Academic literature on the topic '03-30-22'

En el presente trabajo se reportan las especies de anfípodos bentónicos de los subórdenes Amphilochidea y Senticaudata de la Plataforma Continental Centro Norte del Perú (03°24'S - 79°30'W a 09°00'S - 81°30'W) colectadas durante la estación de otoño. A partir de 136 puntos de muestreo, distribuidas en entre 22 y 372 m, se determinaron 28 taxa de anfípodos, pertenecientes a 15 familias; 14 especies consideradas como nuevos registros para el mar peruano. La familia Ampeliscidae fue la más diversa, con 11 especies. Se incluye información taxonómica descriptiva y distribución geográfica referenciada.

This research aims to determine the effect of team cohesion on work engagement with the mediating role of psychological empowerment. JD-R model is used to explain the phenomenon. We learn about how people who are engaged in ongoing working in team give an impact on people work engagement. Based on quantitative research from 557 participants from Indonesian military forces that were temporarily placed to carry out peace missions on conflict countries. By using Process to analyze data, we found that psychological empowerment partially mediate the relationship of team cohesion on work engagement (path a: Coeff = .29, SE = .04, p < .01, 95%CL .22 to .37; path b: Coeff = .23, SE = .03, p < .01, 95%CL .17 to .30; path c’, Coeff = .10, SE = .03, p < .01, 95%CL .04 to .17).

299 Background: Administrative claims data are widely used to identify treatment patterns. However, as new drugs are brought to clinical practice, treatment regimens become more complicated for cancer patients receiving both chemotherapy and biologic agents. We evaluated the influence of using different treatment length algorithms on identification of treatment patterns for patients with metastatic colorectal cancer (mCRC). Methods: We identified patients aged 18 or older with at least one primary CRC diagnosis between 01/01/2008 and 03/31/2012 in the MarketScan databases. mCRC patients were included if claims indicated the presence of distant metastases (ICD-9-CM codes: 196.x, 197.0 to 197.4, 197.6 to 197.8, 198.x, and 199.0). All treatment claims were extracted and patients were followed for more than 6 months, until end of enrollment or study end date (03/01/2013). We identified all chemotherapy and/or biologic drugs given to a patient during 30, 60, or 90 days after initiation of treatment and compared differences in type and number of treatment lines (TLs). Results: A total of 2,046 mCRC patients received at least one TL. Using a 30-day cutoff period, 30% patients received 1 TL; 30% received 2 TLs; and 40% received ≥3 TLs. Results changed after using a 60-day cutoff period: 39% patients with 1 TL, 33% with 2 TLs, and 28% with ≥3 TLs. If using 90 days as a cutoff period, 44% received 1 TL; 35% received 2 TLs; and 22% received ≥3 TLs. For all cutoff periods, the most common first TL prescribed were FOLFOX +/- bevacizumab and 5-FU/LV. For patients receiving a second TL, FOLFOX was most frequently prescribed if using a 30-day or 60-day cutoff, while FOLFIRI/bevacizumab had a higher prescription rate with a 90-day cutoff. Regimens varied in third and fourth-line therapy using different cutoff periods and FOLFIRI +/- bevacizumab was more frequently used than other regimens. Conclusions: The cutoff period did not significantly influence treatment regimens detected for first and second TL. Using a 30-day cutoff period resulted in 30% patients with one TL and 40% with three or more TLs, while with a 90-day cutoff, 44% patients received one TL and only 22% received three or more TLs.

