Academic literature on the topic '1, 4-naphthoquinone'

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Journal articles on the topic "1, 4-naphthoquinone"

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Ma, Qinge, Rongrui Wei, and Zhipei Sang. "Structural Characterization and Hepatoprotective Activity of Naphthoquinone From Cucumis bisexualis." Natural Product Communications 15, no. 1 (2020): 1934578X2090289. http://dx.doi.org/10.1177/1934578x20902898.

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Three new naphthoquinones, namely 5,8-dihydroxy-7′-isopropyl-furan ring-1″-prenyl-naphthoquinone (1), 5,8-dihydroxy-7′-propenyl-furan ring-1″-isopropanol-naphthoquinone (2), and 5,8-dihydroxy-7′-isopropanol-furan ring-1″-(5″-hydroxyphenyl)-naphthoquinone (3), along with 10 known naphthoquinone derivatives (4-13) were isolated from Cucumis bisexualis for the first time. All the compounds were elucidated on the basis of spectroscopic data analysis and chemical evidence. Compounds (1-13) were evaluated for their hepatoprotective activites on human L-O2 cells. Among them, compounds 1, 4, and 8 exh
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Lynch, Daniel E., Ian McClenaghan, and Simon J. Coles. "2-Chloro-3-[4-(ethoxycarbonyl)-1-piperidyl]-1,4-naphthoquinone." Acta Crystallographica Section E Structure Reports Online 57, no. 2 (2001): o125—o126. http://dx.doi.org/10.1107/s1600536801000708.

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Gornostaev, Leonid M. "Synthesis of 5-hydroxy-10-R-benzo[a]phenazine-12-oxides by cyclization of 2-arylamino-1,4-naphthoquinone-1-oximes under the action of nitrating mixture." Butlerov Communications 61, no. 2 (2020): 12–23. http://dx.doi.org/10.37952/roi-jbc-01/20-61-2-12.

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The synthesis of рolycyclic quinoid compounds, which exhibit a wide range of biological activity is one of the most promising and actively developing areas of the fine organic synthesis. Heterocyclic compounds including those that can be donors of nitrogen oxide NO occupy a special place among biologically active structures. These substances include a number of N-oxides, e.g., 1,2-diazet-1,2-dioxides, furoxanes and their benzo analogs, and N,N′-pyrazole dioxides. The reason for the high biological activity of N-oxides of nitrogenous heterocycles, which cannot easily generate nitrogen oxide NO
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Coulidiati, Tangbadioa H., Bruna B. Dantas, Glaucia V. Faheina-Martins, Enéas Ricardo de Morais Gomes, Juan C. R. Gonçalves, and Demetrius A. Machado de Araújo. "Proapoptotic Effects of triazol-1,4-Naphthoquinones Involve Intracellular ROS Production and MAPK/ERK Pathway in Human Leukemia Cells." Anti-Cancer Agents in Medicinal Chemistry 20, no. 17 (2020): 2089–98. http://dx.doi.org/10.2174/1871520620666200721124221.

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Background : The natural products constitute an important source of antitumor and cytotoxic agents. Naphthoquinones are effectively quinones present in different plants, with demonstrated anticancer activities. A recent study conducted by our group demonstrated the antileukemic potential of two novel triazol-1,4- naphthoquinones derivatives, PTN (2-(4-Phenyl-1H-1,2,3-triazol-1-yl)-1,4-naphthoquinone) and MPTN (2-[4- (4-Methoxyphenyl)-1H-1,2,3-triazol-1-yl]-1,4-naphthoquinone). Although, the mechanisms underlying the proapoptotic effects of PTN and MPTN have not been fully elucidated so far. Ob
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WURM, G., and H. J. DUCHSTEIN. "ChemInform Abstract: 1,4-Naphthoquinones. Part 24. On the Dehalogenation of 2-/3-Halogen-1, 4-naphthoquinone Derivatives." ChemInform 26, no. 28 (2010): no. http://dx.doi.org/10.1002/chin.199528064.

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Lukeman, Matthew, Duane Veale, Peter Wan, V. Ranjit N. Munasinghe, and John ET Corrie. "Photogeneration of 1,5-naphthoquinone methides via excited-state (formal) intramolecular proton transfer (ESIPT) and photodehydration of 1-naphthol derivatives in aqueous solution." Canadian Journal of Chemistry 82, no. 2 (2004): 240–53. http://dx.doi.org/10.1139/v03-184.

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The photochemistry of naphthols 1, 2, 4, 5 and 9, and phenol 10 has been studied in aqueous solution with the primary aim of exploring the viability of such compounds for naphthoquinone and quinone methide photogeneration, along the lines already demonstrated by our group for phenol derivatives. 1-Naphthol (1) is known to be substantially more acidic than 2-naphthol (2) in the singlet excited state (pKa* = 0.4 and 2.8, respectively) and it was expected that this difference in excited-state acidity might be manifested in higher reactivity of 1-naphthol derivatives for photochemical reactions re
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Chaudhary, Ankita, and Jitender M. Khurana. "2-Hydroxy-1, 4-Naphthoquinone: A Versatile Synthon in Organic Synthesis." Current Organic Chemistry 20, no. 12 (2016): 1314–44. http://dx.doi.org/10.2174/1385272820666151125231522.

