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Journal articles on the topic '1-2-4-triazole analysis'

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Published: 3 June 2025

Last updated: 31 July 2025

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1

Karpun, Yevhen, Volodymyr Parchenko, Tetiana Fotina, et al. "The investigation of antimicrobial activity of some s-substituted bis-1,2,4-triazole-3-thiones." Pharmacia 68, no. (4) (2021): 797–804. https://doi.org/10.3897/pharmacia.68.e65761.

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New S-substituted 4-alkyl-5-((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1,2,4-triazole-3-thiol derivatives have been designed, synthesized and studied their antimicrobial activity on 11 standard Gram-positive and Gram-negative microorganism strains. Their spectral and physicochemical parameters were established using modern comprehensive methods of analysis, including <sup>1</sup>H NMR spectroscopy, GC-MS and elemental analysis.It has been found that compound 2a exhibits strong suppression of 5 test strains (MBC = 15.6 µg/mL). Compound 4a showed moderate inhibition of Salmonella

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2

Arfa, Parween, and Naskar Subhendu. "Synthesis and characterization of 1,2,4-triazole containing Schiff base ligands and their CuII complexes." Journal of Indian Chemical Society Vol. 94, Feb 2017 (2017): 135–40. https://doi.org/10.5281/zenodo.5599195.

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Department of Chemistry, Birla Institute of Technology, Mesra, Ranchi-835 215, Jharkhand, India <em>E-mail</em> : subnaskar@yahoo.co.in Fax : 91-651-2275401 <em>Manuscript received online 24 March 2016, accepted 17 October 2016</em> The condensation of 4-amino-1,2,4-triazole with 4-(diethylamino)salicylaldeyde, 5-Br-salicylaldeyde and 2- hydroxy-4-methoxybenzaldehyde in methanol to produce 1,2,4-triazole containing Schiff base ligands 2-((4<em>H</em>-1,2,4-triazole4-ylimino)methyl)-5-(diethylamino)phenol (L<sup>1</sup>H), 2-((4<em>H</em>-1,2,4-triazole-4-ylimino)methyl)-4-bromophenol (L<sup>2<

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3

Suhak, O. A., О. I. Panasenko, and Ye G. Knysh. "Synthesis, physic and chemical properties of 2-(4-R-5-(thiophene-2-ylmethyl)-4h-1,2,4-triazole-3-ylthio)acetate acids and their salts." Farmatsevtychnyi zhurnal, no. 2 (August 14, 2018): 48–54. http://dx.doi.org/10.32352/0367-3057.2.17.06.

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Derivatives of 1,2,4-triazole are inherent in various types of biological activity. They can be used as pesticide and medicinal drugs (anticonvulsants, analgetics, antitumor and antibacterial). In this regard the search of new methods of synthesis and investigation of biological activity of 2-(4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-ylthio)acetate acids and their salts is relevant nowadays. With the aim of finding the new biologically active compounds 2-(4-R-5-(thiophene-2-ylmethyl)-4H-1,2,4-triazole-3-ylthio)acetate acids and their salts are synthesized, where R is methyl, ethy

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4

Karpun, Ye O., S. O. Borsuk, L. I. Kucherenko, and V. V. Parchenko. "The study of the optical activity of some S-derivatives 4-R-5-((((3-(pyridin-4-yl)-1H-1,2,4-triazole-5-yl)thio)methyl)-4H-1, 2,4-triazole-3-thiols." Current issues in pharmacy and medicine: science and practice 15, no. 2 (2022): 128–32. http://dx.doi.org/10.14739/2409-2932.2022.2.255791.

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About half of the drugs currently produced are chiral compounds, and about 90 % of these compounds are sold as racemates, consisting of an equimolar mixture of two enantiomers. Although they have the same chemical structure, most of the optical isomers of chiral substances show marked differences in biological activity. It is known that the presence of a single asymmetric atom has become almost an integral part of advanced drug design. The aim of this work was to determine the angle of rotation of the polarization plane of solutions of some S-derivatives of 4-R-5-((((3-(pyridin-4-yl)-1H-1,2,4-

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5

Safonov, A. A. "Study acute toxicity of 4-(R-amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiol in vivo." Farmatsevtychnyi zhurnal, no. 2 (August 14, 2018): 98–101. http://dx.doi.org/10.32352/0367-3057.2.16.06.

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Typically, the system is already known are used as the core for a new substance, which have already proved themselves as potential drugs. So one of these is 1,2,4-triazole ring. The purpose was to study acute toxicity of 4-((R-iden)amino)-5-(thiophen-2-ylmethyl)-4H-1,2,4-triazole-3-thiols and identify possible patterns acute toxicity of the chemical structure of indicators derivatives. In the study of acute contact toxicity was used spreadsheet rapid method for Prozorovsky V. B. Analysis of the results of studies acute toxicity of 1,2,4-triazole derivatives showed that all substanc

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6

Zdanovskaia, Maria A., Peter R. Franke, Brian J. Esselman, et al. "Vibrationally excited states of 1H- and 2H-1,2,3-triazole isotopologues analyzed by millimeter-wave and high-resolution infrared spectroscopy with approximate state-specific quartic distortion constants." Journal of Chemical Physics 158, no. 4 (2023): 044301. http://dx.doi.org/10.1063/5.0137340.

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In this work, we present the spectral analysis of 1 H- and 2 H-1,2,3-triazole vibrationally excited states alongside provisional and practical computational predictions of the excited-state quartic centrifugal distortion constants. The low-energy fundamental vibrational states of 1 H-1,2,3-triazole and five of its deuteriated isotopologues ([1-2H]-, [4-2H]-, [5-2H]-, [4,5-2H]-, and [1,4,5-2H]-1 H-1,2,3-triazole), as well as those of 2 H-1,2,3-triazole and five of its deuteriated isotopologues ([2-2H]-, [4-2H]-, [2,4-2H]-, [4,5-2H]-, and [2,4,5-2H]-2 H-1,2,3-triazole), are studied using millime

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7

Singh, Kiran, and Dharam Pal. "Synthetic, structural and biological studies of organosilicon(IV) complexes of Schiff bases derived from pyrrole-2-carboxaldehyde." Journal of the Serbian Chemical Society 75, no. 7 (2010): 917–27. http://dx.doi.org/10.2298/jsc081216063s.

