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Journal articles on the topic '11 and 6 babies showed complete resolution'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Dr., Shazad Najeeb Dr. Arshad Sohail DR. Muhammad Ali Raza Dr. Chetan Das Priya Hotwani Dr. Suresh Kumar Rathi*. "FREQUENCY OF NECROTIZING ENTEROCOLITIS IN PRETERM NEONATES AND THEIR OUTCOME DURING HOSPITAL STAY." Indo American Journal of Pharmaceutical Sciences 04, no. 07 (2017): 2087–94. https://doi.org/10.5281/zenodo.835557.

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Background: Neonatal necrotizing enterocolitis [NEC], characterized by intestinal necrosis and pneumatosis intestinal, is the most common gastrointestinal emergency in the premature newborns[1] . The disease has an incidence rate of 2 to 5% in premature infants. The incidence rate increases to 13% in those weighing 1,500 gram at birth. NEC has a mortality rate of 10 to 55%. Objective: To determine the frequency of necrotizing enterocolitis in preterm neonates along with their outcome during stay in hospital. Methods: All premature newborn with morbidity admitted at Neonatal Intensive Care Unit

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Choi, Jun-Ho, Dong Seo, Tae Song, et al. "Long-term outcomes after endoscopic ultrasound-guided ablation of pancreatic cysts." Endoscopy 49, no. 09 (2017): 866–73. http://dx.doi.org/10.1055/s-0043-110030.

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Abstract Background and study aims The aim of this study was to investigate the long-term outcomes after endoscopic ultrasound (EUS)-guided pancreatic cyst ablation. Patients and methods In a single-center, prospective study, 164 patients with pancreatic cysts underwent EUS-guided cyst ablation using ethanol with paclitaxel. The inclusion criteria were as follows: unilocular or oligolocular cysts; clinically indeterminate cysts that required EUS fine-needle aspiration; and/or cysts that grew during the observation period. Treatment response was classified as complete resolution, partial resolu

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Dentali, Francesco, Marco Donadini, Benilde Cosmi, Alessandro Squizzato, Silvia Bozzato, and Walter Ageno. "Presence of Residual Thromboemboli at Least Six Months after a First Episode of Symptomatic Pulmonary Embolism: DO Perfusion Scintigraphy and CT-Angiography Agree?" Blood 112, no. 11 (2008): 3030. http://dx.doi.org/10.1182/blood.v112.11.3030.3030.

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Abstract Introduction. The natural history of residual thromboembolic obstructions after pulmonary embolism (PE) and the clinical utility of imaging techniques at follow up are not completely known; in particular, to our knowledge, there are no clinical studies that compared the accuracy of angio-computed tomography (angio-CT) and perfusion scintigraphy (Q scan) in detecting residual thromboemboli after at least 6 months from a first episode of symptomatic PE. Methods. Consecutive patients on anticoagulant treatment for a first episode of symptomatic PE diagnosed by angio-CT scan and/or Q scan

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Friedmann, Anton, Andreas Stavropoulos, and Hakan Bilhan. "GTR Treatment in Furcation Grade II Periodontal Defects with the Recently Reintroduced Guidor PLA Matrix Barrier: A Case Series with Chronological Step-by-Step Illustrations." Case Reports in Dentistry 2020 (December 16, 2020): 1–10. http://dx.doi.org/10.1155/2020/8856049.

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Molars with a furcation involvement (FI) exceeding grade 1 according to Hamp’s classification are at approximately doubled risk of tooth loss. Guided tissue regeneration (GTR) is a regenerative approach in the treatment of periodontal defects and is aimed at achieving new clinical attachment formation. The aim of this case series was to assess the efficacy of a newly reintroduced polylactic acid (PLA) matrix barrier and to evaluate the feasibility of the surgical approach. 11 patients with an average age of 58.7 years were treated with GTR using a PLA matrix barrier. Patients were instructed n

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Covut, Fahrettin, Tariq Zuheir Kewan, Oscar Perez, et al. "Direct oral anticoagulants (DOAC) versus warfarin and enoxaparin in ovarian vein thrombosis." Journal of Clinical Oncology 37, no. 15_suppl (2019): e14698-e14698. http://dx.doi.org/10.1200/jco.2019.37.15_suppl.e14698.

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e14698 Background: Ovarian vein thrombosis (OVT) is a rare condition that is commonly associated with malignancy. Efficacy and safety profile of DOAC in OVT has not been compared with warfarin and low-molecular-weight-heparin in the literature. Methods: We reviewed patients who were diagnosed with OVT between 11/2012 and 1/2018 and had follow-up imaging with computed tomography to assess resolution of thrombus. The outcomes of interests were thrombus resolution, recurrent thromboembolic events, and 1-year cumulative incidence of clinically significant bleeding events. Cumulative incidence was

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Lee, Dae-Hyoung, Young-Joo Kwon, Nak-Gyun Chung, Dae-Chul Jeong, Hack-Ki Kim, and Bin Cho. "Comparable Outcomes of High-Resolution HLA-Matched Unrelated and HLA-Identical Sibling Donor Stem Cell Transplantation for Childhood Acute Myeloid Leukemia in First Remission." Blood 110, no. 11 (2007): 5079. http://dx.doi.org/10.1182/blood.v110.11.5079.5079.

