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1

Lokhandwala, S., T. Allard, T. Riggins, and R. M. Spencer. "0334 Hippocampal Development, Slow Wave Activity, and Nap-Dependent Memory Consolidation in Early Childhood." Sleep 43, Supplement_1 (2020): A127. http://dx.doi.org/10.1093/sleep/zsaa056.331.

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Abstract Introduction Naps support memory consolidation in early childhood. In adults, nap-dependent declarative consolidation is associated with SWA. SWA increases from early childhood into adulthood, and the shift of SWA from occipital to frontal distribution (F/O-ratio) is a marker of brain maturation. Thus, we explored how electrophysiological and structural characteristics of brain development relate to nap-dependent declarative learning in early childhood. Methods Twelve preschool-age children (8 female, M=48 months, SD=0.44) have completed three sessions (~1wk apart) within a larger stu
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Gore, C., D. Hill, and S. Lee. "C-57 Prematurity and Perinatal Insult: Examining the relationships between parent and teacher ratings of executive functioning and academic readiness." Archives of Clinical Neuropsychology 34, no. 6 (2019): 1086. http://dx.doi.org/10.1093/arclin/acz034.219.

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Abstract Objective Extremely preterm children and those with a history of perinatal insult (e.g., hemorrhage, hypoxic-ischemic injury) show higher rates of cognitive and academic problems, including executive functioning (EF). EF becomes increasingly important in elementary school as curriculum demands increase. The current study examines the relationship between parent- and teacher-reported EF and early academic performance in this population at school-age. Method This study reviewed retrospective neuropsychological evaluations in a sample of 135 patients (ages 3:9-10:5 years, M = 5.8) from a
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Wu, Lin, Liming Cao, Likun Chen, et al. "Molecular characterization of NSCLC-like and SCLC-like subsets in Chinese pulmonary large cell neuroendocrine carcinoma (LCNEC)." Journal of Clinical Oncology 37, no. 15_suppl (2019): e13125-e13125. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e13125.

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e13125 Background: LCNEC is an aggressive, biologically heterogenous carcinoma which can be molecularly characterized as SCLC-like and NSCLC-like. Accurate distinction of molecular subset is of major clinical relevance since it may guide treatment choices in LCNEC. Here we determined the genomic characteristics of the two LCNEC subsets in a Chinese cohort to clarify their correlations with traditional lung cancer histologies. Methods: FFPE samples from 31 LCNECs were sequenced using a 520-cancer-related gene panel, with an average sequencing depth of 1353X. Comparative mutational analysis was
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Moerbeck, Leonardo, Ricardo Parreira, Gonçalo Seixas, Rita Velez, Ana Domingos, and Sandra Antunes. "Update on tick-borne rickettsioses in mainland Portugal: emerging threats and potential vectors." Parasites & Vectors 17, no. 1 (2024): 1–11. https://doi.org/10.1186/s13071-024-06627-5.

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Moerbeck, Leonardo, Parreira, Ricardo, Seixas, Gonçalo, Velez, Rita, Domingos, Ana, Antunes, Sandra (2024): Update on tick-borne rickettsioses in mainland Portugal: emerging threats and potential vectors. Parasites & Vectors (538) 17 (1): 1-11, DOI: 10.1186/s13071-024-06627-5, URL: https://doi.org/10.1186/s13071-024-06627-5
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5

Hosokawa, Kohei, Jong Wook Lee, Jun Ho Jang, et al. "Long-Term Follow-up of Patients with Aplastic Anemia Enrolled in Phase 2/3 Trials of Immunosuppressive Therapy Plus Romiplostim As a First-Line Treatment: Two-Year Interim Analysis." Blood 144, Supplement 1 (2024): 1310. https://doi.org/10.1182/blood-2024-193925.

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Background Phase 2/3 clinical trials evaluating the safety and efficacy of immunosuppressive therapy (IST) plus romiplostim in IST-naïve patients with aplastic anemia (AA) have been previously reported (531-003 trial [rabbit ATG+CsA+romiplostim; NCT03957694] and 531-004 trial [CsA+romiplostim; NCT04095936]). The long-term data on efficacy outcomes and safety profiles are lacking after completion of 27 or 53 weeks romiplostim treatment. As the collection of data on long-term treatment outcomes and disease monitoring is essential owing to the chronic life-threatening nature of the disease, we co
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6

Metzger, R., C. G. Leichman, K. D. Danenberg, et al. "ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy." Journal of Clinical Oncology 16, no. 1 (1998): 309–16. http://dx.doi.org/10.1200/jco.1998.16.1.309.

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PURPOSE We have previously shown that relative thymidylate synthase (TS) mRNA levels in primary gastric adenocarcinomas treated with fluorouracil (5-FU) and cisplatin are inversely associated with response and survival. This is a presumed function of TS as a target for 5-FU activity. We now test the hypotheses that the relative mRNA level of the excision repair cross-complementing (ERCC1) gene is inversely associated with response and survival as an independent function of cisplatin efficacy. PATIENTS AND METHODS Patients had intact, untreated, primary gastric adenocarcinoma cancer and were ev
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Shin, S., H. Jeung, J. Ahn, et al. "Mobilized circulating endothelial progenitor cells after the first cycle of chemotherapy with prophylactic G-CSF can be used as a predictive biomarker and patient selection marker for anti-angiogenesis combination treatment." Journal of Clinical Oncology 25, no. 18_suppl (2007): 4638. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.4638.

