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Journal articles on the topic 'Α-bromo derivatives'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Easton, CJ, та SC Peters. "Reactions of α-Substituted Glycine Derivatives With Stannanes in the Presence of Disulfides". Australian Journal of Chemistry 47, № 5 (1994): 859. http://dx.doi.org/10.1071/ch9940859.

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Reactions of α- bromo -, α- benzoyloxy - and α- methoxy -substituted glycine derivatives with stannanes afforded the corresponding α- centred glycinyl radical, which reacted with di -t-butyl disulfide and diphenyl disulfide by homolytic substitution to give the corresponding α-t- butylthio- and α-phenylthio -substituted glycine derivatives, respectively. The glycinyl radical reacted with dibenzyl disulfide by displacement of benzyl radical to give a mixed disulfide, which was subsequently reduced to the corresponding α- benzylthio-substituted glycine derivative. In related reactions of a cysti

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2

Zhu, Rong-Rong, Xi-Qiang Hou та Da-Ming Du. "Synthesis of Benzofuran Derivatives via a DMAP-Mediated Tandem Cyclization Reaction Involving ortho-Hydroxy α-Aminosulfones". Molecules 29, № 16 (2024): 3725. http://dx.doi.org/10.3390/molecules29163725.

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An efficient cascade cyclization strategy was developed to synthesize aminobenzofuran spiroindanone and spirobarbituric acid derivatives utilizing 2-bromo-1,3-indandione, 5-bromo-1,3-dimethylbarbituric acid, and ortho-hydroxy α-aminosulfones as substrates. Under the optimized reaction conditions, the corresponding products were obtained with high efficiency, exceeding 95% and 85% yields for the respective derivatives. This protocol demonstrates exceptional substrate versatility and robust scalability up to the Gram scale, establishing a stable platform for the synthesis of 3-aminobenzofuran de

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3

Hřebabecký, Hubert, та Antonín Holý. "Synthesis of Deoxy, Dideoxy and Didehydrodideoxy Analogs of 9-(4-C-Hydroxymethyl-α-L-pentofuranosyl)adenine". Collection of Czechoslovak Chemical Communications 59, № 7 (1994): 1654–64. http://dx.doi.org/10.1135/cccc19941654.

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Condensation of 1,2-di-O-acetyl-3,5-di-O-benzoyl-4-C-benzoyloxymethyl-L-arabinofuranose with N6-benzoyladenine, catalyzed with tin tetrachloride, afforded nucleoside I, which upon partial deacetylation and subsequent mesylation was converted into 9-(3,5-di-O-benzoyl-4-C-benzoyloxymethyl-2-O-methanesulfonyl-α-L-arabinofuranosyl)adenine (III). 9-(2,5,6-Tri-O-acetyl-4-C-acetoxymethyl-3-O-methanesulfonyl-α-L-arabinofuranosyl)-N6-benzoyladenine (V) was obtained by condensation of 1,2,5-tri-O-acetyl-4-C-acetoxymethyl-3-O-methanesulfonyl-L-arabinose with N6-benzoyladenine. Reaction of mesyl derivativ

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4

U., C. Mashelkar, and A. Audi A. "Synthesis of some novel 4-substituted coumarins having antibacterial activity (Part-I)." Journal of Indian Chemical Society Vol. 82, Mar 2005 (2005): 254–57. https://doi.org/10.5281/zenodo.5827011.

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Organic Research Laboratory. SS & LS Patkar College, Goregaon (W). Mumbai-400 062, India E-mail: ajayaaudi@rediffmail.com                                                        Fax : 91-22-28744755 <em>Manuscript received 13 February 2004, revised 1 September 2004, accepted 24 November 2004</em> Methyl coumarin-4-methyl acetate on bromination in dioxane or dichloroethane as solvent resulted in sidechain bromination giving a-bromo derivative. The same r

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5

Ding, Ran, Zhi-Dao Huang, Zheng-Li Liu, Tian-Xiang Wang, Yun-He Xu та Teck-Peng Loh. "Palladium-catalyzed cross-coupling of enamides with sterically hindered α-bromocarbonyls". Chemical Communications 52, № 32 (2016): 5617–20. http://dx.doi.org/10.1039/c5cc10653b.

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Palladium-catalyzed intermolecular alkylation of enamides with α-bromo carbonyls was developed. Under mild reaction conditions, various cyclic and acyclic enamides reacted well with α-bromo carbonyls to afford the corresponding multi-substituted alkene products in good yields. The coupling products could be converted into very useful γ-amino acid, δ-amino alcohol, 1,4-dicarbonyl and γ-lactam derivatives.

