Relevant bibliographies by topics / [11C]PBR28

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic '[11C]PBR28'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "[11C]PBR28"

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Datta, Gourab, Ines R. Violante, Gregory Scott, et al. "Translocator positron-emission tomography and magnetic resonance spectroscopic imaging of brain glial cell activation in multiple sclerosis." Multiple Sclerosis Journal 23, no. 11 (2016): 1469–78. http://dx.doi.org/10.1177/1352458516681504.

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Background: Multiple sclerosis (MS) is characterised by a diffuse inflammatory response mediated by microglia and astrocytes. Brain translocator protein (TSPO) positron-emission tomography (PET) and [myo-inositol] magnetic resonance spectroscopy (MRS) were used together to assess this. Objective: To explore the in vivo relationships between MRS and PET [11C]PBR28 in MS over a range of brain inflammatory burden. Methods: A total of 23 patients were studied. TSPO PET imaging with [11C]PBR28, single voxel MRS and conventional magnetic resonance imaging (MRI) sequences were undertaken. Disability
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Herranz, Elena, Céline Louapre, Constantina Andrada Treaba, et al. "Profiles of cortical inflammation in multiple sclerosis by 11C-PBR28 MR-PET and 7 Tesla imaging." Multiple Sclerosis Journal 26, no. 12 (2019): 1497–509. http://dx.doi.org/10.1177/1352458519867320.

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Background: Neuroinflammation with microglia activation is thought to be closely related to cortical multiple sclerosis (MS) lesion pathogenesis. Objective: Using 11C-PBR28 and 7 Tesla (7T) imaging, we assessed in 9 relapsing–remitting multiple sclerosis (RRMS) and 10 secondary progressive multiple sclerosis (SPMS) patients the following: (1) microglia activation in lesioned and normal-appearing cortex, (2) cortical lesion inflammatory profiles, and (3) the relationship between neuroinflammation and cortical integrity. Methods: Mean 11C-PBR28 uptake was measured in focal cortical lesions, cort
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Toppala, Sini, Laura L. Ekblad, Jouni Tuisku та ін. "Association of Early β-Amyloid Accumulation and Neuroinflammation Measured With [11C]PBR28 in Elderly Individuals Without Dementia". Neurology 96, № 12 (2021): e1608-e1619. http://dx.doi.org/10.1212/wnl.0000000000011612.

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ObjectiveTo examine whether early β–amyloid (Aβ) accumulation and metabolic risk factors are associated with neuroinflammation in elderly individuals without dementia.MethodsWe examined 54 volunteers (mean age 70.0 years, 56% women, 51% APOE ɛ4 carriers) with the translocator protein (TSPO) tracer [11C]PBR28 to assess neuroinflammation and with [11C] Pittsburgh compound B (PiB) to assess cerebral Aβ accumulation. [11C]PBR28 and [11C]PiB standardized uptake value ratios (SUVRs) were quantified in 6 regions of interests by using the cerebellar cortex as a pseudo-reference and reference region, r
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Tran, Thuy T., Jean-Dominique Gallezot, Lucia B. Jilaveanu, et al. "[11C]Methionine and [11C]PBR28 as PET Imaging Tracers to Differentiate Metastatic Tumor Recurrence or Radiation Necrosis." Molecular Imaging 19 (January 1, 2020): 153601212096866. http://dx.doi.org/10.1177/1536012120968669.

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Purpose: As stereotactic radiosurgery (SRS) and immunotherapy are increasingly used to treat brain metastases, incidence of radiation necrosis (RN) is consequently rising. Differentiating tumor regrowth (TR) from RN is vital in management but difficult to assess using MRI. We hypothesized that tumor methionine levels would be elevated given increased metabolism and high amino acid uptake, whereas RN would increase inflammation marked by upregulated translocator protein (PBR-TSPO), which can be quantified with specific PET tracers. Procedures: We performed a feasibility study to prospectively e
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Owen, David R., Owain W. Howell, Sac-Pham Tang, et al. "Two Binding Sites for [3H]PBR28 in Human Brain: Implications for TSPO PET Imaging of Neuroinflammation." Journal of Cerebral Blood Flow & Metabolism 30, no. 9 (2010): 1608–18. http://dx.doi.org/10.1038/jcbfm.2010.63.

