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Relevant bibliographies by topics / Β-glucuronidase Inhibition

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Academic literature on the topic 'Β-glucuronidase Inhibition'

Author: Grafiati

Published: 4 June 2025

Last updated: 15 July 2025

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Journal articles on the topic "Β-glucuronidase Inhibition"

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Bai, Yue, Lu Chen, Yun-Feng Cao, et al. "Beta-Glucuronidase Inhibition by Constituents of Mulberry Bark." Planta Medica 87, no. 08 (2021): 631–41. http://dx.doi.org/10.1055/a-1402-6431.

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AbstractIntestinal bacterial β-glucuronidases, the key enzymes responsible for the hydrolysis of various glucuronides into free aglycone, have been recognized as key targets for treating various intestinal diseases. This study aimed to investigate the inhibitory effects and mechanisms of the Mulberry bark constituents on E. coli β-glucuronidase (EcGUS), the most abundant β-glucuronidases produced by intestinal bacteria. The results showed that the flavonoids isolated from Mulberry bark could strongly inhibit E. coli β-glucuronidase, with IC50 values ranging from 1.12 µM to 10.63 µM, which were

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Bae, Hyung-Sup, Young-Suk Kim, Ki-Ho Cho та ін. "Hepatoprotective Activity of Reduohanxiao-tang (Yuldahanso-tang) is Related to the Inhibition of β-Glucuronidase". American Journal of Chinese Medicine 31, № 01 (2003): 111–17. http://dx.doi.org/10.1142/s0192415x03000722.

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β-Glucuronidase-inhibitory and hepatoprotective effects of Reduohanxiao-tang (Yuldahanso-tang), which has been used for liver diseases and stroke, on carbon tetrachloride (CCl4)-induced hepatotoxicity of rats were investigated. Reduohanxiao-tang potently inhibited β-glucuronidases. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactic acid dehydrogenase (LDH) levels of the CCl4 group orally treated with Reduohanxiao-tang (100 mg/kg) were lowered to 54%, 71.5% and 66.1% of the CCl4-treated control group, respectively. Among the ingredients of the Reduohanxiao-tang, t

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Yang, Wei, Bin Wei та Ru Yan. "Amoxapine Demonstrates Incomplete Inhibition of β-Glucuronidase Activity from Human Gut Microbiota". SLAS DISCOVERY: Advancing the Science of Drug Discovery 23, № 1 (2017): 76–83. http://dx.doi.org/10.1177/2472555217725264.

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Amoxapine has been demonstrated to be a potent inhibitor of Escherichia coli β-glucuronidase. This study aims to explore the factors causing unsatisfactory efficacy of amoxapine in alleviating CPT-11–induced gastrointestinal toxicity in mice and to predict the outcomes in humans. Amoxapine (100 µM) exhibited poor and varied inhibition on β-glucuronidase activity in gut microbiota from 10 healthy individuals and their pool (pool, 11.9%; individuals, 3.6%−54.4%) with IC50 >100 µM and potent inhibition toward E. coli β-glucuronidase (IC50 = 0.34 µM). p-Nitrophenol formation from p-nitrophenyl-

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Sacco, C., та E. J. Calabrese. "Selective Inhibition of Gastrointestinal β-Glucuronidase by Poly(vinylbenzyl D-glucaro(1,4)lactonate). Part 2. Poly(vinylbenzyl D-Glucaro(1,4) lactonate) In vitro Inhibition Studies". Human & Experimental Toxicology 13, № 11 (1994): 759–63. http://dx.doi.org/10.1177/096032719401301104.

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In vitro inhibition studies with β-glucuronidase from purified E. coli and mouse intestinal contents indicated that the polymer, poly(vinylbenzyl D-glucaro(1,4)lactonate, is an effective β-glucuronidase inhibitor. Purified E. coli β-glucuronidase was inhibited by 99.6% with 1 77 mM D-glucaro(1,4)lactone using the polymer-inhibitor. Similarly, 95% inhibition of β-glucuronidase activity of mouse intestinal contents was obtained with 177 mM and 50% inhibition was obtained with 31.5 mM D-glucaro(1,4)lactone based on the modified polymer. The structural requirements of an effective β-glucuronidase

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Gourley, Glenn R., Bill L. Kreamer та Monika Cohnen. "Inhibition of β‐Glucuronidase by Casein Hydrolysate Formula". Journal of Pediatric Gastroenterology and Nutrition 25, № 3 (1997): 267–72. http://dx.doi.org/10.1002/j.1536-4801.1997.tb01747.x.

