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Journal articles on the topic '025.063 337 091 638 4'

Author: Grafiati

Published: 4 June 2021

Last updated: 8 February 2022

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1

Kepert, Cameron J., Peter C. Junk, Brian W. Skelton, and Allan H. White. "Structural Systematics of Rare Earth Complexes. XX (Maximally) Hydrated Rare Earth Sulfates and the Double Sulfates (NH4)Ln(SO4)2.4H2O (Ln = La, Tb)." Australian Journal of Chemistry 52, no. 6 (1999): 601. http://dx.doi.org/10.1071/ch98050.

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Room-temperature single-crystal X-ray studies carried out on trivalent rare earth sulfate hydrates, Ln2(SO4)3.xH2O, crystallized at local ambience suggest the following arrays to be prevalent. For Ln = La, the nonahydrate is found, hexagonal P 63/m, with conventional R on |F| 0·023 for No 1159 ‘observed’ (I >3σ(I)) diffractometer reflections (redetermination). Although for Ln = Ce a similar structure has been previously recorded, we have obtained that adduct as the monoclinic C 2/c, Z = 4, octahydrate, a phase also found for Ln = Lu and diverse representative intermediate lanthanoids: a ≈ 1

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Zhang, Lingyun, Xiujuan Qu, Yuee Teng, et al. "Efficacy of Thalidomide in Preventing Delayed Nausea and Vomiting Induced by Highly Emetogenic Chemotherapy: A Randomized, Multicenter, Double-Blind, Placebo-Controlled Phase III Trial (CLOG1302 study)." Journal of Clinical Oncology 35, no. 31 (2017): 3558–65. http://dx.doi.org/10.1200/jco.2017.72.2538.

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Purpose We examined the efficacy and safety of thalidomide (THD) for the prevention of delayed nausea and vomiting in patients who received highly emetogenic chemotherapy (HEC). Patients and Methods In a randomized, double-blind, active-controlled, phase III trial, chemotherapy-naive patients with cancer who were scheduled to receive HEC that contained cisplatin or cyclophosphamide-doxorubicin/epirubincin ≥ 50 mg/m2 regimens were randomly assigned to a THD group (100 mg twice daily on days 1 to 5) or placebo group, both with palonosetron (0.25 mg on day 1) and dexamethasone (12 mg on day 1; 8

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Park, Junghyun, and Marc Rodger. "Retrospective Cohort of Unprovoked Venous Thromboembolism Patients: What Proportion Have Potent Thrombophilias Necessitating Indefinite Anticoagulants?" Blood 126, no. 23 (2015): 2318. http://dx.doi.org/10.1182/blood.v126.23.2318.2318.

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Introduction Thrombophilia testing in unprovoked venous thromboembolism patients (VTE) is controversial. Common thrombophilias such as Factor V Leiden or prothrombin gene variant appear to not importantly increase the risk of VTE recurrence, and thus are not considered in anticoagulation management decisions. However, patients with potent thrombophilias such as antiphospholipid antibodies (APLA), antithrombin deficiency, protein C and S deficiency, and homozygous genetic thrombophilias or combined defects are at higher risk of recurrence and it is recommended that they receive long-term antico

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4

Koemel, Nicholas A., Christina M. Sciarrillo, Katherine B. Bode, et al. "Postprandial Metabolism and Vascular Function: Impact of Aging and Physical Activity Level." International Journal of Sport Nutrition and Exercise Metabolism 30, no. 6 (2020): 412–19. http://dx.doi.org/10.1123/ijsnem.2020-0063.