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6

Kirihara, Masayuki, Tomofumi Takuwa, Maiko Okumura та ін. "ChemInform Abstract: α-Bromo-α,α-difluoroallyl Derivatives as Synthetic Intermediate: Nucleophilic Substitution of α-Bromo-α,α-difluoroallyl Derivatives in the Presence of Palladium Catalysts." ChemInform 31, № 50 (2000): no. http://dx.doi.org/10.1002/chin.200050029.

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7

Glisin, Djordje, Olga Jovanovic, Gordana Stojanovic та ін. "Synthesis of methyl 3,4-anhydro-6-bromo-2-o-tert-butyldimethylsilyl-6-deoxy-α-d-allopyranoside from α-d-glucose". Journal of the Serbian Chemical Society, № 00 (2024): 49. http://dx.doi.org/10.2298/jsc230831049g.

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Some of simple carbohydrates and their derivatives are used clinically for the treatment of various diseases. Epoxide derivatives, which can be obtained by the intramolecular elimination of water from two vicinal hydroxyl groups, are stable, but sufficiently reactive compounds very often used as intermediaries in various syntheses. Synthesis of epoxide derivative, methyl 3,4-anhydro-6- bromo-2-O-tert-butyldimethylsilyl-6-deoxy-?-D-allopyranoside from ?-D-glucose was achieved in high yields in the minimal number of synthetic steps. Anhydrous glucose was used as a starting material which was tra

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8

Tsuchiya, Yuto, Ryota Onai, Daisuke Uraguchi та Takashi Ooi. "Redox-regulated divergence in photocatalytic addition of α-nitro alkyl radicals to styrenes". Chemical Communications 56, № 75 (2020): 11014–17. http://dx.doi.org/10.1039/d0cc04821f.

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9

Magwaza, Nontokozo M., Garland K. More, Samantha Gildenhuys та Malose J. Mphahlele. "In Vitro α-Glucosidase and α-Amylase Inhibition, Cytotoxicity and Free Radical Scavenging Profiling of the 6-Halogeno and Mixed 6,8-Dihalogenated 2-Aryl-4-methyl-1,2-dihydroquinazoline 3-Oxides". Antioxidants 12, № 11 (2023): 1971. http://dx.doi.org/10.3390/antiox12111971.

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Series of the 6-bromo/iodo substituted 2-aryl-4-methyl-1,2-dihydroquinazoline-3-oxides and their mixed 6,8-dihalogenated (Br/I and I/Br) derivatives were evaluated for inhibitory properties against α-glucosidase and/or α-amylase activities and for cytotoxicity against breast (MCF-7) and lung (A549) cancer cell lines. The 6-bromo-2-phenyl substituted 3a and its corresponding 6-bromo-8-iodo-2-phenyl-substituted derivative 3i exhibited dual activity against α-glucosidase (IC50 = 1.08 ± 0.02 μM and 1.01 ± 0.05 μM, respectively) and α-amylase (IC50 = 5.33 ± 0.01 μM and 1.18 ± 0.06 μM, respectively)

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10

Mishra, Ashish A., та Bhalchandra M. Bhanage. "Ru-Tethered (R,R)-TsDPEN with DMAB as an efficient catalytic system for high enantioselective one-pot synthesis of chiral β-aminol via asymmetric transfer hydrogenation". New Journal of Chemistry 45, № 12 (2021): 5357–62. http://dx.doi.org/10.1039/d0nj06108e.

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This work reflects Ru-tethered-TsDPEN as an active chiral catalyst for one pot selective synthesis of optically active α-substituted alcohols and its derivatives from α-bromo ketones in the presence of dimethylamine borane (DMAB) as the hydrogen source.

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11

Klemm, D., та G. Geschwend. "α-Bromo-α-ethoxy-acetic Acid Derivatives as New Alkylating Reagents". Synthetic Communications 16, № 11 (1986): 1431–38. http://dx.doi.org/10.1080/00397918608056392.

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12

Shaw, Joanne P., та Eng Wui Tan. "Selective Bromination of α-Chloro and α-Bromo Carboxylic Acid Derivatives". Journal of Organic Chemistry 61, № 16 (1996): 5635–37. http://dx.doi.org/10.1021/jo960311l.

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13

Vašš, František, and Jozef Lustoň. "Functional Derivatives of Sterically Hindered Amines. Polyalkylpiperidine Diesters." Collection of Czechoslovak Chemical Communications 60, no. 9 (1995): 1529–35. http://dx.doi.org/10.1135/cccc19951529.