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4638 Background: We investigated whether the level of circulating endothelial progenitor cells (CEPs) and endothelial cells (CECs) could be used as surrogate predictors of clinical outcome in patients receiving taxotere-based chemotherapy for advanced gastric cancer. Methods: Peripheral blood mononuclear cells were obtained in 49 gastric cancer patients who received taxotere combined with 5-FU and leucovorine (FLT regimen) after chemotherapy and prophylactic G-CSF treatment. To categorize the endothelial cells, immunofluorescent staining for specific endothelial cell markers (CD34, vWF, P1H12,
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Davis, L. E., A. R. Hohimer, G. D. Giraud, M. S. Paul, and M. J. Morton. "Vascular pressure-volume relationships in pregnant and estrogen-treated guinea pigs." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 257, no. 5 (1989): R1205—R1211. http://dx.doi.org/10.1152/ajpregu.1989.257.5.r1205.

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We investigated the relationship between mean circulatory filling pressure (MCFP) and blood volume in nonpregnant (NP), estrogen-treated (E), and pregnant (P) guinea pigs. Reversible circulatory arrest was produced by rapid ventricular pacing or acetylcholine in unanesthetized animals remote from surgery. MCFP (mmHg) was higher for E (7.1 +/- 0.3) than for NP (5.8 +/- 0.5) or P (5.3 +/- 0.4). The gradient for venous return, the difference between MCFP and right atrial pressure (mmHg), did not differ in NP- (6.0 +/- 0.5), P- (5.8 +/- 0.5), or E- (5.8 +/- 0.4) treated animals. Capacitance, the b
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9

Chung, Dong Seok, C. W. Jea, Jae Hong Yoon, and J. K. Kim. "Effect of Mn Addition on the Mechanical Properties in Al-Cu-Li-Mg-Ag-Zr Alloys." Materials Science Forum 539-543 (March 2007): 481–86. http://dx.doi.org/10.4028/www.scientific.net/msf.539-543.481.

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The mechanical properties of Al–5%Cu–1.3%Li–0.4%Mg–0.4%Ag–1.16%Zr alloys without Mn and with 0.3%, 0.6% and 1.2% Mn have been investigated after the aging at the temperatures of 90, 150, 180, and 230 oC. With Mn addition the alloys show a good work-hardening property, and the elongation of alloys increases. With the 0.6% Mn the best elongation can be obtained. The strength of alloys with 0.3% or 1.2% Mn is lower than that of the alloy without Mn, whereas the strength of alloy with 0.6% Mn is almost same as that of the alloy without Mn. In the alloy with 0.6% Mn aged at 180 oC for 12 hours the
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Puchulu, Félix. "Por el no." Revista de la Sociedad Argentina de Diabetes 56, no. 3Sup (2022): 40. http://dx.doi.org/10.47196/diab.v56i3sup.532.

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El agregado de metformina en pacientes adultos con diabetes mellitus tipo 1 (DM1) favoreció pequeños descensos de peso y de los niveles lipídicos, pero no ha mejorado la HbA1c.
 Los estudios de ARGLP-1 en DM1 se desarrollaron con liraglutida y demostraron modestas reducciones de la HbA1c (0,3-0,4%), descenso de peso (5 kg) y reducción de la dosis de insulina (10-12%). Como efectos adversos, también se observó mayor presentación de náuseas y vómitos, con el riesgo que supone en un paciente insulinotratado. La tasa de hipoglucemia sintomática aumentó con liraglutida 1,8 mg y 1,2 mg vs place
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Moore, Andrew, Benjamin R. Smith, Ryan J. O'Leary, Caroline P. Hoch, Christopher E. Gross, and Daniel J. Scott. "TranexAMIC Acid Associated with Less Wound Complications in Hindfoot Surgery." Foot & Ankle Orthopaedics 7, no. 1 (2022): 2473011421S0005. http://dx.doi.org/10.1177/2473011421s00050.

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Category: Hindfoot; Ankle Introduction/Purpose: Tranexamic acid (TXA) is an increasingly popular antifibrinolytic therapy used to decrease bleeding during surgery and postoperative swelling. TXA has been shown to decrease bleeding in total knee arthroplasty and total hip arthroplasty, and is now routinely administered in many centers performing these operations. To date, there is very limited data on its use in foot and ankle surgery. We sought to review of the effect of TXA on outcomes of total ankle arthroplasty (TAA), hindfoot fusions, and other related hindfoot surgeries, with the hypothes
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12

Liu, Yilin, Jiali Huo, Meili Ge, et al. "Predictive value of thyroid function in severe aplastic anemia patients treated with immunosuppressive therapy." Blood Science 6, no. 2 (2024): e00182. http://dx.doi.org/10.1097/bs9.0000000000000182.

