Relevant bibliographies by topics / 1444 or 5-1510

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Academic literature on the topic '1444 or 5-1510'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 January 2023

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Journal articles on the topic "1444 or 5-1510"

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Erfiza, N. M., N. R. Purba, K. Ahda, I. Sulaiman, S. Rohaya, and F. Razi. "Characterization of tannin based colorimetric indicator and its application on fish packaging." IOP Conference Series: Earth and Environmental Science 922, no. 1 (November 1, 2021): 012057. http://dx.doi.org/10.1088/1755-1315/922/1/012057.

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Abstract This study aims to determine characteristics of the gel-type colorimetric indicator at various pH and under different storage conditions, then determine the indicator characteristic in the packaging of fish fillets during storage. The gel-type color indicator was synthesized with a concentration of 1%, 3%, and 5% gambir powder. The FT-IR spectra of the color indicator showed the presence of tannin functional groups, namely C=C aromatic rings, C-C phenolic, and C-H groups, respectively at wavenumbers 1517-1519, 1440-1475, and 752-761 1/cm. Moreover, the coefficient value of the Red-Green-Blue (RGB) of the indicator was changed over pH and did not appear to be consistent. Based on the Analysis of Variance (ANOVA) test, the concentration of gambir powder and duration of color indicator storage, respectively, had a significant effect (P <0.05) on the value of the RGB coefficient. The color indicator exposed to sunlight had a smaller RGB coefficient value than the RGB coefficient value of the indicator stored at room temperature and 5-7°C. The application of color indicators with a 1% Gambir powder concentration in fish fillet storage has been tested for 5 days at a temperature of 5-7°C. They showed that the RGB coefficient value of the indicator was proportional to changes in the pH value of fish fillets but not in line with changes in Total Volatile Based Nitrogen (TVBN) of fish fillets.
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Padrielli, L., R. Fanti, A. Ficarra, L. Gregorini, F. Mantovani, and S. Spangler. "The Low Frequency Variability of Extragalactic Radio Sources: A Relativistic Effect or Galactic Scintillation?" Symposium - International Astronomical Union 129 (1988): 297–98. http://dx.doi.org/10.1017/s0074180900134758.

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Results obtained on the Low Frequency Variability (LFV) phenomenon, by means of combined multifrequency observations of 50 sources, on a period of more than ten years on a frequency grid of 0.4, 2.3, 4.8, 8.0, and 14.4 GHz and two epoch VLBI observations at 18 cm can be summarized as follows: 1.15–20% of variables appear to have variations consisting either of quasi-simultaneous outbursts at all frequencies or of bursts which drift to lower frequencies with time and decreasing amplitude. In our sample, we find five good cases: 3C 120, 0605-085, 1510-089, 3C 345, BL Lac. Three of these are famous superluminals; the other two show significant structural changes between our 18 cm VLBI measurements. The corresponding expansion rate for these five sources is in agreement with the γ's derived from LFV with the usual causality arguments. For the sources of this class, the observations are therefore in agreement with models that explain the phenomenon of the variability as synchrotron emission of relativistic electrons beamed in a direction close to the line of sight.2.35% of variables show only low frequency (<1 GHz) variability and little or no intermediate high frequency variations. In DA 406, prototype of the category, no superluminal motions have been observed, even if the resolution of our VLBI observations should allow the detection of the structural change expected on the basis of intrinsic LFV. In this case we do not find direct evidence of relativistic motions associated with the LFV and the process is most easily explained if the variations are extrinsic (propagation effects through the interstellar medium as the slow refractive scintillation).3.The remaining 40–45% of variables show uncorrelated high (<5 GHz) and low frequency variability with a minimum of activity at the intermediate frequencies. The explanation of the phenomenon is less clear. It could be attributed to intrinsic (superluminal) variations at high frequencies, coexisting with unrelated processes at low frequencies.
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Kim, William, and Torunn Sivesind. "Patient Perceptions of Dermatologic Photography: Scoping Review." JMIR Dermatology 5, no. 1 (January 26, 2022): e33361. http://dx.doi.org/10.2196/33361.

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Background Medical photography is used extensively in dermatology to record disease progression, measure treatment response, and help teach patients about skin disease; such photos are also commonly utilized in teledermatology, medical education, research, and medical reference websites. Understanding patient perceptions of medical photographs obtained during dermatologic care in the clinic or hospital setting is critical to enable the delivery of high-quality, patient-centered medical care. Objective The aims of this study were to elucidate patient perceptions of skin photos in dermatology and to explore possible next steps in improving the patient experience with medical photography in the hospital or clinic setting. Methods A scoping review of the literature was performed using the PubMed database, with clinic- or hospital-based full-text publications in English spanning the last 10 years considered for inclusion. Results The majority of included studies (10/11, 91%) found positive patient attitudes toward medical photographs. The majority of patients (1197/1511, 79.2%) felt that medical photographs could improve medical care in the clinic setting. Written consent detailing all photo uses, including secondary uses (such as research or teaching), was preferred, apart from in 1 study. Patients preferred or found it acceptable for the photographer of their medical photos to be a physician (1301/1444, 90.1%). Clinic-owned cameras with departmental record storage were the preferred modality. Latinx and African American patients expressed less trust in the utility of medical photographs to improve care, compared with Asian and White patients. The minimal number of available publications on this topic and the inclusion of articles older than 5 years are limitations, since patient perceptions of medical photography may have rapidly changed during this time span, particularly in light of the COVID-19 pandemic and the subsequent increase in teledermatology visits. Conclusions Patients reported positive perceptions of dermatologic photography for improving their medical care. Ethnic disparities in patient perceptions require further exploration to better elucidate nuances and develop interventions to improve the experience of marginalized patients. Building patient trust in nonphysician photographers may enhance clinic efficiency. Although clinic-owned cameras are well-accepted by patients, improved patient education surrounding the safety of electronic medical record phone applications is needed.
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Mundt, Lothar. "VEIT PROBST: Petrus Antonius de Clapis (ca. 1440-1512). Ein italienischer Humanist im Dienste Friedrich des Siegreichen von der Pfalz. - Paderborn, München, Wien, Zürich: Schöningh 1989 (=Veröffentlichungen des Historischen Instituts der Universität Mannheim. 10.) 5 Bll., 291 S." Daphnis 20, no. 3-4 (March 30, 1991): 753–55. http://dx.doi.org/10.1163/18796583-90000522.

