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Journal articles on the topic 'ΒHCG'

Author: Grafiati
Published: 7 June 2025
Last updated: 2 August 2025

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1

Syrigos, K. N., I. Fyssas, M. M. Konstandoulakis, et al. "Beta human chorionic gonadotropin concentrations in serum of patients with pancreatic adenocarcinoma." Gut 42, no. 1 (1998): 88–91. http://dx.doi.org/10.1136/gut.42.1.88.

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Background—Human chorionic gonadotropin (hCG) is normally produced and secreted by trophoblastic cells during pregnancy and from gestational trophoblastic neoplasms. It is also detected in ovarian, stomach, and colon adenocarcinomas, as well as in squamous cell carcinoma of the oesophagus. Recently, interest in its role in the pathogenesis of tumours has been enlivened after the presence of βhCG in the cell membrane of several malignant cells was shown in vitro.Aims—To investigate the circulating concentrations of βhCG in patients with exocrine pancreatic adenocarcinoma and to examine its pote
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2

Brousse, Mehdi, Anne-Sophie Bargnoux, Caroline Courtais-Coulon, et al. "Optimization of Patient Management in the Gynecology Emergency Department Using Point-of-Care Beta hCG." Diagnostics 12, no. 7 (2022): 1670. http://dx.doi.org/10.3390/diagnostics12071670.

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Background: Point-of-care testing (POCT) provides shorter turn-around times and, in many cases, potentially improves medical decision making. The AQT90 FLEX® benchtop immunoanalyzer (Radiometer Medical ApS, Copenhagen, Denmark) allows for the determination of beta-human chorionic gonadotropin (βhCG) in 18 min. The main aim of this study was to evaluate the impact of measuring βhCG using the AQT90 analyzer in the gynecology emergency department (ED) compared to the standard practice of using central laboratory blood testing on the patient length of stay (LOS). Methods: The evaluation consisted
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3

S., Priyadarsini, та Gigi A. "Correlation between β-HCG and Doppler in post molar surveillance". International Journal of Reproduction, Contraception, Obstetrics and Gynecology 7, № 5 (2018): 1836. http://dx.doi.org/10.18203/2320-1770.ijrcog20181913.

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Background: Gestational trophoblastic disease encompass a spectrum of neoplastic disorders that arise from placental trophoblastic tissue after abnormal fertilisation. Most molar pregnancies spontaneously resolve after uterine evacuation with no further sequelae. However, at any time during or after gestation malignant transformation may occur in approximately 10% to 20% of molar pregnancies. Quantification of βHCG is considered as the ideal method of post molar surveillance. The regression of the disease could be reliably assessed by observing the changes in low resistance flow which parallel
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4

Dilberović, Admir, Ana Stanić, and Mirela Zec. "Diagnostic significance of human chorionic gonadotropin as a tumor marker." Hrvatski časopis zdravstvenih znanosti 3, no. 2 (2023): 136–41. http://dx.doi.org/10.48188/hczz.3.2.3.

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Cilj: Cilj ovog rada bio je odrediti pouzdanost metode za određivanje koncentracije beta podjedinice humanog korionskog gonadotropina (βhCG) i dijagnostički značaj βhCG u krvi kod pacijenata s karcinomom testisa.Metode: Ispitivanje je uključilo 10 pacijenata muškog spola s potvrđenom dijagnozom karcinoma testisa i 10 pacijenata koji nemaju dijagnozu kao kontrolnu skupinu. Vrijednosti izmjerenih koncentracija prikupljene su iz arhive te su potom interpretirane u skladu s ostalom medicinskom dokumentacijom. Metoda istraživanja bila je retrospektivna deskriptivna analiza. U svih ispitanika koncen
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5

Tran, Dinh Vinh, Thi Phuong Le Nguyen та Thi Minh Huong Pham. "Giá trị tiên lượng của β-hCG sau 14 ngày chuyển phôi trong chửa đa thai ở bệnh nhân thụ tinh ống nghiệm". Tạp chí Phụ sản 16, № 2 (2018): 108–13. http://dx.doi.org/10.46755/vjog.2018.2.517.

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Mục tiêu nghiên cứu: (1) Xác định nồng độ βhCG huyết thanh ngày thứ 14 sau chuyển phôi trong tiên lượng số phôi làm tổ trong buồng tử cung; (2) Nhận xét một số yếu tố liên quan đến chửa đa thai trong thụ tinh ống nghiệm.
 Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả hồi cứu trên 189 bệnh nhân thực hiện thụ tinh trong ống nghiệm – chuyển phôi tại Bệnh viện Phụ sản – Nhi Đà Nẵng từ 03/2016 – 8/2017 có nồng độ βhCG ngày thứ 14 sau chuyển phôi ≥ 25 mIU/mL và siêu âm thấy có túi thai trong buồng tử cung sau thử βhCG 3 tuần.
 Kết quả nghiên cứu: Nồng độ βhCG trung bình sau chuyển
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6

Beaman, Janine M., Naheed Akhtar та David J. Goldie. "Down's Syndrome Screening Using Free βhCG: Instability Can Significantly Increase the Down's Risk Estimate". Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 33, № 6 (1996): 525–29. http://dx.doi.org/10.1177/000456329603300606.