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To explore the predictive value of thyroid function in severe aplastic anemia (SAA) patients treated with immunosuppressive therapy (IST), 149 SAA patients in our center were enrolled between February 2015 and June 2020 in this study. We assessed the thyroid function of 134 patients without primary thyroid diseases, and discovered that 89 patients were accompanied by abnormal thyroid hormone, especially low triiodothyronine (T3). Patients with higher pretreatment-free T3 (FT3) levels (>5 pmol/L) demonstrated superior response rates at 3 and 6 months after IST compared to those with lower FT
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Bunick, Christopher, Raj Chovatiya, Emma Guttman, et al. "533 - Long-term 5-year safety of upadacitinib in moderate-to-severe atopic dermatitis: an integrated analysis including over 7000 patient-years of exposure." British Journal of Dermatology 190, Supplement_2 (2024): ii35—ii36. http://dx.doi.org/10.1093/bjd/ljad498.037.

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Abstract Introduction/Background Atopic dermatitis (AD) is a chronic, relapsing, inflammatory skin disease characterized by intense itch and eczematous skin lesions, impacting individuals at any age. There is a need for AD treatments that provide rapid itch relief and skin clearance that are safe for long-term use. Upadacitinib is a selective, reversible oral Janus kinase 1 (JAK1) inhibitor approved in multiple countries for the treatment of moderate-to-severe AD in adults and adolescents. Objectives We evaluated the long-term safety for up to 5 years of upadacitinib 15 mg and 30 mg use in ado
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14

Burns, Ryan D., Timothy A. Brusseau, and James C. Hannon. "Effect of Comprehensive School Physical Activity Programming on Cardiometabolic Health Markers in Children From Low-Income Schools." Journal of Physical Activity and Health 14, no. 9 (2017): 671–76. http://dx.doi.org/10.1123/jpah.2016-0691.

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Background:The purpose of this study was to examine the effect of a 36-week Comprehensive School Physical Activity Program (CSPAP) on cardiometabolic health markers in children from low-income schools.Methods:Participants were 217 school-aged children (mean age = 10.1 ± 1.1 years; 114 girls, 103 boys) recruited from 5 low-income elementary schools. Cardiometabolic health markers were collected in a fasted state at 2 time-points, before commencement of the CSPAP for classroom and school level clustering and the modifying effects of grade level and sex, there were statistically significant impro
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15

Marcucci, Guido, C. D. Baldus, A. S. Ruppert, et al. "Overexpression of the ERG Gene Is an Adverse Prognostic Factor in Acute Myeloid Leukemia (AML) with Normal Cytogenetics (NC): A Cancer and Leukemia Group B Study (CALGB)." Blood 106, no. 11 (2005): 335. http://dx.doi.org/10.1182/blood.v106.11.335.335.

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Abstract Around 45% of adults with AML have NC and are included in an intermediate-risk group. However, their 5-year (yr) overall survival (OS) rates vary between 24 and 42%, likely due to the prognostic impact of submicroscopic genetic alterations, e.g., mutations in FLT3, CEBPA, MLL and NPM genes and overexpression of BAALC. We recently showed that ERG, an ETS-Related Gene mapped to 21q22, is often overexpressed in AML with unfavorable complex karyotypes, and in a subset of NC AML (PNAS2004;101:3915), suggesting that ERG overexpression contributes to an aggressive phenotype in AML. Here we a
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Glew, David N. "Aqueous nonelectrolyte solutions. Part XIX. Congruent dissociation melting point and the formula of structure II methane hydrate." Canadian Journal of Chemistry 81, no. 2 (2003): 179–85. http://dx.doi.org/10.1139/v03-004.

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Twenty-four equilibrium pressures, P(h2l1g), of structure II methane hydrate h2 with water l1 between 27.0 and 46.9°C are well represented by a four-parameter equation, which indicates a standard error (SE) of 1.95% on a single pressure measurement. Forty equilibrium constants Kp(h2[Formula: see text]l1g) for dissociation of structure II methane hydrate into water and methane between 27.0 and 47.7°C and at pressures up to 784 MPa at 45.0°C are best represented by a three-parameter thermodynamic equation, which indicates an SE 1.25% on a single Kp(h2[Formula: see text]l1g) determination. The co
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Odeny, Thomas A., Nicole Farha, Wilfred Vazquez, et al. "Association between primary tumor site, perioperative CEA ratio, and overall survival in patients with colorectal cancer." Journal of Clinical Oncology 37, no. 4_suppl (2019): 518. http://dx.doi.org/10.1200/jco.2019.37.4_suppl.518.

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518 Background: There are differences in the incidence, clinical presentation, molecular pathogenesis and outcome of colorectal cancer (CRC) based on the tumor location. Emerging research suggests that the perioperative carcinoembryonic antigen (CEA) ratio is a prognostic factor for CRC patients. We aimed to determine the association between tumor location, perioperative CEA ratio, and 5-year survival among patients with CRC. Methods: We analyzed 111 patients who underwent resection for CRC at KUMC. After excluding patients without pre- or post-operative CEA data, 62 patients for whom we could
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18

Tsai, Ming-Horng, Shih-Ming Chu, Reyin Lien, et al. "Complications Associated with 2 Different Types of Percutaneously Inserted Central Venous Catheters in Very Low Birth Weight Infants." Infection Control & Hospital Epidemiology 32, no. 3 (2011): 258–66. http://dx.doi.org/10.1086/658335.

