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Journal articles on the topic '1,3,4-thiadiazole'

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Published: 4 June 2021

Last updated: 12 February 2022

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1

Journal, Baghdad Science. "Synthesis of some Schiff's bases derivatives from aminoazo compounds." Baghdad Science Journal 4, no. 3 (2007): 416–19. http://dx.doi.org/10.21123/bsj.4.3.416-419.

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Reaction of,2- [( 4- amio phenyl ) diazenyl] 1,3,4- thiadiazole -5- thiol (S1) with p- chlorobenzeldehyde,3,4 – dimethoxy benzaldehyde and pyrrol-2- carbonxaldehyde gave -5- [{4-(4-chlorobenzylidene amino) phenyl} diezenyl]-1,3,4- thiadiazole-2- thiol (S2),5-[{ 4-[(3,4- dimethoxybenzyldene )amino phenyl ] diazenyl)-1,3,4- thiadiazole-2-thiol,(S3) and -5- [4-(1,H – pyrrol -2- yl- methylene)amino phenyl] diazenyl)-1,3,4- thiadiazole-2- thiol (S4) respectively as schiff's bases compounds. On the same route-2-[(4-amino-1- naphthyl ) diazenyl] -1,3,4- thiadiazole -5- thiol (S5) reacts with –p- chlo

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2

Journal, Baghdad Science. "Preparation of some azo compounds by diazotization and coupling of 2- amino -5 – thiol -1,3,4- thiadizaole." Baghdad Science Journal 4, no. 2 (2015): 271–75. http://dx.doi.org/10.21123/bsj.4.2.271-275.

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2- amino -5- thiol-1,3,4- thiadiazole (S1) was prepared by cyclic locking of thiosemicarbazide in the presence of anhydrous sodium carbonate and CS2. diazotization of (S1) compound gave diazonium salt (S2) that reacts with different activated aromatic compounds to get the following azo compounds ,2 [(4- aminophenyl) diazenyl ] 1,3,4- thiazdiazole-5- thiol (S3) ,2-[4-amino- 1-naphthyl diazenyl] -1,3,4 – thiazdiazole-5-thiol (S4) , 3-amino-4-[(5- mercapto -1,3,4- thiadiazole -2-yl) diazenyl ] phenol(S5) ,1-[(5-mercapto-1,3,4-thiadiazole-2-yl) diazenyl] -2-naphthol (S6) , 5-{[4-(dimethylamino) ph

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3

Zhao, Yuxiang, Peter J. McCarthy, and Cyril Párkányi. "Synthesis and In Vitro Evaluation of Novel Acyclic and Cyclic Nucleoside Analogs with a Thiadiazole Ring." ISRN Organic Chemistry 2013 (March 5, 2013): 1–10. http://dx.doi.org/10.1155/2013/159164.

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The synthesis of six thiadiazole nucleoside analogs is reported: 5-diacetylamino-1,2,4-thiadiazol-3-one (1), 5-amino-2- (tetrahydrofuran-2-yl)-1,2,4-thiadiazol-3-one (2), 5-amino-3-[(2′-hydroxyethoxy)methyl]-1,3,4-thiadiazol-2-one (3), 5-amino-3-(4′-hydroxy-2′-hydroxymethyl-butyl)-1,3,4-thiadiazole-2-thione (4), (R)-5-amino-3-(2′,3′-dihydroxypropyl)-1,3,4-thiadiazole-2-thione (5), and (S)-5-amino-3-(2′,3′-dihydroxypropyl)-1,3,4-thiadiazole-2-thione (6). The synthesis, characterization, and properties of these new synthesized thiadiazole derivatives are discussed. A dimerization of 5-amino-3H-1

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4

Journal, Baghdad Science. "Synthesis and Characterization of Five, Sevene Heterocyclic Membered Rings." Baghdad Science Journal 10, no. 3 (2013): 803–17. http://dx.doi.org/10.21123/bsj.10.3.803-817.

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New compounds containing heterocyclic units have been synthesized. These compounds include 2-amino 5- phenyl-1,3,4-thiadiazole (1) as starting material to prepare the Schiff bases 2N[3-nitrobenzylidene -2 hydroxy benzylidene and 4-N,N-dimethyl aminobenzylidene] -5-phenyl-1,3,4-thiadiazole (2abc) , 2N[3-nitrophenyl, 2-hydroxyphenyl or 4-N,N-dimethylaminophenyl] 3-]2-amino-5-phenyl-1,3,4-thiadiazole]-2,3-dihydro-[1,3]oxazepine-benzo-4,7-dione] (3abc), 2N[3-nitrophenyl,2-hydroxyphenyl,4-N,N-dimethylaminophenyl]-3-[2-amino-5-phenyl-1,3,4-thiadiazole-2-yl]-2,3-dihydro-[1,3]oxazepine-4,7-dione[(4abc

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5

Plotnikova, M. D., A. B. Shein, M. G. Shcherban`, and A. D. Solovyev. "The study of thiadiazole derivatives as potential corrosion inhibitors of low-carbon steel in hydrochloric acid." Bulletin of the Karaganda University. "Chemistry" series 103, no. 3 (2021): 93–102. http://dx.doi.org/10.31489/2021ch3/93-102.

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The inhibition effect of series of thiadiazole derivatives against the corrosion of mild steel in 15 % HCl was studied by weight-loss method and electrochemical measurements. The experiments were performed on steel St3 at 293 K, the exposure time of the samples in solution for weight-loss measurements was 24 h. Potentiodynamic polarization curves were obtained in a typical three electrode cell with the help of electrochemical measuring complex SOLARTRON 1280 C. A scan rate was 1 mV⋅s-1 and a measurement point was taken every 0.2 s. 2-aminothiazole, 5-amino-1,3,4-thiadiazole-2-thiol, 2-amino-1,

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6

Tyutina, Marina A., Tatyana V. Kudayarova, and Elena A. Danilova. "PRODUCTS OF INTERACTION BETWEEN 2,5-DIAMINO- 1,3,4-THIADIAZOLE AND p-AMINOBENZALDEHYDE." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENIY KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 59, no. 5 (2018): 16. http://dx.doi.org/10.6060/tcct.20165905.5351.