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The stability of free βhCG (human chorionic gonadotrophin) was assessed using a dual α-fetoprotein and free βhCG assay. A significant increase in free βhCG concentration was observed in heparinized samples left unseparated for 24 h or more, the mean increase in 21 samples being 10.2% after 24 h ( P = < 0.001), increasing to 45.7% after 96 h. Similar results were also obtained in clotted samples. The effect of the increase in free βhCG on the Down's risk estimate was calculated to assess the impact of delayed sample transport and separation. The Down's risk increased in all samples with incr
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7

Devasia, Neena, та Tinu Philip. "A study of factors affecting regression of βhCG in gestational trophoblastic disorders". International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, № 3 (2019): 955. http://dx.doi.org/10.18203/2320-1770.ijrcog20190864.

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Background: Gestational trophoblastic disorders are among the rare human tumors that can be cured even in the presence of widespread dissemination. Authors can anticipate the development of persistent trophoblastic disease by identifying high risk factors affecting βhCG regression in vesicular mole. The study of this aim was to determine the incidence of gestational trophoblastic disorders and persistent trophoblastic disease in our institution. Factors affecting regression of βhCG and thereby leading to persistent disease are assessed.Methods: The study was conducted for a period of 2 years a
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8

Phan, Kieu Linh, та Minh Tam Le. "Predictive value of βhCG measured on day 11 after blastocyst embryo transfer for early pregnancy outcome". Tạp chí Phụ sản 21, № 1 (2023): 80–87. http://dx.doi.org/10.46755/vjog.2023.1.1557.

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Objectives: To study the value of βhCG on day 11 after embryo transfer in predicting the early outcome of pregnancy after in vitro fertilization.
 Materials and methods: A prospective descriptive study was examined on 148 cycles that satisfied inclusion criteria that the βhCG concentration at day 11 after IVF was higher or equal to 25mIU/ml. This research was conducted at Hue center for Reproductive Endocrinology and Infertility from December 2019 to July 2022. The cycles that met the inclusion criteria were followed up to 12 weeks of gestation. Comparing the variation of the βhCG level b
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9

Seregni, E., M. Massimino, S. Nerini Molteni, et al. "Serum and Cerebrospinal Fluid Human Chorionic Gonadotropin (hCG) and alpha-fetoprotein (AFP) in Intracranial Germ Cell Tumors." International Journal of Biological Markers 17, no. 2 (2002): 112–18. http://dx.doi.org/10.1177/172460080201700206.

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We report a retrospective study on serum and cerebrospinal fluid (CSF) alpha-fetoprotein (AFP) and β-human chorionic gonadotropin (βhCG) determination in a series of 30 patients bearing intracranial germ cell tumors. At diagnosis five patients had high serum and CSF AFP levels. No patient had positive serum AFP and negative CSF AFP or vice versa. Twelve of 30 patients had serum βhCG levels above 5 mIU/mL, eight had high βhCG only in CSF, and ten were completely negative. During treatment and follow-up both markers were accurate indicators of the response to therapy, decreasing rapidly and ofte
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10

Jauniaux, E., K. H. Nicolaides, A.-M. Nagy, M. Brizot та S. Meuris. "Total amount of circulating human chorionic gonadotrophin α and β subunits in first trimester trisomies 21 and 18". Journal of Endocrinology 148, № 1 (1996): 27–31. http://dx.doi.org/10.1677/joe.0.1480027.

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Abstract The aim of this study was to evaluate the variations in the balance between total (free and combined) circulating α and β subunits of human chorionic gonadotrophin (hCG) in trisomy 21 and 18. Maternal serum samples were collected at 10 and 11 weeks of gestation from 22 singleton pregnancies with trisomy 21 (n=17) and trisomy 18 (n=5) and 66 chromosomally normal controls, matched for gestational age. The hCG and free α and β subunits circulating levels were measured using specific immunoradiometric assays and converted in a common unit system obtained using calibration of the assays wi
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11

Nagy, A.-M., E. Jauniaux, D. Jurkovic та S. Meuris. "Placental production of human chorionic gonadotrophin α and β subunits in early pregnancy as evidenced in fluid from the exocoelomic cavity". Journal of Endocrinology 142, № 3 (1994): 511–16. http://dx.doi.org/10.1677/joe.0.1420511.

