the top ten causes of death in 2017 are highly cor
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Jhih-SinLu and 陸致信. "YAP1 interacts with RUNX3 and enhances radio-sensitivity of non-small cell lung cancer." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/55002575693611991627.

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50

Chih-YiLee and 李芷伊. "The role of Hippo -yes-associated protein 1 (Yap1)/tafazzin (Taz) pathway in adipocyte function." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/6529y5.

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