Abstract Introduction Approximately 40%-60% of menopausal women suffer from sleep disturbances, commonly linked to vasomotor symptoms of hot flashes and night sweats. This study aims to evaluate sleep patterns and quality in peri- and post-menopausal women using actigraphy. Methods Thirty-nine participants (45 to 65y, BMI 25.62±3.02 kg/m², Insomnia Severity Index (ISI) score 10.98±4.10) experiencing menopausal symptoms underwent actigraphy recordings of sleep onset/offset, duration, and mid-sleep times over at least three consecutive nights with 357 nights of data analysed. Results The vasomotor subscales (hot flash and night sweat, Greene Climacterics questionnaire) yielded a score of 2.43±1.15 (compared to general population: 1.79±1.12 and menopause clinic: 4.41±1.70). Sleep onset times ranged from 19:06-03:16 with the most common time at 22:00-22:59 (31.1%) followed by 23:00-23:59 (27.5%). Sleep offset times ranged from 03:39-11:28 with the most common time at 06:00-06:59 (34.5%). The average sleep duration ranged from 231 to 819 minutes with the most common duration 470-529 min (33.6%) with 43.1% of nights with <8h of sleep. The mid-sleep times ranged from 23:50-05:19 with the most common mid-sleep time at 02:30-02:59(19%), followed by 02:00-02:29 (17.9%) and 03:00-03:29 (17.4%). Discussion In consideration of demographic factors, moderate vasomotor symptoms and some irregularities in sleep-wake timing, the menopausal women in this study largely have adequate sleep duration of around eight or more hours. It is likely that their symptoms were not as severe as the clinic sample. However, it is not clear if better sleep in this group is linked to increased awareness of sleep as a health behaviour.

ABSTRACT Objective: To investigate the potential relationship between the human leukocyte antigen (HLA) type (class I and II) and the response to several disease-modifying therapies (DMTs) in patients with multiple sclerosis (MS). Methods: We analyzed clinical data of 87 patients with MS at the beginning and end of each type of DMT including the disease duration, Expanded Disability Status Scale and Multiple Sclerosis Severity Score (MSSS). Genotyping of HLA-DRB1, HLA-DPB1, HLA-DQB1, HLA-A, HLA-B and HLA-C alleles were identified using high-resolution techniques. Statistical correlation between the HLA type and response to DMTs was done using the initial and final MSSS. Results: Statistical relationships (p < 0.05) were found for only 15 of 245 alleles tested. There was a reduction in the MSSS for patients treated with corticosteroids (DRB1*15:01, DPB1*04:01, DQB1*02:01 and DQB1*03:01), azathioprine (DRB1*03:01, DPB1*04:01, DQB1*03:02, DQB1*06:02, HLA-C*07:02), interferon β-1a 22 mcg (DRB1*11:04, DQB1*03:01 and DQB1*03:02), interferon β-1a 30 mcg (DPB1*02:01, HLA-C*05:01) and interferon β-1b (DQB1*02:01). Conclusion: These findings suggest a few relationships between the HLA and response to DMTs in the disability for some types of HLA class I and II alleles in a specific subset of MS patients.

The family Bathylagidae contains eight genera and 22 species, of which only five occur in the Southwest Atlantic. Until recently, only adult specimens of the bathylaginin Melanolagus bericoides had been recorded off southern Brazil, between the Santa Marta Cape and Rio Grande (31° S and 49° W). The present work reports the first occurrence of Dolicholagus longirostris larvae on the northern Brazilian coast, expanding its distribution in the Southwest Atlantic. The two specimens found were collected near the mouth of the Amazon River (02° 00' 19" N, 47° 03' 30" W, and 00° 49' 06" N, 46° 25' 09" W).