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5-Amino-2N-benzylidene-4'-amino-1,3,4-thiadiazole and 2,5 bis (N-benzylidene-4'-amino) - 1,3,4-thiadiazole was synthesized by interaction between 2,5-diamino-1,3,4-thiadiazole and p –ami-nobenzaldehyde in ethanol environment. The structure was established on data of mass spectrometry, the elemental analysis, UV-Vis, IR, 1H NMR spectroscopy. An electronic and geometrical structure of the synthesized compounds was studied by methods of quantum chemistry.

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7

Journal, Baghdad Science. "SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME (2-AMINO-5-THIOL-1, 3, 4-THIADIAZOLE DERIVATIVES." Baghdad Science Journal 4, no. 1 (2007): 89–94. http://dx.doi.org/10.21123/bsj.4.1.89-94.

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Five derivatives of thiadiazole were prepared with aldehydes and alkyl halides, compoundA: 2-amino-5-thiol-1,3,4- thiadiazole, compound B :2-(o-hydroxybenzylidine)amino-5-thiol-1,3,4-thiadiazole, compoundC: 2(2-butan-lidine)amino-5-thiol-1,3,4-thiadiazole, compound E: 2- amino-5-(2-Propanylthio)-1,3,4-thiadiazol) and compound F:2(o-chlorobenzylamino)-5-(2-propanyl thio)-1,3,4 thiadiazol. All prepared compounds were diagnosed by (IR) and (UV) Spectroscopy. All of those compounds were screened for their anti-microbial activity in vitro. The results show that most of the compounds A, B, C exhibit

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8

Schäfer, W., U. Rosenfeld, H. Zaschke, H. Stettin, and H. Kresse. "Kristallin-flüssige 1,3,4-Thiadiazole. II [1]. 1,3,4-Thiadiazole mit Cyclohexanstrukturfragmenten." Journal für Praktische Chemie 331, no. 4 (1989): 631–36. http://dx.doi.org/10.1002/prac.19893310413.

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9

Shi, Da-Hua, Hui-Long Zhu, Yu-Wei Liu, et al. "Synthesis and Evaluation of 5-Benzyl-1,3,4-Thiadiazole Derivatives as Acetylcholinesterase Inhibitors." Journal of Chemical Research 41, no. 11 (2017): 664–67. http://dx.doi.org/10.3184/174751917x15094552081242.

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Three novel 5-benzyl-1,3,4-thiadiazole derivatives were synthesised starting from phenylacetic acid derivatives. These compounds were characterised by NMR, HRMS and single-crystal X-ray diffraction analysis. 2-Pyrrolidyl-5-[2-(4-bromophenyl)methyl]-1,3,4-thiadiazole showed moderate acetylcholinesterase-inhibition activity with a 50% inhibitory concentration value of 33.16 μM. 2-Pyrrolidyl-5-[2-(4-bromophenyl)methyl]-1,3,4-thiadiazole and acetylcholinesterase docking was demonstrated using the Molecular Operating Environment program.

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10

Ila, Reshmi Dani, Surya Pratap Verma, and G. Krishnamoorthy. "The origin of the longer wavelength emission in 2-(4-fluorophenylamino)-5-(2,4-dihydroxybenzeno)-1,3,4-thiadiazole and its analogue 2-phenylamino-5-(2-hydroxybenzono)-1,3,4-thiadiazole." Photochemical & Photobiological Sciences 19, no. 6 (2020): 844–53. http://dx.doi.org/10.1039/c9pp00490d.

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11

Han, Jie, Feng Yan Zhang, and Juan Yu Wang. "Synthesis and Mesomorphic Property of 2,5-Aryl-1,3,4-Oxadiazole/Thiadiazole Derivatives Bearing a Terminal Thiophene Unit." Key Engineering Materials 428-429 (January 2010): 52–56. http://dx.doi.org/10.4028/www.scientific.net/kem.428-429.52.

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The synthesis and characterization of a series of heterocyclic compounds 2a-2d based on 1,3,4-oxadiazole/ thiadiazole, furan and thiophene units are reported. The thermal behaviors of these compounds were investigated by means of differential scanning calorimetry (DSC), polarizing optical microscopy (POM) and thermogravimetric analysis (TGA). The 1,3,4-thiadiazole derivative 2b exhibited enantiotropic smectic C and A mesophases with wide temperature range and good thermal stability, while all of the other compounds did not show liquid crystalline behaviors. The results indicate that 1,3,4-thia

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12

Suvorova, Yu V., E. A. Petukhova, E. A. Danilova, and D. V. Tyurin. "Synthesis and Properties of Bisthiadiazoles with Ethyl and Butyl Spacers." Liquid Crystals and their Application 20, no. 4 (2020): 27–34. http://dx.doi.org/10.18083/lcappl.2020.4.27.

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This article is devoted to a selection of the most effective preparative method for the synthesis of bis(5-amino-1,3,4-thiadiazole-2-yl)alkanes. These compounds are binuclear diamines consisting of symmetrical 1,3,4-thiadiazole fragments connected by alkyl spacers of various lengths. The structures of the obtained compounds were determined by IR spectroscopy, mass-spectrometry and elemental analysis. The possibility of using these molecules as precursors for the synthesis of macroheterocyclic compounds with expended coordination cavity consisting of six small cycles was demonstrated. Optimal s

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13

Praveen, Aletti S., Hemmige S. Yathirajan, Manpreet Kaur, et al. "Different patterns of supramolecular assembly in constitutionally similar 6-arylimidazo[2,1-b][1,3,4]thiadiazoles." Acta Crystallographica Section C Structural Chemistry 70, no. 9 (2014): 920–26. http://dx.doi.org/10.1107/s2053229614018762.

