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1
Shen, Hua. "Responses Of paraoxonase 1 to dioxin-like pcb 126 ( 3,3',4,4',5-pentachlorobiphenyl): mechanisms and consequences." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/2770.
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Polychlorinated biphenyls (PCBs) are ubiquitous environmental pollutants that have been associated with various adverse health effects in humans and wildlife. Dioxin-like PCBs elicit a broad spectrum of biochemical and toxic changes including cardiovascular disorders. Paraoxonase 1 (PON1), an antioxidant enzyme, prevents oxidative stress and plays key roles in the pathogenesis of atherosclerosis. The overall goal of this dissertation is to investigate the mechanism and role of PON1 in the antioxidant defense to the exposure of 3, 3', 4, 4', 5-pentachlorobiphenyl (PCB 126), the most potent congener in PCB family. My overall hypothesis is that: The up-regulation of PON1 is an antioxidant response to PCB 126 exposure, which involves the Ah receptor (AhR) and results in changes in the PON1 protein level and activity which in turn has an influence on the oxidative stress status. First, the responses of PON1 gene expression and activities in serum and liver upon the PCB126 treatment were evaluated in the rat model. I found that PCB 126 up-regulated PON1, gene expression and activities, in a time and dose dependent manner. Next, I investigated the molecular mechanism of this response. My results show that the up-regulation of PON1 by PCB 126 involves the AhR and the XRE-like sequence in the gene promoter region. The up-regulation of PON1 was tissue specific, and this response probably protected liver and serum from lipid oxidation to some extent. The structure-activity relationship studies with PCB congeners indicate that the up-regulation of PON1 was specific to dioxin-like PCB 126. Other different AhR ligands displayed different PON1 induction capabilities. Also, reduction of PON1 activity was found in male rats dosed with non-dioxin-like PCBs. Finally I investigated the interaction, and possible protection, of other antioxidants (Se and NAC) on the response to PCB 126. I found that these antioxidants reduced the magnitude of the response of PON1 to the PCB 126 exposure in liver. Both the increase of PON1 activities and addition of antioxidants may be the reason for the lack in increase of lipid peroxidation. In total, these findings support my hypothesis and suggest that up-regulation of PON1 by PCB 126 may be an adaptive antioxidant mechanism that is involved in the body's antioxidant system.
2
Hatzinger, Reinhold, and Walter Katzenbeisser. "Log-linear Rasch-type models for repeated categorical data with a psychobiological application." Department of Statistics and Mathematics, WU Vienna University of Economics and Business, 2008. http://epub.wu.ac.at/126/1/document.pdf.
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The purpose of this paper is to generalize regression models for repeated categorical data based on maximizing a conditional likelihood. Some existing methods, such as those proposed by Duncan (1985), Fischer (1989), and Agresti (1993, and 1997) are special cases of this latent variable approach, used to account for dependencies in clustered observations. The generalization concerns the incorporation of rather general data structures such as subject-specific time-dependent covariates, a variable number of observations per subject and time periods of arbitrary length in order to evaluate treatment effects on a categorical response variable via a linear parameterization. The response may be polytomous, ordinal or dichotomous. The main tool is the log-linear representation of appropriately parameterized Rasch-type models, which can be fitted using standard software, e.g., R. The proposed method is applied to data from a psychiatric study on the evaluation of psychobiological variables in the therapy of depression. The effects of plasma levels of the antidepressant drug Clomipramine and neuroendocrinological variables on the presence or absence of anxiety symptoms in 45 female patients are analyzed. The individual measurements of the time dependent variables were recorded on 2 to 11 occasions. The findings show that certain combinations of the variables investigated are favorable for the treatment outcome. (author´s abstract)<br>Series: Research Report Series / Department of Statistics and Mathematics
3
Eichholz, Gerda Langmantel. "Aprendizagens da lei 11.645/08 na experiência intercultural dos XII Jogos dos Povos Indígenas em Cuiabá-MT." Universidade Federal de Mato Grosso, 2015. http://ri.ufmt.br/handle/1/126.
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Previous issue date: 2015-04-28<br>CNPq<br>A presente dissertação discute as aprendizagens sobre a Lei 11.645/08 na experiência
intercultural que ocorreu durante a realização dos XII Jogos dos Povos Indígenas (XII
JPI) realizados em Cuiabá-MT, tendo como base a formação dos professores na
perceptiva da educação intercultural que visou preparar professores e alunos das escolas
públicas do município para o encontro com o Outro, o indígena. O objetivo da pesquisa
foi compreender como se estabeleceram as relações entre os saberes e fazeres dos
professores e os saberes e fazeres que, numa perspectiva intercultural, é evidenciada a
partir dos alunos, podem qualificar a prática pedagógica na perspectiva da inclusão das
histórias e culturas dos povos indígenas na escola. Para tal, a pesquisadora participou
desde o processo de elaboração e execução do curso de formação, do acompanhamento
aos projetos pedagógicos dos professores que participam do curso ofertado pela UFMT,
até a organização e acompanhamento aos alunos com seus professores, aos Jogos dos
Povos Indígenas. A investigação teve por base a pesquisa-ação de abordagem qualitativa,
que utilizou como instrumentos: o questionário, caderno de campo e a filmagem. Nessa
pesquisa qualitativa, os conflitos entre a concepção colonialista e a pós-colonialista se
evidencia, trazendo a tona tanto os conflitos vivenciados como migrante em terras
indígenas, quanto como professora que se defronta com os preconceitos aos indígenas nas
escolas da cidade. A dinâmica da pesquisa e da pesquisadora se fundem e levam ao
aprofundamento dos referenciais que fundamentam os conflitos etnicoraciais e
etnicoculturais em Mato Grosso, cujo conflito de terra se dá pela ganancia do agronegócio
e colonização permanente com a defesa do direito dos povos nativos manterem-se nos
territórios tradicionais de seus ancestrais, do qual dependem as novas gerações para
perpetuarem suas formas de viver coletivo e em equilíbrio no ecossistema que os alimenta
em todas as dimensões da vida. A história do colonizador está registrada na produção
historiográfica, bem como nas publicações didáticas e paradidáticas dirigidas às crianças
e que contribuem para negar o caráter multiétnico e pluricultural da nação brasileira. A
implementação da Lei 11.645/08 se faz necessária, porém diante da cultura hegemônica
que se coloca em oposição aos processos de reconhecimento e respeito à diversidade, a
Lei não foi ainda implementada nas escolas de Cuiabá. Os dados obtidos no processo de
formação e intervenção pedagógica foram analisados qualitativamente e descritos numa
proposição interpretativa e reflexiva da práxis pedagógica, considerando-se que uma
concepção pedagógica e curricular que respeita e valoriza a diversidade cultural exige
olhar a escola de forma diferenciada, isto é, vê-la enquanto espaço cultural e social, em
que se manifestam diversas e várias maneiras de se relacionar, de se comunicar e de agir
e de pensar. Os discursos dos alunos e professores foram articulados aos fundamentos
teóricos de cultura, alteridade, diversidade cultural, identidade, interculturalidade e
corporeidade, com o objetivo de se compreender o processo de desconstrução de
estereótipos e preconceitos construídos e perpetuados no imaginário popular em relação
aos povos indígenas. Com a pesquisa, aprofundam-se as discussões sobre a
implementação da Lei 11.645/08, difundindo ideias reflexivas sobre a formação inicial,
continuada e à prática docente, a fim de humanizar as relações sociais que permeiam o
espaço da escola que busca educar para a convivência na diversidade, pautada em
conhecimentos fomentados no respeito aos indígenas brasileiros.<br>This dissertation discusses the learning on Law 11.645/08 and the cultural experience that
took place during the XII Indigenous People Games (XII JPI in Portuguese) in Cuiabá-
MT, based on teachers' formation on intercultural education perspective, which aimed to
prepare teachers and students from public schools at the municipality, to the meeting with
the Other, the indigenous. The objective of the research was to understand how the
relationships between teachers' knowledges and practices were established, and the
knowledges and practices that, in an intelectual perspective, is made clear from students,
who can qualify the pedagogical practice on the perspective of inclusion of histories and
cultures of indigenous people in the school. To do so, the researcher has participated since
the elaboration and execution process of the formation course, the follow-up to the
teachers' pedagogical projects who participate in the course offered by UFMT, to the
organization and follow-up of students with their teachers, to the Indigenous People
Games. Investigation was based on action research on a qualitative approach, which used
as instruments: a questionnaire, field notes and filming. On this qualitative research, the
conflicts between the colonialist and postcolonialist conception show up, bringing the
conflicts as a migrant in indigenous land, as well as a teacher who faces the prejudice to
the indigenous people in the city schools. The research dynamics, and the researcher's,
merge and lead to the deepening of the referentils that base the ethnical-ratial and
ethnical-cultural conflicts in Mato Grosso, whose land conflict happens due to the greed
of agrobusiness and the permanent colonisation with the defense of native people's rights
to remain on their ancestors' traditional territories, which the new generations depend on,
to perpetuate their colective lifestyle and in balance with the environment that feeds them
in all dimensions of life. The colonizer's life is registered on historiographical production,
as well as didactic and paradidactic publications driven to children and that contribute to
deny the multiethnical, pluricultural character of Brazilian population. The passing of
Law 11.645/08 is necessary, however, facing the hegemonic culture that takes place
against the recognition and diversity respect processes, the Law hasn't been applied in
Cuiabá schools yet. Data obtained on formation and pedagogical intervention process
were qualitatively analysed and described in an interpretative, reflexive proposition of
pedagogical praxis, considering that a pedagogical and curricular conception that respects
and values cultural diversity demands to look at the school in a diferent way, i.e., to look
at it as a cultural, social space, where several ways to relate, to communicate and to act
and to think. Students' and teachers' discourse were articulated to the theoretic fundaments
of culture, alterity, cultural diversity, identity, interculturality and corporeity, with the
goal to understand the deconstruction process of stereotypes and prejudices built and
perpetuated in people's imagination, regarding indigenous people. With the research, the
discussion on Law 11.645/08 deepen, spreading reflexive ideas on initial, continued
formation, and teacher formation, in order to humanize the social relationships which
permeate the school environment, which aims to educate for companionship on diversity,
ruled on knowledge encourage on the respect to the indigenous people.
4
Trenta, Cristina <1967>. "Iva e servizi di comunicazione nel modello comunitario e nell'esperienza italo-svedese." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2007. http://amsdottorato.unibo.it/126/1/iva_servizi_di_comunicazione.pdf.
