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Relevant bibliographies by topics / 13C isotope labeling / Dissertations / Theses

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Dissertations / Theses on the topic '13C isotope labeling'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Ghirardo, Andrea [Verfasser]. "Studies of plant terpenoid biosynthesis using 13C stable isotope labeling techniques (KIT Scientific Reports ; 7583) / Andrea Ghirardo." Karlsruhe : KIT Scientific Publishing, 2011. http://d-nb.info/1185581405/34.

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2

Roy, Chowdhury Taniya. "Tracking Carbon Flow during Methane Oxidation into Methanotrophs using 13C-PLFA Labeling in Pulsing Freshwater Wetlands." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1339084813.

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3

Haynes, Christopher Allen. "Development of an assay for fatty acyl-CoAs using liquid chromatography-electrospray ionization-tandem mass spectrometry and its application to the stable isotope labeling and quantitation of sphingolipid metabolism." Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/37171.

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Fatty acyl-Coenzyme As are metabolites of lipid anabolism and catabolism. A method was developed for their quantitation in extracts of cultured mammalian cells using liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS). Palmitoyl-CoA (C16:0-CoA) is utilized for de novo sphingolipid biosynthesis catalyzed by serine palmitoyltransferase (SPT), which condenses palmitoyl-CoA and serine to form 3-ketosphinganine. After reduction to form sphinganine (Sa), dihydroceramide synthase (CerS) can N-acylate the Sa using a second fatty acyl-CoA molecule, forming dihydrocera

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4

Zhou, Wenxuan. "Stoichiometry and Crystal Structure of Poly (Lactic Acid) (PLA) Stereocomplex (SC) in Cold-crystallization and Solution-grown Crystals as Studied by Solid-state NMR and 13C Isotope Labeling." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1522239647112751.

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5

Campanholi, Diana Ruffato Resende. "Oxidação da galactose utilizando 13C em crianças saudáveis e galactosêmicas." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/17/17144/tde-22042014-101217/.

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A Galactosemia é um erro inato do metabolismo da galactose que ocorre em consequência da deficiência de uma das três principais enzimas envolvidas em seu metabolismo. O tratamento da doença se faz por meio de intervenção dietética. Com a necessidade de melhorar nosso conhecimento acerca do metabolismo da galactose, isótopos estáveis estão sendo usados para mostrar o perfil de oxidação da mesma. O parâmetro bioquímico claramente correlacionado com os resultados clínicos e com o genótipo da GALT é o da oxidação da galactose em dióxido de carbono. A capacidade de determinar a oxidação com adminis

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6

Kheir, Beik Louay. "Dynamics of soil organic matter amino acids : a carbon isotope approach." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0098.

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Cette thèse aborde un point clé du couplage entre ces cycles: la dynamique des molécules azotées (AAs) des matières organiques du sol (MOS). Par des expériences d'incubation, nous avons estimé que les flux de biosynthèse des AAs par les micro-organismes du sol lors du processus de décomposition sont de l'ordre de 25% de la biomasse nouvellement formée. Le profil des AAs individuels biosynthétisés de novo est plus dépendant du type de sol que de la nature du substrat. Dans chaque sol, il est très similaire à celui des AAs des MOS. La biodégradation de matériaux végétaux marqués en 13C a révélé

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7

Olsson, Ulrika. "Structural Studies of O-antigen polysaccharides, Synthesis of 13C-labelled Oligosaccharides and Conformational Analysis thereof, using NMR Spectroscopy." Doctoral thesis, Stockholm University, Department of Organic Chemistry, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7283.

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<p>In order to understand biological processes, to treat and diagnose diseases, find appropriate vaccines and to prevent the outbreak of epidemics, it is essential to obtain more knowledge about carbohydrate structures. This thesis deals with structure and conformation of carbohydrates, analysed by NMR spectroscopy and MD simulations.In the first two papers, the structures of O-antigen polysaccharides (PS) from two different <i>E. coli</i> bacteria were determined using NMR spectroscopy. The O-antigenic PS from <i>E. coli</i> O152 (paper I) consists of branched pentasaccharide repeating units,

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8

Åberg, Ola. "Design and Synthesis of 11C-Labelled Compound Libraries for the Molecular Imaging of EGFr, VEGFr-2, AT1 and AT2 Receptors : Transition-Metal Mediated Carbonylations Using [11C]Carbon Monoxide." Doctoral thesis, Uppsala universitet, Institutionen för biokemi och organisk kemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-98599.

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This work deals with radiochemistry and new approaches to develop novel PET tracers labelled with the radionuclide 11C. Two methods for the synthesis of 11C-labelled acrylamides have been explored. First, [1-11C]-acrylic acid was obtained from a palladium(0)-mediated 11C-carboxylation of acetylene with [11C]carbon monoxide; this could be converted to the corresponding acyl chloride and then combined with benzylamine to form N-benzyl[carbonyl-11C]acrylamide. In the second method, the palladium(0)-mediated carbonylation of vinyl halides with [11C]carbon monoxide was explored. This latter method,

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9

Eriksson, Jonas. "Synthesis of 11C-labelled Alkyl Iodides : Using Non-thermal Plasma and Palladium-mediated Carbonylation Methods." Doctoral thesis, Uppsala universitet, Avdelningen för organisk kemi, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7171.

