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Journal articles on the topic 'Α-aminonitriles derivatives'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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1

Gharib, Ali, Nader Noroozi Pesyan, Leila Vojdani Fard та Mina Roshani. "Catalytic Synthesis of α-Aminonitriles Using Nano Copper Ferrite CuFe2O4 under Green Conditions". Organic Chemistry International 2014 (12 березня 2014): 1–8. http://dx.doi.org/10.1155/2014/169803.

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Copper ferrite nanomaterial CuFe2O4 as reusable heterogeneous initiator in the synthesis of α-aminonitriles. The nanocatalyst is easily recovered and its reusability is recorded. Synthesis of α-aminonitriles derivatives by one-pot reaction of different aldehydes with amines and trimethylsilyl cyanides has been developed using nano copper ferrite CuFe2O4 catalyst under room temperature and green solvent (water as solvent) conditions. α-aminonitriles are important in preparing a wide variety of amino acids, amides, diamines, and nitrogen containing heterocycles.
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2

Ghafuri, Hossein, Afsaneh Rashidizadeh, Behnaz Ghorbani та Majid Talebi. "Nano magnetic sulfated zirconia (Fe3O4@ZrO2/SO42−): an efficient solid acid catalyst for the green synthesis of α-aminonitriles and imines". New Journal of Chemistry 39, № 6 (2015): 4821–29. http://dx.doi.org/10.1039/c5nj00314h.

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In this research, nano magnetic sulfated zirconia was prepared through a green and facile method and acted as a novel, heterogeneous, efficient nano-catalyst for the one-pot three component synthesis of α-aminonitrile derivatives.
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3

Rossi, Jean-Christophe, Marc Marull, Nicolas Larcher та ін. "A recyclable chiral auxiliary for the asymmetric syntheses of α-aminonitriles and α-aminophosphinic derivatives". Tetrahedron: Asymmetry 19, № 7 (2008): 876–83. http://dx.doi.org/10.1016/j.tetasy.2008.03.013.

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4

KARIMI-JABERI, Zahed, та Abdolaziz BAHRANI. "One-pot three-component synthesis of α-aminonitriles using sodium dihydrogen phosphate as a catalyst at room temperature". Revue Roumaine de Chimie 65, № 12 (2021): 1093–97. http://dx.doi.org/10.33224/rrch.2020.65.12.04.

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Sodium dihydrogen phosphate was applied as an efficient and inexpensive catalyst for the synthesis of biologically potent α-aminonitrile derivatives through a one-pot three-component reaction of aldehyde, amine and trimethylsilyl cyanide. The reactions were easily carried out under mild, green and eco-friendly conditions in ethanol at room temperature affording high yields of the products in short times.
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5

Ladraa, Souheila, Fabienne Berrée, Abdelmalek Bouraiou та ін. "Efficient synthesis and X-ray structures of new α-quinolin-3-yl-α-aminonitriles and derivatives". Tetrahedron Letters 54, № 8 (2013): 749–52. http://dx.doi.org/10.1016/j.tetlet.2012.11.032.

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6

Ladraa, Souheila, Fabienne Berree, Abdelmalek Bouraiou та ін. "ChemInform Abstract: Efficient Synthesis and X-Ray Structures of New α-Quinolin-3-yl-α-aminonitriles and Derivatives." ChemInform 44, № 23 (2013): no. http://dx.doi.org/10.1002/chin.201323141.

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7

Marco, JoséL, та Simon Ingate. "From α,α-disubstituted α-aminonitriles to heterocycles: Synthesis of derivatives of 4-amino-2,3-dihydroisothiazole 1,1-dioxide, a new heterocyclic ring system". Tetrahedron Letters 38, № 27 (1997): 4835–36. http://dx.doi.org/10.1016/s0040-4039(97)01002-2.

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8

Petride, Horia, Constantin Drăghici, Cristina Florea, and Aurica Petride. "RuO4-mediated oxidation of N-benzylated tertiary amines. 3. Behavior of 1,4-dibenzylpiperazine and its oxygenated derivatives." Open Chemistry 4, no. 4 (2006): 674–94. http://dx.doi.org/10.2478/s11532-006-0039-8.

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Abstract1,4-Dibenzylpiperazine (1),-2-piperazinone (7),-2,6-piperazinedione (9), and 1-benzoyl-4-benzylpiperazine (30) were oxidized by RuO4 (generated in situ) by attack at their endocyclic and exocyclic (i.e., benzylic) aminic N-α-C-H bonds to afford various oxygenated derivatives, including acyclic diformamides, benzaldehyde, and benzoic acid. The reaction outcome was complicated by (i) the hydrolysis of diformamides, occurred during the work-up, and (ii) the reaction of benzaldehyde with the hydrolysis-derived amines giving imidazolidines and/or Schiff bases. Benzoic acid resulted from ben
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9

MARCO, J. L., та S. INGATE. "ChemInform Abstract: From α,α-Disubstituted α-Aminonitriles to Heterocycles: Synthesis of Derivatives of 4-Amino-2,3- dihydroisothiazole 1,1-Dioxide, a New Heterocyclic Ring System." ChemInform 28, № 41 (2010): no. http://dx.doi.org/10.1002/chin.199741161.