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Il 17 maggio 1977 è entrata in vigore all'interno dell'Unione europea la Sesta
Direttiva del Consiglio 77/388/CEE, comunemente nota come Sesta Direttiva,
in “materia di armonizzazione delle legislazioni degli Stati Membri relative
alle imposte sulla cifra di affari - Sistema comune di imposta sul valore
aggiunto: base imponibile uniforme”. Agli Stati membri veniva richiesto di
modificare i loro sistemi IVA in accordo con le nuove regole delineate dalla
Direttiva.
La Sesta Direttiva, scritta negli anni Settanta, non conteneva alcuna
regolamentazione relativa ai servizi di comunicazione e telecomunicazione: nei
primi anni Novanta, con l'emergere della Società dell'Informazione, divenne
chiaro che questa mancanza cominciava a pesare negativamente sulla
competitività degli operatori europei.
Il 26 giugno 1999, al termine di un lungo processo, venne adottata la
Direttiva del Consiglio 1999/59/CE, che emendava la Direttiva 77/388/CEE per
quanto atteneva alla regolamentazione in materia di IVA applicabili ai servizi di
telecomunicazione .
Poi, il 15 maggio 2002 è entrata in vigore la Direttiva del Consiglio
2002/38/CE che ha introdotto sostanziali cambiamenti pro tempore alla
Direttiva 77/388/CEE, ampliando gli emendamenti introdotti dalla precedente
Direttiva 1999/59/EC, e stabilendo nuove regole in materia di servizi di
radiodiffusione e di televisione e a determinati servizi prestati tramite mezzi
elettronici.
La recente rifusione della Sesta Direttiva, 2006/112/CE del 29 novembre
2006 sul sistema IVA, non ha modificato il quadro legislativo comunitario in
materia di servizi di telecomunicazioni e servizi di radiodiffusione e di
televisione e di servizi prestati per via elettronica: la Direttiva del Consiglio
2006/138/CE, adottata il 19 dicembre 2006 a emendamento della
2006/112/CE, ha confermato che la regolamentazione IVA applicabile ai servizi
di comunicazione radio-televisivi e a certi servizi forniti per via elettronica
resteranno soggetti a questo regime fino al 31 dicembre 2008.
5
Futcha-Djaheu, Sandrine. "Extraction manuelles de primitives issues d'applications en télécommunication pour une plateforme monoprocesseur." Mémoire, École de technologie supérieure, 2008. http://espace.etsmtl.ca/126/1/FUTCHA%2DDJAHEU_Sandrine.pdf.
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L'implémentation d'algorithmes complexes sur des plateformes matérielles est un processus
long. De ce fait, il devient pertinent de vérifier au tout début de la conception, si une
platefonne donnée possède la capacité de traiter de nouveaux algorithmes. Ceci dans le
but de réduire les efforts de programmation liés à leur implémentation. Le temps d'exécution
d'une application ou son nombre de cycles, le taux d'utilisation de la mémoire et la
consommation de puissance sont de bons exemples de métriques dont la prédiction vaut
le peine. Le défi auquel cette dernière fait face s'accroît, d'autant plus que l'application
choisie exhibe une variabilité en termes de temps d'exécution.
Le but de ce projet de recherche est d'élaborer une méthodologie de prédiction du nombre
de cycles d'un algorithme de télécommunication quelconque sur des puces de traitement
de signal (DSP). L'approche globale qui est nôtre prend appui sur l'élaboration d'une
librairie. Cette approche tire profit de la richesse des librairies existentes comme celle
offerte par Matlab/Simulink® pour évaluer cette métrique. Comme Mafiab® est souvent
utilisé pour modéliser les systèmes de télécommunications et les valider, il a été choisi
pour ce projet. L'idée consiste à pré-caractériser les cellules fréquemment employées dans
ces librairies pour estimer le temps de calcul de l'unité centrale de traitement (CPU) à
partir des modèles Matlab®. De là, des équations générales de variabilité sont établies.
Celles-ci décrivent le comportement de la métrique d'intérêt dans le processeur à travers
l'étude de trois applications spécifiques.
Les applications visées sont le Zéro Forcing Sorted QR Décomposition (ZF-SQRD), le
récepteur Rake et la transformée rapide de Fourier (FFT). La première étape vers l'élaboration
des équations de prédiction consiste à décomposer ces applications en blocs
décrivant les opérations récurrentes opérées en télécommunication, nommées primitives
fonctionnelles. Ensuite s'établit un lien entre ces opérations et celles équivalentes du côté
matériel (primitives stmcturelles) pour compléter la librairie. Finalement, la validation des
équations du temps CPU déduites en se servant de la librairie couronne le travail par l'implémentation
dans un processeur. La précision des résultats repose sur la configuration des
options offertes par le compilateur, en particulier sur la sélection ou non du pipeline logiciel.
Lorsque ce dernier n'est pas sélectionné, les prédictions et les implémentations sont
similaires, bonifiant ainsi la librairie établie. La sélection du pipeline logiciel introduit un
rapport autour d'un pour deux entre les prédictions et les implémentations.
6
Catenacci, Volpi Nicola. "The modularity of attention from an artificial intelligence perspective." Thesis, IMT Alti Studi Lucca, 2013. http://e-theses.imtlucca.it/126/1/CatenacciVolpi_phdthesis.pdf.
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The development of agents with bounded rationality is still an important challenge of artificial intelligence. Indeed, when we are facing problems with a large number of states, if we do not reason about the computational resources of our agent, it is easy to encounter exponential
complexities or state explosions. One way to solve this problem is taking inspiration from the study of
attention in cognitive science. Attention can be considered as a filter in information processing that focuses only on relevant information, leaving out possibly all the useless computations. So to be focused only on a relevant subsets of the state space of a problem can be the
solution to increase the quality of our algorithms. Accordingly it is important to understand how to represent relevance and being able to compute automatically what is relevant in a given situation. In this thesis we link the study of attention with multi agent systems
(MAS). The introduced methodology starts finding a way to partition an input problem. Then it specializes the agents of a MAS on the partition’s subsets. Finally it finds a policy to switch the agents on or off according to the current context. This will be done allocating
computational resources to the agents during the task execution. Accordingly we will introduce two context aware methodologies based on Hopfield networks and dynamical neural fields to learn, store and recall online resource-allocation policies. This will lead to a dynamical characterization of such policies (i.e., attractors).
Finally the systems will be evaluated in distributed constraint optimization, classification and categorization tasks, underlining, when was possible, the cognitive plausibility of our proposals. Indeed the categorization task will be held in an active vision framework linking,
also experimentally, our proposals with the study of attention in animal and human vision.
7
COSTA, OSVALDO L. da. "Estudo e desenvolvimento de uma nova metodologia de produção de iodo-125 a partir de xenônio-124 pelo método de ativação neutrônica." reponame:Repositório Institucional do IPEN, 2015. http://repositorio.ipen.br:8080/xmlui/handle/123456789/25301.
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Submitted by Claudinei Pracidelli (cpracide@ipen.br) on 2015-12-10T17:38:32Z
No. of bitstreams: 0<br>Made available in DSpace on 2015-12-10T17:38:32Z (GMT). No. of bitstreams: 0<br>Tese (Doutorado em Tecnologia Nuclear)<br>IPEN/T<br>Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
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Ekstrand, Vilhelm. "Therapeutic applications of acoustic and electromagnetic energy /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-126-1/.
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Trunk, Alessa [Verfasser]. "Der Zuständigkeitswechsel nach § 126 Abs. 2 Satz 1 Strafprozessordnung. : Die prozessuale Überholung der Haftbeschwerde im Konflikt mit dem Beschleunigungsgrundsatz und dem Recht auf effektiven Rechtsschutz. / Alessa Trunk." Berlin : Duncker & Humblot, 2021. http://d-nb.info/1238493009/34.
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Romey, Kristin. "The Vogelbarke of Medinet Habu." [S.l. : s.n.], 2003. http://txspace.tamu.edu/bitstream/1969/126/1/etd-tamu-2003C-ANTH-Romey-1.pdf.
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Rivarola, José Luis. "Language in Society (Cambridge University Press), Volumen 5 (Números 1 y 2), 1976, pp. 1-128 y 129-255." Pontificia Universidad Católica del Perú, 2013. http://repositorio.pucp.edu.pe/index/handle/123456789/103603.
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Kölln, Raquel Suzane. "Caracterização nutricional e cinética da degradação ruminal da aveia branca IPR 126 ( Avena Sativa L. CV. IPR 126), sob diferentes níveis de adubação nitrogenada." Universidade Tecnológica Federal do Paraná, 2017. http://repositorio.utfpr.edu.br/jspui/handle/1/2482.
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CAPES; Fundação Araucária; CNPq<br>O objetivo do presente estudo foi estimar a composição bromatológicas e os parâmetros relativos à cinética de produção de gás in vitro da aveia IPR 126, adubada com diferentes níveis de nitrogênio (0, 60, 120, 240 kg há-1de N), em dois anos de produção (2013-2014).Foi determinada a composição química, sendo analisado: matéria seca (MS) matéria mineral (MM), proteína bruta (PB), extrato etéreo (EE), Fibra em Detergente Neutro (aFDNom), Fibra em Detergente Ácido (FDA), proteína insolúvel em detergente ácido (PIDA), lignina em detergente ácido (LDA),Carboidratos Totais (CT), Carboidratos Não Fibrosos (CNF) e Carboidratos Solúveis (CHOs) da cultivar IPR 126, assim como a estimativa dos parâmetros do modelo bicompartimental para cinética de produção de gases (Vf1, k1, Vf2 e k2 e L). A adubação nitrogenada influenciou apenas os teores de PB e CT em todos os níveis. Em relação às variáveis bromatológicas, LDA, CT, CNF e CHOs foram significativamente superiores em 2013. MM, aFDN e PB foram superiores em 2014. Em 2013, comparando os cortes realizados, a maioria das variáveis bromatológicas não apresentou diferença significativa, com exceção da LDA e CHOs. No ano de 2014, os valores observados das variáveis bromatológicas foram significativamente maiores no 1° corte para EE, CNF e CHOs. Para MM, aFDN, LDA e PIDA foram maiores no 2° corte. Houve efeito significativo em relação aos parâmetros da cinética de degradação produção de gás in vitro, com exceção da L. Na comparação dos anos de cultivo, k1, Vf2 e k2, apresentaram aumento no ano de 2014. No entanto, o Vf1 apresentou redução em 2014. No ano de 2013 comparando os cortes realizados, houve efeito significativo somente para as taxas k1 e k2. Não foram encontradas diferenças significativas em nenhum parâmetro, analisando os cortes de 2014. A aveia branca IPR 126 tem um bom potencial para ser cultivada na região sudoeste do Paraná, porque responde a adubação nitrogenada e consegue expressar seu potencial forrageiro mesmo com condições climáticas desfavoráveis. Os elevados teores de proteína bruta encontrados neste trabalho indicam um desequilíbrio entre as frações proteicas e energéticas, influenciando os parâmetros da cinética de degradação.<br>The objective of the present study was to estimate the bromatological composition and the parameters related to the in vitro gas production kinetics of oat IPR 126, fertilized with different nitrogen rates (0, 60, 120, 240 kg ha-1 of N), in two Years of production (2013- 2014). The chemical composition was determined: dry matter (DM), crude protein (PB), ethereal extract (EE), neutral detergent fiber (aFDNom), acid detergent fiber (FAD), insoluble protein (LDA), Total Carbohydrates (CT), Nonfibrous Carbohydrates (CNF) and Soluble Carbohydrates (CHOs) of cultivar IPR 126, as well as the estimation of the parameters of the bicompartmental model for kinetics of Production of gases (Vf1, k1, Vf2 e k2 e L). Nitrogen fertilization influenced only PB and CT contents. In relation to the bromatological variables, LDA, CT, CNF and CHOs were significantly higher in 2013. MM, aFDN and PB were higher in 2014. In 2013, comparing the performed cuts, most of the bromatological variables did not present a significant difference, except for LDA and CHOs. In the year 2014, the observed values of the bromatological variables were significantly higher in the 1st cut for EE, CNF and CHOs. For MM, aFDN, LDA and PIDA were higher in the 2nd cut. There was a significant effect in relation to the degradation kinetic parameters in vitro gas production, with the exception of L. In the comparison of the years of cultivation, k1, Vf2 and k2, increased in 2014. However, Vf1 presented a reduction in 2014. In the year of 2013 comparing the cuts performed, there was a significant effect only for rates k1 and k2. No significant differences were found in any parameter, analyzing the cuts of 2014. The white Oat IPR 126 has a good potential to be cultivated in the southwestern region of Paraná, because it responds to nitrogen fertilization and manages to express its forage potential even with unfavorable climatic conditions. The high levels of crude protein found in this work indicate an imbalance
between.