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Background:A casein hydrolysate infant formula has been shown to be associated with lower levels of neonatal jaundice than are standard infant formulas. Because β‐glucuronidase is related to neonatal jaundice, this study examined the effect of a casein hydrolysate formula on β‐glucuronidase.Methods:β‐glucuronidase activity was measured with or without added dietary components. The β‐glucuronidase sources used were meconium, breast milk, and the purified bovine liver enzyme. The dietary components assayed for their effect on β‐glucuronidase activity included casein hydrolysate formula (Nutramig

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Rauf, Abdur, Rahaf Ajaj, Zuneera Akram, et al. "Investigation of the inhibitory potential of secondary metabolites isolated from Fernandoa adenophylla against Beta-glucuronidase via molecular docking and molecular dynamics simulation studies." PLOS One 20, no. 5 (2025): e0324100. https://doi.org/10.1371/journal.pone.0324100.

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Elevated β-glucuronidase activity is associated with the production of toxic metabolites that contribute to tumor development and other diseases. Inhibiting this enzyme may offer therapeutic potential, including the prevention of colonic carcinogenesis. This study investigates the antidiabetic potential of metabolites derived from Fernandoa adenophylla, using β-glucuronidase as a model enzyme linked to hyperglycemia. Both Escherichia coli and human isoforms of β-glucuronidase were evaluated. Among the tested compounds, AA and DD exhibited the most significant inhibitory activity against the E.

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Vainstein, Alexander, Morly Fisher, and Meira Ziv. "Applicability of Reporter Genes to Carnation Transformation." HortScience 28, no. 11 (1993): 1122–24. http://dx.doi.org/10.21273/hortsci.28.11.1122.

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The applicability of β- glucuronidase and chloramphenicol acetyltransferase reporter genes to a carnation (Dianthus caryophyllus L.) transformation procedure, was analyzed. Transgenic tobacco (Nicotiana tabacum L.) plants expressing the respective reporter genes were prepared and used as the enzyme source. Carnation leaf extract strongly inhibited enzymatic activity of β- glucuronidase, but not that of chloramphenicol acetyltransferase. One or more carnation phenolic compounds, acting in a noncompetitive manner, is suggested as the cause of the observed inhibition of fluorometrically assayed β

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Anouar, El Hassane, Moustapha Eid Moustapha, Muhammad Taha та ін. "Synthesis, Molecular Docking and β-Glucuronidase Inhibitory Potential of Indole Base Oxadiazole Derivatives". Molecules 24, № 5 (2019): 963. http://dx.doi.org/10.3390/molecules24050963.

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β-glucuronidase is a lysosomal glycosidase enzyme which catalyzes the extracellular matrix of cancer and normal cells and the glycosaminoglycans of the cell membrane, which is important for cancer cell proliferation, invasion, and metastasis. Liver cancer, colon carcinoma, and neoplasm bladder are triggered by the increase of the level of β-glucuronidase activity. The most valuable structures are indole and oxadiazole which has gain immense attention because of its pharmacological behavior and display many biological properties. Twenty-two (1–22) analogs of indole based oxadiazole were synthes

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Taha, Muhammad, Nor Hadiani Ismail, Syahrul Imran та ін. "Identification of bisindolylmethane–hydrazone hybrids as novel inhibitors of β-glucuronidase, DFT, and in silico SAR intimations". RSC Advances 6, № 4 (2016): 3276–89. http://dx.doi.org/10.1039/c5ra19513f.

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Phong, Nguyen Viet, Yan Zhao, Byung Sun Min, Seo Young Yang та Jeong Ah Kim. "Inhibitory Activity of Bioactive Phloroglucinols from the Rhizomes of Dryopteris crassirhizoma on Escherichia coli β-Glucuronidase: Kinetic Analysis and Molecular Docking Studies". Metabolites 12, № 10 (2022): 938. http://dx.doi.org/10.3390/metabo12100938.