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Abstract Purpose: The role of allogeneic stem cell transplantation (SCT) from unrelated donor for childhood acute myeloid leukemia (AML) in first remission remains unclear because of its high transplant-related mortality. In this study, we investigated the role of SCT from high-resolution HLA-matched unrelated donor for childhood acute myeloid leukemia in first remission by comparing the outcomes of SCT from HLA-identical sibling donors and high-resolution HLA-matched unrelated donors. Patients and Method: Between June 2002 and August 2005, 40 children who have AML in first complete remission

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Srinivasan, Shreya, N. R. Vignesh, G. Sukanya, K. Manoharan, S. Gayathri, and R. N. Raksha. "A study comparing the efficacy of 25% podophyllin resin versus cryotherapy in the treatment of anogenital warts – What is old still holds good!" Indian Journal of Sexually Transmitted Diseases and AIDS 46, no. 1 (2025): 31–36. https://doi.org/10.4103/ijstd.ijstd_54_24.

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Abstract Context: Human papillomavirus types 6 and 11 are the most prevalent strains that produce anogenital warts. Both cryotherapy and podophyllin have approved modalities in the treatment of anogenital warts. Aim: The aim of this study was to determine the treatment outcome following cryotherapy compared to podophyllin in the treatment of anogenital warts. Settings and Design: This was an observational study conducted in a tertiary care hospital. Materials and Methods: All patients diagnosed clinically with anogenital warts were recruited after obtaining informed consent and with due consid

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Vis, M., K. Marc, I. Tchetverikov, J. Hazes, and J. Luime. "SAT0442 EVOLVEMENT OF SWOLLEN JOINTS IN THE FIRST YEAR OF EARLY PSORIATIC OLIGOARTHRITIS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1177.2–1178. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5850.

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Background:Oligoarthritis and polyarthritis are the predominant phenotypes in PsA. Previous we have shown that patients with oligoarthritis suffer a similar loss in quality of life as polyarthritis patients.1Although oligoarthritis is one of the most prevalent form, ample data is available on this phenotype.2-5Objectives:To evaluate the evolution of swollen joint count over the first year since diagnosis and to assess baseline difference in those groups that evolved differently over time.Methods:Our study is embedded in the Dutch south-west Early Psoriatic Arthritis (DEPAR) prospective cohort

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Miceli, Francesca, Ada Dajci, Alessia Di Girolamo, et al. "Early and Mid-Term Outcomes of Isolated Type 2 Endoleak Refractory to an Embolization Procedure." Journal of Clinical Medicine 14, no. 2 (2025): 502. https://doi.org/10.3390/jcm14020502.

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Introduction: A type 2 endoleak (EL2) remains the most prevalent complication of endovascular aortic repair (EVAR) for an abdominal aortic aneurysm (AAA). Methods: We conducted a retrospective, single-center analysis, including patients who underwent embolization for an isolated EL2 after EVAR. The study population was stratified into two groups: Group A, consisting of patients whose EL2 resolved after the first embolization procedure, and Group B, consisting of those with refractory EL2 (rEL2). The indication for EL2 treatment was aneurysmal sac growth amounting to >10 mm from the index EV

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Kristiyanti, Rini, Milatun Khanifah, Edy Subowo, and Nur Intan Kusuma. "Education for Pregnant Women and Cadres as an Effort to Optimize the Achievement of Exclusive Breastfeeding in Stunting Prevention." Prima Abdika: Jurnal Pengabdian Masyarakat 3, no. 4 (2023): 501–9. http://dx.doi.org/10.37478/abdika.v3i4.3396.

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Exclusive breastfeeding for the first six months of a baby's life is the gold standard in infant and child feeding recommended by WHO and UNICEF. Breast milk contains the complete nutrition that babies need. Only breastfeeding for infants aged 0-6 months is sufficient for all the nutritional needs of infants. This program aimed to increase mothers' understanding of the importance of exclusive breastfeeding, increase mothers' self-efficacy for breastfeeding, and mothers' readiness to face the breastfeeding process. The program is carried out by providing education, demonstrations, and breastfee

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Galimova, A. B., and V. U. Galimova. "Long-term results of anti-VEGF therapy in macular edema caused by central retinal vein occlusion." Russian Ophthalmological Journal 16, no. 4 (2023): 11–17. http://dx.doi.org/10.21516/2072-0076-2023-16-4-11-17.

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Purpose. To evaluate long-term results of anti-VEGF therapy performed in a modified “treat-and-extend” regimen in macular edema secondary to central retinal vein occlusion.Material and methods. The prospective study included 29 patients (16 men and 13 women) aged 24–81. The median follow-up period was 36 months [24; 60]. 20 patients underwent ranibizumab monotherapy, 3 patients – aflibercept monotherapy, while 6 patients received a combination of the two drugs following the modified regimen, which allowed terminating anti-VEGF treatment when macular edema remission was achieved.Results. Macula

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Finitsis, S., R. Anxionnat, S. Bracard, A. Lebedinsky, C. Marchal, and L. Picard. "Symptomatic Radionecrosis after AVM Stereotactic Radiosurgery." Interventional Neuroradiology 11, no. 1 (2005): 25–33. http://dx.doi.org/10.1177/159101990501100104.

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The purpose of our study was to analyze the outcome of symptomatic radionecrosis following stereotactic radiosurgery for brain arterio venous malformations. Of 225 patients treated by linear accelerator radiosurgery for brain AVM, 16 (7, 1%) presented post-radiosurgery symptomatic radionecrosis on a mean follow-up period of 50 months (range 1–123 months). Once diagnosed with radionecrosis, 14 of 16 patients were subjected to high dose corticotherapy consisting of escalating doses of dexamethasone for several weeks. The mean interval of occurrence of new symptoms was 11.6 months post-radiosurge

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Campbell, Jennifer, Dheeraj K. Rajan, John R. Kachura, et al. "Efficacy of Ovarian Artery Embolization for Uterine Fibroids." Canadian Association of Radiologists Journal 66, no. 2 (2015): 164–70. http://dx.doi.org/10.1016/j.carj.2014.08.005.