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10

Teimouri, A., L. Ghorbanian та A. Moatari. "Application of various types of alumina and nano-γ-alumina sulfuric acid in the synthesis of α-aminonitriles derivatives: comparative study". Bulletin of the Chemical Society of Ethiopia 28, № 3 (2014): 441. http://dx.doi.org/10.4314/bcse.v28i3.13.

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11

Voznesenskaia, Natalia G., Olga I. Shmatova, Anna A. Sosnova та Valentine G. Nenajdenko. "From Cyclic Ketimines to α-Substituted Cyclic Amino Acids and their Derivatives: Influence of Ring Size and Substituents on Stability and Reactivity of Cyclic Aminonitriles". European Journal of Organic Chemistry 2019, № 4 (2018): 625–32. http://dx.doi.org/10.1002/ejoc.201801087.

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12

Mahajan, Suruchi, Pankaj Chauhan, Uğur Kaya, Kristina Deckers, Kari Rissanen та Dieter Enders. "Enantioselective synthesis of pyrazolone α-aminonitrile derivatives via an organocatalytic Strecker reaction". Chemical Communications 53, № 49 (2017): 6633–36. http://dx.doi.org/10.1039/c7cc02874a.

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A highly enantioselective organocatalytic Strecker reaction of pyrazolone-derived ketimines with TMSCN has been developed providing an efficient entry to pyrazolone α-aminonitrile derivatives with a tetra-substituted stereocenter.
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13

Voznesenskaia, Natalia G., Olga I. Shmatova, Anna A. Sosnova та Valentine G. Nenajdenko. "Front Cover: From Cyclic Ketimines to α-Substituted Cyclic Amino Acids and their Derivatives: Influence of Ring Size and Substituents on Stability and Reactivity of Cyclic Aminonitriles (Eur. J. Org. Chem. 4/2019)". European Journal of Organic Chemistry 2019, № 4 (2019): 611. http://dx.doi.org/10.1002/ejoc.201900053.

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14

Paventi, Martino, Francis L. Chubb, and John T. Edward. "Assisted hydrolysis of the nitrile group of 2-aminoadamantane-2-carbonitrile." Canadian Journal of Chemistry 65, no. 9 (1987): 2114–17. http://dx.doi.org/10.1139/v87-351.

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Attempts to hydrolyse the nitrile group of 2-aminoadamantane-2-carbonitrile by mineral acid or alkali have been unsuccessful. However, treatment of the aminonitrile with benzaldehyde in alkaline solution gives the benzal derivative of the α-aminoamide, readily hydrolysed to the α-aminoamide. Alternatively, benzoylation of the amino group followed by acid hydrolysis gives successively the α-benzamido acid and the α-amino acid. Possible mechanisms for these facilitated hydrolyses are advanced.
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15

Declerck, Delphine, Solen Josse, Albert Nguyen Van Nhien, Jan Szymoniak, Philippe Bertus та Denis Postel. "Reactivity of sugar α-aminonitrile derivatives under titanium-mediated cyclopropanation conditions". Tetrahedron 68, № 4 (2012): 1145–52. http://dx.doi.org/10.1016/j.tet.2011.11.067.

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16

Declerck, Delphine, Solen Josse, Albert Nguyen Van Nhien, Jan Szymoniak, Philippe Bertus та Denis Postel. "ChemInform Abstract: Reactivity of Sugar α-Aminonitrile Derivatives under Titanium-Mediated Cyclopropanation Conditions." ChemInform 43, № 27 (2012): no. http://dx.doi.org/10.1002/chin.201227192.

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17

Enders, Dieter, Maurice Hubert Bonten та Gerhard Raabe. "Asymmetric Nucleophilic Glyoxylation through a Metalated α-Aminonitrile Derivative in Michael Additions to Nitroalkenes". Angewandte Chemie International Edition 46, № 13 (2007): 2314–16. http://dx.doi.org/10.1002/anie.200604802.

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18

Yücer, Rümeysa, Rossana Piccinno, Ednah Ooko, Mona Dawood, Gerhard Bringmann, and Thomas Efferth. "Predictive and Prognostic Relevance of ABC Transporters for Resistance to Anthracycline Derivatives." Biomolecules 15, no. 7 (2025): 971. https://doi.org/10.3390/biom15070971.