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Åhman, Elisabeth, and Fredrik Lundberg. "The effect of firm characteristics on disclosures: A Swedish context." Thesis, Uppsala universitet, Företagsekonomiska institutionen, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-258802.
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The aim of this thesis is to examine the quality of the disclosure IAS 1 Presentation of Financial Statements, paragraphs 122 and 125 in the annual reports of Swedish publicly listed firms. These paragraphs state that firms are required to disclose judgments made by management in preparing financial statements that may have significant impact on the recognized carrying amount. These paragraphs should also include information about major sources of estimation uncertainty. A quantitative research approach is used and the sample consists of 1,519 annual reports over a 7-year period. We construct a disclosure index to assess the quality of the disclosures in Critical judgements and key sources of estimation uncertainty (IAS 1:122 and 1:125) note and categorize the annual reports into four index groups. Additionally, the number of headlines in the note are counted and sorted into three other groups, creating a headline index. Lastly, we multiply the disclosure index with the headline index to get a score, which then enable us to distinguish and rank the quality of disclosure between firms. Further, we count the number of words in each individual disclosure in each annual report. This additional quantitative data enable regression analyses, further ensuring objectivity in assessing the disclosure quality. Agency theory and political cost theory are used as base for determining which firm characteristics may affect disclosure quality. We examine the firm characteristics firm visibility, ownership concentration and leverage to investigate any relationship with disclosure quality. We use the ordinary least squares (OLS) regression method to analyse this data. The analysis shows that firm visibility and leverage have positive relationships with disclosure quality. This supports the political cost theory and suggests that firms that are more visible have stronger incentives to attain a high disclosure quality. Our findings also support debt-associated agency problems and are also in line with prior studies that found a positive relationship between disclosure quality and the degree of leverage, which indicates that disclosures reduces the information gap.
14
Yu, Lai-yin, and 余麗賢. "MicroRNA-125 and FBI-1 in choriocarcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/206592.
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Choriocarcinoma is a malignant form of gestational trophoblastic disease arising from the trophoblastic epithelium. It is characterized by the presence of a mixed population of mononuclear cytotrophoblasts and multinucleated syncytotrophoblasts surrounded by hemorrhage and necrosis. Clinically, it is difficult to distinguish postmolar choriocarcinoma from an invasive mole. They also share similar histopathological features and are only distinguishable from invasive moles by the absence of chorionic villi. Since choriocarcinoma is an aggressive tumor with a high tendency to metastasize, it is better to have a definitive diagnosis to detect the disease at an earlier stage in order to tackle the problem before it becomes too advanced. It is thus necessary to investigate new potential markers which could help in making diagnosis at the early stage of the disease.
MicroRNAs are recognized as a new class of non-coding RNAs that regulate gene expressions post-transcriptionally through translational repression or degradation of the target messenger RNAs. They are involved in almost every biological process, including cell proliferation, differentiation as well as apoptosis. MiR-125 is one of the most widely investigated microRNAs in recent years, particularly in cancers. It is a highly conserved sequence that expresses ubiquitously in multiple human organs in a tissue-specific manner. The deregulation of miR-125 was commonly found in various types of cancers. Depending on the target messenger RNAs, miR-125 exerts either tumor suppressive or oncogenic effects. There are three homologues of miR-125, including miR-125a, miR-125b-1 and miR125b-2. Since all three homologues have very similar sequence and have the same seed region, they have common mRNA targets and similar functions but may express differentially in different tissues.
Factor that binds to inducer of short transcript-1(FBI-1) is a transcription factor that is involved in cell cycle arrest and terminal differentiation in different tissues. The deregulation of FBI-1 was associated with oncogenesis and the overexpression of FBI-1 was frequently demonstrated in multiple human cancers. However, the connection between miR-125 and FBI-1 in choriocarcinoma has not been reported. In this study, an inverse relationship between miR-125, including both miR-125a and miR-125b, and FBI-1 was demonstrated. Higher expression levels of miR-125a and miR-125b were demonstrated in the first-trimester extravillous trophoblasts,TEV-1, than in the JAR and JEG-3 choriocarcinoma cells, whereas the protein and mRNA expression levels of FBI-1 were significantly higher in JAR and JEG-3 cells than in TEV-1 cells.
Moreover, the overexpression of miR-125 down-regulated the FBI-1 expression level in both JAR and JEG-3 cells, suggesting that miR-125 may regulate FBI-1 through a direct interaction. By treating JEG-3 cells with a histone deacetylase inhibitor, trichostatin A (TSA), the expression levelsof miR-125a and miR-125b were up-regulated while the FBI-1 was down-regulated, suggesting the possible transcriptional silencing effect on miR-125 through histone deacetylation. Altogether, miR-125 affects FBI-1 expression and may serve as a new marker to differentiate malignant tumors from the benign GTD as well as a therapeutic target.<br>published_or_final_version<br>Pathology<br>Master<br>Master of Medical Sciences
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Brugaletta, Elisa. "Rotational evolution between 120 Myr and 1 Gyr." Doctoral thesis, Università di Catania, 2014. http://hdl.handle.net/10761/1554.
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In this work the rotational evolution and the lithium depletion of low -mass stars in young stellar system is investigated, taking advantage of extensive new data sets on rotational periods that have recently became available. The rotational evolution of slow-rotating stars between 100Myr and 1 Gyr have been examined in detail, outlining a complex behaviour that claim for improved modelling of the internal angular momentum transport and of the angular momentum loss via a magnetised wind. A puzzling change in the rotation distribution vs. mass takes place at 550 Myr, which seems to contradict current theoretical models. Previous assumptions on the factorisation of the rotational dependence on time and mass do not hold in the 100 Myr - 1 Gyr time interval, which complicates somewhat the age inference from rotation. Studies based on the distribution of rotational periods of solar-type stars suggest in addition a possible link between lithium depletion and the rotational history of stars. The dispersion of lithium abundance at a given color in the Pleiades member stars have been re-examined. Once removed the mass dependence from rotation and Li-depletion a soft correlation between lithium and rotational periods in K and M type stars has been found. On the other hand, a clear and solid correlation has been found in the 0.74<=(B-V)<1.15 color range. In this (B-V) range the slower a star is the larger is the lithium depletion. A comparison and an analysis of the rotation periods and lithium depletion in young stellar association AB Doradus and the Pleiades has allowed to confirm the coevality for these two systems. A group of slow-rotating stars in AB Dor, however, have Li abundance considerably higher that suggested by the general trend, which may be indicative of differences in the rotational histories of stars belonging to the young loose association. A young nearby cluster, gamma2 Velorum, has also been analyzed, using data from the Gaia-ESO survey. This latter has evidenced the presence of two possible different populations. These populations are kinematically different eventual differences in Li abundance are found below detectability.
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Morrison, Alan R. "Poly(ADP)-Ribose Polymerase Activity in the Eukaryotic Mono-ADP-Ribosyl Transferase, ART2: a Dissertation." eScholarship@UMMS, 2003. https://escholarship.umassmed.edu/gsbs_diss/126.
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The glycophosphatidylinositol(GPI)-linked membrane protein ART2 is an antigenic determinant for T lymphocytes that regulate the expression of diabetes in the BB/W rat model. Though little is understood of the physiologic role of ART2 on T lymphocytes, ART2 is a member of the mono-ADP-ribosyl transferase subgroup ofthe ADP-ribosyl transferase (ART) protein family. The ART protein family, which traditionally has been divided into mono-ADP-ribosyl transferases (mono-ARTs), poly(ADP)-ribose polymerases (PARPs), and ADP-ribosyl cyclases, influences various aspects of cellular physiology including: apoptosis, DNA damage repair, chromatin remodeling, telomere replication, cellular transport, immune regulation, neuronal function, and bacterial virulence. A structural alignment of ART2.2 with chicken PARP indicated the potential for ART2.2 to catalyze ADP-ribose polymers in an activity thought to be specific to the PARP subgroup and important for their regulation of nuclear processes. Kinetic studies determined that the auto-ADP-ribosyl transferase activity of ART2.2 is multitmeric and heterogeneous in nature. Hydroxylamine-cleaved ADP-ribose moieties from the ART2.2 multimers ran as polymers on a modified sequencing gel, and digestion of the polymers with snake-venom phosphodiesterase produced AMP and the poly(ADP)ribose-specific product, PR-AMP, which was resolved by analytical HPLC and structurally confirmed by ESI-MS. The ratio of AMP to PR-AMP was higher than that of PARP raising the possibility that the ART2.2 polymers had a different branching structure than those of PARP. This alternative branching was confirmed by the presence of ribose phosphate polymers in the snake venom phophodiesterase treated samples. The site of the auto-poly(ADP)-ribose modification was determined to be R185, a residue previously proposed to influence the level of auto-ADP ribosylation of ART2.2 by mutational analysis. These data provide the first demonstration of a hybrid between mono-ARTs and PARPs and are the earliest indication that PARP-like enzymes can exist outside the nucleus and on the cell surface.