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Compounds labelled with 11C (β+, t1/2 = 20.4 min) are used in positron emission tomography (PET), which is a quantitative non-invasive molecular imaging technique. It utilizes computerized reconstruction methods to produce time-resolved images of the radioactivity distribution in living subjects. The feasibility of preparing [11C]methyl iodide from [11C]methane and iodine via a single pass through a non-thermal plasma reactor was explored. [11C]Methyl iodide with a specific radioactivity of 412 ± 32 GBq/µmol was obtained in 13 ± 3% decay-corrected radiochemical yield within 6 min via catalytic

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10

Nugue, Guillaume. "Développement de méthodes systémiques pour l'amélioration de la connaissance et du traitement des gliomes." Thesis, Grenoble, 2014. http://www.theses.fr/2014GRENS012/document.

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Es gliomes sont des tumeurs cérébrales associées à une mortalité élevée. Le glioblastome multiforme (GBM) est la forme la plus fréquente des tumeurs cérébrales primaires. Malgré une prise en charge thérapeutique optimale constituée d'une chirurgie, d'une radiochimiothérapie concomitante et d'une chimiothérapie adjuvante, la survie médiane est de 15 mois. Ceci s'explique surtout par le potentiel infiltratif de ces tumeurs. Il est donc difficile de réaliser une exérèse chirurgicale totale, ce qui entraine une récidive quasi-systématique avec l'apparition de chimiorésistance. Ces phénomènes de ré

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11

Michelotti, Alessia. "Développement de méthodes synthétiques pour le marquage au carbone-13 et deutérium de molécules endogènes pour des applications en DNP-IRM et RMN." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLV032.

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L’imagerie par résonance magnétique du 13C (13C-IRM) hyperpolarisée est une technique émergente pour le suivi métabolique in vivo en vue de la détection précoce de cancers. L’optimisation de la sensibilité de la mesure IRM nécessite l’injection de molécules endogènes marquées au carbone-13 et deutérium. Dans ce contexte, le sodium L-[1-13C,U-D] lactate est un agent prometteur pour le diagnostic et le suivi thérapeutique des patients atteints du cancer de la prostate. Pendant cette thèse, la synthèse de cette molécule a été réalisée à partir de la L-[1-13C] alanine. Pour réaliser cette synthèse

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12

Cazenave, Alexandre-Brice. "Réponse adaptative à court terme de la fixation symbiotique du pois protéagineux à une ablation d'une partie des racines nodulées, en lien avec la disponibilité en assimilats carbonés." Thesis, Dijon, 2014. http://www.theses.fr/2014DIJOS018/document.

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La fixation symbiotique d’N par les légumineuses est très sensible aux ravageurs, provoquant des dommages sur les racines nodulées, avec un impact sur la fixation d’N et la croissance qui demeure mal connu. Nous avons alors analysé la réponse adaptative de la fixation symbiotique et de la croissance du pois Frisson sauvage et 3 de ses mutants hypernodulants P64, P118 et P121, respectivement mutés sur les gènes SYM28, SYM29 et NOD3, à une ablation de la moitié du système racinaire, en fin de phase végétative. La réponse adaptative a été mesurée 8 jours après ablation, dans des conditions d'alim

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13

Tsai, Yi Huai, and 蔡逸懷. "Comparative Urine Metabolomics of Renal Cell Carcinoma by 12C/13C-Isotope Dansylation Labeling and Liquid Chromatography/ Mass Spectrometry." Thesis, 2019. http://ndltd.ncl.edu.tw/cgi-bin/gs32/gsweb.cgi/login?o=dnclcdr&s=id=%22107CGU05114025%22.&searchmode=basic.

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14

Silva, Luís André Perpétuo. "NMR Analysis of urinary acetaminophen-glucuronide enrichments from 2H and 13C metabolic tracers in mouse models." Master's thesis, 2020. http://hdl.handle.net/10316/90131.

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Dissertação de Mestrado em Bioquímica apresentada à Faculdade de Ciências e Tecnologia<br>A sociedade contemporânea está repleta de casos de obesidade e diabetes tipo 2, com maior incidência em países desenvolvidos, e a previsão para os próximos anos/décadas não é brilhante. Um dos principais componentes desta epidemia é o consumo de frutose que excede a base evolutiva em que os seres humanos estão inseridos, resultado no metabolismo desequilibrado de hidratos de carbono e lípidos.Aqui propomo-nos a estudar o impacto da frutose no metabolismo hepático, utilizando ratinhos C57BL/6, que são susc

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15

Zhao, Ziwei. "Impact of carbon and nitrogen application in paddy-soil ecosystem: 13,14C labeling, zymography, pH mapping and PLFA." Doctoral thesis, 2020. http://hdl.handle.net/21.11130/00-1735-0000-0005-13BC-2.

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16

Dvořák, Aleš. "Mitochondrie jako cíl protinádorové terapie." Doctoral thesis, 2017. http://www.nusl.cz/ntk/nusl-354538.

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Mitochondrial isocitrate dehydrogenase 2 (IDH2) catalyzes reductive carboxylation (RC, reverse Krebs cycle pathway) and 2HG synthesis (2HG) - metabolite of which many scientists are interested. 2HG may be concurrently synthetized in cytosol by IDH1. RC is involved in anabolic reactions necessary for cell proliferation - produces citrate, fatty acid precursor - especially in hypoxia. IDH2 and IDH1 are not the only enzymes that are involved in 2HG synthesis. Recently, several enzymes, which participate in 2HG production, have been discovered. 2HG is useful in cancer diagnostics due to its overpr

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