Caso N.º 21. Ententes: STJCE 16 febrero 2006, As. C-111/04, Adriatica di Navegazione/Comisión Caso N.º 22. Ententes: STPI (Sala Cuarta) 15 marzo 2006. As. T-26/02, Daiichi Pharmaceutical Co. Ltd./Comisión & Caso N.º 23. Ententes: STPI (Sala Cuarta) 15 marzo 2006. As. T-15/02, BASF AG/Comisión Caso N.º 22. Ententes: STPI (Sala Cuarta) 15 marzo 2006. As. T-26/02, Daiichi Pharmaceutical Co. Ltd./Comisión Caso N.º 23. Ententes: STPI (Sala Cuarta) 15 marzo 2006. As. T-15/02, BASF AG/Comisión Caso N.º 24. Ententes: STJCE 5 abril 2006, As. T-279/02, Degussa AG/ Comisión Caso N.º 25. Ententes: STJCE 6 abril 2006, As. C-551/03 P, General Motors BV/Comisión Caso N.º 26. Ententes: STPI 2 mayo 2006, As. T-328/03, O2 GmbH y Co. OHG/Comisión Caso N.º 27. Ententes: STJCE 18 mayo 2006, As. C-397/03 P, Archer Daniels Midland Co., y Archer Daniels Midland Ingredients Ltd./Comisión Caso N.º 28. Ententes: STJCE 30 mayo 2006, As. T-198/03, Bank Austria Creditanstalt AG/Comisión Caso N.º 29. Ententes: STJCE (Sala Segunda) 29 junio 2006, As. C-289/04 P, Showa Denko KK/Comisión Caso N.º 30. Ententes: STJCE (Sala Segunda) 29 junio 2006, As. C-308/04 P, SGL Carbón AG/Comisión Caso N.º 31. Ententes: STJCE 13 julio 2006, As. C-74/04, Comisión/Volkswagen AG Caso N.º 32. Ententes: STJCE 13 julio 2006, Ass. C-295/04 a C-298/04, Vincenzo Manfredi y otros/Lloyd Adriatico Assicurazioni SpA y otros Caso N.º 33. Abuso de posición dominante: STJCE 11 julio 2006, As. C- 205/03 P, Federación Española de Empresas de Tecnología Sanitaria (FENIN)/Comisión Caso N.º 34. Concentraciones: Dec. Com. 6 octubre 2004, As. COMP/M. 3099- Areva/Urenco Caso N.º 35. Concentraciones: Dec. Com. 18 octubre 2005, As. COMP/ M.3894-Unicrédito/HVB Caso N.º 36. Concentraciones: Dec. Com. 10 enero 2006, As. COMP/ M.4035-Telefónica/O2 Caso N.º 37. Concentraciones: Dec. Com. 24 enero 2006, As. COMP/M. 3942-Adidas/Reebok Caso N.º 38. Concentraciones: Dec. Com. 15 febrero 2006, As. COMP/ M.4087-Eiffage/Macquarie/APRR Caso N.º 39. Concentraciones: STPI 23 febrero 2006, As. T-282/02, Cementbow/Comisión Caso N.º 40. Concentraciones: STPI (Sala Tercera), 14 julio 2006, As. T.417/05, Endesa/Comisión Caso N.º 41. Concentraciones: STPI 23 julio 2006, As. T-464/04, Impala/ Comisión Caso N.º 42. Libre acceso al mercado: STPI (Sala Quinta) 7 junio 2006, Ass. T-213/01 y T-214/01, Österreichische Postsparkasse AG y Bank für Arbeit und Wirtschaft AG/Comisión.

ЦЕЛЬ: проанализировать результаты анкетирования видов хронотипов, степени физической адаптации,
 особенностей организации сна и бодрствования у лиц с нарушением углеводного обмена (НУО).
 МАТЕРИАЛЫ И МЕТОДЫ: пациенты были распределены на 5 групп: 1 группа (n-80) – контрольная
 без висцерального ожирения, 2 группа (n-80) – лица с ожирением, 3 группа (n-80) – лица с предиабетом,
 4 группа (n-80) – лица с сахарным диабетом 2 типа (СД2) с длительностью заболевания до 5 лет и 5 группа
 (n-80) – лица с СД2 с микроангиопатиями. Среднее значение окружности талии в группах с ожирением
 и НУО составило 98,6±3,4 см – висцеральное ожирение. Среди исследуемых лиц 77% женщин и 23% муж-
 чин, средний возраст – 58,6±3 лет. Анкетирование проводилось по опросникам: Horne-Austberga, IPAQ,
 MCTQ и PSQI.
 РЕЗУЛЬТАТЫ: по результатам теста Horne-Austberga во всех группах преобладает промежуточный
 хронотип: наибольшее количество – в группе с предиабетом (89%), а наименьшее – с СД2 до 5 лет (43%).
 Во всех группах наблюдался поздний отход ко сну: 1 группа – 23:30–01:00, 2 группа – 22:45–00:50, 3 группа —
 22:55–00:30, 4 группа – 22:35–00:30 и 5 группа – 22:40–00:29, с увеличением продолжительности сна до 08:03,
 08:24, 08:15, 09:00, 08:37 соответственно. По данным опросника IPAQ в контрольной группе у 100% – доста-
 точный уровень физической активности. Доля пациентов с гиподинамией в возрасте 40–65 лет преобла-
 дала в группе с предиабетом (88%), старше 65 лет – в группе с СД2 с микроангиопатиями (54%). Результаты
 Мюнхенского теста демонстрируют смещение времени засыпания и пробуждения на позднее время в рабо-
 чие и выходные дни: тенденция наибольшего смещения наблюдалась в группах с НУО – на 76 и 42 минуты
 соответственно, а наименьшего – в контрольной группе здоровых – на 27 и 33 минуты. При анализе данных
 Мюнхенского и Питтсбургского тестов выявлены особенности в расхождении между временем засыпания
 и пробуждения на 41 и 21 минуты только в группе с СД2 с микроангиопатиями.
 ВЫВОДЫ: преобладание промежуточного хронотипа во всех исследуемых группах, позднее время
 пробуждения и засыпания, увеличение продолжительности сна, хроническая разница между эндогенными
 часами в рабочие и выходные дни при наличии факторов риска (висцеральное ожирение, гиподинамия)
 свидетельствуют в пользу формирующегося «джетлага» и опосредованно повышают риск прогрессиро-
 вания НУО. Изменения качества сна за последний 1 месяц (по результатам опросника PSQI) может быть
 обусловлено современным ритмом жизни и связано со снижением адаптационных механизмов в поддер-
 жании метаболического равновесия. Десинхроноз является одним из дополнительных факторов риска
 развития НУО. Дальнейшее изучение циркадианных ритмов позволит персонализировано подходить
 к прогнозированию НУО при осуществлении профилактических мероприятий.