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Gupta, Deepti Bahl, and M. L. Gulrajani. "Kinetic and thermodynamic studies on 2-hydroxy-1, 4-naphthoquinone (lawsone)." Journal of the Society of Dyers and Colourists 110, no. 3 (2008): 112–15. http://dx.doi.org/10.1111/j.1478-4408.1994.tb01621.x.

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Jassbi, Amir R., Pahup Singh, Jyoti Lamba, Sonakshi Jain, Ian T. Baldwin, and Satoshi Tahara. "Transformation of Lapachol to a Novel Naphthoquinone and Related Compounds." Zeitschrift für Naturforschung B 61, no. 1 (2006): 73–77. http://dx.doi.org/10.1515/znb-2006-0115.

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In boiling pyridine, lapachol (1) is transformed into novel asymmetric naphthoquinone derivative, quadrilone (2), and into dehydro-α-lapachone (3), and adenophyllone (4). Lapachol used in the present study was isolated from the heartwood of Heterophragma quadriloculare and found to be the most abundant naphthoquinone.
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Цеплина, С. Н., та E. E. Цеплин. "Н-комплексы 1,2-нафтохинона с молекулами воды в водном растворе и их влияние на сдвиги полос поглощения". Оптика и спектроскопия 129, № 5 (2021): 599. http://dx.doi.org/10.21883/os.2021.05.50884.40-20.

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Optical absorption spectra of 1,2-naphthoquinone in non-polar (n-hexane) and polar (water) solvents were obtained. It is shown that the use of quantum chemical calculations based on time-dependent density functional theory (TDDFT B3LYP/6-311+G(d, p)) with the polarizable continuum model (PCM) for calculating 1,2-naphthoquinone in a solution of n-hexane and hydrogen complex of 1,2-naphthoquinone with two water molecules in an aqueous medium describes well the shifts of the absorption bands of 1,2-naphthoquinone in a water solution compared to a solution in n-hexane. Based on the analysis of dev
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Dissertations / Theses on the topic "1, 4-naphthoquinone"

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Shrestha, Jaya P. "Synthesis, Structure-Activity Relationship Study, and Mode of Action Study of 1,4-Naphthoquinone Based Anticancer and Antimicrobial Agents." DigitalCommons@USU, 2016. https://digitalcommons.usu.edu/etd/4925.

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Synthesizing bioactive small molecules by structural modification of 1,4-naphthoquinone was the primary goal of this research. Several bioactive compounds with anticancer, antifungal, and antibacterial activities were synthesized. All the synthetic protocols were optimized in such ways that do not require cumbersome purification. First, a new protocol for the synthesis of NQM111 was developed. NQM111 is a highly potent anticancer agent developed in our laboratory, but the old protocol does not provide enough quantity for in vivo study. Therefore, a new safe and improved method was developed wh
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Fisher, Kimberly D. "Thermal rearrangement of 4-aryl-4-hydroxy-2-cyclobuten-1-ones and application of the methodology in the formation of benzofuronaphthoquinones and benzocarbazolequinones." Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5872.

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Thesis (Ph. D.)--West Virginia University, 2008.<br>Title from document title page. Document formatted into pages; contains xvi, 200 p. : ill. Includes abstract. Includes bibliographical references (p. 95-97).
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Chang, Fu-Chaio, and 張富沼. "2,3-Disubstituted 5, 8-dimethoxy-1, 4-naphthoquinones." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/57648424408851238743.

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碩士<br>中國醫藥學院<br>藥物化學研究所<br>82<br>Some of 2,3-disubstituted 5,8-dimethoxy-1,4-naphthoquinones and its derivatives have been synthesized, and evaluated for antiinflammatory and antiallergic activities. Most of them showed significant effect on the inhibition of inflammation and allergy that caused by neutrophil and mast cell degranulation. An initial screening of these compounds, 2,3-dichloro-5,8-dimethoxy-1,4-naphtho quinone, 2-chloro-3-mthoxy-5,8-dimethoxy-1,4-naphthoquinone and 2-acetamido-3-chloro-5,8-dimethoxy-1,4-naphthoquinone were considered to be the most promising compound.
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Book chapters on the topic "1, 4-naphthoquinone"

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Akerboom, T. P. M., T. Bultmann, and H. Sies. "Biliary Taurocholate Excretion During the Metabolism of 2-Methyl-1, 4-Naphthoquinone (Menadione) in Perfused Rat Liver." In Proceedings in Life Sciences. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74247-7_30.

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Conference papers on the topic "1, 4-naphthoquinone"

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Suttie, W. J., A. Cheung, and M. G. Wood. "ENZYMOLOGY OF THE VITAMIN K-DEPENDENT CARBOXYLASE: CURRENT STATUS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643991.

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The vitamin K-dependent microsomal carboxylase converts glutamyl residues in precursor proteins to γ-carboxyglutamyl (Gla) residues in completed proteins. The enzyme activity is present in significant activities in most non-skeletal tissues but has been studied most extensively in rat and bovine liver. Early studies of the enzyme utilized bound precursors of vitamin K-dependent clotting factors as substrates for the enzyme and demonstrated that the enzyme requires the reduced form of vitamin K (vitamin KH2), O2, and CO2. Subsequent investigations have taken advantage of the observation that th
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