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Journal articles on the topic 'Β-glucuronidase Inhibition'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Bai, Yue, Lu Chen, Yun-Feng Cao, et al. "Beta-Glucuronidase Inhibition by Constituents of Mulberry Bark." Planta Medica 87, no. 08 (2021): 631–41. http://dx.doi.org/10.1055/a-1402-6431.

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AbstractIntestinal bacterial β-glucuronidases, the key enzymes responsible for the hydrolysis of various glucuronides into free aglycone, have been recognized as key targets for treating various intestinal diseases. This study aimed to investigate the inhibitory effects and mechanisms of the Mulberry bark constituents on E. coli β-glucuronidase (EcGUS), the most abundant β-glucuronidases produced by intestinal bacteria. The results showed that the flavonoids isolated from Mulberry bark could strongly inhibit E. coli β-glucuronidase, with IC50 values ranging from 1.12 µM to 10.63 µM, which were

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Bae, Hyung-Sup, Young-Suk Kim, Ki-Ho Cho та ін. "Hepatoprotective Activity of Reduohanxiao-tang (Yuldahanso-tang) is Related to the Inhibition of β-Glucuronidase". American Journal of Chinese Medicine 31, № 01 (2003): 111–17. http://dx.doi.org/10.1142/s0192415x03000722.

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β-Glucuronidase-inhibitory and hepatoprotective effects of Reduohanxiao-tang (Yuldahanso-tang), which has been used for liver diseases and stroke, on carbon tetrachloride (CCl4)-induced hepatotoxicity of rats were investigated. Reduohanxiao-tang potently inhibited β-glucuronidases. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactic acid dehydrogenase (LDH) levels of the CCl4 group orally treated with Reduohanxiao-tang (100 mg/kg) were lowered to 54%, 71.5% and 66.1% of the CCl4-treated control group, respectively. Among the ingredients of the Reduohanxiao-tang, t

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Yang, Wei, Bin Wei та Ru Yan. "Amoxapine Demonstrates Incomplete Inhibition of β-Glucuronidase Activity from Human Gut Microbiota". SLAS DISCOVERY: Advancing the Science of Drug Discovery 23, № 1 (2017): 76–83. http://dx.doi.org/10.1177/2472555217725264.

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Amoxapine has been demonstrated to be a potent inhibitor of Escherichia coli β-glucuronidase. This study aims to explore the factors causing unsatisfactory efficacy of amoxapine in alleviating CPT-11–induced gastrointestinal toxicity in mice and to predict the outcomes in humans. Amoxapine (100 µM) exhibited poor and varied inhibition on β-glucuronidase activity in gut microbiota from 10 healthy individuals and their pool (pool, 11.9%; individuals, 3.6%−54.4%) with IC50 >100 µM and potent inhibition toward E. coli β-glucuronidase (IC50 = 0.34 µM). p-Nitrophenol formation from p-nitrophenyl-

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4

Sacco, C., та E. J. Calabrese. "Selective Inhibition of Gastrointestinal β-Glucuronidase by Poly(vinylbenzyl D-glucaro(1,4)lactonate). Part 2. Poly(vinylbenzyl D-Glucaro(1,4) lactonate) In vitro Inhibition Studies". Human & Experimental Toxicology 13, № 11 (1994): 759–63. http://dx.doi.org/10.1177/096032719401301104.

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In vitro inhibition studies with β-glucuronidase from purified E. coli and mouse intestinal contents indicated that the polymer, poly(vinylbenzyl D-glucaro(1,4)lactonate, is an effective β-glucuronidase inhibitor. Purified E. coli β-glucuronidase was inhibited by 99.6% with 1 77 mM D-glucaro(1,4)lactone using the polymer-inhibitor. Similarly, 95% inhibition of β-glucuronidase activity of mouse intestinal contents was obtained with 177 mM and 50% inhibition was obtained with 31.5 mM D-glucaro(1,4)lactone based on the modified polymer. The structural requirements of an effective β-glucuronidase

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5

Gourley, Glenn R., Bill L. Kreamer та Monika Cohnen. "Inhibition of β‐Glucuronidase by Casein Hydrolysate Formula". Journal of Pediatric Gastroenterology and Nutrition 25, № 3 (1997): 267–72. http://dx.doi.org/10.1002/j.1536-4801.1997.tb01747.x.

