Relevant bibliographies by topics / 1 3 4 oxadiazole derivatives synthesis biological activity

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  2. Dissertations / Theses
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Academic literature on the topic '1 3 4 oxadiazole derivatives synthesis biological activity'

Author: Grafiati
Published: 3 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "1 3 4 oxadiazole derivatives synthesis biological activity"

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Solet, Sanwar Mal, Neetesh Kumar Sharma, and Raghvendra Singh Bhadauria. "Biological Evaluation of Novel Synthesized 2, 5-disubstituted-1, 3, 4-oxadiazole derivatives." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 573–76. http://dx.doi.org/10.22270/jddt.v9i4-a.3522.

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Synthesis of a series of various 2, 5-disubstituted-1, 3, 4-oxadiazole derivatives (7a-7v) have been done previously. These novel synthesized derivatives (7a-7v) have been tested for their antibacterial activity against Gram +ve S. aureus and Gram -ve E. Coli bacterias by broth dilution method. A comparative study has been done for all derivatives. Based on the visual turbidity, the MIC of the evaluated molecules has been studied, the evaluation concentration was used single therefore, the exact MIC could not determined and results are represented in less than and more than based on growth of
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2

Farah, Deeba, Abbas Naeem, Tahir Butt Muhammad, Ahmad Khan Rauf, Muneeb Ahsan Muhammad, and Ain Khan Misbahul. "Synthesis, characterization and biological activities of 1,3,4-oxadiazole derivatives of nalidixic acid and their copper complexes." Chemistry International 4, no. 4 (2018): 206–15. https://doi.org/10.5281/zenodo.1475387.

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A series of novel 1, 3, 4-oxadiazole analogues was synthesized from cyclization of hydrazones of substituted 1-ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3-carbohydrazides were prepared from nalidixic acid. The structures of synthesized oxadiazole derivatives and their copper complexes were elucidated on the basis of FTIR, elemental analyses, 1H-NMR and atomic absorption spectral analysis. It was observed from spectral data that metal ligand ratio was 1:1 in all copper complexes and they were bidentate, coordination was found to be done through oxygen of 4-oxo group and nitrogen of oxa
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Rachel, Mathew* V. .S. Anjana Ayoona Najeeb Fathima Shereen S. Nikhila Anna Anil Saranya B. Sarin Santhosh. "COMMENCEMENT SCRUTINY OF 1,3,4-OXADIAZOLE; ITS VISCERAL ACTIVITIES." International Journal in Pharmaceutical Sciences 2, no. 5 (2024): 1265–74. https://doi.org/10.5281/zenodo.11264100.

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Oxadiazoles are a class of heterocyclic aromatic chemical compound of the azole family.1,3,4-oxadiazole is a nitrogen and oxygen containing heterocyclic derivative in which nitrogen in 3rd and 4th positions and oxygen in 1st position with chemical formula, C2 H2N2O and molecular weight 70.051g.mol-1. 1,3,4- oxadiazole is also known asOxdiazole,1-Oxa-3,4diazacyclopentadiene. 1,3,4- oxadiazole and its derivatives were used by several chemists for therapeutic conditions because it posses many pharmacological activities. 1,3,4- oxadiazole and its derivatives have great significance in medicinal ch
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Bhardwaj, Niti, S. K. Saraf, Pankaj Sharma, and Pradeep Kumar. "Syntheses, Evaluation and Characterization of Some 1, 3, 4-Oxadiazoles as Antimicrobial Agents." E-Journal of Chemistry 6, no. 4 (2009): 1133–38. http://dx.doi.org/10.1155/2009/698023.

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1,3,4-Oxadiazoles show various biological activities and have been synthesized from different compounds. 1,3,4-oxadiazole is popularly known for its antimicrobial, anti-inflammatory, pesticidal and antihypertensive activitiesetc. It is well known that the synthesis of heterocyclic compounds tend to contain multi-structure in a molecule. The ring formation involves the condensation reaction. The challenge is to develop the ring system by incorporating the indole nucleus into it through the proposed reaction scheme. There are two free positions for the substitution in the oxadiazole ring system.
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Amer, Hamada, Omar Ali, Akram Salama, Marwa gendy та Omima Houssin. "Synthesis of some new 1,3,4-oxadiazole derivatives bearing sugars and α-aminophosphonate derived from 4-nitrophenol as anticancer agents". National Journal of Physiology, Pharmacy and Pharmacology 2, № 1 (2018): 1275. https://doi.org/10.5455/njppp.2018.8.0416408052018-1.

