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Journal articles on the topic '1,3,4-oxadiazole'

Author: Grafiati

Published: 4 June 2021

Last updated: 5 May 2022

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1

Verma, Garima, Mohemmed F. Khan, Wasim Akhtar, Mohammad Mumtaz Alam, Mymoona Akhter, and Mohammad Shaquiquzzaman. "A Review Exploring Therapeutic Worth of 1,3,4-Oxadiazole Tailored Compounds." Mini-Reviews in Medicinal Chemistry 19, no. 6 (2019): 477–509. http://dx.doi.org/10.2174/1389557518666181015152433.

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1,3,4-Oxadiazole, a five-membered aromatic ring can be seen in a number of synthetic molecules. The peculiar structural feature of 1,3,4-oxadiazole ring with pyridine type of nitrogen atom is beneficial for 1,3,4-oxadiazole derivatives to have effective binding with different enzymes and receptors in biological systems through numerous weak interactions, thereby eliciting an array of bioactivities. Research in the area of development of 1,3,4-oxadiazole-based derivatives has become an interesting topic for the scientists. A number of 1,3,4-oxadiazole based compounds with high therapeutic poten

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2

Kumar, Sahil, Rakesh Narang, Manish Devgun, and Sukhbir Lal. "ANTIMICROBIAL ACTIVITY AND SAR OF 2,5-DISUBSTITUTED 1,3,4-OXADIAZOLE DERIVATIVES." Journal of Advanced Scientific Research 13, no. 01 (2022): 1–22. http://dx.doi.org/10.55218/jasr.202213101.

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1,3,4-oxadiazole is a five membered heterocyclic aromatic moiety, present in a number of antimicrobial agents. 2,5- disubstituted 1,3,4-oxadiazole derivatives have shown broad spectrum of antibacterial and antifungal activities. Many scientific groups have synthesized and screened their antimicrobial potential. Reported activity data showed that some 1,3,4-oxadiazole derivatives exhibited better activity than already known antibiotics. Hence, they can be used as lead for development of promising antimicrobial agents. In present review, antimicrobial activities and SAR of 2,5-disubstituted 1,3,

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3

Tawade, Bhausaheb V., Nitin G. Valsange, and Prakash P. Wadgaonkar. "Synthesis and characterization of polyhydrazides and poly(1,3,4-oxadiazole)s containing multiple arylene ether linkages and pendent pentadecyl chains." High Performance Polymers 29, no. 7 (2016): 836–48. http://dx.doi.org/10.1177/0954008316660368.

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A new diacylhydrazide monomer, namely, 4-(4-(4-(4-(hydrazinocarbonyl)phenoxy)-2-pentadecylphenoxy)phenoxy) benzohydrazide (HPPDPB), was synthesized starting from 4-(4-hydroxyphenoxy)-3-pentadecylphenol. HPPDPB was polycondensed with terephthalic acid chloride (TPC), isophthalic acid chloride (IPC) and a mixture of TPC and IPC (50:50 mol%) to obtain polyhydrazides containing multiple arylene ether linkages in the backbone and pendent pentadecyl chains. Polyhydrazides were subsequently cyclized in the presence of phosphorus oxychloride to obtain the corresponding poly(1,3,4-oxadiazole)s. Polyhyd

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4

Journal, Baghdad Science. "Synthesis and Characterization of 1,3,4-Oxadiazoles Derived From 9-Fluorenone." Baghdad Science Journal 10, no. 2 (2013): 449–61. http://dx.doi.org/10.21123/bsj.10.2.449-461.

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In the present work, 9-fluorenone-2-carboxylic acid methyl ester (1) was prepared from 9-fluorenone-2-carboxylic acid and then converted into the acid hydrazide (2). Compound (2), is the key intermediate for the synthesis of several series of new compounds such as substituted 1,3,4-oxadiazole derivatives (3-6) were synthesized from the condensation of different substituted benzoic acids with compound (2) using POCl3 as condensing agent. Treatment of compound (2) with formic acid gave the N-formyl hydrazide (7), which upon refluxing with phosphorous pentoxide in benzene yielded the correspondin

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5

Mercer, Frank W. "Synthesis and characterization of aromatic poly(ether ketone oxadiazole)s." High Performance Polymers 5, no. 1 (1993): 69–76. http://dx.doi.org/10.1088/0954-0083/5/1/007.

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A general method for the preparation of oxadiazole containing aromatic poly(ether ketone)s has been developed. Polymerization is based on a ketone-activated halo displacement in oxadiazole containing bis(4-fluorobenzoyl) moieties by phenoxides. 2,5-bis[4-(4-fluorobenzoyl-(4-phenoxyphenyl)]-1,3,4-oxadiazole was prepared by reaction of 4-fluorobenzoyl chloride with 2,5-bis(4-phenoxyphenyl)-1,3,4-oxadiazole in dichloromethane in the presence of aluminium chloride. Reaction of 2,5-bis[4-(4-fiuorobenzoyl)-(4-phenoxyphenyl)]-1,3,4-oxadiazole with diphenols in an aprotic solvent in the presence of po

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6

Liu, Chengbin, Ping Zhao, and Wei Huang. "New oxadiazole derivatives as promising electron transport materials: synthesis and characterization of thermal, optical and electrochemical properties." Open Chemistry 5, no. 1 (2007): 303–15. http://dx.doi.org/10.2478/s11532-006-0052-y.