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Abstract Levels of human chorionic gonadotrophin (hCG) and of its free α and β subunits were measured using specific immunoradiometric assays in exocoelomic fluid (ECF) and maternal serum (MS) collected from five pregnant women at 6·6-8 weeks of gestation. Mean levels of hCG and its free subunits were significantly (P<0·001) higher in ECF than in MS: 3·5-fold for hCG, 600-fold for free αhCG and 38-fold for βhCG. There was no correlation between either hCG levels or levels of its free subunits in ECF and MS. On a molar basis, the quantity of free αhCG subunit expressed as a percentage of the
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12

Lobo Antunes, Isabel, Joana Curado, Ana Quintas та Alcides Pereira. "Negative βhCG and Molar Pregnancy: The Hook Effect". Acta Médica Portuguesa 30, № 9 (2017): 656. http://dx.doi.org/10.20344/amp.8603.

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Molar pregnancy, included in gestational trophoblastic disease, is a benign pathology with ability to metastasize, usually occurring with excessively high βhCG levels. Clinical scenario is usually a woman in extremes of reproductive age presenting with amenorrhoea, pain and vaginal blood loss; signs derived from high βhCG levels may be present (hyperthyroidism, hyperemesis). Diagnosis is based on a positive pregnancy test – usually a qualitative urinary test. The limitation of this test results from its inability to become positive in presence of markedly high levels of βhCG, saturating the an
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13

Ergül, Zeliha Nur, and Rahmi Sinan Karadeniz. "Organ-Preserving Methotrexate Treatment in Recurrent Ectopic Pregnancy: A Case Report." Türk Kadın Sağlığı ve Neonatoloji Dergisi 6, no. 2 (2024): 73–76. http://dx.doi.org/10.46969/ezh.1472903.

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Objective: To assess the significance of diagnosis, treatment, and management approaches in cases of recurrent ectopic pregnancies. Material and Method: This study presents the management of a 31-year-old woman with a history of left tubal pregnancy and subsequent left salpingectomy, who presented with a right tubal ectopic pregnancy. Methotrexate (MTX) treatment was initiated due to the absence of contraindications. On the first day of MTX, the patient’s serum βhCG level was 5135.64 U/L, but it continued to rise. Subsequently, the patient received a second dose of MTX. On the fourth day of th
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14

Nguyễn, Thị Kim Anh, та Xuân Phúc Võ. "Gia tăng nồng độ βhCG 48 giờ trước điều trị: yếu tố mới dự đoán kết quả điều trị nội khoa thai lạc chỗ bằng Methotrexate". Tạp chí Phụ sản 22, № 1 (2024): 70–74. http://dx.doi.org/10.46755/vjog.2024.1.1674.

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Mục tiêu nghiên cứu: Nghiên cứu sự biến thiên nồng độ βhCG trước, trong điều trị liên quan đến kết quả điều trị nội khoa Thai lạc chỗ bằng Methotrexate. Đối tượng và phương pháp nghiên cứu: Mô tả cắt ngang có theo dõi 41 bệnh nhân được chẩn đoán thai lạc chỗ và điều trị nội khoa bằng Methotrexate liều đôi tại Bệnh viện Trường Đại học Y - Dược Huế từ tháng 1/2020 đến 6/2022. Kết quả: Tỷ lệ thành công chung là 85,4%; Nồng độ βhCG trung bình ban đầu tại thời điểm điều trị là 1.814 ± 1.377,3 mUI/ml; Tỷ lệ gia tăng nồng độ βhCG trước điều trị ≤ 20,8% trong 48 giờ trước điều trị liều thứ nhất có giá
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15

Malik, Sara, Sobia Nawaz, Masooda Rasheed, Iqra Nadeem, Sajid Ali Shah та Falak Nigar. "Correlation of βhCG Levels with Size of Gestational Sac in Patients of Ectopic Pregnancy Presenting to a Tertiary Care Health Facility". National Journal of Health Sciences 7, № 4 (2022): 169–73. http://dx.doi.org/10.21089/njhs.74.0169.

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Abstract:The objective of this study was to determine correlation of β- HCG levels with size of gestational sac in patients of ectopic pregnancy presenting to a tertiary care health facility. Materials and Methods: This descriptive cross-sectional study was carried out in the Department of Obstetrics and Gynecology, district headquarter Hospital, Rawalpindi from Jan 2019 to Jan 2020. This study involved 100 pregnant women aged between 20-40 years diagnosed of ectopic pregnancy on transvaginal ultrasound. Serum βhCG level was acquired in all these women while the size of gestational sac was mea
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16

Smyth, Lisa Geraldine, Niall F. Davis, James C. Forde, Olive O’Kelly, Rrajnish K. Gupta, and Hugh Flood. "Metastatic seminoma presenting as flank pain." Canadian Urological Association Journal 7, no. 11-12 (2013): 826. http://dx.doi.org/10.5489/cuaj.1208.

