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Journal articles on the topic '1-Azaspirocycles'

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1

Robinson, Andrea, Zhen Wang, Nicolas Spiccia, Christopher Gartshore, Jayamini Illesinghe, and William Jackson. "A Concise Cross-Metathesis Route to Enantiopure 1-Azaspirocycles." Synthesis 45, no. 22 (2013): 3118–24. http://dx.doi.org/10.1055/s-0033-1338527.

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2

L. Funk, Raymond, and Joy Umstead Daggett. "Intermolecular Cycloaddition Reactions of Exocyclic Nitrones. Facile Synthesis of 1-Azaspirocycles." HETEROCYCLES 26, no. 8 (1987): 2175. http://dx.doi.org/10.3987/r-1987-08-2175.

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3

Wang, Zhen James, Nicolas Daniel Spiccia, Christopher James Gartshore, Jayamini Illesinghe, William Roy Jackson, and Andrea Jane Robinson. "ChemInform Abstract: A Concise Cross-Metathesis Route to Enantiopure 1-Azaspirocycles." ChemInform 45, no. 15 (2014): no. http://dx.doi.org/10.1002/chin.201415062.

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4

Dake, Gregory. "Recent approaches to the construction of 1-azaspiro[4.5]decanes and related 1-azaspirocycles." Tetrahedron 62, no. 15 (2006): 3467–92. http://dx.doi.org/10.1016/j.tet.2006.01.071.

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5

Ito, Toshimasa, Naoki Yamazaki, and Chihiro Kibayashi. "Synthesis of 1-Azaspirocycles via Lewis Acid-Mediated Spirocyclization of Cyclic N-Acyl-N,O-acetals." Synlett 2001, no. 10 (2001): 1506–10. http://dx.doi.org/10.1055/s-2001-17475.

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6

Ito, Toshimasa, Naoki Yamazaki, and Chihiro Kibayashi. "ChemInform Abstract: Synthesis of 1-Azaspirocycles via Lewis Acid Mediated Spirocyclization of Cyclic N-Acyl-N,O-acetals." ChemInform 33, no. 6 (2010): no. http://dx.doi.org/10.1002/chin.200206152.

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7

Xiao, Kai-Jiong, Jie-Min Luo, Xiao-Er Xia, Yu Wang, and Pei-Qiang Huang. "General One-Pot Reductivegem-Bis-Alkylation of Tertiary Lactams/Amides: Rapid Construction of 1-Azaspirocycles and Formal Total Synthesis of (±)-Cephalotaxine." Chemistry - A European Journal 19, no. 39 (2013): 13075–86. http://dx.doi.org/10.1002/chem.201302096.

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8

Yeh, Ming-Chang P., Cheng-Wei Fang, and Hsin-Hui Lin. "Facile Synthesis of Azaspirocycles via Iron Trichloride-Promoted Cyclization/Chlorination of Cyclic 8-Aryl-5-aza-5-tosyl-2-en-7-yn-1-ols." Organic Letters 14, no. 7 (2012): 1830–33. http://dx.doi.org/10.1021/ol300434m.

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9

Xiao, Kai-Jiong, Jie-Min Luo, Xiao-Er Xia, Yu Wang, and Pei-Qiang Huang. "ChemInform Abstract: General One-Pot Reductive gem-Bis-alkylation of Tertiary Lactams/Amides: Rapid Construction of 1-Azaspirocycles and Formal Total Synthesis of (.+-.)-Cephalotaxine." ChemInform 45, no. 9 (2014): no. http://dx.doi.org/10.1002/chin.201409106.

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10

Yeh, Ming-Chang P., Cheng-Wei Fang, and Hsin-Hui Lin. "ChemInform Abstract: Facile Synthesis of Azaspirocycles via Iron Trichloride Promoted Cyclization/Chlorination of Cyclic 8-Aryl-5-aza-5-tosyl-2-en-7-yn-1-ols." ChemInform 43, no. 31 (2012): no. http://dx.doi.org/10.1002/chin.201231095.

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11

Chiba, Shunsuke, and Atsushi Kaga. "Synthesis of Tricyclic Marine Alkaloids, Cylindricines, Lepadiformines, Fasicularin, and Polycitorols: A Recent Update." Synthesis 50, no. 04 (2017): 685–99. http://dx.doi.org/10.1055/s-0036-1589521.

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Cylindricines, lepadiformines, and fasicularin are tricyclic marine alkaloids bearing perhydropyrrolo- and pyrido[2,1-j] frameworks having divergent chemical functionalities. They have been isolated from marine tunicates over the last two decades and found to have a range of cytotoxicity such as DNA-alkylating ability. Recently, polycitorols have emerged as a new member of this alkaloid family. Their unique structural features and biological activities have intrigued many researchers and challenged them in their synthesis. This review describes recent syntheses of the tricyclic alkaloids based
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12

Kalaitzakis, Dimitris, Eirini Antonatou, and Georgios Vassilikogiannakis. "One-pot synthesis of 1-azaspiro frameworks initiated by photooxidation of simple furans." October 24, 2013. https://doi.org/10.1039/C3CC47690A.

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A range of 1-azaspirocycles, spiroaminals and 1,6-diazaspirocycles has been synthesized, starting from simple and readily accessible furan precursors, using a cascade reaction sequence initiated by singlet oxygen.
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13

Fleurisson, Claire, Nessrine Graidia, Jihed Azzouz, et al. "Design and Evaluation of Azaspirocycles as RNA binders." Chemistry – A European Journal, November 13, 2024. http://dx.doi.org/10.1002/chem.202403518.

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This study presents efficient synthetic pathways for preparing novel azaspirocycles. These methodologies involve functionalizing key bicyclic hydrazines with a substituent on one of their bridgehead carbon atoms. The desired spirocyclic cores were successfully obtained through double reductive amination reactions, intramolecular cyclizations, and cleavages of the N‐N bond. The isolated molecules possess unique three‐dimensional structures, suggesting potential applications in medicinal chemistry and drug discovery. With the growing interest in targeting nucleic acids as a complementary approac
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14

Dake, Gregory. "Recent Approaches to the Construction of 1-Azaspiro[4.5]decanes and Related 1-Azaspirocycles." ChemInform 37, no. 27 (2006). http://dx.doi.org/10.1002/chin.200627245.

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15

"[4+1]-Spiroannulation of Bromophenols with α,β-Unsaturated Imines: Synthesis of Azaspirocycles". Synfacts 16, № 12 (2020): 1404. http://dx.doi.org/10.1055/s-0040-1719477.

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16

FUNK, R. L., and J. UMSTEAD DAGGETT. "ChemInform Abstract: Intermolecular Cycloaddition Reactions of Exocyclic Nitrones. Facile Synthesis of 1-Azaspirocycles." ChemInform 19, no. 4 (1988). http://dx.doi.org/10.1002/chin.198804218.

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17

BRYCE, M. R., J. M. GARDINER, P. J. HORTON, and S. A. SMITH. "ChemInform Abstract: Synthesis and Reactions of 1-Azaspirocycles: 1-Azaspiro(4.5)decane and 1-Azaspiro(4.4)nonane Ring Systems." ChemInform 20, no. 27 (1989). http://dx.doi.org/10.1002/chin.198927161.

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