Academic literature on the topic 'Β-nitrostyrene'

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Journal articles on the topic "Β-nitrostyrene"

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Lissovskaya, L., E. Gorin, I. Korol’kov, and S. Dosmagambetova. "Synthesis and some transformations of carboranyl-containing nitroalkanes." BULLETIN of the L.N. Gumilyov Eurasian National University. Chemistry. Geography. Ecology Series 132, no. 3 (2020): 52–60. http://dx.doi.org/10.32523/2616-6771-2020-132-3-52-60.

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he article presents the reactions of the addition of C-metal derivatives of carboranes with β - nitrostyrene: p-dimethylamino-β-nitrostyrene, β - nitrostyrene, 2,5 - dimethoxy-β-nitrostyrene, 3,4,5 - trimethoxy-Синтез и некоторые превращения карборанилсодержащих нитроалканов 59β-nitrostyrene . The reactions of the interaction of these compounds with C-metal derivatives of carboranes were studied. The following compounds were synthesized: isopropyl-o-carborane – β – nitrostyrene, isopropyl-o-carborane –3,4,5-trimethoxy – β – nitrostyrene, isopropyl-o-carborane-2,5-dimethoxy-β-nitrostyrene, isop
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Safaei, Elham, Sara Sobhani, and Nasrin Razavi. "Efficient synthesis of 2-indolyl-1-nitroalkanes catalyzed by tetramethyl-tetra-3,4-pyridinoporphyrazinato copper(II) methyl sulfate." Journal of Porphyrins and Phthalocyanines 16, no. 02 (2012): 227–34. http://dx.doi.org/10.1142/s1088424612004549.

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A new method for the synthesis of 2-indolyl-1-nitroalkanes from indoles and β-nitrostyrene via Michael addition catalyzed by [ Cu (3,4-tmtppa)] (MeSO4)4 as a reusable catalyst under solvent-free conditions is described. This method has been also successfully applied for Michael addition of 3-methyl-1-phenyl-5-pyrazolone with β-nitrostyrenes.
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D’Andrea, Laura, та Simon Jademyr. "Facile one-pot reduction of β-nitrostyrenes to phenethylamines using sodium borohydride and copper(II) chloride". Beilstein Journal of Organic Chemistry 21 (7 січня 2025): 39–46. https://doi.org/10.3762/bjoc.21.4.

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Phenethylamines and phenylisopropylamines of scientific relevance can be prepared with a NaBH4/CuCl2 system in 10 to 30 minutes via reduction of substituted β-nitrostyrenes. This one-pot procedure allows the quick isolation of substituted β-nitrostyrene scaffolds with 62–83% yield under mild conditions, without the need for special precautions, inert atmosphere, and time-consuming purification techniques.
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Wang, Yen-Yun, Pei-Wen Hsieh, Yuk-Kwan Chen, et al. "CYT-Rx20 Inhibits Cervical Cancer Cell Growth and Migration Through Oxidative Stress-Induced DNA Damage, Cell Apoptosis, and Epithelial-to-Mesenchymal Transition Inhibition." International Journal of Gynecologic Cancer 27, no. 7 (2017): 1306–17. http://dx.doi.org/10.1097/igc.0000000000001033.

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ObjectiveThe β-nitrostyrene family has been reported to possess anticancer properties. However, the anticancer activity of β-nitrostyrenes on cervical cancer cells and the underlying mechanisms involved remain unexplored. In this study, a β-nitrostyrene derivative CYT-Rx20 (3′-hydroxy-4′-methoxy-β-methyl-β-nitrostyrene) was synthesized, and its anticancer activity on cervical cancer cells and the mechanisms involved were investigated.MethodsThe effect of CYT-Rx20 on human cervical cancer cell growth was evaluated using cell viability assay. Reactive oxygen species (ROS) generation and annexin
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Komala, Ismiarni, Supandia, Nurhasnib та ін. "Microwave Assisted Synthesis of p-Methoxycinnamamides and p-Methoxy-β-nitrostyrenes from Ethyl p-methoxycinnamate and Screening their Anti-inflammatory Activity". Natural Product Communications 12, № 8 (2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200830.

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A new modification reaction of ethyl p-methoxycinnamate (1) to afford a series of p-methoxycinnamamide and p-methoxy-β-nitrostyrene has been developed by using the assistance of the unmodified microwave oven. The synthesized compounds were characterized by using various spectroscopic techniques and furthermore screened for their anti-inflammatory activity by using anti-denaturation of heat bovine serum albumin (BSA) method. The result of bioassay indicated that p-methoxycinnamamide derivatives and p-methoxy-β-nitrostyrenes showed interesting anti-inflammatory activity.
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Itoh, Kuniaki, Shigehisa Kishimoto та Kazuo Sagi. "Novel formation of isoxazoline N-oxide in addition to Michael adduct from the reaction of β-nitrostyrenes with 2-methoxyfuran — Experimental and theoretical studies". Canadian Journal of Chemistry 87, № 6 (2009): 760–74. http://dx.doi.org/10.1139/v09-068.