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Objective.To identify the prevalence and risk factors for complications associated with percutaneously inserted central venous catheters (PICCs) and evaluate the effect of different catheter types and their indwelling time on catheter-related complications.Design.Retrospective cohort study.Setting.A 49-bed neonatal intensive-care teaching hospital in Taiwan.Patients.Between 2004 and 2007, 518 single-lumen PICCs (defined as “old type”) and 290 PICCs with a stiffening stylet and a thicker introducer (“new type”) were inserted in a total of 534 neonates with a birth body weight of 1,500 g or less
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Chen, Jiao, Juan Wang, Zhongwen Wang, Mei Huang, Meixiang Luo, and Yanyu Cai. "Application and effectiveness study of tripartite linkage nursing in prediabetes type 2 diabetes: A retrospective study." Medicine 104, no. 19 (2025): e42138. https://doi.org/10.1097/md.0000000000042138.

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This study aimed to evaluate the tripartite linkage nursing model’s effectiveness in prediabetic patients at risk of type 2 diabetes mellitus, assessing its impact on glycemic control, metabolic outcomes, diabetes prevention, and treatment adherence. In this retrospective cohort study, 400 patients (2020–2022) were allocated via medical record review to control (standard care) and experimental groups (tripartite model integrating hospital-community-home management). Clinical parameters (fasting plasma glucose, 2-hour postprandial glucose, glycated hemoglobin, body mass index, lipid profiles, b
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20

Bardis, Costas N., Stavros A. Kavouras, Giannis Arnaoutis, Demosthenes B. Panagiotakos, and Labros S. Sidossis. "Mild Dehydration and Cycling Performance During 5-Kilometer Hill Climbing." Journal of Athletic Training 48, no. 6 (2013): 741–47. http://dx.doi.org/10.4085/1062-6050-48.5.01.

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Context: Hydration has been shown to be an important factor in performance; however, the effects of mild dehydration during intense cycling are not clear. Objective: To determine the influence of mild dehydration on cycling performance during an outdoor climbing trial in the heat (ambient temperature = 29.0°C ± 2.2°C). Design: Crossover study. Setting: Outdoor. Patients or Other Participants: Ten well-trained, male endurance cyclists (age = 28 ± 5 years, height = 182 ± 0.4 cm, mass = 73 ± 4 kg, maximal oxygen uptake = 56 ± 9 mL·min−1·kg−1, body fat = 23% ± 2%, maximal power = 354 ± 48 W). Inte
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21

Wang, A., Y. Ding, and H. Cao. "DOP026 Porphyromonas gingivalis secreted htpG disrupts TLR4/ PAPSS2-mediated mucin sulfation and aggravates ulcerative colitis." Journal of Crohn's and Colitis 19, Supplement_1 (2025): i132. https://doi.org/10.1093/ecco-jcc/jjae190.0065.

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Abstract Background The role of the oral microbiota in the development of IBD and its association with disease severity has been established. However, the specific impact and mechanism of Porphyromonas gingivalis (P.g), a major pathogenic bacteria in the oral cavity, in exacerbating colitis remain unclear. Our objective is to investigate how P.g exacerbates ulcerative colitis. Methods Fecal samples were collected from patients with active ulcerative colitis and compared to those from healthy controls to assess the abundance of P.g. The impact of P.g on colitis and the colonic mucosal barrier w
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22

Onder, Arif Hakan, Aysegul Seremet Keskin, Kubra Demir Onder, Filiz Kizilates, and Cihan Heybeli. "Factors associated with development of an acute ischemic event during hospitalization for COVID-19 in cancer and non-cancer patients." Annals of Saudi Medicine 43, no. 1 (2023): 1–9. http://dx.doi.org/10.5144/0256-4947.2023.1.

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BACKGROUND: COVID-19 and solid cancer are both associated with an increased risk of thromboembolism. OBJECTIVES: Assess whether solid cancer is a risk factor for acute ischemic event development among patients with COVID-19. DESIGN: Retrospective cohort SETTING: A tertiary training and research hospital PATIENTS AND METHODS: Patients who were hospitalized for COVID-19 for ≥3 days between 15 March 2020 and 30 March 2021 at Antalya Training and Research Hospital, Antalya, Turkiye. were included in the study. Independent predictors of the development of acute ischemic events during hospitalizatio
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Gopal, Ajay K., Theodore A. Gooley, David G. Maloney, et al. "High-dose radioimmunotherapy versus conventional high-dose therapy and autologous hematopoietic stem cell transplantation for relapsed follicular non-Hodgkin lymphoma: a multivariable cohort analysis." Blood 102, no. 7 (2003): 2351–57. http://dx.doi.org/10.1182/blood-2003-02-0622.

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Abstract We performed a multivariable comparison of 125 consecutive patients with follicular lymphoma (FL) treated at our centers with either high-dose radioimmunotherapy (HD-RIT) using 131I-anti-CD20 (n = 27) or conventional high-dose therapy (C-HDT) (n = 98) and autologous hematopoietic stem cell transplantation. The groups were similar, although more patients treated with HD-RIT had an elevated pretransplantation level of lactate dehydrogenase (41% versus 20%, P = .03) and elevated international prognostic score (41% versus 19%, P = .02). Patients treated with HD-RIT received individualized
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24

Facharztmagazine, Redaktion. "Scheidenflora aufbauen mit Probiotikum." gynäkologie + geburtshilfe 28, no. 5 (2023): 65. http://dx.doi.org/10.1007/s15013-023-5308-5.

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Greiff, Martin Sebastian. "Verbliebener Tupfer nach Versorgung eines Dammrisses." gynäkologie + geburtshilfe 28, no. 2 (2023): 66. http://dx.doi.org/10.1007/s15013-023-5138-5.