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Purpose The objective of the study was to assess the efficacy of ovarian artery embolization (OAE) treatment for symptomatic uterine leiomyomas. Methods A retrospective review of 17 patients who underwent OAE in conjunction with uterine artery embolization in a 6-year period (2006-2012) was performed. Ten patients had previous failed embolization, while 7 had not received any embolization therapy before. Percent uterine volume change, percent dominant fibroid volume change, and percent dominant fibroid infarction were assessed with magnetic resonance (MR) imaging. Resolution of menorrhagia, dy

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Bastemur, Mehmet, Rahsan Gocmen, Safak Parlak, et al. "Pontine Tegmentum Lesions Accompanying Myelitis During an Enterovirus Outbreak: Differential Diagnosis and Outcome." Journal of Child Neurology 35, no. 8 (2020): 501–8. http://dx.doi.org/10.1177/0883073820911737.

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Aim: To investigate etiology and prognostic significance of pontine tegmentum lesions accompanying a cluster of acute flaccid myelitis. Method: We retrospectively examined patients from 6 centers in Turkey who manifested encephalitis or myelitis associated with dorsal pontine lesions on magnetic resonance imaging (MRI) between July 2018 and February 2019. Results: Twenty-two patients were evaluated. Ten of 22 (45%) presented with acute paralysis and 12 of 22 (55%) with brainstem symptoms only. Reverse transcription polymerase chain reaction for enterovirus was positive in 2 patients’ respirato

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Sunita Bharati, Kumari, Sanjeet Kumar Singh, Kalpana Chandra, Zaheer Hasan, and Umakant Prasad. "HISTOMORPHOLOGICAL FINDINGS AND CLINICO-RADIOLOGICAL CORRELATION OF INTESTINAL ATRESIA AT A TERTIARY CARE CENTRE." International Journal of Advanced Research 9, no. 12 (2021): 716–24. http://dx.doi.org/10.21474/ijar01/13964.

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Background: An atresia is a congenital defect of a hollow viscus that results in complete obstruction of the lumen. Intestinal atresia is one of the most frequent causes of bowel obstruction in the newborn and can occur at any point in the gastrointestinal tract. This study was undertaken to study the histomorphological findings of intestinal atresia and to correlate it with different subtypes and clinico-radiological feature. Material and methods: This was a prospective observational study conducted in 24 months on the resected gastrointestinal tract of 40 neonatal intestinal obstruction case

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Hamid, F., A. Afroza, and PC Ray. "Aetio-Clinical Profile of Cholestatic Jaundice During Infancy- Study of 30 Cases in a Tertiary Care Hospital." Bangladesh Medical Journal 41, no. 2 (2014): 34–39. http://dx.doi.org/10.3329/bmj.v41i2.18804.

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Cholestasis in young infants has a varied etiology. There is considerable delay in presentation of cholestatic cases, both in India (average delay of 3 months in referral centers) and Bangladesh (3.5 months). Early diagnosis is important as the effects of cholestasis are profound and wide-spread. EHBA comprises a significant proportion of cases of cholestatic diseases. If treatment of EHBA is delayed beyond the first 90 days of life, the only option thereafter is liver transplantation, which is not presently feasible on a large scale in developing countries. So, the aim and objective of this s

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Vassallo, Fabricio. "Prevalence and Resolution of Resistant Left Atrial Appendage Thrombus in Non-Valvular Atrial Fibrillation Patients Submitted to Percutaneous Interventions." Clinical Cardiology and Cardiovascular Interventions 4, no. 8 (2021): 01–09. http://dx.doi.org/10.31579/2641-0419/161.

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Introduction: Left atrial appendage (LAA) thrombus in atrial tachyarrhythmias is one of the principal causes of stroke. Prevalence and strategies to thrombus resolution has recently been described in the era of the direct oral anticoagulants (DOAC). The aim of the study was to determine the prevalence and strategies to resolve previous LAA thrombus during regular oral antithrombotic therapy in preparation to perform atrial fibrillation (AF) ablation and/or LAA closure. Methods: Between January 2011 and December 2020 we prospectively followed 23 patients (5.39%) that showed LAA thrombus formati

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Gabal, M. A. "Pathogenesis and electron microscopic changes of spherulogenesis of Coccidioides immitis (valley fever)." American Journal of Veterinary Research 46, no. 3 (1985): 671–75. https://doi.org/10.2460/ajvr.1985.46.03.671.

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SUMMARY Pathogenesis and electron microscopic changes of spherulogenesis of Coccidioides immitis were determined. The organism showed a strong affinity for lung tissue, with granuloma developing in 100% (n = 40) of animals after subcutaneous and intraperitoneal inoculation. Intranasal instillation of the arthrospores resulted in moderate granuloma, with a markedly low frequency rate of infection in 11 animals (55%). Intradermal inoculation and skin scarification did not induce systemic infection. Unlike other routes used to induce infection, only 30% of the mice showed cutaneous changes, where

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Martabano, Brittany B., Steven Dow, Lyndah Chow, et al. "Intralesional interferon alpha-2b as a novel treatment for periocular squamous cell carcinoma in horses." PLOS ONE 19, no. 2 (2024): e0297366. http://dx.doi.org/10.1371/journal.pone.0297366.