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Seminoma is the most common single histological sub-type of testicular carcinoma. Patients usually present with a painless lump and stage I disease. We describe a case of an incidental metastatic seminoma in a 28-year-old man post-renal trauma with a dramatically elevated β-human chorionic gonadotropin (βHCG). His βHCG level has returned to normal post-orchidectomy and chemotherapy.
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17

Gandhi, Sejal, Neal Patel, Kunal Patel та Lisa Patel. "A βhCG Secreting Pancreatic Tumor". American Journal of Gastroenterology 107 (жовтень 2012): S334. http://dx.doi.org/10.14309/00000434-201210001-00811.

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18

Madu, A. E., та S. Canty. "Negative βHCG tubal ectopic pregnancy". Journal of Obstetrics and Gynaecology 26, № 2 (2006): 181–82. http://dx.doi.org/10.1080/01443610500475768.

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19

Beck, Stephen D. W., Richard S. Foster, Richard Bihrle, Lawrence H. Einhorn, and John P. Donohue. "Outcome Analysis for Patients With Elevated Serum Tumor Markers at Postchemotherapy Retroperitoneal Lymph Node Dissection." Journal of Clinical Oncology 23, no. 25 (2005): 6149–56. http://dx.doi.org/10.1200/jco.2005.11.684.

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Purpose To evaluate the therapeutic benefit of postchemotherapy retroperitoneal lymph node dissection (PCRPLND) in patients with persistently elevated serum tumor markers. Patients and Methods One hundred fourteen patients with metastatic germ cell cancer with elevated serum tumor markers after first-line (50 patients) or second-line chemotherapy (64 patients) who underwent PCRPLND between 1977 and 2000 with a minimum follow-up of 2-years were included in this retrospective study. Results The 5-year overall survival was 53.9%. Sixty-one patients (53.5%) are alive with a medium follow-up of 72
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20

Forstner, Désirée, Sabine Maninger, Olivia Nonn, et al. "Platelet-derived factors impair placental chorionic gonadotropin beta-subunit synthesis." Journal of Molecular Medicine 98, no. 2 (2019): 193–207. http://dx.doi.org/10.1007/s00109-019-01866-x.

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Abstract During histiotrophic nutrition of the embryo, maternal platelets may be the first circulating maternal cells that find their way into the placental intervillous space through narrow intertrophoblastic gaps within the plugs of spiral arteries. Activation of platelets at the maternal-fetal interface can influence trophoblast behavior and has been implicated in serious pregnancy pathologies. Here, we show that platelet-derived factors impaired expression and secretion of the human chorionic gonadotropin beta-subunit (βhCG) in human first trimester placental explants and the trophoblast c
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21

Özet, A., A. Arpaci, S. Kömiircü, and G. Üçkaya. "Human Chorionic Gonadotropin and CA 15-3 Producing Adenocarcinoma." Nuklearmedizin 37, no. 08 (1998): 297–98. http://dx.doi.org/10.1055/s-0038-1632352.

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Summary50 years old man suffering from primary lung adenocarcinoma presented with high levels of both beta subunit human chorionic gonadotropin (βHCG) and cancer antigen 15-3 (CA 15-3) in the absence of elevated carcinoembrionic antigen (CEA), alfa fetoprotein (AFP) and carbohydrate antigen 19-9 (CA 19-9). Although βHCG or CA 15-3 high levels were reported in adenocarcinoma of lung, this is the first report of a patient with high levels of both markers.
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22

ALLEN, Stephanie, John DAVIES, Martyn C. DAVIES, et al. "The influence of epitope availability on atomic-force microscope studies of antigen–antibody interactions." Biochemical Journal 341, no. 1 (1999): 173–78. http://dx.doi.org/10.1042/bj3410173.

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The ability of the atomic-force microscope (AFM) to detect interaction forces between individual biological molecules has recently been demonstrated. In this study, force measurements have been obtained between AFM probes functionalized with the β-subunit of human chorionic gonadotrophin (βhCG) and surfaces functionalized with anti-βhCG antibody. A comparison of the obtained results with previous anti-ferritin antibody-binding data identifies differences when the antigen molecule expresses only a single epitope (βhCG), rather than multiple epitopes (ferritin), for the monoclonal antibodies emp
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23

Febres, Maria Carter, Carol S. Bruggers, Holly Zhou, Arie Perry, John Kestle, and Nicholas Whipple. "GCT-70. INTRACRANIAL GROWING TERATOMA SYNDROME IN CHILDREN." Neuro-Oncology 22, Supplement_3 (2020): iii342. http://dx.doi.org/10.1093/neuonc/noaa222.286.

