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Journal articles on the topic 'Α-solanidine'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Ostrikova, T. O., N. G. Bogomolov, P. Yu Mylnikov, A. V. Shchulkin та I. V. Chernykh. "Development and validation of methods for quantitative determination of α-solanine, α-chaconine, solanidine in extracts from potato tuber peels BY High-performance liquid chromatography–tandem mass spectrometry". Pharmacy & Pharmacology 12, № 2 (2024): 117–30. https://doi.org/10.19163/2307-9266-2024-12-2-117-130.

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Promising metabolites of potato tuberosum (Solanum tuberosum L., f. Solanaceae) are α-solanine, α-chaconine and their aglycone solanidine.The aim of the work was to develop and validate methods for a quantitative analysis of α-solanine, α-chaconine and solanidine in dry extracts from the potato tuber peels by a high-performance liquid chromatography with a tandem mass-selective detection (HPLC/MS/MS).Materials and methods. The analysis was performed in a gradient mode on an Ultimate 3000 chromatograph (ThermoFisher, USA) with a TSQ Fortis tandem mass-selective detector and a 4.6 mm×100 mm, 5 μ

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2

Punegov, Vasily Vitalievich, Ivan Vladimirovich Gruzdev, Sergey Aleksadrovich Patov, Olga Valerievna Skrotskaya, and Konstantin Vithalievich Chucha. "QUANTITATIVE DETERMINATION OF GLYCOALKALOIDS IN POTATO TUBERS OF VARIETIES "KREPYSH" AND "ROZARA" WHEN CULTIVATED IN THE CONDITIONS OF THE MIDDLE TAIGA SUBZONE OF THE REPUBLIC OF KOMI." chemistry of plant raw material, no. 2 (June 17, 2024): 302–9. https://doi.org/10.14258/jcprm.20240213158.

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The aim of the work was the quantitative determination of glycoalkaloids (GLA) in two varieties of potatoes - Krepysh and Rosara after long-term storage of the crop. It was planned to solve the following tasks: to extract the amount of GLA from samples of potato tubers of the indicated varieties, to determine the presence of GLA in the extract with the identification of solanidine aglycone, to perform a quantitative analysis of the mass fraction of α-chaconine and α-solanine in raw plant material by HPLC analysis. Hydrolytic extraction was used to isolate the GLA fraction of potato varieties K

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3

Ostrikova, Tatyana Olegovna, Nikita Gennadievich Bogomolov, Aleksey Vladimirovich Shchulkin, Pavel Yuryevich Mylnikov, and Ivan Vladimirovich Chernykh. "DEVELOPMENT OF A TECHNIQUE FOR LIQUID EXTRACTION OF THE AMOUNT OF GLYCOALKALOIDS FROM THE PEEL OF TUBEROUS POTATO TUBERS (SOLANUM TUBEROSUM, F. SOLANACEAE)." chemistry of plant raw material, no. 1 (March 9, 2025): 254–65. https://doi.org/10.14258/jcprm.20250115267.

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Glycoalkaloids (HA) of plants of the Solanaceae family (in particular tuberous potatoes) such as α-solanine and α-chaconin have a wide range of pharmacological effects: antimicrobial, antifungal, antitumor, etc., as demonstrated by the use of individual substances and on various extracts. The use of substances of these substances in practice as medicines has little prospect due to the high cost and foreign production. In this regard, the aim of the work was to develop an economical method for extracting the amount of HA from the standardized peel of tuberous potato tubers to obtain a dry extra

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4

Dahlin, Paul, Marion C. Müller, Sophia Ekengren, Lauren S. McKee, and Vincent Bulone. "The Impact of Steroidal Glycoalkaloids on the Physiology of Phytophthora infestans, the Causative Agent of Potato Late Blight." Molecular Plant-Microbe Interactions® 30, no. 7 (2017): 531–42. http://dx.doi.org/10.1094/mpmi-09-16-0186-r.