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Background:A casein hydrolysate infant formula has been shown to be associated with lower levels of neonatal jaundice than are standard infant formulas. Because β‐glucuronidase is related to neonatal jaundice, this study examined the effect of a casein hydrolysate formula on β‐glucuronidase.Methods:β‐glucuronidase activity was measured with or without added dietary components. The β‐glucuronidase sources used were meconium, breast milk, and the purified bovine liver enzyme. The dietary components assayed for their effect on β‐glucuronidase activity included casein hydrolysate formula (Nutramig

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6

Rauf, Abdur, Rahaf Ajaj, Zuneera Akram, et al. "Investigation of the inhibitory potential of secondary metabolites isolated from Fernandoa adenophylla against Beta-glucuronidase via molecular docking and molecular dynamics simulation studies." PLOS One 20, no. 5 (2025): e0324100. https://doi.org/10.1371/journal.pone.0324100.

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Elevated β-glucuronidase activity is associated with the production of toxic metabolites that contribute to tumor development and other diseases. Inhibiting this enzyme may offer therapeutic potential, including the prevention of colonic carcinogenesis. This study investigates the antidiabetic potential of metabolites derived from Fernandoa adenophylla, using β-glucuronidase as a model enzyme linked to hyperglycemia. Both Escherichia coli and human isoforms of β-glucuronidase were evaluated. Among the tested compounds, AA and DD exhibited the most significant inhibitory activity against the E.

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Vainstein, Alexander, Morly Fisher, and Meira Ziv. "Applicability of Reporter Genes to Carnation Transformation." HortScience 28, no. 11 (1993): 1122–24. http://dx.doi.org/10.21273/hortsci.28.11.1122.

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The applicability of β- glucuronidase and chloramphenicol acetyltransferase reporter genes to a carnation (Dianthus caryophyllus L.) transformation procedure, was analyzed. Transgenic tobacco (Nicotiana tabacum L.) plants expressing the respective reporter genes were prepared and used as the enzyme source. Carnation leaf extract strongly inhibited enzymatic activity of β- glucuronidase, but not that of chloramphenicol acetyltransferase. One or more carnation phenolic compounds, acting in a noncompetitive manner, is suggested as the cause of the observed inhibition of fluorometrically assayed β

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8

Anouar, El Hassane, Moustapha Eid Moustapha, Muhammad Taha та ін. "Synthesis, Molecular Docking and β-Glucuronidase Inhibitory Potential of Indole Base Oxadiazole Derivatives". Molecules 24, № 5 (2019): 963. http://dx.doi.org/10.3390/molecules24050963.

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β-glucuronidase is a lysosomal glycosidase enzyme which catalyzes the extracellular matrix of cancer and normal cells and the glycosaminoglycans of the cell membrane, which is important for cancer cell proliferation, invasion, and metastasis. Liver cancer, colon carcinoma, and neoplasm bladder are triggered by the increase of the level of β-glucuronidase activity. The most valuable structures are indole and oxadiazole which has gain immense attention because of its pharmacological behavior and display many biological properties. Twenty-two (1–22) analogs of indole based oxadiazole were synthes

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Taha, Muhammad, Nor Hadiani Ismail, Syahrul Imran та ін. "Identification of bisindolylmethane–hydrazone hybrids as novel inhibitors of β-glucuronidase, DFT, and in silico SAR intimations". RSC Advances 6, № 4 (2016): 3276–89. http://dx.doi.org/10.1039/c5ra19513f.

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10

Phong, Nguyen Viet, Yan Zhao, Byung Sun Min, Seo Young Yang та Jeong Ah Kim. "Inhibitory Activity of Bioactive Phloroglucinols from the Rhizomes of Dryopteris crassirhizoma on Escherichia coli β-Glucuronidase: Kinetic Analysis and Molecular Docking Studies". Metabolites 12, № 10 (2022): 938. http://dx.doi.org/10.3390/metabo12100938.