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26

Taner, Hasan Ali, and Vildan Onen. "Evaluation of the effect of the main parameters on chalcopyrite flotation in the presence of kaolinite and montmorillonite." Journal of Central South University 30, no. 7 (2023): 2217–33. http://dx.doi.org/10.1007/s11771-023-5386-5.

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Zhang, Du-chao, Ting-ying Li, Hao Wang, Lin Chen, Yong-mi Wang та Xiao-yun Jia. "氧化焙烧-循环浸出-沉淀法脱除废旧锂离子电池粉末中杂质元素". Journal of Central South University 30, № 7 (2023): 2205–16. http://dx.doi.org/10.1007/s11771-023-5378-5.

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Facharztmagazine, Redaktion. "Immunprophylaxe bei rezidivierenden Scheideninfektionen." gynäkologie + geburtshilfe 28, no. 6 (2023): 60. http://dx.doi.org/10.1007/s15013-023-5385-5.

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Agarkov, N. M., O. I. Okhotnikov, S. I. Korneeva, et al. "Pleiotropic effect of chronotherapy with a fixed combination of amlodipine, lisinopril and rosuvastatin on the psychological state in elderly hypertensive patients with metabolic syndrome." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 27, no. 5 (2021): 536–45. http://dx.doi.org/10.18705/1607-419x-2021-27-5-536-545.

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Background. Hypertension (HTN) in metabolic syndrome (MS) in the elderly contributes to the formation of cognitive disorders and anxiety-depressive disorders. Objective. To study the psychological state of elderly patients with HTN and MS treated by evening versus morning dosing of a fixed combination (FC) of amlodipine, lisinopril and rosuvastatin. Design and methods. In a randomized, double-blind, controlled trial 63 patients aged 60–74 years with HTN and MS received a FC of amlodipine, liiznopril and rosuvastatin at a dose of 5/10/10 mg in the evening (after 20:00 hours) (study group) And 5
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Tefera, Getamesay, and Prof Xinhai Lu. "Empirical Analysis on Local Farmers Perceptions towards Overseas Farmland Investments in Ethiopia." Applied Science and Innovative Research 3, no. 1 (2019): 1. http://dx.doi.org/10.22158/asir.v3n1p1.

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<em>In the past few decades there has been growing interest among multinational companies towards investment in overseas farmland. The whole process and result of such investments has become a hot topic of debate among scholars, media experts, social activists, and policy practitioners. The huge wave of overseas large scale farm land investment has generated conflicting views among scholars and developmental policy practitioners regarding its significance. Ethiopia has been in the spotlight in this regard as the government was avowed to attract investment in farmland and, in return, many
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Rossi, Davide, Silvia Rasi, Silvia Franceschetti, et al. "The Pharmacogenetic Background of the Host Is An Independent Predictor of Outcome and Toxicity in Diffuse Large B Cell Lymphoma Treated with R-CHOP21." Blood 112, no. 11 (2008): 480. http://dx.doi.org/10.1182/blood.v112.11.480.480.

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Abstract Scant information is available on the impact of the host genetic background as a predictor of outcome and toxicity in diffuse large B cell lymphoma (DLBCL) treated with R-CHOP. We verified whether relevant single nucleotide polymorphisms (SNPs) of the host may further refine prognostic stratification and toxicity prediction in DLBCL treated with R-CHOP21. The study was based on 106 consecutive DLBCL provided with a prospectively collected dataset. Candidate SNPs belonged to genes known to be involved in the pharmacogenetics of cyclophosphamide, doxorubicin, vincristine, prednisone and
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Shishkin, V., G. V. Kudriavtseva, Y. Malenkov, and V. V. Shishkin. "THU0238 ASSOCIATION OF SYSTEMIC DISEASES OF CONNECTIVE TISSUE (SDCT) AND GERONTOLOGICAL PROCESSES." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 346.1–346. http://dx.doi.org/10.1136/annrheumdis-2020-eular.1154.

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Background:The approach from the point of view of the evolutionary perspective of finding targets for therapeutic effects among the components of the cellular destruction system is critical both in the treatment of rheumatological diseases and in gerontology.Objectives:To identify the relationships between the pathways of cell death in synovial fluid (SF) of people of different age groups with SDCT.Methods:SF was analyzed in patients of two age groups. Group N 1 of patients: 10 SLE (43±2.3 years), 13 RA (45±1.6 years), 7 SSD (35±1.8 years) and 8 donors (42±2.7 years, postmortem). Group N 2 (ag
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Jianfei, Jeff, Wenmin Du, Laura Chu, Xiaopei Wang, and Jane Pruemer. "Health care utilization and treatment patterns for patients (pts) with gastric cancer (GC) in China." Journal of Clinical Oncology 31, no. 15_suppl (2013): e15185-e15185. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.e15185.