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Steroidal glycoalkaloids (SGAs) are plant secondary metabolites known to be toxic to animals and humans and that have putative roles in defense against pests. The proposed mechanisms of SGA toxicity are sterol-mediated disruption of membranes and inhibition of cholinesterase activity in neurons. It has been suggested that phytopathogenic microorganisms can overcome SGA toxicity by enzymatic deglycosylation of SGAs. Here, we have explored SGA-mediated toxicity toward the invasive oomycete Phytophthora infestans, the causative agent of the late blight disease in potato and tomato, as well as the

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5

Nielsen, Søren D., Jesper M. Schmidt, Gitte H. Kristiansen, Trine K. Dalsgaard та Lotte B. Larsen. "Liquid Chromatography Mass Spectrometry Quantification of α-solanine, α-chaconine, and Solanidine in Potato Protein Isolates". Foods 9, № 4 (2020): 416. http://dx.doi.org/10.3390/foods9040416.

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For potato proteins to be used as a food ingredient, the level of natural potato defense substances, the glycoalkaloids (GAs), should be limited. In this work, a method is developed for quantification of the two major potato GAs, α-solanine and α-chaconine, as well as for their aglycon form, solanidine, using liquid chromatography–mass spectrometry single quadrupole in single ion monitoring mode. Standard solutions of GA and a food-grade potato protein powder was used to validate the method. A linear correlation between GA concentration and the ion intensity of >0.995 was obtained for all s

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6

Okada, Kohki, та Kano Matsuo. "Development of New Antibodies and an ELISA System to Detect the Potato Alkaloids α-Solanine and α-Chaconine". Foods 12, № 8 (2023): 1621. http://dx.doi.org/10.3390/foods12081621.

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Food poisoning can be caused by the potato alkaloids α-solanine (SO) and α-chaconine (CHA). Therefore, this study aimed to establish new enzyme-linked immunosorbent assays (ELISAs) for detecting these two toxins in biological samples and potato extracts. Two antibodies that bind to solanidine, a chemical compound found in both SO and CHA, were newly developed, and two types of ELISAs (Sold1 ELISA and Sold2 ELISA) were constructed. We measured SO and CHA diluted in phosphate-buffered saline (PBS), serum, and urine. The detection performance of the two ELISAs for SO and CHA in PBS was higher tha

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7

Friedman, Mendel, та P. R. Henika. "Absence of genotoxicity of potato alkaloids α-chaconine, α-solanine and solanidine in the ames salmonella and adult and foetal erythrocyte micronucleus assays". Food and Chemical Toxicology 30, № 8 (1992): 689–94. http://dx.doi.org/10.1016/0278-6915(92)90164-g.

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8

Kalydi, Eszter, Nikoletta Murvai, Emmanuel Saridakis та ін. "Molecular encapsulation of the aminosteroid phytotoxins solanidine and α-solanine by sugammadex: new insights into atomic-level interactions". Carbohydrate Polymers 366 (жовтень 2025): 123824. https://doi.org/10.1016/j.carbpol.2025.123824.

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9

Sodipo, O.A., F. I. Abdulrahman, U.K. Sandabe та B. Wampana. "Comparative Assessment of the Total Lipid Profile, Faecal Cholesterol, Very Low Density Lipoprotein Cholesterol (VLDL-C) and Altherogenic Index (A.I.) of the Aqueous Fruit Extract of Solanum macrocarpum, α-solanidine and Antihyperlipidaemic Drugs on Triton-Induced Hyperlipdaemic Rats". Greener Journal of Medical Sciences 3, № 1 (2013): 8–17. https://doi.org/10.15580/gjms.2013.1.120212312.

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Studies were undertaken on the effect of 50mg/kg each of the aqueous fruit extract of Solanum macrocarpum, α-solanidine, (a steroidal glycoalkaloid found in the Solanaceae), three antihyperlipidaemic drugs namely nicotinic acid, simvastatin and cholestyramine) on forty two (42) rats made hyperlipidaemic by treating them with 400 mg/kg triton-X for 7 days. The rats were divided into 7 groups of 6 rats each. At 24hrs, 48hrs and 72hrs respectively, the rats in each group were humanely sacrificed and blood samples collected for analysis of total lipid profile [total cholesterol, triglyceride

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10

ZHANG, Xiuyao, Xinxin CAI та Xiaoyi ZHANG. "Determination ofα-solanine,α-chaconine and solanidine in plasma and urine by ultra-performance liquid chromatography-triple quadrupole mass spectrometry". Chinese Journal of Chromatography 32, № 6 (2014): 586. http://dx.doi.org/10.3724/sp.j.1123.2014.03001.

