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Journal articles on the topic '[11C]TMSX'

Author: Grafiati
Published: 2 June 2025
Last updated: 31 July 2025

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1

Rissanen, Eero, Jouni Tuisku, Pauliina Luoto, et al. "Automated Reference Region Extraction and Population-Based Input Function for Brain [11C]TMSX PET Image Analyses." Journal of Cerebral Blood Flow & Metabolism 35, no. 1 (2014): 157–65. http://dx.doi.org/10.1038/jcbfm.2014.194.

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[11C]TMSX ([7- N-methyl-11C]-(E)-8-(3,4,5-trimethoxystyryl)-1,3,7-trimethylxanthine) is a selective adenosine A2A receptor (A2AR) radioligand. In the central nervous system (CNS), A2AR are linked to dopamine D2 receptor function in striatum, but they are also important modulators of inflammation. The golden standard for kinetic modeling of brain [11C]TMSX positron emission tomography (PET) is to obtain arterial input function via arterial blood sampling. However, this method is laborious, prone to errors and unpleasant for study subjects. The aim of this work was to evaluate alternative input
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2

Kawamura, Kazunori, and Kiichi Ishiwata. "Improved synthesis of [11C]SA4503, [11C]MPDX and [11C]TMSX by use of [11C]methyl triflate." Annals of Nuclear Medicine 18, no. 2 (2004): 165–68. http://dx.doi.org/10.1007/bf02985109.

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3

Rissanen, Eero, Jere R. Virta, Teemu Paavilainen, et al. "Adenosine A2A Receptors in Secondary Progressive Multiple Sclerosis: A [11C]TMSX Brain PET Study." Journal of Cerebral Blood Flow & Metabolism 33, no. 9 (2013): 1394–401. http://dx.doi.org/10.1038/jcbfm.2013.85.

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In this study, positron emission tomography (PET) imaging with a radioligand to adenosine A2A receptors (A2AR)—a potent regulator of inflammation—was used to gain insight into the molecular alterations in normal-appearing white matter (NAWM) and gray matter (GM) in secondary progressive multiple sclerosis (SPMS). Normal-appearing white matter and GM, despite seeming normal in conventional mangnetic resonance imaging (MRI), are important loci of widespread inflammation, neuronal damage, and source of progressive disability in multiple sclerosis (MS). Dynamic PET imaging using A2AR-specific [ 11
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4

Rissanen, Eero, Jouni Tuisku, Pauliina Luoto, et al. "Automated reference region extraction and population-based input function for brain [(11)C]TMSX PET image analyses." J Cereb Blood Flow Metab 35, no. 1 (2014): 157–65. https://doi.org/10.1038/jcbfm.2014.194.

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[(11)C]TMSX ([7-N-methyl-(11)C]-(E)-8-(3,4,5-trimethoxystyryl)-1,3,7-trimethylxanthine) is a selective adenosine A2A receptor (A2AR) radioligand. In the central nervous system (CNS), A2AR are linked to dopamine D2 receptor function in striatum, but they are also important modulators of inflammation. The golden standard for kinetic modeling of brain [(11)C]TMSX positron emission tomography (PET) is to obtain arterial input function via arterial blood sampling. However, this method is laborious, prone to errors and unpleasant for study subjects. The aim of this work was to evaluate alternative i
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5

Ishiwata, Kiichi, Wei-Fang Wang, Yuichi Kimura, Kazunori Kawamura, and Kenji Ishii. "Preclinical studies on [11C]TMSX for mapping adenosine A2A receptors by positron emission tomography." Annals of Nuclear Medicine 17, no. 3 (2003): 205–11. http://dx.doi.org/10.1007/bf02990023.

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6

Mishina, Masahiro, Kiichi Ishiwata, Mika Naganawa, et al. "Adenosine A2A Receptors Measured with [11C]TMSX PET in the Striata of Parkinson's Disease Patients." PLoS ONE 6, no. 2 (2011): e17338. http://dx.doi.org/10.1371/journal.pone.0017338.

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7

Naganawa, Mika, Yuichi Kimura, Masahiro Mishina, et al. "Quantification of adenosine A2A receptors in the human brain using [11C]TMSX and positron emission tomography." European Journal of Nuclear Medicine and Molecular Imaging 34, no. 5 (2006): 679–87. http://dx.doi.org/10.1007/s00259-006-0294-0.

