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Journal articles on the topic '11α- hydroxyprogesterone'

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Published: 3 June 2025
Last updated: 31 July 2025

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1

Lai, Tian Chao, Yun Dai, Bin Zhou, Guang Jian Shen, Hai Lin Su, and Gang Du. "Microbial Hydroxylation of Progesterone with Aspergillus ustus." Advanced Materials Research 807-809 (September 2013): 410–13. http://dx.doi.org/10.4028/www.scientific.net/amr.807-809.410.

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Progesterone was biotransformed byAspergillus ustusin this paper. Two products were obtained and they were identified as 11α-hydroxyprogesterone and 11α,15β-dihydroxyprogesterone by NMR and MS. The fermentation process of biotransformtion had been studied with HPLC and 11α-hydroxyprogesterone was the main product.
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2

Kozłowska, Ewa, Jordan Sycz, and Tomasz Janeczko. "Hydroxylation of Progesterone and Its Derivatives by the Entomopathogenic Strain Isaria farinosa KCh KW1.1." International Journal of Molecular Sciences 23, no. 13 (2022): 7015. http://dx.doi.org/10.3390/ijms23137015.

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Progesterone biotransformation is worth studying because of the high industrial value of its derivatives. This study investigated the catalytic ability of the entomopathogenic filamentous fungus strain Isaria farinosa KCh KW1.1 to transform progesterone derivatives: 11α-hydroxyprogesterone, 17α-hydroxyprogesterone, 16α,17α-epoxyprogesterone and pregnenolone. In the culture of Isaria farinosa KCh KW1.1, 11α-hydroxyprogesterone was effectively transformed into only one product: 6β,11α-dihydroxyprogesterone. Transformation of 17α-hydroxyprogesterone gave three hydroxy derivatives: 6β,17α-dihydrox
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3

Nickavar, Bahman, Hossein Vahidi та Mehrnoosh Eslami. "An efficient biotransformation of progesterone into 11α-hydroxyprogesterone by Rhizopus microsporus var. oligosporus". Zeitschrift für Naturforschung C 74, № 1-2 (2018): 9–15. http://dx.doi.org/10.1515/znc-2018-0092.

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Abstract Rhizopus microsporus var. oligosporus is a fungus that belongs to the Mucoraceae family that is used for the preparation of some soy-fermented foods. Microbial biotransformation of progesterone by R. microsporus var. oligosporus afforded some monohydroxylated and dihydroxylated metabolites. The main product was purified using chromatographic methods and identified as 11α-hydroxyprogesterone on the basis of its spectroscopic features. Time course studies by high-performance thin-layer chromatography demonstrated that this fungi efficiently hydroxylated progesterone at the 11α-position
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4

Choudhary, Muhammad Iqbal, Muhammad Nasir, Shamsun N. Khan та ін. "Microbial Hydroxylation of Hydroxyprogesterones and α-Glucosidase Inhibition Activity of Their Metabolites". Zeitschrift für Naturforschung B 62, № 4 (2007): 593–99. http://dx.doi.org/10.1515/znb-2007-0419.

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Microbial transformation of 11α-hydroxyprogesterone (1) with Cunninghamella elegans, Gibberella fujikuroi, Fusarium lini, and Candida albicans yielded 11α,15α,16α-trihydroxypregn-4- ene-3,20-dione (3), 11α-hydroxy-5α-pregnane-3,20-dione (4), 6β ,11α-dihydroxypregn-4-ene-3,20- dione (5), 11α-hydroxypregna-1,4-diene-3,20-dione (6), 11α,17β -dihydroxyandrost-4-en-3-one (7), and 11α,15α-dihydroxypregn-4-ene-3,20-dione (8). On the other hand, microbial transformation of 17α-hydroxyprogesterone (2) with Cunninghamella elegans and Fusarium lini yielded 11α,17α- dihydroxypregn-4-ene-3,20-dione (9), an
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5

Yoshida, Hirokazu, Shiro Nakai, Fusako Nimbari, Kiyoko Yoshimoto та Tadashi Nishimura. "Synthesis of 11α-hydroxyprogesterone hartens". Steroids 53, № 6 (1989): 727–38. http://dx.doi.org/10.1016/0039-128x(89)90063-9.

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6

Kasal, Alexander, та Světlana Pásztorová. "Synthesis of RIA Haptens: 3α,11α-Dihydroxy-5α-pregnan-20-one 11-Hemisuccinate". Collection of Czechoslovak Chemical Communications 58, № 3 (1993): 619–28. http://dx.doi.org/10.1135/cccc19930619.

