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Journal articles on the topic '0.5% Bupivacaine'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Kishore, Hari, Rajagopal P, Binu Puthur Simon, and Karthika Asokan. "COMPARISON BETWEEN 0 . 5% BUPIVACAINE - DEXAMET HASONE COMBINATION & 0 . 5% BUPIVACAINE - CLONIDINE COMBINATION IN BRACHIAL PLEXUS BLOCKS BY SUPRACLAVICULAR APPROACH." Journal of Evidence Based Medicine and Healthcare 2, no. 20 (2015): 3016–24. http://dx.doi.org/10.18410/jebmh/2015/437.

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Hafiz Ahmad Jalal, Mudassar Murtaza, Noor Fatima, and Ayesha Khalid. "Comparison of intraperitoneal instillation of Bupivacaine vs Normal Saline for postoperative pain relief after laparoscopic cholecystectomy." Professional Medical Journal 31, no. 05 (2024): 682–88. http://dx.doi.org/10.29309/tpmj/2024.31.05.8022.

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Objective: To evaluate whether local irrigation of Bupivacaine reduces post-operative pain after cholecystectomy. Study Design: Prospective, Randomized Controlled Trial. Setting: Department of Surgery, Government Teaching Hospital, Shahdara Lahore. Period: June 2020 to December 2022. Methods: For this study, 86 participants were divided into two groups, each containing 43 participants (Bupivacaine vs. no Bupivacaine). The control group (Group A) received an infiltration of 15 ml of 0.5% bupivacaine in the sub-diaphragmatic region on the right side and at port sites, while normal saline was adm

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Azemati, Simin, Amir Zarghami, Reza Jouybar, and Vida Naderi-boldaji. "Analgesic Characteristics of Bupivacaine Alone and in Combination with Dexmedetomidine or Meperidine in Spinal Anesthesia during Cesarean Section: A Double-Blind Randomized Clinical Trial Study." Pain Research and Management 2022 (July 18, 2022): 1–7. http://dx.doi.org/10.1155/2022/5111214.

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Background. Comparing bupivacaine’s adjuvants in spinal anesthesia, we assessed the specific blocking characteristics and adverse effects of bupivacaine alone and in combination with dexmedetomidine or meperidine in spinal anesthesia during cesarean section. Methods. In this double-blind randomized clinical trial study, ninety pregnant women were divided into groups to receive 10 mg bupivacaine (group B), 10 mg bupivacaine with 5 μg dexmedetomidine (group BD), or 10 mg bupivacaine with 10 mg meperidine (group BM) intrathecal. Patients were assessed for the quality of analgesia during operation

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Patel, Kinjal M. "Liposomal Bupivacaine Versus Bupivacaine for Intercostal Nerve Blocks in Thoracic Surgery: A Retrospective Analysis." Pain Physician 3;23, no. 6;3 (2020): E251—E258. http://dx.doi.org/10.36076/ppj.2020/23/e251.

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Background: Liposomal bupivacaine (LipoB), delivered via intercostal nerve blocks (ICNBs), is increasingly being used for postoperative pain control in thoracic surgery patients, but there is limited data on its effectiveness when compared to standard bupivacaine. Objective: We sought to compare postoperative opioid use, pain control, and length of stay (LOS) in patients undergoing thoracic surgery with LipoB ICNBs vs patients undergoing thoracic surgery with ICNBs using standard bupivacaine. Study Design: A retrospective analysis. Setting: Research took place in a tertiary academic medical ce

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Sveticic, Gorazd, Andrea Gentilini, Urs Eichenberger, et al. "Combinations of Bupivacaine, Fentanyl, and Clonidine for Lumbar Epidural Postoperative Analgesia." Anesthesiology 101, no. 6 (2004): 1381–93. http://dx.doi.org/10.1097/00000542-200412000-00019.

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Background The authors developed and applied a method to optimize the combination of bupivacaine, fentanyl, and clonidine for continuous postoperative lumbar epidural analgesia. Methods One hundred eighteen patients undergoing knee or hip surgery participated in the study. Postoperative epidural analgesia during 48 h after surgery was optimized under restrictions dictated by side effects. Initially, eight combinations of bupivacaine, fentanyl, and clonidine (expressed as drug concentration in the solution administered) were empirically chosen and investigated. To determine subsequent combinati

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Maharjan, SK, and S. Shrestha. "Intraperitoneal magnesium sulphate plus bupivacaine for pain relief after laparoscopic cholecystectomy." Journal of Kathmandu Medical College 1, no. 1 (2012): 21–25. http://dx.doi.org/10.3126/jkmc.v1i1.7251.

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Background: Multimodal analgesia is necessary for management of pain after laparoscopic cholecystectomy. Magnesium sulphate is a new emerging drug for management of acute pain. This study was performed to study the analgesic efficacy of intraperitoneal bupivacaine and bupivacaine plus magnesium sulphate for postoperative pain relief after laparoscopic cholecystectomy. Methods: At the end of laparoscopic cholecystectomy, 60 patients were randomized to one of the following groups: bupivacaine group receiving intraperitoneal instillation of 30 ml of 0.25% bupivacaine and magnesium sulphate group

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Amundson, Adam W., Rebecca L. Johnson, Matthew P. Abdel, et al. "A Three-arm Randomized Clinical Trial Comparing Continuous Femoral Plus Single-injection Sciatic Peripheral Nerve Blocks versus Periarticular Injection with Ropivacaine or Liposomal Bupivacaine for Patients Undergoing Total Knee Arthroplasty." Anesthesiology 126, no. 6 (2017): 1139–50. http://dx.doi.org/10.1097/aln.0000000000001586.