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11

Ahmad, Rumana. "Steroidal glycoalkaloids fromSolanum nigrumtarget cytoskeletal proteins: anin silicoanalysis." PeerJ 7 (January 3, 2019): e6012. http://dx.doi.org/10.7717/peerj.6012.

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BackgroundSolanum nigrum(black nightshade;S. nigrum), a member of family Solanaceae, has been endowed with a heterogeneous array of secondary metabolites of which the steroidal glycoalkaloids (SGAs) and steroidal saponins (SS) have vast potential to serve as anticancer agents. Since there has been much controversy regarding safety of use of glycoalkaloids as anticancer agents, this area has remained more or less unexplored. Cytoskeletal proteins like actin play an important role in maintaining cell shape, synchronizing cell division, cell motility, etc. and along with their accessory proteins

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12

Sodipo, O. A., F. I. Abdulrahman, U. K. Sandabe та B. Wampana. "Comparative Assessment of the Total Lipid Profile, Faecal Cholesterol, Very Low Density Lipoprotein Cholesterol (VLDL-C) and Altherogenic Index (A.I.) of the Aqueous Fruit Extract of Solanum macrocarpum, α-solanidine and Antihyperlipidaemic Drugs on Triton-Induced Hyperlipdaemic Rats". Greener Journal of Medical Sciences 3, № 1 (2013): 008–17. http://dx.doi.org/10.15580/gjms.2013.1.120212312.

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13

Jankauskienė, Agnė, Dominykas Aleknavičius, Šarūnas Antanaitis, et al. "The Impact of Farm and Industrial Feed Waste on the Safety Parameters of Tenebrio molitor Larvae." Processes 12, no. 1 (2023): 37. http://dx.doi.org/10.3390/pr12010037.

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The rising global demand for animal-based food has an increasingly detrimental ecological impact, exacerbated by significant food waste (approximately one-third of all food). This research aimed to analyze the possibility of changing the usually balanced feed with sustainable alternatives that remain as a by-product of the production of farms, grain processing, and breweries, thus promoting the sustainability of agriculture. The mealworm larvae were reared on different substrates: (1) agar-agar gels, wheat bran, and brewer’s yeast, (2) carrots, wheat bran, and brewer’s yeast, (3) sprouted pota

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14

Müller, Julian Peter, Jens Sarömba, Patrick Ziegler, et al. "Nutrimetric validation of solanidine as dietary‐derived CYP2D6 activity marker in vivo." Clinical Pharmacology & Therapeutics, November 16, 2023. http://dx.doi.org/10.1002/cpt.3106.

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CYP2D6 is involved in the metabolism of many drugs. Its activity is affected by pharmacogenetic variability leading to highly polymorphic phenotypes between individuals, affecting safety and efficacy of drugs. Recently, solanidine, a steroidal alkaloid from potatoes, and its metabolites, has been identified as a dietary‐derived activity marker for CYP2D6. The intraday variability in plasma within individuals has not been studied yet in healthy subjects.As part of a CYP phenotyping cocktail study with 20 healthy participants, plasma concentrations of solanidine, 4‐OH‐solanidine and 3,4‐secosola

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15

Keuter, Lucas, Alessa Wolbeck, Matthias Kasimir, Lina Schürmann, Matthias Behrens, and Hans‐Ulrich Humpf. "Structural Impact of Steroidal Glycoalkaloids: Barrier Integrity, Permeability, Metabolism, and Uptake in Intestinal Cells." Molecular Nutrition & Food Research, February 22, 2024. http://dx.doi.org/10.1002/mnfr.202300639.