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5α-Pregnane-3α,11α-diol-20-one (XVII) was prepared by hydroxylation of 5α-pregnan-3α-ol-20-one (XVI) by Rhizopus nigricans and by chemical conversion of 11α-hydroxyprogesterone (I). The diol XVII was partially acylated with 2-(trimethylsilyl)ethyl hydrogen succinate and the 11α-succinate XVIII was converted to the target 11α-hemisuccinate XXI.
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7

Du, Gang, Tian Chao Lai, Hai Ying Yang, Jing Xian Sun, Ming Hong Chen, and Guang Qiu Zhang. "Microbial Hydroxylation of Progesterone with Phomopsis Sp." Advanced Materials Research 781-784 (September 2013): 1168–71. http://dx.doi.org/10.4028/www.scientific.net/amr.781-784.1168.

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Microbial hydroxylation of progesterone occurred in the biotransformation by Phomopsis sp.. The conversion products were purified by column chromatography with ether/EtOAc and characterized by spectroscopic methods including 1HNMR, 13C NMR, IR, UV and MS. Those conversion products were identified as 11α-hydroxyprogesterone (2), 11α,15β-dihydroxy progesterone (3),11α-dihydroxypreg-1,4-dien-3,20-dione (4), 6β,15βdihydroxypregesterone (5) and 7β,15βdihydroxypregesterone (6).
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8

Yamaguchi, Tokutaro, Joo-Ho Lee, A. Rang Lim, Eun-Ji Yu та Tae-Jin Oh. "Biotransformation into 11α-hydroxyprogesterone glucosides by glucosyltransferase". Steroids 145 (травень 2019): 32–38. http://dx.doi.org/10.1016/j.steroids.2019.02.008.

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9

Yildirim, Kudret, Ilknur Kupcu, and Fatih Gulsan. "Biotransformation of Some Steroids by Aspergillus wentii." Zeitschrift für Naturforschung C 65, no. 11-12 (2010): 688–92. http://dx.doi.org/10.1515/znc-2010-11-1209.

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First steroid biotransformations performed by Aspergillus wentii MRC 200316 are reported. Testosterone (1) yields 6β-hydroxytestosterone (3) and 14α-hydroxytestosterone (4) while progesterone (2) yields 11α-hydroxyprogesterone (5).
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10

Al-Awadi, Sameera, Mohammed Afzal та Sosamma Oommen. "Studies onGeobacillus stearothermophilus– Part V: Transformation of 11α-hydroxyprogesterone". Biocatalysis and Biotransformation 23, № 5 (2005): 323–28. http://dx.doi.org/10.1080/10242420500285710.

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11

Qian, Miao, Yulong Zeng, Shuhong Mao та ін. "Engineering of a fungal steroid 11α-hydroxylase and construction of recombinant yeast for improved production of 11α-hydroxyprogesterone". Journal of Biotechnology 353 (липень 2022): 1–8. http://dx.doi.org/10.1016/j.jbiotec.2022.05.012.

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12

Gent, Rachelle, Desmaré Van Rooyen, Stephen L. Atkin, and Amanda C. Swart. "C11-hydroxy and C11-oxo C19 and C21 Steroids: Pre-Receptor Regulation and Interaction with Androgen and Progesterone Steroid Receptors." International Journal of Molecular Sciences 25, no. 1 (2023): 101. http://dx.doi.org/10.3390/ijms25010101.

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C11-oxy C19 and C11-oxy C21 steroids have been identified as novel steroids but their function remains unclear. This study aimed to investigate the pre-receptor regulation of C11-oxy steroids by 11β-hydroxysteroid dehydrogenase (11βHSD) interconversion and potential agonist and antagonist activity associated with the androgen (AR) and progesterone receptors (PRA and PRB). Steroid conversions were investigated in transiently transfected HEK293 cells expressing 11βHSD1 and 11βHSD2, while CV1 cells were utilised for agonist and antagonist assays. The conversion of C11-hydroxy steroids to C11-oxo
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13

Souness, Graham W., та David J. Morris. "11α- and 11β-Hydroxyprogesterone, Potent Inhibitors of 11β-Hydroxysteroid Dehydrogenase, Possess Hypertensinogenic Activity in the Rat". Hypertension 27, № 3 (1996): 421–25. http://dx.doi.org/10.1161/01.hyp.27.3.421.

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14

Kirk, David N., та Barry W. Miller. "Synthesis of conjugates of 11α-hydroxyprogesterone with β-nicotinamide adenine dinucleotide (β-NAD) and adenosine triphosphate (ATP)". J. Chem. Soc., Perkin Trans. 1, № 11 (1988): 2983–92. http://dx.doi.org/10.1039/p19880002983.

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15

Bacigalupo, Maria A., Stefano Colombi, Rossella Saita та Cornelia Parini. "Influence of functional groups on homologous antibody affinity of 11α-hydroxyprogesterone derivatives. I. Synthesis and affinity evaluation". Steroids 52, № 5-6 (1988): 571–81. http://dx.doi.org/10.1016/0039-128x(88)90124-9.