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Four imidazo[2,1-b][1,3,4]thiadiazoles containing a simply-substituted 6-aryl group have been synthesized by reaction of 2-amino-1,3,4-thiadiazoles with bromoacetylarenes using microwave irradiation and brief reaction times. 6-(2-Chlorophenyl)imidazo[2,1-b][1,3,4]thiadiazole, C10H6ClN3S, (I), 6-(2-chlorophenyl)-2-methylimidazo[2,1-b][1,3,4]thiadiazole, C11H8ClN3S, (II), 6-(3,4-dichlorophenyl)imidazo[2,1-b][1,3,4]thiadiazole, C10H5Cl2N3S, (III), and 6-(4-fluoro-3-methoxyphenyl)-2-methylimidazo[2,1-b][1,3,4]thiadiazole, C12H10FN3OS, (IV), crystallize withZ′ values of 2, 1, 1 and 2 respectively.

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14

Alminderej, Elganzory, El-Bayaa, Awad, and El-Sayed. "Synthesis and Cytotoxic Activity of New 1,3,4-Thiadiazole Thioglycosides and 1,2,3-Triazolyl-1,3,4-Thiadiazole N-glycosides." Molecules 24, no. 20 (2019): 3738. http://dx.doi.org/10.3390/molecules24203738.

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New 1,3,4-thiadiazole thioglycosides linked to substituted arylidine systems were synthesized via glycosylation of the prepared 1,3,4-thiadiazole thiol compounds. Click strategy was also used for the synthesis of new 1,3,4-thiadiazole and 1,2,3-triazole hybrid glycosides by reaction of the acetylenic derivatives with different glycosyl azids followed by deacetylation process. The cytotoxic activities of the prepared compounds were studied against HCT-116 (human colorectal carcinoma) and MCF-7 (human breast adenocarcinoma) cell lines using the MTT assay. The results showed that the key thiadiaz

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15

Ismailova, D. S., R. Ya Okmanov, A. A. Ziyaev, Kh M. Shakhidoyatov, and B. Tashkhodjaev. "N-(5-Benzylsulfanyl-1,3,4-thiadiazol-2-yl)-2-(piperidin-1-yl)acetamide." Acta Crystallographica Section E Structure Reports Online 70, no. 3 (2014): o241. http://dx.doi.org/10.1107/s160053681400213x.

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The title compound, C16H20N4OS2, was synthesized by the reaction of 2-benzylsulfanyl-5-chloroacetamido-1,3,4-thiadiazole and piperidine in a 1:2 ratio. The planes of the acetamide and 1,3,4-thiadiazole units are twisted by 10.8 (4)°. The thiadiazole S atom and the acetamide O atom aresyn-oriented due to a hypervalent S...O interaction of 2.628 (4) Å. In the crystal, molecules form centrosymmetric dimersviaN—H...N hydrogen bonds. These dimers are further connected by C—H...O interactions into (100) layers.

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16

Rakhmonov, R., Sh Sharipov, M. Odilzoda, B. Safarov, A. Kobilzoda, and A. Abdurakhmonov. "SYNTHESIS AND FUNCTIONALIZATION OF SOME PARA-R-PHENYLIMIDAZO[2,1-B][1,3,4]- THIADIAZOLE DERIVATIVES." East European Scientific Journal 1, no. 4(68) (2021): 54–61. http://dx.doi.org/10.31618/essa.2782-1994.2021.1.68.15.

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The article describes the synthesis of new modifications of derivatives of 6-phenyl-, 6-piodophenyl- and 6-p-bromophenylimidazo[2,1-b][1,3,4]-thiadiazoles - N -((6-(4-iodophenyl)-2-R-imidazo[2,1-b][1,3,4]-thiadiazol-5-yl)methyl)-alkyl/ heterylamine based on the Mannich reaction, bromination 2((ethylsulfonyl)methyl)-6-phenylimidazo[2,1-b][1,3,4]-thiadiazole and the structure of the resulting compounds was established on the basis of IR spectroscopy. It was shown that the presence of substituents at the 2-nd position of the thiadiazole fragment and substituents at the 5th and 6th positions of th

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17

Janowska, Sara, Agata Paneth, and Monika Wujec. "Cytotoxic Properties of 1,3,4-Thiadiazole Derivatives—A Review." Molecules 25, no. 18 (2020): 4309. http://dx.doi.org/10.3390/molecules25184309.

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During recent years, small molecules containing five-member heterocyclic moieties have become the subject of considerable growing interest for designing new antitumor agents. One of them is 1,3,4-thiadiazole. This study is an attempt to collect the 1,3,4-thiadiazole and its derivatives, which can be considered as potential anticancer agents, reported in the literature in the last ten years.

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18

Prasad, Malavattu G., Chapala V. Lakshmi, Naresh K. Katari, and Manojit Pal. "Lemon Juice as a Biocatalyst Under Ultrasound Irradiation: Synthesis and Pharmacological Evaluation of 2-amino 1,3,4-thiadiazoles." Anti-Cancer Agents in Medicinal Chemistry 20, no. 11 (2020): 1379–86. http://dx.doi.org/10.2174/1871520620666200409143513.