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Background: 1,3,4-oxadiazoles square measure a very important category of heterocyclic compounds with a broad variety of biological activities such as medicament, analgesic, ulcerogenicity, apoptosis inducer, anti-mycobacterial, antifungal, antitumor, P-glycoprotein Inhibitors, pesticides, 4-hydroxylase inhibitors, and antiepileptic drug activity. Aims and Objectives: The present study is undertaken to study the evaluation of new 1,3,4-oxadiazole derivatives bearing sugars and α-aminophosphonate derived from 4-nitrophenol as anticancer agents. Materials and Methods: A sequence of acyclic nucle
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Muhammad, Abul Kashem Liton, Sajid Hasan Md., Helen Sabrina, Das Mukta, and Shalauddin Md. "Synthesis, Characterization and Biological Evaluation of Some 1,3,4-oxadiazole Incorporated Coumarin Derivatives as Antifungal Agents." AMERICAN JOURNAL OF PHARMTECH RESEARCH 12, no. 2 (2022): 61–70. https://doi.org/10.5281/zenodo.6659389.

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ABSTRACT Coumarins are the family of benzopyrones, in which benzene ring amalgamated with the pyrone ring. Their versatile oxygen-containing heterocyclic structure and physicochemical characteristics are responsible to attract great attention from medicinal chemists and pharmacologists and for being a privileged scaffold in medicinal chemistry. In this study, 1, 3, 4 -oxadiazole incorporated a series of new coumarin derivatives have been synthesized. Structures of the newly synthesized compounds were established on the basis of FT-IR, <sup>1</sup>H NMR spectroscopic techniques and elemental an
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Deeksha, Tiwari, Narang Rakesh, and Lal khokra Sukhbir. "A review on microwave assisted synthesis, mechanism of action and structure activity relationship of 1, 3, 4-oxadiazole derivatives as anticancer agent." World Journal of Advanced Research and Reviews 9, no. 1 (2021): 086–96. https://doi.org/10.5281/zenodo.4533782.

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1, 3, 4-oxadiazole derivatives received considerable attention of different research groups, as they have wide variety of biological activities. 1, 3, 4-oxadiazole derivatives exhibited noteworthy anticancer activities. In recent years, microwave-induced organic reactions attained significant attention due to several benefits, such as short reaction time, cost-effectiveness, excellent yield, and ease of work. In view of above in present work, SAR and mechanism of action of 1, 3, 4-oxadiazole derivatives as anticancer agents, reported by different research groups in recent years are summarized.
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Deeksha Tiwari, Rakesh Narang, and Sukhbir Lal khokra. "A review on microwave assisted synthesis, mechanism of action and structure activity relationship of 1, 3, 4-oxadiazoleA review on microwave assisted synthesis, mechanism of action and structure activity relationship of 1, 3, 4-oxadiazole derivatives as anticancer agent derivatives as anticancer agent." World Journal of Advanced Research and Reviews 9, no. 1 (2021): 086–96. http://dx.doi.org/10.30574/wjarr.2021.9.1.0472.

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1, 3, 4-oxadiazole derivatives received considerable attention of different research groups, as they have wide variety of biological activities. 1, 3, 4-oxadiazole derivatives exhibited noteworthy anticancer activities. In recent years, microwave-induced organic reactions attained significant attention due to several benefits, such as short reaction time, cost-effectiveness, excellent yield, and ease of work. In view of above in present work, SAR and mechanism of action of 1, 3, 4-oxadiazole derivatives as anticancer agents, reported by different research groups in recent years are summarized.
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Adeeb, Hajar. "A Review of Modern Methods of Synthesis 1, 3, 4-Oxadiazole as a Bioactive Compounds." Wasit Journal for Pure sciences 2, no. 4 (2023): 237–53. http://dx.doi.org/10.31185/wjps.262.