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Phloroglucinols—one of the major secondary metabolites in Dryopteris crassirhizoma—exhibit various pharmacological effects, such as antiviral, antioxidant, and antidiabetic activities. This study evaluated 30 phloroglucinols isolated from the rhizomes of D. crassirhizoma for their inhibitory activity on β-glucuronidase via in vitro assays. Among them, dimeric phloroglucinols 13–15 moderately inhibited β-glucuronidase, and trimeric phloroglucinols 26–28 showed strong inhibitory effects, with IC50 values ranging from 5.6 to 8.0 μM. Enzyme kinetic analysis confirmed all six active compounds to be

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11

Gourley, Glenn R., Bill L. Kreamer та Monika Cohnen. "Inhibition of β-Glucuronidase by Casein Hydrolysate Formula". Journal of Pediatric Gastroenterology &amp Nutrition 25, № 3 (1997): 267–72. http://dx.doi.org/10.1097/00005176-199709000-00005.

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12

Young, J. C., E. M. Kenyon та E. J. Calabrese. "Inhibition of β-glucuronidase in Human Urine by Ascorbic Acid". Human & Experimental Toxicology 9, № 3 (1990): 165–70. http://dx.doi.org/10.1177/096032719000900308.

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The effects of oral supplementation of ascorbic acid (1500 mg d-1) on urinary β-glucuronidase (β-G) activity was assessed in a double-blind crossover study design over a 3-week period. The subjects on ascorbic acid treatment displayed a statistically significant (P < 0.05) decrease in β-G with an approximate decrease of 25%.

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13

Balbaa, Mahmoud, Doaa Awad, Ahmad Abd Elaal, et al. "Action of Thioglycosides of 1,2,4-Triazoles and Imidazoles on the Oxidative Stress and Glycosidases in Mice with Molecular Docking." Letters in Drug Design & Discovery 16, no. 6 (2019): 696–710. http://dx.doi.org/10.2174/1573413715666181212150955.

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Background: ,2,3-Triazoles and imidazoles are important five-membered heterocyclic scaffolds due to their extensive biological activities. These products have been an area of growing interest to many researchers around the world because of their enormous pharmaceutical scope. Methods: The in vivo and in vitro enzyme inhibition of some thioglycosides encompassing 1,2,4- triazole N1, N2, and N3 and/or imidazole moieties N4, N5, and N6. The effect on the antioxidant enzymes (superoxide dismutase, glutathione S-transferase, glutathione peroxidase and catalase) was investigated as well as their eff

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14

Taha, Muhammad, Fazal Rahim, Muhammad Ali та ін. "Synthesis of Chromen-4-One-Oxadiazole Substituted Analogs as Potent β-Glucuronidase Inhibitors". Molecules 24, № 8 (2019): 1528. http://dx.doi.org/10.3390/molecules24081528.

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Chromen-4-one substituted oxadiazole analogs 1–19 have been synthesized, characterized and evaluated for β-glucuronidase inhibition. All analogs exhibited a variable degree of β-glucuronidase inhibitory activity with IC50 values ranging in between 0.8 ± 0.1–42.3 ± 0.8 μM when compared with the standard d-saccharic acid 1,4 lactone (IC50 = 48.1 ± 1.2 μM). Structure activity relationship has been established for all compounds. Molecular docking studies were performed to predict the binding interaction of the compounds with the active site of enzyme.

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15

Chang, Han-Wel, Michael E. Friedman, Deborah L. Hileman та Edward J. Parish. "Inhibition of Human Synovial β-Glucuronidase by Steroidal Compounds". Journal of Enzyme Inhibition 6, № 4 (1993): 331–35. http://dx.doi.org/10.3109/14756369309020182.

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16

Pellock, Samuel J., Benjamin C. Creekmore, William G. Walton та ін. "Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception". ACS Central Science 4, № 7 (2018): 868–79. http://dx.doi.org/10.1021/acscentsci.8b00239.

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17

Hernández-Fuentes, Alma Delia, David Chávez-Borges, Antonio de Jesús Cenobio-Galindo, et al. "Characterization of total phenol and flavonoid contents, colour, functional properties from honey samples with different floral origins." International Journal of Food Studies 10, no. 2 (2021): 346–58. http://dx.doi.org/10.7455/ijfs/10.2.2021.a6.

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Honey has long been used as a food and has been reported to have potential health benefits. In this work, total phenol content, colour and antioxidant and hepatoprotective activities of honey samples of different floral origins from the State of Hidalgo, Mexico were explored using in vitro assays. Hepatoprotective activity was measured by inhibitition of β-glucuronidase; gastroprotective activity was determined by inhibition of urease; antioxidant activity was evaluated by 2,2'-Azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) methods. All the pa

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18

Cheng, Ta-Chun, Kuo-Hsiang Chuang, Steve R. Roffler та ін. "Discovery of Specific Inhibitors for IntestinalE. coli β-Glucuronidase throughIn SilicoVirtual Screening". Scientific World Journal 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/740815.