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Several diesters of dicarboxylic acids with pendant polyalkylpiperidine structural units were prepared from α-bromo and α,α'-dibromo substituted aliphatic dicarboxylic acid diesters by a nucleophilic replacement reaction with 2,2,6,6-tetramethyl-4-hydroxypiperidine, 1,2,2,6,6-pentamethyl-4-hydroxypiperidine, and 2,2,6,6-tetramethyl-4-aminopiperidine, by a nucleophilic addition of amino derivative to the α,β-unsaturated dicarboxylic acid diester and by an acid catalyzed condensation of 2,2,6,6-tetramethyl-4-oxopiperidine with diethyl bis(hydroxymethyl)malonate.

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14

Song, Jiao, Wenbo Chen, Yunjie Zhao, Chenglong Li, Guang Liang та Lehao Huang. "Palladium-catalyzed ortho C–H bond alkylation of benzylamides with α-bromo ketones". RSC Advances 6, № 60 (2016): 54984–92. http://dx.doi.org/10.1039/c6ra07450b.

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A Pd-catalyzed alkylation of ortho C–H bonds in benzylamides with α-bromo ketones or nitrile is reported. Furthermore, a straightforward strategy for preparing 3-arylisoquinoline derivatives is developed.

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15

Ivanchenko, D. G. "Synthesis and physical-chemical properties of 8-bromo-3-methyl-7-α-methylbenzylxanthine derivatives". Farmatsevtychnyi zhurnal, № 2 (14 серпня 2018): 37–42. http://dx.doi.org/10.32352/0367-3057.2.16.01.

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The level of modern pharmaceutical science development is determined by the introduction in medical practice of new effective and non-toxic drugs. The problem of new drugs search depends on the presence in the arsenal of pharmacologists significant amount of original and promising bioactive compounds. In this aspect a special role is given to synthetic compounds of natural origin, which are successfully used in medical practice. Recent researches of national and foreign scientists suggest significant perspective synthetic xanthine derivatives in the creation of new drugs with various effects.&

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16

Siddiqui, Salimuzzaman, Bina S. Siddiqui, and Sabira Begum. "Reaction of Harmidine/Harmaline with BrCN — a Facile Mono- and Di-Bromination at a-Carbon of the Imine Tautomer." Zeitschrift für Naturforschung B 40, no. 12 (1985): 1747–48. http://dx.doi.org/10.1515/znb-1985-1225.

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Abstract Reaction of harmidine/harmaline with BrCN has afforded mono- and di-bromo derivatives I and II respectively indicating the substitution of bromine at the α-carbon of imine through its enamine tautomer

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17

Farat, Oleg, Svetlana Varenichenko, Victor Markov, and Karolina Yanova. "IN SILICO PREDICTION OF BIOLOGICAL ACTIVITY OF BROMO DERIVATIVES OF HYDROACRIDINES." Ukrainian Chemistry Journal 89, no. 6 (2023): 97–110. http://dx.doi.org/10.33609/2708-129x.89.06.2023.97-110.

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The aim of the work was to establish the spectrum of biological activity of new derivatives of 9-bromo-1,2,3,4-tetrahydroacridine due to the limited amount of literature data. In silico prediction of selected bromo-derivatives of hydrogenated acridines was performed using the SuperPred 3.0 web resource. The obtained results were compared with the results of prediction of active drugs that contain the acridine cycle in their structure - Tacrine, Amiridine and Amsacrine. Results ≤80% were taken into account. The most promising compound was 9-bromo-1,2,3,4-tetrahydroacridine. A common predict

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18

Krebs, HD. "Thienoisothiazoles. III. The Synthesis and Reactions of 3-Phenyl-5-alkylthioisothiazole-4-carbonitriles and 3-Phenylthieno[3,2-d]isothiazoles." Australian Journal of Chemistry 42, no. 8 (1989): 1291. http://dx.doi.org/10.1071/ch9891291.

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Oxidation of the alkyl 3-amino-4-cyano-3-phenylpropenedithioates (1), obtained by alkylation of the condensation product of 3-amino-3-phenylpropenenitrile and carbon disulfide, produced 3-phenyl-5-alkylthioisothiazole-4-carbonitriles (2a-d). The ease of nucleophilic displacement of the S-alkyl group in the isothiazole (2a) was utilized to synthesize the isothiazoles (2f-j). 3-Phenylthieno[3,2-d] isothiazole (3e) was prepared by deamination, hydrolysis and decarboxylation of the intermediate ethyl 4-amino-3-phenylthieno[3,2-d]isothiazole-5-carboxylate (3a), which was obtained by ring-closure of

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19

Bakthadoss, Manickam, Jayakumar Srinivasan, and Raman Selvakumar. "A Simple and Direct Synthesis of 3-Methylene-1, 4-diarylazetidin-2-ones and (E)-3-Arylidene-1-phenylazetidin-2-ones Using Baylis–Hillman Derivatives." Australian Journal of Chemistry 67, no. 2 (2014): 295. http://dx.doi.org/10.1071/ch13382.

