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1

Ахмедова, Саодат Ташболтаевна, Зухриддин Алишерович Абдурахманов, Яхё Равшанович Абдукаримов та Шахзода Зокиржоновна Искадарова. "Рабдовирусы (бешенство): распространённость, лечение и профилактика". Multidisciplinary Journal of Science and Technology 5, № 5 (2025): 1426–28. https://doi.org/10.5281/zenodo.15549642.

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 Рабдовирусы (бешенство): распространённость, лечение и профилактика. Рабдовирусы представляют собой семейство вирусов, к которому относится возбудитель бешенства — вирус Rabies. Бешенство остаётся одной из самых опасных зоонозных инфекций, характеризующейся почти 100% летальностью при развитии клинической стадии заболевания. Вирус бешенства широко распространён по всему миру, особенно в странах Азии и Африки, где отсутствует эффективный ветеринарный и санитарный контроль. Основной путь передачи вируса — через укусы инфицированных животных, преимущественно диких и домашних мле
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2

Есембекова, Г. Н., А. О. Амиргазин, А. Б. Шевцов, А. Ж. Абенова, А. М. Кабжанова та С. К. Абдрахманов. "ПРОТОКОЛ ПОЛНОГЕНОМНОГО СЕКВЕНИРОВАНИЯ И ГЕНОТИПИРОВАНИЯ ИЗОЛЯТОВ RABIES VIRUS". HERALD OF SCIENCE OF S SEIFULLIN KAZAKH AGRO TECHNICAL UNIVERSITY, № 4 (115) (21 грудня 2022): 4–15. http://dx.doi.org/10.51452/kazatu.2022.4.1194.

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Цель данной работы - описание протокола полногеномного секвенирования клинических образцов РНК Rabies lyssavirus на платформе Illumina MiSeq. Ранее, генотипирование вируса бешенства, циркулирующего на территории Казахстана, проводилось на основе последовательности гена нуклеопротеина (N ген). В данной работе описывается способ секвенирования и генотипирования полногеномных последовательностей местных изолятов вируса бешенства. В протоколе описываются методы пробоподготовки, секвенирования и генотипирования применяемые в настоящее время для эпидемиологического анализа не только Rabies lyssaviru
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3

Ahunova, Alsu R., Rafail M. Akhmadeev, Gusaliya S. Arutyunyan, Zamilya Z. Aleeva, and Gelfirya M. Yarullina. "Recombinant rabies virus glycoprotein (rRVG) for serological diagnosis." Veterinariya, Zootekhniya i Biotekhnologiya 10, no. 131 (2024): 71–76. https://doi.org/10.36871/vet.zoo.bio.202410009.

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This paper presents the results of developing a method for obtaining a recombinant rabies virus glycoprotein (RVG) for serological diagnostics. We performed a bioinformatics analysis of the genomes of rabies virus strains and epizootic isolates, determined the main immunogenic epitopes and other structures that affect the choice of glycoengineering strategy for protein expression. Recombinant DNA was constructed based on fragments of the rabies virus G gene. Based on the expression strain E. coli BL21(DE3), a producer strain was obtained that allows expressing a mature recombinant product with
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4

Agoltsov, Valery Aleksandrovich, Oksana Petrovna Biryukova, Larisa Pavlovna Padilo, and Artur Andreevich Gusev. "ANALYSIS OF THE IMPACT OF NATURAL FACTORS ON THE CIRCULATION OF RABIES VIRUS AMONG RESERVOIR HOSTS." SCIENTIFIC LIFE 17, no. 2 (2022): 303–14. http://dx.doi.org/10.35679/1991-9476-2022-17-2-303-314.