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Background: The 2-amino 1,3,4-thiadiazole framework has attracted considerable interest because of its prevalence in compounds possessing a wide range of pharmacological properties including anticancer/antitumor activities. Though a number of methods have been reported for the synthesis of this class of compounds, some of them are not straightforward, inexpensive and environmentally friendly. Objective: To synthesize 2-amino-1,3,4-thiadiazole derivatives that could act as potential anticancer agents. Methods: The use of lemon juice as an inexpensive and readily available biocatalyst was explor

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19

Bentiss, Fouad, Moha Outirite, Michel Lagrenée, Mohamed Saadi та Lahcen El Ammari. "Aquabis[2,5-bis(pyridin-2-yl)-1,3,4-thiadiazole-κ2N2,N3](trifluoromethanesulfonato-κO)copper(II) trifluoromethanesulfonate". Acta Crystallographica Section E Structure Reports Online 68, № 4 (2012): m360—m361. http://dx.doi.org/10.1107/s1600536812008732.

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2,5-Bis(pyridin-2-yl)-1,3,4-thiadiazole (denotedL) has been found to act as a bidentate ligand in the monomeric title complex, [Cu(CF3O3S)(C12H8N4S)2(H2O)](CF3O3S). The complex shows a distorted octahedrally coordinated copper(II) cation which is linked to two thiadiazole ligands, one water molecule and one trifluoromethanesulfonate anion. The second trifluoromethanesulfonate anion does not coordinate the copper(II) cation. Each thiadiazole ligand uses one pyridyl and one thiadiazole N atom for the coordination of copper. The N atom of the second non-coordinating pyridyl substituent is found o

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20

Yadav, M., Sumit Kumar, and Debasis Behera. "Inhibition Effect of Substituted Thiadiazoles on Corrosion Activity of N80 Steel in HCl Solution." Journal of Metallurgy 2013 (April 18, 2013): 1–14. http://dx.doi.org/10.1155/2013/256403.

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The inhibition effect of some prepared compounds, namely, thiadiazole derivatives, on N80 steel corrosion in 15% HCl solutions has been studied by using the weight loss, electrochemical polarization, and electrochemical impedance spectroscopy techniques. It was found that the inhibition efficiency of the thiadiazole derivatives, namely, 2-amino-5-(4-methoxyphenyl)-1,3,4-thiazole (AMPT), 2-amino-5-phenyl-1,3,4-thiazole (APT), and 2-amino-5-(4-chlorophenyl)-1,3,4-thiazole (ACPT), increases with the increase in concentration. Inhibition efficiency follows the order AMPT > APT > ACPT. The ef

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21

Lynch, Daniel E. "2-Amino-5-methyl-1,3,4-thiadiazole and 2-amino-5-ethyl-1,3,4-thiadiazole." Acta Crystallographica Section C Crystal Structure Communications 57, no. 10 (2001): 1201–3. http://dx.doi.org/10.1107/s0108270101011817.

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22

Patel, Navin B., Rahul B. Parmar, and Hetal I. Soni. "Lewis Acid Promoted, One-Pot Synthesis of Fluoroquinolone Clubbed 1,3,4-Thiadiazole Motifs under Microwave Irradiation: Their Biological Activities." Current Microwave Chemistry 7, no. 1 (2020): 60–66. http://dx.doi.org/10.2174/2213335606666191016111642.

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Background: A Lewis acid promoted efficient and facile procedure for one-pot synthesis of a novel series of fluoroquinolone clubbed with thiadiazoles motifs under microwave irradiation is described here. This technique has more advantages such as high yield, a clean procedure, low reaction time, simple work-up and use of Lewis acid catalyst. Objective: Our aim is to generate a biologically active 1,3,4- thiadiazole ring system by using a onepot synthesis method and microwave-assisted heating. High yield and low reaction time were the main purposes to synthesize bioactive fluoroquinolone clubbe

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23

Mastalerz, Harold, Taj Mohammad, and Martin S. Gibson. "A 2-methylthio-3,5-diaryl-1,3,4-thiadiazolium cation; its reactions, and further exploration of the chemistry of 2-alkyl-3,5-diaryl-1,3,4-thiadiazolium cations." Canadian Journal of Chemistry 65, no. 12 (1987): 2713–16. http://dx.doi.org/10.1139/v87-450.

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Activation of a representative 3,5-diaryl-1,3,4-thiadiazole-2-thione by thione S-methylation gives a cation that is readily susceptible to nucleophilic substitution. Reactions with diethyl malonate, ethyl acetoacetate, acetylacetone, cyclopentan-1,3-dione, or 3-ethylrhodanine under basic conditions lead to β,β-disubstituted methine bases and (or) β-substituted methine bases in cases where deacetylation occurs under the reaction conditions. This cation and the 2-alkyl-3,5-diaryl-1,3,4-thiadiazolium cation are convenient sources of a series of neutral and cationic dyes containing the 1,3,4-thiad

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24

Wang, Xi-Cun, Man-Gang Wang, Zhi Yang, Zheng-Jun Quan, Fang Wang, and Zheng Li. "A practical and rapid synthesis of 2-aryloxymethylene-6-arylimidazo [2,1-b][1,3,4]thiadiazole in aqueous media." Journal of Chemical Research 2005, no. 11 (2005): 744–46. http://dx.doi.org/10.3184/030823405774909450.

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A practical and rapid procedure is reported for the synthesis of a variety of 2-aryloxymethylene-6-arylimidazo[2,1-b][1,3,4]thiadiazole 3a–m by condensation reaction of 2-amino-5-aryloxymethylene-1,3,4-thiadiazole 1a–g with ω-bromoacetophenone derivatives 2a–b in aqueous media under microwave irradiation and yielded a series of novel compounds. The procedure is simple and the yields are good to excellent.

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25

Dutta, B. C., K. K. Das, and B. N. Goswami. "Cycloaddition Reaction: Synthesis of 5-Substituted 1,3,4-Thiadiazolo[3,2-a]pyrimidin-6-one." Journal of Chemical Research 23, no. 1 (1999): 36–37. http://dx.doi.org/10.1177/174751989902300124.