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ABSTRACT: Oxadiazole ring is a heterocyclic molecule with an oxygen and two nitrogen atoms spread throughout its five-membered structure. There are four different isomers that have been discovered, Because of their wide applications in a range of sectors, including medications . Some of these biological activity are; anticonvulsant capacity, anticancer as well, antibacterial, antiviral, antifungal, antimalarial, antitubercular, anti-asthmatic, antidepressant, antidiabetic, antioxidant, antiparkinsonian, analgesic and anti-inflammatory, are just some of the therapeutic uses that have drawn atte
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Variya, Hiren H., Vikram Panchal, Falguni G. Bhabhor, and G. R. Patel. "Synthesis and Characterization of Biologically Potent Chalcone Bearing 1,3,4-Oxadiazole Linkage." International Letters of Chemistry, Physics and Astronomy 61 (November 2015): 77–83. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.61.77.

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In this article, we have described to design and synthesized a series of substituted chalcone based 1,3,4-oxadiazole derivatives. Titled compounds (E)-S-(-5-phenyl-1,3,4-oxadiazol-2-yl) 2-(4-(3-(5-methyl-3oxo-2(p-tolyl)-2,3-dihydro-1H-pyrazol-4-yl)-3-oxoprop-1-en-1-yl) phenoxy) etanethioate (III1-6) were synthesized using of derivatives of S-(-5-phenyl-1,3,4 oxadiazole-2-yl)2-chloroethaethioate (I1-6) were reacted with (E)-4-(3-(4-hydroxyphenyl) acryloyl)-5-methyl-2(p-tolyl)-1H-pyrazol-3(2H)-one (II) in presence of K2CO3 in DMF as a solvent. The synthesized compounds were evaluated for their a
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Dissertations / Theses on the topic "1 3 4 oxadiazole derivatives synthesis biological activity"

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Huang, Chun-Lung, and 黃俊龍. "Synthesis and biological activity of 1-benzyl-4-hydroxy-3-phenylquinolin-2(1H)-one derivatives." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/37426286995940238871.

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碩士<br>中國醫藥大學<br>藥物化學研究所碩士班<br>94<br>The dissertation is based on the structure of 4-hydroxy- quinolin-2-(1H)-ones. In order to synthesize a series of derivatives of 1-benzyl-4-hydroxy-3-phenylquinolin-2(1H)-one (26a-g, 27a-g, 28, 29), Using the Bheemashankar′s solution-phase combinatorial synthetic method. The starting material is methyl anthranilate (16) that is condensated with 4-substituted-benzaldehydes 17a-h to obtain the 19a-h. On the other hand, 4-cyanophenyl acetic acids 20a-d were acylated with thionyl chloride to afford acid chlorides 21a-d. Then, 21a-d and 19a-h are combined by Scho
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Book chapters on the topic "1 3 4 oxadiazole derivatives synthesis biological activity"

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Deshmukh, M. B., S. R. Yankanchi, S. M. Deshmukh, and Bhagawan Patil. "SYNTHESIS AND BIOLOGICAL INVESTIGATIONS OF NEWLY SYNTHESIZED SUBSTITUTED IMIDAZOLE [2, 1-C] [1, 2, 4] TRIAZOLE DERIVATIVES FROM IMIDACLOPRID." In Futuristic Trends in Chemical Material Sciences & Nano Technology Volume 3 Book 1. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bdcs1ch7.

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New molecules with promising insecticidal properties like imidazo[2,1-c][124] triazole analogs were synthesized, starting with imidacloprid and bio-assayed. The structures of synthesized molecules were confirmed with diverse modern methods like FT-IR, 1H NMR, 13C NMR, and Mass spectrometry. The synthesized molecules are screened to investigate their insecticidal and anti-bacterial activity. The bioassay screening showed that synthesized compounds chloro (3-(4-chlorophenyl)-7-[(6-chloropyridin-3-yl)methyl]-2,5,6,7-tetrahydro-3H-imidazo [2,1-c] [1,2,4] triazole (4b), the 3-(2-chlorophenyl)-7-[(6
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Jafeena, A. A., M. R. Ezhilarasi, and M. Suganthi. "SYNTHESIS, SPECTRAL CHARACTERIZATION, INSILCOMOLECULAR DOCKING STUDIES AND IN-VITRO ANTIMICROBIAL STUDIES OF 5-(4-SUBSTITUTED PHENYL)-3-(THIOPHEN-2-YL)-4, 5-DIHYDROPYRAZOLE-1-CARBOTHOAMIDE DERIVATIVES." In Futuristic Trends in Chemical Material Sciences & Nano Technology Volume 3 Book 11. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3becs11p2ch5.