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5

Hough, Rachael E., Clare Rowntree, Rachel Wade, Nicholas Goulden, Chris Mitchell, and Ajay J. Vora. "Impact Of Age On Toxicity Associated With Chemotherapy For Acute Lymphoblastic Leukaemia (ALL): Results From The UK Prospective Study UKALL2003." Blood 122, no. 21 (November 15, 2013): 840. http://dx.doi.org/10.1182/blood.v122.21.840.840.

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Abstract Despite the substantial improvements made in the outcomes of paediatric ALL, with ‘cure' rates now in excess of 90%, survival in teenage and young adult (TYA) patients has remained inferior. The reasons for this are likely multifactorial, including tumour biology, toxicity, compliance, access to clinical trials and protocol (adult or paediatric) used. We report the toxicity profiles observed in children, teenagers and young adults treated on the UK intensive, minimal residual disease (MRD) directed ALL protocol, UKALL2003. Of a total of 3126 patients treated, 1520 patients were under 5 years old, 767 were aged 5-9 years, 610 aged 10-15 years and 229 aged 16-24 years, with a median overall follow-up of 4 year and 10 months. The risk of serious adverse events (SAEs) was higher in patients older than 10 years (56% in 10-15 year olds, 53% in 16-24 year olds) compared to those aged 9 or younger (30% in under 5 years and 31% in 5-9 years)(p<0.0001), with no difference in the those aged 16-24 compared to younger teenagers (p=0.5). The incidence (per number of patients in each group) and distribution of toxicities according to age group is summarised in the table.Table 1Age in years<55-910-1516-24AllTotal number of patients1520767610229 NB: 56 pts≥20 years3126Infection n (%)328 (21.6%)130 (17.0%)145 (23.8%)72 (31.4%)675 (21.6%)Asaparaginase n (%)57 (3.8%)57 (7.4%)64 (10.5%)31 (13.5%)209 (6.7%)Methotrexate n (%)100 (6.6%)74 (9.6%)123 (20.2%)33 (14.4%)330 (10.6%)Steroid n (%)54 (3.6%)37 (4.8%)141 (23.1%)52 (22.7%)284 (9.0%)Vincristine n (%)34 (2.2%)11 (1.4%)22 (3.6%)7 (3.0%)74 (2.4%)Other SAEs94 (6.2%)42 (5.5%)90 (14.8%)25 (10.9%)251 (8.0%) The incidence of certain toxicities including viral infection (5.3%), asparaginase hypersensitivity (1.9%) and vincristine neurotoxicity (2.1%) appeared equivalent across all age groups. Avacular necrosis was seen predominantly in adolescents (83% of 147 events in 10-19 year olds) and was rare in those younger than 10 years (n=18) or older than 20 years (n=7). Asparaginase thrombotic events increased in frequency with increasing age (1.5% in under 5 years, 3.3% in 5-9 years, 4.4% in 10-15 years and 8.3% in 16-24 year olds)(p<0.0001). All other toxicities were more frequently observed in over 10 year olds compared to patients aged 9 or younger, with no difference between 16-24 year olds and 10-15 year olds. The impact of age on SAEs associated with intensive ALL chemotherapy varies according to specific toxicities. In general, toxicity is higher in those over 10 years compared to younger patients, with no excess toxicity in those aged 16-24 compared to 10-15 years. However, specific toxicities may increase with increasing age (thrombosis), be restricted to adolescence (AVN) or be unrelated to age (vincristine neurotoxicity, asparaginase hypersensitivity). Disclosures: No relevant conflicts of interest to declare.
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Kroschinsky, Frank P., Kai Friedrichsen, Juliane Mueller, Mathias Haenel, Gerhard Ehninger, and Eberhard Schleyer. "Oral Etoposide Is Equivalent to Intravenous Administration within the CHOEP-Regimen - Results of a Comparative Pharmacokinetic Study." Blood 108, no. 11 (November 16, 2006): 4662. http://dx.doi.org/10.1182/blood.v108.11.4662.4662.