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Abstract Background Multimodal analgesia is standard practice for total knee arthroplasty; however, the role of regional techniques in improved perioperative outcomes remains unknown. The authors hypothesized that peripheral nerve blockade would result in lower pain scores and opioid consumption than two competing periarticular injection solutions. Methods This three-arm, nonblinded trial randomized 165 adults undergoing unilateral primary total knee arthroplasty to receive (1) femoral catheter plus sciatic nerve blocks, (2) ropivacaine-based periarticular injection, or (3) liposomal bupivacai

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Shchegolkov, Ye E. "Comparative characteristics of the effectiveness of spinal anesthesia with intrathecal administration of bupivacaine and its combination with adjuvants." EMERGENCY MEDICINE 20, no. 1 (2024): 51–57. http://dx.doi.org/10.22141/2224-0586.20.1.2024.1658.

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Background. Currently, there is active discussion regarding the effectiveness of different adjuvants in spinal anesthesia. Objective: to compare the effectiveness of dexmedetomidine and fentanyl as adjuvants in combination with intrathecal bupivacaine administration during biportal endoscopic discectomy. Materials and methods. The study included 150 patients. Using block randomization based on a sample size, patients were divided intro the following groups: 1) group 1 — intrathecal hyperbaric bupivacaine 2.5 ml in 0.5 ml of normal saline; 2) group 2 — intrathecal hyperbaric bupivacaine 2.5 ml

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Altınsoy, Savaş, Ali Can, Gözde İnan, Mehmet Murat Sayın, and Onur Özlü. "Comparison of bupivacaine and levobupivacaine in continuous axillary brachial plexus block." Eurasian Journal of Anesthesiology and Intensive Care 1, no. 1 (2024): 11–15. http://dx.doi.org/10.51271/eajaic-0003.

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Aims: This study compares bupivacaine – lidocaine and levobupivacaine – lidocaine administrations in terms of initiation and duration of motor and sensorial blockage, total number of additional analgesic applications, analgesic amount consumed in 24 hours, side-effects and hemodynamic effects in continuous axillary brachial pleksus block in hand and forearm surgery. Methods: Thirty ASA I & II physical status patients, scheduled hand or forearm surgery were enrolled for of the two groups in a randomized study. Axillary catheter duly placed in both group with appropriate guided techniques. P

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Kritika, Soni. "An Observational Study to See the Effect of Instillation of Local Anaesthetic (Bupivacaine) in Gall Bladder Fossa and Trocar Incision Site I/V/O Pain Following Laproscopic Cholecystectomy." International Journal of Pharmaceutical and Clinical Research 14, no. 11 (2022): 843–48. https://doi.org/10.5281/zenodo.13879585.

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<strong>Introduction:</strong> Even though there are multiple benefits of laparoscopic cholecystectomy over the open cholecystectomy but still the postoperative pain has remained as a major issue. It is helpful to decrease the postoperative pain through the infiltration of local anesthetics like Bupivacaine inside operative wounds. The upper limit of bupivacaine is 2.5 mg per kilogram of the patient’s body weight. <strong>Aims and Objective: </strong>An observational study to see the effect of instillation of local anaesthetic (Bupivacaine) in gall bladder fossa and trocar

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Hussain, Nasir, Jarod Speer, and Faraj W. Abdallah. "Analgesic Effectiveness of Liposomal Bupivacaine versus Plain Local Anesthetics for Abdominal Fascial Plane Blocks: A Systematic Review and Meta-analysis of Randomized Trials." Anesthesiology 140, no. 5 (2024): 906–19. http://dx.doi.org/10.1097/aln.0000000000004932.

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Background Liposomal bupivacaine is reported to prolong the duration of analgesia when used for abdominal fascial plane blocks compared to plain local anesthetics; however, evidence from randomized trials is mixed. This meta-analysis aims to compare the analgesic effectiveness of liposomal bupivacaine to plain local anesthetics in adults receiving abdominal fascial plane blocks. Methods Randomized trials comparing liposomal bupivacaine and plain (nonliposomal) local anesthetics in abdominal fascial plane blocks were sought. The primary outcome was area under the curve rest pain between 24 to 7

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De Kock, Marc, Philippe Gautier, Athanassia Pavlopoulou, Marc Jonniaux, and Patricia Lavand'homme. "Epidural Clonidine or Bupivacaine as the Sole Analgesic Agent during and after Abdominal Surgery." Anesthesiology 90, no. 5 (1999): 1354–62. http://dx.doi.org/10.1097/00000542-199905000-00020.

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Background The rationale of this study was to compare high-dose epidural clonidine with a more commonly used agent, such as bupivacaine. This was performed to give a more objective idea of the relative analgesic potency of epidural clonidine. Methods Sixty patients undergoing intestinal surgery during propofol anesthesia were studied. At induction, the patients received epidurally a dose of 10 micrograms/kg [corrected] clonidine in 7 ml saline followed by an infusion of 6 micrograms [corrected] x kg(-1) x h(-1) (7 ml/h) (group 1, n = 20), a dose of 7 ml bupivacaine, 0.5%, followed by 7 ml/h bu

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Pan, L., Y. Zhang, Y. He, et al. "Dexmedetomidine elevates the lethal dose threshold of bupivacaine in rats: A dosing study." Human & Experimental Toxicology 39, no. 3 (2019): 365–73. http://dx.doi.org/10.1177/0960327119889658.

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Dexmedetomidine (DMED), an alpha-2 adrenoreceptor agonist, has been widely used in regional anesthesia procedures. However, the effect of DMED on local anesthetic cardiotoxicity has not been well delineated. This study consisted of two experiments. In experiment A, 42 Sprague–Dawley (SD) rats were randomly divided into 6 groups ( n = 7), each group was pretreated with DMED 0 μg kg−1 (D0 group), 1 μg kg−1 (D1 group), 3 μg kg−1 (D3 group), 6 μg kg−1 (D6 group), 12 μg kg−1 (D12 group), and 24 μg kg−1 (D24 group), administered through the right femoral vein. In experiment B, 20 SD rats were random

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Hiller, David B., Guido Di Gregorio, Richard Ripper, et al. "Epinephrine Impairs Lipid Resuscitation from Bupivacaine Overdose." Anesthesiology 111, no. 3 (2009): 498–505. http://dx.doi.org/10.1097/aln.0b013e3181afde0a.