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Selected new organosilicon(IV) complexes having the general formula R2SiCl[L] and R2Si[L]2 were synthesized by the reactions of Me2SiCl2 with Schiff bases [5-mercapto-4-(2-pyrrolecarboxalideneamino)-s-triazole, 5-mercapto-3-methyl-4-(2-pyrrolecarboxalidene amino)-s-triazole and 3-ethyl-5-mercapto-4-(2-pyrrolecarboxalideneamino)-s-triazole] in 1:1 and 1:2 molar ratios. All of the compounds were characterized by elemental analysis, molar conductance, and IR, UV, 1H-, 13C- and metal-NMR spectral studies. All the spectral data suggest an involvement with an azomethine nitrogen in coordination to t

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8

Md, Akram* Abdul Sayeed Mohd Waseem Akram MD Ather Ali Soherwardi. "STUDIES ON THE SYNTHESIS OF SOME NEW 1,2,4- TRIAZOLES DERIVATIVES AND EVALUATION FOR THEIR ANTI-FUNGAL ACTIVITY PROFILES." Indo American Journal of Pharmaceutical Sciences 04, no. 08 (2017): 2234–48. https://doi.org/10.5281/zenodo.839545.

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The synthesis of new heterocyclic compounds has always drawn the attention of medicinal chemist over the years mainly because they possess diverse biological properties. The literature survey on 1,2,4-triazoles revealed that they are endowed with wide variety of biological activities .During the present investigation a series of new 1,2,4-triazole derivatives N-(3-(2-(3- hydrazinyl-3-oxoalkanoyl)hydrazinyl)-5-(phenoxymethyl)-4H-1,2,4-triazol-4-yl)isonicotinamide(6a- 6e)were synthesized by reacting withN-(5-mercapto-3-(phenoxymethyl)-4H-1,2,4-triazol-4- yl)isonicotinamide (5) and aliphatic dica

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9

Neelgundmath, Mahabaleshwaraiah, and Oblennavar Kotresh. "Synthesis, Evaluation and Characterization of Some 1,3,4-Triazole-2-one Derivatives as Antimicrobial Agents." E-Journal of Chemistry 9, no. 4 (2012): 2407–14. http://dx.doi.org/10.1155/2012/672125.

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A series of novel compounds like 3[(phenyl substituted)-5-methyl-1(Benzosulphonylamine)]-1,3,4-triazole-2-ones II(a-f) were synthesized by treating 4-amino-1-phenyl-3-methyl-5-oxo-1,2,4-triazoles with benzene sulphonyl chloride using pyridine as solvent. Similarly by using 4-amino-1-aryl-3-methyl-5-oxo-1,2,4-triazoles and acetic anhydride as starting material 3[(phenyl substituted)-5-methyl-1(acetylamino)]-1,3,4-triazole-2-ones III(a-f) were synthesized and also 3[(phenyl substituted)-5-methyl-1(chloroacetyl)]-1,3,4-triazole-2-ones I(a-f) were synthesized by treating 4-amino-1-aryl-3-methyl-5-

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10

Hajib, Sara, Younas Aouine, Hassane Faraj, and Anouar Alami. "N-(1-azido-2-(azidomethyl)butan-2-yl)-4-methylbenzenesulfonamide." Molbank 2022, no. 3 (2022): M1448. http://dx.doi.org/10.3390/m1448.

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A new bi-triazole precursor, N-(1-azido-2-(azidomethyl)butan-2-yl)-4-methylbenzenesulfonamide, was synthesized in two steps from 2-amino-2-ethyl-1,3-propanediol, with an overall yield of 80%. The chemical structures of the products obtained were established based on 1D and 2D NMR, IR spectroscopy, and elemental analysis.

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11

Wakale, V. S., S. R. Pattan, V. B. Gawali, and R. Kabargande. "SYNTHESIS, CHARACTERIZATION AND PHARMACOLOGICAL EVALUATION OF SUBSTITUTED 1, 2, 4-TRIAZOLE DERIVATIVES." INDIAN DRUGS 53, no. 03 (2016): 11–16. http://dx.doi.org/10.53879/id.53.03.10444.

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A series of 2-(4-substituted)-5-mercapto-4H-1,2,4-triazol-3-yl)phenols (3a-3f) and 3-(3-(2-hydroxyphenyl)5-mercapto-4H-1,2,4-triazol-4-yl)-2-substituted thiazolidin-4-ones (4a-4f) were designed and synthesized. The synthesized compounds were characterized by IR, 1h-NmR and elemental analysis. The synthesized compounds were evaluated for analgesic and anti-inflammatory activity. Among the tested compounds, compounds 3b and 4e showed potent analgesic activity and compounds 3b and 3e have shown promising anti-inflammatory activity.

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12

Nurhan G mr k o lu, Nurhan G. mr k. o. lu, and Muhammad Imran and Inam Iqbal Muhammad Imran and Inam Iqbal. "Synthesıs and Characterızatıon of New Trıazole and Coumarın-Derived Heterocyclıc Compounds Part I." Journal of the chemical society of pakistan 41, no. 6 (2019): 1097. http://dx.doi.org/10.52568/000830/jcsp/41.06.2019.

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Synthesis of ethyl ester of acetic acid containing 5-oxo-[1,2,4] triazole ring (2) was achieved by the condensation of 3-substituted-4-amino-1H-1,2,4-triazol-5(4H)-one (1) with ethyl bromoacetate in basic medium. Compound 2, was then further reacted with hydrazine hydrate to form acid hydrazide, which is 2-(4-amino-3-substituted-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)acetohydrazide (3). Compound 3 was later treated with three different diverse coumarin aldehydes (6, 12, 18) resulted in the formation of arylidene hydrazides as cis–trans conformers (7, 8, 13, 14, 19, 20). In conclusion, we synt

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13

Dobosz, Maria, Monika Pitucha, Izabela Dybala, and Anna E. Kozioł. "Cyclization of Semicarbazide Derivatives of 3-Methyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazole-4-acetic Acid." Collection of Czechoslovak Chemical Communications 68, no. 4 (2003): 792–800. http://dx.doi.org/10.1135/cccc20030792.

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By the reaction of hydrazide of 3-methyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazole-4-acetic acid (1) with isocyanates, 3-methyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazole-4-acetosemicarbazide derivatives 2 were obtained. Cyclization of these compounds in the presence of 2% NaOH led to the formation of 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives 3, which was confirmed by X-ray analysis of 3b.

