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Dissertations / Theses on the topic 'Β-amino alcohols'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Xie, Sheng-Xue. "Enzymatic production of optically active acetylenic alcohols and α, β-diastereomeric amino acids". Kyoto University, 1999. http://hdl.handle.net/2433/181386.

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Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(農学)<br>甲第8010号<br>農博第1079号<br>新制||農||788(附属図書館)<br>学位論文||H11||N3314(農学部図書室)<br>UT51-99-S300<br>京都大学大学院農学研究科農芸化学専攻<br>(主査)教授清水昌, 教授上野民夫, 教授加藤暢夫<br>学位規則第4条第1項該当

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2

Calow, Adam Daniel James. "Catalytic asymmetric borylation of α,β-unsaturated imines : a route to γ-amino alcohols". Thesis, Durham University, 2015. http://etheses.dur.ac.uk/10950/.

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This thesis describes the asymmetric synthesis of γ-amino alcohols through the asymmetric copper-catalysed β-boration of α,β-unsaturated imines. An introduction is given into the area of β-boration/borylation (or boron conjugate addition, BCA) of electron-deficient alkenes, which forms the basis of the literature review within this thesis. The β-boration of α,β-unsaturated imines (formed in situ to circumvent problems with isolation) has been studied and the intermediate β-boryl imines have been transformed to γ-amino alcohols in one-pot (‘one-pot methodology’). An interesting side reaction wa

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3

Stridfeldt, Elin. "Amino Alcohols from Asymmetric Transfer Hydrogenation of α-Amido-β-Keto Esters Possessing Olefins: Formal Total Synthesis of Sphingosine". Thesis, KTH, Skolan för kemivetenskap (CHE), 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-156316.

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In this thesis a methodology to synthesize anti-β-hydroxy-α-amino esters possessing olefins has been investigated. The developed procedures originate from two already established procedures in which α-amido-β-keto esters, which do not contain olefins, has been stereoselectively reduced to the corresponding anti-β-hydroxy-α-amino alcohols via asymmetric transfer hydrogenation coupled with dynamic kinetic resolution. Both established methods, one solvent free and one emulsion procedure, have been investigated on the expanded substrate scoop. Four different α-amido-β-keto ester containing olefins

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4

Peterson, Matt Anders. "Stereoselective synthesis of β-amino alcohols and glycosphingolipids: N-diphenylmethylene protection for tandem C-C/C-O bond formation". Diss., The University of Arizona, 1992. http://hdl.handle.net/10150/186053.

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A new method for threo-selective synthesis of β-amino alcohols is described. This method employs N-diphenylmethylene-protected α-amino esters as starting materials. The α-amino ester is reduced to the oxidation state of an aldehyde with DIBAL or DIBAL:TRIBAL (1:1) followed by sequential addition of various Grignards and alkenyllithiums. The method is highly threo-selective (stereoselectivities ranged from 8:1 to > 20:1) and provides norpseudoephedrine and threo-sphingosine analogs in enantiomerically enriched form (> 97% ee). The mechanism of C-C bond formation was examined. A stable aluminoxy

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5

Neouchy, Zeïna. "Couplage croisé d’éthers d’énol méthyliques par activation de liaisons C(sp2)-OCH3 catalysée par le nickel et Synthèse d’amines α-trifluorométhylées acycliques optiquement activespar réarrangement de β-aminoalcools α-trifluorométhylés". Thesis, Paris Sciences et Lettres (ComUE), 2018. http://www.theses.fr/2018PSLET016.

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En chimie organique, le développement de méthodes de synthèse robustes et respectueuses de l’environnement a toujours été un défi. De plus, en chimie médicinale, la mise au point de méthodes de synthèse de synthons fluorés de haute valeur ajoutée sont importantes pour avoir accès à des composés bioactifs. Dans ce manuscrit, nous présentons des méthodes efficaces et faciles à mettre en œuvre pour la formation de liaisons carbone-carbone catalysée par le nickel et la formation de liaisons carbone hétéroatome par un réarrangement de β aminoalcools α-trifluorométhylés.Nous avons montré que le coup

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6

エカ, プトラアンギ, and Anggi Eka Putra. "Studies on ruthenium-catalyzed "Borrowing Hydrogen"-based organic reactions." Thesis, https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB12905970/?lang=0, 2014. https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB12905970/?lang=0.