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16

Luconi, Michaela, Lorella Bonaccorsi, Mario Maggi, et al. "Identification and Characterization of Functional Nongenomic Progesterone Receptors on Human Sperm Membrane1." Journal of Clinical Endocrinology & Metabolism 83, no. 3 (1998): 877–85. http://dx.doi.org/10.1210/jcem.83.3.4672.

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The presence of functional nongenomic progesterone (P) receptors in human spermatozoa has been investigated by equilibrium binding studies in intact spermatozoa, ligand blot and Western blot analysis of sperm lysates, as well as determination of the effects of the steroid on sperm intracellular Ca2+ concentrations. Binding experiments were performed using progesterone-11α-glucuronide-[125I]iodotyramine as tracer. Computer analysis of competition curves using different steroids as competitors indicated the presence of two distinct binding sites for P. The high affinity site (Kd in the nanomolar
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17

Gent, Rachelle, Therina du Toit та Amanda C. Swart. "11α-Hydroxyprogesterone, a potent 11β-hydroxysteroid dehydrogenase inhibitor, is metabolised by steroid-5α-reductase and cytochrome P450 17α-hydroxylase/17,20-lyase to produce C11α-derivatives of 21-deoxycortisol and 11-hydroxyandrostenedione in vitro". Journal of Steroid Biochemistry and Molecular Biology 191 (липень 2019): 105369. http://dx.doi.org/10.1016/j.jsbmb.2019.04.018.

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18

Predescu, Nicoleta Florentina, Silvia Iga, Alina Nicolescu, and Dumitru Petru Iga. "Koenigs-Knorr Synthesis of Galactofuranosides of Estrone, Androstanolone, 11a-Hydroxyprogesterone and Prednisolone." Revista de Chimie 59, no. 1 (2008): 52–55. http://dx.doi.org/10.37358/rc.08.1.1706.

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Galactofuranosylation has been accomplished with 1-bromo-1-deoxy-2,3,5,6-tetra-O-benzoyl-a-D-galactofuranoside in the presence of cadmium carbonate as promotor. Glycosylation agent has been prepared by bromination of penta-O-benzoyl-ab-D-galactofuranoside with a solution of hydrogen bromide in glacial acetic acid. The precursor of the latter reaction has been produced by benzoylation of D-galactose that had been heated in pyridine while still warm. The following hydroxysteroids have been selected as being representative in terms of configuration, type of hybridization of carbon bearing hydroxy
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19

Hemauer, Sarah, Ru Yan, Svetlana Patrikeeva, et al. "113: Metabolism of 17-hydroxyprogesterone caproate by the dually perfused human placental lobule." American Journal of Obstetrics and Gynecology 197, no. 6 (2007): S45. http://dx.doi.org/10.1016/j.ajog.2007.10.124.

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20

Eckstein, B., I. Khan та G. Gibori. "Difference in luteal and placental P45017α: substrate preference and hormonal regulation in the rat". Journal of Endocrinology 115, № 3 (1987): 387–93. http://dx.doi.org/10.1677/joe.0.1150387.

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ABSTRACT The purpose of this study was to assess the substrate specificity of P45017α in both the corpus luteum and placenta of pregnant rats, and to analyse the site at which LH/human chorionic gonadotrophin (hCG) regulates the activities of this enzyme. To distinguish the substrate preference, placentas and corpora lutea were obtained from rats on day 15 of pregnancy. Tissues were homogenized and the 10 000 g supernatants incubated in the presence of equimolar concentrations of [14C]progesterone and [3H]17α-hydroxyprogesterone as substrate with either NADH or NADPH as cofactors for 2, 8, 16
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21

Bryan, Sinead M., John W. Honour, and Peter C. Hindmarsh. "Management of Altered Hydrocortisone Pharmacokinetics in a Boy with Congenital Adrenal Hyperplasia Using a Continuous Subcutaneous Hydrocortisone Infusion." Journal of Clinical Endocrinology & Metabolism 94, no. 9 (2009): 3477–80. http://dx.doi.org/10.1210/jc.2009-0630.

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Background: Conventional hydrocortisone dosing schedules do not mimic the normal circadian rhythm of cortisol, making it difficult to optimize treatment in congenital adrenal hyperplasia (CAH). Case Details: We report a 14.5-year-old boy with CAH who had reduced bioavailability [42% (normal 80% orally and 100% by im route)] and increased clearance [half-life 50 min (normal range, 70–100 min)] of oral doses of hydrocortisone leading to ambient serum 17-hydroxyprogesterone concentrations of 400 nmol/liter (14.5 ng/ml) and androstenedione concentrations of 24.9 nmol/liter (7.1 ng/ml). Interventio
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22

Castracane, V. Daniel, та Terry Gimpel. "Comparison of three methods for 17α-Hydroxyprogesterone". Journal of Clinical Laboratory Analysis 11, № 4 (1997): 179–85. http://dx.doi.org/10.1002/(sici)1098-2825(1997)11:4<179::aid-jcla1>3.0.co;2-4.