INTRODUÇÃO: O infarto agudo do miocárdio (IAM) em pacientes jovens, manifesta-se comumente como angina típica e supradesnivelamento do segmento ST. Entre os fatores de risco destacam-se tabagismo, dislipidemias, história familiar de doença arterial coronariana precoce e uso de cocaína. A prevalência de doenças reumatológicas e trombofilias é maior neste grupo, devendo ser investigadas. Este relato torna-se relevante ao apresentar caso de IAM com supradesnivelamento do segmento ST (IAMCSST) em paciente com menos de 30 anos, com diagnóstico tardio e complicações. METODOLOGIA: Trata-se de uma revisão de prontuário, seguida de entrevista com acompanhante/cuidador por meio de termo de consentimento livre esclarecido e uma revisão bibliográfica. DESCRIÇÃO: Paciente S.S.M., sexo masculino, 24 anos, com histórico de crise de ausência, procurou atendimento em 17/02/2022, queixando-se de precordialgia irradiando para braço esquerdo e epigastralgia, sendo diagnosticado com refluxo gastroesofágico. Evoluiu com cefaleia, distúrbios visuais e perda súbita da força muscular em membro superior direito. Consultou-se com neurologista e cardiologista no dia 22/02/2022, sendo evidenciado acidente vascular cerebral (AVC) isquêmico e IAMCSST. Foi encaminhado ao hospital. Encontrava-se consciente, taquicárdico, afásico, com déficit motor grau V de hemicorpo direito. Na TC de crânio de crânio apresentou área hipodensa parenquimatosa cerebral têmporo-occipital esquerda com discreto efeito expansivo local à efeito de insulto isquêmico, e ecodopplercardiografia revelou hipocinesia importante ântero-médio-apical, com achinesada do ápice do ventrículo esquerdo. Iniciou-se antiagregação plaquetária, anticoagulação, betabloqueador, inibidor da ECA, estariam sintomáticos e controle da diurese. No dia 11/03/2022 foi encaminhado ao cateterismo cardíaco com evidência de lesão em 95% do terço proximal da artéria descendente anterior (ADA) e fluxo distal TIMI II. O exame prosseguiu com angioplastia coronariana da ADA, com implante de 01 stent farmacológico. Recebeu alta hospitalar e após 30 dias do evento, segue sem rehospitalizações e novas complicações. CONCLUSÃO: O caso relatado enfatiza a importância da investigação e descarte de IAM em pacientes jovens, em situações de dor torácica típica, mesmo sem fatores de risco clássicos. O diagnóstico, instituição do tratamento, prevenção de complicações, investigação etiológica e descarte de trombofilias devem ser realizados de forma ágil.