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Glucuronidation is a major metabolism process of detoxification for carcinogens, 4-(methylnitrosamino)-1-(3-pyridy)-1-butanone (NNK) and 1,2-dimethylhydrazine (DMH), of reactive oxygen species (ROS). However, intestinalE. coli β-glucuronidase (eβG) has been considered pivotal to colorectal carcinogenesis. Specific inhibition of eβG may prevent reactivating the glucuronide-carcinogen and protect the intestine from ROS-mediated carcinogenesis. In order to develop specific eβG inhibitors, we found that 59 candidate compounds obtained from the initial virtual screening had high inhibition specific

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19

Rahman, Atta-ur, Seema Zareen, M. Iqbal Choudhary, M. Nadeem Akhtar, Atta-ur Rahman, and F. N. Ngounou. "Some Chemical Constituents Of Terminalia Glaucescens And Their Enzymes Inhibition Activity." Zeitschrift für Naturforschung B 60, no. 3 (2005): 347–50. http://dx.doi.org/10.1515/znb-2005-0320.

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A new triterpenoid, glaucinoic acid (2α, 3β, 19α, 24-tetrahydroxyolean-12-en-30-oic acid) (1) along with several known compounds, arjunic acid (2), arjungenin (3), sericoside (4), and friedelin (5) were isolated from the stem barks of Terminalia glaucescens. These compounds showed β - glucuronidase inhibitory activity. The structures were identified on the basis of spectroscopic techniques

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20

Hashimoto, Kazuhiko, Hiroshi Saito та Ryo Ohsawa. "Glycopolymeric inhibitors of β-glucuronidase. III. Configurational effects of hydroxy groups in pendant glyco-units in polymers upon inhibition of β-glucuronidase". Journal of Polymer Science Part A: Polymer Chemistry 44, № 16 (2006): 4895–903. http://dx.doi.org/10.1002/pola.21584.

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21

Bhatt, Aadra P., Samuel J. Pellock, Kristen A. Biernat та ін. "Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy". Proceedings of the National Academy of Sciences 117, № 13 (2020): 7374–81. http://dx.doi.org/10.1073/pnas.1918095117.

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Irinotecan treats a range of solid tumors, but its effectiveness is severely limited by gastrointestinal (GI) tract toxicity caused by gut bacterial β-glucuronidase (GUS) enzymes. Targeted bacterial GUS inhibitors have been shown to partially alleviate irinotecan-induced GI tract damage and resultant diarrhea in mice. Here, we unravel the mechanistic basis for GI protection by gut microbial GUS inhibitors using in vivo models. We use in vitro, in fimo, and in vivo models to determine whether GUS inhibition alters the anticancer efficacy of irinotecan. We demonstrate that a single dose of irino

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22

Rasool, Mahaboobkhan, Sonal Chandal, and Evan Prince Sabina. "Inhibition of Monosodium Urate Crystal-Induced Inflammation by Withaferin A." Journal of Pharmacy & Pharmaceutical Sciences 11, no. 4 (2009): 46. http://dx.doi.org/10.18433/j35k58.

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ABSTRACT  Purpose. Gouty arthritis is a characteristically intense acute inflammatory reaction resulting from the formation of sodium urate crystals in the joint cavity. In the present study, the effect of withaferin A, a steroidal lactone was investigated on monosodium urate crystal-induced inflammation in mice; an experimental model for gouty arthritis and compared it with that of the non-steroidal anti-inflammatory drug, indomethacin.  Methods. Paw volume and levels/activities of lysosomal enzymes, lipid peroxidation, anti-oxidant status and inflammatory mediator TNF-α were dete

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23

Jamil, Waqas, Darshana Kumari, Muhammad Taha та ін. "Synthesis, β-Glucuronidase Inhibition, and Molecular Docking Studies of 1,2,4-Triazole Hydrazones". Journal of the Iranian Chemical Society 15, № 11 (2018): 2441–54. http://dx.doi.org/10.1007/s13738-018-1433-9.