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Herein we describe a direct method, promoted by potassium tert-butoxide (KOtBu), for the synthesis of highly substituted α-methylene β-lactams and α-arylidene β-lactams from the amino ester intermediates derived from the acetates and bromo derivatives of the Baylis–Hillman adducts. A variety of β-lactams was synthesized in a single step with good yields.

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20

Pham, Phuong-Truc T., та Mamoun M. Bader. "α-Halogenated Curcumins". Crystals 14, № 12 (2024): 1041. https://doi.org/10.3390/cryst14121041.

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α- or 4-Substituted curcumin analogues are scarce. We describe herein the syntheses and crystal structures of the first α-halogenated curcumin derivatives: (1E,6E)-1,7-bis (4-hydroxy-3-methoxyphenyl)-4-bromo-5-hydroxy-1,3,6-heptatriene-3-one or (4-bromocurcumin) (1) and (1E,6E)-1,7-bis (4-hydroxy-3-methoxyphenyl)-4-chloro-5-hydroxy-1,3,6-heptatriene-3-one or (4-chlorocurcumin) (2). We note that the key step in the successful synthesis of the bromo-analog is the use of slightly acidic media to favor the diketo form of curcumin prior to carrying out the reaction. Both newly prepared compounds as

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21

Lorion, Mélanie M., Vanessa Koch, Martin Nieger та ін. "Cobalt‐Catalyzed α‐Arylation of Substituted α‐Bromo α‐Fluoro β‐Lactams with Diaryl Zinc Reagents: Generalization to Functionalized Bromo Derivatives". Chemistry – A European Journal 26, № 58 (2020): 13163–69. http://dx.doi.org/10.1002/chem.202001721.

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22

Mphahlele, Malose J., and Temitope O. Olomola. "Synthesis and Transformation of 5-Acetyl-2-aryl-6-hydroxybenzofurans into Furanoflavanone Derivatives." Synthesis 51, no. 18 (2019): 3431–42. http://dx.doi.org/10.1055/s-0039-1690001.

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Tandem palladium-catalyzed Sonogashira cross-coupling and heteroannulation of 3-bromo-2,4-dihydroxy-5-iodoacetophenone with arylacetylenes followed by the base-mediated Claisen–Schmidt aldol condensation of the intermediate 5-acetyl-2-aryl-7-bromo-6-hydroxybenzofurans with benzaldehyde derivatives afforded the corresponding linear 2-arylbenzofuranchalcone hybrids. The presence of the o-hydroxy-trans-α,β-unsaturated carbonyl moiety in the prepared furanochalcone hybrids facilitated acid-mediated cycloisomerization into the corresponding linear furanoflavanones. The structures of the prepared co

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23

Mikhailov, Sergei N., Nelly Sh Padyukova, Marat Ya Karpeiskii, Lidiya I. Kolobushkina, and Leon N. Beigelman. "Use of 5-deoxy-ribo-hexofuranose derivatives for the preparation of 5'-nucleotide phosphonates and homoribonucleosides." Collection of Czechoslovak Chemical Communications 54, no. 4 (1989): 1055–66. http://dx.doi.org/10.1135/cccc19891055.

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A convenient and general method is proposed for the synthesis of 5'-nucleotide phosphonate analogs starting from 5-deoxy-1,2-O-isopropylidene-α-D-xylo-hexofuranose which can easily be produced in preparative quantities from D-glucose. Phosphonate IIIe was synthesized by means of the Arbuzov reaction between 3-O-benzoyl-6-bromo-5,6-dideoxy-1,2-O-isopropylidene-α-D-ribo-hexofuranose and triethyl phosphite. The consecutive acetolysis, condensation with uracil and N6-benzoyladenine bis-trimethylsilyl derivatives and deblocking possessed phosphonate analogs of 5'-nucleotides in good yields. The int

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24

SHAW, J. P., та E. W. TAN. "ChemInform Abstract: Selective Bromination of α-Chloro and α-Bromo Carboxylic Acid Derivatives." ChemInform 27, № 49 (2010): no. http://dx.doi.org/10.1002/chin.199649081.

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25

Hřebabecký, Hubert, та Antonín Holý. "Synthesis of 1-(3-Azido-2,3-dideoxy-4-C-hydroxymethyl-α-L-threo-pentofuranosyl)thymine, 1-(2,3-Dideoxy-4-C-hydroxymethyl-α-L-glycero-pentofuranosyl)thymine and 1-(2,3-Dideoxy-4-C-hydroxymethyl-α-L-glycero-pent-2-enofuranosyl)thymine". Collection of Czechoslovak Chemical Communications 58, № 2 (1993): 409–20. http://dx.doi.org/10.1135/cccc19930409.