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14

Bai, Shi-Qiang, Lu Jiang, David James Young, and T. S. Andy Hor. "Hybrid 1,2,3-Triazole Supported CuII Complexes: Tuning Assembly and Weak Interaction-Driven Crystal Growth." Australian Journal of Chemistry 69, no. 4 (2016): 372. http://dx.doi.org/10.1071/ch15650.

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Two new dinuclear CuII complexes [Cu2Cl4(L1)2] (1) and [Cu2Cl4(L2)2] (2) (L1 = 2-((4-(2-(cyclopentylthio)ethyl)-1H-1,2,3-triazol-1-yl)methyl)pyridine; L2 = 2-((4-(pyridin-2-yl)-1H-1,2,3-triazol-1-yl)methyl)benzonitrile) were synthesised and characterised by single-crystal X-ray diffraction (XRD), powder XRD, thermogravimetric analysis, elemental analysis and IR measurements. The picolyl-triazole ligand L1 coordinates in a chelate-bridging mode forming a dinuclear structure 1. The more rigid pyridyl-triazole ligand L2 chelates only, generating a chloride-bridged dinuclear complex 2. Both crysta

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15

Liu, Feng-Yi, Dong-Mei Zhou, Xiao-Lan Zhao, and Jun-Feng Kou. "Synthesis, crystal structures and luminescence properties of seven mononuclear zinc(II), cadmium(II), cobalt(II) and nickel(II) complexes with 5-(4-methylphenyl)-3-(pyridin-2-yl)-1H-1,2,4-triazole." Acta Crystallographica Section C Structural Chemistry 73, no. 5 (2017): 382–92. http://dx.doi.org/10.1107/s2053229617004697.

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Due to their versatile coordination modes and metal-binding conformations, triazolyl ligands can provide a wide range of possibilities for the construction of supramolecular structures. Seven mononuclear transition metal complexes with different structural forms, namely aquabis[3-(4-methylphenyl)-5-(pyridin-2-yl)-1H-1,2,4-triazolato-κ2 N 1,N 5]zinc(II), [Zn(C14H11N4)2(H2O)], (I), bis[5-(4-methylphenyl)-3-(pyridin-2-yl)-1H-1,2,4-triazole-κ2 N 3,N 4]bis(nitrato-κO)zinc(II), [Zn(NO3)2(C14H12N4)2], (II), bis(methanol-κO)bis[3-(4-methylphenyl)-5-(pyridin-2-yl)-1H-1,2,4-triazolato-κ2 N 1,N 5]zinc(II

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16

Miao, Li, Xu, Deng, and Ji. "A Three-Dimensional Cadmium(II) Coordination Network Based on 1,3-Di-(1,2,4-triazole-4-yl)benzene: Synthesis, Structure, and Luminescence Properties." Crystals 9, no. 11 (2019): 592. http://dx.doi.org/10.3390/cryst9110592.

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1,2,4-Triazole and its derivatives have been investigated extensively in the construction of coordination polymers. Using a 1,2,4-triazole ligand 1,3-di-(1,2,4-triazole-4-yl)benzene (dtb), a new three-dimensional coordination polymer, {[Cd2(dtb)2(SO4)(H2O)]·(1,2-H2bdc)·SO4}n (1) (1,2-H2bdc = 1,2-benzenedicarboxylic acid), was synthesized under solvothermal conditions. Single-crystal X-ray diffraction analysis revealed that there are two crystallographically different Cd(II) ions in 1 with distorted pentagonal bipyramidal [CdN4O3] geometry and distorted octahedral [CdN4O2] geometry, respectivel

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17

Vorga, Milenca Mariana, and Valentin Badea. "(±)-2-{[4-(4-Bromophenyl)-5-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}-1-phenyl-1-ethanol." Molbank 2021, no. 3 (2021): M1268. http://dx.doi.org/10.3390/m1268.

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The novel racemic secondary alcohol (±)-2-{[4-(4-bromophenyl)-5-phenyl-4H-1,2,4-triazol-3-yl]sulfanyl}-1-phenyl-1-ethanol (12) has been successfully synthesized through S-alkylation of 4-(4-bromophenyl)-5-phenyl-4H-1,2,4-triazole-3-thiol (10) in alkaline medium with 2-bromo-1-phenylethanone followed by reduction of the corresponding ketone 11. All the synthesized compounds were characterized by IR, 1D (1H, 13C, DEPT135) and 2D (1H-1H, 1H-13C and 1H-15N) NMR spectroscopy, elemental analysis and HRMS spectrometry.

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18

Wang, Yi, N. R. Bulatova, E. E. Klen, et al. "Efficacy of 4-(2-(4-nitrophenyl)-2-oxoethyl)-1-(thietane-3-yl)-1h-1,2,4-triazol-4 bromide in the rat model of inferior vena cava thrombosis." Translational Medicine 11, no. 1 (2024): 19–27. http://dx.doi.org/10.18705/2311-4495-2024-11-1-19-27.

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Introduction. According to WHO, acute disorders of cerebral circulation are anticipated to become a predominant contributor to the global disease burden by 2030. The comprehensive management of vascular depression entails not only the use of antidepressants but also fundamental interventions. The development of a novel molecule based on thietane-containing heterocycles, merging the attributes of an antidepressant and an antiplatelet agent, holds promise for enhancing therapeutic efficacy in patients with acute cerebrovascular accidents through multimodal action. Objective is to conduct a precl

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19

(Miss), Megha K. Burghate, K. Burghate S., and N. Berad B. "Synthesis of novel bis-1,3,4-thiadiazoles, bis-1,2,4-triazoles and their antimicrobial activity." Journal of Indian Chemical Society Vol. 85, May 2008 (2008): 561–65. https://doi.org/10.5281/zenodo.5816535.

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P. G. Department of Chemistry, Shri Shivaji Science College, Amravati-444 603, Maharashtra, India <em>E-mail :</em> meghaburghate@rediffmail.com <em>Manuscript received 12 February 2007, revised 7 January 2008, accepted 6 March 2008</em> Condensation of sehacic acid dihydrazide (1) with aryl/alkyl isothiocyanates (2a-g) gives bis-(<em>N</em>-aryl/alkylthiocarbamido)-sebacic acid diamidcs (3a-g), which on reaction with <em>o</em>-phosphoric acid yields 1 ,8-bis-(2-aryl/alkylamino1,3,4-thiadiazol-5-yl)-octanes (4a-g). 1,8-Bis-(3-mcrcapto-4-aryl/alkyl-1,2,4-triazol-5-yl)-octanes (5a-g) were obtai

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20

Zaki, Khadija, Abdelouahid Sbai, Mohammed Bouachrine, and Tahar Lakhlifi. "Regioselectivity study of 1,3-dipolar cycloaddition of 2-azido-N-(4-diazenylphenyl)acetamide with terminal alkyne through DFT analysis." Current Chemistry Letters 14, no. 1 (2025): 183–92. http://dx.doi.org/10.5267/j.ccl.2024.7.001.