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Objective To determine the safety and efficacy of perilesional human recombinant interferon alpha-2b (IFNα2b) for treatment of periocular squamous cell carcinoma (PSCC) in horses. Animals studied Eleven horses (12 eyes) with PSCC were enrolled in this prospective clinical study with owner consent. Procedures Systemically healthy horses were included in the study following confirmation of PSCC via biopsy. Every two weeks for a maximum of six treatments, horses were sedated and perilesional injection of IFNα2b (10 million IU) was performed. Tumors were measured prior to each injection and at one

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Kwon, Seung Yeon, Sung Chul Won, Hyo Sun Kim, et al. "Aberrant DNA Methylation in Childhood Acute Lymphoblastic Leukemia as a Potential Biomarker Reflecting Disease Status." Blood 114, no. 22 (2009): 2637. http://dx.doi.org/10.1182/blood.v114.22.2637.2637.

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Abstract Abstract 2637 Poster Board II-613 Background: Aberrant DNA methylation of promoter-associated cystosine-guanine (CpG) islands is known to play an important role in leukemogenesis and has been reported to have association with poor prognosis in acute lymphoblastic leukemia (ALL). In adult, residual methylation at clinical remission status in patients with acute myeloid leukemia and Philadelphia chromosome-positive ALL showed significant association with poor prognosis in recent studies. We analyzed 47 patients with childhood ALL to evaluate the change of methylation status from the tim

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Luciani, Matteo, May El Hachem, Andrea Diociaiuti, et al. "Rivaroxaban in Paediatric Venous Malformations: Preliminary Data from a Retrospective Single-Center Study." Blood 144, Supplement 1 (2024): 1253. https://doi.org/10.1182/blood-2024-204882.

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Background and Aims: Venous malformations (VMs) are the most frequent type among congenital vascular malformations, with an incidence between 0.8-1%. VMs can be cutaneous and extracutaneous, single or multiple; typically, VMs appear from birth, show progressive growth and persist throughout life. They require a multidisciplinary approach to ensure early diagnosis and prevent or treat any complications. We report preliminary data from our center's experience with the use of rivaroxaban in pediatric venous malformations complicated by thrombosis. Methods: We conducted a retrospective observation

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Fam, Maged D., Royce W. Woodroffe, Logan Helland, et al. "Spinal arachnoid cysts in adults: diagnosis and management. A single-center experience." Journal of Neurosurgery: Spine 29, no. 6 (2018): 711–19. http://dx.doi.org/10.3171/2018.5.spine1820.

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OBJECTIVEAdult spinal arachnoid cysts (SACs) are rare entities of indistinct etiology that present with pain or myelopathy. Diagnosis is made on imaging studies with varying degrees of specificity. In symptomatic cases, the standard treatment involves surgical exploration and relief of neural tissue compression. The aim of this study was to illustrate features of SACs in adults, surgical management, and outcomes.METHODSThe authors searched medical records for all SACs in adults in the 10-year period ending in December 2016. Radiology and pathology reports were reviewed to exclude other spine c

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Novegno, Federica, Massimo Caldarelli, Antonio Massa, et al. "The natural history of the Chiari Type I anomaly." Journal of Neurosurgery: Pediatrics 2, no. 3 (2008): 179–87. http://dx.doi.org/10.3171/ped/2008/2/9/179.

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Object Since the advent of MR imaging, an increasing number of asymptomatic or oligosymptomatic patients have been diagnosed with Chiari malformation Type I (CM-I). The decision of whether or not to operate is more difficult in these patients than in those with clear symptoms because of the lack of information about the natural course of this disease. Methods The authors report on their experience in a series of 22 patients with CM-I who were evaluated at the authors' institution, and for whom a conservative approach to treatment was adopted. The patients ranged in age from 1 to 16 years (mean

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Terpos, Evangelos, Maria Gavriatopoulou, Ioannis Ntanasis-Stathopoulos, et al. "Safety and clinical activity of belantamab mafodotin plus lenalidomide and dexamethasone in transplant ineligible patients with newly diagnosed multiple myeloma: The phase 1/2, prospective, open-label, BelaRd study." Journal of Clinical Oncology 41, no. 16_suppl (2023): 8050. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.8050.

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8050 Background: We present the updated safety and efficacy of upfront belantamab mafodotin (belamaf) plus lenalidomide and dexamethasone (Rd) in transplant ineligible (TI) pts with newly diagnosed multiple myeloma (NDMM). Methods: The ongoing, prospective, open-label, phase 1/2 BelaRd study (NCT04808037) aims to enroll 66 pts with TI NDMM, with ECOG PS < 2 and adequate organ function. In Part 1, 36 pts are randomized (1:1:1) to receive belamaf 2.5, 1.9, or 1.4 mg/kg Q8W plus Rd. Eye exams include Snellen best corrected visual acuity (BCVA) and corneal exam (slit lamp examination). Ocular a

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Nunes Rodrigues, Tania C., Laura R. Stroobants, and Sophie I. Vandenabeele. "Feline cutaneous nodular and ocular Cryptococcus neoformans in Belgium." Journal of Feline Medicine and Surgery Open Reports 6, no. 1 (2020): 205511692091256. http://dx.doi.org/10.1177/2055116920912560.

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Case summary An 11-year-old spayed female cat presented with a 6-month history of a progressive nodular skin disease with concurrent, ocular lesions, intermittent vomiting, halitosis and weight loss. The cat had received different topical treatments without success prior to referral to the Dermatology Department of Faculty of Veterinary Medicine, Ghent University. Several fine-needle aspirations of the lesions showed a vast number of macrophages with intra-cytoplasmic inclusions compatible with Cryptococcus species. Histopathological examination revealed pyogranulomatous inflammation with caps

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Riaz, Nadeem, Eric Jeffrey Sherman, Nora Katabi, et al. "A personalized approach using hypoxia resolution to guide curative-intent radiation dose-reduction to 30 Gy: A novel de-escalation paradigm for HPV-associated oropharynx cancers (OPC)." Journal of Clinical Oncology 35, no. 15_suppl (2017): 6076. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.6076.