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1-(2-O-Acetyl-3,5-di-O-benzoyl-4-C-benzoyloxymethyl-α-L-arabinofuranosyl)thymine (II) was converted to 2,2'-anhydro derivative V by selective deacetylation, mesylation and treatment with 1,8-diazabicyclo[5.4.0]undec-7-ene. Cleavage of 2,2'-anhydro ring in compound V with hydrogen chloride or bromide afforded the respective 2'-chloro and 2'-bromo derivatives VI and VII. Reaction of compound VII with Cu/Zn couple and subsequent debenzoylation led to 1-(2,3-dideoxy-4-C-hydroxymethyl-α-L-pent-2-enofuranosyl)thymine (IX). Catalytic hydrogenation of IX gave 1-(2,3-dideoxy-4-C-hydroxymethyl-α-L-glyce

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26

Dolati, Fatemeh, Sayyed Faramarz Tayyari, Mohammad Vakili та Ali Ebrahimi. "Vibrational spectra of α-bromo and α-chloro derivatives of tris(acetylacetonato)chromium(III)". Journal of Molecular Structure 1103 (січень 2016): 1–8. http://dx.doi.org/10.1016/j.molstruc.2015.09.012.

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27

Cheng, Yi-Chen, Ying-Yu Chen та Che-Ping Chuang. "Cobalt salt-catalyzed carbocyclization reactions of α-bromo-N-phenylacetamide derivatives". Organic & Biomolecular Chemistry 15, № 9 (2017): 2020–32. http://dx.doi.org/10.1039/c7ob00009j.

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28

García, Hermenegildo, Roberto Martínez-Utrilla та Miguel A. Miranda. "Photolysis of enol acetates and α-bromo derivatives ofo-(acyloxy)acetophenones". Liebigs Annalen der Chemie 1985, № 3 (1985): 589–98. http://dx.doi.org/10.1002/jlac.198519850320.

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29

Holota, Serhii, Halyna Derkach, Olha Antoniv, et al. "Study of 1,2,4-triazole-3(5)-thiol Behavior in Reactions with 1-phenyl-1H-pyrrole-2,5-dione Derivatives and 3-bromodihydrofuran-2(3H)-one and Antimicrobial Activity of Products." Chemistry Proceedings 3, no. 1 (2020): 68. http://dx.doi.org/10.3390/ecsoc-24-08419.

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In present work we report our studies of the interaction of 1-phenyl-1H-pyrrole-2,5-dione derivatives (N-arylmaleimides) and 3-bromodihydrofuran-2(3H)-one (α-bromo-γ-butyrolactone) as possible [C2]2+ synthons with 1,2,4-triazole-3(5)-thiole targeting on synthesis of novel 5-substituted thiazolo[3,2-b][1,2,4]triazole-6(5H)-ones. According to obtained results was establish that in above-mentioned interactions (conditions: convenient heating, range of solvents/reaction time) the thiol-ene click (for N-arylmaleimides) and SN (for α-bromo-γ-butyrolactone) processes take place, but not [2+3]-cycloco

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30

Faizullina, L. Kh, M. G. Safarov, L. V. Spirikhin, V. S. Kolosnitsyn, Yu A. Kondrova та F. A. Valeev. "Reaction of nitroalkanes with levoglucosenone and its α-bromo and α-iodo derivatives. Cyclopentaannulation of α-halocyclenones". Russian Journal of Organic Chemistry 47, № 6 (2011): 914–19. http://dx.doi.org/10.1134/s1070428011060145.

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31

Pattison, Graham. "Conformational preferences of α-fluoroketones may influence their reactivity". Beilstein Journal of Organic Chemistry 13 (29 грудня 2017): 2915–21. http://dx.doi.org/10.3762/bjoc.13.284.

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Fluorine has been shown in many cases to impart specific and predictable effects on molecular conformation. Here it is shown that these conformational effects may have an influence on reactivity through studying the relative reactivity of various α-halogenated ketones towards borohydride reduction. These results demonstrate that the α-fluoro ketones are in fact a little less reactive than the corresponding α-chloro and α-bromo derivatives. It is suggested, supported by computation, that this effect is due to reactive conformations in which the C–X bond is orthogonal to the carbonyl group for g

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32

Ward, By Robert S., Andrew Pelter, Dominique Goubet та Martyn C. Pritchard. "Diastereoselective synthesis of α-bromo amides leading to diastereomerically enriched α-amino-, α-hydroxy- and α-thiocarboxylic acid derivatives". Tetrahedron: Asymmetry 6, № 2 (1995): 469–98. http://dx.doi.org/10.1016/0957-4166(95)00032-k.