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24

Schmeda-Hirschmann, G., J. I. Loyola, S. Reyes та ін. "β-glucuronidase inhibition and diuretic activity ofFabiana imbricata R. & P. (Solanaceae)". Phytotherapy Research 8, № 8 (1994): 485–87. http://dx.doi.org/10.1002/ptr.2650080810.

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Medina-Pérez, Gabriela, Laura Peralta-Adauto, Laura Afanador-Barajas та ін. "Inhibition of Urease, Elastase, and β-Glucuronidase Enzymatic Activity by Applying Aqueous Extracts of Opuntia oligacantha C.F. Först Acid Fruits: In Vitro Essay under Simulated Digestive Conditions". Applied Sciences 11, № 16 (2021): 7705. http://dx.doi.org/10.3390/app11167705.

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Non-communicable diseases such as gastric inflammatory diseases and the hepatic pathologies are mainly related to bad lifestyle habits such as recurrent consumption of non-steroidal anti-inflammatory drugs (NSAIDs), excessive intake of alcohol, tobacco, steroids (high doses), alkaline agents, strong acid foods, and high-fat food, and Helicobacter pylori infections, among others. The fruit of Opuntia oligacantha C.F. Först var. Ulapa (xoconostle) is currently being studied due its nutritional and functional properties. The objective of the present study was to evaluate gastroprotective, anti-in

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Robert, Laurian S., Pauline A. Donaldson, Christine Ladaique, Illimar Altosaar, Paul G. Arnison та Steven F. Fabijanski. "Antisense RNA Inhibition of β-Glucuronidase Gene Expression in Transgenic Tobacco can be Transiently Overcome Using a Heat-Inducible β-Glucuronidase Gene Construct". Nature Biotechnology 8, № 5 (1990): 459–64. http://dx.doi.org/10.1038/nbt0590-459.

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27

Yousuf, Maria. "Advances in In-Silico based Predictive In-Vivo Profiling of Novel Potent β-Glucuronidase Inhibitors". Current Cancer Drug Targets 19, № 11 (2019): 906–18. http://dx.doi.org/10.2174/1568009619666190320102238.

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Background: Intestinal β-glucuronidase enzyme has a significant importance in colorectal carcinogenesis. Specific inhibition of the enzyme helps prevent immune reactivation of the glucuronide- carcinogens, thus protecting the intestine from ROS (Reactive Oxidative Species) mediatedcarcinogenesis. Objective: Advancement in In-silico based techniques has provided a broad range of studies to carry out the drug design and development process smoothly using SwissADME and BOILED-Egg tools. Methods: In our designed case study, we used SwissADME and BOILED-Egg predictive computational tools to estimat

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Remirez, Diadelis, Ricardo González, Nelson Merino, Sandra Rodriguez, and Odelsa Ancheta. "Inhibitory effects of Spirulina in zymosan-induced arthritis in mice." Mediators of Inflammation 11, no. 2 (2002): 75–79. http://dx.doi.org/10.1080/09629350220131917.

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The anti-inflammatory effect of microalgae Spirulina was studied in zymosan-induced arthritis in mice. Four days after the intra-articular injection of zymosan (15 mg/ml), Spirulina (100 and 400 mg/kg per-orally) was administered to animals for 8 days. The mice were than killed and β-glucuronidase was measured in the synovial fluid. Each knee joint was totally removed for histopathological studies. Spirulina significantly reduced the levels of β-glucuronidase that had been increased by zymosan. Histopathological and ultrastructural studies showed inhibition of the inflammatory reaction, wherea

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Baek, Jin Seon, Younhee Nam, Sunghee Kim, et al. "Development of Low-Caffeine Kombucha Using Lotus Root Tea and an Evaluation of Its Functional Properties." Beverages 11, no. 2 (2025): 55. https://doi.org/10.3390/beverages11020055.

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Kombucha, traditionally fermented from black or green tea, is well known for its potential health benefits. However, its high caffeine content may limit consumption for certain individuals. Therefore, this study aimed to develop a low-caffeine kombucha using lotus root tea as an alternative to black or green tea. Lotus root was roasted and brewed to prepare the tea base, to which sugar and a SCOBY were added for primary fermentation. Subsequently, Lactobacillus plantarum (1.0 × 109 and 3.0 × 109 CFU/mL) was inoculated to carry out secondary fermentation. The kombucha samples were assessed for

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Wang, Panpan, Yifei Jia, Rongrong Wu, Zhiqiang Chen та Ru Yan. "Human gut bacterial β-glucuronidase inhibition: An emerging approach to manage medication therapy". Biochemical Pharmacology 190 (серпень 2021): 114566. http://dx.doi.org/10.1016/j.bcp.2021.114566.

