Academic literature on the topic '11-hydroxy-tetrahydrocannabinol'

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Journal articles on the topic "11-hydroxy-tetrahydrocannabinol"

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Hassenberg, Christoph, Florian Clausen, Grete Hoffmann, Armido Studer та Jennifer Schürenkamp. "Investigation of phase II metabolism of 11-hydroxy-Δ-9-tetrahydrocannabinol and metabolite verification by chemical synthesis of 11-hydroxy-Δ-9-tetrahydrocannabinol-glucuronide". International Journal of Legal Medicine 134, № 6 (2020): 2105–19. http://dx.doi.org/10.1007/s00414-020-02387-w.

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Abstract (−)-Δ-9-tetrahydrocannabinol ((−)-Δ-9-THC) is the main psychoactive constituent in cannabis. During phase I metabolism, it is metabolized to (−)-11-hydroxy-Δ-9-tetrahydrocannabinol ((−)-11-OH-Δ-9-THC), which is psychoactive, and to (−)-11-nor-9-carboxy-Δ-9-tetrahydrocannabinol ((−)-Δ-9-THC-COOH), which is psychoinactive. It is glucuronidated during phase II metabolism. The biotransformation of (−)-Δ-9-tetrahydrocannabinol-glucuronide ((−)-Δ-9-THC-Glc) and (−)-11-nor-9-carboxy-Δ-9-tetrahydrocannabinol-glucuronide ((−)-Δ-9-THC-COOH-Glc) is well understood, which is mainly due to the ava
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Franz, Thomas, Gisela Skopp, Gerlinde Schwarz, and Frank Musshoff. "Proof of active cannabis use comparing 11-hydroxy-∆9-tetrahydrocannabinol with 11-nor-9-carboxy-tetrahydrocannabinol concentrations." Drug Testing and Analysis 10, no. 10 (2018): 1573–78. http://dx.doi.org/10.1002/dta.2415.

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Goodwin, Robert S., Richard A. Gustafson, Allan Barnes, Wesenyalsh Nebro, Eric T. Moolchan, and Marilyn A. Huestis. "??9-Tetrahydrocannabinol, 11-Hydroxy-??9-Tetrahydrocannabinol and 11-Nor-9-Carboxy-??9-Tetrahydrocannabinol in Human Plasma After Controlled Oral Administration of Cannabinoids." Therapeutic Drug Monitoring 28, no. 4 (2006): 545–51. http://dx.doi.org/10.1097/00007691-200608000-00010.

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Tynon, Marykathryn, Marcellino Porto, and Barry K. Logan. "Simplified Analysis of 11-Hydroxy-Delta-9-Tetrahydrocannabinol and 11-Carboxy-Delta-9-Tetrahydrocannabinol in Human Meconium: Method Development and Validation." Journal of Analytical Toxicology 39, no. 1 (2014): 35–40. http://dx.doi.org/10.1093/jat/bku107.

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Maralikova, Barbora, та Wolfgang Weinmann. "Simultaneous determination ofΔ9-tetrahydrocannabinol, 11-hydroxy-Δ9-tetrahydrocannabinol and 11-nor-9-carboxy-Δ9-tetrahydrocannabinol in human plasma by high-performance liquid chromatography/tandem mass spectrometry". Journal of Mass Spectrometry 39, № 5 (2004): 526–31. http://dx.doi.org/10.1002/jms.616.

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Abraham, T. T., R. H. Lowe, S. O. Pirnay, W. D. Darwin, and M. A. Huestis. "Simultaneous GC-EI-MS Determination of 9-Tetrahydrocannabinol, 11-Hydroxy- 9-Tetrahydrocannabinol, and 11-nor-9-Carboxy- 9-Tetrahydrocannabinol in Human Urine Following Tandem Enzyme-Alkaline Hydrolysis." Journal of Analytical Toxicology 31, no. 8 (2007): 477–85. http://dx.doi.org/10.1093/jat/31.8.477.

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Yamamoto, Ikuo, Kazuhito Watanabe, Shizuo Narimatsu, Koichi Hamajima та Hidetoshi Yoshimura. "Cross-tolerance to the hypothermic effect of Δ8-tetrahydrocannabinol 11-hydroxy-Δ8-tetrahydrocannabinol and chlorpromazine in the mouse". European Journal of Pharmacology 111, № 2 (1985): 159–66. http://dx.doi.org/10.1016/0014-2999(85)90752-6.

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Turkanis, S. A., and R. Karler. "Effects of delta-9-tetrahydrocannabinol, 11 -hydroxy-delta-9-tetrahydrocannabinol and cannabidiol on neuromuscular transmission in the frog." Neuropharmacology 25, no. 11 (1986): 1273–78. http://dx.doi.org/10.1016/0028-3908(86)90147-4.

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Manno, J. E., B. R. Manno, P. M. Kemp, et al. "Temporal Indication of Marijuana Use Can Be Estimated From Plasma and Urine Concentrations of 9-Tetrahydrocannabinol, 11-Hydroxy- 9-Tetrahydrocannabinol, and 11-Nor- 9-Tetrahydrocannabinol-9-Carboxylic Acid." Journal of Analytical Toxicology 25, no. 7 (2001): 538–49. http://dx.doi.org/10.1093/jat/25.7.538.

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Holland, Michael G., David M. Schwope, Robert Stoppacher, Shane B. Gillen та Marilyn A. Huestis. "Postmortem redistribution of Δ9-tetrahydrocannabinol (THC), 11-hydroxy-THC (11-OH-THC), and 11-nor-9-carboxy-THC (THCCOOH)". Forensic Science International 212, № 1-3 (2011): 247–51. http://dx.doi.org/10.1016/j.forsciint.2011.06.028.

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Dissertations / Theses on the topic "11-hydroxy-tetrahydrocannabinol"

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Awasthi, Rakesh. "Application of modeling-based approaches to study the pharmacokinetics and pharmacodynamics of Delta-9-tetrahydrocannabinol (THC) and its active metabolite." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5410.

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The medical use of marijuana is increasing, yet little is known about the exposure-response relationships resulting in its psychoactive effects. Δ9-tetrahydrocannabinol (THC) and its active metabolite (11-hydroxy-THC; THC-OH) are the principal psychoactive components in marijuana. It is well known that the plasma concentrations of the psychoactive components of marijuana do not directly relate to the observed psychoactive effects. The presence of a counter-clockwise hysteresis in the plasma concentrations-effect plot demonstrates a temporal delay between the plasma concentrations and observed
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