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33

Marques, Carolina, Anthony Burke та Simon Lawrence. "Pd-Catalyzed One-Pot Borylation/Intramolecular Asymmetric Arylation on α-Ketiminoamides: Innovative Approach to Chiral 3-Amino-2-oxindoles". Synlett 29, № 04 (2017): 497–502. http://dx.doi.org/10.1055/s-0036-1590940.

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3-Amino-2-oxindole derivatives are a common framework found in many natural products and medicinal compounds and thus their synthesis is of significant importance. We report for the first time a one-pot approach for the synthesis of these compounds, using a borylation/intramolecular asymmetric arylation sequence starting from ortho-bromo-α-ketimino amide derivatives. Pd(OAc)2 was used as the pre-catalyst along with (R)-BINAP as the chiral source. We successfully obtained a family of 3-phenyl-3-(aryl-amino)-indolin-2-one derivatives (11 in total) with excellent yields (up to 98%) and enantios

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34

Saddique, Furqan Ahmad, Matloob Ahmad, Usman Ali Ashfaq, Muhammad Muddassar, Sadia Sultan та Magdi E. A. Zaki. "Identification of Cyclic Sulfonamides with an N-Arylacetamide Group as α-Glucosidase and α-Amylase Inhibitors: Biological Evaluation and Molecular Modeling". Pharmaceuticals 15, № 1 (2022): 106. http://dx.doi.org/10.3390/ph15010106.

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Diabetes mellitus (DM), a complicated metabolic disorder, is due to insensitivity to insulin function or reduction in insulin secretion, which results in postprandial hyperglycemia. α-Glucosidase inhibitors (AGIs) and α-amylase inhibitors (AAIs) block the function of digestive enzymes, which delays the carbohydrate hydrolysis process and ultimately helps to control the postprandial hyperglycemia. Diversified 2-(3-(3-methoxybenzoyl)-4-hydroxy-1,1-dioxido-2H-benzo[e][1,2]thiazin-2-yl)-N-arylacetamides were synthesized and evaluated for their in vitro inhibitory potential against α-glucosidase an

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35

Faizullina, L. Kh, M. G. Safarov, L. V. Spirikhin, V. S. Kolosnitsyn, Yu A. Kondrova та F. A. Valeev. "ChemInform Abstract: Reaction of Nitroalkanes with Levoglucosenone and Its α-Bromo and α-Iodo Derivatives. Cyclopentaannulation of α-Halocyclenones." ChemInform 42, № 51 (2011): no. http://dx.doi.org/10.1002/chin.201151124.

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36

Hasan, Sara, та Muheb A. Sadaldin. "Synthesis of N,N-Substituted-Propargylaniline Derivatives by Coupling Reaction between N-aryl Propargylamine and α-Bromo Carbonyl Compounds". Zanin Journal of Science and Engineering 1, № 1 (2025): 33–53. https://doi.org/10.64362/zjse.33.

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Due to its importance propargylamine and its derivatives have been a place of interest to our team. Ten new derivatives of propargylamine have been synthesized and then characterized by 1H NMR and 13C NMR. The synthesis process was carried out in three steps: Firstly, aniline and its derivatives were propargylated. Secondly, bromination of acetophenone and its derivatives was carried out. And lastly, the products of the previous two reactions were reacted in mild conditions and a mechanism of action is suggested.

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37

Boyes, Scott A., та Alan T. Hewson. "Enantioselective synthesis of α-bromo acid derivatives and bromohydrins † from tartrate derived bromoacetals". Journal of the Chemical Society, Perkin Transactions 1, № 16 (2000): 2759–65. http://dx.doi.org/10.1039/b002106g.

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38

Hankovszky, H. Olga, Kálmán Hideg, M. Judit Lovas, et al. "Synthesis and reaction of ortho-fluoronitroaryl nitroxides. Novel versatile synthons and reagents for spin-labelling studies." Canadian Journal of Chemistry 67, no. 9 (1989): 1392–400. http://dx.doi.org/10.1139/v89-214.

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2-Flurophenyl- and 2,5-bis(fluorophenyl)pyrrolidin-1-oxyls (2 and 6) were synthesized from the corresponding nitrones 1,4, and 5 with the Grignard reagent prepared from 1-bromo-4-fluorobenzene. The reaction of 2,2,5,5-tetramethyl-3-formyl-3-pyrrolin-1-oxyl (8) with (4-FC6H4)2Cd gave 2,2,5,5-tetramethyl-3-(α-hydroxy-4-fluorobenzyl)-3-pyrrolin-1-oxyl (9), which was oxidized with MnO2 to 2,2,5,5-tetramethyl-3-(4-fluorobenzoyl)-3-pyrrolin-1-oxyl (10). The aryl nitroxides 2, 6, and 10 were nitrated with concentrated H2SO4/HNO3 to ortho-fluoronitrophenyl compounds 3, 7, and 11. The fluoro nitro deri

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39

Duty, Ryan, and Christopher E. Hobbs. "Post-Polymerization Modification of Ring Opening Metathesis Polymerization (ROMP)-Derived Materials Using Wittig Reactions." Polymers 12, no. 6 (2020): 1247. http://dx.doi.org/10.3390/polym12061247.