Founded in 1993 within the "Alexandru Ioan Cuza" University in Iași, the section of Cultural Heritage (later called Sacred Art) will become the first accredited section of university education in Romania, with the aim of training specialists in the field of conservation and restoration of mobile cultural heritage (old book icon and polychrome wood). In 1999, a new specialization appeared, Painting, and in 2017 the study program was accredited according to the standards in the field of Visual Arts. During the 30 years, the Sacred Art section carried out an intense didactic, artistic creation and research activity in the field of Art History, Investigation, Conservation and Restoration of mobile cultural heritage.

This article brings to the fore the need to approach current education from the perspective of cultural diversity, taking into account its religious-moral dimension. It can be seen that the religiousmoral dimension of education leads to the acceptance of cultural diversity, as a norm of conduct, this being the ideal towards which any society tends, at all times. All the more the reference is made to the approach to diversity with flexibility and tolerance in the last 30 years, from the perspective of sociocultural, linguistic, psychological or physical differences between students. The school, as an educational and cultural institution, aims to offer equal opportunities to everyone, the opportunity to learn at their own pace and adapted expression of individual personality traits. From a global perspective, cultural diversity implies the application of the principle of normalization. This ensures the access of all people to current living conditions, regardless of ethnicity, race, religion, culture, social group, etc. Each student, as a partner in the act of teaching-learning-evaluation, comes with his own experience, has his own personality, which we find in collaborative relationships, learning style, interest in existential issues and, necessarily, in the cultural context to which he belongs.

The nappe flow regime is divided into three sub-types, characterized by the formation or absence of hydraulic jumps on the bed of the stairs. The skimming flow regime is sub-divided considering the geometry of the steps and the flow conditions that lead to different configurations of the flow fields near the steps. For this, we have made an experimental approach in the laboratory of civil engineering at the University of Laghouat (Algeria), in three (03) models: model A (4cm x 7.5cm 4cmx) and model B (8cm x 7.5cm 8cmx), and the third model C size (12cm x 12 cm x 7.5 cm) developed "Plexiglas." Three slopes were studied in this experiment:  = 20 °, 30 ° and  =  = 45 ° for the three models, with flow rates ranging from q = 0.96 l / s / ml up to q = 33.02 l / s / ml.The purpose of this experimental study is to show the evolution of the velocity profiles in the cross sections of the flows, and pressure variations in the three studied models. The analysis of our results led us to conclude that, The result obtained in the model B and C where the flow is in nappe flow; the pressure field increases in horizontally steps and decreases in vertically steps; this is due to the effect of the impact of the flow on the step; and against the pressure in step is below atmospheric pressure (vacuum). Furthermore, the speeds increase significantly with increasing rate of flow and accelerated more than one moves downstream; In the last, for the skimming flow, longitudinal flow velocity distribution is nearly constant which is shown in the uniform area flow.