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e15185 Background: GC is the third most common cancer in China with ~0.3 million deaths and 0.4 million new cases annually. Objective: To describe treatment patterns and survival for pts with GC, and to assess treatment outcomes and associated factors including health insurance coverage, gastric-intestinal disease, clinical comorbidities and family genetic or demographic factors. Methods: A retrospective cohort study was conducted. Primary data sources were medical records collected from multiple major Shanghai medical centers with timeframe of Jan2004 - Mar2010. Treatment outcomes included ‘i
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Gabriels, L., P. Cosyns, and B. Nuttin. "Differential Impact of Deep Brain Stimulation or Anterior Capsulotomy on General Functioning, Personality Features and Quality of Life in OCD." European Psychiatry 26, S2 (2011): 1140. http://dx.doi.org/10.1016/s0924-9338(11)72845-0.

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IntroductionResearch on deep brain stimulation (DBS) for treatment refractory obsessive-compulsive disorder (OCD) shows promising effects on symptoms severity.ObjectivesTo compare outcomes between DBS and bilateral capsulotomy on general functioning, personality traits and quality of life.MethodsConsecutive patients with severe and treatment refractory OCD underwent DBS in the anterior limb of the internal capsule (DBS; n = 14) or anterior capsulotomy (CAPS; n = 14). They were tested before surgery (baseline-BL) and after a mean follow-up time (FU) of 19 months (range 14-31 months). Changes in
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Williams, Nakisha D., Arda Durmaz, Carlos Bravo-Perez, et al. "Association Vs Causation: Epidemiologic Clues As to the Autoimmune Pathogenesis of MDS." Blood 142, Supplement 1 (2023): 4066. http://dx.doi.org/10.1182/blood-2023-181916.

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Multiple clinical associations of MDS and autoimmunity have been described, but the pathogenesis and cause-effect relationship are likely diverse and possibly intertwining. Telomeropathies, while increasing risk of bone marrow failure, can be also associated with liver or lung fibrosis and therapies for Wegener's granulomatosis can predispose to MDS. Moreover, clonal hematopoiesis (CH) seems to be more prevalent in some autoimmune diseases 1 (AD) perpetuating a process that may ultimately lead to increased risk of MDS. Reverse scenarios are also possible and AD can be a result of MDS as a form
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Gershenson, David M., Anna M. Miller, Victoria L. Champion, et al. "Reproductive and Sexual Function After Platinum-Based Chemotherapy in Long-Term Ovarian Germ Cell Tumor Survivors: A Gynecologic Oncology Group Study." Journal of Clinical Oncology 25, no. 19 (2007): 2792–97. http://dx.doi.org/10.1200/jco.2006.08.4590.

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Purpose To compare malignant ovarian germ cell tumor survivors with a matched control group of females on menstrual and reproductive outcomes, sexual functioning, and dyadic adjustment. Patients and Methods Eligible patients met the following criteria: (1) history of malignant ovarian germ cell tumor; (2) treatment with surgery plus platinum-based chemotherapy; (3) age at least 18 years and continuously disease-free with minimum follow-up of 2 years; (4) capability of completing questionnaire and telephone interview; and (5) completion of written informed consent. The control group was drawn f
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Dighade, N. R., M. D. Shende, and A. V. Kasture. "DEVELOPMENT OF HPTLC METHOD FOR SIMULTANEOUS ESTIMATION OF OFLOXACIN AND ORNIDAZOLE IN COMBINED DOSAGE FORM." INDIAN DRUGS 51, no. 04 (2014): 20–25. http://dx.doi.org/10.53879/id.51.04.p0020.

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A simple and accurate high performance thin layer chromatographic (HPLTC) method have been developed and validated as per ICH guidelines for estimation of Ofloxacin (OFL) and Ornidazole (ORN) in combined dosage form. The mobile phase was acetone : water : toluene : triethylamine (5.8:1.5:2:1.6 V/V) was found to be best which gave high resolution with Rf 0.25 and 0.82 for ofloxacin and ornidazole respectively. The linearity of ofloxacin and ornidazole was found to be in the range of 0.2 to 0.3 µg/mL and 0.4 to 0.8 µg/mL respectively. The coefficient of correlation (r2 ) was found to be greater
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Kozak, Jolanta, and Maria Włodarczyk-Makuła. "The Use of Sodium Percarbonate in the Fenton Reaction for the PAHs Oxidation." Civil and Environmental Engineering Reports 28, no. 2 (2018): 124–39. http://dx.doi.org/10.2478/ceer-2018-0024.

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Abstract The aim of the paper was to determine the effectiveness of the removal of 4, 5and 6 - ring PAHs from coking wastewater using sodium percarbonate Na2CO3∙1,5 H2O2 and iron sulphate in acid condition. The samples were exposing to ultraviolet rays. The source of UV-C radiation was a lamp emitting a wave of light with a length of λ = 264 nm, placed directly above the layer of the samples wastewater. The sodium percarbonate Na2CO3 1.5 H2O2 doses were determined on the basis of stoichiometric calculation. Ratio of iron ions to the hydrogen peroxide released in reaction was: 0.5; 0.4; 0.3; 0.
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Mohr, Magni, Jens Jung Nielsen, and Jens Bangsbo. "Caffeine intake improves intense intermittent exercise performance and reduces muscle interstitial potassium accumulation." Journal of Applied Physiology 111, no. 5 (2011): 1372–79. http://dx.doi.org/10.1152/japplphysiol.01028.2010.