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Abstract2,5-bis-(4-biphenyl)-yl-1,3,4-oxadiazole (1a), 2,5-bis-(4-(6,8-difluoro)-biphenyl)-yl-1,3,4-oxadiazole (1b) and 2,5-bis-(4-(spiro-fluorenyl)-phenyl)-yl-1,3,4-oxadiazole (1c) were designed, synthesized and characterized. 1a–c were easily obtained from Suzuki reactions between 2,5-bis-(4-bromo-phynyl)-[1,3,4]oxadiazole (2) and aromatic boronic acids (3). They were characterized by 1H-NMR, DSC, TGA, UV-Vis, photoluminescence (PL) spectrometry and CV. The melting temperatures (T m) of 1a–c are 237, 208 and 370 °C, respectively, much higher than that of 2-tert-butylphenyl-5-biphenyl-1,3,4-o

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7

Jin, Guoxia, Yuqi Ji, Teng Wang, et al. "Syntheses and characterization of dinuclear and tetranuclear AgI supramolecular complexes generated from symmetric and asymmetric molecular clips containing oxadiazole rings." Acta Crystallographica Section C Structural Chemistry 75, no. 10 (2019): 1327–35. http://dx.doi.org/10.1107/s2053229619011744.

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A new asymmetric ligand, 5-{3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}-2-(pyridin-3-yl)-1,3,4-oxadiazole (L5), which contains two oxadiazole rings, was synthesized and characterized. The assembly of symmetric 2,5-bis(pyridin-3-yl)-1,3,4-oxadiazole (L1) and asymmetric L5 with AgCO2CF3 in solution yielded two novel AgI complexes, namely catena-poly[[di-μ-trifluoroacetato-disilver(I)]-bis[μ-2,5-bis(pyridin-3-yl)-1,3,4-oxadiazole]], [Ag2(C2F3O2)2(C12H8N4O)2] n or [Ag2(μ2-O2CCF3)2(L1)2] n (1), and bis(μ3-5-{3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]phenyl}-2-(pyridin-3-yl)-1,3,4-oxadiazole

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8

Wołek, Barbara, Mateusz Werłos, Magdalena Komander, and Agnieszka Kudelko. "Efficient Synthesis of Novel 1,3,4-Oxadiazoles Bearing a 4-N,N-Dimethylaminoquinazoline Scaffold via Palladium-Catalyzed Suzuki Cross-Coupling Reactions." Molecules 25, no. 21 (2020): 5150. http://dx.doi.org/10.3390/molecules25215150.

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Two series of novel (symmetrical and unsymmetrical) quinazolinylphenyl-1,3,4-oxadiazole derivatives were synthesized using palladium-catalyzed Suzuki cross-coupling reactions. The presented synthetic methodology is based on the use of bromine-substituted 2-phenyl-4-N,N-dimethylaminoquinazolines and either a boronic acid pinacol ester or a diboronic acid bis(pinacol) ester of 2,5-diphenyl-1,3,4-oxadiazole. The reactions are conducted in a two-phase solvent system in the presence of catalytic amounts of [1,1′-bis(diphenylphosphino)ferrocene]-dichloropalladium(II), sodium carbonate, and tetrabuty

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9

Makwana, Hitesh, and Yogesh T. Naliapara. "Synthesis, Characterization and Biological Evaluation of 2,5-di-Substituted 1,3,4-Oxadiazole Derivatives." International Letters of Chemistry, Physics and Astronomy 34 (May 2014): 48–54. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.34.48.

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We have reported some novel 1,3,4-oxadiazole synthesized by conventional method .The reaction of 5-bromothiophene-2-carbohydrazide and different benzoic acid derivatives reflux in toluene using phosphorus oxychloride as a catalyst, yielded a series of 2,5-di-substituted 1,3,4-oxadiazole HM-2a to HM-2t. The newly synthesized 2,5-di-substituted 1,3,4-oxadiazole were purified by column chromatography and characterized by IR, Mass, 1H NMR, 13C NMR spectroscopy and elemental analysis. All synthesized compounds were screened for antimicrobial activity using cup plate method. All the compounds showed

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10

Bruma, Maria, and Mariana-Dana Damaceanu. "Polyimides Containing 1,3,4-Oxadiazole Rings." Collection of Czechoslovak Chemical Communications 73, no. 12 (2008): 1631–44. http://dx.doi.org/10.1135/cccc20081631.

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Two series of polyimides containing 1,3,4-oxadiazole rings in the main chain, one of them having flexible hexafluoropropane-2,2-diyl groups and the other with carbonyl groups, were prepared by polycondensation of aromatic diamines containing 1,3,4-oxadiazole rings with hexafluoropropane-2,2-diyl-bis(phthalic anhydride) or benzophenonetetracarboxylic dianhydride. Their properties, such as solubility in organic solvents, thermal stability, glass transition temperature, photoluminescence and film-forming properties of the two groups of polymers have been studied and compared.

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11

Tauchman, Jiří, Jakub Trnka, Ivana Císařová, and Petr Štěpnička. "Synthesis, crystal structures and electrochemistry of ferrocenyl-substituted 1,3,4-oxadiazoles." Collection of Czechoslovak Chemical Communications 75, no. 10 (2010): 1023–40. http://dx.doi.org/10.1135/cccc2010064.