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Krasney, Martin. "Die Anwendbarkeit des Kartellrechts auf die Rahmenverträge in der Gesetzlichen Krankenversicherung am Beispiel der Verträge nach [Para][Para] 125 Abs. 2, 127 Abs. 1 SGB V /." [S.l. : s.n.], 2005. http://swbplus.bsz-bw.de/bsz117178268inh.htm.
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Cattelan, Arianna. "Effetto delle microparticelle endoteliali sulla funzionalità endoteliale: ruolo di miR-126 e di GLP-1R." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423643.
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Introduction: Microparticles are membrane vesicles shed from the plasma membrane of endothelial cells generated in physiological and pathological conditions. Recent studies have shown that EMP may represent important transporters for cytokines, proteins and microRNA. The aim of this study was to investigate, in endothelial cells, the effect of microparticles (EMP) from HCAEC exposed to normal-glucose condition or to high-glucose con-dition (iEMP) on miR-126 expression, on cell proliferation and migration.
Methods: EMP were generated from HCAEC exposed to basal medium without growth supplements for 24 h. Microparticles derived from glucose-trated HCAEC were defined as “injured” EMP (iEMP). HCAEC were in-cubated with EMP or iEMP for 24 h. Microarray analysis was performed by TaqMan microRNA Array. miR-126 expression was determined by qPCR Real-Time, SPRED-1 and GLP-1R protein expression by Western Blot. Cell proliferation was measured using xCELLigence system (Roche) and cell migration by Scratch Assay.
Results: EMP promote cell proliferation and migration by delivering func-tional miR-126 into recipient cells. This leads to downregulation of target protein SPRED-1, a negative modulator of Ras/ERK pathway. iEMP, which contain a lower amount of miR-126 in comparison to EMP, reduce cell pro-liferation by repressing GLP-1R protein expression and by decreasing ERK pathway activation.
Conclusion: This study demonstrates for the first time that endothelial func-tion may be improved by EMP through a release of miR-126 but not in the presence of iEMP. Therefore, EMP may represent a new opportunity to transfer a desired biological message into target cells as therapeutic tool in cardiovascular diseases.<br>Introduzione: Le microparticelle (EMP) sono piccole vescicole liberate dalla superficie di membrana di cellule endoteliali in condizioni sia fisiolo-giche che patologiche. Recenti studi hanno messo in evidenza che le EMP rappresentano trasportatori di microRNA capaci di modulare la funzionalità endoteliale con meccanismi non ancora definiti. E’ noto che l’attività proli-ferativa delle cellule endoteliali viene regolata da recettori “accoppiati alla proteina G”, come il recettore GLP-1 (GLP1R).Obiettivo di questo studio è stato di verificare l’effetto delle microparticelle ottenute da cellule cresciute in condizioni di glucosio normale (EMP) o in condizioni di elevato glucosio (iEMP) sull’espressione di miR-126, sulla proliferazione e sulla migrazione cellulare e sulla espressione di GLP1R nelle cellule endoteliali.
Metodi: Le EMP sono state generate incubando cellule endoteliali umane (HCAEC) per 24h in terreno privo di supplementi di crescita. Le iEMP sono state ottenute pre-stimolando le cellule con elevata concentrazione di gluco-sio (30mM) per 72h. In seguito, le cellule HCAEC sono state incubate con le EMP o con le iEMP per 24h. L’analisi di microarray è stata eseguita me-diante TaqMan® microRNA Array. L’espressione genica di miR-126 è stata determinata mediante qPCR Real Time e l’espressione proteica di GLP1R mediante Western Blot. L’effetto proliferativo di EMP, iEMP è stato valuta-to mediante xCELLigence System (Roche) e la migrazione mediante Scratch Assay.
Risultati: Le EMP favoriscono la proliferazione e la migrazione cellulare mediante il trasferimento di miR-126; miR-126 riduce l’espressione di SPRED-1, proteina che regola negativamente la proliferazione cellulare attraverso l'inibizione della via Ras/ERK chinasi; le iEMP invece, hanno un ridotto contenuto di miR-126, attenuano la proliferazione e la migrazione delle cellule endoteliali; è ipotizzabile che tale meccanismo sia dovuto alla riduzione dell’espressione proteica del recettore GLP-1R. La riduzione dell’espressione di GLP-1R indotta da iEMP inibisce l’attivazione di ERK 1/2, direttamente coinvolta nella regolazione della proliferazione cellulare endoteliale.
Conclusione: Questo studio dimostra per la prima volta che i microRNA presenti nelle microparticelle possono agire da mediatori di comunica-zione intercellulare in quanto possono essere trasferiti all’interno di cel-lule target per modularne diverse attività metaboliche, come la prolifera-zione e migrazione cellulare.
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Hevert, Caroline. "Das private Festnahmerecht nach 127 Abs. 1 S. 1 StPO und seine Bedeutung als Rechtfertigungsgrund /." Aachen : Shaker, 2005. http://www.gbv.de/dms/ilmenau/toc/499543483hever.PDF.
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Anders, Ines. "Die Geschäftsordnung der Hauptversammlung gemäß [Para] 129 Abs. 1 S. 1 AktG : Chancen statt Risiken? /." [S.l. : s.n.], 2003. http://swbplus.bsz-bw.de/bsz114987793inh.htm.
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Hevert, Caroline [Verfasser]. "Das private Festnahmerecht nach § 127 Abs. 1 S. 1 StPO und seine Bedeutung als Rechtfertigungsgrund / Caroline Hevert." Aachen : Shaker, 2005. http://d-nb.info/1186578394/34.
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Haselbauer, Franciele Rechembach. "Produtividade da aveia branca cv. IPR 126 submetida à níveis e formas de parcelamento de nitrogênio em cobertura, com e sem cortes." Universidade Tecnológica Federal do Paraná, 2017. http://repositorio.utfpr.edu.br/jspui/handle/1/2653.
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CAPES<br>A intensificação da produção em sistemas integrados de produção, basifica-se na sustentabilidade do mesmo, buscando os melhores arranjos para sustentação de bons resultados. A adubação é de extrema importância para o sucesso na produtividade, sendo a nitrogenada que requer maior atenção na produção, principalmente, de gramíneas. No cultivo de pastagens muitas vezes há um negligenciamento na adubação, sendo maior quando se trata para cobertura. Com base nesta premissa, o trabalho tem o objetivo de encontrar uma resposta para a adubação nitrogenada aplicada na aveia branca, bem como se esta adubação é mais responsiva em doses únicas ou parceladas, em sistema de cortes e para cobertura vegetal. O experimento foi desenvolvido na UTFPR-DV, em delineamento fatorial 2 x 6 (manejo x níveis de nitrogênio), blocos ao acaso, com três repetições e parcelas subdivididas. As parcelas receberam quatro doses de nitrogênio 0, 60, 120 e 180 kg ha-1 de N associados a três formas de parcelamento do fertilizante (aplicação em dose única bem como o parcelamento das doses de 120 e 180 kg ha-1 de N em duas e três aplicações de 60 kg N ha-1 respectivamente). A adubação nitrogenada foi realizada a lanço, sendo a ureia (45% N) a fonte de nitrogênio utilizada. As avaliações realizadas na aveia foram determinação de taxa de acúmulo, matéria seca, taxa de recuperação e eficiência de uso do nitrogênio e teor de proteína bruta. Os dados obtidos foram submetidos à análise de variância e quando verificado significância pelo teste F as médias foram comparadas pelo Teste Tukey a 5% de probabilidade de erro. A taxa de acumulo média variou de 39,36 a 59,42 kg ha-1 de MS para sem cortes e de 41,73 a 62,67 kg ha-1 de MS com cortes. A produção de matéria seca para sem cortes o acumulado variou de 6240 a 10266,67 kg ha-1 de MS nos níveis estudados, com cortes, foi de 4865 a 7593,33 kg ha-1 de MS. A máxima eficiência técnica foi obtida com 149 kg ha-1 de N. A eficiência do uso do nitrogênio decresceu com o aumento dos níveis de nitrogênio. Em geral, a taxa de recuperação também decresceu com o aumento dos níveis de nitrogênio. A proteína bruta variou para as parcelas sem cortes de 12,1 a 16,06% e com cortes de 13,41 a 16,92%. Conclui-se que houve imobilização de nitrogênio aplicado nas maiores doses, sendo mais expressivo nos tratamentos que não receberam cortes. A partir de 120 kg ha-1 de N o parcelamento pode ser interessante quando não se pode ter perda temporal pela imobilização.<br>The intensification of production in integrated production systems, is based on the sustainability of the same, seeking the best arrangements to sustain good results. Fertilization is of extreme importance for the success in productivity, being nitrogenous that requires more attention in the production, mainly of grasses. In cultivation of pastures there is often negligence in fertilization, being greater when it comes to coverage. Based on this premise, the objective of this work is to find an answer for the nitrogen fertilization applied in white oats, as well as if this fertilization is more responsive in single or split doses, in a system of cuts and for vegetal cover. The experiment was developed in UTFPR-DV, in a 2 x 6 factorial design (management x nitrogen levels), randomized blocks, with three replicates and subdivided plots. The plots received four nitrogen doses 0, 60, 120 and 180 kg ha-1 of N associated to three forms of fertilizer application (single dose application as well as the splitting of doses of 120 and 180 kg ha-1 of N in two and three applications of 60 kg N ha-1 respectively). Nitrogen fertilization was carried out in the haul, with urea (45% N) being the source of nitrogen used. The evaluations carried out in the oats were determination of accumulation rate, dry matter, recovery rate and efficiency of nitrogen use and crude protein content. The data were submitted to analysis of variance and when verified by means of the F test, the means were compared by the Tukey test at 5% error probability. The mean accumulation rate ranged from 39.36 to 59.42 kg ha-1 of DM for uncut and 41.73 to 62.67 kg ha-1 of DM with cuts. The dry matter yield for uncrowded accumulated varied from 6240 to 10266.67 kg ha-1 of DM at the studied levels, with cuts, from 4865 to 7593.33 kg ha-1 of MS. The maximum technical efficiency was obtained with 149 kg ha-1 of N. The efficiency of the use of nitrogen decreased with the increase of the nitrogen levels. In general, the recovery rate also decreased with increasing nitrogen levels. The crude protein varied for the plots without cuts of 12.1 to 16.06% and with cuts of 13.41 to 16.92%. It was concluded that there was immobilization of nitrogen applied at higher doses, being more expressive in treatments that did not receive cuts. From 120 kg ha-1 of N, the splitting can be interesting when there is no temporal loss due to immobilization.
