Relevant bibliographies by topics / 1,3,4-Oxadiazoles

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic '1,3,4-Oxadiazoles'

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Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "1,3,4-Oxadiazoles"

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Vasiliev, N. V., Yu E. Lyashenko, A. E. Patalakha, and G. A. Sokolski. "Perfluoro 1,3,4-oxadiazoles." Journal of Fluorine Chemistry 58, no. 2-3 (August 1992): 375. http://dx.doi.org/10.1016/s0022-1139(00)80841-6.

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Vasiliev, N. V., Yu E. Lyashenko, A. E. Patalakha, and G. A. Sokolski. "Perfluoro-1,3,4-oxadiazoles." Journal of Fluorine Chemistry 65, no. 3 (December 1993): 227–31. http://dx.doi.org/10.1016/s0022-1139(00)80860-x.

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Heimann, Dominik, Corinna Lueg, Henk de Vries, Bastian Frehland, Dirk Schepmann, Laura H. Heitman, and Bernhard Wünsch. "Bioisosteric replacement of central 1,2,4-oxadiazole ring of high affinity CB2 ligands by regioisomeric 1,3,4-oxadiazole ring." MedChemComm 8, no. 8 (2017): 1697–705. http://dx.doi.org/10.1039/c7md00296c.

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Three pairs of regioisomeric 1,2,4- and 1,3,4-oxadiazoles were synthesized as selective CB2 ligands. Although the 1,3,4-oxadiazoles should have better physicochemical and pharmacokinetic properties, their CB2 affinity was reduced.
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Hanif, Muhammad, Khurram Shoaib, Muhammad Saleem, Nasim Hasan Rama, Sumera Zaib, and Jamshed Iqbal. "Synthesis, Urease Inhibition, Antioxidant, Antibacterial, and Molecular Docking Studies of 1,3,4-Oxadiazole Derivatives." ISRN Pharmacology 2012 (August 13, 2012): 1–9. http://dx.doi.org/10.5402/2012/928901.

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A series of eighteen 1,3,4-oxadiazole derivatives have been synthesized by treating aromatic acid hydrazides with carbon disulfide in ethanolic potassium hydroxide yielding potassium salts of 1,3,4-oxadiazoles. Upon neutralization with 1 N hydrochloric acid yielded crude crystals of 1,3,4-oxadiazoles, which were purified by recrystallization in boiling methanol. The synthesized 1,3,4-oxadiazoles derivatives were evaluated in vitro for their urease inhibitory activities, most of the investigated compounds were potent inhibitors of Jack bean urease. The molecular docking studies were performed by docking them into the crystal structure of Jack bean urease to observe the mode of interaction of synthesized compounds. The synthesized compounds were also tested for antibacterial and antioxidant activities and some derivatives exhibited very promising results.
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Dkhar, Gatphoh, M. Vijay Kumar, and B. C. Revanasiddappa. "CHLORAMINE-T MEDIATED SYNTHESIS OF 1,3,4-OXADIAZOLE DERIVATIVES." INDIAN DRUGS 57, no. 07 (October 8, 2020): 74–76. http://dx.doi.org/10.53879/id.57.07.12224.

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A series of new 1,3,4-oxadiazoles (3a-j) was synthesized by reacting Schiff’s bases (2a-j). The Schiff’s bases (2a-j) underwent selective cyclization with chloramine-T to yield the 1,3,4-oxadiazoles (3a-j). Newly synthesized compounds were characterized by spectral studies.
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Stewart, Scott, Xiao-Feng Wu, Zhiping Yin, Dennis Power, and Zechao Wang. "Synthesis of 1,3,4-Oxadiazoles via Annulation of Hydrazides and Benzene-1,3,5-triyl Triformate under Metal-Free Conditions." Synthesis 50, no. 16 (April 16, 2018): 3238–42. http://dx.doi.org/10.1055/s-0037-1609481.

