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Journal articles on the topic '003.26:621.39 (043.3)'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Aguirre, Luis E., Jan Philipp Bewersdorf, Yiwen Liu, et al. "Comparative Analysis of Outcomes with HMA Plus Venetoclax Vs Intensive Chemotherapy in AML Patients Harboring Very-High Risk Cytogenetics." Blood 144, Supplement 1 (2024): 4267. https://doi.org/10.1182/blood-2024-202744.

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Background: Dismal survival outcomes are characteristic of pts with AML harboring very-high risk cytogenetics (vHRC), which can be attributed to aggressive disease biology and low and poorly durable response rates to conventional cytotoxic chemotherapy. Allogeneic hematopoietic stem cell transplant (alloSCT) is the preferred treatment strategy after major disease reduction with initial chemotherapy. However, it is unclear whether pts with AML-vHRC should be treated with intensive chemotherapy (IC) or hypomethylating agents plus venetoclax (HMA+ven) to achieve such responses. In this large mult

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Calvo Garcia, A., N. García Castañeda, C. Valero, et al. "AB0334 COST-EFECTIVENESS OF JAK INHIBITORS IN RHEUMATOID ARTHRITIS IN THE REAL WORL PRACTICE." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1465.1–1466. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4982.

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Background:The Janus Kinase (JAK) inhibitors Baricitinib (BAR) and Tofacitinib (TOF), both in monotherapy or in combination with methotrexate, are indicated for moderate to severe active rheumatoid arthritis (RA) with inadequate response to conventional synthetic disease modifying anti-rheumatic drugs (csDMARD). Data about cost-effectiveness in a real-world setting are still scarce.Objectives:To assess the cost-effectiveness (C-E) of BAR and TOF in patients with RA in usual clinical practice.Methods:Retrospective observational study of adult RA patients who started BAR and TOF between Septembe

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Arndt, C. A., D. S. Hawkins, J. A. Stoner, et al. "Randomized phase III trial comparing vincristine, actinomycin, cyclophosphamide (VAC) with VAC/V topotecan/cyclophosphamide (TC) for intermediate risk rhabdomyosarcoma (IRRMS). D9803, COG study." Journal of Clinical Oncology 25, no. 18_suppl (2007): 9509. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.9509.

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9509 Background: IRRMS was defined as nonmetastatic alveolar (A) RMS or undifferentiated sarcoma (UDS); stage (stg) 2 and 3, group (gr) III embryonal (E) RMS; stg 4 ERMS <10y. IRRMS had a 5 yr failure free survival (FFS) of 64% on IRS IV. Since T alone and with C has significant activity in RMS, we tested whether alternating VAC/VTC improved FFS for IRRMS compared with VAC alone. Methods: Patients (pts) < 50 y with IRRMS with adequate organ function were randomized to 39 wks of VAC (V=1.5 mg/m2, A=0.045 mg/kg, C=2.2 g/m2 q 3 wk) vs VAC alternating with VTC (T=0.75 mg/m2/d ×5, C=250 mg/m2

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Issa, Ghayas C., Hagop M. Kantarjian, C. Cameron Yin, et al. "Prognostic Implications of Pre-Treatment Hypodiploidy and Complex Cytogenetics in Adult Patients with Acute Lymphocytic Leukemia (ALL) Treated with Hyper-CVAD." Blood 126, no. 23 (2015): 4874. http://dx.doi.org/10.1182/blood.v126.23.4874.4874.

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Abstract Background Pretreatment cytogenetic analysis is frequently used to predict response and outcome in hematologic malignancies. Hypodiploidy is associated with a poor prognosis in childhood ALL. Similarly, complex cytogenetics is a known adverse prognostic factor in myeloid malignancies. The impact of hypodiploidy and complex cytogenetics has not been extensively assessed in adult patients with ALL. To address this issue, we have conducted a retrospective analysis of all adult patients with ALL treated with frontline Hyper-CVAD based regimens at our institution. Methods We reviewed 332 a

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Angeles-Han, S., A. Cassedy, T. Hennard, et al. "POS1303 METHOTREXATE RESPONSE IN PEDIATRIC NON-INFECTIOUS UVEITIS." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 989–90. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1473.

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BackgroundChildren with chronic non-infectious uveitis (NIU) are at risk for sight-threatening complications. Methotrexate (MTX) is the preferred first-line systemic treatment. Initial therapeutic response takes 3-6 months to achieve NIU control, leading to prolonged glucocorticoid use. Moreover, at least 50-70% of children fail to fully respond and may accrue ocular damage while awaiting MTX response.ObjectivesTo identify features of children with NIU that are associated with MTX failure.MethodsWe included children who started MTX monotherapy for NIU. We collected demographics, NIU features (

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Enright, Thomas L., Jacob B. Leary, Dimitra R. Bakaloudi, et al. "Abstract 3402: Number of variants of unknown significance (VUS) by next generation sequencing (NGS) and response to systemic therapies in advanced urothelial carcinoma (aUC)." Cancer Research 85, no. 8_Supplement_1 (2025): 3402. https://doi.org/10.1158/1538-7445.am2025-3402.