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The mechanism and regioselectivity of 1,3-dipolar reaction of 2-azido-N-(4-diazenylphenyl) acetamide and an alkyne have been studied in gas phase and in DMSO using the B3LYP-GD3 functional and 6-31G(d,p) basis set. The reaction followed a one-step mechanism with asynchronous TSs. The calculated global reactivity indices calculated revealed, among other things, the nucleophile character of the 2-azido-N-(4-diazenylphenyl)acetamide and the electrophile character of the alkyne (4-bromo-2-chloro-1-ethynylbenzene), in addition to an electron transfer from the 4-bromo-2-chloro-1-ethynylbenzene towar

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21

Afzaletdinova, Nasima G. "Research extraction of bismuth (III) by the derivative 0f 1,2,4 triazole from hydrochloric acid solutions." Вестник Пермского университета. Серия «Химия» = Bulletin of Perm University. CHEMISTRY 12, no. 2 (2022): 88–98. http://dx.doi.org/10.17072/2223-1838-2022-2-88-98.

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Studied the extraction of bismuth (III from 1.0 mol / l) hydrochloric acid with 1,2,4 triazole derivatives: (1- [2- (2,4-dichlorophenyl) -4-propyl-1 , 3-dioxolan-2-yl] -1H-1,2,4 triazole. Optimum extraction conditions have been found. It has been found that bismuth (III) is extracted by the anion exchange mechanism at a contact time of 5 min. Chlorocomplex of bismuth (III) is isolated and characterized by electron and IR spectroscopy and elemental analysis. Reextraction of bismuth (III) from 1.0 mol / l solution of hydrochloric acid were studied.

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Li, Fang-Yao, Lin Huang, Qian Li, et al. "Synthesis and Antiproliferative Evaluation of Novel Hybrids of Dehydroabietic Acid Bearing 1,2,3-Triazole Moiety." Molecules 24, no. 22 (2019): 4191. http://dx.doi.org/10.3390/molecules24224191.

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To discover novel potent cytotoxic diterpenoids, a series of hybrids of dehydroabietic acid containing 1,2,3-triazole moiety were designed and synthesized. The target compounds were characterized by means of FT-IR, 1H NMR, 13C NMR, ESI-MS and elemental analysis techniques. The in vitro cytotoxicity of these compounds was evaluated by standard MTT (methyl thiazolytetrazolium) assay against CNE-2 (nasopharynx), HepG2 (liver), HeLa (epithelial cervical), BEL-7402 (liver) human carcinoma cell lines and human normal liver cell (HL-7702). The screening results revealed that most of the hybrids showe

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Toraskar, M. P. "Comparative, anti-infective screening and molecular docking studies of 4-amino-1, 2, 4-triazole derivatives." Journal of Medical Pharmaceutical and Allied Sciences 13, no. 5 (2024): 6744–51. http://dx.doi.org/10.55522/jmpas.v13i5.6677.

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The rise of drug-resistant bacteria is a problem in medicine. This highlights the need to find new molecules that have anti-infective properties. In this study, thiosemicarbazone derivatives were made using a 4-amino-1,2,4-triazole structure. We have evaluated at the anti-infective activity against E. coli, S. aureus, C. albicans, & M. tuberculosis. Among the compounds tested, 4g showed activity at concentrations of 1 μg/ml & 2 μg/ml against E. coli and S. aureus. The molecule 4c had anti-infective activity at a concentration of 6.25 μg/ml against M. tuberculosis. Four compounds had ni

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Yevgean, Pruglo. "Synthesis, physical and chemical properties and anxiolytic activity OF 2-(4-(R-arylidenamino)-5-methyl-4H-1,2,4-triazole-3-YL)thio)acetic acids and their salts." ScienceRise: Pharmaceutical Science, no. 3(13) (June 29, 2018): 19–25. https://doi.org/10.15587/2519-4852.2018.135786.

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It is estimated that 50% of all molecules of medicinal products used in drug therapy are administered as salts. This fact indicates that formation of a medicinal substance salt is an important stage in the development of a medicinal remedy. Therefore, we believe that the combinatorial synthesis of organic and inorganic salts of derivatives of 1,2,4-triazole has not only theoretical but also practical significance. <strong>The aim of the work </strong>is to synthesize and establish the structure of new 2-((4-(R-arylidenamino)-5-methyl-4H-1,2,4-triazole-3-yl)thio)acetic acids and their salt

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Wang, Qiao-Li, Hong Xu, Hong-Wei Hou, and Guang Yang. "Synthesis and Structures of Silver(I) Adducts with 4-Amino-4H-1,2,4-triazole." Zeitschrift für Naturforschung B 64, no. 10 (2009): 1143–46. http://dx.doi.org/10.1515/znb-2009-1006.

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Reactions of silver(I) salts with 4-amino-4H-1,2,4-triazole (4-NH2-tz) in a 1 : 1 molar ratio yield four new silver adducts, namely [Ag(4-NH2-tz)](CF3SO3) (1), [Ag(4-NH2-tz)1.75](ClO4) (2), [Ag(4- NH2-tz)1.75](BF4) (3) and [Ag(4-NH2-tz)1.75](NO3) (4). X-Ray analysis shows that 1 exhibits a 3D cationic [Ag(4-NH2-tz)]+ metal-organic framework of srs topology; 2, 3 and 4 are isostructural and display an infinite chain structure containing an Ag4tz6 cluster.

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Karpun, E. O., and V. V. Parchenko. "Synthesis, physicochemical properties and antigypoxic activity of some S-derivatives of 4-alkyl-5-(((3-(pyridin-4-yl)-1H-1,2,4-triazol-5-yl)thio)methyl)-4H-1,2,4-triazole-3-thiol." Farmatsevtychnyi zhurnal, no. 6 (December 9, 2020): 56–64. http://dx.doi.org/10.32352/0367-3057.6.20.06.