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Background Lipid emulsion infusion reverses local anesthetic-induced cardiac toxicity, but the effect of adding epinephrine has not been studied. We compared escalating doses of epinephrine on recovery with lipid infusion in a rat model of bupivacaine overdose. Methods Rats anesthetized with isoflurane received an IV bolus of 20 mg/kg bupivacaine, producing asystole (zero time) in all animals. Ventilation (100% oxygen) and chest compressions were started immediately, and at 3 min the rats received one of six IV treatments (n = 5 for all groups): 5 ml/kg saline followed by infusion for 2 min at

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Pollock, Julia E., Joseph M. Neal, Carol A. Stephenson, and Carol E. Wiley. "Prospective Study of the Incidence of Transient Radicular Irritation in Patients Undergoing Spinal Anesthesia." Anesthesiology 84, no. 6 (1996): 1361–67. http://dx.doi.org/10.1097/00000542-199606000-00012.

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Background There is considerable controversy regarding the role of subarachnoid 5% hyperbaric lidocaine in the syndrome transient radicular irritation (TRI). This randomized, double-blinded, prospective study was designed to determine the incidence of TRI and identify factors possibly contributing to its development. Methods One hundred fifty-nine ASA physical status 1 or 2 patients undergoing outpatient knee arthroscopy or unilateral inguinal hernia repair were prospectively randomized to receive spinal anesthesia with 5% hyperbaric lidocaine with epinephrine (60 mg with 0.2 mg epinephrine fo

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Yudistira, Andhika, Agustinus Budhi Prasetio, Lasa Dhakka Siahaan, and Muhammad Alwy Sugiarto. "Local Anesthetics Lidocaine and Bupivacaine as Pre-emptive Analgesia in Lumbar Region Degenerative Spinal Surgery Patients with Posterior Approach." Open Access Macedonian Journal of Medical Sciences 10, B (2022): 365–68. http://dx.doi.org/10.3889/oamjms.2022.8580.

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BACKGROUND: Pain management with pre-emptive analgesia is a pain management strategy to reduce acute post-operative pain. AIM: This research aimed to determine the effectiveness of local anesthetics Lidocaine and Bupivacaine to reduce acute pain after the lumbar spine degenerative surgery using a posterior approach. METHODS: This study was observational research with a prospective cohort and was carried out in 2021 at RSUD Dr. Saiful Anwar Malang with a sample of 12 in each test. The samples obtained were in accordance with the inclusion and exclusion criteria. RESULTS: This assessment used wa

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Nouette-Gaulain, Karine, François Forestier, Monique Malgat, Roger Marthan, Jean-Pierre Mazat, and François Sztark. "Effects of Bupivacaine on Mitochondrial Energy Metabolism in Heart of Rats following Exposure to Chronic Hypoxia." Anesthesiology 97, no. 6 (2002): 1507–11. http://dx.doi.org/10.1097/00000542-200212000-00024.

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Background Adaptation to chronic exposure to hypoxia alters energy metabolism in the heart, particularly in the left ventricle, which undergoes a loss in oxidative capacity. Highly lipophilic local anesthetics interfere with mitochondrial energy metabolism. The purpose of this study was to compare the effects of bupivacaine on mitochondrial energy metabolism in heart of rats subjected to normoxic or hypoxic environments. Methods Male Wistar rats (n = 10) were subjected to hypobaric hypoxia (simulated altitude = 5,000 m, 380 mmHg) for 2 weeks. Control rats (n = 10) were maintained in an ambient

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Baig Mirza Wajeed, Manmohan Jindal, Neelima Tandon, Namrata Jain, and Mahesh Kumar Vishwakarma. "A comparative study to assess the effects of intrathecal fentanyl and intrathecal tramadol combined with 0.5% bupivacaine heavy in patients undergoing elective urological surgeries: A prospective randomized study." Asian Journal of Medical Sciences 15, no. 8 (2024): 13–20. https://doi.org/10.71152/ajms.v15i8.4094.

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Background: Urological operations frequently involve the use of spinal anesthesia. In the present scenario, adding different adjuvants to local anesthetic improve its quality and duration has become common. Aims and Objectives: In patients undergoing elective urological procedures, the purpose of this study was to assess the effects of intrathecal fentanyl or tramadol with 0.5% bupivacaine heavy. Materials and Methods: Patients were divided into two groups of 30 patients each, a total of 60 patients aged 20–60 years undergoing elective urological surgeries participated in this prospective, ran

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Baig Mirza Wajeed, Manmohan Jindal, Neelima Tandon, Namrata Jain, and Mahesh Kumar Vishwakarma. "A comparative study to assess the effects of intrathecal fentanyl and intrathecal tramadol combined with 0.5% bupivacaine heavy in patients undergoing elective urological surgeries: A prospective randomized study." Asian Journal of Medical Sciences 15, no. 8 (2024): 13–20. http://dx.doi.org/10.3126/ajms.v15i8.66316.

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Background: Urological operations frequently involve the use of spinal anesthesia. In the present scenario, adding different adjuvants to local anesthetic improve its quality and duration has become common. Aims and Objectives: In patients undergoing elective urological procedures, the purpose of this study was to assess the effects of intrathecal fentanyl or tramadol with 0.5% bupivacaine heavy. Materials and Methods: Patients were divided into two groups of 30 patients each, a total of 60 patients aged 20–60 years undergoing elective urological surgeries participated in this prospective, ran

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Oyadomari, Sarah, Wendy E. Brown, Heenam Kwon, et al. "In Vitro Effects of Bupivacaine on the Viability and Mechanics of Native and Engineered Cartilage Grafts." American Journal of Sports Medicine 49, no. 5 (2021): 1305–12. http://dx.doi.org/10.1177/0363546521995184.