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The consumption of a high-fat meal can induce postprandial lipemia and endothelial dysfunction. The authors assessed the impact of age and physical activity on metabolic and vascular outcomes following meal consumption in healthy adults. The authors recruited four groups: younger active (age 22.1 ± 1.4 years; n = 9), younger inactive (age 22.6 ± 3.7 years; n = 8), older active (age 68.4 ± 7.7 years; n = 8), and older inactive (age 67.7 ± 7.2 years; n = 7). The metabolic outcomes were measured at the baseline and hourly for 6 hr post high-fat meal consumption (12 kcal/kg; 63% fat). Flow-mediate

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Heikura, Ida A., Louise M. Burke, Dan Bergland, Arja L. T. Uusitalo, Antti A. Mero, and Trent Stellingwerff. "Impact of Energy Availability, Health, and Sex on Hemoglobin-Mass Responses Following Live-High–Train-High Altitude Training in Elite Female and Male Distance Athletes." International Journal of Sports Physiology and Performance 13, no. 8 (2018): 1090–96. http://dx.doi.org/10.1123/ijspp.2017-0547.

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Purpose: The authors investigated the effects of sex, energy availability (EA), and health status on the change in hemoglobin mass (ΔHbmass) in elite endurance athletes over ∼3–4 wk of live-high–train-high altitude training in Flagstaff, AZ (2135 m; n = 27 women; n = 21 men; 27% 2016 Olympians). Methods: Precamp and postcamp Hbmass (optimized carbon monoxide rebreathing method) and iron status were measured, EA was estimated via food and training logs, and a Low Energy Availability in Females Questionnaire (LEAFQ) and a general injury/illness questionnaire were completed. Hypoxic exposure (h)

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Sasaki, Koji, Ildefonso Ismael Rodriguez-Rivera, Hagop M. Kantarjian, et al. "Correlation of Lymphocyte Count with Treatment Response to Tyrosine Kinase Inhibitors in Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase." Blood 124, no. 21 (2014): 4538. http://dx.doi.org/10.1182/blood.v124.21.4538.4538.

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Abstract Background: Total lymphocyte count (TLC) has been shown to correlate with outcomes in patients (pts) with acute leukemia. The clinical correlation to TLC in pts with chronic myeloid leukemia in chronic phase (CML-CP) who were treated with a tyrosine-kinase inhibitor (TKI) is unclear. Methods: Lymphocyte data in pts with newly diagnosed CML-CP who were enrolled in consecutive or parallel clinical trials with front-line imatinib (IM), nilotinib (Nilo), or dasatinib (Dasa) were collected at the time of diagnosis, and 3 and 6 months (M) after the start of TKI. Relative lymphocytrosis (RLC

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7

D’cruz, D., G. Eriksson, Y. Green, et al. "POS0696 SAFETY AND EFFICACY OF BELIMUMAB IN OLDER ADULTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS: RESULTS OF AN INTEGRATED ANALYSIS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 596.1–596. http://dx.doi.org/10.1136/annrheumdis-2021-eular.2217.

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Background:Systemic lupus erythematosus (SLE) is a chronic, autoimmune disease characterised by persistent B-cell activation. Belimumab (BEL), a monoclonal antibody that inhibits B-lymphocyte stimulator, is approved in patients aged ≥5 years with active autoantibody-positive SLE; however, safety and efficacy data of BEL in older adults are limited.Objectives:Assess the safety and efficacy of BEL in older adults with SLE.Methods:A meta-analysis (GSK study 116559) was performed on the subpopulation of patients aged ≥65 years and compared with the overall population pooled from six controlled, re

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Walschot, Luc H. B., Robert J. F. Laheij, and André L. M. Verbeek. "Outcome after Endovascular Abdominal Aortic Aneurysm Repair: A Meta-Analysis." Journal of Endovascular Therapy 9, no. 1 (2002): 82–89. http://dx.doi.org/10.1177/152660280200900114.