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23

Badwe, Rajendra, Shalaka Joshi, Rohini Hawaldar, et al. "Abstract PO3-12-11: A phase-3 randomized controlled study to evaluate the role of hydroxyprogesterone in prevention of chemotherapy induced neurotoxicity in women with breast cancer." Cancer Research 84, no. 9_Supplement (2024): PO3–12–11—PO3–12–11. http://dx.doi.org/10.1158/1538-7445.sabcs23-po3-12-11.

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Abstract Introduction Chemotherapy induced peripheral neuropathy (CIPN) is seen in 60% breast cancer patients who receive paclitaxel-based chemotherapy with no conclusively known pathophysiology. Hydroxyprogesterone is known to have neuroprotective and neuro-regenerative potential. We conducted a randomized controlled trial assessing the role of hydroxyprogesterone in reducing the incidence and severity of CIPN. Methodology Histologically proven, post-menopausal, non-metastatic breast cancer patients without pre-existing neuropathy, planned to receive paclitaxel (with or without trastuzumab) i
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24

Wood, S. Lindsay, Bria N. Williams, Jeff M. Szychowski та John Owen. "The Effect of Intramuscular 17α-Hydroxyprogesterone in Women Screened for Shortened Cervical Length". American Journal of Perinatology 37, № 07 (2019): 659–65. http://dx.doi.org/10.1055/s-0039-3400448.

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Abstract Objective This article assesses the effect of weekly intramuscular 17α-hydroxyprogesterone caproate (17P) on midtrimester cervical length (CL) in patients with prior spontaneous preterm birth. Study Design Retrospective cohort study of all singletons that underwent CL screening at a single institution from 2011 to 2016. The timing of 17P exposure was assessed. The primary outcome was shortest midtrimester CL. Secondary outcomes included gestational age at delivery, rate of short cervix, cerclage, preterm labor admission, and preterm premature rupture of the membranes (PROM). Multivari
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25

Gidlöf, Sebastian, Anna Wedell, and Anna Nordenström. "Gestational Age Correlates to Genotype in Girls with CYP21 Deficiency." Journal of Clinical Endocrinology & Metabolism 92, no. 1 (2007): 246–49. http://dx.doi.org/10.1210/jc.2006-1369.

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Abstract Context: The mechanisms behind onset of labor and prolongation of pregnancy are not fully understood, but steroid hormones are thought to contribute. 17-Hydroxyprogesterone has been shown to prolong pregnancy in humans. Male fetuses have been reported to have longer gestation than females. Objective: The objective of the study was to investigate whether severity of 21-hydroxylase gene (CYP21) deficiency in fetuses with congenital adrenal hyperplasia (CAH) correlates with length of pregnancy. Design and Subjects: The gestational age (GA) of a cohort of CAH patients born between 1978 an
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26

Makela, S. K., and G. Ellis. "Nonspecificity of a direct 17 alpha-hydroxyprogesterone radioimmunoassay kit when used with samples from neonates." Clinical Chemistry 34, no. 10 (1988): 2070–75. http://dx.doi.org/10.1093/clinchem/34.10.2070.

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Abstract We analyzed 240 samples for 17 alpha-hydroxyprogesterone (17-OHP) with the direct-assay kit ("Coat-A-Count" method for serum samples) from Diagnostic Products Corp. (DPC). The specimens were from 50 patients with known or suspected congenital adrenal hyperplasia (CAH); 74 mostly hospitalized neonates and infants, ages three days to three months; and 116 other patients, ages six months to 23 years. Samples from the CAH group were also analyzed with our in-house assay. For 39 of the neonatal samples, the analysis with the DPC assay was repeated with re-solubilized material that had been
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27

Manuck, Tracy A., Kim Boggess, George Saade, et al. "113: Exposure to 17-alpha hydroxyprogesterone caproate (17P) influences expression of maternal serum proteins in progesterone signaling pathways." American Journal of Obstetrics and Gynecology 216, no. 1 (2017): S79—S80. http://dx.doi.org/10.1016/j.ajog.2016.11.1003.

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28

Sudeshna, Tripathy, Kumarasamy Anand, and Rudraiah Medhamurthy. "Analysis of 20alpha-hydroxysteroid dehydrogenase expression in the corpus luteum of the buffalo cow: effect of prostaglandin F2-alpha treatment on circulating 20alpha-hydroxyprogesterone levels." Reproductive Biology and Endocrinology 11, no. 1 (2013): 111. http://dx.doi.org/10.1186/1477-7827-11-111.

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29

Van der Willigen, AH, Peereboom-Wynia JD, T. Van Joost, and E. Stolz. "A preliminary study of the effect of 11a-hydroxyprogesterone on the hair growth in men suffering from androgenetic alopecia." Acta Dermato-Venereologica 67, no. 1 (1987): 82–85. http://dx.doi.org/10.2340/00015555678285.