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31

Taha, Muhammad, Nor Hadiani Ismail, Syahrul Imran та ін. "Synthesis, β-glucuronidase inhibition and molecular docking studies of hybrid bisindole-thiosemicarbazides analogs". Bioorganic Chemistry 68 (жовтень 2016): 56–63. http://dx.doi.org/10.1016/j.bioorg.2016.07.008.

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de Lange, Pieter, Gert-Jan de Boer, Joseph N. M. Mol та Jan M. Kooter. "Conditional inhibition of β-glucuronidase expression by antisense gene fragments in petunia protoplasts". Plant Molecular Biology 23, № 1 (1993): 45–55. http://dx.doi.org/10.1007/bf00021418.

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Hayat, Ullah, Khan Fahad, Rahim Fazal, et al. "Synthesis and Molecular Docking Study of bis-thiobarbiturate Derivatives as Effective Inhibitors of beta-glucuronidase." Journal of Ongoing Chemical Research 4, no. 2 (2019): 32–36. https://doi.org/10.5281/zenodo.3576583.

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 Bis-thiobarbiturate derivatives 1-15 have been synthesized and evaluated for their  in vitro β-glucuronidase inhibitory potential. The structures of all compounds were confirmed through spectroscopic techniques such as EI-MS and 1HNMR. Compounds 13 (IC50 = 29.42 ± 0.61 μM) showed potent β-glucuronidase inhibitory potential better than the standard inhibitor (D-saccharic acid 1, 4 lactone, IC50 = 48.4 ± 1.25  μM). The compounds 2 (IC50 = 48.45 ± 0.39  μM), 3 (IC50 = 53.12 ± 0.22  μM), 4 (IC50 = 55.12

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Sun, Cheng-Peng, Xiang-Ge Tian, Lei Feng та ін. "Inhibition of gut bacterial β-glucuronidase by chemical components from black tea: Inhibition interactions and molecular mechanism". Arabian Journal of Chemistry 14, № 12 (2021): 103457. http://dx.doi.org/10.1016/j.arabjc.2021.103457.

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Abousaab, Abeer, Jamshed Warsi, Madhuri S. Salker та Florian Lang. "β-Klotho as a Negative Regulator of the Peptide Transporters PEPT1 and PEPT2". Cellular Physiology and Biochemistry 40, № 5 (2016): 874–82. http://dx.doi.org/10.1159/000453146.

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Background/Aims: β-Klotho, a transmembrane protein expressed in several tissues including the brain and the kidney, is critically important for inhibition of 1,25(OH)2D3 formation by FGF23. The extracellular domain of Klotho protein could be cleaved off, thus being released into blood or cerebrospinal fluid. Soluble klotho is a β-glucuronidase participating in the regulation of several ion channels and carriers. The present study explored the effect of β-Klotho protein on the peptide transporters PEPT1 and PEPT2. Methods: cRNA encoding PEPT1 or PEPT2 was injected into Xenopus laevis oocytes an

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Zhong, Shu-shu, Jun Zhang, Ze-hua Liu, Zhi Dang та Yu Liu. "Inhibition Properties of Arylsulfatase and β-Glucuronidase by Hydrogen Peroxide, Hypochlorite, and Peracetic Acid". ACS Omega 6, № 12 (2021): 8163–70. http://dx.doi.org/10.1021/acsomega.0c06060.

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Kamel, Emadeldin M., Haifa A. Alqhtani, May Bin-Jumah, Hassan A. Rudayni, Ashraf A. El-Bassuony та Al Mokhtar Lamsabhi. "Deciphering molecular mechanisms underlying the inhibition of β-glucuronidase by xanthones from Centaurium spicatum". Bioorganic Chemistry 150 (вересень 2024): 107609. http://dx.doi.org/10.1016/j.bioorg.2024.107609.