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8

Mishina, Masahiro, Kiichi Ishiwata, Yuichi Kimura, et al. "Evaluation of distribution of adenosine A2A receptors in normal human brain measured with [11C]TMSX PET." Synapse 61, no. 9 (2007): 778–84. http://dx.doi.org/10.1002/syn.20423.

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9

Ishiwata, Kiichi, Masahiro Mishina, Yuichi Kimura, Keiichi Oda, Toru Sasaki, and Kenji Ishii. "First visualization of adenosine A2A receptors in the human brain by positron emission tomography with [11C]TMSX." Synapse 55, no. 2 (2004): 133–36. http://dx.doi.org/10.1002/syn.20099.

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10

Ishiwata, Kiichi, Masaki Mizuno, Yuichi Kimura, et al. "Potential of [11C]TMSX for the evaluation of adenosine A2A receptors in the skeletal muscle by positron emission tomography." Nuclear Medicine and Biology 31, no. 7 (2004): 949–56. http://dx.doi.org/10.1016/j.nucmedbio.2004.06.003.

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11

Mizuno, Masaki, Yuichi Kimura, Ken Tokizawa, et al. "Greater adenosine A2A receptor densities in cardiac and skeletal muscle in endurance-trained men: a [11C]TMSX PET study." Nuclear Medicine and Biology 32, no. 8 (2005): 831–36. http://dx.doi.org/10.1016/j.nucmedbio.2005.07.003.

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12

Ishiwata, Kiichi, Kazunori Kawamura, Yuichi Kimura, Keiichi Oda, and Kenji Ishii. "Potential of an adenosine A2A receptor antagonist [11C]TMSX for myocardial imaging by positron emission tomography: a first human study." Annals of Nuclear Medicine 17, no. 6 (2003): 457–62. http://dx.doi.org/10.1007/bf03006434.

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13

Lahesmaa, Minna, Vesa Oikonen, Semi Helin, et al. "Regulation of human brown adipose tissue by adenosine and A2A receptors – studies with [15O]H2O and [11C]TMSX PET/CT." European Journal of Nuclear Medicine and Molecular Imaging 46, no. 3 (2018): 743–50. http://dx.doi.org/10.1007/s00259-018-4120-2.

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14

Ishiwata, Kiichi, Hideo Tsukada, Yuichi Kimura, Kazunori Kawamura, Norihiro Harada, and Harry H. Hendrikse. "In vivo evaluation of [11C]TMSX and [11C]KF21213 for mapping adenosine A2A receptors: Brain kinetics in the conscious monkey and P-glycoprotein modulation in the mouse brain." Journal of Cerebral Blood Flow & Metabolism 25, no. 1_suppl (2005): S658. http://dx.doi.org/10.1038/sj.jcbfm.9591524.0658.

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15

Lahesmaa, Minna, Vesa Oikonen, Semi Helin, et al. "Correction to: Regulation of human brown adipose tissue by adenosine and A2A receptors – studies with [15O]H2O and [11C]TMSX PET/CT." European Journal of Nuclear Medicine and Molecular Imaging 45, no. 12 (2018): 2244. http://dx.doi.org/10.1007/s00259-018-4144-7.

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16

Waggan, Imran, Eero Rissanen, Jouni Tuisku, et al. "Adenosine A2A receptor availability in patients with early- and moderate-stage Parkinson’s disease." Journal of Neurology, September 2, 2022. http://dx.doi.org/10.1007/s00415-022-11342-1.

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Abstract Introduction Adenosine 2A (A2A) receptors co-localize with dopamine D2 receptors in striatopallidal medium spiny neurons of the indirect pathway. A2A receptor activation in the striatum or pallidum decreases D2 signaling. In contrast, A2A receptor antagonism may help potentiate it. Furthermore, previous PET studies have shown increased A2A receptor availability in striatum of late-stage PD patients with dyskinesia. However, human in vivo evidence for striatal A2A receptor availability in early-stage PD is limited. This study aimed to investigate possible differences in A2A receptor av
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17

Naganawa, Mika, Masahiro Mishina, Muneyuki Sakata, et al. "Test-retest variability of adenosine A2A binding in the human brain with 11C-TMSX and PET." EJNMMI Research 4, no. 1 (2014). http://dx.doi.org/10.1186/s13550-014-0076-9.

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