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A new and efficient method for the synthesis of 1,3,4-oxadiazoles via the annulation of hydrazides with benzene-1,3,5-triyl triformate (TFBen) under metal-free conditions is reported. A broad range of hydrazides were transformed into the corresponding 1,3,4-oxadiazoles in good yields with excellent functional group tolerance.
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Rajak, Harish, Murli Dhar Kharya, and Pradeep Mishra. "Biologically Active 2,5-Disubstituted-1,3,4-Oxadiazoles." International Journal of Pharmaceutical Sciences and Nanotechnology 2, no. 1 (August 31, 2009): 390–406. http://dx.doi.org/10.37285/ijpsn.2009.2.1.2.

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There are vast numbers of pharmacologically active heterocyclic compounds in regular clinical use. The presence of heterocyclic structures in diverse types of compounds is strongly indicative of the profound effects such structure exerts on physiologic activity, and recognition of this is abundantly reflected in efforts to find useful synthetic drugs. The 1,3,4-oxadiazole nucleus has emerged as one of the potential pharmacophore responsible for diverse pharmacological properties. Medical Literature is flooded with reports of a variety of biological activities of 2,5-Disubstituted-1,3,4-oxadiazoles. The present work is an attempt to summarize and enlist the various reports published on biologically active 2,5-disubstituted-1,3,4-oxadiazoles.
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Mallikarjuna Reddy, Guda, Akkarapalli Muralikrishna, Venkatapuram Padmavathi, Adivireddy Padmaja, Thandaiah Krishna Tilak, and Chippada Appa Rao. "Synthesis and Antioxidant Activity of Styrylsulfonylmethyl 1,3,4-Oxadiazoles, Pyrazolyl/Isoxazolyl-1,3,4-oxadiazoles." Chemical and Pharmaceutical Bulletin 61, no. 12 (2013): 1291–97. http://dx.doi.org/10.1248/cpb.c13-00652.

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Ajani, Olayinka Oyewale, and King T. Iyaye. "Recent advances on oxadiazole motifs: Synthesis, reactions and biological activities." Mediterranean Journal of Chemistry 10, no. 5 (May 12, 2020): 418. http://dx.doi.org/10.13171/mjc10502005121200ooa.

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<p>1,3,4-oxadiazole derivatives have shown to have diverse and vast applications, from medicinal chemistry for the treatment and possible treatment of various ailments to its application in the industrial development when used as corrosion inhibitions and light emitting diodes. These diverse applications can be as a result of the numerous viable synthetic pathways illustrated in this review. 1,3,4-oxadiazoles can be synthesized in very high yields, using green approaches and having various life-changing applications. This review explores the various recent synthetic routes available for the development of 1,3,4-oxadiazoles and their biological activities.</p>
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Belen'kii, L. I., S. I. Luiksaar, I. S. Poddubnyi, and M. M. Krayushkin. "Novel syntheses of symmetrical 2,5-diaryl-1,3,4-oxadiazoles and 1,4-phenylenebis-1,3,4-oxadiazoles." Russian Chemical Bulletin 47, no. 11 (November 1998): 2238–45. http://dx.doi.org/10.1007/bf02494289.

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Dissertations / Theses on the topic "1,3,4-Oxadiazoles"

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Caneschi, Wiliam. "Síntese e avaliação biológica de 1,2,4- e 1,3,4-oxadiazóis." Universidade Federal de Juiz de Fora (UFJF), 2016. https://repositorio.ufjf.br/jspui/handle/ufjf/4086.