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Hypoxia is a discrepancy between the required energy of the cell in the mitochondrial oxidative phosphorylation system. The immediate cause of the deficiency is a decrease in the oxygen concentration in the mitochondria. Today there is a huge demand for the development of new anti-hypoxic drugs. t is known that 1,2,4-triazole compounds can have antimicrobial, anti-inflammatory, anti-hypoxic effects. Modification of the 1,2,4-triazole nucleus is a productive way to create original active molecules with a non-planar structure, for their binding to bio-target substrates. Derivatives of bis-1,2,4-

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Majed Jari Mohammed, Majed Jari Mohammed, Abdul Amir H. Kadhum Abdul Amir H Kadhum, and Adnan Ibrahim Mohammed and Sameer H. Abbood Al Rekabi Adnan Ibrahim Mohammed and Sameer H Abbood Al Rekabi. "Synthesis of One New Sugar Imine Molecule." Journal of the chemical society of pakistan 42, no. 1 (2020): 103. http://dx.doi.org/10.52568/000622.

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In this research, the molecule Nand#39;-((E)-5-methoxy-2-((1-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-4,5-dihydro-1H-1,2,3-triazol-4-yl)methoxy) benzylidene)-4-methyl-1,2,3-thiadiazole-5-carbohydrazide were synthesized and characterized by several conventional analysis methods. Its physical properties and thermal stability was studied. The synthesis was conducted based on D-glucose using concept of click chemistry reaction mechanism. Some of the reaction was conducted using microwave irradiation. The synthesis steps initiated by adding propargyl bromide to

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28

Majed Jari Mohammed, Majed Jari Mohammed, Abdul Amir H. Kadhum Abdul Amir H Kadhum, and Adnan Ibrahim Mohammed and Sameer H. Abbood Al Rekabi Adnan Ibrahim Mohammed and Sameer H Abbood Al Rekabi. "Synthesis of One New Sugar Imine Molecule." Journal of the chemical society of pakistan 42, no. 1 (2020): 103. http://dx.doi.org/10.52568/000622/jcsp/42.01.2020.

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In this research, the molecule Nand#39;-((E)-5-methoxy-2-((1-((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-4,5-dihydro-1H-1,2,3-triazol-4-yl)methoxy) benzylidene)-4-methyl-1,2,3-thiadiazole-5-carbohydrazide were synthesized and characterized by several conventional analysis methods. Its physical properties and thermal stability was studied. The synthesis was conducted based on D-glucose using concept of click chemistry reaction mechanism. Some of the reaction was conducted using microwave irradiation. The synthesis steps initiated by adding propargyl bromide to

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29

Maliszewska-Guz, Alicja, Monika Wujec, Monika Pitucha, et al. "Cyclization of 1-{[(4-Methyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetyl}thiosemicarbazides to 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives and Their Pharmacological Properties." Collection of Czechoslovak Chemical Communications 70, no. 1 (2005): 51–62. http://dx.doi.org/10.1135/cccc20050051.

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By the reaction of 4-methyl-4H-1,2,4-triazole-3-thiol with ethyl bromoacetate, ethyl [(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetate (1) was obtained. This compound was converted to [(4-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]acetohydrazide (2). In the reaction of 2 with isothiocyanates, new thiosemicarbazides 3a-3g were obtained. The cyclization of 3a-3g in 2% aqueous solution of sodium hydroxide led to the formation of 4H-1,2,4-triazole-3(2H)-thione derivatives 4a-4g, whereas the cyclization in acid media led to the formation of 2-amino-1,3,4-thiadiazole derivatives 5a-5g. Molecular structur

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30

Sheldrick, W. S., and P. Bell. "Interaction of Metal Ions with 7-Deaza-8-aza-and 8-Aza-purines Preparation and X-Ray Structural Analysis of Copper(II) Complexes." Zeitschrift für Naturforschung B 42, no. 2 (1987): 195–202. http://dx.doi.org/10.1515/znb-1987-0213.

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Abstract The reaction of 8-aza-and 7-deaza-8-aza-purines with Cu2+ cations in acid solution has been studied. At a pH value of 2, the 8-azaadenine complex [Cu(H2O)4(AAdH)2](NO3)2 (1), which displays Cu-N9 coordination, may be isolated from solution. The reaction of CuCl2 with 8-aza-hypoxanthine in concentrated HCl solution leads to ring opening at C2 of the azapurine with subsequent formation of dichlorobis[(5-amino-4-carboxamide)[1 - 3]triazole] copper(II) dihydrate 2, in which the triazole ligands display a chelating function, coordinating the metal via N7 and O6. The results for 1 and 2 sug

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31

Zhang, Jing, Lixue Zhang, Xinxiang Lei, Changfeng Zhou, Xiaodan Fu, and Haile Zhang. "Synthesis and Biological Activities of Some Schiff's Bases from 4-amino-3-(3-hydroxybutyl)-1H-1, 2, 4-triazole-5-thione." Journal of Chemical Research 2009, no. 4 (2009): 208–11. http://dx.doi.org/10.3184/030823409x435928.

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Sixteen novel Schiff's bases have been synthesised in high yields from 4-amino-3-(3-hydroxybutyl)-1 H-1, 2, 4-triazole-5-thione. All the newly synthesised compounds have been characterised by elemental analysis, IR, 1H NMR, 13C NMR and MS. Plant growth-regulating activity tests showed that most compounds have remarkable effects on the growth of wheat and radish at a mass concentration of 50μg mL−1.

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32

Wurfer, Flavius-Gabriel, and Valentin Badea. "(R,S)-2-{[4-(4-Methoxyphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl] thio}-1-phenyl-1-ethanol." Molbank 2021, no. 2 (2021): M1231. http://dx.doi.org/10.3390/m1231.

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4-(4-Methoxyphenyl)-5-phenyl--4H-1,2,4-triazole-3-thiol (4) was alkylated to 2-{[4-(-4-methoxyphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl]thio}-1-phenylethan-1-one (5) in alkaline conditions using 2-bromo-1-phenylethanone. The alkylated compound (5) was reduced at the carbonyl group to the corresponding racemic secondary alcohol with an asymmetric carbon, (R,S)-2-{[4-(4-methoxyphenyl)-5-phenyl-4H-1,2,4-triazol-3-yl]thio}-1-phenyl-1-ethanol (6). Both synthesized compounds, ketone (5) and secondary alcohol (6), are new and have not been reported yet in the literature. All the synthesized compounds we

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33

Pokhodylo, Nazariy T., Yurii Slyvka, and Volodymyr Pavlyuk. "Synthesis, crystal structure and Hirshfeld surface analysis of 5-cyclopropyl-N-(2-hydroxyethyl)-1-(4-methylphenyl)-1H-1,2,3-triazole-4-carboxamide." Acta Crystallographica Section E Crystallographic Communications 77, no. 10 (2021): 1043–47. http://dx.doi.org/10.1107/s2056989021009774.