Introduction: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), is a non-atherosclerotic, nonamyloid, hereditary cerebral disease of small vessels and capillaries caused by mutations in the NOTCH-3 gene located on chromosome 19. The presence of granular osmophilic material (GOM) deposition in the smooth muscle cells of vessel walls is the pathological hallmark of arteriopathy in CADASIL. GOM deposits in the basal lamina of smooth muscle of small vessels are pathognomonic for CADASIL. The presence of GOM in capillary blood vessels of the skin and muscle in biopsy and genetic studies (NOTCH-3 analysis) plays a key diagnostic role. Biopsy tests have high specificity (up to 100%) and low sensitivity (less than 50%). The NOTCH-3 test has been proposed as the primary diagnostic approach, allowing detection of 90% of affected individuals. CADASIL has an estimated prevalence between 2 and 5 in 100,000, and the phenotypic study demonstrates different clinical symptoms in the course of the disease within the same family. The average age of onset of clinical symptoms varies between 48.3 years in men and 52.2 years in women. Characteristic symptoms of migraine, stroke or TIA (transient ischemic attack), behavioral changes, early and progressive cognitive changes associated with leukoencephalopathy on imaging studies. The large association of symptoms often causes the diagnosis of CADASIL to be delayed. In this case, we had an association of gait ataxia within the framework of motor alterations, demonstrating the wide range of symptomatology of the pathology. This case report presents a familial course that started outside the most prevalent age group in the studies described and with an atypical presentation in an affected generation. Case reports: Case 01: woman, 68 years old, started progressively forgetting to perform household activities after the age of fifty, associated with primarily generalized myoclonic epileptic seizures, evolving rapidly within five years to walking apraxia with the use of a wheelchair and tonic-tonic epileptic seizures. bilateral clonic disorders, comprehension aphasia and bradypsychism. Relatives report previous migraine without chronic aura and REM (rapid eye movement sleep) sleep behavior disorder (RMSD). On neurological examination, severe ataxia with bilateral dysdiadochokinesia associated with bilateral hypometric index-index. Bilateral ROT 4+/4+ with bilateral Hoffman and Babinski signs. MMSS and MMII with FGM 4/5 proximal and distal. Case 02: woman, 36 years old, pastry chef, had episodes of forgetting about everyday activities of her work, progressive in the last three years (cake recipes, budget accounts, orders placed) associated with confusion for spatial location on the way home/ work, evolving to apraxia in writing letters and words and difficulty with calculations associated with monoparesis of the right lower limb for twelve months with progression to paresis of the lower limbs after six months and evolution to paresthesia of the upper limbs for three months. Associated with the condition, he has migraine without chronic aura and RMSD. The neurological examination showed Mini-Mental State Examination 22/30 (expected score of 29), list of animals in one minute: 09 animals; list of words starting with “F”: 03 words; clock test: 2/4; difficulty with calculations and digital agnosia with right/left apraxia; Upper limbs: eutrophic, FMG 4/5, bilateral distal; FMG 5/5 bilateral proximal; Lower limbs: eutrophic, bilateral FMG 4/5 distal and proximal with positive Mingazini; atypical gait with evidenced weakness in heel, toe and tandem gait; Bilateral dysdiadochokinesia with eumetric, slowed indexindex; ROT 4+/4+ in the right side with positive Hoffman and Babinski signs. MRI Brain (17/09/2020): extensive area of hypersignal on T2 and FLAIR (T2- weighted-Fluid-Attenuated Inversion Recovery) involving the periventricular white matter in all lobes without atrophic or expansive effect; Case 03: woman, 45 years old, started behavioral arrest epileptic seizures at the age of thirty-two, progressing to focal dysperceptive seizures with progression to bilateral tonic clonic seizures after eight months and multiple episodes of anterograde amnesia, presenting forgetfulness related to everyday work activities (exchanged worksheets , payments, calculation errors and budgets); associated with the condition presented migraine without chronic aura and RMSD. Genetic Test (04/06/2017): Heterozygous alteration in exon 8 of the NOTHC – 3 gene. Discussion: CADASIL presents a rare cause of cognitive decline and is often overlooked in diagnosis, except in cases of high clinical suspicion in a familial course. Access to imaging tests becomes fundamental for the diagnostic segment and the primordial genetic test for etiological elucidation and family planning, in the report described the family presentation with the same course of satellite symptoms (migraine without aura, and RMSD) associated with cognitive alteration with anticipation of age of onset are hallmarks of clinical thinking. Cases described in the literature show that the clinical symptomatology is not necessarily related to the level of brain injury observed in the imaging exam, which could be explained by personal factors and which exon is affected. The NOTCH-3 gene has 24 exons, in which the literature reports exon 4 as the most common mutation, followed by 3, 5 and 6, mainly in the Caucasian population. In an Asian population, the most affected exon is 4 and 11, which is also found in Italian descendants. The mutation in exon 8, described in the clinical case, is found in a population of Portuguese origin, being the second most common mutation in this nationality, behind the mutation in exon 4. Brain MRI studies have tried to elucidate the most affected brain regions, aiming to trace a line of evolution. Involvement of the temporal lobe, external capsule and corpus callosum are described as probable markers of CADASIL, and can be used as an aid in the diagnosis due to its specificity of 86% and sensitivity of 89%. Studies also show that the frontoparietal area has frequent findings of hyperintensity (100%), followed by the temporal lobe (83%), less frequently affecting the brainstem, occipital lobe and cerebellum. Despite the great advances in the specialized literature, the causes of the important cognitive dysfunction presented in the course of the evolution of CADASIL remain unclear. However, studies have suggested that the process of cognitive decline is more related to the loss of cortico-subcortical connections than to brain atrophy itself, with these disconnections resulting from repeated transient ischemic accidents. Science has been looking for ways to change the prognosis of CADASIL, recent studies in gene therapy and neurogenetics show the importance of thinking about this pathology as a genetic disease of great importance to change the prognosis of this pathology.