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The effect of oral caffeine ingestion on intense intermittent exercise performance and muscle interstitial ion concentrations was examined. The study consists of two studies (S1 and S2). In S1, 12 subjects completed the Yo-Yo intermittent recovery level 2 (Yo-Yo IR2) test with prior caffeine (6 mg/kg body wt; CAF) or placebo (PLA) intake. In S2, 6 subjects performed one low-intensity (20 W) and three intense (50 W) 3-min (separated by 5 min) one-legged knee-extension exercise bouts with (CAF) and without (CON) prior caffeine supplementation for determination of muscle interstitial K+ and Na+ w
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Eggeling, Lena, Stefan Breer, Tobias Claus Drenck, Karl-Heinz Frosch, and Ralph Akoto. "Double-Layered Quadriceps Tendon Autografts Provide Lower Failure Rates and Improved Clinical Results Compared With Hamstring Tendon Grafts in Revision ACL Reconstruction." Orthopaedic Journal of Sports Medicine 9, no. 12 (2021): 232596712110469. http://dx.doi.org/10.1177/23259671211046929.

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Background: We developed a quadriceps-tendon graft technique using a double-layered, partial-thickness, soft tissue quadriceps tendon graft (dlQUAD) for anterior cruciate ligament reconstruction (ACLR). This technique allows simple femoral loop button fixation and a limited harvest depth of the quadriceps tendon. Purpose: To evaluate the outcome of patients undergoing revision ACLR using the dlQUAD technique compared with a hamstring tendon graft (HT). Study Design: Cohort study; Level of evidence, 3. Methods: A total of 114 patients who underwent revision ACLR between 2017 and 2018 were inclu
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Fanelli, Vito, Yasumasa Morita, Paola Cappello та ін. "Neuromuscular Blocking Agent Cisatracurium Attenuates Lung Injury by Inhibition of Nicotinic Acetylcholine Receptor-α1". Anesthesiology 124, № 1 (2016): 132–40. http://dx.doi.org/10.1097/aln.0000000000000907.

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Abstract Background Neuromuscular blocking agents (NMBAs) bind the nicotinic acetylcholine receptor α1 (nAChRα1) that also contributes to inflammatory signaling. Thus, the author hypothesized that the use of NMBA mitigates lung injury by improving ventilator synchrony and decreasing inflammatory responses. Methods Lung injury was induced by intratracheal instillation of hydrogen chloride in rats that were randomized to receive no NMBA with evidence of asynchronous ventilation (noNMBA/aSYNC, n = 10); no NMBA with synchronous ventilation (noNMBA/SYNC, n = 10); cisatracurium (CIS, n = 10); or pan
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Marincowitz, Carl, Omar Bouamra, Tim Coates, et al. "1427 The effect of the COVID-19 pandemic on major trauma presentations and patient outcomes in English hospitals." Emergency Medicine Journal 39, no. 12 (2022): A960.2—A964. http://dx.doi.org/10.1136/emermed-2022-rcem2.2.

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Aims, Objectives and BackgroundThere is evidence that COVID-19 ‘lockdowns’ may have contributed to increased non-accidental injury, domestic violence and self-harm related to deteriorating mental health. Internationally, there is also evidence that the diversion of health care resources may led to worse outcomes for patients presenting with major trauma. There has been no previous national evaluation of ‘lockdown’ measures impact on the characteristics, treatment pathways and outcomes of trauma patients in EnglandWe aimed to assess the impact of successive lockdowns on the volume, demographics
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Alshehri, Mohammed, Weal Alshehri, Abdullah Alsubaie, et al. "Evaluating poor sleep quality and its risk factors in non-dialysis chronic kidney disease patients from Saudi Arabia." Medicine 104, no. 28 (2025): e43206. https://doi.org/10.1097/md.0000000000043206.

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This study aimed to assess sleep quality in patients with chronic kidney disease (CKD) in the Aseer Region of Saudi Arabia. This cross-sectional study focused on non-dialysis patients who attended CKD clinics. We used the validated Arabic version of the Pittsburgh Sleep Quality Index scoring questionnaire, which involves 7 component scores, each rated on a scale of 0 to 3. These component scores were aggregated to calculate a global score that ranged from 0 to 21. A global score >5 indicated poor sleep quality. The mean participants’ age was 53.8 ± 17.9 years, 66.5% were male, 93.5% were Sa
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Schnell-Inderst, P., D. Noßke, M. Weiss, et al. "Aquisition of age- and sex-dependent patient data for the calculation of annual radiation exposure in nuclear medicine: a German pilot study." Nuklearmedizin 43, no. 02 (2004): 45–56. http://dx.doi.org/10.1055/s-0038-1625591.

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Summary Aim: A pilote study for estimation of radiation exposure due to diagnostic procedures in nuclear medicine using routine data of hospitals and practices in Germany. Methods: Hospitals and practices willing to participate in the study supplied data of one year (1997), containing information on patients´ identification number, age, sex, type of diagnostic procedure, radiopharmaceutical, administered activity, type of health insurance (private/ public), inpatient/outpatient status, and so-called Leistungsziffer, which describes the type of medical performances in Germany. The effective dos
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Cheng, Xin-Meng, Tao Yang, Yan Zi, et al. "ST266 inhibits neointimal hyperplasia after arterial balloon injury in rats." Kardiologiia 63, no. 5 (2023): 53–61. http://dx.doi.org/10.18087/cardio.2023.5.n2257.