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6076 Background: We conducted a pilot study using functional imaging to guide reduction in radiation (RT) to 30Gy with concurrent chemotherapy in patients with HPV+ OPC. Methods: 19 patients were enrolled prospectively from 7/2015-10/2016. Primary tumors were excised and analyzed for DNA repair foci ex-vivo. A pre-RT dynamic 18F-FMISO (fluoromisonidazole) PET was then used to assess tumor hypoxia (defined as > 1.2 tumor to muscle SUV ratio) in cervical lymph nodes. Patients without hypoxia on baseline or repeat scan done 5-10 days after initiation of chemoRT received 30Gy (57% reduction) ov

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Amir, Sadida, Shakil Ahmad, Muhammad Usman, Imran Sarwar, Nisar Khan Sajid, and Tanveer Ahmad. "Role of Oral Iron Supplementation in Reducing Breath-Holding Attacks in Children under five years." Journal of Aziz Fatimah Medical & Dental College 3, no. 1 (2021): 3–7. http://dx.doi.org/10.55279/jafmdc.v3i1.112.

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Objective: To evaluate the effect of oral iron supplementation in the reduction of severity and frequency of breath-holding spells(BHAs) in children under five years.Methodology: This prospective interventional study included 50 patients aged 6 to 60 months with breath-holding attacks and concomitant iron deficiency anemia. It was conducted at independent medical college, from December 2012 to March 2013 after taking ethical approval. All information concerning it was recorded on predesigned proforma and anemia was determined in lab investigation. All patients prescribed oral elemental iron at

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Miller, K., L. S. Rosen, S. Modi, et al. "Phase I trial of alvespimycin (KOS-1022; 17-DMAG) and trastuzumab (T)." Journal of Clinical Oncology 25, no. 18_suppl (2007): 1115. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.1115.

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1115 Background: Alvespimycin (A) inhibits the activity of Hsp90, resulting in degradation of client proteins, such as the HER2 receptor. In vivo, Hsp90 inhibition induces rapid degradation of HER2 with loss of pAKT, cyclin D2 and tumor growth inhibition. Methods: Pts receive standard weekly doses of T followed by A in escalating doses via IV doses over 1 hr. Define the recommended dose (RP2D), toxicity and signs of activity of T+A in pts with solid tumors. PK: assessed after the 1st and 4th infusion. PBLs: purified to investigate changes in intracellular signaling proteins by immunoblot. The

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Ansell, Stephen M., David J. Straus, Joseph M. Connors, et al. "Seven-year overall survival analysis from ECHELON-1 study of A+AVD versus ABVD in patients with previously untreated stage III/IV classical Hodgkin lymphoma." Journal of Clinical Oncology 42, no. 16_suppl (2024): 7053. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.7053.

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7053 Background: In ECHELON-1 (NCT01712490), 6-year follow-up (FU) analyses demonstrated significant improvements in overall survival (OS) and progression-free survival (PFS) with A+AVD (brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine) versus ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine), with a comparable safety profile. Here, we report data at 7-year median FU. Methods: Analyses of OS and PFS per investigator were conducted in the intent-to-treat (ITT) population (data cut-off March 11, 2023). Patients (pts) were randomized 1:1 to receive ≤6 cycles of A+AVD (

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Koo, Bon Kwon, Won-Heum Shim, Young-Sup Yoon, et al. "Endovascular Therapy Combined with Immunosuppressive Treatment for Pseudoaneurysms in Patients with Behçet's Disease." Journal of Endovascular Therapy 10, no. 1 (2003): 75–80. http://dx.doi.org/10.1177/152660280301000116.

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Purpose: To evaluate the feasibility, efficacy, and outcome of endovascular therapy combined with immunosuppression for the treatment of arterial pseudoaneurysms due to Behçet's disease. Methods: Eleven pseudoaneurysms (3 in the abdominal aorta, 3 in the subclavian artery, and individual lesions in the brachiocephalic artery, renal artery, common iliac artery, common carotid artery, and the descending thoracic aorta) in 9 patients with Behçet's disease were treated with 10 stent-grafts and 1 self-expanding stent. All patients with elevated erythrocyte sedimentation rate (ESR) were treated with

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Somers, Judith AE, Yvette van Hensbergen, Anneke Brand, et al. "Early Engraftment Kinetics of Leukocyte Subsets by Means of HLA-Specific Mabs After Double Umbilical Cord Blood Transplantation Show a Very Rapid Induction of Single Complete Donor Chimerism." Blood 114, no. 22 (2009): 3338. http://dx.doi.org/10.1182/blood.v114.22.3338.3338.

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Abstract Abstract 3338 Poster Board III-226 Double umbilical cord blood transplantation (UCBT) results in higher engraftment rates as compared to single UCBT in adult patients. Sustained hematopoiesis is usually derived from a single cord blood unit (CBU). So far, the mechanism of predominance of a particular CBU is unresolved. Immunological rejection of one CBU has been proposed, as well as a selective growth advantage of one particular unit. Frequent serial chimerism studies in leukocyte subsets by use of HLA-specific monoclonal antibodies (mAbs) during the first month post transplant might

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Joshi, Anagha Atul, Bhagyashri Ganesh Chiplunkar, Renuka Anil Bradoo, and Kshitij Dhaval Shah. "Posterior Commissure Hypertrophy as Diagnostic and Prognostic Indicator for Laryngopharyngeal Reflux." International Journal of Phonosurgery & Laryngology 5, no. 2 (2015): 57–60. http://dx.doi.org/10.5005/jp-journals-10023-1106.