Sabe-se que a Modelagem da Informação da Construção (BIM), pode ser descrita pelo conjunto de tecnologias ou processos integrados que permitem a criação, a utilização e a atualização de modelos digitais de uma construção, de modo colaborativo, de forma a servir a todos os participantes do empreendimento, durante todo o ciclo de vida da construção (Brasil. Decreto nº 9.983, de 22 de agosto de 2019). Assim, essa tecnologia representa um avanço significativo no modo de execução de uma obra, visto que ela tende a desempenhar papéis importantes que vão desde a etapa anterior ao início da obra, quanto a etapa posterior à sua finalização (Eastman et al., 2014). Desta maneira, além da de proporcionar uma melhor visualização dos projetos, é possível a sua compatibilização, a partir da união de diferentes disciplinas aplicadas nos projetos, de forma a oportunizar um melhor gerenciamento de atividades e controle de processos. De certa forma, a versatilidade dos modelos BIM, fornece um ideal futuro de construções inteligentes, visto que promovem a agilidade nos processos de manutenção, a redução de custos e a diminuição de tempo nos serviços em suas diversas fases, seja em seu período de operação ou de usabilidade (Jaskulski, 2018 apud Ghaffarianhosinia et al., 2017). Entretanto, mesmo com a adoção de políticas governamentais, como é o caso do Decreto nº 9.377, que visa incentivar o uso dessa tecnologia no Brasil, existem entraves que cerceiam a sua adoção, visto que, segundo dados de uma pesquisa do Instituto Brasileiro de Economia (IBRE) da Fundação Getúlio Vargas (FGV), obtidos em 2018, apenas 7,5% das empresas utilizam BIM na área da construção civil. Assim, surgem diversas hipóteses que tendem a identificar possíveis motivações para a falta de utilização, como o conservadorismo em relação a plataformas anteriores, a falta de capacitação profissional e o aumento nas despesas (Araujo, 2019). Desta maneira, a falta de qualificação de profissionais especializados nessa área pode estar atrelada com a baixa implementação do BIM nas universidades, já que é notório a utilização de ferramentas mais antigas na matriz curricular, como o uso do software Autodesk AutoCad e Sketchup, nas disciplinas dos cursos de graduação. Desta maneira, visando os cenários que permeiam esta temática, este trabalho teve como objetivo analisar quantitativamente a inserção de cursos acerca da metodologia BIM na atividade “Semana de Capacitação” no contexto dos cursos dos discentes participantes da atividade, de forma a ponderar sobre a importância da utilização da metodologia BIM no ensino da graduação e dos cursos técnicos. Neste ínterim, durante a atividade implementada pelo Programa de Educação Tutorial PAESPE, do Campus A. C. Simões da Universidade Federal de Alagoas (UFAL), intitulada “Semana de Capacitação”, realizada em novembro do ano de 2022, foi proposta a realização de cursos voltados ao ensino de softwares que utilizam o BIM na graduação e no ensino técnico, de forma a englobar inscritos dos cursos de graduação em Arquitetura e Urbanismo, Engenharia Civil, Engenharia de Produção, Engenharia Química e do Curso Técnico em Edificações. Assim, dentre os minicursos ofertados no evento, os que estão associados à metodologia BIM foram: Render em Revit, Orçamento de Obras e BIM 5D e Revit Arquitetônico, de forma a englobar as fases do ciclo de vida de projeto e planejamento, apresentando uma abordagem teórico-prática da metodologia BIM. Neste sentido, os cursos tiveram carga horária de 03 (três) à 04 (quatro) horas e abordaram as disciplinas de arquitetura, design de interiores e orçamento, sendo utilizado o software Autodesk Revit para a modelagem arquitetônica, renderização e para a obtenção dos quantitativos de orçamentos. Com a implementação da atividade, obteve-se um total de 30 (trinta) inscritos nos cursos, sendo os de Revit Arquitetônico e Orçamento de Obras e BIM 5D os de maior quantidade de participantes, cada um com treze (13) alunos. Logo em seguida, o curso de Render em Revit, com quatro alunos. Esses participantes foram oriundos de diversas instituições de ensino de Alagoas, dentre as quais: UFAL, Instituto Federal de Alagoas (IFAL), SESI/SENAI, Universidade Maurício de Nassau (UNINASSAU) e Faculdade Figueiredo Costa (UNIFAL). Assim, foi notória a baixa participação de inscritos de cursos oriundos de instituições externas. Este fato pode ter acontecido devido à falta de divulgação presencial nestas instituições. Além disso, observou-se uma baixa participação de discentes no curso de Render em Revit. Isto pode ter ocorrido devido ao fato que houve uma baixa participação de alunos do curso de Arquitetura e Urbanismo, já que esta temática do BIM tem maior abrangência no curso supracitado. Ademais, é notório que a atividade pôde levar os conhecimentos acerca da metodologia BIM para discentes de diferentes instituições de ensino e cursos de graduação e de nível técnico. Desta maneira a possibilitar o contato dos discentes participantes com a metodologia BIM, a oportunizar a difusão da metodologia em diversas instituições superiores e técnicas e a propiciar o avanço da construção civil através da formação de profissionais capacitados.