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The title compound, C15H18N4O2, was obtained via a two-step synthesis (Dimroth reaction and amidation) for anticancer activity screening and was selected from a 1H-1,2,3-triazole-4-carboxamide library. The cyclopropyl ring is oriented almost perpendicular to the benzene ring [dihedral angle = 87.9 (1)°], while the dihedral angle between the mean plane of the cyclopropyl ring and that of the triazole ring is 55.6 (1)°. In the crystal, the molecules are linked by O—H...O and C—H...N interactions into infinite ribbons propagating in the [001] direction, which are interconnected by weak C—H...O in

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34

Odyntsova, V. M. "The main optical characteristics of UV-spectra of 5-(adamantane-1-yl)-4R-1,2,4-triazole-3-thiones derivatives." Farmatsevtychnyi zhurnal, no. 5 (September 4, 2018): 57–62. http://dx.doi.org/10.32352/0367-3057.5.15.01.

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The development of pharmaceutical chemistry confronts molecular spectroscopy the problem of calculating the electronic states, assumptions and explanations of the various properties of complex organic compounds. In recent years, following the basic optical characteristics of the electronic absorption spectra: the wave number of maximum absorption – νmax (in cm-1), the half-width of the absorption bands of – ∆ν1/2 (cm-1), the integral intensity of the absorption band (in l/mol·cm2), the oscillator strength of the electronic transition – f, the matrix element of the transition of electrons – Mik

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35

Hamada, Nagwa M. M., Sohila H. Mancy, and Mohamed A. El Sekily. "A Facile Synthesis, Spectroscopic Identification, and Antimicrobial Activities of Some New Heterocyclic Derivatives from D-erythro-2,3-hexodiuloso-1,4-lactone-2-(o-chlorophenyl hydrazone)-3-oxime." International Journal of Chemistry 16, no. 2 (2024): 62. http://dx.doi.org/10.5539/ijc.v16n2p62.

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A new series of different heterocyclic derivatives was prepared via a facile unimolecular condensation of D-iso ascorbic acid with o-chlorophenyl hydrazine to give D-erythro-2,3-hexodiulosono-1,4-lactone 2-( o-chlorophenyl hydrazine (2). Reactions of&nbsp;(2)&nbsp;with hydroxylamine gave the 2-( o-chlorophenyl hydrazone)-3-oxime (3). On boiling with boiling acetyl chloride,&nbsp;(3)&nbsp;gave 2-o-chlorophenyl-4-(2,3-di-O-acetyl-D-erythro-glyceryl-1-yl)-1,2,3-triazole-5-carboxylic acid-5,1́-lactone (4). In the treatment of (3) with benzoyl chloride in pyridine the same dehydrati

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36

Hamada, Nagwa M. M., Sohila H. Mancy, and Mohamed A. El Sekily. "A Facile Synthesis, Spectroscopic Identification, and Antimicrobial Activities of Some New Heterocyclic Derivatives from D-erythro-2,3-hexodiuloso-1,4-lactone-2-(o-chlorophenyl hydrazone)-3-oxime." International Journal of Chemistry 17, no. 2 (2025): 50. https://doi.org/10.5539/ijc.v17n2p50.

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A new series of different heterocyclic derivatives was prepared via a facile unimolecular condensation of D-iso ascorbic acid with o-chlorophenyl hydrazine to give D-erythro-2,3-hexodiulosono-1,4-lactone 2-( o-chlorophenyl hydrazine (2). Reactions of&nbsp;(2)&nbsp;with hydroxylamine gave the 2-( o-chlorophenyl hydrazone)-3-oxime (3). On boiling with boiling acetyl chloride,&nbsp;(3)&nbsp;gave 2-o-chlorophenyl-4-(2,3-di-O-acetyl-D-erythro-glyceryl-1-yl)-1,2,3-triazole-5-carboxylic acid-5,1́-lactone (4). In the treatment of (3) with benzoyl chloride in pyridine the same dehydrati

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37

Luo, Wei, Di Yao, Haiye Li, Fuping Huang, Qing Yu, and Hedong Bian. "Coordination Assemblies of CoII, NiII, ZnII, and CuII with 3,3′,4,4′-Biphenyltetracarboxylic Acid and Three Positional Isomeric Ligands." Australian Journal of Chemistry 66, no. 11 (2013): 1378. http://dx.doi.org/10.1071/ch13183.

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Eight different complexes with three positional isomeric dipyridyl ligands (3,3′-Hbpt, 3,4′-Hbpt, and 4,4′-Hbpt) (here, 3,3′-Hbpt = 1H-3,5-bis(3-pyridyl)-1,2,4-triazole, 3,4′-Hbpt = 1H-3-(3-pyridyl)-5-(4-pyridyl)-1,2,4-triazole, and 4,4′-Hbpt = 1H-3,5-bis(4-pyridyl)-1,2,4-triazole), as well as 3,3′,4,4′-biphenyltetracarboxylic acid (H4bptc), namely, {[M(bptc)0.5(3,3′-Hbpt)(H2O)2]·H2O}n (M = Co (1), M = Ni (2)), {[Zn2(bptc)(3,3′-Hbpt)2]·3H2O}n (3), [Co(bptc)0.5(3,4′-Hbpt)(H2O)]n (4), [Ni(bptc)0.5(3,4′-Hbpt)2(H2O)2]n (5), {[Cu(bptc)0.5(3,4′-Hbpt)(H2O)]·H2O}n (6), and {[M(bptc)0.5(4,4′-Hbpt)2(H2O

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38

Fall, Serigne Abdou Khadir, Sara Hajib, Oumaima Karai, et al. "Tetramethyl 1,1′-(2-[{4,5-bis(Methoxycarbonyl)-1H-1,2,3-triazol-1-yl}methyl]-2-[(4-methylphenyl)sulfonamido]propane-1,3-diyl)bis(1H-1,2,3-triazole-4,5-dicarboxylate)." Molbank 2021, no. 1 (2021): M1186. http://dx.doi.org/10.3390/m1186.