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Wildlife is a reservoir for many pathogens, including the rabies virus. While carnivores (Carnivora) and bats (Chiroptera) are the main orders of mammals acting as natural reservoirs of rabies virus (RABV), the role of most other orders of mammals remains less well known. As a result of the evolution of the pathogen, climatic, landscape changes, anthropogenic impact on wildlife, the characteristics of the main hosts of the rabies virus change, new reservoirs of the virus appear. It has been established that environmental factors affect the circulation of the rabies virus among reservoir hosts
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5

Nesterchuk, S. L., E. A. Makarova, and V. A. Ostapenko. "The importance of individual animal species in rabies virus transport in the Central federal district." Veterinariya, Zootekhniya i Biotekhnologiya 1, no. 4 (2020): 15–21. http://dx.doi.org/10.36871/vet.zoo.bio.202004002.

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The Rabies – a viral disease characterized by severe damage of the nervous system. The analysis of data from the Rospotrebnadzor for 4 years (from 2015 to 2018) on the varmint of animals with rabies in four regions of the Central Federal District with different population densities is carried out. The main carriers of rabies virus in the region are the red fox, raccoon dog, stray dogs and cats; the role of other species is not so significant and rarely exceeds 1% of the total number of animals with suspected rabies. It has been established that in areas with a low population (Tver region) the
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6

Kalabekov, Mutalif Ibragimovich, and Milana Sergeevna Ordasheva. "DETERMINATION OF THE EFFECTIVENESS OF THE RT–PCR METHOD IN THE DIAGNOSIS OF RABIES VIRUS: ITS NECESSITY AND JUSTIFICATION." SCIENTIFIC LIFE 19, no. 3 (2024): 502–7. http://dx.doi.org/10.35679/1991-9476-2024-19-3-502-507.

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The rabies virus remains one of the most dangerous infectious diseases that can affect mammals, including humans. Rapid and accurate diagnosis of this virus is critical for taking measures to control its spread and prevent possible epidemics. In recent years, RT-PCR (reverse transcriptase polymerase chain reaction) has become an increasingly popular tool in the molecular diagnosis of various infections, including the rabies virus. The use of the RT-PCR method in diagnosing the rabies virus is not only necessary, but also justified. Its high efficiency, speed and relative ease of use, as well a
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7

Krykbayev, Yerkin, Anara Nurmukhambetova, Elmira Bitanova, and Gulbaram Ustenova. "BIOREACTOR TECHNOLOGY OF SUSPENSION CULTIVATION OF THE RABIES VIRUS CVS-11." 3i intellect idea innovation - интеллект идея инновация 1 (2025): 52–58. https://doi.org/10.52269//22266070_2025_1_52.

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The development of bioreactor technologies of suspension cultivation is a promising tool for producing large quantities of cells for subsequent virus infection. Traditional static cultivation methods using flasks are widely employed but present several significant drawbacks. These include high risks of fungal and bacterial contamination, low virus yield against large cultivation area requirements, and complex technological workflows. Modern bioreactor cultivation technologies address these limitations while offering substantial advantages, including automated control of key parameters such as
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8

Sansyzbay, Abylay, Yerkin Krykbayev, Dauren Mukhanov, and Maksat Berdikulov. "ANALYSIS OF THE EFFICIENCY OF PRESERVING THE VIABILITY OF THE RABIES VIRUS USING A TRANSPORT MEDIUM." 3i intellect idea innovation - интеллект идея инновация 1 (2025): 72–79. https://doi.org/10.52269//22266070_2025_1_72.

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The article is devoted to the study of the efficiency of preserving the viability of the rabies virus using a specialized transport medium. Rabies is a dangerous zoonotic disease, and maintaining the stability of the virus during transportation is critical for diagnostics, vaccine development, and scientific research. The aim of the work was to assess the effect of the composition of the transport medium on the stability of viral particles and their ability to replicate after transportation. The results of the study showed that the use of a specialized transport medium significantly increases
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9

Л.К., Сарыглар. "РАСПРОСТРАНЕНИЕ БЕШЕНСТВА ЖИВОТНЫХ В РЕСПУБЛИКЕ ТЫВА". Bulletin of KSAU, № 02 (18 лютого 2020): 93–97. http://dx.doi.org/10.36718/1819-4036-2020-2-93-97.