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Abstract Background: NGS is routinely used in aUC to identify clinically actionable alterations. NGS assays tier variants by the likelihood of clinical significance, reporting both pathogenic variants and VUS. The number of VUS may serve as a rough estimate for neoantigen load, e.g. tumor mutational burden (TMB). We hypothesized that the number of VUS may represent an easy-to-use biomarker associated with response and overall survival (OS) with certain therapies e.g. immune checkpoint inhibitors (ICI). Methods: We conducted a retrospective study from patients (pts) from a single academic cente

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Tagawa, Scott T., Arjun V. Balar, Daniel P. Petrylak, et al. "Updated outcomes in TROPHY-U-01 cohort 1, a phase 2 study of sacituzumab govitecan (SG) in patients (pts) with metastatic urothelial cancer (mUC) that progressed after platinum (PT)-based chemotherapy and a checkpoint inhibitor (CPI)." Journal of Clinical Oncology 41, no. 6_suppl (2023): 526. http://dx.doi.org/10.1200/jco.2023.41.6_suppl.526.

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526 Background: SG is an antibody-drug conjugate composed of an anti-Trop-2 antibody coupled to SN-38, a topoisomerase-I inhibitor, via a proprietary hydrolyzable linker. SG received accelerated FDA approval in April 2021 in pts with mUC who previously received PT-based therapy and a CPI based on the primary analysis of the pivotal TROPHY-U-01 Cohort 1 study. With 9.1 mo median (med) follow-up, SG monotherapy demonstrated a 27% objective response rate (ORR) and med overall survival (OS) of 10.9 mo in 113 pts with locally advanced or mUC progressing after receiving at least a PT-based therapy a

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Вигівська, Л. М., І. В. Майданник, О. О. Чорна, Н. М. Гичка, В. М. Комар та К. В. Коливанова. "ВПЛИВ ЗАПРОПОНОВАНОГО ЛІКУВАЛЬНО-ПРОФІЛАКТИЧНОГО КОМПЛЕКСУ НА СИСТЕМУ ГЕМОСТАЗУ, ЕНДОТЕЛІАЛЬНОГО ТА ІМУННОГО СТАТУСУ У ВАГІТНИХ ПІСЛЯ ДОПОМІЖНИХ РЕПРОДУКТИВНИХ ТЕХНОЛОГІЙ". Актуальні питання педіатрії, акушерства та гінекології, № 2 (22 січня 2025): 32–37. https://doi.org/10.11603/24116-4944.2024.2.14987.

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Мета дослідження – визначити стан системи гемостазу, ендотеліальних факторів у жінок після застосування допоміжних репродуктивних технологій (ДРТ) на тлі запропонованого лікувально-профілактичного комплексу. Матеріали та методи. Проведено проспективне обстеження 299 вагітних, яких відповідно до типу непліддя та менеджменту поділено на: І група – 94 жінок із трубно-перитонеальним фактором непліддя; ІІ група – 87 жінок з ендокринним фактором непліддя; ІІІ група – 68 жінок із чоловічим фактором непліддя. Контрольну групу сформовано з 50 вагітних зі спонтанним настанням та фізіологічним перебігом

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Tesfaye, Solomon, Gordon Sloan, Jennifer Petrie, et al. "Optimal pharmacotherapy pathway in adults with diabetic peripheral neuropathic pain: the OPTION-DM RCT." Health Technology Assessment 26, no. 39 (2022): 1–100. http://dx.doi.org/10.3310/rxuo6757.

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Background The mainstay of treatment for diabetic peripheral neuropathic pain is pharmacotherapy, but the current National Institute for Health and Care Excellence guideline is not based on robust evidence, as the treatments and their combinations have not been directly compared. Objectives To determine the most clinically beneficial, cost-effective and tolerated treatment pathway for diabetic peripheral neuropathic pain. Design A randomised crossover trial with health economic analysis. Setting Twenty-one secondary care centres in the UK. Participants Adults with diabetic peripheral neuropath

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Christen, Deborah, Johannes Lübke, Anne Kaiser, et al. "Allogeneic Hematopoietic Stem Cell Transplantation in Advanced Systemic Mastocytosis." Blood 142, Supplement 1 (2023): 3605. http://dx.doi.org/10.1182/blood-2023-178304.