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Anthracyclines have been clinically well established in cancer chemotherapy for decades. The main limitations of this drug class are the development of resistance and severe side effects. In the present investigation, we analyzed 30 anthracyclines in a panel of 59 cell lines of the National Cancer Institute, USA. The log10IC50 values varied from −10.49 M (3′-deamino-3′-(4″-(3″-cyano)morpholinyl)-doxorubicin, 1) to −4.93 M (N,N-dibenzyldaunorubicin hydrochloride, 30). Multidrug-resistant NCI-ADR-Res ovarian cancer cells revealed a high degree of resistance to established anthracyclines (between
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19

Rakhtshah, Jamshid, Behrouz Shaabani, Sadegh Salehzadeh та Neda Hosseinpour Moghadam. "Synthesis of 1-(α-aminoalkyl)-2-naphthol and α-aminonitrile derivatives with molybdenum Schiff base complex covalently bonded on silica-coated magnetic nanoparticles and DNA interaction study of one type of derivatives using computational and spectroscopic methods". Bioorganic Chemistry 85 (квітень 2019): 420–30. http://dx.doi.org/10.1016/j.bioorg.2019.01.022.

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20

Brahmachari, Goutam, та Bubun Banerjee. "A Comparison Between Catalyst-Free and ZrOCl2⋅8H2O-Catalyzed Strecker Reactions for the Rapid and Solvent-Free One-Pot Synthesis of Racemic α-Aminonitrile Derivatives". Asian Journal of Organic Chemistry 1, № 3 (2012): 251–58. http://dx.doi.org/10.1002/ajoc.201200055.

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21

Rakhtshah, Jamshid, та Sadegh Salehzadeh. "Molybdenum Schiff base complex supported on MNPs as an efficient and easily recyclable catalyst in three-component Strecker reaction for synthesis of α-aminonitrile derivatives". Research on Chemical Intermediates 43, № 12 (2017): 6973–91. http://dx.doi.org/10.1007/s11164-017-3031-3.

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22

Sun, Yurong, Shixiang Hu, Yao Yang, Wenliang Gao та Tao Yang. "Efficient immobilization of sulfonic acid groups in the backbone of aluminoborate-based molecular sieve for the expeditious synthesis of 14-aryl-14H-dibenzo[a,j]xanthene and α-aminonitrile derivatives under solvent-free conditions". Applied Catalysis A: General 699 (червень 2025): 120268. https://doi.org/10.1016/j.apcata.2025.120268.

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23

Abbas, Teimouri, Najafi Chermahini Alireza та Ghorbanian Leila. "Nano-Alumina Sulfuric Acid: An Efficient Catalyst for the Synthesis of α-Aminonitriles Derivatives". 22 липня 2013. https://doi.org/10.5281/zenodo.1087328.

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An efficient and green protocol for the synthesis of α- aminonitriles derivatives by one-pot reaction of different aldehydes with amines and trimethylsilyl cyanides has been developed using natural alumina, alumina sulfuric acid (ASA), nano-γ-alumina, nanoalumina sulfuric acid (nano-ASA) under microwave irradiation and solvent-free conditions. The advantages of methods are short reaction times, high yields, milder conditions and easy work up. The catalysts can be recovered for the subsequent reactions and reused without any appreciable loss of efficiency.
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24

Enders, Dieter, Maurice Hubert Bonten та Gerhard Raabe. "Asymmetric Nucleophilic Glyoxylation Through a Metalated α-Aminonitrile Derivative in Michael Additions to Nitroalkenes." ChemInform 38, № 28 (2007). http://dx.doi.org/10.1002/chin.200728062.

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25

Baghery, Saeed, Mohammad Ali Zolfigol, Maliheh Safaiee, Diego A. Alonso та Abbas Khoshnood. "Novel nano molten salt tetra‐2,3‐pyridiniumporphyrazinato‐oxo‐vanadium tricyanomethanide as a vanadium surface‐free phthalocyanine catalyst: Application to Strecker synthesis of α‐aminonitrile derivatives". Applied Organometallic Chemistry 31, № 11 (2017). http://dx.doi.org/10.1002/aoc.3775.

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26

Sun, Mingzhe, Wei Liu, Wei Wu та ін. "Synthesis and characterization of Pd supported on methane diamine (propyl silane) functionalized Fe3O4 nanoparticles as a magnetic catalyst for synthesis of α-aminonitriles and 2-methoxy-2-phenylacetonitrile derivative via Strecker-type reaction under ambient and solvent-free conditions". Inorganic and Nano-Metal Chemistry, 14 вересня 2021, 1–15. http://dx.doi.org/10.1080/24701556.2021.1977819.

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