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Using the melting point, Infra-red, 1-D1H and 13C NMR spectroscopic data, a new series of pyrimidines were harmonized and characterized. In vitro biological activities of all the harmonized compounds are tested. Also the same compound is tested by zone of inhibition against set of bacterial and fungal strains; by this the compound 2a tested against S.Aureus,S.Pyogenes, E.Coli, 4b against P.Aeruginosa, and this shows an excellent antibacterial activity. Similarly the compound 2c can show inhibition against C.albicans. And also all the compounds were undergone in-silico molecular docking predict
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Taber, Douglass F. "The Baran Synthesis of Ingenol." In Organic Synthesis. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190646165.003.0089.

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The early promise for the biological activity of the derivatives of ingenol 3 has been borne out by the clinical efficacy of the derived angelate, recently approved by the US Food and Drug Administration for the treatment of actinic keratosis. Phil S. Baran of Scripps La Jolla envisioned (Science 2013, 341, 878) a route to 3 based on a rearrange­ment of 2, available by the Pauson–Khand cyclization of the allenyl alkyne 1. One of the partners for the preparation of 1 was available following the Sugai (Synlett 1997, 1297) procedure, by the Claisen rearrangement of triethyl orthopro­pionate 5 wit
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Conference papers on the topic "1 3 4 oxadiazole derivatives synthesis biological activity"

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Matiková Maľarová, Miroslava, Alexandra Bilá, Mária Vilková, Erika Samoľová, Zuzana Jendželovská, and Viktória Buľková. "New vanadium complexes with potential biological activity." In 2nd International Conference on Chemo and Bioinformatics. Institute for Information Technologies, University of Kragujevac, 2023. http://dx.doi.org/10.46793/iccbi23.431mm.

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Two slightly different manner of syntheses lead to the formation of four molecular complexes with two type of coordination arrangement; brown complexes VO(iPrO)(dBrQ)2 (1), VO(iPrO)(5I7BrQ)2 (2) and dark green VO(Cl)(dBrQ)2 (3), VO(iPrO)(5I7BrQ)2 (4). The presence of water and isopropanol in synthesis plays a crucial role in the formation of these two types of complexes. Otherwise also some dinuclear oxo-bridged complexes with four quinoline-8-ol derivatives coordinated to vanadium (V) were obtained in this reactions scheme. The mononuclear complexes were characterized by elemental analysis, i
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Popusoi, Ana, Nicanor Barba, and Aurelian Gulea. "Synthesis of 1,3-Phenyl(Pyridyl)propenones with thiosemicarbazidic groups." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab03.

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The bibliographic study of chalcones of the type 1,3-aryl(heteryl)propen-2-one with thiosemicarbazidic 4- and 1,4-disubstituted and thisemicarbazonic groups respectively gives us the information that they have a wide spectrum of biological activity, but methods of their synthesis are less described in the literature, and they became our object of study. 4,5-Dihydro-1-H-(pyrazol-3-yl)phenylhydrazinecarbothioamides 3a and 3b were obtained according to the following scheme:Reagents and reaction conditions: i, ii) 2-Py, 25oC – 24h, 90-95oC – 3h, 77-82%; iii) DMF, CH3COOH, 70-80oC, 2-3h, 60-63%. Fi
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Pogrebnoi, Vsevolod, Natalia Sucman, and Fliur Macaev. "The spirocyclopropane with fragments of dehydroabietic acid and aminooxindole." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab15.

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The abstract presents the synthesis of new highly functionalized spirocyclopropane with the fragment of natural compound – dehydroabietic acid 1 (DAK), which can be potentially active against some diseases.It is a known that spirocyclopropanes have anti-HIV activity [1]. From the other side there are a lot of natural and synthetical oxindoles with various biological activities [2]. And the last fact – that the high optical purity and the molecular structure of tricyclic diterpenoid 1 make it an attractive object for studying new various properties, such as the synthesis of new derivatives with
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