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Os heterociclos oxadiazólicos estão presentes em inúmeras estruturas com diversas propriedades biológicas, por esse motivo, o interesse nessa pesquisa. Desse modo, este trabalho encontra-se dividido em dois capítulos: o primeiro refere-se a síntese de oxadiazóis com intuito de verificar seu potencial biológico, enquanto o segundo, baseia-se no desenvolvimento de novas metodologias para síntese dos derivados 1,2,4 e 1,3,4oxadiazólicos. No primeiro capítulo, vinte e uma substâncias derivadas do heterociclo 1,2,4oxadiazólico foram obtidas por meio de reações de substituição nucleofilica de segunda ordem e trinta e dois novos derivados 1,3,4-oxadiazólicos foram obtidos a partir de reações do tipo Mannich. Os compostos foram testados quanto as suas propriedades citotóxicas e antibacteriana. De um modo geral, os derivados 1,2,4-oxadiazólicos não apresentaram interessantes atividades biológicas. Por outro lado, os regioisômeros 1,3,4- demonstraram um perfil de atividade interessante, sendo mais ativas que aquelas moléculas contendo o grupo piperazina alquilado com doze átomos de carbono. Para a atividade antitubercular, foi verificada uma melhor atividade para os 1,3,4-oxadiazóis alquilados com quatorze átomos de carbono. A busca cada vez maior por metodologias mais simples e eficientes na síntese de novas substâncias, propiciou, neste segundo capítulo, a síntese de uma série de derivados 1,2,4- e 1,3,4-oxadiazólicos obtidos por reações de aminocarbonilação catalisadas por paládio. Vários nucleófilos hidrazidas e amidoximas foram passíveis de reação com diferentes brometos de arila e monóxido de carbono produzido ex situ, em uma reação multicomponente, possibilitando a formação desses heterociclos em altos rendimentos. Essa metodologia se mostrou eficaz na marcação isotópica de ¹³C para diferentes compostos bem como permitiu a síntese do fármaco ataluren com rendimento global de 43%.
Oxadiazoles heterocycles are present in many structures with different biological properties, therefore, the interest in this research. So, this work is divided in two chapters: the first refers to the synthesis of these heterocycles in order to verify its biological potential, while the second is based on the development of new methodologies for synthesis of derivatives 1.2, 4 and 1,3,4-oxadiazoles. In the first chapter, twenty one 1,2,4-oxadiazoles derivatives were obtained by nucleophilic substitution reactions of second order and thirty two new 1,3,4oxadiazoles derivatives were obtained through Mannich-type reactions. The compounds were tested for their anticancer and antibacterial properties. In general, 1,2,4-oxadiazoles derivatives did not show interesting activity against the tested pathologies. On the other hand, 1,3,4-regioisomers demonstrated interesting activity profile, being most active those molecules containing the alkylated piperazine group with twelve carbons chain. For the antitubercular activity, a better activity was verified for the alkylated 1,3,4oxadiazoles with fourteen carbon chain. The search for efficient and simple methods for the synthesis of new molecules, allowed in the second chapter, the synthesis of a number of 1,2,4- and 1,3,4-oxadiazoles derivatives obtained by reactions palladium-catalyzed aminocarbonylation reactions. Various nucleophiles hydrazides and amidoximes were able of reaction with different aryl bromides and carbon monoxide produced ex situ in a multicomponent reaction, enabling the formation of such heterocycles in high yields. This methodology was effective for isotopic ¹³C labeling for different compounds as well as allowed the synthesis of the drug ataluren in an 43% overall yield.
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Cauliez, Pascal. "Composés issus de l'acide pyroglutamique : hétérocyclisations de diacyl hydrazines polysilylées en oxadiazoles-1,3,4 et pyrrolidino triazinones-1,2,4." Lille 1, 1989. http://www.theses.fr/1989LIL10169.

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La synthèse, la réactivité et quelques propriétés pharmaceutiques de différents hétérocycles dérivés de la structure pyroglutamique ont été étudiés. Les principaux résultats obtenus sont : 1) une amélioration de la synthèse du pyroglutamate de méthyle ; 2) une nouvelle méthode de synthèse des oxadiazoles-1,3,4 a partir de diacyl hydrazines via des intermédiaires silylés ; 3) l'application de cette méthode à des diacyl hydrazines dérivées de l'acide pyroglutamique ; 4) une cyclisation spécifique de n-acyl n-pyroglutamoyl-hydrazines trisilylées en oxadiazoles-1,3,4 ou en pyrrolidino triazinones-1,2,4 selon le catalyseur utilisé ; 5) une comparaison de différentes méthodes de carbamoylations des lactames; 6) l'application au pyroglutamate de méthyle et aux hétérocycles preparés de ces réactions de carbamoylation
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Caneschi, Wiliam. "Síntese e avaliação biológica de 1,3,4-oxadiazóis derivados da isoniazida." Universidade Federal de Juiz de Fora (UFJF), 2013. https://repositorio.ufjf.br/jspui/handle/ufjf/4646.