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Triglia, Denise Goffi [UNESP]. "Caracterização molecular do arco da alça V3 da gp 120 do HIV-1." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/88049.
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triglia_dg_me_botfm.pdf: 753832 bytes, checksum: 1548d01f8015f2a3aa0616b8f844936a (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Ministério da Saúde<br>Secretaria do Estado da Saúde de São Paulo<br>O HIV-1 é um retrovirus que possui grande variabilidade genética, principalmente no gene que codifica o envelope viral (env). A diversidade de seqüências encontrada na terceira alça variável (alça V3) da gp120 é relacionada a várias características biológicas virais, tais como: habilidade do vírus a induzir sincício, antigenicidade e tropismo viral. O arco da alça V3 é formado por uma seqüência de aminoácidos relativamente conservada (GPGR) nos vírus do subtipo B. No Brasil, encontramos a variante B , que possui a seqüência GWGR formando a região do arco e tem sido associada a uma progressão mais lenta da infecção. O fenótipo viral Não Indutor de Sincício (NSI) predomina nas fases assintomáticas, enquanto que o fenótipo Indutor de Sincício (SI) emerge em indivíduos infectados precedendo um declínio acentuado de células T CD4, sendo associado à progressão para aids. A mudança do fenótipo NSI para SI é resultante da substituição de determinados aminoácidos na alça V3. Mutações que alterem a seqüência de aminoácidos da alça V3, incluindo a região do arco podem ser utilizadas como marcadores genéticos para inferir sobre a evolução da infecção. DNA viral foi isolado a partir de leucócitos e utilizado como fonte para amplificação por PCR e seqüenciamento automático da região da alça V3. Um script desenvolvido pelo setor de Bioinformática foi utilizado para identificar os fenótipos SI/NSI e a seqüência de aminoácidos do arco da alça V3 (GPGR/GWGR) em 1279 pacientes estudados no Estado de São Paulo como parte do projeto VGDN. Esse estudo mostrou que 34,8% dos pacientes possuíam os aminoácidos GPGR formando a região do arco enquanto que 22,8% possuíam GWGR. Além disso, análises estatísticas utilizando o Teste de Goodman apontaram uma prevalência significativa de GWGR em pacientes assintomáticos com fenótipo NSI...<br>Genomic diversity in HIV-1 is a well-characterized feature and although this heterogeneity is distributed throughout the genome, most of the polymorphisms are located in the envelope gene (env). Sequence variability at the env gene third variable region (V3 loop) of HIV-1 is highly correlated with several viral biological features, such as the ability to induce syncytia, antigenicity and viral tropism. The tip of V3 loop consists of a relative conserved amino acid sequence (GPGR) in subtype B and the presence of GWGR motif in this region has been found in Brazilian strains (B' variant). Non-syncytium-inducing (NSI) phenotype variants predominate in the asymptomatic phase and Sincytium-inducing (SI) phenotype variants emerge in infected patients preceding a CD4 cell decline and correlate with progression to clinical manifestations. The switch from an NSI to an SI phenotype was correlated with one or more basic amino acids substitutions in the V3 loop. Genetic mutations modifying the V3 sequence has been associated with alterations in cytopathic abilities and antigenicity. The patterns of the HIV-1 sequences variability can be used as genetic marker to infer about the infection evolution. Viral DNA isolated from leucocytes was used as a source for PCR amplification and automatic sequencing of the V3 loop gene. Home-made PERL scripts were used to identify NSI/SI phenotypes and GPGR/GWGR motif in 1279 patients studied in São Paulo State, Brazil, as part of VGDN Project (www.lemb.icb.usp.br). This study showed that 34.8% of the patients have had GPGR variants and 22.8% GWGR. In addiction, statistical analysis using Goodman's Test showed GWGR prevailed in asymptomatic patients with NSI strains... (Complete abstract click electronic access below)
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Triglia, Denise Goffi. "Caracterização molecular do arco da alça V3 da gp 120 do HIV-1 /." Botucatu : [s.n.], 2007. http://hdl.handle.net/11449/88049.
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Orientador: Maria Inês de Moura Campos Pardini<br>Banca: Isabel Maria Vicente Guedes Carvalho-Mello<br>Banca: Domingos Alves Meira<br>Resumo: O HIV-1 é um retrovirus que possui grande variabilidade genética, principalmente no gene que codifica o envelope viral (env). A diversidade de seqüências encontrada na terceira alça variável (alça V3) da gp120 é relacionada a várias características biológicas virais, tais como: habilidade do vírus a induzir sincício, antigenicidade e tropismo viral. O arco da alça V3 é formado por uma seqüência de aminoácidos relativamente conservada (GPGR) nos vírus do subtipo B. No Brasil, encontramos a variante B, que possui a seqüência GWGR formando a região do arco e tem sido associada a uma progressão mais lenta da infecção. O fenótipo viral Não Indutor de Sincício (NSI) predomina nas fases assintomáticas, enquanto que o fenótipo Indutor de Sincício (SI) emerge em indivíduos infectados precedendo um declínio acentuado de células T CD4, sendo associado à progressão para aids. A mudança do fenótipo NSI para SI é resultante da substituição de determinados aminoácidos na alça V3. Mutações que alterem a seqüência de aminoácidos da alça V3, incluindo a região do arco podem ser utilizadas como marcadores genéticos para inferir sobre a evolução da infecção. DNA viral foi isolado a partir de leucócitos e utilizado como fonte para amplificação por PCR e seqüenciamento automático da região da alça V3. Um script desenvolvido pelo setor de Bioinformática foi utilizado para identificar os fenótipos SI/NSI e a seqüência de aminoácidos do arco da alça V3 (GPGR/GWGR) em 1279 pacientes estudados no Estado de São Paulo como parte do projeto VGDN. Esse estudo mostrou que 34,8% dos pacientes possuíam os aminoácidos GPGR formando a região do arco enquanto que 22,8% possuíam GWGR. Além disso, análises estatísticas utilizando o Teste de Goodman apontaram uma prevalência significativa de GWGR em pacientes assintomáticos com fenótipo NSI... (Resumo completo, clicar acesso eletrônico abaixo)<br>Abstract: Genomic diversity in HIV-1 is a well-characterized feature and although this heterogeneity is distributed throughout the genome, most of the polymorphisms are located in the envelope gene (env). Sequence variability at the env gene third variable region (V3 loop) of HIV-1 is highly correlated with several viral biological features, such as the ability to induce syncytia, antigenicity and viral tropism. The tip of V3 loop consists of a relative conserved amino acid sequence (GPGR) in subtype B and the presence of GWGR motif in this region has been found in Brazilian strains (B' variant). Non-syncytium-inducing (NSI) phenotype variants predominate in the asymptomatic phase and Sincytium-inducing (SI) phenotype variants emerge in infected patients preceding a CD4 cell decline and correlate with progression to clinical manifestations. The switch from an NSI to an SI phenotype was correlated with one or more basic amino acids substitutions in the V3 loop. Genetic mutations modifying the V3 sequence has been associated with alterations in cytopathic abilities and antigenicity. The patterns of the HIV-1 sequences variability can be used as genetic marker to infer about the infection evolution. Viral DNA isolated from leucocytes was used as a source for PCR amplification and automatic sequencing of the V3 loop gene. Home-made PERL scripts were used to identify NSI/SI phenotypes and GPGR/GWGR motif in 1279 patients studied in São Paulo State, Brazil, as part of VGDN Project (www.lemb.icb.usp.br). This study showed that 34.8% of the patients have had GPGR variants and 22.8% GWGR. In addiction, statistical analysis using Goodman's Test showed GWGR prevailed in asymptomatic patients with NSI strains... (Complete abstract click electronic access below)<br>Mestre
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Ezenwa, Anne Marie. "Ecclesial and Nigerian legal perspectives on employment of workers, application of Canon 1286, 1°." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ48201.pdf.
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Hamoudi, Meriem. "Exploration des contraintes génétiques et structurelles à la génération de formes du VIH-1 portant des enveloppes recombinantes." Thesis, Strasbourg, 2012. http://www.theses.fr/2012STRAJ125.
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Le VIH, grâce à sa variabilité génétique, présente une grande capacité à échapper au système immunitaire et s’adapter à l’environnement. La recombinaison, source importante de cette variabilité, est illustrée par le grand nombre de formes recombinantes observées dans l’épidémie. Le laboratoire s’est intéressé à l’étude de ce mécanisme et des lois qui gouvernent l’apparition de ces formes et ce en se focalisant sur la recombinaison inter sous-types d’isolats primaires le long du gène de l’enveloppe. En plus de mettre en évidence les paramètres impliqués dans la génération et la sélection de ces formes dans la nature, le laboratoire a pu déterminer qu’une majorité des recombinants dans la région C2 du gène de l’enveloppe présente des défauts majeurs de fonctionnalité. Ces défauts étaient sans doute dus à une incompatibilité entre les deux portions de sous-types différents réassociées par la recombinaison. Afin d’identifier les régions impliquées dans cette perte de fonctionnalité, des chimères entre différents sous-types ont été construites et testées en entrée virale. Ces chimères présentent la région C2, V1V2 et V3 de sous-types différents du reste de la protéine. Les résultats obtenus ont permis de mettre en évidence que les régions V1V2 et C2 sont importantes pour le maintien de la fonctionnalité des protéines et que V1V2 est essentielle au maintien de l’interaction entre les sous-unités de l’enveloppe, la gp120 et la gp41. Cette étude a donc permis de déterminer que V1V2 et C2 font partie d’un réseau de coévolution important impliquant des interactions indispensables au maintien de la fonctionnalité de la protéine<br>HIV presents a high genetic variability that is necessary for the virus to escape to the host immune response and to adapt to the environment. Recombination is an important source of this variability and contributes to the generation of recombinant forms in the epidemic. Using inter subtypes from primary isolates, the laboratory focused on the study of recombination along the envelope gene and the determination of the parameters involved in the generation and selection of these recombinant forms. Previous works in the laboratory showed that a majority of recombinants in C2 region of the envelope gene displayed an important loss of function. This loss was probably due to an incompatibility of the parts associated by recombination and that come from different origins. To identify the regions involved in the loss of functionality of these recombinants, chimeras where C2 and surrounding regions (V1V2 and V3) from a different subtype than the rest of the gene, were created and tested for their ability to mediate viral entry. The functionality tests showed that V1V2 and C2 are important to maintain the functionality of the protein. Indeed, V1V2 seem to be involved in the stability of the Env trimer by maintaining the interaction between the two subunits of the protein, gp120/gp41. This work shows that V1V2 and C2 regions are involved in a coevolution network and their interactions with other portions are essential to maintain the functionality of the protein
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Reitemeier, Wiebke. "Täuschungen vor Abschluß von Arbeitsverträgen : zum Verhältnis zwischen dem Straftatbestand des Betruges und dem Anfechtungsrecht wegen arglistiger Täuschung ( 263 Abs. 1 StGB, 123 Abs. 1 Alt. 1 BGB) /." Frankfurt am Main [u.a.] : Lang, 2001. http://www.gbv.de/dms/sbb-berlin/325796475.pdf.