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ABSTRACT Purpose To establish posterior commissure hypertrophy as tool to diagnose laryngopharyngeal reflux (LPR) and to determine whether it can be used as a reliable marker for response to treatment. Materials and methods A prospective study of 100 patients with voice disorder was conducted. Patients were evaluated using reflux symptom index (RSI) and reflux finding score (RFS) by 70° Hopkins’ rigid laryngoscope. Those patients in whom RFS score was 7 or more were diagnosed to have LPR. These patients were then started on antireflux therapy along with lifestyle modification and were evaluate

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Stanford, Sarah, Zeni Kharel, Lauryn Hemminger, et al. "Abstract PO4-20-11: Excellent Response to Trastuzumab Deruxtecan in “HER-2 Low” Leptomeningeal Breast Cancer and Diagnostic and Monitoring Utility of CNSide Assay." Cancer Research 84, no. 9_Supplement (2024): PO4–20–11—PO4–20–11. http://dx.doi.org/10.1158/1538-7445.sabcs23-po4-20-11.

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Abstract A 72-year-old female presented to the emergency department with sudden onset of imbalance and cognitive decline. Two years ago, she was diagnosed with stage III estrogen receptor (ER) positive, progesterone receptor (PR) negative and human epidermal growth factor receptor 2 (HER2) negative (immunohistochemistry score: 0) invasive breast cancer. She subsequently underwent lumpectomy, adjuvant radiation and chemotherapy. She had been taking adjuvant letrozole at the time of presentation. Magnetic resonance imaging (MRI) of the brain showed obstructive hydrocephalus without any parenchym

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Gonzalez Corcia, M. Cecilia, Adrien Bottosso, Isabelle Loeckx, Françoise Mascart, Guy Dembour, and Geneviève François. "Efficacy of treatment with belladonna in children with severe pallid breath-holding spells." Cardiology in the Young 28, no. 7 (2018): 922–27. http://dx.doi.org/10.1017/s1047951118000458.

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AbstractIntroductionPallid breath-holding spells are common and dramatic forms of recurrent syncope in infancy. They are very stressful despite their harmless nature and sometimes require treatment.ObjectiveThe objective of this study was to evaluate the efficacy of belladonna in severe breath-holding spells.MethodsThis is a multicentric, retrospective series involving 84 children with severe pallid breath-holding spells. Inclusion criteria were >1 pallid breath-holding spell with loss of consciousness, paediatric cardiology evaluation, and follow-up >6 months. In total, 45 patients rece

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Mahapatra, Manoranjan, Rajat Kumar, Pravas P. Mishra, Renu Saxena, Hara P. Pati, and Ved Prakash Choudhry. "Role of Radiotherapy in Hemophiliac Pseudotumors: An Experience from India." Blood 106, no. 11 (2005): 3221. http://dx.doi.org/10.1182/blood.v106.11.3221.3221.

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Abstract Introduction: Pseudotumours are rare and serious complications of hemophilia, occurring in approximately 1% to 2% of patients. They are thought to be the result of recurrent hemorrhage into the muscles or periosteal or intraosseous spaces and consist of a tough, fibrous capsule surrounding a chronically enlarged coagulum. Material and methods: Over a period of 10 years (1995–2004) 585 hemophilia patients were studied retrospectively to identify the cases of pseudotumours. Pseudotumours were confirmed on standard clinical and radiological criteria. The treatment modalities used either

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Amaya-Chanaga, Carlos I., Michael Y. Choi, Natalie Nguyen, et al. "A Phase Ib/II Study of Ibrutinib in Combination with Obinutuzumab-Gazyva As First-Line Treatment for Patients with Chronic Lymphocytic Leukemia > 65 Years Old or with Coexisting Conditions." Blood 128, no. 22 (2016): 2048. http://dx.doi.org/10.1182/blood.v128.22.2048.2048.

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Abstract Standard treatment for patients (pts) with chronic lymphocytic leukemia (CLL) is rapidly evolving and gradually has incorporated the use of monoclonal antibodies (mAbs) and targeted therapy with small molecules. Single agent Ibrutinib (a first-in-class BTK inhibitor) has shown to be effective in previously untreated (PU) pts including those that are older than 65 or considered unfit to receive chemotherapy-based combinations. The response rate could be higher in pts receiving ibrutinib (overall response of 71% and complete response of 13%) but the mobilization of lymphocytes, which is

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Zeng, Xiaopei Lily, and Sherif M. Badawy. "Evaluating Clinical Outcomes and Potential Prognostic Factors Among 308 Children and Adolescents with Immune Thrombocytopenia (ITP): An 11-Year Retrospective Cohort Study." Blood 138, Supplement 1 (2021): 4053. http://dx.doi.org/10.1182/blood-2021-154344.

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Abstract Background: Immune thrombocytopenia (ITP) usually is a mild and self-limited disease; however, 25-30% of children develop chronic ITP. Nordic score is a validated clinical prediction tool, yet its use in children is limited and evidence for other prognostic factors is unclear. Purpose: To evaluate clinical outcomes among pediatric ITP patients, and examine their relationship to patient characteristics, including Nordic score. We hypothesized that Nordic score and patient characteristics will be predictive of ITP resolution or development of chronic ITP. Methods: We conducted a retrosp

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Yang, Hee Seok, Jeong Woo Kim, Sung Hyun Lee, and Byung Min Yoo. "Comminuted Radial Head Fracture in All-arthroscopic Repair of Elbow Fracture-dislocation: Is Partial Excision of the Radial Head an Acceptable Treatment Option?" Clinics in Shoulder and Elbow 21, no. 4 (2018): 234–39. http://dx.doi.org/10.5397/cise.2018.21.4.234.