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Представлены данные распространения бешенства на территории Республики Тыва среди животных разных видов: сельскохозяйственных, домашних и диких. Проанализированы случаи заболеваемости бешенства среди животных на территории республики с 1979 по 2019 год по данным годовых отчетов Республиканской ветеринарной лаборатории, Республиканского управления ветеринарии, Омского научно-исследовательского института природно-очаговых инфекций Роспотребнадзора. Изучены региональные особенности проявления бешенства среди животных за определенные периоды по географическому положению региона, экологическим особ
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10

Shishkov, A. V., A. A. Pyatkina, and B. L. Manin. "ADAPTATION DYNAMICS OF THE RABIES VIRUS OF "RV-97" VACCINE STRAIN TO MONOLAYER VNK-21/13 CELL CULTURE." Vestnik of Ulyanovsk state agricultural academy 250 (June 25, 2021): 157–64. http://dx.doi.org/10.18286/1816-4501-2021-2-157-164.

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The problem of rabies as one of the most dangerous zoonoses continues to be relevant almost all over the world. In development of a live vaccine, an important stage is to obtain an active component - a virus that retains the given phenotypic properties, pathogen cultivation system plays the main role. The aim of this work was to adapt the rabies virus of “RV-97” strain to the finite cell line of the Syrian hamster kidney (VNK -21/13) of the Swedish subline, as well as to carry out a comparative analysis of virus accumulation at different passages. The number of passages that need to be carried
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11

Shishkov, A. V., A. A. Pyatkina, and B. L. Manin. "ADAPTATION DYNAMICS OF THE RABIES VIRUS OF "RV-97" VACCINE STRAIN TO MONOLAYER VNK-21/13 CELL CULTURE." Vestnik of Ulyanovsk state agricultural academy 250 (June 25, 2021): 157–64. http://dx.doi.org/10.18286/1816-4501-2021-2-157-164.

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The problem of rabies as one of the most dangerous zoonoses continues to be relevant almost all over the world. In development of a live vaccine, an important stage is to obtain an active component - a virus that retains the given phenotypic properties, pathogen cultivation system plays the main role. The aim of this work was to adapt the rabies virus of “RV-97” strain to the finite cell line of the Syrian hamster kidney (VNK -21/13) of the Swedish subline, as well as to carry out a comparative analysis of virus accumulation at different passages. The number of passages that need to be carried
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12

Zaykova, O. N., M. A. Losich, O. A. Verkhovsky, et al. "A comparative molecular-genetic analysis of rabies virus in Russian Federation: rabies in cats." "Veterinary Medicine" Journal 23, no. 03 (2020): 21–28. http://dx.doi.org/10.30896/0042-4846.2020.23.3.21-28.

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13

Shishkov, A. V., V. Yu Kulakov, and D. A. Lozovoy. "REPRODUCTION OF THE RABIES VIRUS OF “RV-97” STRAIN IN THE SUSPENSION CULTURE OF VNK-21 / SUSP / ARRIAH AND VNK -21 / 2-17 CELLS." Vestnik of Ulyanovsk state agricultural academy 230 (September 25, 2021): 156–63. http://dx.doi.org/10.18286/1816-4501-2021-3-156-163.

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The study of new suspension cell lines for rabies virus cultivation is a topical area of biotechnology. The article presents results of specification of sensitivity of BNK-21 / SUSP / ARRIAH subline to the rabies virus of “RV-97” strain. A comparison of two highly potential suspension cell cultures of VNK 21 for production of viral material with a high titer of infectious activity is shown [1]. The estimation of the titers of the rabies virus of “RV-97” strain (lg’T, CCID 50 / cm3) was carried out, the titers were established after 48 hours of cultivation in the suspension subline of VNK -21 c
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14

Varianytsia, Viktoriia V., and Igor P. Vysekantsev. "Freeze-Drying and Subsequent Storage of Fixed Pasteur Strain Rabies Virus." Problems of Cryobiology and Cryomedicine 27, no. 2 (2017): 162. http://dx.doi.org/10.15407/cryo27.02.162.

