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Dissertations / Theses on the topic 'Α-crystallin'

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Published: 4 June 2021
Last updated: 24 July 2025

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1

Knight, Grady C. "The molecular chaperone α-crystallin protects proteins from UV-induced aggregation". Diss., Georgia Institute of Technology, 1999. http://hdl.handle.net/1853/30486.

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2

Muir, Matthew Stewart. "Proteomics of the ovine cataract." Diss., Lincoln University, 2008. http://hdl.handle.net/10182/792.

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The lens of the eye needs to be completely transparent in order to allow all light entering the eye to reach the retina. This transparency is maintained by the highly ordered structure of the lens proteins the crystallins. Any disruption to the lens proteins can cause an opacity to develop which is known as cataract. During cortical cataract formation there is increased truncation of the lens crystallins. It is believed that overactivation of calcium-dependent cysteine proteases, the calpains, is responsible for the increased proteolysis of the crystallins seen during cataractogenesis. Within
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3

Al, Hashmi Salim M. "Studies on the stress responses of M. tuberculosis : tmRNA and α-crystallins". Thesis, University of Surrey, 2016. http://epubs.surrey.ac.uk/811054/.

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Mycobacterium tuberculosis remains a major human health problem killing millions of people around the world. Therefore, the need for an in depth understanding of its pathogenicity is very important to enable rational development of new control strategies.  Not all M. tuberculosis infected individuals progress to active disease at the time of primary infection as some carry an asymptomatic persistent infection that may reactivate later in life to cause disease. Despite a great deal of M. tuberculosis research, the ability of M. tuberculosis to cause long-term persistent infection in immune-comp
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4

SHEN, WEI-TING, та 沈蔚婷. "The stability of the α-crystallin". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/78rsjg.

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碩士<br>國防醫學院<br>生物化學研究所<br>102<br>The lenticular α-crystallin consisits of two 20-kDa polypeptide chains, αA andαB, which belongs to the small heat shock protein family. They have 57% sequence homology among themselves. In this study, the change in structure, chaperone activity, complex size and thermostability of αA and αB- homooligomer and their heterooligomer in different ratio incubated at 37℃ were investigated. The result showed that heterooligomer of αA and αB-crystallin have about 29% smaller than αB-homooligomer in exposed hydrophobic region as measured by ANS binding. Thermalstability
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5

Yu-Wen, Cheng, та 鄭喻文. "Comparison of recombinant human argininosuccinate lyase and recombinant goose δ-crystallin interaction with goose α-crystallin". Thesis, 2008. http://ndltd.ncl.edu.tw/handle/23577020140948421566.

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碩士<br>國防醫學院<br>生物化學研究所<br>96<br>Taxon-specific -crystallin, the major soluble protein component of the avian and reptilian eye lens, is considered to play a structural role in maintaining a high refractory index while ensuring transparency. However, the most astounding relationship is an evolutionary strategy of gene sharing that the taxon specific crystallins seems to be present in which the same gene product is utilized in dual function as a lens crystallin and as an enzyme in non-lens tissues. These sequence similarities such as the -crystallins are closely related to argininosuccinate ly
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6

Li, Rongyu [Verfasser]. "Protease-activated receptor 2 and α-crystallin [alpha-crystallin] : interactions and functional implications / von Rongyu Li". 2010. http://d-nb.info/1010327070/34.

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7

Jiahn-Shing, Lee, та 李建興. "α-Crystallin Possessing Molecular Chaperone Activity: Structural and Functional Study". Thesis, 1998. http://ndltd.ncl.edu.tw/handle/22537764102452161462.