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Purpose Advanced systemic mastocytosis (AdvSM) is driven by the KIT D816V mutation in &gt;90% of patients (pts.). Depending on subtype, median survival is between 1.5 and 4 years. Despite recent advances on responses and survival due to the availability of effective KIT inhibitors, allogeneic hematopoietic stem cell transplantation (alloHSCT) remains the only curative treatment option. Data on optimal timing, conditioning regimens, and pre- as well as post-alloHSCT treatments for maintenance or relapse are however scarce. Current recommendations mainly refer to a retrospective analysis pub

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Loscocco, Giuseppe Gaetano, Paola Guglielmelli, Carmela Mannarelli, et al. "A JAK2V617F Variant Allele Frequency Greater Than 50% Identifies Patients with Polycythemia Vera at High Risk for Venous Thrombosis." Blood 138, Supplement 1 (2021): 237. http://dx.doi.org/10.1182/blood-2021-147869.

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Abstract Background: Thrombosis is the main cause of morbidity and mortality in pts with Polycythemia Vera (PV). Current risk stratification is based on 2 variables: age &gt;60y and history of thrombosis. Additional thrombotic risk factors in PV are generic cardiovascular risk factors and leukocytosis. JAK2V617F (JAK2VF) variant allele frequency (VAF) at diagnosis is highly heterogeneous. A VAF&gt;75% was associated with higher rate of all thrombosis after diagnosis (Vannucchi AM et al, Leukemia 2007), and a VAF ≥ 60% correlated with increased rate of venous thrombosis (VT) in high-ris

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Magnus, Dan, Santosh Bhatta, and Julie Mytton. "432 Establishing injury surveillance in emergency departments in Nepal: epidemiology and burden of paediatric injuries." Emergency Medicine Journal 37, no. 12 (2020): 825.2–827. http://dx.doi.org/10.1136/emj-2020-rcemabstracts.7.

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Aims/Objectives/BackgroundGlobally, injuries cause more than 5 million deaths annually. Children and young people are a particularly vulnerable group and injuries are the leading cause of death in people aged 5–24 years globally and a leading cause of disability.In most low and middle-income countries where the majority of global child injury burden occurs, systems for routinely collecting injury data are limited. There is a continuing need for better data on childhood injuries and for injury surveillance.The aim of our study was to introduce a hospital-based injury surveillance tool – the fir

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Wesseling, Jelle. "Abstract F1-2: Clonal evolution of DCIS to invasion." Cancer Research 83, no. 5_Supplement (2023): F1–2—F1–2. http://dx.doi.org/10.1158/1538-7445.sabcs22-f1-2.

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Abstract Clonal evolution of DCIS to invasion Ductal carcinoma in situ (DCIS) is the most common form of preinvasive breast cancer and, despite treatment, a small fraction (5-10%) of DCIS patients develop subsequent invasive breast cancer (IBC). If not treated, at least 3 out of 4 women with DCIS will not develop IBC1-3. This implies many women with non-progressive, low-risk DCIS are likely to carry the burden of overtreatment. To solve this DCIS dilemma, two fundamental questions need to be answered. The first question is, how the subsequent IBC is related to the initial DCIS lesion. The seco

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Lee, Dhong Won, Dong Hwan Lee, Seung Ik Cho, et al. "Comparison of ACL and Anterolateral Ligament Reconstruction With Isolated ACL Reconstruction Using Hamstring Autograft: Outcomes in Young Female Patients With High-Grade Pivot Shift." Orthopaedic Journal of Sports Medicine 11, no. 9 (2023). http://dx.doi.org/10.1177/23259671231178048.

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Background: Inferior return to sports (RTS) and functional outcomes have been reported in women after anterior cruciate ligament reconstruction (ACLR). Purpose/Hypothesis: The purpose was to evaluate the results of combined ACLR and anterolateral ligament reconstruction (ALLR) in young women with a high-grade pivot shift (grade ≥2). It was hypothesized that combined ACLR and ALLR would result in better RTS and rotational stability than isolated ACLR. Study Design: Cohort study; Level of evidence, 3. Methods: Two groups were retrospectively evaluated and compared. Group I (n = 39; mean age, 31.

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Dalton, Liam, Blair Richards, and Marisa H. Miceli. "814. Impact of Testing Turnaround Times on Clinical Outcome in Hospitalized Patients with Histoplasmosis and Blastomycosis." Open Forum Infectious Diseases 10, Supplement_2 (2023). http://dx.doi.org/10.1093/ofid/ofad500.859.