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Two ferrocenyl-substituted 1,3,4-oxadiazoles, 2-ferrocenyl-1,3,4-oxadiazole (1) and 2,5-diferrocenyl-1,3,4-oxadiazole (2), have been prepared from the corresponding hydrazides, (ferrocenecarbonyl)hydrazine (3) and 1,2-bis(ferrocenecarbonyl)hydrazine (4), and characterized by conventional spectroscopic methods (IR, NMR, MS) and elemental analyses. The solid-state structures of 1, 2 and 4 have been determined by single-crystal X-ray diffraction analysis. The redox behavior of 1 and 2 was studied by electrochemical methods. Compound 1 underwent a reversible one-electron oxidation attributed to th

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12

Dave, S. B., P. Godhani, and Y. Ushir. "ChemInform Abstract: 1,3,4-Oxadiazole." ChemInform 45, no. 14 (2014): no. http://dx.doi.org/10.1002/chin.201414251.

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13

Jin, Guo-Xia, Tian-Chao You, and Jian-Ping Ma. "Three AgI, CuI and CdII coordination polymers based on the new asymmetrical ligand 2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole: syntheses, characterization and emission properties." Acta Crystallographica Section C Structural Chemistry 75, no. 12 (2019): 1690–97. http://dx.doi.org/10.1107/s2053229619015663.

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The new asymmetrical organic ligand 2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole (L, C17H13N5O), containing pyridine and imidazole terminal groups, as well as potential oxdiazole coordination sites, was designed and synthesized. The coordination chemistry of L with soft AgI, CuI and CdII metal ions was investigated and three new coordination polymers (CPs), namely, catena-poly[[silver(I)-μ-2-{4-[(1H-imidazol-1-yl)methyl]phenyl}-5-(pyridin-4-yl)-1,3,4-oxadiazole] hexafluoridophosphate], {[Ag(L)]PF6} n , catena-poly[[copper(I)-di-μ-iodido-copper(I)-bis(μ-2-{4-[(1H-imi

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14

Journal, Baghdad Science. "Synthesis and Characterization of some New 1,3,4-Oxadiazole derivatives based on 4-amino benzoic acid." Baghdad Science Journal 13, no. 4 (2016): 762–69. http://dx.doi.org/10.21123/bsj.13.4.762-769.

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Various of 2,5- disubstituted 1,3,4-oxadiazole (Schiff base, ?- lactam and azo) were synthesized from 2,5-di (4,4?-amino-1,3,4-oxadiazole which usequently synth-esized from mixture of 4- amino benzoic acid and hydrazine arch of polyphosphorus acid. The synthesized compounds were cherecterized by using some spectral data (UV, FT-IR , and 1H-NMR)

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15

Namera, Dipti L., and Umed C. Bhoya. "Convenient Synthesis of the 2,5-di-Substituted 1,3,4-Oxadiazole Derivatives under Microwave." International Letters of Chemistry, Physics and Astronomy 30 (March 2014): 159–66. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.30.159.

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We have reported some novel 1,3,4-oxadiazole synthesized by conventional method as well as microwave assisted method. The reaction of different substituted cinnamic acid 2a-o with 2-(4-chlorophenyl) acetohydrazide by using phosphoric anhydride as catalyst, yielded a series of 2,5-di-substituted 1,3,4-oxadiazole 6a-o. The structures of all synthesized compounds are well characterized by Mass, FT-IR, 1H NMR, 13C NMR and elemental analysis. After obtaining experimental data regarding the yield and the time taken for the synthesis by both the methods, conventional and microwave assisted method, it

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16

Ganesh, Shimoga D., Vasantakumar K. Pai, Mahadevappa Y. Kariduraganavar, and Madhu B. Jayanna. "Functional Aromatic Poly(1,3,4-Oxadiazole-Ether)s with Benzimidazole Pendants: Synthesis, Thermal and Dielectric Studies." International Scholarly Research Notices 2014 (October 8, 2014): 1–8. http://dx.doi.org/10.1155/2014/790702.

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Poly(1,3,4-oxadiazole-ether) with reactive carboxylic acid pendants was synthesized from solution polymerization via nucleophilic displacement polycondensation among 2,5-bis(4-fluorophenyl)-1,3,4-oxadiazole (BFPOx) and 4,4′-bis(4-hydroxyphenyl) valeric acid (BHPA). Without altering the polymeric segments, benzimidazole modified poly(1,3,4-oxadiazole-ether)s were prepared by varying stoichiometric ratios of 1,2-phenylenediamine. The molecular structural characterization of these polymers was achieved by, FT-IR, NMR, TGA, elemental analysis, and analytical techniques. The weight-average molecula

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17

Tan, Ting Feng, Bian Peng Wu, Li Gang Bai, Yan Xia Li, and Ming Jie Zhang. "Synthesis and Optical Properties of Asymmetric Naphthylmethylene 1,3,4-Oxadiazole Derivatives." Advanced Materials Research 1033-1034 (October 2014): 1109–13. http://dx.doi.org/10.4028/www.scientific.net/amr.1033-1034.1109.