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Nile, Shivraj H., and Chandrahasy N. Khobragade. "In Vitro Anti-inflammatory and Xanthine Oxidase Inhibitory Activity of Tephrosia purpurea Shoot Extract." Natural Product Communications 6, no. 10 (2011): 1934578X1100601. http://dx.doi.org/10.1177/1934578x1100601006.

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The methanolic extract of Tephrosia purpurea (Leguminosae) shoots was evaluated in-vitro for its anti-inflammatory and xanthine oxidase inhibitory activity. Anti-inflammatory activity was measured by the Diene-conjugate, HET-CAM and β-glucuronidase methods. The enzyme inhibitory activity was tested against isolated cow milk xanthine oxidase. The average anti-inflammatory activity of T. purpurea shoot extract in the concentration range of 1-2 μg/mL in the reacting system revealed significant anti-inflammatory activities, which, as recorded by the Diene-conjugate, HET-CAM and β-glucuronidase ass

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Cheng, Kai-Wen, Chih-Hua Tseng, I. Ju Chen та ін. "Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis". Pharmacological Research 177 (березень 2022): 106115. http://dx.doi.org/10.1016/j.phrs.2022.106115.

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Prakash, A. O., та Sandhya Pathak. "Inhibition of β-Glucuronidase Activity in Rat Uterus During Implantation by Feeding Ferula jaeschkeana Extract". International Journal of Pharmacognosy 32, № 4 (1994): 362–65. http://dx.doi.org/10.3109/13880209409083016.

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Lin, Chu-Hung, Hsiao-Jung Chou, Chih-Chi Chang та ін. "Chemical Constituent of β-Glucuronidase Inhibitors from the Root of Neolitsea acuminatissima". Molecules 25, № 21 (2020): 5170. http://dx.doi.org/10.3390/molecules25215170.

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Neolitsea acuminatissima (Lauraceae) is an endemic plant in Taiwan. One new carboline alkaloid, demethoxydaibucarboline A (1), two new eudesmanolide-type sesquiterpenes, methyl-neolitacumone A (2), neolitacumone E (3), and twelve known compounds (4–15) were isolated from the root of Neolitsea acuminatissima. Their structures were elucidated by spectroscopic analysis. Glucuronidation represents a major metabolism process of detoxification for carcinogens in the liver. However, intestinal bacterial β-Glucuronidase (βG) has been considered pivotal to colorectal carcinogenesis. To develop specific

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Sacco, C., W. E. McEwen та E. J. Calabrese. "Selective Inhibition of Gastrointestinal β-Glucuronidase by Polyvinylbenzyl D-glucaro(1,4)lactonate: Attachment of D-Glucaro(1,4)lactone to Polyvinylbenzyl Chloride". Human & Experimental Toxicology 12, № 2 (1993): 181–84. http://dx.doi.org/10.1177/096032719301200216.

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D-Glucaro(1,4)lactone, a potent β-glucuronidase inhibitor was attached via the carboxylic acid moiety to polyvinylbenzyl chloride (PVBC) using a bimolecular nucleophilic displacement reaction, First, the caesium salt of D-glucaro(1,4)lactone was prepared by titrating the carboxylic acid to neutrality with aqueous caesium bicarbonate. The polyvinylbenzyl D-glucaro(1,4)lactonate was obtained in maximum yields of between 50 and 60% when caesium D-glucaro(1,4)lactonate was incubated with PVBC in DMF at 50°C for 7 d in the presence of a catalyst, caesium iodide.

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Kh.R., Rustamova. "The Effect of Compounds Belonging Acylhydrazides Schiff Bases of Indol Classes and Sulphones Classes on β-Glucuronidase (In Vitro Research)". Journal of Life Sciences and Biomedicine 64, № 5-6 (2009): 14–19. https://doi.org/10.5281/zenodo.7484145.

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12 compounds from acylhydrazides schiff bases of indol classes and 7 compounds from sulphones classes were screened for β-glucuronidase and were determined IC50 (concentration of compound which can inhibit 50 % activity of enzyme). 5 compounds of 12 had not activity, 6 had good activity with compare standard inhibitor (D-saccharic acid 1,4-lacton 48.4± 1.25µl) and 1 has weak activity, while 1 compound is very potent inhibitor from sulphones classes. Comparison between compounds belonging two classes shows if there are halogens in the compounds then this compounds is good inhi

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AO, ASANGLA, ROBERT P. ERICKSON, ARTURO BEVILACQUA та JILL KAROLYI. "Antisense Inhibition of β-Glucuronidase Expression in Preimplantation Mouse Embryos: A Comparison of Transgenes and Oligodeoxynucleotides". Antisense Research and Development 1, № 1 (1991): 1–10. http://dx.doi.org/10.1089/ard.1991.1.1.