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15

Mukhamedzhanova, А. G., R. M. Akhmadeev, N. R. Miftakhov, et al. "Optimization of laboratory animals hyperimmunization schemes with a highly purified rabies virus antigen." "Veterinary Medicine" Journal 23, no. 10 (2020): 25–29. http://dx.doi.org/10.30896/0042-4846.2020.23.10.25-29.

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16

Galeeva, A. G., N. I. Khammadov, Z. Z. Aleeva, et al. "Nucleotide polymorphism of G-gene of fixed rabies virus strain «Sheep VGNKI»." "Veterinary Medicine" Journal 27, no. 02 (2024): 13–18. http://dx.doi.org/10.30896/0042-4846.2024.27.2.13-18.

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17

Иванов, О. В., Д. Ю. Костерин, and Л. Э. Мельникова. "THE ROLE OF A RACCOON DOG IN MAINTAINING EPIZOOTY OF RABIES IN THE YAROSLAVL REGION." Vestnik APK Verhnevolzh`ia, no. 2(58) (June 30, 2022): 86–90. http://dx.doi.org/10.35694/yarcx.2022.58.2.012.

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В Центральном федеральном округе Российской Федерации за последние двадцать пять лет сложилась напряжённая ситуация по бешенству животных. Сформировались крупные очаги стационарного неблагополучия по этой инфекции. Каждый регион имеет свои особенности по распространению, интенсивности, сезонности и количественным характеристикам этой болезни. Ситуация, сложившаяся в Ярославской области, требует повышенного внимания в силу многогранности течения эпизоотического процесса в этом регионе. Около двадцати лет здесь регулярно регистрируется бешенство животных, локомотивом которого является природная
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18

Mukhamedzhanova, A. G., M. A. Efimova, A. N. Chernov, K. S. Khaertynov, and R. M. Akhmadeev. "OBTAINING RABIES VIRUS ANTIGEN AND ASSESSMENT OF ITS ACTIVITY AND SPECIFICITY IN IMMUNOSORBENT ASSAY AND IMMUNOBLOT." SCIENTIFIC NOTES KAZAN BAUMAN STATE ACADEMY OF VETERINARY MEDICINE 236, no. 4 (2018): 138–42. http://dx.doi.org/10.31588/2413-4201-1883-236-4-138-142.

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19

D.V., Palii, Mohniy G.O., and Voinalovych O.O. "RABIES - AN INFECTIOUS DISEASE WITH A FATAL OUTCOME (CLINICAL CASE)." Наука и здравоохранение, no. 1(26) (February 28, 2024): 247–52. http://dx.doi.org/10.34689/sh.2024.26.1.029.

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Actuality. Rabies is an acute, progressive, incurable infectious disease accompanied by viral encephalitis. The main reservoirs of the virus in wild nature are two genera of mammals, but the greatest danger worldwide is rabid dogs. Today, rabies is registered in 150 countries and territories of the world, on all continents except Antarctica. Aim. To assess the current situation regarding rabies in Ukraine in general and in the Vinnytsia region in particular, we collected information on the current state of rabies cases and analyzed the medical record of a patient hospitalized with this disease
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20

V. Burkova, Viktoriya, and Olga V. Pishko. "Infectious activity of industrial strains of rabies virus after storage at –20, –80°C." Problems of Cryobiology and Cryomedicine 24, no. 2 (2014): 175. http://dx.doi.org/10.15407/cryo24.02.175.

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21

V. Burkova, Viktoriya, and Aleksey A Lavrik. "Activity of rabies virus strain CVS (20% cerebral suspension) after storage at different temperatures." Problems of Cryobiology and Cryomedicine 25, no. 2 (2015): 170. http://dx.doi.org/10.15407/cryo25.02.170.

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22

V. Burkova, Viktoria. "Storage of Rabies Virus Strains L. Pasteur and CVS at Low Temperatures Using Cryoprotectants." Problems of Cryobiology and Cryomedicine 26, no. 2 (2016): 162. http://dx.doi.org/10.15407/cryo26.02.162.