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BACKGROUND: In elbow fracture-dislocation, partial excision of the comminuted radial head fracture that is not amenable to fixation remains controversial considering the accompanying symptoms. This study was undertaken to evaluate the results of radial head partial excision when the comminuted radial head fracture involved < 50% of the articular surface in all-arthroscopic repair of elbow fracture-dislocation.METHODS: Patients were divided into two groups based on the condition of the radial head fracture. In Group A, the patients had a radial head comminuted fracture involving < 50% of

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Gladman, Dafna D., Olga Ziouzina, Arane Thavaneswaran, and Vinod Chandran. "Dactylitis in Psoriatic Arthritis: Prevalence and Response to Therapy in the Biologic Era." Journal of Rheumatology 40, no. 8 (2013): 1357–59. http://dx.doi.org/10.3899/jrheum.130163.

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Objective.To determine the prevalence of acute dactylitis in patients with psoriatic arthritis (PsA) and to compare the response of new acute dactylitis to treatment with traditional disease-modifying antirheumatic drug (DMARD) and anti-tumor necrosis factor-α (anti-TNF) agents in a longitudinal PsA cohort.Methods.Patients with PsA followed at 6 months according to a standard protocol from January 2000 to January 2010 were included in our study. Acute dactylitis was defined as the presence of painful swelling of an entire digit. Response was defined as either complete resolution of dactylitis

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Matthias Corvinus, Florian, Edin Hadzijusufovic, Benjamin Babic, Hauke Lang, and Peter Grimminger. "PS01.049: ENDOSTIM™ NON-RESPONDERS: AN ANALYSIS." Diseases of the Esophagus 31, Supplement_1 (2018): 63–64. http://dx.doi.org/10.1093/dote/doy089.ps01.049.

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Abstract Background Electronic stimulation oft the lower esophageal sphincter (LES) is a new promising anti-reflux procedure that is established in Germany since 2014. Basically two leads are inserted laparoscopicaly into the LES and connected to an implantable pulse generator (IPG) which is placed in a subcutaneous pocket. This stimulation is supposed to build up the muscular anti-reflux barrier. It is limited to patients with a small hiatal hernia < 3 cm and reflux esophagitis LA Classification Type A-C. Although long-term results up to 4 years with a good postoperative reflux control and

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Pelland-Marcotte, Marie-Claude, Tasha Cusson, Jessica Giguère, Émilie Martineau, Chantal Ethier, and André Lamarre. "Clinical Significance of Incidental Central Venous Catheter-Related Thrombosis in Children Previously Treated for Cancer." Blood 144, Supplement 1 (2024): 2623. https://doi.org/10.1182/blood-2024-194341.

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Background: Up to 50% of children with cancer may develop clinically unsuspected venous thrombo-embolisms (VTE), most related to an underlying central venous catheter (CVC). Whether clinically unsuspected and symptomatic VTEs are associated with similar long-term clinical impacts in children with cancer is controversial. Aims:To describe the proportion of patients with post-thrombotic syndrome (PTS) and with residual vascular occlusion among children previously treated for cancer and who required a CVC. Methods:This cross-sectional study included 50 consecutive children aged 1-18 years old pre

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Stamouli, Maria, Ioannis Tsonis, Konstantinos Gkirkas, et al. "Oral Ribavirin with or without the Addition of Immune Globulin for the Treatment of Lower Respiratory Tract Infections Due to Respiratory Syncytial Virus or Parainfluenza in Patients after Allogeneic Stem Cell Transplantation." Blood 134, Supplement_1 (2019): 4498. http://dx.doi.org/10.1182/blood-2019-128362.

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Introduction Lower respiratory tract infections (LRTI) due to parainfluenza (PIF) or respiratory syncytial virus (RSV) represent a major challenge for immunocompromised patients especially those after allogeneic stem cell transplantation (allo-SCT). Evidence-based guidelines for the management of respiratory virus infections in allo-SCT recipients are limited due to the paucity of effective antivirals and the lack of prospective randomized trials. In this study, we report our experience with the use of oral ribavirin with or without the addition of IVIgG in allo-SCT recipients with LTRI due to

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Venmathi Maran, Balu Alagar, Kishneth Palaniveloo, Thivyalaxmi Mahendran, et al. "Antimicrobial Potential of Aqueous Extract of Giant Sword Fern and Ultra-High-Performance Liquid Chromatography–High-Resolution Mass Spectrometry Analysis." Molecules 28, no. 16 (2023): 6075. http://dx.doi.org/10.3390/molecules28166075.

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Vibriosis and parasitic leech infestations cause the death of various farmed fish, such as groupers, hybrid groupers, sea bass, etc., in Malaysia and other Southeast Asian countries. In the absence of natural control agents, aquaculture operators rely on toxic chemicals to control Vibrio infections and parasitic leeches, which can have a negative impact on the environment and health. In the present study, we investigated the antivibrio and antiparasitic activities of the aqueous extract of giant sword fern (GSF) (Nephrolepis biserrata, Nephrolepidaceae, locally known as “Paku Pedang”) against

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Miller, Neil R., Lee H. Monsein, Gerard M. Debrun, Rafael J. Tamargo, and Haring J. W. Nauta. "Treatment of carotid-cavernous sinus fistulas using a superior ophthalmic vein approach." Journal of Neurosurgery 83, no. 5 (1995): 838–42. http://dx.doi.org/10.3171/jns.1995.83.5.0838.