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Objective To examine the effect of Human Amnion-Derived Multipotent Progenitor (AMP) cells and their novel ST266 secretome on neointimal hyperplasia after arterial balloon injury in rats.Material and Methods Sprague-Dawley male rats were randomly divided into four groups (n=7): Control (PBS) group, systemic ST266 group, systemic AMP group and local AMP implant group. Neointimal hyperplasia was induced in the iliac using a 2F Fogarty embolectomy catheter. After surgery, the rats in the ST266 group were treated with 0.1, 0.5, or 1ml ST266 iv daily. In the systemic AMP groups, a single dose (SD)
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Ganz, Patricia A., Reena S. Cecchini, Julia R. White, et al. "Patient-reported outcomes (PROs) in NRG oncology/NSABP B-39/RTOG 0413: A randomized phase III study of conventional whole breast irradiation (WBI) versus partial breast irradiation (PBI) in stage 0, I, or II breast cancer." Journal of Clinical Oncology 37, no. 15_suppl (2019): 508. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.508.

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508 Background: PBI is an alternative to WBI, with potentially greater therapy (tx) compliance, and better integration with chemotherapy (CTX). NSABP B-39/RTOG 0413 clinical outcome results from 2018 did not show equivalence of PBI to WBI in local tumor control; PBI was statistically inferior, but with clinically small differences. PBI may be an acceptable alternative to WBI for some women. Understanding cosmesis and quality of life (QOL) treatment outcomes is important. Methods: B-39/0413 included a prospective QOL substudy with PRO evaluation of breast cancer treatment outcomes (cosmesis, fu
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Franson, K. L., J. Burggraaf, E. A. Bouman-Trio, et al. "A Phase I, Single and Fractionated, Ascending Dose Study Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of an Erythropoietic Mimetic Antibody Fusion Protein, CNTO528, in Healthy Male Subjects." Blood 106, no. 11 (2005): 4283. http://dx.doi.org/10.1182/blood.v106.11.4283.4283.

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Abstract Objectives: To assess the safety, pharmacokinetics (PK), pharmacodynamics and immunogenicity of single and fractionated IV doses of an erythropoietic mimetic antibody fusion protein, CNTO 528, in healthy males. Methods: In this randomized, single-blind, and placebo (PBO)-controlled study, 44 subjects were enrolled in 5 dose cohorts. In Stage 1, 35 subjects received a single IV administration of 0.03, 0.09, 0.3, 0.9 mg/kg CNTO 528 or PBO. In Stage 2, 9 subjects received fractionated IV administrations of CNTO 528 or PBO on Days 1, 3 and 5 (3 infusions of 0.09 mg/kg or PBO). Results: Ph
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Zhong, Lishan, Yanting Wu, Chen Huang, et al. "Acute toxicological evaluation of AT-533 and AT-533 gel in Sprague-Dawley rats." BMC Pharmacology and Toxicology 24, no. 1 (2023). http://dx.doi.org/10.1186/s40360-023-00696-5.

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Abstract Background AT-533 is a novel heat shock protein 90 inhibitor that exerting anti-inflammatory, antiviral, and antitumor efficacy. Furthermore, the gel made of AT-533 as raw material named AT-533 gel has the function of repairing keratitis and dermatitis caused by herpes virus infection. However, the acute safety evaluation of AT-533 and AT-533 gel has not been conducted. Methods and results Herein, we performed acute toxicological studies of AT-533 and AT-533 gel in Sprague-Dawley rats. Fifteen-day acute toxicity study of AT-533 was conducted in both male and female Sprague-Dawley rats
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Fujihira, Kyoko, Yuka Hamada, Miki Haramura, Katsuhiko Suzuki, and Masashi Miyashita. "The effects of different temperatures of post-exercise protein-containing drink on gastric motility and energy intake in healthy young men." British Journal of Nutrition, April 27, 2021, 1–9. http://dx.doi.org/10.1017/s0007114521001392.

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Abstract The present study examined the effects of different temperatures of protein-containing drink after exercise on subsequent gastric motility and energy intake in healthy young men. Twelve healthy young men completed three, 1-d trials in a random order. In all trials, the subjects ran on a treadmill for 30 min at 80% of maximum heart rate. In exercise + cold drink (2°C) and exercise + hot drink (60°C) trials, the subjects consumed 300 ml of protein-containing drink (0·34 MJ) at 2°C or 60°C over a 5-min period after exercise. In the exercise (i.e. no preload) trial, the subjects sat on a
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Basha, Omar M., and Badie I. Morsi. "Effects of Chemical Reactions on the Local Hydrodynamics in Slurry Bubble Column Reactors Operating under Typical Fischer-Tropsch Process Conditions – Ii." International Journal of Chemical Reactor Engineering 17, no. 9 (2019). http://dx.doi.org/10.1515/ijcre-2018-0244.

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AbstractOur rigorously validated Computational Fluid Dynamics (CFD) model (Basha et al. 2016) was previously used to predict the effects of gas sparger designs and internals configurations on the local hydrodynamics in a pilot-scale and a conceptual large-scale slurry bubble column reactors (SBCRs) (Basha and Morsi 2018). In this study, the CFD model was used to predict the effect of incorporating the F-T reaction kinetics on the local hydrodynamics in the pilot-scale (0.3-m ID, 3-m height) and the overall performance of the pilot-scale and an industrial-scale (5.8-m ID, 42-m height) SBCRS, bo
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