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Background: Although the toxic effects of bupivacaine on chondrocyte monolayer culture have been well described, its cellular and mechanical effects on native and engineered articular cartilage remain unclear. For the repair of articular cartilage defects, fresh autologous and allogenic cartilage grafts are commonly used, and engineered cell-based therapies are emerging. The outcome of grafting therapies aimed at repairing damaged cartilage relies largely on maintaining proper viability and mechanical suitability of the donor tissues. Purpose: To investigate the in vitro effects of single bupi

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Fischer, Catherine, Pierre Blanié, Envel Jaouën, Christophe Vayssière, Ismaël Kaloul та Jean-Claude Coltat. "Ropivacaine, 0.1%, Plus Sufentanil, 0.5 μg/ml, versus Bupivacaine, 0.1%, Plus Sufentanil, 0.5 μg/ml, Using Patient-controlled Epidural Analgesia for Labor". Anesthesiology 92, № 6 (2000): 1588–93. http://dx.doi.org/10.1097/00000542-200006000-00015.

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Background This study compared the administration of 0.1% ropivacaine and 0.5 microg/ml sufentanil with that of 0.1% bupivacaine and 0.5 microg/ml sufentanil via patient-controlled epidural analgesia route during labor. Methods Two hundred healthy pregnant women at term with a single fetus with a vertex fetal presentation were randomized in a double-blind fashion to receive either 0.1% ropivacaine and 0.5 microg/ml sufentanil or 0.1% bupivacaine and 0.5 microg/ml sufentanil using a patient-controlled epidural analgesia pump (5-ml bolus dose, 10-min locked-out period, no basal infusion). Pain s

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Dr, Mokhalad Hikmat Ameen, Luay Badr Hasan Dr, and Mohammed Sabah Saber Dr. "Comparison between Intrathecal Fentanyl and Ketamine as an Add-On to Heavy Bupivacaine for Cesarian Section." Sarcouncil journal of Medical sciences 3, no. 6 (2024): 33–41. https://doi.org/10.5281/zenodo.12000430.

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Background: Obstetric anesthesia is demanding but gratifying subspecialty of anesthesiologist. Anesthetic care of pregnant patient is unique in that two patients are cared for simultaneously; the parturient and the fetus. Aim of Study: The aim of our study was to compare between the two preparations and also to know if one preparation has advantage over the other regarding the onset, duration and recovery of sensory and motor blocked, duration of analgesia, hemodynamics changes, respiratory changes, and incidence of side effects Patients and Methods: A randomized double blinded controlled&nbsp

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Lindner, Dror, Ron Gilat, Yossi Smorgick, Erez Avisar, Gabriel Agar, and Yiftah Beer. "Efficacy of Intra-articular Versus Extra-articular Bupivacaine Injection in Arthroscopic Partial Meniscectomy: A Prospective, Randomized, Double-Blind Clinical Trial." Orthopaedic Journal of Sports Medicine 11, no. 4 (2023): 232596712211475. http://dx.doi.org/10.1177/23259671221147514.

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Background: Immediate postoperative pain relief following arthroscopic partial meniscectomy remains a critical contributor to improved patient experience, early recovery of range of motion, and enhanced rehabilitation. Purpose: To evaluate the effect of intra-articular versus extra-articular bupivacaine on pain intensity and analgesic intake after arthroscopic partial meniscectomy. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: This was a prospective double-blind, randomized clinical trial. All patients included underwent arthroscopic partial meniscectomy under gener

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Curatolo, Michele, Thomas W. Schnider, Steen Petersen-Felix, et al. "A Direct Search Procedure to Optimize Combinations of Epidural Bupivacaine, Fentanyl, and Clonidine for Postoperative Analgesia." Anesthesiology 92, no. 2 (2000): 325. http://dx.doi.org/10.1097/00000542-200002000-00012.

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Background The authors applied an optimization model (direct search) to find the optimal combination of bupivacaine dose, fentanyl dose, clonidine dose, and infusion rate for continuous postoperative epidural analgesia. Methods One hundred ninety patients undergoing 48-h thoracic epidural analgesia after major abdominal surgery were studied. Combinations of the variables of bupivacaine dose, fentanyl dose, clonidine dose, and infusion rate were investigated to optimize the analgesic effect (monitored by verbal descriptor pain score) under restrictions dictated by the incidence and severity of

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Chen, Ying, Yun Xia, Le Liu, et al. "Lipid Emulsion Reverses Bupivacaine-induced Asystole in Isolated Rat Hearts." Anesthesiology 113, no. 6 (2010): 1320–25. http://dx.doi.org/10.1097/aln.0b013e3181fc63ed.

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Background The concentration-response and time-response relationships of lipid emulsions used to reverse bupivacaine-induced asystole are poorly defined. Methods Concentration response across a range of lipid concentrations (0-16%) to reverse bupivacaine-induced asystole were observed using isolated rat heart Langendorff preparation. Cardiac function parameters were recorded during infusion. Concentrations of bupivacaine in myocardial tissue were measured by liquid chromatography and tandem mass spectrometry at the end of the experiment. Results Although all lipid-treated hearts recovered (car

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Senapati, Laxman K., and Priyadarsini Samanta. "EFFECT OF INTRAVENOUS VERSUS INTRATHECAL DEXMEDETOMIDINE ON CHARACTERISTICS OF HYPERBARIC BUPIVACAINE SPINAL ANESTHESIA IN LOWER LIMB SURGERY." Asian Journal of Pharmaceutical and Clinical Research 11, no. 7 (2018): 427. http://dx.doi.org/10.22159/ajpcr.2018.v11i7.26096.