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2-Methoxyfuran reacts with β-nitrostyrenes to give Michael adducts. Interestingly, isoxazoline N-oxides were obtained in the reactions with β-nitrostyrenes possessing additional electron-withdrawing groups [COPh (2f) and CO2Et (2g)]. (Z)-Nitrostyrene (2g) gives trans-isoxazoline (4g) and (E)-nitrostyrene (2f) leads to the cis-form product 4f. We have used theoretical methods to investigate the mechanism and to probe the regio- and stereo-selectivity observed in the rearrangement and the Michael reactions. To account for the selectivity observed in these reactions, we examined the Fukui functio
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Alfarisi, Salman, Mardi Santoso, Alfinda Novi Kristanti, Imam Siswanto та Ni Nyoman Tri Puspaningsih. "Synthesis, Antimicrobial Study, and Molecular Docking Simulation of 3,4-Dimethoxy-β-Nitrostyrene Derivatives as Candidate PTP1B Inhibitor". Scientia Pharmaceutica 88, № 3 (2020): 37. http://dx.doi.org/10.3390/scipharm88030037.

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A derivative series of 3,4-dimethoxy-β-nitrostyrene was synthesized through nitroaldol reaction, including a new compound of 3,4-ethylenedioxy-β-bromo-β-nitrostyrene. The antimicrobial activity effect of 3,4-alkyloxy modification of β-nitrostyrene was investigated. A molecular docking study was also performed to obtain information about their interactions with protein tyrosine phosphatase 1B (PTP1B). The active residues of cysteine-215 and arginine-221 of PTP1B play a key role in signaling pathways that regulate various microorganism cell functions. It also acts as a negative regulator in sign
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Pomarański, Piotr, and Zbigniew Czarnocki. "l-Prolinal Dithioacetal: A Highly Effective Organocatalyst for the Direct Nitro-Michael Addition to Selected Cyclic and Aromatic Ketones." Synthesis 51, no. 17 (2019): 3356–68. http://dx.doi.org/10.1055/s-0037-1611531.

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The synthesis of novel l-prolinal dithioacetal and its application as an organocatalyst for the direct Michael addition of cyclic ketones and acetophenone derivatives to trans-β-nitrostyrene and related compounds is described. The prolinal dithioacetal acts as effective catalyst in the case of cyclic ketones of different ring size, in particular five- and six-membered examples, as well as larger and smaller ring systems. High enantioselectivity and diastereoselectivity is observed for different substrates and trans-β-nitrostyrenes. Also, the first asymmetric syntheses of selected 2-methyl-4-ni
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Iwai, Kento, Khimiya Wada та Nagatoshi Nishiwaki. "Unusual Reactivities of ortho-Hydroxy-β-nitrostyrene". Molecules 27, № 15 (2022): 4804. http://dx.doi.org/10.3390/molecules27154804.

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Nitrostyrene derivatives are widely used in organic syntheses as a substrate for Michael addition, photoisomerization and cycloaddition. In contrast, ortho-hydroxy derivatives exhibit unusual behaviors in these reactions. Conjugate addition proceeded upon treatment of the ortho-hydroxy-β-nitrostyrene with an amine; however, subsequent C–C bond cleavage readily occurred to afford the corresponding imine. Moreover, conversion of the trans-isomer to a cis-isomer did not occur efficiently, even when UV light was irradiated. We studied these unusual behaviors of β-nitrostyrene, focusing on the role
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Hamdellou, Lamine, Olivier Hernandez та Jean Meinnel. "4-Dimethylamino-β-nitrostyrene and 4-dimethylamino-β-ethyl-β-nitrostyrene at 100 K". Acta Crystallographica Section C Crystal Structure Communications 62, № 9 (2006): o557—o560. http://dx.doi.org/10.1107/s0108270106025819.

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Dissertations / Theses on the topic "Β-nitrostyrene"

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Lombardi, Federico. "Computational study on the asymmetric aminocatalysed Michael addition reaction of cyclohexanone to trans–β–nitrostyrene". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amslaurea.unibo.it/23186/.

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Asymmetric organocatalysed reactions are one of the most fascinating synthetic strategies which one can adopt in order to induct a desired chirality into a reaction product. From all the possible practical applications of small organic molecules in catalytic reaction, amine–based catalysis has attracted a lot of attention during the past two decades. The high interest in asymmetric aminocatalytic pathways is to account to the huge variety of carbonyl compounds that can be functionalized by many different reactions of their corresponding chiral–enamine or –iminium ion as activated nucleophile a
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林威丞. "Allylation Reaction of β-Nitrostyrene in Water". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/36010308944235782538.