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Iskander, Sammy. "Characterisation [i.e. characterization] of HIV-1 glycoprotein 120 neurotoxicity in primary human serum-free CNS cultures." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape4/PQDD_0021/MQ58045.pdf.
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Petersdotter, Eriksson Karin. "Johannes Brahms sonat i F-moll op. 120 no. 1 : ett verk för viola eller klarinett?" Thesis, Kungl. Musikhögskolan, Institutionen för klassisk musik, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kmh:diva-1898.
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<p>Examination:</p><p>J.S Bach, prelude ur svit no. 3 i C-dur för solo violaJ. Brahms, Allegro Appassionata ur sonat i F-moll op. 120 no. 1W. Walton, andante comodo ur konsert för viola och orkesterVid flygeln, Erik Lanninger</p>
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Milinis, Albertas. "Criminal Liability for Murder without Circumstances Aggravating and Mitigating (Part 1 Art. 129 of the Criminal Code)." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2009. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2009~D_20090507_135323-23627.
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Subject of the dissertation research – analysis of the body of murder without circumstances aggravating and mitigating its gravity provided for in Part 1 Art. 129 of the Criminal Code of the Republic of Lithuania as well as analysis of theoretical and practical problems that arise upon qualifying these criminal acts. The goal of this research is to reveal a concept of murder without circumstances aggravating and mitigating its gravity where punishment is imposed in accordance with Part 1 Art. 129 of the CC of the Republic of Lithuania, to analyse attributes of this criminal act, to raise theoretical and practical problems of qualification of the analysed criminal act and to make proposals for solution of these problems.<br>Disertacijos tyrimo dalykas – nužudymo be jo pavojingumą didinančių ir mažinančių aplinkybių, numatyto Lietuvos Respublikos baudžiamojo kodekso (toliau tekste – LR BK) 129 str. 1 d., sudėties analizė bei teorinių ir praktinių problemų, kylančių kvalifikuojant šias nusikalstamas veikas, tyrimas. Disertacijos tyrimo tikslas – atskleisti nužudymo be jo pavojingumą didinančių ar mažinančių aplinkybių, už kurį kyla baudžiamoji atsakomybė pagal LR BK 129 straipsnio 1 dalį, sampratą, išanalizuoti šios nusikalstamos veikos požymius, iškelti nagrinėjamos nusikalstamos veikos teorines ir praktines kvalifikavimo problemas bei pateikti pasiūlymus šių problemų sprendimui.
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Schnell, Jacqueline [Verfasser]. "Das Saure-Prostata-Phosphatase-Fragment 85-120 bildet Amyloidfibrillen und verstärkt die HIV-1-Infektion / Jacqueline Schnell." Ulm : Universität Ulm. Medizinische Fakultät, 2013. http://d-nb.info/1038004942/34.
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Freyberger, Bert. "Südgallien im 1. Jahrhundert v. Chr. : Phasen, Konsequenzen und Grenzen römischer Eroberung (125 - 27-22 v. Chr.) /." Stuttgart : F Steiner, 1999. http://catalogue.bnf.fr/ark:/12148/cb37630780d.
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Beck, Florence. ""Fragerecht" und "Recht zur Lüge" : allgemeine Grundsätze und bereichsspezifische Besonderheiten der Anfechtbarkeit nach [Para] 123 Abs. 1 Alt. 1 BGB bei einer Befragung des Täuschenden /." Frankfurt am Main ; Berlin ; Bern ; Wien [u.a.] : Lang, 2004. http://swbplus.bsz-bw.de/bsz11286614xvlg.htm.
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Bütefisch, Wylka. "Die Sozialauswahl : praxisorientierte Darstellung der 1 Abs. 3, 4 KSchG und 125 Abs. I S.I Nr. 2 InsO /." Köln : Schmidt, 2000. http://www.gbv.de/dms/spk/sbb/recht/toc/312024495.pdf.
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Plag, Ralf. "Absolutbestimmung der 12C([alpha],[gamma])16O-Rate [12-C-(alpha,gamma)-16-0-Rate] im Energiebereich um 1 MeV." Karlsruhe : FZKA, 2005. http://bibliothek.fzk.de/zb/berichte/FZKA7099.pdf.
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Dey, Antu Kanti. "Structural characterisation of RNA aptamers against the gp 120 surface envelope glycoprotein of a macrophage tropic strain of HIV-1." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409036.
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Woo, Ho-Hyung, Csaba Laszlo, Stephen Greco, and Setsuko Chambers. "Regulation of colony stimulating factor-1 expression and ovarian cancer cell behavior in vitro by miR-128 and miR-152." BioMed Central, 2012. http://hdl.handle.net/10150/610206.
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BACKGROUND:Colony stimulating factor-1 (CSF-1) plays an important role in ovarian cancer biology and as a prognostic factor in ovarian cancer. Elevated levels of CSF-1 promote progression of ovarian cancer, by binding to CSF-1R (the tyrosine kinase receptor encoded by c-fms proto-oncogene).Post-transcriptional regulation of CSF-1 mRNA by its 3' untranslated region (3'UTR) has been studied previously. Several cis-acting elements in 3'UTR are involved in post-transcriptional regulation of CSF-1 mRNA. These include conserved protein-binding motifs as well as miRNA targets. miRNAs are 21-23nt single strand RNA which bind the complementary sequences in mRNAs, suppressing translation and enhancing mRNA degradation.RESULTS:In this report, we investigate the effect of miRNAs on post-transcriptional regulation of CSF-1 mRNA in human ovarian cancer. Bioinformatics analysis predicts at least 14 miRNAs targeting CSF-1 mRNA 3'UTR. By mutations in putative miRNA targets in CSF-1 mRNA 3'UTR, we identified a common target for both miR-128 and miR-152. We have also found that both miR-128 and miR-152 down-regulate CSF-1 mRNA and protein expression in ovarian cancer cells leading to decreased cell motility and adhesion in vitro, two major aspects of the metastatic potential of cancer cells.CONCLUSION:The major CSF-1 mRNA 3'UTR contains a common miRNA target which is involved in post-transcriptional regulation of CSF-1. Our results provide the evidence for a mechanism by which miR-128 and miR-152 down-regulate CSF-1, an important regulator of ovarian cancer.
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Artaud, Laurent. "Mise au point d'un radiotraceur 1-125 IMAO B : marquage de la molécule, purification, liposolubilité, biodistribution animale et imagerie Gamma." Paris 5, 1993. http://www.theses.fr/1993PA05P183.
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ROGE, PHILIPPE. "Syndrome d'hyperstimulation ovarienne en procreation medicalement assistee : approche physiopathologique." Aix-Marseille 2, 1994. http://www.theses.fr/1994AIX20727.
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Gorbinet, Thomas. "Étude des réactions de spallation 136Xe + p et 136Xe + 12C à 1 GeV par nucléon auprès de l'accélérateur GSI (Darmstadt, Allemagne)." Phd thesis, Université Paris Sud - Paris XI, 2011. http://tel.archives-ouvertes.fr/tel-00660583.
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Les réactions 136Xe + p et 136Xe + 12C à 1 GeV par nucléon d'énergie cinétique du projectile dans le centre de masse ont été étudiées en cinématique inverse à l'aide du dispositif expérimental SPALADIN, installé auprès de l'accélérateur d'ions lourds de GSI. Ma thèse décrit l'analyse de ces collisions réalisées au printemps 2009. La détection en coïncidence des fragments de l'état final (résidu du projectile, neutrons et fragments légers chargés) avec une grande efficacité géométrique est obtenue par la combinaison de la cinématique inverse, d'un aimant dipolaire de grande ouverture physique et de l'utilisation de grands détecteurs. Ces coïncidences, mesurées événement par événement, nous ont permis de sélectionner, indépendamment du modèle de désexcitation, le pré-fragment, noyau excité issu de la cascade intranucléaire en fonction de son énergie d'excitation. Ainsi, nous avons pu étudier l'évolution du mécanisme de désexcitation (par exemple, l'évaporation de particules légères, la cassure binaire asymétrique ou la fragmentation multiple simultanée) en fonction de l'énergie d'excitation du pré-fragment. Les données de la réaction 136Xe + p sont comparées principalement à trois modèles de désexcitation (SMM, GEMINI++ et ABLA07) couplés au code de cascade intranucléaire INCL4. Si ces modèles semblent décrire globalement les observables de notre expérience, des désaccords significatifs sont apparus notamment en ce qui concerne la production des fragments de masse intermédiaire (IMF). La comparaison des données 136Xe + 12C avec celles de la réaction 136Xe + p fait apparaître une grande similitude dans la désexcitation des pré-fragments qui laisse entrevoir que la cascade intranucléaire mène, dans les deux cibles, aux mêmes types de pré-fragments sur la plage d'énergie d'excitation commune aux deux réactions (0 à 4 MeV par nucléon). Le régime d'excitation au-dessus de 4 MeV par nucléon, accessible uniquement pour la réaction 136Xe + 12C, montre une différence qualitative dans la désexcitation du pré-fragment, avec notamment une production beaucoup plus importante d'IMF, avec des multiplicités élevées par événement, qui croît avec l'énergie d'excitation.
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Gorbinet, Thomas. "Étude des réactions de spallation 136Xe + p et 136Xe + 12C à 1 GeV par nucléon auprès de l’accélérateur GSI (Darmstadt, Allemagne)." Thesis, Paris 11, 2011. http://www.theses.fr/2011PA112237/document.