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Asymmetric 2-p-nitrophenyl-5-naphthylmethylene-1,3,4-oxadiazole and 2-p-aminophenyl-5-naphthylmethylene-1,3,4-oxadiazole were synthesized and characterized by IR、1HNMR and MS analysis, and their optical properties were detected using UV-vis absorption spectroscopy and fluorescence spectroscopy. The existence of electron-withdrawing oxadiazole units causes a significant bathochromic shift of the UV absorption maximum. The largest UV-absorption peak of target compounds is in the range of 298-317 nm, and a new emission band at 402 nm is formed. The fluorescence intensity is gradually enhanced, wh

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18

Camacho, Cristián M., Marianela G. Pizzio, David L. Roces, et al. "Design, synthesis and cytotoxic evaluation of a library of oxadiazole-containing hybrids." RSC Advances 11, no. 47 (2021): 29741–51. http://dx.doi.org/10.1039/d1ra05602f.

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19

Bhardwaj, Niti, S. K. Saraf, Pankaj Sharma, and Pradeep Kumar. "Syntheses, Evaluation and Characterization of Some 1, 3, 4-Oxadiazoles as Antimicrobial Agents." E-Journal of Chemistry 6, no. 4 (2009): 1133–38. http://dx.doi.org/10.1155/2009/698023.

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1,3,4-Oxadiazoles show various biological activities and have been synthesized from different compounds. 1,3,4-oxadiazole is popularly known for its antimicrobial, anti-inflammatory, pesticidal and antihypertensive activitiesetc. It is well known that the synthesis of heterocyclic compounds tend to contain multi-structure in a molecule. The ring formation involves the condensation reaction. The challenge is to develop the ring system by incorporating the indole nucleus into it through the proposed reaction scheme. There are two free positions for the substitution in the oxadiazole ring system.

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20

Journal, Baghdad Science. "Synthesis, Characterization of some New 1, 3, 4-Oxadiazole derivatives based on 4- amino benzoic acid." Baghdad Science Journal 13, no. 2 (2016): 289–97. http://dx.doi.org/10.21123/bsj.13.2.289-297.

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In this research various of 2,5-disubstituted 1,3,4-oxadiazole (Schiff base, oxo-thiazolidine , and other compounds) were synthesized from 2,5-di(4,4?- amino-1,3,4-oxadiazole ) which use quently synthesized from mixture of 4-amino benzoic acid and hydrazine in the presence of polyphosphorus acid. The synthesized compounds were characterized by using some Spectral data (UV, FT-IR, and 1H-NMR).

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21

Mathew, Glory, R. Krishnan, Molly Antony, and M. S. Suseelan. "Synthesis, Spectral Characterization and Biocidal Studies of Copper(II) Complexes of Chromen-2-one-3-carboxy Hydrazide and 2-(Chromen-3'-onyl)-5-(aryl)-1,3,4-oxadiazole Derivatives." E-Journal of Chemistry 8, no. 3 (2011): 1346–54. http://dx.doi.org/10.1155/2011/240196.

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Copper(II) complexes of chromen-2-one-3-carboxyhydrazide and 2-(chromen-3'-onyl)-5-(aryl)-1,3,4-oxadiazole derivatives have been synthesized. The structural features have been determined from their microanalytical, magnetic susceptibility, molar conductance, IR, UV Vis,1H NMR and ESR spectral data. All the Cu(II) complexes exhibit the composition Cu(Ln)2X2; where L1= chromen-2-one-3-carboxy hydrazide, L2 = 2-(chromen-3'-onyl)-5-(2ʺ-hydroxy phenyl)-1,3,4-oxadiazole, L3 = 2-(chromen-3'-onyl)-5-(4ʺ-nitrophenyl)-1,3,4 -oxadiazole and L4 = 2-(chromen-3'-onyl)-5-(4ʺ-chlorophenyl)-1,3,4-oxadiazole; X

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22

Glomb, Teresa, and Piotr Świątek. "Antimicrobial Activity of 1,3,4-Oxadiazole Derivatives." International Journal of Molecular Sciences 22, no. 13 (2021): 6979. http://dx.doi.org/10.3390/ijms22136979.

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The worldwide development of antimicrobial resistance forces scientists to search for new compounds to which microbes would be sensitive. Many new structures contain the 1,3,4-oxadiazole ring, which have shown various antimicrobial activity, e.g., antibacterial, antitubercular, antifungal, antiprotozoal and antiviral. In many publications, the activity of new compounds exceeds the activity of already known antibiotics and other antimicrobial agents, so their potential as new drugs is very promising. The review of active antimicrobial 1,3,4-oxadiazole derivatives is based on the literature from

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23

de Miguel, Maykel, Mercedes Álvaro, Jianfu Ding, and Hermenegildo García. "Photophysics of Fluorene Copolymers Containing 1,3,4-Oxadiazole or 1,3,4-Oxadiazole and Carbazole Units." Journal of Physical Chemistry C 114, no. 33 (2010): 14255–60. http://dx.doi.org/10.1021/jp104725u.

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24

Spandana, Zanjam, Reddymasu Sreenivasulu, Tadigiri MalathiRekha, and Mandava Venkata Basaveswara Rao. "Novel 1,3,4-Oxadiazole Fused Thiadiazole Derivatives: Synthesis and study of Anticancer Activities." Letters in Drug Design & Discovery 16, no. 6 (2019): 656–62. http://dx.doi.org/10.2174/1570180816666181031125946.