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Ten male patients suffering from androgenetic alopecia were treated during one year with a lotion containing 1% 11a-hydroxyprogesterone. Eight untreated patients served as control group. The parameters used were hair root status, hair shaft diameter of anagen hair roots and number of hairs with a diameter less than 40 micron. After therapy the cranial region showed an increase in the number and mean hair shaft diameter of anagen hair roots and in the number of hair roots with a diameter less than 40 micron. The number of hair roots in catagen/telogen decreased, the number of dysplastic/dystrop
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30

Goncharov, N. P., and G. V. Katsiya. "The hormonal function of human gonads and adrenals at various age." Problems of Endocrinology 41, no. 2 (1995): 19–22. http://dx.doi.org/10.14341/probl11366.

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Results of radioimmunoassay of the adrenal and sex hormones and their precursors in the peripheral blood of men of different age groups are presented. The measurements were carried out in men of mature age of the two periods (22 to 35 years of age. I period, and 36 to 60. II period), elderly subjects aged 61 to 74, senile ones aged 75 to 90, and in long-livers aged 91 to 112. The content of the principal adaptive hormone, hydrocortisone, and its immediate precursor 11-deoxyhydrocortisone was found to be virtually the same in all age groups. At the same time, the levels of other precursors – pr
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31

Baronio, Federico, Alice Marzatico, Rosaria De Iasio, et al. "Premature Pubarche: Time to Revise the Diagnostic Approach?" Journal of Clinical Medicine 12, no. 6 (2023): 2187. http://dx.doi.org/10.3390/jcm12062187.

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Premature pubarche (PP) could represent the first manifestation of non-classic congenital adrenal hyperplasia caused by 21 hydroxylase deficiency (NC21OHD) (10–30% of cases). In the last 20 years, the necessity of performing an ACTH test to diagnose NC21OHD in all cases with PP has been questioned, with conflicting results. This study aims to retrospectively evaluate the predictive value of the basal androgens, 17-OHP levels, and auxological features in suggesting the presence of NC21OHD and, thus, the need for a standard ACTH test to confirm the diagnosis. In all, 111 consecutive patients (87
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32

Gonzalez Quintero, Victor Hugo, Lesley de la Torre, Niki Istwan, et al. "112: The impact of prior gestational age at preterm delivery on the effectiveness of 17 alpha-hydroxyprogesterone caproate (17OHPC) in clinical practice." American Journal of Obstetrics and Gynecology 201, no. 6 (2009): S57. http://dx.doi.org/10.1016/j.ajog.2009.10.127.

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33

Duffy, F. A., and A. M. Wallace. "How large a hormone can be measured by microencapsulated antibody?" Journal of Endocrinology 115, no. 1 (1987): 47–51. http://dx.doi.org/10.1677/joe.0.1150047.

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ABSTRACT The size of molecules able to be measured in immunoassays where antibody is encapsulated within semipermeable microcapsules is restricted by the pore size of the membrane. This study was performed to determine the approximate molecular weight cut-off of this membrane. Permeability was assessed by measuring which labelled hormones were able to enter and bind their respective microencapsulated antibody. Hormones with molecular weights of less than 4000 (angiotensin II, thyroxine, 17-hydroxyprogesterone, progesterone, testosterone and androstenedione) passed freely through the pores but
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34

Adams, E. F., N. G. Coldham та V. H. T. James. "Steroidal regulation of oestradiol-17β dehydrogenase activity of the human breast cancer cell line MCF-7". Journal of Endocrinology 118, № 1 (1988): 149–54. http://dx.doi.org/10.1677/joe.0.1180149.

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ABSTRACT We have examined the direct effects of progestins, oestrogens, peptide hormones and growth factors on oestradiol-17β dehydrogenase (OE2DH) activity of cultures of the human breast cancer cell line MCF-7. Cells were cultured in the presence of steroid or peptide for 6 days, after which the number of cells was determined and cellular OE2DH activity assessed. Progesterone, 6α-methyl-17α-hydroxyprogesterone acetate, norethisterone and d(−)-norgestrel all profoundly inhibited cell mitosis and stimulated reductive (oestrone→oestradiol-17β) and oxidative (oestradiol-17β→oestrone) OE2DH activ
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35

Schoonen, W. G. E. J., J. G. D. Lambert, J. W. Resink, W. J. A. R. Viveen, and P. G. W. J. Van Oordt. "A quantitative study of steroid bioconversions in the testis of the African catfish, Clarias gariepinus (Burchell), under natural spawning and natural and cultivated non-spawning conditions." Journal of Endocrinology 112, no. 2 (1987): 323–32. http://dx.doi.org/10.1677/joe.0.1120323.