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Taha, Muhammad, Nizam Uddin, Muhammad Ali та ін. "Inhibition potential of phenyl linked benzimidazole-triazolothiadiazole modular hybrids against β-glucuronidase and their interactions thereof". International Journal of Biological Macromolecules 161 (жовтень 2020): 355–63. http://dx.doi.org/10.1016/j.ijbiomac.2020.06.006.

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Fujikawa, Yasuhiro, Tetsuo Satoh, Akiyoshi Suganuma, et al. "Extremely sensitive biomarker of acute organophosphorus insecticide exposure." Human & Experimental Toxicology 24, no. 6 (2005): 333–36. http://dx.doi.org/10.1191/0960327105ht532oa.

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Egasyn-βglucuronidase complex is located at the luminal site of liver microsomal endoplasmic reticulum. When organophosphorus insecticides (OP) are incorporated into the liver microsomes, they become tightly bound to egasyn, a carboxylesterase isozyme, and subsequently, β-glucuronidase (BG) is dissociated and released into blood. Consequently, the increase in plasma BG activity becomes a good biomarker of OP exposure. Thus, the single administration of EPN (O-ethyl O-p-nitrophenylphenylphosphonothioate), acephate and chlorpyrifos increased plasma BG activity in approximately 100-fold the contr

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Parashar, S., V. Uplanchiwar, R. K. Gautam, and S. Goyal. "IN VITRO ANTIOXIDANT AND IN VIVO HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF ZIZIPHUS RUGOSA LAM. LEAVES." INDIAN DRUGS 56, no. 07 (2019): 69–75. http://dx.doi.org/10.53879/id.56.07.11577.

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Ziziphus rugosa Lam. belongs to the family Rhamnaceae and is found chiefly in deciduous and semi evergreen forest of Western Ghats. The present research was undertaken to establish in vitro antioxidant and in vivo hepatoprotective activity of ethanolic extract of Z.rugosa Lam. leaves. The powdered leaves of Z. rugosa were extracted with ethanol and preliminary phytochemical screening was performed for the presence of various phytoconstituents. DPPH assay and β-glucuronidase inhibition assay were selected for the free radical scavenging activity. For the assessment of hepatoprotective activity,

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Cheng, Kai-Wen, Chih-Hua Tseng, Cherng-Chyi Tzeng та ін. "Pharmacological inhibition of bacterial β-glucuronidase prevents irinotecan-induced diarrhea without impairing its antitumor efficacy in vivo". Pharmacological Research 139 (січень 2019): 41–49. http://dx.doi.org/10.1016/j.phrs.2018.10.029.

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Hanif, Muhammad, Imtiaz Khan, Nasim Hasan Rama та ін. "Synthesis, crystal structure and β-glucuronidase inhibition activity of some new hydrazinecarboxamides and their 1,2,4-triazole derivatives". Medicinal Chemistry Research 21, № 11 (2011): 3885–96. http://dx.doi.org/10.1007/s00044-011-9929-1.

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Chou, Chung-Tei, and Sheng-Chu Kuo. "The Anti-inflammatory and Anti-hyperuricemic Effects of Chinese Herbal Formula Danggui-Nian-Tong-Tang on Acute Gouty Arthritis: A Comparative Study with Indomethacin and Allopurinol." American Journal of Chinese Medicine 23, no. 03n04 (1995): 261–71. http://dx.doi.org/10.1142/s0192415x95000316.

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The traditional Chinese antirheumatic herb Danggui-Nian-Tong-Tang (DGNTT) was studied comparatively with indomethacin and allopurinol to evaluate its anti-inflammatory and antihyperuricemic effects in patients with gout. Results in this study did not show any significant improvement in reducing the total number of painful and swollen joints, articular index and pain score ( P > 0.05) by treatment with DGNTT. Unlike allopurinol, DGNTT did not lower the high serum level of uric acid. In vitro study in rats showed that DGNTT significantly inhibits the activity of β-glucuronidase ( P < 0.05)

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