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Objectives: Dexmedetomidine was shown to prolong the duration of spinal anesthesia and enhance post-operative analgesia. The aim of the study was to compare the effect of intravenous (IV) versus intrathecal (IT) administration of dexmedetomidine on bupivacaine spinal anesthesia in patients undergoing lower limb surgery.Methods: A prospective randomized controlled study was conducted during the year 2014–15. 60 American Society of Anesthesiologists physical status I–II aged 18–60 years scheduled for lower limb surgery under spinal anesthesia were assigned randomly to two groups: (1) IT group (I

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Dhokarikar, Pradnya, Dennis D. Caywood, Daniel Stobie, et al. "Effects of intramuscular or interpleural administration of morphine and interpleural administration of bupivacaine on pulmonary function in dogs that have undergone median sternotomy." American Journal of Veterinary Research 57, no. 3 (1996): 375–80. http://dx.doi.org/10.2460/ajvr.1996.57.03.375.

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Abstract Objective To evaluate effects of interpleural or IM administration of morphine and interpleural administration of bupivacaine on pulmonary function in dogs that have undergone median sternotomy. Design Experimental trial. Animals 18 healthy dogs. Procedure Dogs underwent median sternotomy and were randomly assigned to groups of 6 dogs each. Group-A dogs were given morphine (1.0 mg/kg of body weight) IM; group-B dogs were given 0.5% bupivacaine (1.5 mg/kg) interpleurally; and group-C dogs were given morphine (1.0 mg/kg) interpleurally. Heart rate; systolic, diastolic, and mean arterial

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Hussien, Rania Maher, Osama Medhat Ragab Abdelrehem, Yassmin Hassan Abd El Sattar, and Rami Mounir Wahba Gobrane. "Efficacy of Dexmedetomidine as Adjuvant to Intrathecal Bupivacaine in Decreasing Incidence of Post Spinal Shivering in Parturient Undergoing Caesarean Section." Anaesthesia, Pain & Intensive Care 29, no. 4 (2025): 301–7. https://doi.org/10.35975/apic.v29i4.2600.

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Background & objective: Shivering is one of the common troublesome complications following regional anesthesia, which causes much discomfort to the patient, besides its adverse effects on the oxygenation and hemodynamic parameters. It may interfere with pulse oximetry and electrocardiogram monitoring. It can also increase oxygen demand. Various pharmacological and non-pharmacological measures have been used to prevent and/or control shivering. We conducted this study to observe if addition of dexmedetomidine to the spinal bupivacaine for cesarean section will offer better results as compar

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Wong, Cynthia A., Barbara M. Scavone, Mariann Loffredi, Warren Y. Wang, Alan M. Peaceman, and Jeanne N. Ganchiff. "The Dose–Response of Intrathecal Sufentanil Added to Bupivacaine for Labor Analgesia." Anesthesiology 92, no. 6 (2000): 1553–58. http://dx.doi.org/10.1097/00000542-200006000-00011.

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Background Regional analgesia for labor often is initiated with an intrathecal injection of a local anesthetic and opioid. The purpose of this prospective, randomized, blinded study was to determine the optimal dose of intrathecal sufentanil when combined with 2.5 mg bupivacaine for labor analgesia. Methods One hundred seventy parous parturients with cervical dilation between 3-5 cm were randomized to receive intrathecal 0 (control), 2.5, 5.0, 7.5, or 10.0 microg sufentanil combined with 2.5 mg bupivacaine, followed by a lidocaine epidural test dose, for initiation of analgesia (34 patients in

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Bjerregaard, Nils, Lone Nikolajsen, Thomas Fichtner Bendtsen, and Bodil Steen Rasmussen. "Transversus Abdominis Plane Catheter Bolus Analgesia after Major Abdominal Surgery." Anesthesiology Research and Practice 2012 (2012): 1–5. http://dx.doi.org/10.1155/2012/596536.

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Purpose. Transversus abdominis plane (TAP) blocks have been shown to reduce pain and opioid requirements after abdominal surgery. The aim of the present case series was to demonstrate the use of TAP catheter injections of bupivacaine after major abdominal surgery.Methods. Fifteen patients scheduled for open colonic resection surgery were included. After induction of anesthesia, bilateral TAP catheters were placed, and all patients received a bolus dose of 20 mL bupivacaine 2.5 mg/mL with epinephrine 5 μg/mL through each catheter. Additional bolus doses were injected bilaterally 12, 24, and 36

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Liu, Spencer S., Hugh W. Allen, and Gayle L. Olsson. "Patient-controlled Epidural Analgesia with Bupivacaine and Fentanyl on Hospital Wards." Anesthesiology 88, no. 3 (1998): 688–95. http://dx.doi.org/10.1097/00000542-199803000-00020.

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Background The efficacy and safety of patient-controlled epidural analgesia (PCEA) for postoperative analgesia on hospital wards was studied. Methods Postoperative analgesia was provided for 1,030 patients with PCEA using 0.05% bupivacaine and fentanyl, 4 microg/ml, in a standardized manner. Patients were seen at least twice a day by the staff of the anesthesia pain management service. Prospectively gathered data included verbal pain scores at rest and activity (0-10); consumption of bupivacaine and fentanyl; and incidences of pruritus, nausea, sedation, hypotension, motor block, and respirato

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Shrestha, I. N., G. P. Deo, S. K. Shrestha, S. Neupane, and B. S. Regmi. "Epidural tramadol improves the quality of pain relief during labor." Journal of Chitwan Medical College 6, no. 3 (2017): 14–19. http://dx.doi.org/10.3126/jcmc.v6i3.16694.