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Abstract The addition of etoposide to the CHOP protocol (CHOEP) has been shown to improve outcome particularly in younger patients (<60 years) with aggressive non-Hodgkin’s lymphoma [Pfreundschuh, Blood 2004]. In the previous trials a dose of 100 mg/m2 etoposide was given intravenously on three consecutive days representing a disadvantage of CHOEP compared to standard CHOP in terms of patients’ convenience. Therefore we investigated the pharmacokinetic equivalency of etoposide as an oral preparation on days 2 and 3 compared to the intravenous route. Ten patients (male, n=7; female, n=3; median age 56 years) with aggressive B-cell- (n=9) or T-cell- (n=1) lymphoma were included. The CHOEP regimen consisted of cyclophosphamide 750 mg/m2, doxorubicin 50 mg/m2, vincristine 2 mg/m2 and prednisone 100 mg orally days 1 to 5. Etoposide 100 mg/m2 was given intravenously on day 1, and 200 mg/m2 orally on days 3 and 4, respectively. EDTA blood for pharmacokinetic study were taken on days 1 (i.v. study) and 3 (p.o. study) before etoposide and after administration at 30, 60 and 90 min, every hour until 8 hours, followed by samplings at 16, 20, 24 and 48 hours. The samples were centrifuged immediately at 5°C for 15 min, and the plasma was aliquoted into cryo vials and stored at −20°C until assayed. Etoposide levels in plasma were determined by high-performance liquid chromatography (HPLC). The area under the plasma etoposide concentration versus time curve (AUC), plasma etoposide clearance (CL), volume of distribution in steady state (VDss) and terminal etoposide plasma half-life (t½) for the intravenous and oral administered drug were calculated based on the TOPFIT computer program. The median bioavailability after oral etoposide was 58 % with an interpatient variation (coefficient of variation, CV) of 26 %. AUC was very similar after 200 mg/m2 oral etoposide and intravenous administration of 100 mg/m2 of the drug, however the pharmacokinetic variation was higher after oral uptake compared to the parenteral route (35 % vs. 23 %). Data are presented in detail (medians and ranges) in Table #1. We conclude that, within the CHOEP regimen, the intravenous administration of 100 mg/m2 etoposide on days 2 and 3 can be replaced by 200 mg/m2 of the oral preparation, which simplifies the treatment in the outpatient setting. Table #1 100 mg/m2 Etoposide i.v. 200 mg/m2 Etoposide p.o. C max [μg/ml] 16.7 (10.1 – 21.1) 13.4 (5.8 – 16.8) V ss [L] 14.4 (10.7 – 18.3) 15.1 (10.6 – 25.4) CL total [ml/min] 45.9 (29.6 – 62.8) 82.5 (45.5 – 151.0) CL renal [ml/min] 17.2 (9.4 – 52.6) 16.3 (4.7 – 39.7) t 1/2 [h] 4.1 (3.8 – 5.4) 5.8 (3.2 – 8.3) AUC [μg × h/ml] 72.5 (44.3 – 93.4) 81.6 (44.0 – 147.0)
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Nakamoto, Yoshihiko, Megumi Ishiguro, Motoki Yoshida, Koji Ikejiri, Izumi Mochizuki, Hidetaka Mochizuki, Kenjiro Kotake, et al. "Noninferiority of S-1 to UFT/LV as adjuvant chemotherapy for stage III colon cancer: A randomized phase III trial (ACTS-CC)." Journal of Clinical Oncology 31, no. 15_suppl (May 20, 2013): 3518. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.3518.

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3518 Background: The ACTS-CC trial is a phase III trial designed to validate non-inferiority of S-1 to UFT/LV, a standard treatment in Japan as adjuvant chemotherapy for stage III colon cancer. This is the first report which evaluated the efficacy of S-1 as adjuvant therapy for colon cancer. Methods: 20-80 aged patients with stage III colon cancer who underwent curative surgery were randomly assigned to receive S-1 (80, 100, or 120 mg/day according to BSA on days 1 to 28, followed by 14 days rest, 4 courses) or UFT/LV (UFT: 300 to 600 mg/day according to BSA and, LV: 75 mg/day on days 1 to 28, followed by 7 days rest, 5 courses). Primary endpoint was DFS. Sample size was 1,480 determined with one-sided alpha of 0.05, power of 0.80, and non-inferiority margin of hazard ratio (HR) of 1.29. Results: Among 1535 enrolled patients between Apr. 2009 and Jun. 2010, 1518 patients (758 in S-1 group, 760 in UFT/LV group) were included in the efficacy analysis. Median follow-up was 41.3 months, the mean age at enrollment was 64.5 years, wide lymph node dissection (D3) was done in 79.8%, the median number of dissected lymph nodes was 17, and stage IIIA/IIIB/IIIC were 15%/71%/14%. The 3-year DFS rate was 75.5% in S-1 group and 72.5% in UFT/LV group. The HR of DFS was 0.85 (95%CI: 0.70-1.03) and non-inferiority of S-1 was demonstrated (p<0.0001). The completion rate of the protocol treatment was 76.5% in S-1 group and 72.5% in UFT/LV group. The overall incidence of grade ≥3 adverse events (AEs) in S-1 group and UFT/LV group were 16.0% and 14.4%: 4.4% and 5.5% for diarrhea, 4.9% and 3.5% for anorexia, 0.7% and 0.4% for leucopenia, 0.9% and 0.1% for anemia, 0.1% and 0.4% for thrombocytopenia, 1.2% and 1.5% for hyperbilirubinemia, 0.8% and 2.1% for AST elevation, and 1.1% and 3.3% for ALT elevation, respectively. Conclusions: Adjuvant therapy of S-1 for stage III colon cancer was demonstrated to be non-inferior in DFS to that of UFT/LV. Although AE profiles differed between S-1 group and UFT/LV group in this trial, incidence and degree of AEs were acceptable, and the completion rate of the protocol treatment was high. Adjuvant chemotherapy using S-1 will be a treatment option for stage III colon cancer. Clinical trial information: NCT00660894.
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Lu, C. H., T. J. Lee, C. L. Yu, and S. C. Hsieh. "POS1386 THE OCCURRENCE OF INFUSION-RELATED REACTIONS TO RITUXIMAB IS ASSOCIATED WITH LOW PLASMA LEVELS OF MYELOPEROXIDASE-DNA COMPLEXES." Annals of the Rheumatic Diseases 81, Suppl 1 (May 23, 2022): 1033.1–1033. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1626.