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Background: In search of novel anticancer agents, a series of 1,3,4-oxadiazole derivatives (12a-j) containing 1,3,4-thiadiazole moieties were synthesized, and their structures were confirmed by 1HNMR, 13CNMR and ESI-MS spectral analysis. Methods: Cytotoxicity of these compounds was evaluated by MTT assay in vitro against four human tumor cell lines, i.e. A549 (lung), MCF-7 (breast), A375 (melanoma) and HT-29 (colon). Results: Here, CA4 used as positive control. Among them, compounds 12b, 12c, 12f, 12g, 12h and 12j were exhibited promising activity than control drug. Conclusion: In conclusion,

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25

Bąchor, Urszula, Ewa Drozd-Szczygieł, Remigiusz Bąchor, Lucjan Jerzykiewicz, Robert Wieczorek, and Marcin Mączyński. "New water-soluble isoxazole-linked 1,3,4-oxadiazole derivative with delocalized positive charge." RSC Advances 11, no. 47 (2021): 29668–74. http://dx.doi.org/10.1039/d1ra05116d.

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26

Liu, Hua, Lin Lu, and Dun Jia Wang. "Synthesis and Optical Properties of some Novel Bis-1,3,4-Oxadiazoles." Advanced Materials Research 1104 (May 2015): 131–35. http://dx.doi.org/10.4028/www.scientific.net/amr.1104.131.

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Three 2,6-bis (1,3,4-oxadiazol-2-yl) pyridine derivatives were synthesized and their structures were conformed by1H NMR, FTIR, MS techniques and elemental analysis. The UV–Vis absorption and fluorescence emission spectra of these compounds were investigated in chloroform solution. The results showed that these bis-1,3,4-oxadiazole derivatives had broad and strong absorption at 278−302 nm in the UV–Vis spectra and exhibited fluorescence emission at 338 −367 nm under UV illumination in fluorescence spectra. It was found that the nature of the substituents at benzene ring in bis-1,3,4-oxadiazole

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27

Bala, Suman, Sunil Kamboj, Vipin Saini, and D. N. Prasad. "Anti-Inflammatory, Analgesic Evaluation and Molecular Docking Studies of N-Phenyl Anthranilic Acid-Based 1,3,4-Oxadiazole Analogues." Journal of Chemistry 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/412053.

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A novel series of N-phenyl anthranilic acid-based 1,3,4-oxadiazoles were prepared (4a–h) and subjected to anti-inflammatory, analgesic activity and molecular docking studies to target cyclooxygenase-2 enzyme. 1,3,4-Oxadiazole derivatives were screened for anti-inflammatory activity in carrageenan-induced rat paw edema and analgesic activity by tail immersion method. In synthesized compounds, the free carboxylic group, which is responsible for gastric side effects, was derivatized by heterocyclic 1,3,4-oxadiazole bioactive core, which showed good interaction with COX-2 receptor with good dockin

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Tang, Yongxing, Chunlin He, Lauren A. Mitchell, Damon A. Parrish, and Jean'ne M. Shreeve. "Energetic compounds consisting of 1,2,5- and 1,3,4-oxadiazole rings." Journal of Materials Chemistry A 3, no. 46 (2015): 23143–48. http://dx.doi.org/10.1039/c5ta06898c.

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3-Nitroamino-4-(5-amino-1,3,4-oxadiazol-2-yl)furazan monohydrate (2·H<sub>2</sub>O), which is a combination of the nitroaminofurazan and 1,3,4-oxadiazole rings, was obtained by the nitration of 3-amino-4-(5-amino-1,3,4-oxadiazol-2-yl)furazan (1) with 100% nitric acid.

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29

Hosseinihashemi, Seyyed Khalil, Mahsa Toolabi, Fahimeh Abedinifar, et al. "Synthesis and activity evaluation of new benzofuran-1,3,4-oxadiazole hybrids against wood-degrading fungi." BioResources 15, no. 1 (2019): 1085–97. http://dx.doi.org/10.15376/biores.15.1.1085-1097.

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A series of novel benzofuran-1,3,4-oxadiazole hybrids were synthesized and evaluated as antifungal agents. The synthetic pathway was started from salicylaldehyde, which afforded 5-(substituted benzylthio)-1,3,4-oxadiazole derivatives in moderate to good yields. The compounds were investigated for their antifungal potential against white-rot, Trametes versicolor and brown-rot, Poria placenta and Coniophora puteana fungi at different concentrations (500, 1000 ppm). The obtaining results demonstrated that most of the compounds at 500 ppm concentration did not exhibit acceptable antifungal effects

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30

Meng, Xingang, Niao Wang, Xiaofang Long, Lingzhu Chen, and Deyu Hu. "Qualitative and Quantitative Analysis of the New Sulfone Bactericide 2-(4-Fluorophenyl)-5-(Methylsulfonyl)-1,3,4-Oxadiazole and Identification of Its Degradation Pathways in Paddy Water." Journal of Chromatographic Science 58, no. 9 (2020): 859–67. http://dx.doi.org/10.1093/chromsci/bmaa055.