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特異なルテニウムが触媒する"Borrowing hydrogen"のコンセプトに基づく有機反応を開発した。まず、Ru/JOSIPHOS触媒を用いて、1,2-ジオールとアミンの反応から光学活性β-アミノアルコールを最高99%収率ならびに77% eeで得ることに成功した。本反応は新規であり、その反応機構についても明らかにした。さらに、RuCl2(PPh3)3/DPEphos/K3PO4を組み合わせた触媒を用いることで、アルコールをアルキル化剤に用いるインドールの3位選択的アルキル化反応を達成した。高効率かつ広いタイプの基質に適用できる。<br>Several novel ruthenium-catalyzed "borrowing hydrogen"-based organic reaction has been developed. For very first time optically active β-amino alcohols can be sinthesized directy by reaction of 1,2-diol and coressponding amine under Ru/JOSIPHOS catalysis in up to 99% yield and 77% ee. Since this reaction is very new, intensiv

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7

Danielsson, Jakob. "Stereoselective Nucleophilic Additions to Aldehydes and Synthesis of α-Amino-β- Hydroxy-Esters". Licentiate thesis, KTH, Organisk kemi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-95467.

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This thesis deals with the development of new reaction methodology as well as stereochemical investigations. The first part concerns the investigation of 1,2- and merged 1,2- and 1,3- asymmetric induction in Mukaiyama aldol additions to α-heteroatom and α,β- heteroatom substituted aldehydes respectively. In particular, the unexpected 1,2-syn selectivity obtained in the addition of sterically hindered nucleophiles to α-chloroaldehydes is examined, and an explanation for the observed stereochemical trends is proposed. The second part describes the development of a novel entry to α-amino-β- hydro

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8

Huang, Wei Ming, та 黃偉銘. "Asymmetric Addition Reactions Catalyzed by Camphor-Derived Chiral β-Amino Alcohols and β-Amino Thiols". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/75m7z7.

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博士<br>國立清華大學<br>化學系<br>104<br>因申請專利緣故，資料延後公開 This thesis reports the application of camphor-derived chiral β-amino alcohols and β-amino thiols in asymmetric addition reactions. In the first part, a series of chiral amino alcohols 12a–l has been synthesized and used in the enantioselective addition of dialkylzinc to aromatic aldimines. Application of the optimal chiral ligand 12a (10 mol%) with methanol (1.8 equiv.) as the additive to activate the reaction of aromatic aldimines with diethylzinc and dimethylzinc resulted in high yields (60–92%) and enantioselectivities (84–96% ee). In th

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9

Rantanen, Toni [Verfasser]. "Novel enantiopure β-amino [beta-amino] alcohols and β-amino [beta-amino] thiols in asymmetric catalysis / vorgelegt von Toni Rantanen". 2007. http://d-nb.info/984682716/34.

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10

詹淑怡. "Asymmetric Reformatsky Reaction Catalyzed by Camphor-derives β-Amino Alcohols as Chiral Ligands". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/72168733135956251457.

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11

Chang, Shiuan-kai, та 張軒愷. "Steric and Electronic Effects around the α-Carbon on β-Amino Alcohols in the Benzyne-Induced Olefination". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/03847100051464230641.

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碩士<br>國立中央大學<br>化學研究所<br>100<br>A new, stereospecific olefin synthesis from β-Amino alcohols: β-Amino alcohols was treated with CS2 in acetonitrile to produce 1,3-thiazolidine-2-thiones. 1,3-Thiazolidine-2-thiones was then added to a solution of 2-(trimethylsilylphenyl) trifluoromethanesulfonate and CsF in acetonitrile at room temperature. This would make [3 + 2] cycloaddition to give olefin products, along with side product N-benzyl-2-imino-1,3-benzodithioles. There are various factors like stereospecificity, hinderance of substituents, and electronic repulsion effect the olefination reaction

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12

Chen, Li-jyun, та 陳麗君. "Electronic and Steric Effects around the β-Carbon of theβ-Amino Alcohols in Their Conversion to Alkenes". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/99111556504375806792.

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碩士<br>國立中央大學<br>化學研究所<br>100<br>The carbon–carbon bond plays an important role in organic chemstry, and its stereospecificity has been one of the issues that chemists have to challenge in the process of organic synthesis. Most important of all, the stereospecificity of the carbon-carbon bond in the biochemistry is the key to affect the activity of the biomolecules. Hence, there is a must to develop a new method to synthesize the carbon-carbon bond. Our laboratory has been published a new method to synthesize the the carbon-carbon bond in 2011. In our new method, we use β-amino alcohols as

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13

Feng, Chen-Wei, та 馮承偉. "A Study Towards the Enantioselective Addition of Diethylzinc to Aldehydes Catalyzed by (1S)-(-)-α-Pinene based β-Amino Alcohols". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/cfu45u.