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BackgroundRituximab (RTX), a chimeric anti-CD20 antibody, is used in the treatment of rheumatic diseases. Infusion-related reactions (IRRs) are the most common adverse event, and premedication may reduce the incidence [1]. To date, there is still no effective predictor for the occurrence of IRRs.ObjectivesTo identify factors predicting the occurrence of IRRs during the first course of RTX therapy in patients with rheumatic diseases.MethodsWe prospectively enrolled 29 patients with rheumatic diseases underwent the first course of RTX infusion, which consisted of two 500-mg intravenous infusions separated by about 2 weeks. Each patient received 100 mg intravenous methylprednisolone 60 minutes prior to each RTX infusion. Complete blood counts and C-reactive protein tests were performed before each infusion. The plasma levels of IL-1β, IL-6, IL-8, TNF-α, B-cell activating factor (BAFF) and plasma levels of myeloperoxidase (MPO)-DNA complexes were measured. All-grade IRRs occurring within 24 hours after infusions were recorded. Mann-Whitney U test was conducted to analyze factors associated with IRRs.ResultsThe demographics and characteristics of the patients were shown in Table 1. Two patients reported IRRs in the first infusion, and three patients had IRRs in the second infusion of the first course. Among the five IRRs, four were skin rashes and one was headache. No serious events were found. A significant association between the low levels of MPO-DNA complexes and IRRs in the second infusion was noted (p = 0.011). The low plasma levels of MPO-DNA complexes also tended to be associated with the occurrence of IRR in the first infusion. The IRRs were not significantly correlate with absolute neutrophil counts, absolute lymphocyte counts, and the plasma levels of IL-1β, IL-6, IL-8, TNF-α, and BAFF.Table 1.The characteristics of the patients received the first course of RTX treatment (n = 29).Age (years)‡44.9 (38.4 to 50.9)Gender, female (%)26 (89.7)Diagnosis Antiphospholipid syndrome, n (%)11 (37.9) Autoimmune thyroid disease, n (%)6 (20.7) Sjögren’s syndrome, n (%)4 (13.8) Systemic lupus erythematosus, n (%)2 (6.9) Rheumatoid arthritis, n (%)1 (3.4) Others, n (%)#5 (17.2)Blood test during each infusionBefore first infusionBefore second infusion MPO-DNA complexes levels‡¶11% (3% to 53%)15% (3% to 32%) IL-6 (pg/mL)‡8.3 (6.9 to 11.2)12.1 (8.5 to 13.8) IL-8 (pg/mL)‡14.4 (12.6 to 15.9)13.0 (12.1 to 14.9) TNF-α (pg/mL)‡8.9 (6.9 to 12.7)8.1 (6.1 to 11.2) BAFF (pg/mL)‡155.1 (121.3 to 231.9)276.8 (201.3 to 331.2) IL-6 (pg/mL)‡8.3 (6.9 to 11.2)12.1 (8.5 to 13.8) Absolute neutrophil count (/μL) ‡4380 (3441 to 5890)4360 (3286 to 8195) Absolute lymphocyte count (/μL) ‡1511 (1198 to 1799)1214 (854 to 1465) C-reactive protein (mg/dL) ‡0.03 (0.01 to 0.10)0.04 (0.02 to 0.21)‡ Data are presented in median and interquartile range.# Other diagnoses include systemic sclerosis, dermatomyositis, vasculitis, pemphigus, myasthenia gravis.¶ Data are presented in ratio to positive control.ConclusionPlasma MPO-DNA complexes represent neutrophil extracellular traps released by activated neutrophils. Neutrophils could be involved in the response to RTX therapy [2]. In this study, the risk of IRRs to RTX tended to increase when the plasma level of MPO-DNA complexes is low. Further research is needed to clarify the impact of activated neutrophils on RTX therapy.References[1]Paul F, Cartron G. Infusion-related reactions to rituximab: frequency, mechanisms and predictors. Expert Rev Clin Immunol. 2019 Apr; 15(4):383-389.[2]Taylor RP, Lindorfer MA. Fcγ-receptor-mediated trogocytosis impacts mAb-based therapies: historical precedence and recent developments. Blood. 2015 Jan 29; 125(5):762-766.AcknowledgementsThis work was supported by the Ministry of Science and Technology (National Science Council) of Taiwan (Grant No. 109-2314-B-002-234 and 110-2314-B-002-244).Disclosure of InterestsNone declared
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Lee, Hun Ju, Susan O'Brien, Hagop M. Kantarjian, Farhad Ravandi, Stefan Faderl, Charles Koller, Marina Konopleva, et al. "Outcome of Patients with Philadelphia Chromosome-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL) with Relapse After Tyrosine Kinase Inhibitor (TKI) Therapy." Blood 118, no. 21 (November 18, 2011): 1518. http://dx.doi.org/10.1182/blood.v118.21.1518.1518.