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Abstract Rapid and simple methods for the determination of Jiahuangxianjunzuo (JHXJZ) in paddy water, brown rice, soil and rice straw was developed and validated. This method involved the use of ultrahigh-performance liquid chromatography equipped with photodiode array detector. The most important factor was chromatographic conditions, as identified through an orthogonal experimental design. This method showed good recoveries and precisions, thereby indicating its suitability for monitoring of JHXJZ residues in paddy water, brown rice, soil and rice straw. Furthermore, hydrolysis experiment wa

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31

Han, Jie, Feng Yan Zhang, and Juan Yu Wang. "Synthesis and Mesomorphic Property of 2,5-Aryl-1,3,4-Oxadiazole/Thiadiazole Derivatives Bearing a Terminal Thiophene Unit." Key Engineering Materials 428-429 (January 2010): 52–56. http://dx.doi.org/10.4028/www.scientific.net/kem.428-429.52.

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The synthesis and characterization of a series of heterocyclic compounds 2a-2d based on 1,3,4-oxadiazole/ thiadiazole, furan and thiophene units are reported. The thermal behaviors of these compounds were investigated by means of differential scanning calorimetry (DSC), polarizing optical microscopy (POM) and thermogravimetric analysis (TGA). The 1,3,4-thiadiazole derivative 2b exhibited enantiotropic smectic C and A mesophases with wide temperature range and good thermal stability, while all of the other compounds did not show liquid crystalline behaviors. The results indicate that 1,3,4-thia

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32

Wang, Pin-Liang, Si-Shun Kang, Hai-Ling Li, Hai-Su Zeng, and Hai-Bo Wang. "2-Methyl-5-[3-(4-nitrophenyl)-1,2,4-oxadiazol-5-ylmethylenesulfanyl]-1,3,4-thiadiazole." Acta Crystallographica Section E Structure Reports Online 63, no. 11 (2007): o4236. http://dx.doi.org/10.1107/s1600536807047812.

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The title compound, C12H9N5O3S2, was synthesized via condensation of 1,2,4-oxadiazole chloromethane with 1,3,4-thiadiazolethiol. The benzene and oxadiazole rings are almost coplanar, making a twist angle of only 4.6 (3)°, but the thiadiazole ring deviates from the molecular plane, making a dihedral angle of 87.9 (3)° with the oxadiazole ring.

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33

Luczynski, Marcin, and Agnieszka Kudelko. "Synthesis and Biological Activity of 1,3,4-Oxadiazoles Used in Medicine and Agriculture." Applied Sciences 12, no. 8 (2022): 3756. http://dx.doi.org/10.3390/app12083756.

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Biologically active compounds play a key role in the fight against diseases affecting both human and animal living organisms, as well as plants. Finding out about new molecules with a potential biological effect, not yet described in the literature, is one of the most important aspects in the development of medicine and agriculture. Compounds showing desirable biological activity include heterocyclic moieties such as 1,3,4-oxadiazoles. The oxadiazole molecule is composed of two nitrogen atoms and one oxygen atom, forming a five-membered heterocyclic ring. Structures of this type have been succ

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34

Glomb, Teresa, Karolina Szymankiewicz, and Piotr Świątek. "Anti-Cancer Activity of Derivatives of 1,3,4-Oxadiazole." Molecules 23, no. 12 (2018): 3361. http://dx.doi.org/10.3390/molecules23123361.

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Compounds containing 1,3,4-oxadiazole ring in their structure are characterised by multidirectional biological activity. Their anti-proliferative effects associated with various mechanisms, such as inhibition of growth factors, enzymes, kinases and others, deserve attention. The activity of these compounds was tested on cell lines of various cancers. In most publications, the most active derivatives of 1,3,4-oxadiazole exceeded the effect of reference drugs, so they may become the main new anti-cancer drugs in the future.

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35

Ramazani, Ali, Yavar Ahmadi, and Fatemeh Zeinali Nasrabadi. "Four-component Synthesis of 1,3,4-Oxadiazole Derivatives from (N-Isocyanimino)triphenylphosphorane, (E)-Cinnamic Acids, Acetaldehyde and Secondary Amines." Zeitschrift für Naturforschung B 66, no. 2 (2011): 184–90. http://dx.doi.org/10.1515/znb-2011-0211.

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The 1 : 1 iminium intermediate, generated by the addition of a secondary amine to acetaldehyde is trapped by the (N-isocyanimino)triphenylphosphorane in the presence of an (E)-cinnamic acid derivative, leading to the formation of the corresponding iminophosphorane intermediate. Disubstituted 1,3,4-oxadiazole derivatives are formed via intramolecular aza-Wittig reaction of the iminophosphorane intermediates. The reactions were completed under neutral conditions at room temperature, and the corresponding disubstituted 1,3,4-oxadiazole derivatives were produced in excellent yields.

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36

Soleiman-Beigi, Mohammad, Reza Aryan, Maryam Yousofizadeh, and Shima Khosravi. "A Combined Synthetic and DFT Study on the Catalyst-Free and Solvent-Assisted Synthesis of 1,3,4-Oxadiazole-2-thiol Derivatives." Journal of Chemistry 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/476358.