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Purpose: To determine the frequencies of complications and risk factors for complications following endovascular abdominal aortic aneurysm (AAA) repair (EVAR). Methods: Thirty-nine articles published between October 1995 and October 1999 in English, German, French, or Dutch were identified in electronic databases. All articles reported perioperative (30-day) complications on 2387 patients, while postoperative complications (>30 days) were reported on 1645 patients in 30 of 39 studies. Data were pooled and subjected to multivariable logistic regression analysis to identify risk factors for d

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Ganhão, S., S. Garcia, B. M. Fernandes, et al. "SAT0416 ENTHESITIS AND CLINICAL RESPONSE IN PSORIATIC ARTHRITIS: REAL-LIFE DATA." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1161.1–1161. http://dx.doi.org/10.1136/annrheumdis-2020-eular.4543.

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Background:Psoriatic arthritis (PsA) is an inflammatory arthritis that is characterized by a broad spectrum of clinical conditions, including axial skeletal involvement, enthesitis, dactylitis, uveitis and arthritis. Among those, enthesitis, the inflammation of the junction where the tendon, ligament or joint capsule inserts into the bone, is assigned to be the hallmark, affecting 35–50% of patients. Several clinical methods have been developed to measure it, including The Maastricht AS Enthesitis Score (MASES) index, which tests 13 entheses and the Spondyloarthritis Research Consortium of Can

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Ritchlin, C. T., P. Rahman, P. Helliwell, et al. "AB0538 POOLED SAFETY RESULTS FROM TWO PHASE-3 TRIALS OF GUSELKUMAB IN PATIENTS WITH PSORIATIC ARTHRITIS THROUGH 1 YEAR." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1300–1301. http://dx.doi.org/10.1136/annrheumdis-2021-eular.1334.

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Background:DISCOVER 1 & 2, two double-blind, phase-3, psoriatic arthritis (PsA) trials of guselkumab (GUS, an IL-23 inhibitor), demonstrated significant improvement with GUS vs placebo (PBO) in signs and symptoms of PsA, with good tolerability, at week (w) 24 during the PBO-controlled period.1,2 Beyond w24, all patients (pts) switched to GUS. Continued treatment maintained efficacy through w52.3,4Objectives:To describe pooled safety results from the DISCOVER 1 & 2 trials through 1-year of GUS treatment.Methods:Adults with active PsA (DISCOVER 1: ≥3 tender/swollen joints and C-Reactive

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Cserti, Christine M., Jennifer Braunstein, and Melody J. Cunningham. "Red Cell Alloantibodies and Autoantibodies in Thalassemia Patients at Childrens’ Hospital Boston: Incidence and Influential Factors." Blood 108, no. 11 (2006): 963. http://dx.doi.org/10.1182/blood.v108.11.963.963.

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Abstract Introduction: Alloantibodies [alloAb] or autoantibodies [autoAb] may represent complications of, and pose relevant barriers to, transfusion in thalassemia patients. A high incidence of alloAb (21%) and autoAb (9.2%) was noted in the Thalassemia Clinical Research Network (TCRN), with an apparent but unresolved association with factors such as the transfusion of nonleukoreduced products, or status post splenectomy. [ASH 2005] Methods: To learn more about the specific types and timing of serologic abnormalities, the histories of all 44 patients living with thalassemia, born between 1951

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12

Winthrop, K., L. Calabrese, F. Van den Bosch, et al. "FRI0141 CHARACTERIZATION OF SERIOUS INFECTIONS WITH UPADACITINIB IN PATIENTS WITH RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 654–55. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2761.

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Background:Upadacitinib (UPA) is a selective and reversible Janus kinase (JAK) inhibitor with an approved dose of 15 mg once daily (QD) for the treatment of rheumatoid arthritis (RA). Patients (pts) receiving JAK inhibitors have been reported to be at increased risk of developing serious infection events (SIE) and opportunistic infections (OI).Objectives:To evaluate the incidence of SIEs and OIs in pts with RA receiving UPA and active comparators in the Phase 3 SELECT clinical trial program.Methods:The exposure-adjusted event rate (EAER) per 100 patient-years (E/100 PY) of SIEs and OIs was det

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Orbai, A. M., L. C. Coates, A. Deodhar, et al. "POS1029 GUSELKUMAB-TREATED PATIENTS WITH PSORIATIC ARTHRITIS ACHIEVED CLINICALLY MEANINGFUL IMPROVEMENTS IN GENERAL HEALTH OUTCOMES MEASURED WITH PROMIS-29 THROUGH 52 WEEKS: RESULTS FROM THE PHASE 3 DISCOVER-1 TRIAL." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 785–86. http://dx.doi.org/10.1136/annrheumdis-2021-eular.471.