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Mague, Joel T., Mehmet Akkurt, Shaaban K. Mohamed, Ahmed M. M. El-Saghier, and Mustafa R. Albayati. "2,2′-[(1,3,4-Thiadiazole-2,5-diyl)bis(sulfanediyl)]diacetonitrile." Acta Crystallographica Section E Structure Reports Online 69, no. 12 (2013): o1855. http://dx.doi.org/10.1107/s1600536813032194.

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In the title compound, C6H4N4S3, the 1,3,4-thiadiazole ring is essentially planar, with an r.m.s. deviation of 0.001 Å. The two N—C—S—C torsion angles in the molecule are −23.41 (15) and 0.62 (14)°. One acetonitrile group is above the plane of the 1,3,4-thiadiazole ring and the other is below it, indicatingsynandantiorientations. In the crystal, C—H...N hydrogen bonds link the molecules into ribbons along [010].

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27

Radovanović, Milan, Marija Petrović Mihajlović, and Milan Antonijević. "2-Amino-5-ethyl-1,3,4-thiadiazole as inhibitor of brass corrosion in 3% NaCl." Metallurgical and Materials Engineering 22, no. 1 (2016): 51–60. http://dx.doi.org/10.30544/140.

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The electrochemical behaviour of brass and anticorrosion effect of 2-amino-5- ethyl-1,3,4-thiadiazole (AETD) in chloride solution was investigated using electrochemical techniques. Results show that inhibition efficiency depended on inhibitor concentration and immersion time of brass electrode in inhibitor solution. Mechanism of brass corrosion inhibition by 2-amino-5-ethyl-1,3,4-thiadiazole includes adsorption of inhibitor on active sites on electrode surface. Adsorption of AETD in 3% NaCl solution obeys Langmuir adsorption isotherm.

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Aliabadi, Alireza. "1,3,4-Thiadiazole Based Anticancer Agents." Anti-Cancer Agents in Medicinal Chemistry 16, no. 10 (2016): 1301–14. http://dx.doi.org/10.2174/1871520616666160628100936.

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29

Le, Van-Duc, Charles W. Rees, and Sivaprasad Sivadasan. "Synthesis of 1,3,4-thiadiazole oligomers." Journal of the Chemical Society, Perkin Transactions 1, no. 13 (May 30, 2002): 1543–47. http://dx.doi.org/10.1039/b203705j.

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30

Burnett, Marianne E., Hannah M. Johnston, and Kayla N. Green. "Structural characterization of the aquaporin inhibitor 2-nicotinamido-1,3,4-thiadiazole." Acta Crystallographica Section C Structural Chemistry 71, no. 12 (2015): 1074–79. http://dx.doi.org/10.1107/s2053229615021130.

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Nicotinamides are a class of compounds with a wide variety of applications, from use as antimicrobial agents to inhibitors of biological processes. These compounds are also cofactors, which are necessary components of metabolic processes. Structural modification gives rise to the activities observed. Similarly, 1,3,4-thiadiazoles have been shown to possess antioxidant, antimicrobial, or anti-inflammatory biological activity. To take advantage of each of the inherent characteristics of the two aforementioned functional groups, 2-nicotinamido-1,3,4-thiadiazole, C8H6N4OS, was synthesized. Since d

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Jitianu, Andrei, Marc A. llies, Fabrizio Briganti, Andrea Scozzafava, and Claudiu T. Supuran. "Complexes With Biologically Active Ligands. Part 91 Metal Complexes of 5-Benzoylamino- and 5-(3-Nitrobenzoyl-Amino)-1,3,4-Thiadiazole-2-Sulfonamide as Carbonic Anhydrase Inhibitors." Metal-Based Drugs 4, no. 1 (1997): 1–7. http://dx.doi.org/10.1155/mbd.1997.1.

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Complexes containing the anions of 5-benzoylamido-1,3,4-thiadiazole-2-sulfonamide and 5-(3-nitro-benzoylamido)-1,3,4-thiadiazole-2-sulfonamid as ligands, and V(IV); Cr(III); Fe(III); Co(II); Ni(II); Cu(II) and Ag(I) were synthesized and characterized by standard procedures (elemental analysis; IR, electronic, and EPR spectroscopy; TG, magnetic and conductimetric measurements). The original sulfonamides and their metal complexes are strong inhibitors of two carbonic anhydrase (CA) isozymes, CA I and II.

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32

Xiong, Sang, Jian Lin Sun, and Yang Xu. "Adsorption Behavior of Thiadiazole as Corrosion Inhibitors on Copper Surface." Materials Science Forum 817 (April 2015): 204–11. http://dx.doi.org/10.4028/www.scientific.net/msf.817.204.

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Adsorption behavior of four typical thiadiazole derivatives as corrosion inhibitors on copper surface both in vacuum and aqueous media, including 1,3,4-thiadiazole-2,5-mercapto (T-SH), (1,3,4-thiadiazole-2,5-diyl) bis (sulfanol) (T-OH), S,S'-(1,3,4-thiadiazole-2,5-diyl) bis (O-hydrogen carbonothioate) (T-COOH) and O,O'-dimethyl S,S'-(1,3,4-thiadiazole-2,5-diyl) bis (carbonothioate) (T-COOCH3), has been theoretically studied using quantum chemistry calculations and molecular dynamics simulations method, and the corrosion inhibition mechanism has been analyzed. The present conclusions have been

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33

Pandey, Alok, R. Rajavel, Sandeep Chandraker, and Deepak Dash. "Synthesis of Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole and Its Analgesic, Anti-Inflammatory and Anti-Bacterial Activity." E-Journal of Chemistry 9, no. 4 (2012): 2524–31. http://dx.doi.org/10.1155/2012/145028.