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Abstract Abstract 1518 Background: Treatment with TKIs has greatly improved the outcome of patients with Ph+ ALL. However, many patients treated with TKI-based therapy eventually have a relapse. The response to salvage therapy and long-term outcomes of these patients are unknown. Aims: Describe the outcomes of patients with Ph+ ALL with resistance to or relapse after frontline TKI-based chemotherapy. Methods: We analyzed the outcome of patients who were treated in clinical trials at our institution between February 2001 and July 2008 with TKI-based chemotherapy for newly diagnosed Ph+ ALL who had refractory or relapsed disease. Results: One hundred thirteen patients were treated with frontline hyperfractionated cyclophosphamide, doxorubicin, vincristine, and dexamethasone (HCVAD) plus imatinib (HCVAD+I; n=54) or HCVAD plus dasatinib (HCVAD+D; n=59). Of these, 35 (31%) experienced primary resistance (n=1) or relapse (n=34). The median age was 51 years [range (r): 20–85]; 12 patients (34%) were older than 60 years. Median follow-up was 21.1 mo (r: 4.2–56.7). Median white blood cell and platelet counts at diagnosis were 14.4 × 109/L (r: 1.2–292.9) and 48 × 109/L (r: 4–425), respectively. White blood cell count was >30 × 109/L in 13 patients (37%). Median peripheral and bone marrow blast percentages were 53% (r: 0–97%) and 80% (r: 1–98%), respectively. Twenty-two patients (63%) had received HCVAD+I and 13 (37%) HCVAD+D. Twenty-three patients (66%) had experienced first complete remission (CR1) with 1 cycle of induction. Median CR1 duration was 12 mo (r: 1.9–42). Four patients underwent allogeneic stem cell transplantation (ASCT) in CR1. ABL kinase domain mutations were investigated in 28 patients (80%) at relapse; 16 (57%) had mutations, including 5 (14%) with T315I (all had received HCVAD+D). Upon relapse, 31 patients received first salvage therapy (S1), 24 with chemotherapy [HCVAD+D, n=8; HCVAD+I, n=3; HCVAD+nilotinib (N), n=1; HCVAD+asparaginase (Asp), n=1; methotrexate, vincristine, Asp, and dexamethasone (MOAD), n=2; others, n=9]; 6 with a TKI only (I, n=2; D, n=1; N, n=1; others, n=2); and 1 with ASCT. Three patients were unfit for treatment. Median cycles of S1 were 2 (r: 1–8). Thirteen patients (42%) had second complete remission (CR2) (HCVAD+D, n=6; HCVAD+I, n=2; HCVAD+N, n=1; HCVAD+Asp, n=1; others, n=3). Median time to CR2 was 1.5 mo (r: 0.7–8.8). Five patients underwent ASCT in CR2. Median CR2 duration was 7.3 mo (r: 1.4–36.2). Complete cytogenetic response was seen in 11 patients (35%); major molecular response (BCR-ABL/ABL ratio <0.05%) in 9 (29%); and complete molecular response in 7 (22%); and complete hematologic response in 15 (48%). Times to complete cytogenetic response and complete molecular response were 1.3 mo (r: 0.7–10.6) and 3 mo (r: 1.5–8.7), respectively. Seven patients had second relapse. Fifteen patients (7 relapse, 8 refractory) received second salvage therapy (S2) with systemic chemotherapy (MOAD, n=2; phase I/single-agent TKI, n=8; others, n=5); 1 patient had solitary central nervous system (CNS) relapse treated with intrathecal cytarabine and methotrexate. CR3 was obtained in 1 patient, the patient with sole CNS relapse. Median disease-free survival (DFS) and overall survival (OS) after S1 were 6.5 mo (r: 0.5–45) and 7.3 mo (r: 1.4–36.2), respectively. At last follow-up, 2 patients (6%) were alive and 33 had died, 11 (33%) of infectious complications, 5 (15%) of organ failure, 3 (9%) of bleeding complications, 2 (6%) of graft-versus-host disease complications, 2 (6%) of CNS relapse, and 10 (30%) of other or unknown causes. Median OS after S2 was 2.1 mo (r: 1.4–2.6). In univariate analysis, age >60 years was associated with worse OS after S1 [4.2 vs. 12.7 mo; 95% confidence interval (CI) 1.8 to 6.7 vs. 7.5 to 17.9 (P=0.006)]. Complete hematologic response was associated with improved OS after S1 [15.4 vs. 4.3 mo; 95% CI 9.1 to 21.8 vs. 2.5 to 6.0 (P<0.001)]. Major molecular response was associated with improved OS after S1 [18.1 vs. 5.7 mo; 95% CI 9.3 to 26.8 vs. 3.6 to 7.8 (P=0.003)]. Choice of prior TKI (HCVAD+I vs. HCVAD+D) did not significantly influence CR and OS after relapse. Conclusion: Patients with refractory or relapsed Ph+ ALL after TKI-based therapy have poor outcome, particularly those who are older or have persistent BCR/ABL transcripts. New agents are needed to improve the outcome in this population. Disclosures: Kantarjian: BMS: Research Funding. Ravandi:Bristol Myers Squibb: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding; Novartis: Honoraria. Cortes:Chemgenex: Membership on an entity's Board of Directors or advisory committees, Research Funding; Ariad: Membership on an entity's Board of Directors or advisory committees, Research Funding; Pfizer: Membership on an entity's Board of Directors or advisory committees, Research Funding; Bristol-Myers Squibb: Membership on an entity's Board of Directors or advisory committees, Research Funding; Novartis: Membership on an entity's Board of Directors or advisory committees, Research Funding.
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Demetrio, D., A. Magalhaes, M. Oliveira, R. Santos, and R. Chebel. "11 Invivo-derived embryo pregnancy rates at Maddox Dairy from 2008 to 2018." Reproduction, Fertility and Development 32, no. 2 (2020): 130. http://dx.doi.org/10.1071/rdv32n2ab11.