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Background:In the DISCOVER-1 study, the interleukin-23 p19 subunit inhibitor guselkumab (GUS) demonstrated robust efficacy across joint and skin clinical manifestations of psoriatic arthritis (PsA).1 Patients (pts) with PsA also experience a broad range of symptoms that negatively impact health-related quality of life (eg, pain, fatigue, anxiety, depression, sleep disturbance, poor physical function).2Objectives:Assess the treatment effect of GUS on general health outcomes in pts with PsA in the DISCOVER-1 trial through Week (W) 52 using the Patient-Reported Outcomes Measurement Information Sy

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14

Dao, An T. T., Kohei Hosokawa, Chiharu Sugimori, et al. "A Profound Decrease in FoxP3+Helios+CD4+ T Cells in a Subset of Patients with Acquired Aplastic Anemia and Pure Red Cell Aplasia: A Common Mechanism Underlying a Dependency on Cyclosporine." Blood 124, no. 21 (2014): 4384. http://dx.doi.org/10.1182/blood.v124.21.4384.4384.

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Abstract Background: A subset of patients with acquired aplastic anemia (AA) require low-dose cyclosporine (CsA) to maintain good hematopoietic function even after achieving a remission with immunosuppressive therapy (IST). Such CsA-dependent AA offers opportunities to clarify the immune mechanisms underlying bone marrow (BM) failure, but little is known about the mechanism(s) underlying this condition except for its close association with a particular HLA-class II allele DRB1*15:01. Regulatory T cells (Tregs), defined as CD4+CD25highFoxP3+ T cells, have been shown to be decreased in patients

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15

Diwan, Abhinav, Janaka Wansapura, Scot Matkovich, et al. "Abstract 635: Inhibiting Reactive Apoptosis by Cardiac-specific Nix Ablation Prevents Decompensation of Pathological Hypertrophy." Circulation 116, suppl_16 (2007). http://dx.doi.org/10.1161/circ.116.suppl_16.ii_116-c.

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Background : Compensated pathological hypertrophy will inevitably remodel, leading to functional decompensation. Postulated mechanisms include cardiomyocyte dropout, changes in myocardial matrix, and altered cardiac metabolism. Transcriptional modulation of apoptosis-regulating Bcl2 family members is associated with myocardial hypertrophy, but a role for programmed cardiomyocyte death in left ventricular (LV) remodeling has not been established. Methods and Results : Proapoptotic Nix, which is transcriptionally upregulated in pressure overload and Gαq-dependent hypertrophies, was subjected to

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16

Crobach, M. J. T., D. W. Notermans, C. Harmanus, I. M. J. G. Sanders, S. C. De Greeff, and E. J. Kuijper. "Community-Onset Clostridioides Difficile Infection in Hospitalized Patients in The Netherlands." Open Forum Infectious Diseases 6, no. 12 (2019). http://dx.doi.org/10.1093/ofid/ofz501.

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Abstract Background Clostridioides difficile infection (CDI) is increasingly reported in the community. The aim of this study was to analyze characteristics of hospitalized patients with community-onset CDI (CO-CDI). Methods In the Netherlands, 24 hospitals (university-affiliated and general hospitals) participate in the sentinel CDI surveillance program. Clinical characteristics and 30-day outcomes of hospitalized patients &gt;2 years old diagnosed with CDI are registered. Samples of these patients are sent to the national reference laboratory for polymerase chain reaction ribotyping. Dat

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