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博士<br>長庚大學<br>臨床醫學研究所<br>86<br>ABSTRACT: Recently, α-crystallin is regarded as a member of small heat shock proteins. Joseph Horwitz also demonstrated in 1992 that it can act as a molecular chaperone to prevent thermal aggregation of other crystallins and enzymes. The main purpose of this thesis is to explore the relationship between the conformational states of α-crystallin and its chaperone activity. We have first determined the cDNA sequence of αB-crystallin from porcine lenses by cDNA cloning technique. It contains one complete full-length reading frame of 525 b
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8

Chis, Roxana. "Elucidation of the Protective Mechanism of α Crystallin B in Cardiomyocytes". Thesis, 2012. http://hdl.handle.net/1807/32233.

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α-Crystallin B (cryAB) is the most abundant small heat shock protein in cardiomyocytes (CMs), where it has been shown to have potent anti-apoptotic properties. The mechanism by which cryAB prevents apoptosis has not been fully characterized. Therefore, I was interested in elucidating its protective mechanism in CMs. I identified its sub-cellular localization and its binding interactors following H2O2 exposure. I found that cryAB is found in the cytosol under control conditions and that following H2O2 exposure it becomes phosphorylated and translocates to the mitochondria. CryAB silencing resul
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9

Lin, Tsuen-Pei, та 林春霈. "Characterization of Thermal-Induced High Molecular Weight Aggregate of Rat Lens α-Crystallin". Thesis, 2003. http://ndltd.ncl.edu.tw/handle/s33s4j.

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碩士<br>國立成功大學<br>化學系碩博士班<br>91<br>α-Crystallin and high molecular weight aggregate (HMWA) were isolated from four weeks old Rat lenses. α-Crystallin was further heated at various temperatures (50-60℃) to induce thermal aggregation of HMWA, which was used to make a compare with in vivo HMWA. Spectroscopic measurement were performed to study the structure and functionality of both HMWA. Conformation differences of native HMWA were suggested based on the data of increased trytophan (Trp), non- tryptophan (non-Trp), 1-anilino- naphthalene-8-sulfonic acid (ANS), and 2-(4’-maleimidylanilino) naphthal
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10

an, chuang sheng, та 莊勝安. "The Study of Rat Lens α-crystallin Under the Effects of Mg2+ and pH". Thesis, 1999. http://ndltd.ncl.edu.tw/handle/76335158433239884381.

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碩士<br>國立成功大學<br>化學系<br>87<br>Fluoroscence spectroscopy, circular dichroism spectroscopy (CD), and fast protein liquid chromatography (FPLC) have been used to study the aggregation of rat lens α-crystallin under the effects of Mg2+, trifluoroethanol and pH. The chaperone activity of α-crystallin toward ditiothreitol-induced insulin aggregation was measured under various concentration of Mg2+ and the activity was correlated with the structural change of α-crystallin. It was observed that ANS and tryptophan fluorescence emissions increased as the concentration of Mg2+ increased, indicating α-cry
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11

Brockwell, Chris Hamilton. "The effect of pH on the structure and function of α-crystallin and cyclodextrins as artificial molecular chaperones". 2009. http://hdl.handle.net/2440/54628.

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As the major protein of the lens, α-crystallin is a molecular chaperone that stabilises lens proteins to prevent their precipitation into solution. In this role it is vital in maintaining lens transparency. The chaperone ability of α-crystallin and its individual subunits, αΑ- and αB-crystallin, has been shown to be sensitive to a variety of environmental and intrinsic factors, including temperature, denaturation and post-translational modification. The effect of pH on α-crystallin chaperone ability, however, has not been thoroughly investigated. There is limited evidence to suggest that the c
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12

Wu, Ming-tsung, та 吳明聰. "The Study of Rat Lens α-Crystallin on the Structure-Chaperone Activity Under Oxidative Stress". Thesis, 1999. http://ndltd.ncl.edu.tw/handle/09825900482198853280.