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ABSTRACT Quantitative aspects of bioconversions in the testes of the African catfish (Clarias gariepinus) were studied in vitro by incubation of tissue with [3H]pregnenolone or [3H]androstenedione. During the breeding period, spawning and non-spawning animals were collected from their natural habitat, the Hula nature reserve, in northern Israel. In the same period, non-spawning animals were collected from a fish pond in the same region. It was shown that spawning was accompanied by significant changes in steroid bioconversions, i.e. a reduction in androgen synthesis, especially of 11β-hydroxya
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36

Kim, Jae Hyun, Young Ah Lee, Youn-Hee Lim, et al. "Changes in Adrenal Androgens and Steroidogenic Enzyme Activities From Ages 2, 4, to 6 Years: A Prospective Cohort Study." Journal of Clinical Endocrinology & Metabolism 105, no. 10 (2020): 3265–72. http://dx.doi.org/10.1210/clinem/dgaa498.

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Abstract Context The levels of adrenal androgens are increased through the action of steroidogenic enzymes with morphological changes in the adrenal zona reticularis. Objective We investigated longitudinal changes in androgen levels and steroidogenic enzyme activities during early childhood. Design and Participants From a prospective children’s cohort, the Environment and Development of Children cohort, 114 boys and 86 girls with available blood samples from ages 2, 4, and 6 years were included. Outcome Measurements Serum concentrations of adrenal androgens using liquid chromatography-tandem m
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37

Lan, Lê Thị Ngọc, та Trần Thị Chi Mai. "Đánh giá kỹ thuật định lượng 17-hydroxyprogesterone huyết thanh bằng phương pháp miễn dịch hóa phát quang trên máy Maglumi 800". Tạp chí Nghiên cứu Y học 169, № 8 (2023): 18–26. http://dx.doi.org/10.52852/tcncyh.v169i8.1812.

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Nghiên cứu này được thực hiện để xác nhận phương pháp định lượng 17-hydroxyprogesterone (17-OHP) huyết thanh bằng phương pháp miễn dịch hóa phát quang trên máy Maglumi 800. Khoảng tuyến tính được xác nhận theo hướng dẫn EP6 của CLSI. Độ chụm được xác nhận theo hướng dẫn EP5 của CLSI. Độ chính xác của phương pháp được xác nhận theo hướng dẫn EP7 và EP9 của CLSI. Kết quả xác nhận cho thấy phương pháp tuyến tính đến 59,1 nmol/L. Độ chụm ngắn hạn dao động từ 2,8 đến 6,3%, nhỏ hơn độ chụm cho phép dựa trên biến thiên sinh học ở mức tối ưu và độ chụm dài hạn giao động từ 3,4 đến 9,2% nhỏ hơn độ chụm
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38

Ghizzoni, Lucia, Marco Cappa, Alessandra Vottero, et al. "Relationship of CYP21A2 genotype and serum 17-hydroxyprogesterone and cortisol levels in a large cohort of Italian children with premature pubarche." European Journal of Endocrinology 165, no. 2 (2011): 307–14. http://dx.doi.org/10.1530/eje-11-0119.

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ObjectivePremature pubarche (PP) is the most frequent sign of nonclassic congenital adrenal hyperplasia (NCCAH) due to 21-hydroxylase deficiency in childhood. The aim of this study was to assess the relationship between the CYP21A2 genotype and baseline and ACTH-stimulated 17-hydroxyprogesterone (17-OHP) and cortisol serum levels in patients presenting with PP.Patients and methodsA total of 152 Italian children with PP were studied. Baseline and ACTH-stimulated 17-OHP and cortisol serum levels were measured and CYP21A2 gene was genotyped in all subjects.ResultsBaseline and ACTH-stimulated seru
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Naidansuren, Purevjargal, Cha-Won Park, Sang-Hwan Kim та ін. "Molecular characterization of bovine placental and ovarian 20α-hydroxysteroid dehydrogenase". REPRODUCTION 142, № 5 (2011): 723–31. http://dx.doi.org/10.1530/rep-11-0093.

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The enzyme 20α-hydroxysteroid dehydrogenase (20α-HSD) catalyzes the conversion of progesterone to its inactive form, 20α-hydroxyprogesterone. This enzyme plays a critical role in the regulation of luteal function in female mammals. In this study, we conducted the characterization and functional analyses of bovine 20α-HSD from placental and ovarian tissues. The nucleotide sequence of bovine 20α-HSD showed significant homology to that of goats (96%), humans (84%), rabbits (83%), and mice (81%). The mRNA levels increased gradually throughout the estrous cycle, the highest being in the corpus lute
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Lazar, Liora, Rivka Kauli, Celia Bruchis, Jardena Nordenberg, Avinoam Galatzer, and Athalia Pertzelan. "High prevalence of abnormal adrenal response in girls with central precocious puberty at early pubertal stages." European Journal of Endocrinology 133, no. 4 (1995): 407–11. http://dx.doi.org/10.1530/eje.0.1330407.