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[11C]PBR28, a radioligand targeting the translocator protein (TSPO), does not produce a specific binding signal in approximately 14% of healthy volunteers. This phenomenon has not been reported for [11C]PK11195, another TSPO radioligand. We measured the specific binding signals with [3H]PK11195 and [3H]PBR28 in brain tissue from 22 donors. Overall, 23% of the samples did not generate a visually detectable specific autoradiographic signal with [3H]PBR28, although all samples showed [3H]PK11195 binding. There was a marked reduction in the affinity of [3H]PBR28 for TSPO in samples with no visible
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Sandiego, Christine M., Jean-Dominique Gallezot, Brian Pittman, et al. "Imaging robust microglial activation after lipopolysaccharide administration in humans with PET." Proceedings of the National Academy of Sciences 112, no. 40 (2015): 12468–73. http://dx.doi.org/10.1073/pnas.1511003112.

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Neuroinflammation is associated with a broad spectrum of neurodegenerative and psychiatric diseases. The core process in neuroinflammation is activation of microglia, the innate immune cells of the brain. We measured the neuroinflammatory response produced by a systemic administration of the Escherichia coli lipopolysaccharide (LPS; also called endotoxin) in humans with the positron emission tomography (PET) radiotracer [11C]PBR28, which binds to translocator protein, a molecular marker that is up-regulated by microglial activation. In addition, inflammatory cytokines in serum and sickness beh
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Sari, Hasan, Riccardo Galbusera, Guillaume Bonnier, et al. "Multimodal Investigation of Neuroinflammation in Aviremic Patients With HIV on Antiretroviral Therapy and HIV Elite Controllers." Neurology - Neuroimmunology Neuroinflammation 9, no. 2 (2022): e1144. http://dx.doi.org/10.1212/nxi.0000000000001144.

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Background and ObjectivesThe presence of HIV in the CNS has been related to chronic immune activation and cognitive dysfunction. The aim of this work was to investigate (1) the presence of neuroinflammation in aviremic people with HIV (PWH) on therapy and in nontreated aviremic PWH (elite controllers [ECs]) using a translocator protein 18 kDa radioligand; (2) the relationship between neuroinflammation and cognitive function in aviremic PWH; and (3) the relationship between [11C]-PBR28 signal and quantitative MRI (qMRI) measures of brain tissue integrity such as T1 and T2 relaxation times (rts)
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Femminella, Grazia Daniela, Melanie Dani, Melanie Wood, et al. "Microglial activation in early Alzheimer trajectory is associated with higher gray matter volume." Neurology 92, no. 12 (2019): e1331-e1343. http://dx.doi.org/10.1212/wnl.0000000000007133.

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ObjectiveTo investigate the influence of microglial activation in the early stages of Alzheimer's disease trajectory, we assessed the relationship between microglial activation and gray matter volume and hippocampal volume in patients with mild cognitive impairment (MCI).MethodsIn this study, 55 participants (37 with early stages of MCI and 18 controls) underwent [11C]PBR28 PET, a marker of microglial activation; volumetric MRI to evaluate gray matter and hippocampal volumes as well as clinical and neuropsychometric evaluation. [11C]PBR28 VT(volume of distribution) was calculated using arteria
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Rizzo, Gaia, Mattia Veronese, Matteo Tonietto, Paolo Zanotti-Fregonara, Federico E. Turkheimer, and Alessandra Bertoldo. "Kinetic Modeling without Accounting for the Vascular Component Impairs the Quantification of [11C]PBR28 Brain PET Data." Journal of Cerebral Blood Flow & Metabolism 34, no. 6 (2014): 1060–69. http://dx.doi.org/10.1038/jcbfm.2014.55.