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Les réactions 136Xe + p et 136Xe + 12C à 1 GeV par nucléon d’énergie cinétique du projectile dans le centre de masse ont été étudiées en cinématique inverse à l’aide du dispositif expérimental SPALADIN, installé auprès de l’accélérateur d’ions lourds de GSI. Ma thèse décrit l’analyse de ces collisions réalisées au printemps 2009. La détection en coïncidence des fragments de l’état final (résidu du projectile, neutrons et fragments légers chargés) avec une grande efficacité géométrique est obtenue par la combinaison de la cinématique inverse, d’un aimant dipolaire de grande ouverture physique et de l’utilisation de grands détecteurs. Ces coïncidences, mesurées événement par événement, nous ont permis de sélectionner, indépendamment du modèle de désexcitation, le pré-fragment, noyau excité issu de la cascade intranucléaire en fonction de son énergie d’excitation. Ainsi, nous avons pu étudier l’évolution du mécanisme de désexcitation (par exemple, l’évaporation de particules légères, la cassure binaire asymétrique ou la fragmentation multiple simultanée) en fonction de l’énergie d’excitation du pré-fragment. Les données de la réaction 136Xe + p sont comparées principalement à trois modèles de désexcitation (SMM, GEMINI++ et ABLA07) couplés au code de cascade intranucléaire INCL4. Si ces modèles semblent décrire globalement les observables de notre expérience, des désaccords significatifs sont apparus notamment en ce qui concerne la production des fragments de masse intermédiaire (IMF). La comparaison des données 136Xe + 12C avec celles de la réaction 136Xe + p fait apparaître une grande similitude dans la désexcitation des pré-fragments qui laisse entrevoir que la cascade intranucléaire mène, dans les deux cibles, aux mêmes types de pré-fragments sur la plage d’énergie d’excitation commune aux deux réactions (0 à 4 MeV par nucléon). Le régime d’excitation au-dessus de 4 MeV par nucléon, accessible uniquement pour la réaction 136Xe + 12C, montre une différence qualitative dans la désexcitation du pré-fragment, avec notamment une production beaucoup plus importante d’IMF, avec des multiplicités élevées par événement, qui croît avec l’énergie d’excitation<br>The collision of 136Xe with the proton and with 12C at 1 GeV per nucleon of projectile kinetic energy in the centre of mass has been studied in inverse kinematics using the SPALADIN experimental setup at the GSI facility. This manuscript describes the analysis of these collisions realized in spring 2009. The detection in coincidence of the final state fragments (projectile residues, neutrons and light charged fragments) with a large geometrical efficiency is provided by the inverse kinematics combined with a large aperture dipole magnet and large detectors. Such a coincidence, measured on an event basis, allows selecting, in a model-independent way, the prefragment, the excited nuclear system formed after the intranuclear cascade as a function of its excitation energy. Hence, we were able to study the evolution of the prefragment deexcitation mechanism (evaporation of light particles, asymmetric binary decay, multiple fragmentation…) as a function of its excitation energy. The data of the 136Xe + p reaction have been compared mainly to three deexcitation models (SMM, GEMINI++ and ABLA07) coupled to the intranuclear cascade code INCL4. Despite the relatively good and global agreement between these models and our data, significant discrepancies appeared concerning in particular the production of intermediate mass fragments (IMF). Comparison between the 136Xe + 12C and the 136Xe + p data exhibits an important similarity in the deexcitation of the pre-fragments. This suggests that the nuclear cascade leads, for both targets, to similar prefragment types in the range of excitation energy (0 to 4 MeV per nucleon) common to both reactions. Higher excitation energies, reached only in the 136Xe + 12C reaction, show a qualitative difference in the deexcitation of the pre-fragment, with much higher multiplicities of IMF per event, increasing with the excitation energy
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LEIBOVICH, ERNESTO. "Les rapports du langage et de l'etre dans la philosophie d'heraclite. Essai d'interpretation des fragments (d. K. ) 1, 93 et 123." Paris 4, 1994. http://www.theses.fr/1994PA040056.
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Cette interpretation conjointe des trois fragments d'heraclite (b 93, b 123, b 1) a comme pointe de depart le sens accorde a semainein dans b 93 : "produire des semata". Ce fragment affirme que le dieu oute kruptei, et b 123 que la phusis kruptesthai philei. Si les semata du dieu sont presents dans la phusis, celle-ci ne "se cache" pas elle-meme - comme le veut la traduction consacree -, mais plutot "garde en elle-meme" les signes envoyes par le dieu. - le rapport entre les trois fragments s'organise autour de la question pour l'activite propre (oikeion ergon) : au dieu (semainein, b 93), a la phusis (kruptesthai, b 123), a l'homme (legein, b 1). Le logos de b 1 est une metaphore lourde de consequences philosophiques : heraclite appelle le sema divin un "discours", c'est-a-dire qu'il le compare avec le langage humain commun et universel (xunos, koinos), comprehensible en principe par tous les hommes et present non seulement a delphes, mais dans toute la phusis. L'analyse des sources de b 93 et de b 123 chez plutarque, philon, themistios, julien et proclus prouve que malgre les differents contextes philosophiques la relation entre phusis et kruptesthai a toujours ete comprise selon le mecanisme du semainein : la phusis ne se cache pas, mais garde les semata divins<br>The kev to this joint interpretation of three fragments of heraclitus (b 93, b 123, b 1) is the meaning given to semainein in b 93 : "producing semata". This fragment says that the god oute kruptei, and b 123 says that the phusis kruptesthai philei. If the semata of the god are present in the physis, then it does not "hide itself" - as the usual translation says - but it rather "keeps in herself" the semata sent by the god. - the relation between these three fragments is based on the question about the characteristic activity (oikeion ergon) of the god (semainein, b 93), of the phusis (kruptesthai, b 123), and of man (legein, b 1). The word logos in b 1 should be considered as a metaphor full of philosophical consequence, heraclitus calls the divine sema a kind of "logos", comparing it to human panguage which is common and universal (xunos, koinos), understandable in principle by all men, present not only at delphi, but evervwhere in the phusis. The study of the sources of b 93 and b 123 (plutarchus, philo, themistius, julian) shows that in spite of the different philosoophical contexts the relation between phusis and kruptesthai has always been understood according to the mechanism of semainein, that is ; the phusis does not "hide itself", but it "keeps in its own bosom" the divine semata
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Braband, Anke. "Branchiopoda und Astacida (Arthropoda, Crustacea)." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2004. http://dx.doi.org/10.18452/15160.
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Innerhalb der Arthropodensystematik sind die phylogenetischen Beziehungen der höheren Crustaceataxa seit langem von besonderen Interesse. Ziel dieser Arbeit ist die Rekonstruktion der phylogenetischen Verwandtschaftsverhältnisse mit Hilfe molekularer Datensätze für die Phyllopoda, die zusammen mit den Anostraca die Branchiopoda bilden und der Astacoidea (Astacida), einer Teilgruppe der Flusskrebse. Folgende molekulare Marker kamen zum Einsatz: 1) Für die Phyllopoda: Die 3. Domäne der mitochondrial codierten 12S rRNA, unter Berücksichtigung von Sekundärtrukturinformationen, das nukleare Gen EF-1 alpha und die Positionen von Introns im Gen EF-1 alpha. 2) Für die Astacoidea: Die 3. Domäne der 12S rRNA und das mitochondrial codierte Gen cox1. Durch die Wahl der molekularen Marker, die mit unterschiedlichen computerkladistischen Methoden ausgewertet wurden, konnten für die meisten Fragen eine eindeutige und im Fall der Astacoidea überraschende phylogenetische Aussage getroffen werden. Die gewonnenen Hypothesen werden ausführlich im Licht morphologischer Hypothesen diskutiert.<br>The phylogenetic relationships of the higher arthropod taxa are still of special interest. Especially the interrelationships of the different Crustacea taxa have long been debated. The focus of this investigation is to make a contribution to the phylogenies of two Crustacea taxa using molecular markers: The Phyllopoda which belong together with the Anostraca to the branchiopods, and of the Astacoidea, one of the two higher crayfish taxa (Astacida). The following molecular markers were used: 1) Phyllopoda: the 3rd domain of the mitochondrial encoded 12S rRNA taking into account informations of the secondary structure, the nuclear encoded proteingene EF-1 alpha and the positions of introns found in the coding region of EF-1 alpha. 2) Astacoidea: the 3rd domain of the 12S rRNA and the mitochondrial encoded proteingene cox1. The choice of the mentioned markers in combination with different computercladistical methods allowed to give a satisfying, and in the case of the Astacoidea a more surprising answer to most addressed phylogenetic questions. The gained hypotheses are then discussed in detail in the light of morphological features and hypotheses.
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Oliveira, Ketti Gleyzer de. "Níveis de expressão de miR-33a e miR-122 em pacientes cronicamente infectados pelo vírus da Hepatite C genótipos 1 e 3." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5168/tde-22012016-104146/.