Статья посвящена изучению фармакологической коррекции прооксидантных эффектов типичного нейролептика галоперидола с помощью верапамила, пирацетама и мексидола. Опыты проводились на белых беспородных крысах обоего пола массой 190-210г. Верапамил (25 мг/кг), пирацетам (200 мг/кг) и мексидол (200мг/кг) вводили внутрибрюшинно за 30 мин до внутрибрюшинной инъекции галоперидола (0,5 мг/кг). Для изучения корректорного действия комбинированно применяемых препаратов, после их введения, спустя 4 часа забивали животных путем декапитации в период между 12 и 14 часами при температуре помещения 22±1 ОС. На льду быстро извлекали мозг и выделяли фронтальную кору, стриатум и гипоталамус. Затем выделенные структуры размельчали в гомогенизаторе и определяли содержание диеновых конюгатов (ДК), гидроперекиси липидов (ГП), малонового диальдегида (МДА) колориметрическим методом, активности ферментов антиоксидантной системы супероксиддисмутазы (СОД), каталазы, глутатионпероксидазы ензиматическим методом и восстановленного глутатиона (GSH) колориметрическим методом. Результаты проведенных исследований еще раз доказали, что галоперидол в дозе 0,5 мг/кг обладает прооксидантным действием, усиливая процессы ПОЛ по сравнению с контрольными группами повышал содержание ДК, ГП и МДА в гипоталамусе, фронтальной коре и стриатуме. Усиление процессов ПОЛ по сравнению с контрольной группой привело к конпенсаторному повышению активности ферментов системы антиоксидантной защиты. Для коррекции побочного прооксидантного эффекта 0,5 мг/кг галоперидола, комбинированно применяемые верапамил 25 мг/кг, пирацетам 200 мг/кг и мексидол 200 мг/кг показали себя в роли мощного корректора и блокировали прооксидантный эффект галоперидола. Определение продуктов ПОЛ и активности антиоксидантной системы организма в трех структурах головного мозга показало, что комбинированно применяемые верапамил, пирацетам и мексидол предотвращали прооксидантный эффект галоперидола.

The median age at first marriage in the United States has increased steadily since the mid-20th century. In the mid-1950s, the median age was at a record low of just over 20 for women and 22 for men, but by 2020, the median age was 28 for women and 30 for men (see Figure 1). The median age at first marriage has increased similarly for both men and women. Consequently, the gender gap in the median age at first marriage has persisted, fluctuating between 1.6 and 2.7 years. This profile uses data from the 2019 American Community Survey (ACS), 1-year estimates to track the trends in women’s and men’s median ages at first marriage. The ACS is ideal because it provides the best annual data on marital status and demographic characteristics allowing for direct estimation of the median age at first marriage (Simmons & Dye, 2004). This is an update to our previous profiles on the topic for the years 2017 (FP-19-06), 2014 (FP-16-07), 2013 (FP-15-05), 2010 (FP-12-07), and 2008 (FP-09-03).