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碩士<br>國立中興大學<br>化學系所<br>99<br>Alcohols are an important intermediate in many functional group transformations. Optically active secondary alcohols are often part of the of structure a wide variety of drugs and natural products. Therefore, preparation of optically active alcohols is an important synthetic topic in organic synthesis. Here, we report the development of catalysts for asymmetric addition of diethylzinc to aldehydes affording the corresponding secondary alcohols in high yields and high enantioselectivity. The synthetic precursor, hydroxy sulfonamide 20, was synthesized from (1S)-(-

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14

Açıkalın, Serdar [Verfasser]. "Enantioselective synthesis of cyclic β-amino [beta amino] alcohols via tandem hydroalumination cyclization reduction of ethoxycarbonyl vinyl sulfoximines and application to the synthesis of potential aggrecanase inhibitors / vorgelegt von Serdar Açıkalın". 2009. http://d-nb.info/999784145/34.

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15

Tseng, Chih-Hao, та 曾志豪. "The Study on Asymmetric Nucleophilic Addition Reaction Catalyzed by Camphor Derived Chiral β-Amino Alcohol and β-Amino Thiol". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/45559250610104053101.

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博士<br>國立清華大學<br>化學系<br>99<br>This thesis, divided into three parts, is concerned with the application of camphor-derived chiral β-amino alcohol or β-amino thiol in catalytic asymmetric conjugate addition of carbon nucleophiles to α,β-unsaturated systems and asymmetric addition reactions of organozinc to carbonyl compounds. The first part has discuss the complex of (+)-MINBOL 28 and Ni(acac)2 (12.5 mol% and 0.5 mol% respectively) catalyzes enantioselective conjugate 1,4-addition of dialkylzinc to α,β-unsaturated enones in propionitrile, giving the corresponding chiral Michael adducts in high e

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16

Jheng, Jing-Yan, та 鄭敬嚴. "Catalytic Asymmetric Reduction of Acetophenone by Ru and Chiral Camphor-derivatived β-amino alcohol". Thesis, 2006. http://ndltd.ncl.edu.tw/handle/66714182051593135071.

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碩士<br>國立成功大學<br>化學系碩博士班<br>94<br>Camphor is widely applied to catalytic asymmetric synthesis because of it’s two nature chiral center. We design and synthesis β-amino alcohol from camphor by a very highly stereoselecviv -e route and then we modify several different substituent group on the nitrogen. We achieve the goal by reductive amination because we want to get secondary amines. Instead of imines, we get the 5 member oxazolidine rings. Then open the rings, we obtain the desired Compound. Finally we apply the β-amino alcohols to the rutheniu catalytic asymmetric synthesis.

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17

Shen, Ying-Ying, та 沈盈瑩. "The Synthesis and Application of Camphor Derived Chiral γ-Amido Thiol and β-Amino Alcohol Ligand". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/3f9sj4.

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碩士<br>國立清華大學<br>化學系<br>101<br>This thesis dealt with the development of new chiral ligands, γ-amido thiol (10) and β-amino alcohol (11), based on γ-amino thiol(-)-MITH (2) and β- amino alcohol (+)-MINBOL (3), respectively. Furthermore, this thesis also dealt with the application of β-amino alcohol (11) in catalytic asymmetric addition reactions of diethylzinc and arylzinc to aldehydes to construct chiral secondary alcohols. Asymmetric ethylation using a stock solution of diethylzinc (1.1 M in toluene) was carried out in the presence of 0.5 mol % of β-amino alcohol (11) at room temperature and

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18

Chen, An Jyun, та 陳安君. "The Study on Asymmetric Tandem Michael/Mannich Reaction of Diethylzinc to trans-chalcone by Camphor Derived Chiral β-Amino Alcohol". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/9qj747.

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碩士<br>國立清華大學<br>化學系<br>103<br>The thesis dealt with the application of camphor-derived chiral ß-amino alcohol in catalytic asymmetric tandem Michael/Mannich reaction of diethylzinc to trans-chalcone. Utilizing the complex of (+)-MINBOL 6 (12.5 mol%) and Ni(acac)2 (0.5 mol%) catalyzed the enantioselective conjugate 1,4-addition of diethylzinc to trans-chalcone 12 afforded chiral zinc enolate 13. The chiral zinc enolate 13 was further reacted with imine 14a-k, which furnished Major products ß-amino ketone 4a-k (1S,2R,3S) with high enantioselectivity and good yield.

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