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To study the analgesic efficacy and side effects of Tramadol for painless labor in combination with Bupivacaine. Randomized, controlled, double blind, open prospective study conducted at Department of Obstetrics and Gynaecology, Chitwan Medical College from July 1st 2015 to June 30th 2016. 100 patients of ASA Grade I and II, aged between 20-35 years willing for epidural analgesia for labor pain were included in the study. They were divided into two groups: Group A- Control group and Group B- Study group. Subjects of Group A received 10 ml of 0.25% Bupivacaine and that of Group B received 10ml

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Bhanu, Prakash, Singh Nidhi, and Sharma Kiran. "Effectiveness of 0.5% Levobupivacaine and 0.75 % Ropivacaine for Epidural Anesthesia for Elective Lower Limb Orthopedic Surgeries: A Retrospective Study." International Journal of Toxicological and Pharmacological Research 14, no. 3 (2024): 265–69. https://doi.org/10.5281/zenodo.12820420.

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<strong>Aim: </strong>The aim of the present study was to compare the effectiveness of 0.5% Levobupivacaine and 0.75% Ropivacaine for epidural anesthesia for elective lower limb orthopedic surgeries. <strong>Methods: </strong>This study was performed at Shree Narayan Medical Institute and Hospital, Saharsa, Bihar, India for one year. Subjects included sixty adult patients (age between 18 and 55 years), scheduled to undergo orthopedic surgery of lower extremity. All patients were in ASA class I and II. <strong>Results: </strong>There were male predominance and most of t

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Khan, Shehryar Alam, Gulraiz Zulfiqar, and Ayesha Binte Aslam. "Efficacy of Bupivacaine Inferior Alveolar Nerve Block Versus Intravenous Use of Tramadol for Postoperative Pain Control in Mandibular Parasymphysis Fractures." Pakistan Journal of Medical and Health Sciences 17, no. 3 (2023): 689–92. http://dx.doi.org/10.53350/pjmhs2023173689.

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Background: One of the most crucial parts of any operation is postoperative monitoring and management. Numerous clinical strategies for administering analgesic drugs have been developed to reduce postoperative pain in patients. High opioid doses before, during, and after surgery might cause respiratory depression, sleepiness, nausea, vomiting, itching, difficulties urinating, and ileus. Most surgeries cause maxillo-mandibular fixation (locked jaw). In the early postoperative period, ventilatory depression and vomiting are common that’s why this study focuses on the two types of drug interventi

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Rupesh, Kumar Mishra, and Kumar Krishna. "Comparison of Intrathecal Dexmedetomidine, Clonidine, and Fentanyl as Adjuvants to Hyperbaric Bupivacaine for Lower Limb Surgery at SKMCH, Muzaffarpur, Bihar." International Journal of Pharmaceutical and Clinical Research 16, no. 5 (2024): 1960–65. https://doi.org/10.5281/zenodo.12802593.

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<strong>Background:</strong> Various adjuvants are being used with local anesthetics for prolongation of intraoperative and postoperative analgesia. Dexmedetomidine, the highly selective 2 adrenergic agonist is a new neuraxial adjuvant gaining popularity. <strong>Aim:</strong> The purpose of this study was to compare the onset, duration of sensory and motor block, hemodynamic effects, postoperative analgesia, and adverse effects of dexmedetomidine, clonidine, and fentanyl used intrathecally with hyperbaric 0.5% bupivacaine for spinal anesthesia. <strong>Methods:</strong>&nb

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Digraskar, Vinod Devidasrao, Prem Raj Singh, Sukriti Xess, Akansha Jain, and Dnyanesh Kashikar. "HEMODYNAMICS EFFECT OF BUPIVACAINE AND LEVOBUPIVACAINE IN PAEDIATRIC ABDOMINAL SURGERIES." Era's Journal of Medical Research 9, no. 2 (2022): 150–55. http://dx.doi.org/10.24041/ejmr2022.25.

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Regional analgesia features a prime role within the multimodal analgesia approach for surgical pain management. currently each day it's common apply of using transverses abdominis plane block (TAP Block) with numerous sorts of native anaesthetics and adjuvants, as a multimodal pain relieving remedy used worldwide for intra and postoperative pain management in several surgeries. However, only a few studies are done wherever hemodyanamics effects when bupivacaine versus levobupivacaine have compared. Aim of this study to examine the consequences of bupivacaine vs levobupivacaine in patients unde

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Moorman, Valerie J., Lynn M. Pezzanite, and Gregg M. Griffenhagen. "Liposomal bupivacaine provides longer duration analgesia than bupivacaine hydrochloride in an adjustable sole-pressure model of equine lameness." American Journal of Veterinary Research 83, no. 4 (2022): 298–304. http://dx.doi.org/10.2460/ajvr.21.08.0132.

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Abstract OBJECTIVE To compare the efficacy and duration of action for perineural analgesia with liposomal bupivacaine (LB) versus bupivacaine hydrochloride (BHCl) in a sole-pressure induced model of forelimb lameness in horses. ANIMALS 6 healthy adult research horses. PROCEDURES In 1 randomly assigned forelimb, grade 3/5 lameness was induced by use of a sole-pressure lameness model. Objective lameness (vector sum [VS]) was determined with an inertial sensor system at 0, 1, 6, and 24 hours after lameness induction to evaluate the model. Mechanical nociceptive thresholds (MNTs) and objective lam

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Durnev, Vesna, Marija Soljakova, Venko Filipce, Maja Mojsova Mijovska, and Marina Temelkovska Stevanovska. "Hemodynamic and Bispectral Changes During Pin Insertion in Craniotomy – Effect of Locally Infiltrated Bupivacaine." PRILOZI 38, no. 2 (2017): 115–21. http://dx.doi.org/10.1515/prilozi-2017-0029.

