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Relevant bibliographies by topics / 123I-CLINDE SPECT

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Academic literature on the topic '123I-CLINDE SPECT'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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Journal articles on the topic "123I-CLINDE SPECT"

1

Feng, Ling, Claus Svarer, Gerda Thomsen, et al. "In vivo quantification of cerebral translocator protein binding in humans using 6-chloro-2-(4'-123I-iodophenyl)-3-(N,N-diethyl)-imidazo[1,2-a]pyridine-3-acetamide SPECT." J Nucl Med. 55, no. 12 (2014): 1966–72. https://doi.org/10.2967/jnumed.114.143727.

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This study provides the first comprehensive quantification of translocator protein (TSPO) binding using SPECT and 6-chloro-2-(4'-(123)I-iodophenyl)-3-(N,N-diethyl)-imidazo[1,2-a]pyridine-3-acetamide ((123)I-CLINDE) in neurologic patients. (123)I-CLINDE is structurally related to well-known PET ligands such as (18)F-PBR111 and (18)F-DPA-714. METHODS: Six patients with cerebral stroke and 4 patients with glioblastoma multiforme (GBM) underwent 150-min dynamic SPECT scans with arterial blood sampling. Four of the patients were rescanned. All patients were genotyped for the rs6971 polymor

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2

Feng, Ling, Per Jensen, Gerda Thomsen, et al. "The Variability of Translocator Protein Signal in Brain and Blood of Genotyped Healthy Humans using in vivo [123I]CLINDE-SPECT imaging – a test-retest study." Journal of Nuclear Medecine 58, no. 6 (2016): 989–95. https://doi.org/10.2967/jnumed.116.183202.

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<sup>123</sup>I-CLINDE is a radiotracer developed for single photon emission computed tomography (SPECT) and targets the 18 kDa Translocator protein (TSPO). TSPO is upregulated in glial cells and used as a measure of neuroinflammation in a variety of CNS diseases. The aim of this study was to examine the test-retest variability of <sup>123</sup>I-CLINDE binding in healthy subjects.<strong> </strong> <strong>Methods</strong> SPECT-scans were acquired over 90 mins in sixteen healthy controls (nine females, eight mixed affinity binder (MAB) and eight high affinity binders (HAB) twice with an inte

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3

Jensen, P., L. Feng, I. Law, et al. "TSPO Imaging in Glioblastoma Multiforme: A Direct Comparison Between 123I-CLINDE SPECT, 18F-FET PET, and Gadolinium-Enhanced MR Imaging." Journal of Nuclear Medicine 56, no. 9 (2015): 1386–90. http://dx.doi.org/10.2967/jnumed.115.158998.

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4

Mattner, Filomena, David Linares Bandin, Maria Staykova, et al. "Evaluation of [123I]-CLINDE as a potent SPECT radiotracer to assess the degree of astroglia activation in cuprizone-induced neuroinflammation." European Journal of Nuclear Medicine and Molecular Imaging 38, no. 8 (2011): 1516–28. http://dx.doi.org/10.1007/s00259-011-1784-2.

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5

Ohshima, Makiko, Tetsuaki Moriguchi, Jun-ichiro Enmi, et al. "[123I]CLINDE SPECT as a neuroinflammation imaging approach in a rat model of stroke." Experimental Neurology, May 2024, 114843. http://dx.doi.org/10.1016/j.expneurol.2024.114843.

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6

Jensen, Per, Brice Ozenne, Per Meden, et al. "Poststroke Translocator Protein Expression Dynamics and Correlations to Chronic Infarction: A ^[123I]‐CLINDE‐SPECT Study." Journal of Neuroimaging 35, no. 1 (2025). https://doi.org/10.1111/jon.70002.

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ABSTRACTBackground and PurposeThis study aims to investigate the longitudinal changes in translocator protein (TSPO) following stroke in different brain regions and potential associations with chronic brain infarction.MethodsTwelve patients underwent SPECT using the TSPO tracer 6‐Chloro‐2‐(4ʹ‐123I‐Iodophenyl)‐3‐(N,N‐Diethyl)‐Imidazo[1,2‐a]Pyridine‐3‐Acetamide, as well as structural MRI, at 10, 41, and 128 days (median) after ischemic infarction in the middle cerebral artery. TSPO expression was measured in lesional (MRI lesion and SPECT lesion), connected (pons and ipsilesional thalamus), and

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Conference papers on the topic "123I-CLINDE SPECT"

1

Auer, Benjamin, Kesava S. Kalluri, Aly H. Abayazeed, et al. "Aperture size selection for improved brain tumor detection and quantification in multi-pinhole 123I-CLINDE SPECT imaging." In 2020 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC). IEEE, 2020. http://dx.doi.org/10.1109/nss/mic42677.2020.9508019.

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