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✓ The authors describe the method and results of treatment of 12 consecutive patients with carotid-cavernous sinus fistulas (CCFs). Treatment was by embolization via a transvenous approach through the superior ophthalmic vein (SOV). The CCFs (two direct and 10 dural) had previously been treated unsuccessfully or, for mechanical reasons, could not be treated by the standard techniques of endoarterial balloon occlusion, particle or glue embolization of feeding vessels from one or both external carotid arteries, or transvenous occlusion of the fistula via the ipsilateral inferior petrosal sinus.

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Shrestha, Aashish, Bikram Prasad Gajurel, Ragesh Karn, et al. "Low-volume Plasma Exchange In Immune-mediated Neurological Diseases : A tertiary care center study." Nepal Mediciti Medical Journal 3, no. 2 (2022): 54–58. http://dx.doi.org/10.3126/nmmj.v3i2.52363.

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BACKGROUND The optimal cost benefit of standard plasma exchange (SPE) has not been met where most of the patients do not afford the treatment. As an alternative, low volume plasma exchange (LVPE) is cost-effective than SPE where albumin replacement is eliminated. The aim of this study was to analyse the efficacy and safety of LVPE in various Immune mediated neurological diseases (IMND). METHODS A hospital-based retrospective study was conducted in patients with IMND who were admitted in TUTH between October 15, 2020, and October 14, 2022. Hemodynamically stable patients over the age of 1

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Skipper, Kent, Scott Sligh, Ernest Dunn, and Armond Schwartz. "Laparoscopic Cholecystectomy for an Abnormal Hepato-lminodiacetic Acid Scan: A Worthwhile Procedure." American Surgeon 66, no. 1 (2000): 30–32. http://dx.doi.org/10.1177/000313480006600106.

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Patients with symptoms similar to symptomatic cholelithiasis but with no sonographic evidence of gallstones can be difficult to manage. Cholecystokinin (CCK)-stimulated hepatobiliary scans can be helpful in determining whether the biliary tract is the potential source of the symptoms. We retrospectively reviewed the medical records of 69 patients at our institution who underwent CCK-stimulated hepatobiliary scans over a 2-year period. Twenty-nine of 69 patients had an abnormal gallbladder ejection fraction (defined as 35% or less). All 29 patients had no sonographic evidence of cholelithiasis.

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Emanuelli, Enzo, Giuliana Frasson, Diego Cazzador, Daniele Borsetto, and Luca Denaro. "Endoscopic Transsphenoidal Salvage Surgery for Symptomatic Residual Cystic Craniopharyngioma after Radiotherapy." Journal of Neurological Surgery Part B: Skull Base 79, S 03 (2018): S256—S258. http://dx.doi.org/10.1055/s-0038-1636504.

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Objectives Ideal treatment of craniopharyngiomas is still controversial. Radiotherapy (RT) is considered effective for recurrences or after subtotal tumor removal (STR). About 40 to 50% of patients may experience tumor cyst expansion soon after RT; in these cases, the role of salvage surgery is debated. Design Operative video. Setting Tertiary care center. Participants An 11-year-old boy diagnosed with persistent craniopharyngioma. In 2015, the patient underwent right frontotemporal craniotomy for STR at another center, complicated by panhypopituitarism. Two years later, fractionated 54-Gy RT

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Aldarweesh, Mariam, Fatima Khadadah, Eman Alazmi, et al. "Acute Lymphocytic Leukemia (ALL) in Pregnancy, Case Report and Literature Review." Blood 142, Supplement 1 (2023): 5814. http://dx.doi.org/10.1182/blood-2023-189682.

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Introduction: Leukemia is rare in pregnancy, occurring in up to 1 in 100,000 pregnancies. A 28F G2P1 was diagnosed at our institution with Philadelphia (Ph) negative B-ALL at 24 weeks' gestation. She was induced with UKALL14 and achieved a flow negative complete remission post-induction. During induction chemotherapy, regular ultrasound scans showed that the fetus was growing normally for gestational age. The patient was kept on weekly vincristine and prednisone and had an elective c-section at 31+3 weeks, in light of her previous caesarean section, poor bishop score, and in order for her to s

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Andersson, Jafet C. M., Jonas Olsson, Remco (C Z. ). van de Beek, and Jonas Hansryd. "OpenMRG: Open data from Microwave links, Radar, and Gauges for rainfall quantification in Gothenburg, Sweden." Earth System Science Data 14, no. 12 (2022): 5411–26. http://dx.doi.org/10.5194/essd-14-5411-2022.

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Abstract. Accurate rainfall monitoring is critical for sustainable societies and yet challenging in many ways. Opportunistic monitoring using commercial microwave links (CMLs) in telecommunication networks is emerging as a powerful complement to conventional gauges and weather radar. However, CML data are often inaccessible or incomplete, which limits research and application. Here, we aim to reduce this barrier by openly sharing data at 10 s resolution with true coordinates from a pilot study involving 364 bi-directional CMLs in Gothenburg, Sweden. To enable further comparative analyses, we a

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Arnold, Paul M., Philip L. Johnson, and Karen K. Anderson. "Surgical management of multiple thoracic disc herniations via a transfacet approach: a report of 15 cases." Journal of Neurosurgery: Spine 15, no. 1 (2011): 76–81. http://dx.doi.org/10.3171/2011.3.spine10642.

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Object Symptomatic thoracic disc herniations (TDHs) are rare, and multiple TDHs account for an even smaller percentage of symptomatic herniated discs. Most TDHs are found in the lower thoracic spine, with more than 75% occurring below T-8. The authors report a series of 15 patients with multiple symptomatic TDHs treated with a modified transfacet approach. Methods Fifteen patients (9 women and 6 men) with a total of 32 symptomatic TDHs were treated surgically at the authors' institution between 1994 and 2010. The average patient age was 51.1 years. Thirteen patients had 2-level herniation and

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