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Lazar L, Kauli R, Bruchis C, Nordenberg J. Galatzer A, Pertzelan A. High prevalence of abnormal adrenal response in girls with central precocious puberty at early pubertal stages. Eur J Endocrinol 1995;133:407–11. ISSN 0804–4643 Abnormal adrenal response is often observed in girls with precocious adrenarche (1). We studied the adrenal response in 112 girls with idiopathic true central precocious puberty (CPP) at early stages of puberty compared to that in 21 girls with normal puberty (controls). The aims of this study were to determine the prevalence of abnormal adrenal response at early stage
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Robertson, W. R., B. Davison, D. C. Anderson, J. Frost, and A. Lambert. "Effect of adrenocorticotrophin on cortisol and androstenedione secretion from dispersed cells of guinea-pig adrenal zonae fasciculata and reticularis." Journal of Endocrinology 109, no. 3 (1986): 399–404. http://dx.doi.org/10.1677/joe.0.1090399.

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ABSTRACT We have studied cortisol and androstenedione secretion by dispersed cells of the outer zona fasciculata (ZF) plus zona glomerulosa, and the inner zona reticularis (ZR) plus medulla of the guinea-pig adrenal. The ZF and ZR were microdissected apart, the cells dispersed and incubated (200 000 cells/ml) for 90 min in the presence of adrenocorticotrophin (ACTH; 500 ng/l), dibutyryl cyclic AMP (dbcAMP; 1 mmol/l), pregnenolone, 17-hydroxypregnenolone, 17-hydroxyprogesterone, 11-deoxycortisol and 21-deoxycortisol. The steroid concentrations were 5–25 μmol/l. Cortisol secretion was assayed by
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42

Sukhoverska, Mariia, Vasily Beniuk, Tatiana Kovaliuk, and Viktor Oleshko. "Modern view on the etiology and pathogenesis of hyperandrogenic conditions in women of reproductive age against the background of normal levels of male steroid hormones." Ukrainian Scientific Medical Youth Journal 146, no. 2 (2024): 109–18. http://dx.doi.org/10.32345/usmyj.2(146).2024.109-118.

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the article presents current literature data on the etiology and pathogenesis of hyperandrogenic conditions in women of reproductive age against the background of normal levels of male sex hormones. Most often, hyperandrogenic conditions occur due to excessive production of androgens by the ovaries or adrenal glands with increased sensitivity of sebaceous and hair follicle receptors to androgens. One of the main tools for clinical confirmation of hyperandrogenic conditions is the Ferriman-Gallway scale. Activation of androgen receptors, which are localized in the basal and glandular cells of t
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Wallace, A. M., J. Beesley, M. Thomson, C. A. Giles, A. M. Ross, and N. F. Taylor. "Adrenal status during the first month of life in mature and premature human infants." Journal of Endocrinology 112, no. 3 (1987): 473–80. http://dx.doi.org/10.1677/joe.0.1120473.

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ABSTRACT Measurements of (a) 17-hydroxyprogesterone (17-OHP) in blood collected onto filter paper after heel puncture by lancet and (b) steroid metabolites in random collections of urine, were made in human infants born from 25 weeks of gestation onwards. The concentration of 17-OHP in blood eluted from filter paper samples was inversely related to both gestational age and birth weight. In mature infants, 17-OHP concentrations fell rapidly soon after birth, whereas concentrations remained high over the first month of life in infants born earlier than 33 weeks of gestation. Sulphated urinary st
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Engels, M., K. Gehrmann, H. Falhammar, et al. "Gonadal function in adult male patients with congenital adrenal hyperplasia." European Journal of Endocrinology 178, no. 3 (2018): 285–94. http://dx.doi.org/10.1530/eje-17-0862.

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Context Current knowledge on gonadal function in congenital adrenal hyperplasia (CAH) is mostly limited to single-center/country studies enrolling small patient numbers. Overall data indicate that gonadal function can be compromised in men with CAH. Objective To determine gonadal function in men with CAH within the European ‘dsd-LIFE’ cohort. Design Cross-sectional clinical outcome study, including retrospective data from medical records. Methods Fourteen academic hospitals included 121 men with CAH aged 16–68 years. Main outcome measures were serum hormone concentrations, semen parameters and
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Peng, Shi-Hua, Jordi Segura, Magí Farré, and Xavier de la Torre. "Oral Testosterone Administration Detected by Testosterone Glucuronidation Measured in Blood Spots Dried on Filter Paper." Clinical Chemistry 46, no. 4 (2000): 515–22. http://dx.doi.org/10.1093/clinchem/46.4.515.