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Estima-se que 3% da população mundial esteja infectada pelo vírus da hepatite C (HCV). O HCV tem como alvo o tecido hepático e a maioria dos pacientes infectados desenvolvem infecção crônica. Nos últimos anos, estudos in vitro têm demonstrado interações entre o miRNA-122 (miR-122) da célula hospedeira e dois sítios localizados na região 5\' UTR do genoma do vírus da hepatite C (HCV), os quais são essenciais ao processo de replicação viral. O miR-122 é altamente expresso no fígado, onde atua na regulação do metabolismo de lipídios juntamente com outro miRNA, o miRNA-33a (miR-33a), porém, o mecanismo envolvido nesta regulação ainda é pouco conhecido. Sabe-se que a infecção pelo HCV altera a expressão de genes envolvidos na biossíntese e transporte de lipídios, resultando na estimulação do metabolismo de lipídios e criando um ambiente favorável para sua replicação. Neste contexto os objetivos deste trabalho foram avaliar a expressão de miR-33a e miR-122 em indivíduos cronicamente infectados pelo HCV-1 e HCV-3 em amostras obtidas antes do início da terapia. Os miRNAs foram isolados a partir de amostras de sangue periférico e de tecido hepático. A quantificação da expressão relativa de ambos miRNAs foi pela técnica de PCR em tempo real. Os níveis de miR-33a no sangue periférico foram mais elevados do que no tecido hepático em indivíduos infectados pelo HCV-1(p < 0,0001) e HCV-3 (p=0,0025). Observou-se uma correlação inversa entre os níveis de miR-33a no sangue periférico e tecido hepático dos indivíduos infectados pelo HCV-1 (r=-0,281, p=0,039) e correlação positiva para os indivíduos infectados pelo HCV-3 (r=0,9286, p < 0,0001). Correlação inversa entre os níveis hepáticos de miR-33a com o nível sérico de insulina (r=-0,371, p =0,005) nos indivíduos infectados pelo HCV-1 e correlação positiva entre os níveis no sangue periférico com os níveis séricos de GGT (r=0,553, p=0,049) foram observadas. Em relação ao miR-122, de maneira geral o nível hepático foi mais elevado do que o sérico (p < 0,0001). Entretanto, o nível hepático de miR-122 em indivíduos infectados pelo HCV-3 foi maior quando comparado aos infectados pelo HCV-1 (6,22 vezes, p < 0,001). Uma correlação inversa entre os níveis séricos de ApoA-II e os níveis de expressão de miR-122 no sangue (r=-0,330; p=0,014) e tecido hepático (r=-0,311; p=0,020) foi observada nos pacientes infectados pelo HCV-1. Os pacientes infectados pelo HCV- 3 mostraram correlação positiva entre os níveis hepáticos de miR-122 e os níveis de HDL (r=0,412, p=0,036) e insulina (r=0,478, p=0,044). O miR-33a e o miR-122 atuam regulando genes que controlam o metabolismo dos lipídios no fígado. Até o presente momento, não existem relatos que associem a expressão do miR-33a e do miR-122 com o perfil lipídico na infecção pelo HCV. Além disso, o acúmulo de lipídio (esteatose) intensamente descrito na infecção pelo HCV-3 pode sugerir interação diferenciada desse genótipo com os mecanismos envolvidos na regulação do metabolismo lipídico, envolvendo o miR-33a e miR-122<br>The prevalence of infection by hepatitis C virus (HCV) is about 3% of the world population. HCV targets the liver tissue and the majority of infected patients develop chronic infection. In recent years, in vitro studies have demonstrated interactions between miRNA-122 (miR-122) the host cell to two places located in the 5\' untranslated region of the HCV genome which are essential for virus replication process. miR-122 is highly expressed in the liver, which has been implicated as a fatty acid metabolism regulator. Another mine has also been described as a key regulator of lipid metabolism, miRNA-33a (miR-33a), however, the mechanisms involved in this regulation are still little known. It is known that HCV infection changes the expression of genes involved in the biosynthesis and transport of lipids, resulting in stimulation of the lipid metabolism and creating a favorable environment for replication of the virus. To our knowledge, there are no reports linking the expression of miR-33a with lipid profile in HCV infection. In this context the objectives of this study were to evaluate the expression of miR-33a and miR-122 in chronically infected individuals with HCV-1 and HCV-3 in samples obtained prior to initiation of therapy. MiRNAs were isolated from peripheral blood samples and liver tissue. The quantification of relative expression of both miRNAs was by PCR in real time. MiR-33a levels in peripheral blood were higher than in liver tissue in patients infected with HCV-1 (p < 0.0001) and HCV-3 (p=0.0025). Levels in the peripheral blood of miR-33a were lower in patients infected with HCV-3 (p=0.0169). There was an inverse correlation between hepatic levels of miR-33a with serum insulin levels (p=0.005) in individuals infected with HCV-1 and a positive correlation between the levels in the peripheral blood serum levels of GGT (p=0.049). Hepatic levels of miR-122 were higher than the levels in the peripheral blood of individuals infected by HCV-1 and HCV-3 (p < 0.0001). Hepatic miR-122 levels were higher in patients infected with HCV-3 than those infected with HCV-1 (6.22 times, p < 0.001). There was a positive correlation between miR-122 levels in the blood and liver tissue of patients infected with HCV-1 (r=0.302, p=0.026). An inverse correlation between serum ApoA-II was observed in these patients the levels of expression of miR-122 in blood (r=-0.330; p =0.014) and liver tissue (r=-0.311; p=0.020). Patients infected with HCV-3 showed a positive correlation between hepatic miR-122 levels to HDL levels (r=0.412, p=0.036) and insulin levels (r=0.478, p=0.044). The miR-33a and miR-122 act by regulating genes that control lipid metabolism in the liver. The different interactions with lipid metabolism exerted by HCV-3 may explain why his relationship with the miR-33a and miR-122 was different when compared with HCV-1
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Peruzzi, Pierpaolo. "MiR-128 controls the activity of Polycomb Repressor Complexes 1 and 2 in Neural Stem Cells: Implications of its loss in gliomagenesis." The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1366055621.
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Robin, Thierry. "Etude du frittage de la solution solide Pb3(VO4)2(1-x)(PO4)2x dans le cadre du conditionnement de l'iode 129." Limoges, 2000. http://www.theses.fr/2000LIMO0032.
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Dans l'hypothese d'une gestion de l'iode 129 par confinement dans une matrice ceramique, la possibilite d'obtenir des iodoapatites par frittage reactif entre un cur de pbi 2 et pb 3(vo 4) 2 ( 1 x )(po 4) 2 x, a conduit a caracteriser le comportement au frittage de la solution solide constituant l'enrobage. Sept compositions differentes ont ete synthetisees. Les differentes etapes de la reaction de synthese ont ete etudiees pour nous permettre de mieux maitriser l'elaboration de la solution solide : 3pb0 + (1 x)v 2o 5 + 2xnh 4h 2po 4 pb 3(vo 4) 2 ( 1 x )(po 4) 2 x + xh 2o + 2xnh 4oh le caractere auto-entretenu de cette reaction lorsque que x est faible a ete mis en evidence par analyse thermique differentielle. La caracterisation des poudres de la solution solide pb 3(vo 4) 2 ( 1 x )(po 4) 2 x a montre la reproductibilite et l'efficacite du broyage attrition pour obtenir des morphologies controlees et des tailles de grains faibles. Une etude par dilatometrie a permis de determiner que les temperatures optimales de frittage varient nettement avec le degre de substitution x, de 570\c (x = 0) a 710c (x = 1). Une etude de l'evolution de la surface specifique a egalement montre que des mecanismes superficiels non densifiants intervenaient a basse temperature. Une montee rapide en temperature evite de reduire la reactivite des poudres et permet d'elaborer des materiaux denses a grains fins. Grace a ces resultats, deux temperatures adaptees a l'etude des mecanismes de densification et de la croissance granulaire ont ete retenues : 650\c pour l'etude de la densification et de la croissance des grains, et 700\c pour l'etude du grossissement des grains. Pour l'ensemble de la solution solide a l'exception du phosphate de plomb
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Maphalla, Rudene Crystal. "The Section 129(1)(a) Notice as a Prerequisite for Debt Enforcement in terms of the National Credit Act 34 of 2005." Diss., University of Pretoria, 2014. http://hdl.handle.net/2263/46089.
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Avril, Laurence-Emmanuelle. "Interaction entre une sérine-protéase, isolée des membranes de cellules U-937, et la région V3 de la gp 120 de HIV-1." Tours, 1993. http://www.theses.fr/1993TOUR4005.
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Une des étapes de l'interaction entre le rétrovirus HIV-1 et ses cellules cibles implique la reconnaissance de la gp120 par le récepteur CD4. Cependant, certaines cellules murines ainsi que des cellules nerveuses humaines, exprimant le CD4, sont insensibles au virus, laissant supposer l'intervention d'un autre récepteur qui agirait de manière complémentaire ou alternative à celui-ci. De nombreux arguments sont en faveur d'un récepteur de nature enzymatique comme cela a été préalablement démontré sur les lymphocytes Molt4. Nous avons recherché dans les membranes de monocytes U-937, la présence d'un récepteur de ce type pouvant interagir avec la gp120 du virus HIV-1. Nous avons isolé et caractérisé une serine-protéase associée aux membranes de ces cellules dont l'activité enzymatique démontre une spécificité mixte de type trypsique et chymotrypsique sur les substrats chromogéniques et les peptides de synthèse recouvrant la region V3 de la gp120 de HIV-1. L'interaction de ces peptides avec la protéase résulte en une inhibition de l'activité enzymatique. Cette interaction semble être étroitement dépendante de la séquence primaire et de la conformation de chaque peptide, et peut conduire au clivage du peptide au niveau de deux sites principaux déterminés par séquençage NH2-terminal. La protéase monocytaire peut également être inhibée par la gp120 Lai sans que l'on sache actuellement si le clivage observé in vitro est une étape indispensable du mécanisme infectieux. Ces résultats démontrent l'existence d'un nouveau récepteur potentiel pour le virus HIV-1 et peuvent contribuer au développement d'anticorps, diriges contre un épitrope conformation el conserve, qui seraient indépendants de la variabilité structurale des glycoprotéines d'enveloppe, variabilité qui représente le handicap majeur à la réalisation d'un vaccin fiable
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Mild, Andreas, and Martin Natter. "A critical view on recommendation systems." SFB Adaptive Information Systems and Modelling in Economics and Management Science, WU Vienna University of Economics and Business, 2001. http://epub.wu.ac.at/1236/1/document.pdf.
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The literature on recommendation systems indicates that the choice of the methodology significantly influences the quality of recommendations. The impact of the amount of available data on the performance of recommendation systems has not been systematically investigated. We study different approaches to recommendation systems using the publicly available EachMovie data set. In contrast to previous work on this data set, here a significantly higher subset is used. The effects caused by the number of customers and movies as well as their interaction with different methods are investigated. We compare two commonly used collaborative filtering approaches to several regression models using an experimental full factorial design. According to our findings, the number of customers significantly influences the performance of all approaches under study. For a large number of customers and movies, we show that simple linear regression with model selection can provide significantly better recommendations than collaborative filtering. From a managerial perspective, this gives suggestions about the selection of the model to be used depending on the amount of data available. Furthermore, the impact of an enlargement of the customer database on the quality of recommendations is shown. (author's abstract)<br>Series: Working Papers SFB "Adaptive Information Systems and Modelling in Economics and Management Science"
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Gaier, Johanna, Peter Grandits, and Walter Schachermayer. "Asymptotic ruin probabilities and optimal investment." SFB Adaptive Information Systems and Modelling in Economics and Management Science, WU Vienna University of Economics and Business, 2002. http://epub.wu.ac.at/1260/1/document.pdf.
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We study the infinite time ruin probability for an insurance company in the classical Cramér-Lundberg model with finite exponential moments. The additional non-classical feature is that the company is also allowed to invest in some stock market, modeled by geometric Brownian motion. We obtain an exact analogue of the classical estimate for the ruin probability without investment, i.e., an exponential inequality. The exponent is larger than the one obtained without investment, the classical Lundberg adjustment coefficient, and thus one gets a sharper bound on the ruin probability. A surprising result is that the trading strategy yielding the optimal asymptotic decay of the ruin probability simply consists in holding a fixed quantity (which can be explicitly calculated) in the risky asset, independent of the current reserve. This result is in apparent contradiction to the common believe that 'rich' companies should invest more in risky assets than 'poor' ones. The reason for this seemingly paradoxical result is that the minimization of the ruin probability is an extremely conservative optimization criterion, especially for 'rich' companies. (author's abstract)<br>Series: Working Papers SFB "Adaptive Information Systems and Modelling in Economics and Management Science"