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碩士<br>國立彰化師範大學<br>化學系<br>101<br>Nitroalkenes are known to be excellent Michael acceptors in conjugate addition reactions with organometallic reagents that are prepared in situ from allylic bromides and metals. Until now, no reports exist describing the use of nitroalkenes as surrogates for carbonyl compounds in metal-mediated Barbier type allylation reactions. Here, a simple and practical approach has been developed for conducting direct, homoallylic alcohol forming allylation reactions of nitroalkenes in water. Employing the new method, various arylmethyl-homoallylic alcohols can be p
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Lee, Chih Hsun, та 李治勳. "The in vivo Evaluations of Anti-inflammatory β-Nitrostyrene Derivatives". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/d7hew3.

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Chang, Yu Ting, та 張育婷. "Synthesis and evaluation of β-nitrostyrene derivatives as anti-platelet aggregation agents". Thesis, 2009. http://ndltd.ncl.edu.tw/handle/40264486003442294594.

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碩士<br>長庚大學<br>天然藥物研究所<br>97<br>In previous studies, 3,4-methylenedioxy-β-nitrostyrene (MNS) and 4-O-benzoyl-3-methoxyl-β-nitrostyrene (BMNS) exhibited inhibitory effector platelet aggregation via suppression of tyrosine kinases (Src and Syk). Furthermore, BMNS possessed 8 times greater potency than MNS, and 100 times greater potency than non-selective tyrosine kinases inhibitors (genistein and tyrphostin A47) in inhibiting thrombin-induced pletlet aggregation. Accordingly, β-nitrostyrenes derivatives were be as potential anti-platelet aggregation agent. In order to research and develop potent
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Lu, Fen Hua, та 盧芬華. "The Synthesis and Bioactive Evaluation of 4-O-Benzoyl-3-Methoxy-β-Nitrostyrene Analogs". Thesis, 2012. http://ndltd.ncl.edu.tw/handle/22903202222542840962.

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碩士<br>長庚大學<br>中醫學系天然藥物<br>100<br>Neutrophil overactivation is a common pathogenesis of acute and chronic inflammatory diseases including asthma, acute lung injury, chronic obstructive pulmonary disease and cancer. So far, the drugs which treated those diseases are not widespread in clinical use. In this study, we clarified the effects of 4-O-benzoyl-3-methoxy-β-nitrostyrene (BMNS) analogs on human neutrophil activation, and also discussed the relationship between chemical structures of these compounds and their biological activity. We synthesized 25 BMNS analogs and examined their effects on s
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Wu, Ming-Fun, та 吳明峰. "1.Organocatalytic enantioselective [3+3] and [4+2] annulation of ?β-unsaturated aldehyde2.Organocatalytic double Michael and Michael-Henry reaction of aldehydes and β-nitrostyrene". Thesis, 2008. http://ndltd.ncl.edu.tw/handle/07414088361779357400.

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博士<br>國立中正大學<br>化學所<br>97<br>In chapter one, we describe the highly enantioselective organocatalyzed carbo [3 + 3] cycloaddition and [4 + 2] annulation of ?β-unsaturated aldehydes. The structure of the [3 + 3] adduct was confirmed by X-ray analysis of adduct. The [4 + 2] Robinson annulation catalyzed by L-proline and trialkylamines or diarylpyrrolinol silyl ethers afforded the adducts with high enantioselectivity (>99.5% e.e.). The structures of the [4 + 2] adducts obtained from the reaction of 4-oxobut-2-enyl acetate and (E)-3- (2-nitrophenyl)acrylaldehyde were not only confirmed by X-ray an
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Lin, Yu-Min, та 林玉敏. "The Study of Inhibitory Effect of β-nitrostyrene derivatives HNEB from Morus australis Poir. on GPVI-mediated Platelet Activation". Thesis, 2013. http://ndltd.ncl.edu.tw/handle/58270283590631974043.

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碩士<br>國立陽明大學<br>藥理學研究所<br>101<br>Platelet dysfunction is a major risk factor of cardiovascular diseases such as acute coronary syndrome (ACS), atherosclerosis, and stroke. The anti-platelet therapy is a well-established part of the treatment of cardiovascular arterial disease. However, there remain considerable side effects of current anti-platelet drugs. Therefore, it is necessary to look for other therapeutic strategies. GPVI is a collagen receptor, which plays a critical role in initial platelet activation. To date, the anti-GPVI drugs have not been developed. Previous study showed that los
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Chen, I.-Hua, та 陳懿華. "Studies on the anti-metastatic effects and mechanisms of action of 3,4-methylenedioxy-β-nitrostyrene in triple-negative breast cancer cells". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/gzvgez.