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Diversos análogos 1,3,4-oxadiazóis tem sido reportados na literatura uma vez que possuem grande espectro de atividade biológica, como: antiviral, antibacteriano, antitumoral, antioxidante, anti-inflamatório, anticonvulsivante, antimalarial, antifúngica e analgésica. Com o intuito de desenvolver moléculas ativas e seletivas a certas doenças, este trabalho descreve a síntese de derivados N-acilidrazonas e seus respectivos 2,3-diidro-1,3,4-oxadiazóis, o que resultou na obtenção de vinte e sete derivados inéditos, dentre eles: nove derivados de Nacilidrazonas e dezoito derivados 2,3-diidro-1,3,4-oxadiazóis. Foram obtidos vinte e oito derivados N-acilidrazonas a partir de uma reação de adição de aldeídos aromáticos e heteroaromáticos com a isoniazida. Para a obtenção das N-acilidrazonas com cadeia longa, foi proposto, inicialmente, a alquilação do 4-hidroxibenzaldeído com haletos de alquila com: 1-cloroexano, 1-cloro-octano, 1-bromononano, 1-clorodecano, 1-clorododecano, 1-lorotetradecano e 1-bromo-propargila. Foi proposta também a síntese de dois derivados sulfonados, sintetizados pela mesma metodologia de alquilação com os cloretos de mesila e tosila. Em seguida, os aldeídos alquilados e sulfonados sintetizados e dezenove aldeídos comerciais foram condensados a isoniazida gerando os derivados N-acilidrazonas, que por sua vez, foram ciclizados, em reação com anidrido acético, que gerou vinte e sete derivados 2,3-diidro-1,3,4-oxadiazólicos. As estruturas dos compostos obtidos foram elucidadas por espectroscopia na região do infravermelho, RMN de 1H e de 13C, técnicas de RMN 2D, espectrometria de massas. Os análogos oxadiazólicos foram submetidos a teste de citotoxicidade, antibacteriano, antioxidante e antimalarial. Os compostos se mostraram bastantes ativos contra células cancerígenas, com índices de seletividade superiores ao composto padrão utilizado.
Several analogs 1,3,4-oxadiazoles have been reported in the literature due to wide range biological activity, such as: antiviral, antibacterial, antitumoral, antioxidant, anti-inflammatory, anticonvulsivant, antimalarial, antifungal e analgesic activity. With the aim to develop molecules active and selective for some illness, this work describe the synthesis of some N-acyl-hydrazones derivatives and the respective 2,3-dihydro-1,3,4-oxadiazoles, that resulted the obtainment twenty seven inedited derivatives, among them: nine N-acyl-hydrazones derivatives and eighteen 2,3-dihydro-1,3,4-xadiazoles derivatives. At this work were obtainment twenty e eight N-acylhydrazones derivatives through the addition reaction of aromatics and heteroaromatics aldehydes with isoniazid. For the obtainment of N-acyl-hydrazones of long chain, the 4-hydroxybenzaldehyde was alkylated with several alkyl halides: 1-chlorohexane, 1-chlorooctane, 1-bromononane, 1-chlorodecane, 1-chlorododecane, 1-hlorotetradecane and 1-bromopropargyl. It was also proposed the synthesis of two sulfa derivatives, synthesized by the same alkylation methodology with the mesyl and tosyl chloride. These alkylated aldehydes and nineteen commercials aldehydes were condensed to the isoniazid that gave the N-acyl-hydrazones derivatives, which in turn were cyclized to obtain the 2,3-dihydro-1,3,4-oxadiazoles derivatives in reaction with acetic anhydride. The structures of the compounds were elucidated by in infrared, ¹H NMR, ¹³C NMR, 2D NMR techniques, mass spectrometry. The oxadiazoles analogs were submitted to citotoxicity, antibacterial, antioxidant and antimalarial activity. The compounds showed great activity against tumor cells, with selectivity index higher than standard compound used.
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Rasras, Anas [Verfasser], and Sabine [Akademischer Betreuer] Amslinger. "Synthesis of biologically active enones: 2,3-dihydro-1,3,4-oxadiazoles, alpha-X-cyclopentenones and attempts towards limnophilaspiroketone and zerumbone / Anas Rasras. Betreuer: Sabine Amslinger." Regensburg : Universitätsbibliothek Regensburg, 2015. http://d-nb.info/1092188061/34.