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Abstract Background Patients (pt) with histoplasmosis (histo) and blastomycosis (blasto) requiring hospitalization have unacceptably high mortality rates. In part, this is due to a delay in diagnosis. Serum (S) and urine (U) antigen (Ag) testing are often crucial for timely antifungal therapy. Clinical observations suggested delays in ordering samples to be sent to reference labs upon admission and prolonged turnaround time (TAT) for test results can lead to delays in starting therapy and poor outcomes. We sought to determine the impact of TAT for histo and blasto Ag testing on clinical outcom

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Siraj, M. Ahsan, Robert Lao, Abdul Momen, Dorrin Zarrin Khat, and Mansoor Husain. "Abstract 4141421: Soluble adenylyl cyclase prevents cardiac rupture and adverse ventricular remodeling after myocardial infarction." Circulation 150, Suppl_1 (2024). http://dx.doi.org/10.1161/circ.150.suppl_1.4141421.

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Background: The ubiquitous second messenger cyclic adenosine monophosphate (cAMP) plays a key role in post-myocardial infarction [MI] remodeling, influencing apoptosis, inflammation, fibrosis and metabolism. Unlike transmembrane activators of cAMP, soluble adenylyl cyclase (sAC) represents a unique source of intracellular and mitochondrial cAMP, and metabolic sensor due to its ability to regulate oxidative metabolism and cell survival. However, a role for sAC in post-MI remodeling was not known. Methods and Results: Permanent LAD ligation was used to induce experimental MI in 10-12 wk old sAC

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Du, Mengxi, and Fang Fang Zhang. "Dietary Supplement Use Among Adult Cancer Survivors in the United States." FASEB Journal 31, S1 (2017). http://dx.doi.org/10.1096/fasebj.31.1_supplement.168.6.

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BackgroundMany cancer patients initiated supplement use after cancer diagnosis and yet the effect of supplement use on survival has not been established. The trend of and factors associated with dietary supplement use in cancer survivors warrant further investigation.MethodsWe examined the trend of dietary supplemental use in 1,902 adult cancer survivors who participated in the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2012, and compared the frequency of supplement use in cancer survivors to that of 3,804 individuals with no history of cancer who were matched to th

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Wilcox, Mark, Dave Heaton, Aruni Mulgirigama, et al. "P18 Treatment patterns and extent of inappropriate antimicrobial treatment among female patients with uncomplicated urinary tract infection in England." JAC-Antimicrobial Resistance 5, Supplement_3 (2023). http://dx.doi.org/10.1093/jacamr/dlad077.022.

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Abstract Background and Objectives Inappropriate antimicrobial treatment of uncomplicated urinary tract infection (uUTI) has potential impacts on healthcare resource use and costs. We characterized treatment patterns for uUTI in England, including the extent of inappropriate treatment. Methods This retrospective cohort study utilized anonymized patient data from the Clinical Practice Research Datalink (CPRD) database from 1 January 2018 to 31 December 2019. Female patients ≥12 years with a diagnosis of community-acquired uUTI (index), who had received ≥1 oral antibiotic within ±5 days of index

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Chung, P., O. Kocur, P. Xie, Z. Rosenwaks, and G. Palermo. "P-250 The exclusive role of sperm DNA fragmentation on the clinical outcome of a sibling donor oocyte cohort." Human Reproduction 38, Supplement_1 (2023). http://dx.doi.org/10.1093/humrep/dead093.608.

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Abstract Study question Can sperm chromatin fragmentation (SCF) overwhelm the oocyte repair mechanism of healthy, young oocytes and impair embryo development and clinical outcome? Summary answer Elevated SCF, with its double-stranded DNA (dsDNA) component, remarkably impairs clinical outcome, despite oocyte repair mechanisms present in a sibling donor oocyte cohort. What is known already Despite a normal semen analysis, approximately 10-20% of males of reproductive age still have a subtle infertility. Therefore, conventional semen analysis is insufficient to identify the specific issues relate

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Dolomatov, S.I., та W. Zukow. "Эпигенетика почек = Kidneys epigenetics". 7 липня 2019. https://doi.org/10.5281/zenodo.3270754.

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<strong>Dolomatov S.I., Zukow W. </strong><strong>Эпигенетика почек</strong><strong> = Kidney</strong><strong>s</strong><strong> epigenetics</strong><strong>. </strong><strong>RSW. Radom,</strong><strong> 144 </strong><strong>p. ISBN </strong><strong>9780359774524</strong><strong>.</strong><strong> DOI </strong><strong>http://dx.doi.org/10.5281/zenodo.3270699</strong><strong> PBN Poland </strong><strong>https://pbn.nauka.gov.pl/sedno-webapp/works/917606</strong>           <strong>Radomska Szkoła Wyższa w Radomiu, Radom, Poland</strong>         &nbsp

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