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Abstract Germ cell tumors account for less than 5% of all intracranial malignancies in children. Intracranial growing teratoma syndrome (GTS) is a rare pathophysiologic process characterized by growth of mature teratoma elements of a non-germinomatous germ cell tumor (NGGCT) during or following treatment with chemotherapy, in addition to normalization of or declining AFP/βHCG of the cerebral spinal fluid (CSF)/serum. A 13-year-old male presented with headache, emesis, and diplopia. MRI of the brain/spine revealed a localized 3.1 x 3.1 x 3.2 cm pineal tumor. Biopsy confirmed NGGCT (germinoma, i
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24

Fénichel, Patrick, Cécile Rouzier, Catherine Butori та ін. "Extragestational βHCG Secretion Due to an Isolated Lung Epithelioid Trophoblastic Tumor: Microsatellite Genotyping of Tumoral Cells Confirmed Their Placental Origin and Oriented Specific Chemotherapy". Journal of Clinical Endocrinology & Metabolism 99, № 10 (2014): 3515–20. http://dx.doi.org/10.1210/jc.2014-1460.

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Abstract Context: Persistent secretion of β-human chorionic gonadotropin (βHCG) in the absence of an ongoing or recent pregnancy and without persistent uterine gestational disease is a rare but challenging situation that requires locating the extrauterine secreting tumor and distinguishing between extragestational choriocarcinoma and gestational trophoblastic neoplasms. Case Presentation: An unexplained, persistent extragestational βHCG secretion occurring in a 29-year-old, nonsmoking woman with abnormal uterine bleeding 4 years after a normal pregnancy and without persistent gestational disea
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25

Dao, Nguyen Hung, Van Vu Truong, Minh Thang Ngo, Van Khoa Tran та Thi Thanh Hien Pham. "Nghiên cứu giá trị của β-hCG huyết thanh và siêu âm đường âm đạo trong theo dõi chửa ngoài tử cung". Tạp chí Phụ sản 16, № 2 (2018): 69–73. http://dx.doi.org/10.46755/vjog.2018.2.510.

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Mục tiêu: Xác định giá trị của mức độ tăng βhCG 48 giờ và siêu âm đường âm đạo ở bệnh nhân theo dõi chửa ngoài tử cung.
 Đối tượng và phương pháp: mô tả, tiến cứu 160 bệnh nhân được nhập viện theo dõi chửa ngoài tử cung tại Khoa Phụ 1- Bệnh viện Phụ Sản Trung ương từ 9/2017 đến 01/2018, xử lý số liệu bằng chương trình SPSS 16.0. Tính giá trị trung bình, so sánh hai giá trị trung bình, độ nhậy, độ đặc hiệu và xây dựng đường cong ROC.
 Kết quả: 160 bệnh nhân theo dõi chửa ngoài tử cung có 112 bệnh nhân chửa ngoài tử cung (CNTC), 21 bệnh nhân chửa trong tử cung (CTTC), 27 bệnh nhân sẩy
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Stabile, Guglielmo, Francesco Paolo Mangino, Federico Romano, Giulia Zinicola, and Giuseppe Ricci. "Ectopic Cervical Pregnancy: Treatment Route." Medicina 56, no. 6 (2020): 293. http://dx.doi.org/10.3390/medicina56060293.

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Background and objectives: Cervical pregnancy (CP) is a rare form of ectopic pregnancy (EP) in which the embryo implants and grows inside the endocervical canal. Early diagnosis is essential in order to allow conservative medical and surgical treatments. Although many treatment approaches are disponible, the most effective is still unclear. The aim of this study is to evaluate the efficacy of hysteroscopic management in early CP in order to preserve future fertility. Materials and Methods: This is a retrospective observational case series. Five patients with a diagnosis of CP, hemodynamically
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Rajecki, Maria, Lotta Kangasniemi, Mikko Tenhunen та ін. "950. βhCG Expressing CRAd for Prostate Cancer". Molecular Therapy 13 (2006): S366—S367. http://dx.doi.org/10.1016/j.ymthe.2006.08.1042.

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28

Ooi, D. S., та S. L. Perkins. "Serial serum βhCG levels in early pregnancy". Clinical Biochemistry 20, № 4 (1987): 293–94. http://dx.doi.org/10.1016/s0009-9120(87)80047-4.

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29

Aničić, Radomir, Aleksandar Rakić, Rastko Maglić, et al. "A Rare Case of Epithelioid Trophoblastic Tumor Presenting as Hematoma of a Caesarean Scar in the Lower Uterine Segment." Medicina 58, no. 1 (2021): 34. http://dx.doi.org/10.3390/medicina58010034.

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Epitheliod trophoblastic tumor (ETT) account for only 1–2% of all the cases of gestational trophoblastic neoplasia (GTN), with a reported mortality rate of 10–24%. ETT is derived from chorionic type intermediate trophoblastic cells, which appears to be the reason for the only slightly elevated βhCG levels in these patients. We present a case of a 42-year-old patient who was admitted to the clinic eight months after Caesarean delivery, for irregular vaginal bleed with normal values of beta-human chorionic gonadotropin (βhCG). A 6 × 5 cm hematoma was evacuated from the isthmic uterine segment du
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Ravelojaona, Marion, Julie Girouard, Emmanuelle Stella Kana Tsapi та ін. "Oncostatin M and STAT3 Signaling Pathways Support Human Trophoblast Differentiation by Inhibiting Inflammatory Stress in Response to IFNγ and GM-CSF". Cells 13, № 3 (2024): 229. http://dx.doi.org/10.3390/cells13030229.