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Maddox Dairy, located in Riverdale, CA, USA, is a Holstein herd that milks 3500 cows with a 305-day mature-equivalent milk production of 12 800 kg, and they have been producing high genetic animals by embryo transfer (ET) since the early 1980s. Invivo-derived embryos from Holstein donors were transferred fresh (grade 1 or 2) or frozen (grade 1), at morula (4), early blastocyst (5), or blastocyst (6) stage, to virgin heifers (VH, natural oestrus, 13-15 months old) or lactating cows (LC, Presynch-Ovsynch, 86 days in milk, first or second lactation) 6 to 9 days after oestrus. Pregnancy diagnosis was done by transrectal ultrasonography at 32-46 days in VH and by the IDEXX PAG test at 30 days in LC. June, July, August, September, and October were called critical months (first service AI conception rate drops below 44%) and compared with the other months. The data from 32 503 ETs between January 2008 and December 2018 are summarised on Table 1. Pregnancy rates (PR) are lower for LC recipients than for VH. Embryo transfers performed 7 or 8 days after oestrus had higher PR in both types of recipients and embryos, but Day 6 and 9 oestrus are also used with fair results. The season does not seem to affect PR. There is not enough difference in the combination of stage and days from oestrus for invivo-derived embryos. These numbers do not belong to a planned experiment. Several management changes during the years were made, which make it very difficult to apply statistical methods to analyse the data correctly. They are used as a tool to make decisions in an attempt to improve future results. Table 1.Pregnancy rate (PR) of virgin heifers (top) and lactating cows (bottom)-fresh (SH) and frozen (OZ) invivo-derived embryo transfer1 Heat-months SH-ST4 SH-ST5 SH-ST6 SH-All OZ-ST4 OZ-ST5 OZ-ST6 OZ-All PR% n PR% n PR% n PR% n PR% n PR% n PR% n PR% n Heifers 6 d-CM 62 934 66 243 68 69 63 1246 56 473 58 219 62 42 57 734 6 d-OM 62 1623 67 489 69 211 64 2323 56 600 55 296 48 137 55 1033 6 d-T 62 2557 67 732 69 280 63 3569 56 1073 57 515 51 179 56 1767 7 d-CM 64 1506 68 495 67 221 65 2222 60 822 62 340 63 156 61 1318 7 d-OM 66 2723 68 1021 69 510 67 4254 57 1120 59 581 57 231 58 1932 7 d-T 66 4229 68 1516 69 731 67 6476 58 1942 60 921 60 387 59 3250 8 d-CM 65 1348 64 518 67 322 65 2188 59 595 64 258 63 108 61 961 8 d-OM 66 2166 68 886 70 510 67 3562 61 770 60 364 51 130 60 1264 8 d-T 66 3514 67 1404 69 832 66 5750 60 1365 62 622 56 238 60 2225 9 d-CM 60 109 56 43 70 20 60 172 60 5 33 6 50 4 47 15 9 d-OM 58 129 63 57 60 40 60 226 63 16 50 18 75 4 58 38 9 d-T 59 238 60 100 63 60 60 398 62 21 46 24 63 8 55 53 All-CM 64 3897 66 1299 67 632 65 5828 58 1895 61 823 63 310 60 3028 All-OM 65 6641 67 2453 69 1271 66 10 365 58 2506 58 1259 53 502 58 4267 All-T 65 10 538 67 3752 69 1903 66 16 193 58 4401 60 2082 57 812 59 7295 Lactating cows 6 d-CM 54 265 48 86 50 12 53 363 38 141 31 77 50 10 36 228 6 d-OM 49 463 52 203 45 56 50 723 46 101 48 54 59 27 48 182 6 d-T 51 728 51 289 46 68 51 1086 41 242 38 131 57 37 42 410 7 d-CM 54 755 59 274 56 103 55 1137 43 928 48 450 43 192 45 1570 7 d-OM 55 914 66 367 54 109 58 1393 46 1052 45 564 47 353 46 1969 7 d-T 55 1669 63 641 55 212 57 2530 45 1980 46 1014 46 545 45 3539 8 d-CM 63 252 68 82 76 33 65 368 48 219 56 80 42 33 50 332 8 d-OM 61 257 64 161 53 47 61 466 50 191 53 77 56 16 51 284 8 d-T 62 509 65 243 63 80 63 834 49 410 55 157 47 49 50 616 All-CM 56 1272 58 442 60 148 57 1868 44 1288 47 607 43 235 45 2130 All-OM 55 1634 62 731 51 212 56 2582 47 1344 46 695 48 396 47 2435 All-T 55 2906 60 1173 55 360 57 4450 45 2632 47 1302 46 631 46 4565 1ST=stage; CM=critical months (June, July, August, September, and October); OM=other months.
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Dissertations / Theses on the topic "1444 or 5-1510"