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Schiff Bases of 2-amino-5-aryl-1,3,4-thiadiazole derivatives have been synthesized with different aromatic aldehyde. 1,3,4-thiadiazole derivatives were prepared by the reaction of thiosemicarbazide, sodium acetate and aromatic aldehyde. The structures of the titled Schiff bases were elucidated by IR and1H NMR spectral measurements. All the compounds were evaluated for their analgesic activity against swiss albino mice, anti-inflammatory activity against Wister albino rats. The compounds showed significant antibacterial activity againstStaphylococcus aureus(gram-positive) bacteria andE. coli(gr

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34

Keerthi Kumar, Chinnagiri T., Jathi Keshavayya, Tantry N. Rajesh, Sanehalli K. Peethambar, and Angadi R. Shoukat Ali. "Synthesis, Characterization, and Biological Activity of 5-Phenyl-1,3,4-thiadiazole-2-amine Incorporated Azo Dye Derivatives." Organic Chemistry International 2013 (August 18, 2013): 1–7. http://dx.doi.org/10.1155/2013/370626.

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5-Phenyl-1,3,4-thiadiazole-2-amine has been synthesized by single step reaction. A series of heterocyclic azodyes were synthesized by diazotisation of 5-phenyl-1,3,4-thiadiazole-2-amine by nitrosyl sulphuric acid followed by coupling with different coupling compounds such as 8-hydroxyquinoline, 2,6-diaminopyridine, 2-naphthol, N,N-dimethyl aniline, resorcinol, and 4,6-dihydroxypyrimidine. The dyes were characterized by UV-Vis, IR, 1H-NMR, 13C NMR, and elemental analysis. The synthesized compounds were also screened for biological activity.

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35

Kantlehner, Willi, Erwin Haug, Willy Kinzy, Oliver Scherr, and Ivo C. Ivanov. "Die Synthese von 2-Methyl-5-phenacyl-1,3,4-thiadiazolen / The Synthesis of 2-Methyl-5-phenacyl-1,3,4-thiadiazoles." Zeitschrift für Naturforschung B 59, no. 4 (2004): 366–74. http://dx.doi.org/10.1515/znb-2004-0403.

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Keywords2,5-Dimethyl-1,3,4-thiadiazole (1a) reacts which aromatic carboxylic acid esters 8a - u in the presence of excessive sodium hydride under condensation to give sodium enolates which afford on hydrolysis the phenacyl-1,3,4-thiadiazoles 9a - u. The action of aromatic carboxylic acid chlorides on 1a in the presence of triethylamine gives rise to the formation of mixtures of diacylated thiadiazole derivatives 16 and 18. In some cases the pure 3-acyl-phenacylidene-2,3-dihydro-1,3,4-thiadiazoles 16 can be isolated. Generally the compounds 16 are rearranged on heating in higher boiling solvent

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36

Lelyukh, M. I. "Biological activity of heterocyclic systems based on functionally substituted 1,3,4-thia(oxa)diazoles (a review)." Farmatsevtychnyi zhurnal, no. 6 (December 21, 2019): 43–53. http://dx.doi.org/10.32352/10.32352/0367-3057.6.19.05.

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1,3,4-Thiadiazole and oxadiazole hetetocycles are well-known pharmacophore scaffolds, which possess wide possibility for chemical modification and identified diverse pharmacological potential. Such essential and many-sided activities let to consider the mentioned heterocycles as ones of the crucial for expression of pharmacological activity, which confirm their importance for medicinal chemistry. Moreover, 1,3,4-oxadiazole cycle is a bioisostere for carboxylic, amide and ester groups, which mostly contribute to enhancement the pharmacological activity by participating in hydrogen bonding inter

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37

Tan, Ting Feng, Yan Xia Li, Li Gang Bai, Bian Peng Wu, Hua Yan Guo, and Zhi Cheng Suo. "A Facile Synthesis and Optical Properties of Novel 2-substituted-5-naphthylmethylene Thiadiazole Derivatives." Advanced Materials Research 1052 (October 2014): 188–92. http://dx.doi.org/10.4028/www.scientific.net/amr.1052.188.

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Three aryl and three naphthylmethylene derivatives containing thiadiazole ring have been synthesized. The structures of target compounds were characterized on the basis of spectral (FT-IR, 1H NMR, and MS). The optical properties were detected using UV-vis absorption spectroscopy and fluorescence spectroscopy. The absorption spectra of 1a, 2a and 3a substituted by naphthylmethylene are primarily characterized by a peak around 284 nm originating from naphthalene, which is different from that of compounds 1b, 2b and 3b. Compared to 1a and 2a (separated by a saturable atomic cluster −CH2−), the ma

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38

Shamanth, Sadashivamurthy, Kempegowda Mantelingu, Haruvegowda Kiran Kumar, Hemmige S. Yathirajan, Sabine Foro, and Christopher Glidewell. "Crystal structures of three 6-aryl-2-(4-chlorobenzyl)-5-[(1H-indol-3-yl)methyl]imidazo[2,1-b][1,3,4]thiadiazoles." Acta Crystallographica Section E Crystallographic Communications 76, no. 1 (2020): 18–24. http://dx.doi.org/10.1107/s2056989019016050.