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This communication describes our recent efforts to utilize Wittig olefination reactions for the post-polymerization modification of polynorbornene derivatives prepared through ring opening metathesis polymerization (ROMP). Polymerizing α-bromo ester-containing norbornenes provides polymers that can undergo facile substitution with triphenylphosphine. The resulting polymeric phosphonium salt is then deprotonated to form an ylide that undergoes reaction with various aryl aldehydes in a one-pot fashion to yield the respective cinnamates. These materials can undergo further modification through ph

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40

Youk, Eunjee, Wongi Park та Yong Sun Park. "Asymmetric Synthesis of Both Diastereomers of α,α′-disubstituted Iminodiacetic Acid Derivatives Using Stereoselective Nucleophilic Substitution of α-Bromo Esters". Bulletin of the Korean Chemical Society 39, № 5 (2018): 675–78. http://dx.doi.org/10.1002/bkcs.11446.

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41

Norman, Rebecca E., Michael V. Perkins, Andris J. Liepa, and Craig L. Francis. "N,N-Dialkyl-N′-Chlorosulfonyl Chloroformamidines in Heterocyclic Synthesis. Part XI. Some Substitution Reactions of Pyrazolo[1,5-b][1,2,4,6]thiatriazine 1,1-Dioxides." Australian Journal of Chemistry 68, no. 7 (2015): 1011. http://dx.doi.org/10.1071/ch14547.

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The recently discovered pyrazolo[1,5-b][1,2,4,6]thiatriazine template was shown to possess four nucleophilic sites (N2, N4, C5, N7) that underwent a range of substitution reactions. Methylation occurred at both N4 and N7. Alkylation with benzylic halides occurred preferentially at N7, regardless of the solvent, but also occurred at C5, N4, and N2. Similar alkylation with α-halo esters occurred at both N4 and N7, but the latter derivatives underwent a novel pyrazole ring expansion to afford pyrimido[1,6-b][1,2,4,6]thiatriazine derivatives. Bromination of pyrazolo[1,5-b][1,2,4,6]thiatriazines af

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42

Abdel-Megeed, Mohamed F., Mohamed A. Saleh, Mohamed A. Abdo, and Gamal A. El-Hiti. "Reaction of 6-Substituted 3-Amino-2-phenyl-4(3H)- Quinazolinones with D-Ribose and L-Arabinose." Collection of Czechoslovak Chemical Communications 60, no. 6 (1995): 1016–25. http://dx.doi.org/10.1135/cccc19951016.

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Condensation of 3-amino-2-phenyl-4(3H)-quinazolinone (Ia) and 3-amino-6-bromo-2-phenyl-4(3H)-quinazolinone (Ib) with D-ribose and L-arabinose in boiling methanol gave the corresponding N-glycosides IIa, IIIa, IIb and IIIb. Acetylation of compounds II and III, followed by Zemplen's deacetylation, afforded the N-acetyl derivatives VIa, VIb, VIIa and VIIb. According to their NMR spectra in solution, the N-ribosides exist as β-pyranosides in the 4C1 (D) conformation whereas the N-arabinosides are α-pyranosides in the 4C1 (L) conformation.

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43

Rasmia M. Rumez. "Synthesis and Characterization of New Oxazepines Compounds Derived From D- Galactose." journal of the college of basic education 21, no. 87 (2022): 149–57. http://dx.doi.org/10.35950/cbej.v21i87.8861.

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New Schiff bases derived from D-galactose were synthesized by condensation of aldehyde (1,2:3,4-Di-O-isopropylidene-6-carboxaldehyde-α-D-galactopyranose) with different aromatic amines such as (4-bromo, 3-hydroxy, 4-iodo, 4-methoxy) aniline in dry benzene using glacial acetic acid as a catalyst. These compounds were converted to oxazepine derivatives by addition reaction with maleic anhydride in dry benzene as a solvent. The structures of the synthesized compounds have been characterized by elemental analysis, FTIR spectra, some of them by using 1HNMR spectra and measurement of its physi

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44

Kim, Yelim, Kon Ji Park, Yun Soo Choi, Myung-Su Lee та Yong Sun Park. "L-Lactate-mediated Dynamic Kinetic Resolution of α-Bromo Esters for Asymmetric Syntheses of α-Amino Acid Derivatives". Bulletin of the Korean Chemical Society 34, № 8 (2013): 2531–34. http://dx.doi.org/10.5012/bkcs.2013.34.8.2531.