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Interleukin-6 (IL-6) superfamily cytokines play critical roles during human pregnancy by promoting trophoblast differentiation, invasion, and endocrine function, and maintaining embryo immunotolerance and protection. In contrast, the unbalanced activity of pro-inflammatory factors such as interferon gamma (IFNγ) and granulocyte–macrophage colony-stimulating factor (GM-CSF) at the maternal–fetal interface have detrimental effects on trophoblast function and differentiation. This study demonstrates how the IL-6 cytokine family member oncostatin M (OSM) and STAT3 activation regulate trophoblast f
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Blomberg, Kaj, Pertti Hurskainen та Ilkka Hemmilä. "Terbium and Rhodamine as Labels in a Homogeneous Time-resolved Fluorometric Energy Transfer Assay of the β Subunit of Human Chorionic Gonadotropin in Serum". Clinical Chemistry 45, № 6 (1999): 855–61. http://dx.doi.org/10.1093/clinchem/45.6.855.

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Abstract Background: Fluorescence resonance energy transfer (FRET) is a powerful tool in analytical chemistry. The aim of the present work was to use FRET to design a homogeneous immunoassay. Methods: We used a highly fluorescent terbium (Tb3+) chelate (donor) and the organic fluorochrome rhodamine (acceptor) combined with time-resolved detection of the acceptor emission in homogeneous assay format for the measurement of the β subunit of human chorionic gonadotropin (βhCG) in serum. We used two antibodies labeled with Tb3+ and rhodamine, respectively, recognizing different epitopes on βhCG. Th
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Kaabia, O., R. Bouchahda, A. Skander, A. Ben Smida та M. Bibi. "EP41.07: Ectopic pregnancy with negative serum βHCG result". Ultrasound in Obstetrics & Gynecology 60, S1 (2022): 277. http://dx.doi.org/10.1002/uog.25869.

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Guichard, Raphael, та Jose Prieto. "787: Relationship between maternal serum βhCG and preeclampsia". American Journal of Obstetrics and Gynecology 204, № 1 (2011): S308—S309. http://dx.doi.org/10.1016/j.ajog.2010.10.809.

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Nagy, A.-M., D. Glinoer, G. Picelli та ін. "Total amounts of circulating human chorionic gonadotrophin α and β subunits can be assessed throughout human pregnancy using immunoradiometric assays calibrated with the unaltered and thermally dissociated heterodimer". Journal of Endocrinology 140, № 3 (1994): 513–20. http://dx.doi.org/10.1677/joe.0.1400513.

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Abstract The aim of the present study was to determine the variations in the balance between total (free plus combined) circulating α and β subunits of human chorionic gonadotrophin (hCG) throughout human pregnancy. The equivalence between the International Units (IU) of hCG (IRP 75/537) and those assigned to the α (IRP 75/569) and β (IRP 75/551) free subunits was experimentally determined by using intact and thermally dissociated hCG. Heat exposure (2 min at 100 °C) of hCG preparations resulted in a complete dissociation of hCG into free, soluble and intact α and β subunits. The hCG and α and
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Antony, Varghese, Anjali K. Pahuja, Jaskaran S. Sethi, and Tamilarasu Suresh. "Bifocal intracranial germ cell tumor: A diagnostic and therapeutic dilemma for radiation oncologists." Journal of Cancer Research and Therapeutics 20, no. 5 (2023): 1636–39. http://dx.doi.org/10.4103/jcrt.jcrt_1952_22.

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ABSTRACT An eight-year-old child presenting with increased thirst, raised intracranial tension and visual deterioration was diagnosed with synchronous suprasellar and pineal lesions, for which she underwent partial resection of the suprasellar lesion. Histopathological examination suggested pure germinoma. Tumor marker evaluation showed significantly raised levels of beta human chorionic gonadotropin (βHCG), favoring a non-germinoma germ cell tumor (NGGCT), leading to a diagnostic dilemma as the histology and βHCG levels were contradictory. Giving cognizance to the tumor marker levels, the tre
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Webb, A., P. Scott-Mackie, D. Cunningham та ін. "The prognostic value of CEA, βHCG, AFP, CA125, CA19-9 and C-erb B-2, (βHCG immunohistochemistry in advanced colorectal cancer". Annals of Oncology 6, № 6 (1995): 581–87. http://dx.doi.org/10.1093/oxfordjournals.annonc.a059248.

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Atkinson, Monique, Sarika Gupta та Therese Mcgee. "βhCG monitoring after single-dose methotrexate treatment of tubal ectopic pregnancy: Is the Day 4 βhCG necessary? A retrospective cohort study". Australian and New Zealand Journal of Obstetrics and Gynaecology 54, № 5 (2014): 475–79. http://dx.doi.org/10.1111/ajo.12257.