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Chang, Wei-En, and 張維恩. "The synthesis and the fluorescence spectra of 1,3,4-oxadiazoles and related compounds." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/33586363637803609692.

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碩士
國立中央大學
化學工程與材料工程研究所
91
1,3,4-oxadiazoles were prepared by 1,2-dibenzoylhydrazines and cyclodehydration in solution phase involving reagents (reagents = PPA、POCl3、BF3‧Et2O).Use suited cyclo-dehydration for each 1,2-dibenzoylhydrazine. The product which PET and ethylene glycol reacted to could be handle to be 1,2-dibenzoylhydrazine and cyclodehydration by PPA. It can be success to form 1,3,4-oxadiazole. The strong donor substitutent not only was shift the wavelength of fluorescent to longer wavelength but also increased the maximum strength. The compounds containing double 1,3,4-oxadiazole ring or double bonds were as same as the compounds containing strong donor substitutent. The compounds containing nitro substitutent didn’t affect the maximum uv absorption and The fluorescent wavelength very much,but shown very weak fluorescent strength. The fluorescent wavelength of the 1,3,4-oxadiazole compounds containing strong donor or acceptor substitutent didn’t fit the value caculated by the Pestemer rule(coefficient is 2.5).However,the fluorescent wavelength of the 1,3,4-oxadiazole compounds without substitutent or with weak or acceptor substitutent was equal to the value. Therefore,Pestemer rule was applied to the 1,3,4-oxadiazoles without substitutent or with weak or acceptor substitutent. Reactive dye could form a covalent bond with cotton in all saline solution. The product by coupling J-acid with triazine could react with 1,3,4-oxadiazole containing amino substitutent to form the dye containing 1,3,4-oxadiazoyl substitutent. The fluorscent of dye was lower than 1,3,4-oxadiazole containing amino substitutent,but it was higher than the dye by coupling J-acid with trazine.
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Solařová, Hana. "Fosfinoferrocenové amidy a hydrazidy." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-297652.

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Title: Phosphinoferrocene amides and hydrazides Author: Hana Solařová Department: Department of Inorganic Chemistry Supervisor: doc. RNDr. Petr Štěpnička, Ph.D. Abstract: While studying functionalized phosphinoferrocene ligands, we recently turned to phosphinoferrocene carboxamides. These donors already proved to be versatile ligands for coordination chemistry and catalysis. This led us to synthesize and study the archetypal representative, 1'-(diphenylphosphino)-1-carbamoylferrocene (5), and the corresponding hydrazide 6. PPh2 COOH Fe Hdpf PPh2 CONH2 Fe 5 PPh2 CONHNH2 Fe 6 This work describes the preparation of primary amide 5 and hydrazide 6 from 1'- (diphenylphosphino)-1-ferrocenecarboxylic acid (Hdpf) via the corresponding acylbenzo- triazole derivative. The hydrazide was alternatively obtained from Hdpf methylester and hydrazine hydrate. Both newly synthesized compounds were characterized by spectroscopic methods (NMR, IR, and MS) and elemental analysis, and their crystal structures were determined by single-crystal X-ray crystallography. The amide was further utilized in the preparation of several palladium complexes, which were characterized in a similar manner including X-ray crystallography. One palladium complex was obtained also from the hydrazide. However, the hydrazide was used mainly as a...
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Book chapters on the topic "1,3,4-Oxadiazoles"

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Simmons, Kirk A., Blaik P. Halling, Robert J. Schmidt, and Debra A. Witkowski. "2-(2′-Nitrophenyl)-1,3,4-oxadiazoles." In ACS Symposium Series, 236–46. Washington, DC: American Chemical Society, 1991. http://dx.doi.org/10.1021/bk-1991-0443.ch019.