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A new compound tetramethyl 1,1′-(2-[{4,5-bis(methoxycarbonyl)-1H-1,2,3-triazol-1-yl}methyl]-2-[(4-methylphenyl)sulfonamido]propane-1,3-diyl)bis(1H-1,2,3-triazole-4,5-dicarboxylate) (3) was prepared in two steps starting from 2-((4-methylphenyl)sulfonamido)-2-((tosyloxy)methyl)propane-1,3-diylbis(4-methylbenzenesulfonate) (1), with an overall yield of 74%. The key step being the copper-free Huisgen cycloaddition between N-(1,3-diazido-2-(azidomethyl)propan-2-yl)-4-methylbenzenesulfonamide (2) and commercially available dimethyl acetylenedicarboxylate. The chemical structure of compound 3 was de

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39

He, Xiao-Xiao, and Ya-Mei Guo. "Two ZnIIcoordination complexes assembled by trithiocyanuric acid and two different N-donor auxiliary ligands." Acta Crystallographica Section C Structural Chemistry 70, no. 8 (2014): 764–69. http://dx.doi.org/10.1107/s2053229614014260.

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The dipyridyl-type building blocks 4-amino-3,5-bis(pyridin-3-yl)-1,2,4-triazole (3-bpt) and 4,4′-bipyridine (bpy) have been used to assemble with ZnIIin the presence of trithiocyanuric acid (ttcH3) to afford two coordination compounds, namely bis[4-amino-3,5-bis(pyridin-3-yl)-1,2,4-triazole-κN3]bis(trithiocyanurato-κ2N,S)zinc(II), [Zn(C3H2N3S3)2(C12H10N6)2]·2H2O, (1), andcatena-poly[[[bis(trithiocyanurato-κ2N,S)zinc(II)]-μ-4,4′-bipyridine-κ2N:N′] 4,4′-bipyridine monosolvate], {[Zn2(C3H2N3S3)4(C10H8N2)3]·C10H8N2}n, (2). Single-crystal X-ray analysis indicates that complex (1) is a mononuclear s

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40

Bader, Ali Taleb, Nada Ahmed Rasheed Al-qasii, Ahmed Hassen Shntaif, et al. "Synthesis, Structural Analysis and Thermal Behavior of New 1,2,4-Triazole Derivative and Its Transition Metal Complexes." Indonesian Journal of Chemistry 22, no. 1 (2021): 223. http://dx.doi.org/10.22146/ijc.68859.

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Cobalt(II), nickel(II), and copper(II) complexes containing bidentate ligands )5-(4-nitrophenyl)-4-((4-phenoxybenzylidene)amino)-4H-1,2,4-triazole-3-thiol) could be synthesized by the condensation reaction between 1,2,4-triazole derivative and p-phenoxy benzaldehyde. The ligand and its complexes were characterized by various spectroscopic techniques such as FTIR, UV-visible, 1H and 13C-NMR, element analysis, molar conductance, and magnetic susceptibility test. The new ligand was exploited as a ligand to coordinate with Co(II), Ni(II), and Cu(II) by a molar ratio of 1:2 (metal:ligand). The prep

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41

Kucherenko, L. I., T. S. Brytanova, and A. S. Hotsulia. "In silico study of properties in the series of 1-alkyl-4-(((5-nitrofuran-2-yl)methylene)amino)- 1,2,4-triazole halides." Current issues in pharmacy and medicine: science and practice 17, no. 1 (2024): 10–16. http://dx.doi.org/10.14739/2409-2932.2024.1.297734.

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1,2,4-Triazole derivatives open up wide horizons for modern medicinal chemists to develop innovative drugs. The use of 1,2,4-triazole derivatives in pharmacological research is based on their ability to produce an effective effect on biological systems and interact with molecular targets. These azoles can be used to regulate various physiological processes, which opens up the possibility of their effective use in the treatment of various diseases. Targeted modification of the structure of 1,2,4-triazole derivatives opens up wide opportunities for the creation of biologically active compounds w

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42

Natalia, Chalenko, Demchenko Anatoly, and Syrova Ganna. "Synthesis of potential antiexudative preparations for 2-((4-amino-5-(furan-2-il)-1,2,4-triazole-(4H)-3-yl)-sulfanyl)-N-acetamide series." ScienceRise: Pharmaceutical Science, no. 3(19) (June 28, 2019): 22–29. https://doi.org/10.15587/2519-4852.2019.171878.

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<strong>Aim.</strong> Conduct the purposeful synthesis of new potential biologically active substances of derivatives of 2 - ((4-amino-5- (furan-2-yl) -1,2,4-triazol (4H) -3-yl) -sulfanyl) -N-acetamides and evaluate their anti-exudative activity on the model of formalin edema in rats. <strong>Materials and methods.</strong> In this work, standard methods of organic synthesis, physical and chemical methods of proofing the structure of synthesized compounds, elemental analysis, <sup>1</sup>H NMR spectroscopy, chromatographic mass spectrometry, and antiexudative activity were studi

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43

Natheil, Amal Hussein. "Synthesis and Characterization New 1, 2, 4-Triazole Derivative and Its Complexes with Some Transition Metal Ions." European Journal of Theoretical and Applied Sciences 2, no. 5 (2024): 579–84. http://dx.doi.org/10.59324/ejtas.2024.2(5).55.

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An innovative class of ligand compounds using The ions of transition metals (Cr(III), Fe(III), and Ni(II)).The ligand N,N'-(4H-1,2,4-triazole-3,5-diyl)bis(4-methoxybenzamide) was produced by reacting 2,5-di amino-1,2,4-triazole with two moles of methyl 4-methoxybenzoate in the presence of ethanol and a few drops of glacial acetic acid. The recently produced chemicals were studied using a battery of analytical tools, analysis of elements (C, H, and N), nuclear magnetic resonance spectroscopy, Fourier transform infrared spectroscopy, mass spectrometry, and atomic absorption are some of the techn

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44

Amal, Hussein Natheil. "Synthesis and Characterization New 1, 2, 4-Triazole Derivative and Its Complexes with Some Transition Metal Ions." European Journal of Theoretical and Applied Sciences 2, no. 5 (2024): 579–84. https://doi.org/10.59324/ejtas.2024.2(5).55.