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Pazouki, Abdolreza, Somayeh Mokhber, Seyed Mohammad Tabatabaee Jabali, Fatemeh Sadat Hoseini Baharanchi, and Fetemeh Saffari. "A Case Series of Neglected Pregnancies at the Time of Bariatric Surgery." Annals of Bariatric Surgery 10, no. 1 (2021): 45–52. http://dx.doi.org/10.32598/abs.10.1.4.

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The aim of this study was to describe three neglected pregnancy at the time of bariatric surgery (BS) who had negative pregnancy test before surgery and underwent single-anastomosis gastric bypass surgery in obesity clinic in Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran. The first case was a 38 years old woman with BMI of 47.1 suffering from nausea and vomiting one month after surgery that medical treatment did not work and it was found positive βHCG test as and 13W + 6D fetus in sonography. The second case was a 30 years old woman with BMI of 46.2 suffering uteru
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Nguyễn, Thị Kim Anh, та Thị Linh Giang Trương. "Nghiên cứu đặc điểm cận lâm sàng và kết quả điều trị dọa sẩy thai tại Khoa Phụ sản Bệnh viện Trường Đại học Y - Dược Huế". Tạp chí Phụ sản 21, № 3 (2023): 43–49. http://dx.doi.org/10.46755/vjog.2023.3.1613.

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Mục tiêu: Nghiên cứu đặc điểm cận lâm sàng và kết quả điều trị các trường hợp dọa sẩy thai tại Khoa Phụ sản, Bệnh viện Trường Đại học Y - Dược Huế.
 Đối tượng và phương pháp nghiên cứu: 82 thai phụ được chẩn đoán là dọa sẩy thai được nằm điều trị tại Khoa Phụ sản, Bệnh viện Trường Đại học Y - Dược Huế từ tháng 06/2022 đến tháng 02/2023, thực hiện theo phương pháp mô tả cắt ngang.
 Kết quả: Dọa sẩy thai gặp nhiều nhất ở nhóm tuổi mẹ từ 25 - 29 tuổi chiếm tỷ lệ 39,0%. Giá trị trung bình βhCG tăng dần và cao nhất ở tuần thai 7 tuần - < 13 tuần, sau đó giảm dần ở các tuần thai tiếp th
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Brun, Miranda M., Laura Holloway, Amanda Oleksy та ін. "Analytical evaluation of the Radiometer AQT90 FLEX βhCG assay". Practical Laboratory Medicine 14 (березень 2019): e00116. http://dx.doi.org/10.1016/j.plabm.2019.e00116.

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41

Graulet, AM. "Informations Réactifs : T3 libre et sous-unité βhCG libre". Immuno-analyse & Biologie Spécialisée 15, № 3 (2000): 194–202. http://dx.doi.org/10.1016/s0923-2532(00)80009-5.

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Dev, Kapil, Anoop Sharma та Rajeev Sood. "Assessment of maternal serum β hCG level in pregnancy induced hypertension and normotensive patients and to correlate between the level of β hCG with the severity of pre-eclampsia and eclampsia". International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, № 11 (2019): 4314. http://dx.doi.org/10.18203/2320-1770.ijrcog20194849.

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Background: Hypertensive disorders during pregnancy are one of the most common medical complication seen during pregnancy, affecting around 5-10% of all pregnancies. Spectrum of this disease ranges from mildly elevated blood pressure with minimal clinical significance to severe hypertension with multi organ dysfunction. Pre-eclampsia complicates about 2-8% of all pregnancies. Pre-eclampsia incidence in India is about 8-10%. Various studies have depicted that, there is a strict relationship between PIH and elevated serum β-hCG level.Methods: This one-year prospective case control study toteled
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Hidayat, Yudi Mulyana, Supriadi Gandamihardja та Sofie Rifayani Krisnadi. "Hubungan Kadar βHCG Praevakuasi, Gambaran Histopatologi, dan Kista Lutein dengan Performa βHCG pada Penderita Mola Hidatidosa yang Berkembang Menjadi PTG dan Kembali Normal". Majalah Kedokteran Bandung 46, № 4 (2014): 247–52. http://dx.doi.org/10.15395/mkb.v46n4.345.

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Bobdiwala, S., B. De Cock, R. Harvey та ін. "OP18.07: The potential use of urinary βhCG for managing pregnancies of unknown location (PUL): correlating urinary and serum βhCG levels using two immunoassays". Ultrasound in Obstetrics & Gynecology 48, S1 (2016): 110. http://dx.doi.org/10.1002/uog.16332.

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45

Mai, Trong Dung, та Huy Hien Hao Pham. "Khảo sát giá trị của beta hCG tự do và hCG toàn phần huyết thanh trong bệnh lý chửa trứng". Tạp chí Phụ sản 16, № 3 (2019): 62–67. http://dx.doi.org/10.46755/vjog.2019.3.1074.