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Phloroglucinols—one of the major secondary metabolites in Dryopteris crassirhizoma—exhibit various pharmacological effects, such as antiviral, antioxidant, and antidiabetic activities. This study evaluated 30 phloroglucinols isolated from the rhizomes of D. crassirhizoma for their inhibitory activity on β-glucuronidase via in vitro assays. Among them, dimeric phloroglucinols 13–15 moderately inhibited β-glucuronidase, and trimeric phloroglucinols 26–28 showed strong inhibitory effects, with IC50 values ranging from 5.6 to 8.0 μM. Enzyme kinetic analysis confirmed all six active compounds to be

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Dissertations / Theses on the topic "Β-glucuronidase Inhibition"

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Mahran, Ehab Ghareeb Mohammed [Verfasser], та Michael [Akademischer Betreuer] Keusgen. "Phytochemical and Biological Investigation of some Endemic Plants of Egypt with Development of a New HPTLC-β- Glucuronidase Inhibition Assay / Ehab Mahran ; Betreuer: Michael Keusgen". Marburg : Philipps-Universität Marburg, 2020. http://d-nb.info/1223130118/34.

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Mahran, Ehab [Verfasser], та Michael [Akademischer Betreuer] Keusgen. "Phytochemical and Biological Investigation of some Endemic Plants of Egypt with Development of a New HPTLC-β- Glucuronidase Inhibition Assay / Ehab Mahran ; Betreuer: Michael Keusgen". Marburg : Philipps-Universität Marburg, 2020. http://d-nb.info/1223130118/34.

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Tredwell, Gregory David. "An Investigation into β-Glucuronidases". Thesis, Griffith University, 2009. http://hdl.handle.net/10072/365204.

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Abstract: Conjugated carbohydrates, such as proteoglycans, play pivotal roles in a number of diverse biological processes. Their structural complexity encodes information that regulates intercellular communication, recognition events and cellular activity. As such, the biosynthesis and catabolism of these complex molecules requires the tight regulation of a large number of enzymes. Two enzymes that are of particular interest in the metabolism of glycosaminoglycans are exo-β-glucuronidase and the endo-β-glucuronidase, heparanase. These two glycosidases play an important role in the catabolism

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Dashnyam, Punsaldulam, та 朋莎朗. "Gut Bacterial β-Glucuronidases: Structural Basis of Substrate Specificity, Inhibitor Potency and Selectivity to Provide a Solution for Xenobiotic-Induced Toxicity". Thesis, 2019. http://ndltd.ncl.edu.tw/cgi-bin/gs32/gsweb.cgi/login?o=dnclcdr&s=id=%22107NCHU5111019%22.&searchmode=basic.

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博士<br>國立中興大學<br>生物科技學研究所<br>107<br>Gut bacterial β-D-glucuronidases (GUSs) catalyze the removal of glucuronic acid from liver-produced β-D-glucuronides. These reactions can have deleterious consequences when they reverse xenobiotic metabolism. The human gut contains hundreds of GUSs of variable sequences and structures. To understand how any particular bacterial GUS(s) contributes to global GUS activity and affects human health, the substrate preference(s) of individual enzymes must be known. Herein, we report that representative GUSs vary in their ability to produce various xenobiotics from t

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Conference papers on the topic "Β-glucuronidase Inhibition"

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Simone, E. R., T. A. Davies, N. A. Zabe, S. M. Greenberg-seperaky, and N. E. Larsen. "EARLY PLATELET-THROMBIN RECEPTORS AND THEIR FUNCTIONS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643730.

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Human platelets possess less than 1000 high affinity [Kd=10-9]and 50-100,000 receptors of lower [Kd=10-7] affinity for o(α-thrombin. The selective derivatization of thrombin with the bifunctional crosslinking agent, DNCO, has enabled us to identify these receptorsvia covalent binding of either active siteinhibited tosyllyslmethylketothrombin (TLCK-T) or active Ctf-thrombin (T).Kinetic studies of the inhibition of the platelet-thrombin response by covalently and noncovalently bound TLCK-T have helped to elucidate the roles of the high and low affinity thrombin receptors. The activation paramete

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