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The positron emission tomography radioligand [11C]PBR28 targets translocator protein (18 kDa) (TSPO) and is a potential marker of neuroinflammation. [11C]PBR28 binding is commonly quantified using a two-tissue compartment model and an arterial input function. Previous studies with [11C]HRJ-PK11195 demonstrated a slow irreversible binding component to the TSPO proteins localized in the endothelium of brain vessels, such as venous sinuses and arteries. However, the impact of this component on the quantification of [11C]PBR28 data has never been investigated. In this work we propose a novel kinet
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Rizzo, Gaia, Mattia Veronese, Matteo Tonietto, et al. "Generalization of endothelial modelling of TSPO PET imaging: Considerations on tracer affinities." Journal of Cerebral Blood Flow & Metabolism 39, no. 5 (2017): 874–85. http://dx.doi.org/10.1177/0271678x17742004.

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The 18 kDa translocator protein (TSPO) is a marker of microglia activation and the main target of positron emission tomography (PET) ligands for neuroinflammation. Previous works showed that accounting for TSPO endothelial binding improves PET quantification for [11C]PBR28, [18F]DPA714 and [11C]-R-PK11195. It is still unclear, however, whether the vascular signal is tracer-dependent. This work aims to explore the relationship between the TSPO vascular and tissue components for PET tracers with varying affinity, also assessing the impact of affinity towards the differentiability amongst kinetic
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Dissertations / Theses on the topic "[11C]PBR28"

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BARLETTA, VALERIA TERESA. "In vivo analyses of the correlates of cortical and white matter pathology in patients with multiple sclerosis by quantitative 7 Tesla and 3 Tesla MRI and molecular imaging." Doctoral thesis, 2021. http://hdl.handle.net/11573/1546445.

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This thesis is divided in two sections. The first reports the results from a project regarding the application of ultra-high-field quantitative MRI for the study of cortical grey matter pathology in patients with early multiple sclerosis (MS). Applying a Combined Myelin Estimation method, obtained by 7 Tesla magnetic resonance imaging, we aimed at characterizing cortical microstructural abnormalities related to myelin content in cortical lesions and normal-appearing cortex, to assess their evolution at 1-year follow-up and to relate cortical myelin changes to clinical and radiological disease
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Book chapters on the topic "[11C]PBR28"

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Zheng, Qi-Huang, Min Wang, and Bruce H. Mock. "Synthesis ofN-(2-[11C]Methoxybenzyl)-N-(4-Phenoxypyridin-3-yl)Acetamide ([11C]PBR28)." In Radiochemical Syntheses. John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118140345.ch30.

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Donat, Cornelius K., Nazanin Mirzaei, Sac-Pham Tang, Paul Edison, and Magdalena Sastre. "Imaging of Microglial Activation in Alzheimer’s Disease by [11C]PBR28 PET." In Biomarkers for Alzheimer’s Disease Drug Development. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7704-8_22.

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Donat, Cornelius K., Nazanin Mirzaei, Sac-Pham Tang, Paul Edison, and Magdalena Sastre. "Erratum to: Imaging of Microglial Activation in Alzheimer’s Disease by [11C]PBR28 PET." In Biomarkers for Alzheimer’s Disease Drug Development. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7704-8_26.

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Kim, Sungeun, Kwangsik Nho, Shannon L. Risacher, et al. "PARP1 Gene Variation and Microglial Activity on [11C]PBR28 PET in Older Adults at Risk for Alzheimer’s Disease." In Multimodal Brain Image Analysis. Springer International Publishing, 2013. http://dx.doi.org/10.1007/978-3-319-02126-3_15.

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Conference papers on the topic "[11C]PBR28"

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Mabrouk, Rostom. "A Model to Explain 11C-PBR28 SUV Profile in Parkinson’s disease and Unaffected Lrrk2 Mutation Carriers." In 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). IEEE, 2017. http://dx.doi.org/10.1109/nssmic.2017.8533118.

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Journal articles
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