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Behr, Lyell C. "1,3,4-Oxadiazoles: Ring Index 85." In Chemistry of Heterocyclic Compounds: A Series Of Monographs, 263–82. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186787.ch10.

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Brovarets, V. S., O. P. Mityukhin, A. V. Golovchenko, and B. S. Drach. "Syntheses of Fluorinated 1,3-Oxazoles, 1,3,4-Oxadiazoles, 1,3,4-Thiadiazoles, and Oxazolo[4,5-d]pyrimidines." In ACS Symposium Series, 281–89. Washington, DC: American Chemical Society, 2009. http://dx.doi.org/10.1021/bk-2009-1003.ch013.

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Walczak, Krzysztof Z., and Wojciech Szczepankiewicz. "1,3,4-Oxadiazoles." In Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. Elsevier, 2020. http://dx.doi.org/10.1016/b978-0-12-818655-8.00019-6.

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Suwiński, J., and W. Szczepankiewicz. "1,3,4-Oxadiazoles." In Comprehensive Heterocyclic Chemistry III, 397–466. Elsevier, 2008. http://dx.doi.org/10.1016/b978-008044992-0.00506-x.

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Hill, John. "1,3,4-Oxadiazoles." In Comprehensive Heterocyclic Chemistry II, 267–87. Elsevier, 1996. http://dx.doi.org/10.1016/b978-008096518-5.00084-8.

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Curtis, A. D. M. "From 1,3,4-Oxadiazoles." In Five-Membered Hetarenes with Three or More Heteroatoms, 1. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-013-00885.

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Stanovnik, B., and J. Svete. "Synthesis from 1,3,4-Oxadiazoles." In Five-Membered Hetarenes with Two Nitrogen or Phosphorus Atoms, 1. Georg Thieme Verlag KG, 2002. http://dx.doi.org/10.1055/sos-sd-012-00172.

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Heydt, H. "Of 2,5-Dihydro-1,3,4-oxadiazoles." In Heteroatom Analogues of Aldehydes and Ketones, 1. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-027-00779.

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"Product Class 8: 1,3,4-Oxadiazoles." In Category 2, Hetarenes and Related Ring Systems, edited by Storr and Gilchrist. Stuttgart: Georg Thieme Verlag, 2004. http://dx.doi.org/10.1055/sos-sd-013-00323.

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Conference papers on the topic "1,3,4-Oxadiazoles"

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Slovesnova, N. V., I. S. Kovalev, D. S. Kopchuk, G. V. Zyryanov, O. N. Chupakhin, and A. Yu Petrov. "pH-color changing of 1,3,4-oxadiazoles." In PROCEEDINGS OF INTERNATIONAL CONFERENCE ON RECENT TRENDS IN MECHANICAL AND MATERIALS ENGINEERING: ICRTMME 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0018568.

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Yarovenko, V., I. Zavarzin, and M. Krayushkin. "Convenient synthesis of 1,2,5-(1,3,4)-oxadiazolyl-1,2,4-oxadiazoles." In The 1st International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 1997. http://dx.doi.org/10.3390/ecsoc-1-02051.

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Martins, Bruna Simões, Elisiane Frantz Heck, Caroline Raquel Bender, Wolmar A. Severo Filho, Antonio L. Braga, Oscar E. Dorneles Rodrigues, and Luciano Dornelles. "Synthesis of 1,3,4-oxadiazoles derivatives from -amino acids and acyl hydrazides using microwave irradiation." In 14th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0364-1.

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Rao, A. Tejeswara, A. Jaya Shree, A. Vijay Kumar Reddy, and Grigory V. Zyryanov. "Synthesis and molecular properties of novel fluoroquinolone citrate conjugates linked to 1,3,4-oxadiazoles as antibacterial and anticancer agents." In PROCEEDINGS OF INTERNATIONAL CONFERENCE ON RECENT TRENDS IN MECHANICAL AND MATERIALS ENGINEERING: ICRTMME 2019. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0023473.

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