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Abstract Background: Blood sampling is not a common practice for sports drug testing. Our aim was to investigate whether dried blood spots on filter paper could be an alternative to plasma samples for monitoring steroid profiles in dope testing. Methods: We collected dried blood spots and plasma from six healthy Caucasian subjects after an oral 120-mg dose of testosterone undecanoate (TU). Nonconjugated testosterone, testosterone glucuronide (TG), androsterone glucuronide (AG), and etiocholanolone glucuronide (EtG) were measured by gas chromatography–mass spectrometry in both matrices. 17α-Hyd
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Garcia-Rudaz, Cecilia, Mauricio Dorfman, Srinivasa Nagalla та ін. "Excessive ovarian production of nerve growth factor elicits granulosa cell apoptosis by setting in motion a tumor necrosis factor α/stathmin-mediated death signaling pathway". REPRODUCTION 142, № 2 (2011): 319–31. http://dx.doi.org/10.1530/rep-11-0134.

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Excessive nerve growth factor (NGF) production by the ovary, achieved via a transgenic approach, results in arrested antral follicle growth, reduced ovulatory capacity, and a predisposition to cyst formation in response to mildly elevated LH levels. Two salient features in these mutant mice (termed 17NF) are an elevated production of 17α-hydroxyprogesterone (17-OHP4), testosterone, and estradiol (E2) in response to gonadotropins, and an increased frequency of granulosa cell (GC) apoptosis. In this study, we show that the increase in steroidal response is associated with enhanced expression ofC
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Nandagopal, Radha, Ninet Sinaii, Nilo A. Avila, et al. "Phenotypic profiling of parents with cryptic nonclassic congenital adrenal hyperplasia: findings in 145 unrelated families." European Journal of Endocrinology 164, no. 6 (2011): 977–84. http://dx.doi.org/10.1530/eje-11-0019.

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ObjectiveTo comprehensively phenotype parents identified with nonclassic congenital adrenal hyperplasia (NCCAH) by family genetic studies, termed here as cryptic NCCAH and to define the incidence of cryptic NCCAH in the parents of a large cohort of patients with 21-hydroxylase deficiency.DesignGenotyping was performed on 249 parents of 145 unrelated congenital adrenal hyperplasia (CAH) patients. Parents with two CYP21A2 mutations underwent extensive evaluation.ResultsOf the 249 parents, ten (4%; seven females and three males) were identified as having cryptic NCCAH. The majority was of ethnici
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Tolpygina, Margarita G., Marina A. Tarasova, Natalia V. Borovik, Elena V. Misharina, and Alyona V. Tiselko. "Effect of diabetes compensation on ovarian function recovery in women of reproductive age with type 1 diabetes mellitus." Journal of obstetrics and women's diseases 67, no. 5 (2018): 42–49. http://dx.doi.org/10.17816/jowd67542-49.

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Hypothesis/aims of study. The adverse effects of type 1 diabetes mellitus on the female reproductive system have been proved by many studies. There is still conflicting literature on the impact of diabetes and other factor compensation on ovarian function in women with type 1 diabetes mellitus.&#x0D; Study design, materials and methods. The current analysis was undertaken to study the effects of diabetes compensation on ovarian function in women with type 1 diabetes mellitus. In order to this, 180 individuals aged 20 to 40 years were examined. The main group consisted of 112 diabetic patients
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Yarney, T. A., J. Z. Kendall, and G. C. B. Randall. "Cytosolic glucocorticoid receptors in the porcine lung during development and after hypophysectomy or thyroidectomy." Journal of Endocrinology 127, no. 2 (1990): 341–49. http://dx.doi.org/10.1677/joe.0.1270341.

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ABSTRACT The ontogeny of fetal lung glucocorticoid receptors and their regulation by the fetal pituitary, adrenal and thyroid gland during lung maturation were investigated. Sites with a specificity typical of glucocorticoid receptors were detectable in lung cytosol, with the order of potency of steroids being dexamethasone &gt; cortisol &gt; corticosterone &gt; 11- -deoxycorticosterone &gt; progesterone &gt; 17α-hydroxyprogesterone &gt; oestradiol -17β ≃ testosterone ≃ androstenedione ≃ oestrone. The binding affinity for [3H]dexamethasone was high (Kd = 0·23–0·60 nmol/l) and showed an age-rel
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Votava, Felix, Dóra Török, József Kovács, et al. "Estimation of the false-negative rate in newborn screening for congenital adrenal hyperplasia." European Journal of Endocrinology 152, no. 6 (2005): 869–74. http://dx.doi.org/10.1530/eje.1.01929.

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Objective: Newborn screening based on measurement of 17α-hydroxyprogesterone (17-OHP) in a dried blood spot on filter paper is an effective tool for early diagnosis of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. Its most important rationale is prevention of a life-threatening salt-wasting (SW) crisis; in moderate forms of CAH, early diagnosis and treatment may prevent permanent negative effects of androgen overproduction. Our target was to analyse if all CAH patients who had been identified clinically before puberty would have been detected by the newborn screening.
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