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ScopePotato tubers represent an essential food component all over the world and an important supplier of carbohydrates, fiber, and valuable proteins. However, besides their health promoting effects, potatoes contain α‐solanine and α‐chaconine, which are toxic steroidal glycoalkaloids (SGAs). Other solanaceous plants like eggplants and tomatoes produce SGAs as well, different in their chemical structure. This study aims to investigate toxic effects (cholinesterase inhibition, membrane, and barrier disruption), permeability, metabolism, and structure–activity relationships of SGAs.Methods and re

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16

"Solanidine Acetate –The Modified Glycoalkaloid Imparting Toxicity in Green Coloured and Sprouted Potatoes." Journal of Chemistry: Education Research and Practice 2, no. 1 (2018). http://dx.doi.org/10.33140/jcerp/02/01/06.

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Glycoalkaloids are one of the major secondary metabolites present in potatoes and also in the entire solanaceae family. Being toxic, the main function of this compound in plants is in the mechanism of disease resistance and they also act as feeding deterrents. The glycol alkaloid content was reported to be very high in the sprouted and green coloured potatoes. The glycol alkaloids extracted from the peel of potatoes during various post harvesting stages was subjected to TLC and FT/IR analysis.LC-MS showed the presence of the glycoalkaloid, α-chaconine in the purified samples of normal, sproute

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17

Wang, Wenqian, Guangzu Du, Guangyuan Yang, Ke Zhang, Bin Chen та Guanli Xiao. "A multifunctional enzyme portfolio for α-chaconine and α-solanine degradation in the Phthorimaea operculella gut bacterium Glutamicibacter halophytocola S2 encoded in a trisaccharide utilization locus". Frontiers in Microbiology 13 (12 жовтня 2022). http://dx.doi.org/10.3389/fmicb.2022.1023698.

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Steroidal glycoalkaloids (SGAs) are secondary metabolites commonly found in members of the family Solanaceae, including potatoes, and are toxic to pests and humans. The predominant SGAs in potato are α-chaconine and α-solanine. We previously reported that Glutamicibacter halophytocola S2, a gut bacterium of the pest Phthorimaea operculella (potato tuber moth), can degrade α-chaconine and α-solanine in potatoes, which can improve the fitness of P. operculella to feed on potatoes with a high content of toxic SGAs. Glutamicibacter halophytocola S2 harbored a gene cluster containing three deglycos

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18

Okada, K., та K. Matsuo. "B-052 Establishment of New Antibodies and ELISA System to Detect the Potato Alkaloids α-Solanine and α-Chaconine". Clinical Chemistry 69, Supplement_1 (2023). http://dx.doi.org/10.1093/clinchem/hvad097.394.

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Abstract Background Food poisoning by potato alkaloids, α-solanine (SO) and α-chaconine (CHA), currently occurs worldwide, however laboratory methods have not yet been established to detect these toxins in biological samples. In this study, we established new antibodies to detect SO and CHA and evaluated the practicality of enzyme-linked immunosorbent assays (ELISAs) using these antibodies in laboratory medicine. Methods Solanidine, a chemical compound found in both SO and CHA, was conjugated with bovine albumin, and this complex was repeatedly injected into two rabbits for two months. Two typ

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19

Okada, K. "B-292 Detection of natural toxins derived from potatoes by biotin-streptavidin direct ELISA." Clinical Chemistry 70, Supplement_1 (2024). http://dx.doi.org/10.1093/clinchem/hvae106.649.

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Abstract Background α-solanine (SO) and α-chaconine (CHA) are natural toxins of potato and often cause food poisoning worldwide. We have previously developed a polyclonal antibody (anti-Sold antibody) that bind to SO and CHA and used it in an enzyme-linked immunosorbent assay (ELISA). Our previously constructed ELISA (conventional ELISA) has a weak point of low sensitivity in detecting SO and CHA, we have tried to improve it in this study. Methods Solanidine, a chemical compound found in both SO and CHA, was conjugated with bovine albumin, and this complex was repeatedly injected into two rabb

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20

Bhatt, Rohi, та Budhi Sagar Tiwari. "CRISPRi/dCas9-KRAB mediated suppression of Solanidine galactosyltransferase (sgt1) in Solanum tuberosum leads to the reduction in α-solanine level in potato tubers without any compensatory effect in α-chaconine." Biocatalysis and Agricultural Biotechnology, квітень 2024, 103133. http://dx.doi.org/10.1016/j.bcab.2024.103133.

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