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A novel practical and efficient catalyst-free method for the synthesis of 5-substituted 1,3,4-oxadiazole-2-thiols has been developed, which is assisted by reaction solvent (DMF). The solvent effects on product selectivity were studied based on Onsager’s reaction field theory of electrostatic solvation. The ab initio theoretical studies on the effect of solvents on the process also supported the suitability of DMF as the reaction medium for the preparation of 1,3,4-oxadiazole-2-thiol derivatives.

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37

Girdziunaite, Dalia, Carsten Tschierske, Eva Novotna, Horst Kresse, and Annemarie Hetzheim. "New mesogenic 1,3,4-oxadiazole derivatives." Liquid Crystals 10, no. 3 (1991): 397–407. http://dx.doi.org/10.1080/02678299108026286.

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38

Wang, X., W. Wang, H. X. Liu, M. Y. Tan, and M. Li. "A Derivative of 1,3,4-Oxadiazole." Acta Crystallographica Section C Crystal Structure Communications 51, no. 8 (1995): 1585–87. http://dx.doi.org/10.1107/s010827019400510x.

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39

Frazer, A. H., and T. A. Reed. "Aromatic Poly-1,3,4-Oxadiazole Fibers." Journal of Polymer Science Part C: Polymer Symposia 19, no. 1 (2007): 89–94. http://dx.doi.org/10.1002/polc.5070190111.

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40

Han, Jie. "1,3,4-Oxadiazole based liquid crystals." Journal of Materials Chemistry C 1, no. 47 (2013): 7779. http://dx.doi.org/10.1039/c3tc31458h.

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41

Bâcu, Elena, Magda Petrovanu, Axel Couture, and Pierre Grandclaudon. "SYNTHESE D'HYBRIDES 1,3,4-OXADIAZOLE-PHENOTHIAZINE." Phosphorus, Sulfur, and Silicon and the Related Elements 149, no. 1 (1999): 207–20. http://dx.doi.org/10.1080/10426509908037032.

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42

Zhao, Hang-Ju, Jian-Ping Ma, Qi-Kui Liu, and Yu-Bin Dong. "ZnIIand CuIIcomplexes generated from 5-(pyridin-4-yl)-3-[2-(pyridin-4-yl)ethyl]-1,3,4-oxadiazole-2(3H)-thione." Acta Crystallographica Section C Crystal Structure Communications 69, no. 7 (2013): 716–20. http://dx.doi.org/10.1107/s0108270113012134.

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A new 1,3,4-oxadiazole-containing bispyridyl ligand, namely 5-(pyridin-4-yl)-3-[2-(pyridin-4-yl)ethyl]-1,3,4-oxadiazole-2(3H)-thione (L), has been used to create the novel complexes tetranitratobis{μ-5-(pyridin-4-yl)-3-[2-(pyridin-4-yl)ethyl]-1,3,4-oxadiazole-2(3H)-thione}zinc(II), [Zn2(NO3)4(C14H12N4OS)2], (I), andcatena-poly[[[dinitratocopper(II)]-bis{μ-5-(pyridin-4-yl)-3-[2-(pyridin-4-yl)ethyl]-1,3,4-oxadiazole-2(3H)-thione}] nitrate acetonitrile sesquisolvate dichloromethane sesquisolvate], {[Cu(NO3)(C14H12N4OS)2]NO3·1.5CH3CN·1.5CH2Cl2}n, (II). Compound (I) presents a distorted rectangular

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43

Fun, Hoong-Kun, Suhana Arshad, P. C. Shyma, Balakrishna Kalluraya, and T. Arulmoli. "1-[2-(4-Chlorophenyl)-5-phenyl-2,3-dihydro-1,3,4-oxadiazol-3-yl]ethanone." Acta Crystallographica Section E Structure Reports Online 68, no. 6 (2012): o1901. http://dx.doi.org/10.1107/s1600536812023100.

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In the title compound, C16H14ClN3O2, the 2,3-dihydro-1,3,4-oxadiazole ring [maximum deviation = 0.030 (1) Å] and the pyridine ring [maximum deviation = 0.012 (1) Å] are inclined slightly to one another, making a dihedral angle of 11.91 (5)°. The chloro-substituted phenyl ring is almost perpendicular to the 2,3-dihydro-1,3,4-oxadiazole and pyridine rings at dihedral angles of 86.86 (5) and 75.26 (5)°, respectively. In the crystal, π–π [centroid–centroid distance = 3.7311 (6) Å] and C—H...π interactions are observed.

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44

Journal, Baghdad Science. "Synthesis, Characterization and study biologicalactivity of several 1-cyclopentene-1,2-dicarboxylimidyl Containing oxadiazole and Benzothiazole." Baghdad Science Journal 11, no. 2 (2014): 429–37. http://dx.doi.org/10.21123/bsj.11.2.429-437.

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In this work involved prepared of several new 1-cyclopentene-1,2-dicarboxylimide linked to oxadiazole and benzothiazole moiety were synthesized by two steps: The first step 2-amino-substituted-1,3,4-oxadiazoles and substituted-2-aminobenzothiazole were reaction with 1-cyclopentene-1,2-dicarboxyl anhydride producing N-( 5- substituted-1,3,4-oxadiazole-2-yl)-1-cyclopentene-1,2-dicarboxyl amic acids and N-(Substitutedbenzothiazole-2-yl)-1-cyclopentene-1,2-dicarboxyl amic acids which in turn were dehydrated in the second step via fusion method to afford he desirable N-(5-substituted-1,3,4-oxadiazo

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45

Hkiri, Shaima, Christophe Gourlaouen, Soufiane Touil, Ali Samarat та David Sémeril. "1,3,4-Oxadiazole-functionalized α-amino-phosphonates as ligands for the ruthenium-catalyzed reduction of ketones". New Journal of Chemistry 45, № 25 (2021): 11327–35. http://dx.doi.org/10.1039/d1nj01861b.