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An innovative class of ligand compounds using The ions of transition metals (Cr(III), Fe(III), and Ni(II)).The ligand N,N'-(4H-1,2,4-triazole-3,5-diyl)bis(4-methoxybenzamide) was produced by reacting 2,5-di amino-1,2,4-triazole with two moles of methyl 4-methoxybenzoate in the presence of ethanol and a few drops of glacial acetic acid. The recently produced chemicals were studied using a battery of analytical tools, analysis of elements (C, H, and N), nuclear magnetic resonance spectroscopy, Fourier transform infrared spectroscopy, mass spectrometry, and atomic absorption are some of the techn

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45

Martynyshyn, V. P., V. M. Hunchak, B. V. Gutyj, and O. P. Rudenko. "Prediction of biological activity of 4-(3,4 dimethoxybenzylidene)amino)-5-(2-fluorophenyl)-4H-1,2,4 triazole-3-thiol." Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies 26, no. 116 (2024): 255–59. https://doi.org/10.32718/nvlvet11637.

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Among the various heterocyclic systems, 1,2,4-triazole derivatives occupy a leading position due to a whole range of unique and valuable properties. 1,2,4-triazole derivatives exhibit a wide range of pharmacological activity, affecting various biochemical processes while having minimal toxicity. Due to their unique chemical structure, these heterocyclic compounds exhibit different biological properties, making them promising for developing new drugs. The work aimed to study new types of activity of 4-(3,4-dimethoxybenzylidene)amino)-5-(2-fluorophenyl)-4Н-1,2,4-triazole-3-thiol using in silico

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46

Maji, Krishnendu, and Debasish Haldar. "1-(2-aminophenyl)-1H-1,2,3-triazole-4-carboxylic acid: activity against Gram-positive and Gram-negative pathogens including Vibrio cholerae." Royal Society Open Science 4, no. 10 (2017): 170684. http://dx.doi.org/10.1098/rsos.170684.

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We report a new synthetic aromatic ε-amino acid containing a triazole moiety with antimicrobial potential against Gram-positive, Gram-negative and pathogenic bacteria including Vibrio cholerae . Structure–property relationship studies revealed that all the functional groups are essential to enhance the antimicrobial activity. The 1-(2-aminophenyl)-1H-1,2,3-triazole-4-carboxylic acid was synthesized by click chemistry. From X-ray crystallography, the amino acid adopts a kink-like structure where the phenyl and triazole rings are perpendicular to each other and the amine and acid groups maintain

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47

M, Heravi; Majid, M. Daraie, and N. Sarmasti. "Synthesis of polymer-supported Zn(II) as a novel and green nanocatalyst for promoting click reactions and using design of experiment for optimization of reaction conditions." Journal of Macromolecular Science, Part A: Pure and Applied Chemistry 57, no. 7 (2020): 488–98. https://doi.org/10.1080/10601325.2020.1725389.

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A novel, highly stable and green ZnCl<sub>2</sub> nanoparticles (NPs) of modified poly(styrene-co-maleic anhydride) (SMA) was prepared by a simple procedure and was used to investigate the efficiency of the Click reaction. In this regard, SMA was modified with 3-aminopyridine to obtain the corresponding poly(styrene-co-maleimide) (SMI). ZnCl<sub>2</sub> was immobilized onto SMI as NPs. The obtained Zn(II)-SMI nanocatalyst was characterized using various techniques including FTIR, energy-dispersive X-ray spectroscopy, scanning electron microscope image, thermogravimetric analysis and inductivel

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48

Mohd., Imran*. "ANTIMICROBIAL ACTIVITY EVALUATION OF SOME (Z)-2- (2-OXO-1-((ARYLAMINO)METHYL)INDOLIN-3-YLIDENE)-N- (4-(2-OXO-2H-CHROMEN-3-YL)THIAZOL-2-YL)HYDRAZINE- 1-CARBOXAMIDES." Indo American Journal of Pharmaceutical Sciences (IAJPS) 03, no. 09 (2016): 988–895. https://doi.org/10.5281/zenodo.154116.

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Fourteen(Z)-2-(2-oxo-1-((arylamino)methyl)indolin-3-ylidene)-N-(4-(2-oxo-2H-chromen-3-yl)thiazol-2 yl)hydrazine-1-carboxamides 4a-4n were prepared by treating (Z)-N-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)-2-(2- oxoindolin-3-ylidene)hydrazine-1-carboxamide 3 with the aryl amines and formaldehyde. The chemical structures of these compounds were elucidated by their physical constants, spectral data and elemental analysis. These compounds were investigated for their antimicrobial activity against five Gram-positive bacteria, namely, S. aureus, E. faecalis, S. epidermidis, B. subtilis and B. cereus

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Li, Ting, Bing Li, Xiao Yan Chen, et al. "Supramolecular Structure in the Cocrystal of 3, 5-Bispyridyl-1-H-1, 2, 4-Triazole and 4,4-Oxybis(Benzoic Acid)." Advanced Materials Research 781-784 (September 2013): 531–35. http://dx.doi.org/10.4028/www.scientific.net/amr.781-784.531.

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A new cocrystal (3,4-Hbpt)-(H2oba) (3,4-Hbpt =3-(3-pyridyl)-5-(4-pyridyl)- 1-H-1,2,4-triazole and H2oba=4,4-oxybis (benzoic acid)), was prepared via self-assembly in the presence of cobalt acetate as template by hydrothermal reactions. The title complex was characterized by single-crystal X-ray diffraction, elemental analysis and IR spectroscopy. Structural analysis reveals that the complex belongs to monoclinic system, space group P21/c. The two carboxylate groups from H2oba are not deprotonated and form two kinds of strong intermolecular hydrogen bonds with 3,4-Hbpt, which linking the molecu

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Parisi, Emmanuele, and Roberto Centore. "Stabilization of an elusive tautomer by metal coordination." Acta Crystallographica Section C Structural Chemistry 77, no. 7 (2021): 395–401. http://dx.doi.org/10.1107/s2053229621006203.

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The solid-state isolation of the different tautomers of a chemical compound can be a challenging problem. In many cases, tautomers with an energy very close to the most stable one cannot be isolated (elusive tautomers). In this article, with reference to the 4-methyl-7-(pyrazin-2-yl)-2H-[1,2,4]triazolo[3,2-c][1,2,4]triazole ligand, for which the elusive 3H-tautomer has an energy only 1.4 kcal mol−1 greater than the most stable 2H form, we show that metal complexation is a successful and reliable way for stabilizing the elusive tautomer. We have prepared two complexes of the neutral ligand with

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