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博士<br>高雄醫學大學<br>天然藥物研究所博士班<br>103<br>Triple negative breast cancer (TNBC) exhibits an aggressive clinical course by high metastatic potential. It is known that integrin-mediated cell adhesion and migration are important for cancer metastasis. In the present study, a synthetic compound, 3, 4-methyenedioxy-β-nitrostyrene (MNS), significantly inhibited adhesion of TNBC cell lines to different extracellular matrix (ECM) components. The antimetastatic capacity of MNS was also observed through reducing TNBC cells migration and invasion without affecting cell viability. Confocal microscopy revealed t
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Wei, Chien-Kai, та 魏千凱. "Inhibition of tumor cell-induced platelet activation andaggregation by β-nitrostyrenes". Thesis, 2008. http://ndltd.ncl.edu.tw/handle/02286942936818763477.

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碩士<br>高雄醫學大學<br>天然藥物研究所<br>96<br>Many types of tumor cells have the ability to aggregate blood platelets and, tumor cell-induced platelet aggregation (TCIPA) has been shown to play an important role in cancer metastasis. Therefore, it is possible that blockade of tumor cell-platelet interactions may help to inhibit tumor progression. In the present study, we have tested two novel inhibitors of tyrosine kinases: 3,4-methylene-dioxy-??-nitrostyrene (MNS) and 4-O-benzoyl-3-methoxyl-??- nitrostyrene (BMNS) for their inhibitory effect on TCIPA caused by MDA-MB-231 cells, which are highly metastatic
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Liu, Ju-Tsung, та 柳如宗. "Ⅰ.Reactions of β-Nitrostyrenes with Organoboranes or Grignard Reagents Ⅱ.Amphetamines Analysis by GC-MS". Thesis, 2001. http://ndltd.ncl.edu.tw/handle/90522896343381382566.

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博士<br>國立臺灣師範大學<br>化學研究所<br>89<br>Reaction of β-nitrostyrenes with trialkylboranes under nitrogen to generate alkenes in high yields. The mechanism is proposed to be a free-radical reaction via NO2/ alkyl substitution since the reaction is stimulated by the presence of a trace of oxygen in the nitrogen or tert-butyl peroxide or by photolysis and is retarded or inhibited by the addition of galvinoxyl. Reactions of β-nitrostyrenes and triethylborane or tricyclohexylborane in THF solution at room temperature in the air produce trans-alkenes in high yields. Fair good yields of various (
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Book chapters on the topic "Β-nitrostyrene"

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Alfarisi, Salman, Mardi Santoso, Alfinda Novi Kristanti, Imam Siswanto, and Ni Nyoman Tri Puspaningsih. "Synthesis, Antimicrobial Study, and Molecular Docking Simulation of 3,4-Dimethoxy-β-Nitrostyrene Derivatives as Candidate PTP1B Inhibitor." In Statistical Inference for Ergodic Algorithmic Model (EAM), Applied to Hydrophobic Hydration Processes. Vide Leaf, Hyderabad, 2021. http://dx.doi.org/10.37247/up.1.22.30.

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Martins, Daniel, Joana Reis, Fernanda Borges, and Nuno Milhazes. "4.2.2.6. Preparation of a β-Nitrostyrene Derivative by the Henry Reaction: Comparison of a Conventional and a Microwave-Assisted Method." In Comprehensive Organic Chemistry Experiments for the Laboratory Classroom. The Royal Society of Chemistry, 2016. http://dx.doi.org/10.1039/9781849739634-00348.

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Conference papers on the topic "Β-nitrostyrene"

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Abdullah, Noraishah, Zurina Shaameri, Ahmad Sazali Hamzah та Mohd Fazli Mohammat. "Asymmetric michael addition of cyclohexanones to trans-β-nitrostyrene catalyzes by prolineamide-based organocatalyst". У INTERNATIONAL CONFERENCE ON APPLIED COMPUTATIONAL INTELLIGENCE AND ANALYTICS (ACIA-2022). AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0127594.

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Kobayashi, Hideki, Hirohisa Kanbara, Ken'ichi Kubodera, and Yoshito Shuto. "A picosecond optical-Kerr-shutter switch using an organic solution in a capillary waveguide." In Integrated Photonics Research. Optica Publishing Group, 1991. http://dx.doi.org/10.1364/ipr.1991.tue4.

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Optically-controlled optical switches will be key elements in time-division multiplexing devices for future optical communication and computing systems. Glass fibers have been applied to such switches1 utilizing easy fabrication of long interaction length and small core diameter in fibers, however, their optical nonlinearities are quite small. Organic nonlinear optical materials have been applied to efficient optical switches.2,3 In this paper, an even more efficient, high-speed optical- Kerr-shutter switch is demonstrated using a recently-synthesized organic material, 4-(N,N-diethylamino)-β-n
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