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Abstract Introduction Cranial pins insertion is a method for head stabilization and together with the scalp incision is one of the biggest noxious stimulus associated with arousal and rapid increase of the blood pressure leading to pathological increase of the intracranial pressure. The aim of this investigation is to study the superiority of the locally infiltrated anesthetic bupivacaine just before the skull pin insertion and the scalp incision in craniotomy under general anesthesia. Methods In the study thirty patients of both genders aged 24-72 years were included. They were categorized as

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Dipti, N. Desai, N. Kanabar Hetal, C. Babariya Dinesh, Mary Priyanka J, and M. Vania Kanvee. "Comparative Study of Analgesic Effect of Intrathecal Administration of Dexmedetomidine and Fentanyl as Adjuvants to Bupivacaine in Lower Limb Ilizarov Surgeries." International Journal of Pharmaceutical and Clinical Research 16, no. 3 (2024): 254–57. https://doi.org/10.5281/zenodo.10955966.

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<strong>Background:</strong> In present day anesthesia practice various drugs has been used for a better somatic and visceral analgesia as adjuvants along with local anesthetic drug given in spinal anesthesia. <strong>Aim: </strong>The main aim of the study was to compare efficacy, safety, hemodynamic stability and analgesic effect of intrathecal dexmedetomidine and fentanyl as adjuvants to hyperbaric 0.5% bupivacaine in lower limb Ilizarov surgeries. <strong>Materials and Methods:</strong> Study was done taking 60 no. of patients who were classified under American soc

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Martin, Miriam S., Michael Kleinhenz, Abbie Viscardi, et al. "179 A Comparison of Local Anesthetic Effectiveness in Reducing Pain Associated with Dehorning in Dairy Calves." Journal of Animal Science 99, Supplement_1 (2021): 2–3. http://dx.doi.org/10.1093/jas/skab054.003.

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Abstract Dehorning is performed on a high percentage of dairies in the United States. Concern for animal welfare has led to investigating pain mitigation during dehorning. The objective was to compare the effectiveness of bupivacaine liposome suspension, lidocaine, or lidocaine + meloxicam administered at dehorning. Fifty male Holstein calves, 10–14 weeks of age were enrolled and randomly assigned to 1 of 5 treatment groups: 1) bupivacaine liposome suspension block, oral placebo, cautery dehorn (BUP); 2) lidocaine block, oral placebo, cautery dehorn (LID); 3) lidocaine block, oral meloxicam, c

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Chaudhary, Rahul Kumar, Sajjad Ahmed Khan, Kanak Khanal, et al. "A deep dive into neonatal well-being and anesthesia in cesarean sections: From procedure to outcome." Medicine 103, no. 44 (2024): e40404. http://dx.doi.org/10.1097/md.0000000000040404.

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This observational study analyzed data from 502 participants undergoing cesarean section (CS) procedures at an obstetrics and gynecology department, aiming to explore anesthesia practices, neonatal outcomes, and demographic characteristics within the cohort. Participants, aged 17 to 59 years with a mean age of 32.23 years, were enrolled based on the clinical necessity for cesarean delivery during the study period. Informed consent was obtained from each participant or their guardians before data collection, which included detailed demographic information, medical histories, specifics of the ce

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Pokharel, Sangam, Rajesh Yadav, Anima Pradhan, and Ashmita Paudel. "Comparative Study of Bupivacaine 0.5% and Ropivacaine 0.75% Epidurally In Lower Limb Orthopedic Surgeries." Dinkum Journal of Medical Innovations 3, no. 02 (2024): 165–73. https://doi.org/10.71017/djmi.3.2.d-0248.

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The epidural blockade is becoming one of the most useful and versatile procedures in modern anesthesiology as it provides effective surgical anesthesia. In equal concentrations, the degree of motor blockade is less pronounced with Ropivacaine, and there is a greater propensity for blocking pain transmitting A-delta and C fibers rather than A-α motor fibers and an effective alternate to epidural Bupivacaine for major lower limb orthopedic surgery. This prospective, randomized, double blind study performed on N=60 patients of department of Anesthesiology, College of Medical Sciences-Teaching Hos

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Dr., Muhammad Ahmad Khan Dr. Muhammad Hassan Yousaf Dr. M. Talha Khan. "CLONIDINE BY WAY OF ADJUVANT FOR BUPIVACAINE INSIDE CAUDAL PAINLESSNESS FOR SUB-UMBILICAL OPERATION." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 06 (2019): 11994–97. https://doi.org/10.5281/zenodo.3246879.

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<strong><em>Background & Objectives: </em></strong><em>Caudal painlessness remains acknowledged in addition widespread technique of providing intra also Post-operatively numbness for stomach, perineal also inferior appendage operations in broods. Caudal epidural chunk through bupivacaine remains single of maximum recognized local painkilling procedure exercised in offspring. Numerous assistants just like opioids, ketamine, also neostigmine was exercised through bupivacaine to extend their act also therefore spread period of post-operatively numbness provided through ‘solo shot’

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Shaheen, Md Shafiul Alam, Md Khalilur Rahman, Kawsar Sardar, et al. "The Comparative Study of Epidural Levobupivacaine and Bupivacaine in Major Abdominal Surgeries in Type- 2 Diabetic Patient." Journal of the Bangladesh Society of Anaesthesiologists 30, no. 1 (2017): 5–13. http://dx.doi.org/10.3329/jbsa.v30i1.65309.

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Background: Major abdominal surgeries still induce neurohumoral changes responsible for postoperative pain, various organ dysfunctions, prolong hospitalization and convalescence. Insufficient pain therapy prolongs the hospital stay and rises the mortality rates. Epidural analgesia confers excellent pain relief and complete dynamic analgesia leading to a substantial reduction in the surgical stress response. Opioid and local anaesthetic infusion by an epidural catheter is widely used as a postoperative pain management method after major abdominal surgeries. Type-2 Diabetic patient has many como

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Soliman, Fouad I., Elhadad A. Mousa, Shehab M. Ahmed, and Ahmed H. Hassan. "Intrathecal atropine versus preoperative intravenous ondasetron for prevention of postoperative nausea and vomiting due to intrathecal morphine in perineal surgery." Research and Opinion in Anesthesia & Intensive Care 10, no. 3 (2023): 271–78. http://dx.doi.org/10.4103/roaic.roaic_24_23.