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46

Taieb Brahimi, F., F. Belkhadem, B. Trari, and A. A. Othman. "Diazole and triazole derivatives of castor oil extract: synthesis, hypoglycemic effect, antioxidant potential and antimicrobial activity." Grasas y Aceites 71, no. 4 (2020): 378. http://dx.doi.org/10.3989/gya.0342191.

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The ricinoleate triglyceride was extracted from castor-oil seeds grown in Algeria and isolated by catalytically methanolyse to methyl ricinoleate. Six diazole and triazole derivatives of ricinoleic acid were synthesized and characterized: 1,3,4-oxadiazole-5-thione (4); 1,3,4-thiadiazole-5-thione (5); 4-N-amino-1,2,4-triazole-5-thiol (7); 1,2,4-triazole-5-thione (9); 5-amino-1,3,4-oxadiazole (10) and 5-amino-1,3,4-thiadiazole (11). The antibacterial and antifungal screening data of synthesized compounds showed appreciable inhibition and among them, 5, 7 and 8 showed more inhibition on Gram posi

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47

Lelyukh, M. I. "Biological activity of heterocyclic systems based on functionally substituted 1,3,4-thia(oxa)diazoles (a review)." Farmatsevtychnyi zhurnal, no. 6 (December 21, 2019): 43–53. http://dx.doi.org/10.32352/10.32352/0367-3057.6.19.05.

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1,3,4-Thiadiazole and oxadiazole hetetocycles are well-known pharmacophore scaffolds, which possess wide possibility for chemical modification and identified diverse pharmacological potential. Such essential and many-sided activities let to consider the mentioned heterocycles as ones of the crucial for expression of pharmacological activity, which confirm their importance for medicinal chemistry. Moreover, 1,3,4-oxadiazole cycle is a bioisostere for carboxylic, amide and ester groups, which mostly contribute to enhancement the pharmacological activity by participating in hydrogen bonding inter

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48

Al-Alshaikh, Monirah A., Hatem A. Abuelizz, Ali A. El-Emam, Mohammed S. M. Abdelbaky, and Santiago Garcia-Granda. "Crystal structure of 3-{[4-(2-methoxyphenyl)piperazin-1-yl]methyl}-5-(thiophen-2-yl)-1,3,4-oxadiazole-2(3H)-thione." Acta Crystallographica Section E Crystallographic Communications 72, no. 2 (2016): 269–72. http://dx.doi.org/10.1107/s2056989016000992.

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The title compound, C18H20N4O2S2, is a new 1,3,4-oxadiazole and a key pharmacophore of several biologically active agents. It is composed of a methyl(thiophen-2-yl)-1,3,4-oxadiazole-2(3H)-thione moiety linked to a 2-methoxyphenyl unitviaa piperazine ring that has a chair conformation. The thiophene ring mean plane lies almost in the plane of the oxadiazole ring, with a dihedral angle of 4.35 (9)°. The 2-methoxyphenyl ring is almost normal to the oxadiazole ring, with a dihedral angle of 84.17 (10)°. In the crystal, molecules are linked by weak C—H...S hydrogen bonds and C—H...π interactions, f

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49

Jalhan, Sunny. "Review Article: Various Biological Activities of Coumarin and Oxadiazole Derivatives." Asian Journal of Pharmaceutical and Clinical Research 10, no. 7 (2017): 38. http://dx.doi.org/10.22159/ajpcr.2017.v10i7.18461.

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In this review article data is collected regarding the various derivatives of coumarin and oxadiazole as both these have wide range of biological activities and they can be further modified to synthesize more effective and potent drugs. Coumarin class of organic compounds consists of 1,2-benzopyrone ring system as a basic parent scaffold. These benzopyrones are subdivided into alpha-benzopyrones and gamma benzopyrones; with coumarin class of compounds belonging to alpha-benzopyrones. Since the last few years, coumarins were synthesized in many of their derivative forms. Their pharmacological,

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50

Frank, Priya V., Mahesha Manjunatha Poojary, Naral Damodara, and Chandrashekhar Chikkanna. "Synthesis and antimicrobial studies of some Mannich bases carrying imidazole moiety." Acta Pharmaceutica 63, no. 2 (2013): 231–39. http://dx.doi.org/10.2478/acph-2013-0016.

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3 Starting from 2-methyl-4-nitro-imidazole, new 5-(2-methyl- 4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thione () was synthesized and was subjected to Mannich reaction with appropriate amines to yield a new series of 3-substituted aminomethyl-5-(2-methyl-4-nitro-1-imidazomethyl)- 1,3,4-oxadiazole-2-thiones (4a-j). The structure of the title compounds was elucidated by elemental analysis and spectral data. The newly synthesized Mannich bases were screened for their antibacterial and antifungal activity. Many of these compounds exhibited potent antifungal activity.

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