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Mendonça, Débora Barbam [UNESP]. "Botticelli: pintura e teoria." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/93137.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Trata-se de uma investigação dos aspectos filosóficos que envolviam o fazer artístico de Botticelli; tomando como cenário a cidade de Florença durante o Quattrocento. Este trabalho se realizou a partir de uma dupla abordagem, envolvendo um debate filosófico e historiográfico, cuja finalidade foi a de apresentar as discussões teóricas que permeavam a atividade dos artistas da época. Nosso trabalho contou com um aparato histórico, para que fosse possível configurar o Renascimento a partir do contexto em que as atividades culturais estiveram inseridas. Dentre as teorias distintas que visavam refletir sobre uma questão comum, o belo artístico, ressaltamos a proposta neoplatônica de Marsilio Ficino e a teoria pautada no cientificismo humanista de Leon Batista Alberti. A finalidade do embasamento teórico era de indicar aos artistas como deveria ser a composição de suas obras, como deveriam ser as apropriações a partir da Antiguidade, e, desta maneira, mostra como localizar a beleza dada pela natureza. Procuramos em nosso trabalho identificar o pintor Sandro Botticelli como exemplo legítimo da busca pela beleza artística, pela graça que resultava da reflexão sobre a arte como imitação eletiva da natureza
This thesis is an investigation on the philosophical aspects involved in Botticelli’s painting, adopting Florence during the Quattrocento as the main scenario. This work has been done from a double approach, involving a historical debate and a philosophical one, which aims at showing theoretical discussions, that underlies the activity of artists of this period. The historical apparatus of our work allowed us to configure the Renaissance from the context in such cultural activities were inserted. Among the distinct theories that aim to think about the artistic beauty, we highlighted Marcelo Ficino’s Neo-platonic proposal and the theory based on Leon Batista Alberti’s Humanist Scientific. The goal of this theoretic foundation was to indicate how should be the composition of works made by artists and how should be the appropriation of Ancient by them, what, thus, implies at showing how we can locate beauty given by nature. We seek in our work to identify Sandro Botticelli as a genuine example of the questing for artistic beauty, for grace which results of reflection about art as elective imitation of nature
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Lake, G. Thomas. "The five paintings of the Adoration of the Magi by Sandro Botticelli /." Thesis, McGill University, 1986. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61261.

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The thematic unit formed by the five versions of The Adoration of the Magi painted by Sandro Botticelli provide a special opportunity for studying his artistic development. An investigation of these five paintings shows that Botticelli aimed toward a goal of perfecting compositional techniques. He systematically made alterations to these works in order to create special point of view effects.
This thesis outlines the general trends in art with respect to the Adoration theme and then concentrates on a demonstration of Botticelli's attempts at correlating compositional devices and the unique features developed with respect to spectator involvement. This selected study allows for a careful examination which spans the artistic career of Sandro Botticelli. As a result, it can be shown that it was perhaps Botticelli, rather than Leonardo da Vinci, who was primarily responsible for the development of a compositional format which became a foundation stone of High Renaissance compositions.
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Vermeersch, Paula. "Considerações sobre os desenhos de Sandro Botticelli para a Divina Comedia." [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/270062.

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Orientador: Marcio Seligmann-Silva
Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Estudos da Linguagem
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Resumo: A tese aborda alguns aspectos dos desenhos que o pintor florentino Alessandro di Marianni di Vanni Filipepi, dito Sandro Botticelli (1445-1510), realizou, em data incerta entre 1480 e 1500, para a ilustração da Divina Comédia de Dante Alighieri (1265-1321). Tais desenhos, feitos sobre pergaminho, foram separados durante séculos e sempre muito pouco se soube a seu respeito. Eles formam, ademais, o cerne de uma série de reflexões sobre o papel das artes figurativas no chamado Renascimento italiano, as quais envolvem as seguintes temáticas: a relação entre palavra e imagem; a presença de um diálogo com a tradição anterior de manuscritos ilustrados para o poema de Dante; o debate entre os comentadores da Comédia e a intersecção de projetos intelectuais, nas cidades italianas de fins do Quattrocento, sobre a recepção e compreensão do legado de Dante, como é o caso da primeira edição do Comento Sopra La Comedia, de 1481, do humanista Cristoforo Landino (1425-1498), e os incunábulos e as edições posteriores; e a visão de que, mais do que ilustrador, Botticelli também foi um comentador da Comédia, a partir de análises de algumas iconografias de seus desenhos
Abstract: The present thesis deals with some aspects of the drawings that the Florentine Alessandro di Marianni di Vanni Filipepi, alias Sandro Botticelli (1445-1510), did, in uncertain date between 1480 and 1500, to illustrate the Divine Comedy of Dante Alighieri (1265-1321). Such drawings, which were made on parchment, were separated through centuries and always very little was known about them. They form, moreover, the center of a series of reflections on the role of the figurative arts at the so-called Italian Renaissance, which encompasses the following subjects: the relationship between word and image; the presence of a dialogue with the previous tradition of illustrated manuscripts for Dante¿s poem; the debate among the commentators of the Comedy and the intersection of intellectual projects, in the Italian cities at the end of the Quattrocento, on the reception and understanding of Dante¿s legacy, as is the case of the first edition of the Comento Sopra La Comedia, from 1481, of the humanist Cristoforo Landino (1425-1498), and the incunabula and the subsequent editions; and the vision that, more than being an illustrator, Botticelli was also a commentator of the Comedy, which can be deduced from the analyses of some of the iconographies of his drawings
Doutorado
Literatura e Outras Produções Culturais
Doutor em Teoria e História Literária
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Taylor, Chloë. "The aesthetics of sadism and masochism in Italian renaissance painting /." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79810.

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This thesis analyses selected paintings and aspects of life of the Italian Renaissance in terms of the aesthetic properties of sadistic and masochistic symptomatologies and creative production, as these have been explored by philosophers such as Michel Foucault, Roland Barthes, Marcel Henaff, and Gilles Deleuze. One question which arises from this analysis, and is considered in this thesis, is of the relation between sexual perversion and history, and in particular between experiences of violence, (dis)pleasure and desire, and historically specific forms of discourse and power, such as legislation on rape; myths and practices concerning marriage alliance; the depiction of such myths and practices in art; religion; and family structures. A second question which this thesis explores is the manners in which sadistic and masochistic artistic production function politically, to bolster pre-existing gender ideologies or to subvert them. Finally, this thesis considers the relation between sadism and masochism and visuality, both by bringing literary models of perversion to an interpretation of paintings, and by exploring the amenability of different genres of visual art to sadism and masochism respectively.
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Books on the topic "1444 or 5-1510"

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Deimling, Barbara. Sandro Botticelli 1444/5-1510. Koln: Benedikt Taschen Verlag, 1994.