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Three title compounds, namely, 2-(4-chlorobenzyl)-5-[(1H-indol-3-yl)methyl]-6-phenylimidazo[2,1-b][1,3,4]thiadiazole, C26H19ClN4S, (I), 2-(4-chlorobenzyl)-6-(4-fluorophenyl)-5-[(1H-indol-3-yl)methyl]imidazo[2,1-b][1,3,4]thiadiazole, C26H18ClFN4S, (II), and 6-(4-bromophenyl)-2-(4-chlorobenzyl)-5-[(1H-indol-3-yl)methyl]imidazo[2,1-b][1,3,4]thiadiazole, C26H18BrClN4S, (III), have been prepared using a reductive condensation of indole with the corresponding 6-aryl-2-(4-chlorobenzyl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehydes (aryl = phenyl, 4-fluorophenyl or 4-bromophenyl), and their crystal

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39

Pazalja, Mirha. "Electrochemical Oxidation of 2,5-Dimercapto-1,3,4-thiadiazole on Carbon Electrodes Modified with Ru(III) Schiff Base Complex." Kemija u industriji 70, no. 7-8 (2021): 401–10. http://dx.doi.org/10.15255/kui.2020.068.

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The thiol compound 2,5-dimercapto-1,3,4-thiadiazole is a potential cathode material. The redox reactions of the mentioned thiol compound are slow at room temperature but can be enhanced using electron transfer mediators. The electrochemical oxidation of 2,5-dimercapto-1,3,4-thiadiazole on the surface of carbon electrodes modified with Ruthenium(III) Schiff base complex was studied by voltammetric methods and amperometric flow injection analysis. The electrocatalytic properties of Ruthenium(III) Schiff base complex on glassy carbon and screen printed carbon electrodes are enhanced by the additi

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40

Sun, Na-Bo, Jian-Zhong Jin, and Wei Ke. "2,5-Bis[(3-chlorobenzyl)sulfanyl]-1,3,4-thiadiazole." Acta Crystallographica Section E Structure Reports Online 68, no. 6 (2012): o1620. http://dx.doi.org/10.1107/s1600536812019150.

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The complete molecule of the title compound, C16H12Cl2N2S3, is generated by crystallographic twofold symmetry, with the S atom of the thiadiazole ring lying on the rotation axis. The dihedral angle between the mean planes of the 1,3,4-thiadiazole and benzene rings is 87.19 (7)°. In the crystal, molecules are linked by C—H...N interactions and short S...S contacts [3.3389 (9) Å] occur.

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41

Hegab, Mohamed I., and Mohamed F. El Shehry. "Reactions of 2,2-Dialkyl-3-thioxochroman-4-one S-(1-Adamantylimides) with Some Nitrilimines." Zeitschrift für Naturforschung B 69, no. 4 (2014): 461–65. http://dx.doi.org/10.5560/znb.2014-3276.

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2a(E)-3-Thioxospiro[chroman-2,1ʹ-cyclohexane]-4-one S-(1-adamantylimide) (1) reacted with numerous nitrilimines (generated in situ via triethylamine dehydrohalogenation of the corresponding hydrazonoyl chlorides - i) in refluxing dry toluene to afford 3ʺ,5ʺ-disubstituted-300H,4ʹHdispiro[ cyclohexane-1,2ʹ-chromene-3ʹ,2ʺ-[1,3,4]thiadiazole]-4ʹ-ones 3a - i. Similarly, reaction of 2,2-dimethyl-3-thioxochroman-4-one S-(1-adamantylimide) (4) with nitrilimines in refluxing dry toluene afforded the corresponding 3ʹ,5ʹ-disubstituted-3,3-dimethyl-3ʹH,4H-spiro[chromene-3,2ʹ- [1,3,4]thiadiazole]-ones 5a -

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42

Tomma., Jumbad H., Mustafa S. Khazaal, and Rajaa K. Baker. "Synthesis, Characterization and Antibacterial Activity of New Chalcones Derived from New Aldehyde; 4-[5-(4`tolyl)-1,3,4-thiadiazole-2-yl] benzaldehyde." Ibn AL- Haitham Journal For Pure and Applied Science 30, no. 3 (2017): 68. http://dx.doi.org/10.30526/30.3.1603.

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New chalcones of -{ - - - y - - hi di z e- -y he y - - e e- - e- - - substituted phenyl have been prepared from condensation of a new of 4-[5-(4`-tolyl)1,3,4-thiadiazole-2-yl] benzaldehyde (which is synthesized by the reaction of 2- amino-5- (4`-tolyl) -1,3,4-thiadiazole and benzaldehyde) with 3- or 4- substituted acetophenones in alkaline medium. The physical, CHNS analysis and spectral data of the synthesized compounds were determined. The biological activity evaluated of new compounds showed that many of these compounds possess antibacterial activity.

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43

Zhivotova, T. S., R. E. Bakirova, S. D. Fazylov, S. K. Kabieva, and T. V. Kryazheva. "Synthesis and Biological Activity of 2,5-Bisubstituted Derivatives of 1,3,4-Thiadiazol-2,5-dithiol." Journal of Chemistry 2013 (2013): 1–4. http://dx.doi.org/10.1155/2013/635079.

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By reaction of 1,3,4-thiadiazol-2,5-dithiol with different organohalogens, chlorides of carboxylic acids, acrylic acid derivatives, alkaloids, and secondary amines, various derivatives of 2,5-bi-substituted 1,3,4-thiadiazole were synthesized, and biological properties of some of them were studied.

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44

EL-Mahdy, Ahmed F. M., Hassan A. H. EL-Sherief, Zeinab A. Hozien, and Shiao-Wei Kuo. "A Convenient One-Pot and Rapid Microwave-Assisted Synthesis of Biologically Active s-Triazolo[3,4-b][1,3,4]Thiadiazine and s-Triazolo[3,4-b][1,3,4]Thiadiazole Nanoarchitectonics." Journal of Nanoscience and Nanotechnology 20, no. 5 (2020): 2917–29. http://dx.doi.org/10.1166/jnn.2020.17452.