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45

Nam, Jiyoun, Sang-kuk Lee, Kee Yong Kim та Yong Sun Park. "Asymmetric syntheses of α-mercapto carboxylic acid derivatives by dynamic resolution of N-methyl pseudoephedrine α-bromo esters". Tetrahedron Letters 43, № 46 (2002): 8253–55. http://dx.doi.org/10.1016/s0040-4039(02)02020-8.

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46

Nam, Jiyoun, Sang-kuk Lee та Yong Sun Park. "Dynamic thermodynamic resolution of N-methylpseudoephedrine α-bromo esters for asymmetric syntheses of α-hydroxy carboxylic acid derivatives". Tetrahedron 59, № 14 (2003): 2397–401. http://dx.doi.org/10.1016/s0040-4020(03)00285-0.

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47

Skelton, Brian W., Robert V. Stick, Keith A. Stubbs, Andrew G. Watts, and Allan H. White. "The Fluorination (at C5) of Some Derivatives of D-Glucose." Australian Journal of Chemistry 57, no. 4 (2004): 345. http://dx.doi.org/10.1071/ch03288.

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The photobromination of various per-esters of β-D-glucopyranose and α- and β-D-glucopyranosyl fluoride has yielded 5-bromo derivatives capable of conversion into the corresponding 5-fluorides. The best reagent for this conversion was found to be silver tetrafluoroborate in ether/dichloromethane. The single-crystal X-ray structure determination of penta-O-benzoyl-5-fluoro-α-L-idopyranose is presented.As well, various approaches to 5-fluoro glycopyranosides have been developed. The photobromination of phenyl tetra-O-acetyl-β-D-glucopyranoside, followed by fluorination and protecting group remova

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48

Cun, Wendy Y., Paul A. Keller та Stephen G. Pyne. "Synthesis of 7α-Methoxy-7-(4-phenyl-1H-1,2,3-triazol-1-yl)acetamino-3′-arylthio-cephalosporic Acid Derivatives from 7-Aminocephalosporic Acid". Molecules 28, № 21 (2023): 7338. http://dx.doi.org/10.3390/molecules28217338.

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The aim of this project was to develop a synthetic protocol for the preparation of a cephamycin scaffold that would readily allow the synthesis of its analogues with variations at the C-7 amino group and the C-3′ position. We also aimed to develop a method that avoided the use of toxic and potentially explosive diphenyldiazomethane. These aims were achieved via the synthesis of the novel α-bromo acetamide 18 which allowed functionalization at the α-bromo acetamide position by azide and then the introduction of a 4-phenyl-1H-1,2,3-triazol-1-yl moiety via a Cu(I)-catalysed azide–alkyne cycloaddi

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49

Becker, Lisa F., Dennis H. Schwarz, and Gerhard Wenz. "Synthesis of uniform cyclodextrin thioethers to transport hydrophobic drugs." Beilstein Journal of Organic Chemistry 10 (December 9, 2014): 2920–27. http://dx.doi.org/10.3762/bjoc.10.310.

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Methyl and ethyl thioether groups were introduced at all primary positions of α-, β-, and γ-cyclodextrin by nucleophilic displacement reactions starting from the corresponding per-(6-deoxy-6-bromo)cyclodextrins. Further modification of all 2-OH positions by etherification with iodo terminated triethylene glycol monomethyl ether (and tetraethylene glycol monomethyl ether, respectively) furnished water-soluble hosts. Especially the β-cyclodextrin derivatives exhibit very high binding potentials towards the anaesthetic drugs sevoflurane and halothane. Since the resulting inclusion compounds are h

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50

Jabbour, Adel, Reem Smoum, Khuloud Takrouri, et al. "Pharmacologically active boranes." Pure and Applied Chemistry 78, no. 7 (2006): 1425–53. http://dx.doi.org/10.1351/pac200678071425.

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Novel methods are described for the preparation of alkyldimethylamine cyanoboranes and β-hydroxylalkyldimethylamine cyanoboranes by C-lithiation of trimethylamine cyanoboranes followed by reaction with alkyl halides, aldehydes, and ketones. Lithiation of the monobromo derivatives of amine cyanoboranes led to the synthesis of the first examples of diborane derivatives of amine cyanoboranes. Bromo derivatives of amine cyanoboranes and amine carboxyboranes have been synthesized by new simple and efficient methods. Amine fluorocyanoboranes and amine fluorocarboxyboranes, new classes of compounds,

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