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Tilman, Lingesleben, ed. Alessandro Botticelli 1444/45-1510. Köln: Könemann, 1998.

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Botticelli. Antella, Florence, Italy: Scala, 1994.

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Botticelli, Sandro, 1444 or 5-1510., ed. Botticelli's Neoplatonic images. Potomac, Md., U.S.A: Scripta Humanistica, 1993.

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Santi, Bruno. Botticelli. Little, Brown Book Group Limited, 1991.

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Botticelli, Sandro, and Liana Cheney. Botticelli's Neoplatonic Images (Scripta Humanistica). Scripta Humanistica, 1985.

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Botticelli, Sandro, and Bruno Santi. Botticelli (The Library of Great Masters). Riverside Book Company, 1991.

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Gromling, Alexandra, and Tilman Lingesleben. Botticelli (Masters of Italian Art). Konemann, 1999.

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Book chapters on the topic "1444 or 5-1510"

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"WINCHESTER COLLEGE 49 1501 (3 pieces 10 1/4 yds.), 1503 (3 pieces 12 yds.), 1507–09 (3 pieces 4 yds.) and 1510 and 1514–16 (3 pieces 8 yds.), and price rises above 53.33s. per piece (the apparently normal price from 1481 to 1518) in these years, calculating 24 yds. to the piece, are roughly in proportion to the apparent decreases in quantity, again suggesting that the piece here was longer and that the price and quantity remained unchanged. The price in 1501, however, is higher in proportion to the apparent fall in quantity and probably represents a price-rise as well as a larger piece. From 1520 quantities are irregular and supply no guide to the size of the piece. In 1520 the price given is an average of 2 pieces 8 yds. for £10 10s. and 1 piece 41/2 yds. for £5 7s. 1d., calculating 24 yds. to the piece. In 1522, 1524 and from 1527 onwards prices are quoted per yd. and raised here to the piece of 24 yds., but other prices after 1520 are by the piece and are printed with a warning, as there is no evidence as to its size. For Servants, 1395–1464. Gross 70, Net 49. For Grooms, 1394–1454. Gross 61, Net 34. For Stewards and Gentlemen, 1406–76. Gross 71, Net 46. There has been much controversy as to the nature of this material but it seems probable that English ray was cloth made of russet or dark wool originally undyed,." In Prices and Wages in England, 111. Routledge, 2013. http://dx.doi.org/10.4324/9781315031385-82.

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"Collins, P. 98 structure of 150–1, 152; overt Collinson, D. 58 research on 153–4; and potentials of Community Care 62 confrontation 153–8, 163; reasons Community Relations Councils 171 for studying 158–60; researcher as Cotterill, P. 95, 101, 108; and threat to 154–5; risk of research on Letherby, G. 94, 95, 107 162–3; risk to researcher 153–8; role of researcher in 161–2; Dalley, G. 117 secondary roles for researcher in danger: awareness of 2, 23–4; beyond 155–6; structural/cultural view of researcher/researched 160–2; 151–2; studying 147–8; and trust coping strategies 144; defined 74; in 155–6; validity of research on the field 182; as immediate physical 159–60; and wider community threat 8–9; insights from 189; 160–2; see also groups invisible 80–1; move from empathy Day, G. 107 to sympathy 154–5, 157, 159, 160; Dees, M. and Fiffer, S. 151 multiple aspects 54–5, 133; new delivery suite: attitude to patients agenda 115–18; and political 86–7; description of 81; emotional correctness 169; as positively danger in 82–7; and internal disruptive influence 56; of examination 82–3; and (lack of) representation 168, 179; and knowledge 84–5; and monitoring of research 27–9, 40, 189–92; and births 83–4; and new technology researcher risk 1–7, 9–10, 61; of 81, 85; powerlessness and anger in unreliable knowledge 169; see also 83 risk/danger Denby, S. and Baker, C. 58 dangerous groups 169; acceptance of Denizen, N. 149 researcher in 157; attitude to Dobie, K. 151 presentation of reports on 157–8; door work 43–4, 198–9; assaults, take-basic preparations for studying overs, swimming lessons 48–9; and 163–4; conceptual approach toward the bouncer self 53; and collective 150–2; and confidentiality of trust 51–2; at dance-oriented club material 155–6; covert research on 49–52; and danger 47–53, 54; 153; and data collection 149–50; ethnographic episodes 7–52; at gay defined 148; development of 152; club 48–9; and gender 45, 58; and ethical problems with 156; gaining knowing the score 49–50; links to access to 155; and involvement of criminality 44, 45–6; and losing wider community 160–2; and law ‘bottle’ 48; methodological enforcement 156–7; leadership of concerns 46–7; mythology/reality 156–7; long-term involvement with concerning 44; and personal 156; mechanics of participant information 52; post-fieldwork observation 154; membership/social experience 54–6;." In Danger in the Field, 216. Routledge, 2002. http://dx.doi.org/10.4324/9780203136119-37.

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Conference papers on the topic "1444 or 5-1510"

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Reshetnikova, N. V., and E. Y. Vataeva. "METHODS OF ACS RESEARCH UNDER NON-STATIONARY CONDITIONS." In ZAVALISHENSKY READING’20. St. Petersburg State University of Aerospace Instrumentation, 2020. http://dx.doi.org/10.31799/978-5-8088-1446-2-2020-15-148-151.

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