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碩士<br>國立成功大學<br>化學系<br>87<br>In this study, circular (CD) and ANS fluorescence emission have been used to study the structural change of both the oxidized rat lens a-crystallin and the dialyzed oxidatively insulted a-crystallin by Ascorbate-FeCl3-EDTA-H2O2 oxidation system. The study of the relationship between secondary structure of a-crystallin and its chaperone activity under various times of oxidation then followed by dialysis was also studied. It was found that ANS fluorescence emission intensity increased as oxidation time increased. And the intensity was higher than normal a-crystallin
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13

Tsai, Kuo-Wei, та 蔡國威. "Expression of Bullfrog α-Crystallin in E. coli Enhances Viability of Recombinant Cells under UV Stress". Thesis, 2001. http://ndltd.ncl.edu.tw/handle/74905780905506704407.

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碩士<br>國立臺灣大學<br>生化科學研究所<br>89<br>Alpha-crystallins, the major components of lens proteins, contribute to lens proteins stability and confer UV resistance potency to lens epithelial cells. We introduced bullfrog αA and αB-crystallin genes to E.coli and induced their expression, these recombinant cells showed significant UV resistance up to more then 10 times survival ratios relative to control cells, which were consistent with those of previous reports in lens epithelial cells. UV resistance of E.coli transformed by truncated form of alpha-crystallins gene constructs showed that the N-terminal
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14

Wei, Yi-Yu, та 韋宜妤. "Study on the denaturation mechanism of human Argininosuccinate Lyase and the effect by adding α-crystallin during freezing". Thesis, 2010. http://ndltd.ncl.edu.tw/handle/67372894457074378187.

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碩士<br>國防醫學院<br>生物化學研究所<br>98<br>英文摘要 Freezing is a very important operation in the biotechnological and biopharmaceutical industries, but it may result in freezing damage to the bioproducts. In this work, an attempt was made to examine and explain in qualitative and quantitative terms, the effect of freezing and thawing rate on protein damage and to investigate the minimization of protein damage and the additives of α-crystallin during freezing by optimizing the freezing protocols and solution conditions. The result showed that human argininosuccinate lyase (HASL) was highly inactivated during
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15

Wan, Chieh-Hao, та 萬傑豪. "Study for the Series of α-Methylstilbene Liquid Crystals and theirs Carbonate Liquid Crystalline Polymers". Thesis, 2001. http://ndltd.ncl.edu.tw/handle/09841308103727998199.

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博士<br>國立成功大學<br>化學工程學系<br>89<br>The chemical structures of all the synthesized compounds were characterized by 1H-NMR, 13C-NMR and elemental analysis. FTIR, DSC, POM, TGA and Wide Angle X-ray were used to study the mesomorphism and liquid crystal properties of the synthesized compounds. This research used α-methylstilbene as mesogen. A homologues series of the compounds containing various lengths of alkyl chain terminated with hydroxyl group as spacer, 4,4’-bis(hydroxyalkyloxy)-α-methylstilbenes, denoted HAMS-n, has been synthesized. Here n is the carbon atom number of the periphera
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16

Vragović, Igor [Verfasser]. "Frenkel exciton model of excitation and recombination processes in crystalline α-PTCDA [Alpha-PTCDA] / vorgelegt von Igor Vragović". 2003. http://d-nb.info/969827857/34.

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17

Hui-hung, Liu, та 劉惠宏. "Crystallite Size Effects of θ-Al2O3 on the Thermal Behavior of θ to α-Al2O3 Phase Transformation". Thesis, 1998. http://ndltd.ncl.edu.tw/handle/40347367239007911001.

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18

Yan-WeiLiou та 劉晏維. "Effects of Anti-Reflection Coating on α-Si:H/nc-Si Composite Thin Film and Paste Screen Printing Poly Crystalline Silicon Solar Cell Efficiency". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/11264205766977851680.

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19

Niyamakom, Phenwisa [Verfasser]. "Influence of deposition parameters on morphology, growth and structure of crystalline and amorphous organic thin films : (the case of perylene and α-NPD [alpha-NPD]) / vorgelegt von Phenwisa Niyamakom". 2008. http://d-nb.info/992895820/34.

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