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A rapid and efficient one-pot protocol has been developed for the synthesis of s-triazolo[3,4-b][1,3,4]thiadiazine and s-triazolo[3,4-b][1,3,4]thiadiazole nanoarchitectonics through the reaction of s-triazoles with ketones and nitriles in acetic acid containing a catalytic amount of sulfuric acid under microwave irradiation in excellent yields. With this catalytic reaction, the cheap sulfuric acid as well as other acids were examined as catalysts and the highly toxic and irritating haloketones and halonitriles were avoided to form. The effects of microwave power, temperature, time, solvent and

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45

Drapak, І. V. "Synthesis, diuretic activity research and QSAR-analysis of N-(1,3,4-tiadiazol-2-il)substituted amides of alkanecarboxylic acids." Farmatsevtychnyi zhurnal, no. 2 (May 10, 2019): 55–65. http://dx.doi.org/10.32352/0367-3057.2.19.06.

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Diuretics are effective drugs that are widely used in medicine, but have unwanted side effects. The derivative of thiadiazole – acetozolamide is a known diuretic. Therefore, the search for diuretics in this series and the establishment of quantitative «structure–activity» (QSAR) dependencies is appropriate. The aim of the work was to synthesis N-(1,3,4-thiadiazol-2-yl)substituted alkanes of alkanecarboxylic acids, study their diuretic activity, and QSAR analysis. The objects of the study were N-(1,3,4-thiadiazol-2-yl)substituted alkanes of alkanecarboxylic acids, obtained by the in

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46

El Ashry, El Sayed H., El Sayed Ramadan, Mohammed R. Amer, Yeldez El Kilany, Mohamed E. I. Badawy, and Entsar I. Rabea. "Synthesis and Antioxidant Activity of Novel 5-amino-2-alkyl/glycosylthio-1,3,4- thiadiazoles: Regioselective Alkylation and Glycosylation of the 5-amino-1,3,4- thiadiazole-2-thiol Scaffold." Current Organic Synthesis 16, no. 5 (2019): 801–9. http://dx.doi.org/10.2174/1570179416666190415113847.

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Objective: 5-Amino-2-alkyl/glycosylthio-1,3,4-thiadiazoles have been synthesized by the reaction of 5-amino-1,3,4-thiadiazole-2-thiol with a variety of alkylating agents or glycosyl halides in the presence of anhydrous potassium carbonate in dry acetone. Methods: The structures of the newly synthesized compounds have been established based on their spectral data (FT-IR, 1H- and 13C-NMR) and mass spectrometry. They were tested for their antioxidant behaviour by the use of 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method. The in silico pharmacokinetics ADME properties of the p

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47

Wang, Pin-liang, Hai-ling Li, Si-shun Kang, and Hai-bo Wang. "2-{[3-(4-Chlorophenyl)-1,2,4-oxadiazol-5-yl]methylsulfanyl}-5-methyl-1,3,4-thiadiazole." Acta Crystallographica Section E Structure Reports Online 63, no. 11 (2007): o4411. http://dx.doi.org/10.1107/s160053680705177x.

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The title compound, C12H9ClN4OS2, was synthesized via condensation of 5-chloromethyl-3-(4-chlorophenyl)-1,2,4-oxadiazole with 5-mercapto-2-methyl-1,3,4-thiadiazole. The benzene and oxadiazole rings are coplanar due to the extended aromatic system. The angle between this plane and the thiadiazole ring is 82.2 (3)°.

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48

Shiri, Fereshteh, Somaye Shahraki, Sadegh Baneshi, Massoud Nejati-Yazdinejad, and Mostafa Heidari Majd. "Synthesis, characterization, in vitro cytotoxicity, in silico ADMET analysis and interaction studies of 5-dithiocarbamato-1,3,4-thiadiazole-2-thiol and its zinc(ii) complex with human serum albumin: combined spectroscopy and molecular docking investigations." RSC Advances 6, no. 108 (2016): 106516–26. http://dx.doi.org/10.1039/c6ra17322e.

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49

Amiel, Pascale, Abdallah Mahamoud, Pierre Brouant, et al. "Tautomérie du 2,5-dimercapto-1,3,4-thiadiazole et synthèse de thiadiazoloacridiniques." Canadian Journal of Chemistry 73, no. 8 (1995): 1258–66. http://dx.doi.org/10.1139/v95-154.

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Some 2(3H)-thione-5-alkylthio-1,3,4-thiadiazoles were prepared with a view to arylating these compounds with 9-chloroacridines. Using pyridine as solvent and base, this arylation led to the 2-thione-(N)3-acridinyl-5-alkylthio-1,3,4-thiadiazoles. Molecular structures of the latter were determined either by NMR spectroscopy or by referring to X-ray crystallography of the 5-(diethylaminoethylthio)-1,3,4-thiadiazole-2-thione. Thus, with respect to the tautomeric equilibrium of the compound investigated, the thione group was detected either in the solid state or in solution. In contrast, 2-acridiny

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50

Song, Ye, Yu-Fei Ji, Min-Yan Kang та Zhi-Liang Liu. "Bis(2-amino-5-methyl-1,3,4-thiadiazole-κN 3)dichloridocobalt(II)". Acta Crystallographica Section E Structure Reports Online 68, № 6 (2012): m772. http://dx.doi.org/10.1107/s1600536812020995.

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In the monomeric title complex, [CoCl2(C3H5N3S)2], the CoII atom is tetracoordinated by two chloride anions and two N atoms from two monodentate 2-amino-5-methyl-1,3,4-thiadiazole ligands, giving a slightly distorted tetrahedral stereochemistry [bond angle range about Co = 105.16 (12)–112.50 (10)°]. In the complex, the dihedral angle between the 1,3,4-thiadiazole planes in the two ligands is 72.8 (1)°. There are two intramolecular N—H...Cl interactions in the complex unit, while in the crystal, intermolecular N—H...N and N—H...Cl hydrogen bonds link these units into a two-dimensional layered s

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