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Mục tiêu: (1) Khảo sát giá trị của beta hCG tự do và hCG toàn phần trong bệnh chửa trứng. (2) Xác định mối tương quan giữa beta hCG tự do và hCG toàn phần trong bệnh lý chửa trứng. Phương pháp nghiên cứu: Mô tả cắt ngang, theo dõi dọc. Đối tượng nghiên cứu: 90 trường hợp chửa trứng được điều trị tại Bệnh viện Phụ Sản Trung ương. Kết quả nghiên cứu: Tỷ lệ biến chứng u nguyên bào nuôi của chửa trứng là 20%. Giá trị của βhCG tự do huyết thanh của người bệnh chửa trứng trước khi thực hiện thủ thuật hoặc phẫu thuật là 435+457 IU/L, giá tự của hCG toàn phần huyết thanh là 163.680± 148.997 IU/L và có
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46

Pretorius, Carel J., Stephen du Toit, Urs Wilgen, et al. "How comparable are total human chorionic gonadotropin (hCGt) tumour markers assays?" Clinical Chemistry and Laboratory Medicine (CCLM) 58, no. 3 (2020): 438–44. http://dx.doi.org/10.1515/cclm-2019-0457.

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AbstractBackgroundTotal human chorionic gonadotropin (hCGt) tumour marker testing is regarded as an “off label” application for most commercial methods. We compared four assays in patients with a hCGt tumour marker request. We hypothesised that regression slopes would be altered and that outliers would be more common with tumour marker than with pregnancy samples if the detection of malignancy associated hCG molecular forms differed amongst assays. Further such systematic differences would be obvious and large enough to change clinical management decisions.ResultsWe measured hCGt in 390 sample
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So, Melody, Katherine Koniares, Wesley Nilsson, David Schmidt, and Danielle Luciano. "Chronic ectopic pregnancy after intrauterine insemination: A case report and review of the literature." Journal of Case Reports and Images in Obstetrics and Gynecology 11, no. 1 (2025): 77–82. https://doi.org/10.5348/100204z08ms2025cr.

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Introduction: Chronic ectopic pregnancy is a rare form of ectopic pregnancy characterized by repeated tubal injury and bleeding, leading to development of a chronic, inflammatory pelvic mass. Patients often present with mild, nonspecific symptoms, and a low beta-human chorionic gonadotropin (βhCG) level. Despite the established association between assisted reproductive technology and increased risk of ectopic pregnancy, this is the first reported case of a chronic ectopic pregnancy following intrauterine insemination. Case Report: A 27-year-old primigravid female with primary infertility in th
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48

Lee-A-Ping, Kathrine, та Jimmy Li Voon Chong. "A case of gynecomastia from a βhCG secreting bladder tumour". Journal of Clinical and Translational Endocrinology: Case Reports 13 (вересень 2019): 100052. http://dx.doi.org/10.1016/j.jecr.2019.100052.

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49

Vela, G., M. Luna, E. D. Flisser, F. Arredondo, B. Sandler та A. B. Copperman. "Defining early βhCG dynamics in IVF-conceived monozygotic (MZ) pregnancies". Fertility and Sterility 94, № 4 (2010): S24—S25. http://dx.doi.org/10.1016/j.fertnstert.2010.07.093.

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50

Đặng, Văn Tân, Sĩ Phúc An Lê, Tuyết Trinh Nguyễn, Minh Thắng Trần, Khắc Tú Châu та Sĩ Phương Lê. "Hiệu quả kỹ thuật “khâu thắt miệng túi” trong phẫu thuật nội soi thai làm tổ đoạn kẽ". Tạp chí Phụ sản 18, № 4 (2021): 58–64. http://dx.doi.org/10.46755/vjog.2020.4.1148.

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Mục tiêu: Đánh giá hiệu quả kỹ thuật hỗ trợ “khâu thắt miệng túi” trong phẫu thuật nội soi điều trị thai làm tổ ở đoạn kẽ.
 Phương pháp nghiên cứu: nghiên cứu loạt ca trên các bệnh nhân thai làm tổ đoạn kẽ và được điều trị phẫu thuật nội soi bằng kỹ thuật hỗ trợ “khâu thắt miệng túi” trước khi xẻ hoặc cắt góc tử cung tại khoa Phụ Sản Bệnh viện Trung Ương Huế từ tháng 1/2019 đến 8/2020.
 Kết quả: tổng cộng có 14 bệnh nhân được thu nhận. Độ tuổi trung bình là 31,1 4,5 tuổi (từ 27 - 43 tuổi). Tuổi thai trung bình theo kinh cuối cùng 7,5 1,8 tuần (từ 5 - 12 tuần), 7 trường hợp (50%) khôn
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