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Background Opioids are frequently added to neuroaxial local anesthetics (LAs). Intrathecal (IT) opioid is not devoid of adverse effects such as postoperative nausea and vomiting (PONV), respiratory depression, and pruritis. IT atropine also carries a significant antiemetic effect, and this can be a valuable modality for the prevention of IT opioid-related PONV. The antagonist of 5-HT3 receptors such as ondasetron which is usually used to decrease the incidence of nausea and vomiting was considered for the prevention and treatment of neuroaxial opioid-induced (PONV). Method 100 cases of ASA I-I

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Mercier, Frederic J., Mokhtar Dounas, Herve Bouaziz, et al. "The Effect of Adding a Minidose of Clonidine to Intrathecal Sufentanil for Labor Analgesia." Anesthesiology 89, no. 3 (1998): 594–601. http://dx.doi.org/10.1097/00000542-199809000-00007.

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Background Preliminary studies have suggested that the addition of clonidine to intrathecal sufentanil prolongs analgesia without producing motor blockade. Methods Fifty-three nulliparous women in painful labor were included in this prospective, randomized, double-blinded study. Parturients at 2- to 5-cm cervical dilation received either 5 microg sufentanil plus 30 microg clonidine or 5 microg sufentanil intrathecally, followed by 5 mg bupivacaine epidurally. The primary outcome was time until first request for additional analgesia. Visual analog pain scores, sensory changes, blood pressure, h

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Dr.Amna, Tariq Muhammad Osama Shabbir Dr Rana Mahmood Khurshid. "A RANDOMIZED CONTROL TRIAL TO INSPECT THE MERITS AND EFFICACY OF PREEMPTIVE USG STEERED SINGLE INFUSION RECTUS SHEATH SQUARE." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 08 (2019): 14787–90. https://doi.org/10.5281/zenodo.3370303.

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<strong><em>Background: </em></strong><em>Laparoscopic tubal ligation (LTL) is multi day care medical procedure and requires a little supraumbilical entry point for the umbilical port. Torment after LTL is more than indicative laparoscopy.</em> <strong><em>Objective: </em></strong><em>Our objective was to inspect the adequacy and advantages of a preemptive ultrasound guided single infusion rectus sheath square (RSB) in giving improved right off the bat postoperative agony scores in contrast with general anesthesia alone. </em> <strong><em>Place and Time of study:</em></strong><em> Sir Ganga Ra

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Brennan, Timothy J., Eric F. Umali, and Peter K. Zahn. "Comparison of Pre- versus Post-incision Administration of Intrathecal Bupivacaine and Intrathecal Morphine in a Rat Model of Postoperative Pain." Anesthesiology 87, no. 6 (1997): 1517–28. http://dx.doi.org/10.1097/00000542-199712000-00031.

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Background Preclinical studies in experimental animals suggest that preemptive analgesia may improve postoperative pain management. The beneficial effects of preemptive analgesia appear less remarkable clinically. The purpose of this study is to examine the effect of pre- and post-incision administration of intrathecal bupivacaine and intrathecal morphine in a rat model for postoperative pain. Methods Rats with intrathecal catheters were anesthetized with halothane, and the surgical field was prepared. A saline vehicle or the test drug was administered 15 min before an incision was made in the

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Ahmad, Anees, Ambreen Khan, Syed Shakeel Ahmed, Saima Noreen, Mohammad Idrees, and Shahryar. "Post-operative Analgesia with Intraperitoneal Bupivacaine Alone and with Dexmedetomidine Following Laparoscopic Cholecystectomy." Pakistan Journal of Medicine and Dentistry 14, no. 1 (2025): 39–46. https://doi.org/10.36283/ziun-pjmd14-1/007.

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Background: Laparoscopic cholecystectomy (LC) is a customary treatment for patients with symptomatic cholelithiasis. This study aimed to compare the mean duration of analgesia (DOA) of intraperitoneal bupivacaine (BPV) with dexmedetomidine (DEX) to intraperitoneal BPV alone in patients undergoing LC. Methods: This randomized controlled trial was done at the Department of Anesthesiology, Bahawalpur Victoria Hospital, Bahawalpur, Pakistan, from October 2023 to March 2024. A simple random sampling technique was adopted. A total of 68 cases undergoing LC were enrolled and randomly allocated to eit

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Tri Badi, Sulastri Sulastri, and Immanuel Rianto Sitorus. "Gambaran Lama Kerja Analgesi Pada Spinal Anestesi Menggunakan Bupivakain 0,5 % Hiperbarik 12,5mg Dengan Tambahan Morfin 0,2 Mg Terhadap Waktu Respon Nyeri Pasien Pasca Sectio Caesarea Di RS Vita Insani." JURNAL RISET RUMPUN ILMU KESEHATAN 1, no. 1 (2022): 195–200. http://dx.doi.org/10.55606/jurrikes.v1i1.1976.

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The combination of low-dose intrathecal morphine with spinal anesthesia provides an effective and safe postoperative analgesia effect and may enhance the analgesia effect of bupivacaine. At Vita Insani Hospital, almost all patients who will undergo S.C surgery are generally carried out with spinal anesthesia by an anesthesiologist with habitual drug use and the dose used is bupivacaine 0.5% hyperbaric 12.5 mg plus adjuvant morphine 0.2 mg. Seeing the phenomenon of this case, the researcher wanted to see how the description of the effect of giving bupivacaine 0.5% hyperbaric 12.5 mg plus adjuva

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