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23

Zelenina, Galina. "Torah against the Virus, Rabbis against the Government: Ultra-Orthodoxy Facing the Pandemic." State Religion and Church in Russia and Worldwide 39, no. 1 (2021): 101–22. http://dx.doi.org/10.22394/2073-7203-2021-39-1-101-122.

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The paper discusses a number of the most remarkable responses to the COVID‑19 pandemic and to the social isolation measures coming from several, mostly ultra‑Orthodox, Jewish communities in Israel, the United States, and Russia. It examines major elements of the crisis discourse, i.e., the hermeneutics of the causes and meanings of the pandemic; the affirmation of group borders and hierarchies as a result of the search for culprits; the relations between the religious community and the state; as well as the possible transformations of social behavior and ritual practices resulting from the cri
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24

Varianytsia, Viktoriia V., and Igor P. Vysekantsev. "Infectious Activity of L. Pasteur Rabies Virus Vaccine Strain Frozen-Dried in Various Protective Media and Then Stored at Various Temperatures." Problems of Cryobiology and Cryomedicine 28, no. 4 (2018): 333–42. http://dx.doi.org/10.15407/cryo28.04.333.

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25

Varianytsia, Viktoriia V., and Igor P. Vysekantsev. "Long-Term Storage of Rabies Virus Fixed Strains L. Pasteur and CVS at Temperatures of –20 and –80°C Using Protective Media." Problems of Cryobiology and Cryomedicine 28, no. 2 (2018): 169. http://dx.doi.org/10.15407/cryo28.02.169.

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26

Shmarov, M. M., E. S. Sedova, A. E. Nikonova, et al. "Immunogenic and protective properties of the recombinant human adenovirus serotype 5 expressing the glycoprotein G gene of the rabies virus vaccine strain RV-97." Immunologiya 41, no. 4 (2020): 312–25. http://dx.doi.org/10.33029/0206-4952-2020-41-4-312-325.

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27

Varianytsia, Viktoriia, and Igor Vysekantsev. "Storage of Standard Fixed Rabies Virus CVS Strain in Protective Media with Sucrose, Glycerol and Maltose at Diff erent Temperatures During One Year." Problems of Cryobiology and Cryomedicine 29, no. 2 (2019): 153. http://dx.doi.org/10.15407/cryo29.02.153.

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28

Осадчук, Михаил Александрович, Ирина Дмитриевна Лоранская та Максим Михайлович Осадчук. "ВАКЦИНАЦИЯ В ИСТОРИЧЕСКОМ АСПЕКТЕ". University therapeutic journal 6, № 3 (2024): 36–43. https://doi.org/10.56871/utj.2024.26.34.003.

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Вакцинация населения способна спасти от 2–3 до 6 млн человеческих жизней в год, избежать возникновения тяжелых заболеваний и повысить общую продолжительность жизни. История вакцинации началась за 1000 лет до наступления нашей эры. Именно к той эпохе относятся первые прививки от оспы с помощью вариоляции. Однако в Европе вариоляция с целью профилактики оспы стала применяться только с начала XVIII в. В XIX в. началась вакцинация от оспы. К концу XIX в. кроме вакцины от оспы в клиническую практику были внедрены вакцины от четырех заболеваний: бешенства — в 1885 г., брюшного тифа и холеры — в 1896
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Валентина Лазарева. "Бешенство". Журнал здорового питания и диетологии, № 15 (4 лютого 2021). http://dx.doi.org/10.59316/j.edpl.2021.15.51.

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Бешенство – заболевание инфекционного типа, которое возникает при попадании в рану вируса Rabies через укус больного животного. Болеть могут как животные, так и люди. В среднем, инкубационный период у людей длится от 7-9 дней до 45-50. Все зависит от того, где был укус (чем ближе к голове, тем быстрее начинают свое проявление симптомы).
 https://edaplus.info/feeding-in-sickness/rabies.html
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