Log in

Relevant bibliographies by topics / 15-PGDH inhibitor / Journal articles

To see the other types of publications on this topic, follow the link: 15-PGDH inhibitor.

Journal articles on the topic '15-PGDH inhibitor'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 30 journal articles for your research on the topic '15-PGDH inhibitor.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Kishore, Annavarapu Hari, Hanquan Liang, Mohammed Kanchwala, et al. "Prostaglandin dehydrogenase is a target for successful induction of cervical ripening." Proceedings of the National Academy of Sciences 114, no. 31 (2017): E6427—E6436. http://dx.doi.org/10.1073/pnas.1704945114.

Full text

Abstract:

The cervix represents a formidable structural barrier for successful induction of labor. Approximately 10% of pregnancies undergo induction of cervical ripening and labor with prostaglandin (PG) E2 or PGE analogs, often requiring many hours of hospitalization and monitoring. On the other hand, preterm cervical ripening in the second trimester predicts preterm birth. The regulatory mechanisms of this paradoxical function of the cervix are unknown. Here, we show that PGE2 uses cell-specific EP2 receptor-mediated increases in Ca2+ to dephosphorylate and translocate histone deacetylase 4 (HDAC4) t

APA, Harvard, Vancouver, ISO, and other styles

2

Patel, Falguni A., Vicki L. Clifton, K. Chwalisz, and John R. G. Challis. "Steroid Regulation of Prostaglandin Dehydrogenase Activity and Expression in Human Term Placenta and Chorio-Decidua in Relation to Labor1." Journal of Clinical Endocrinology & Metabolism 84, no. 1 (1999): 291–99. http://dx.doi.org/10.1210/jcem.84.1.5399.

Full text

Abstract:

NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) is the key catabolic enzyme controlling levels of biologically active PGs. PGDH is localized to syncytiotrophoblast in placenta, and to trophoblast cells in chorion. To examine the regulation of PGDH by steroids and to determine any changes with labor, we obtained placenta and chorion from term elective cesarean section or spontaneous delivery and isolated trophoblast cells using a Percoll density gradient. Cells were treated with varying concentrations of cortisol, progesterone, the synthetic progestins R5020, and medroxyprogesterone

APA, Harvard, Vancouver, ISO, and other styles

3

Yao, Bing, Jie Xu, Raymond C. Harris, and Ming-Zhi Zhang. "Renal localization and regulation of 15-hydroxyprostaglandin dehydrogenase." American Journal of Physiology-Renal Physiology 294, no. 2 (2008): F433—F439. http://dx.doi.org/10.1152/ajprenal.00436.2007.

Full text

Abstract:

Tissue prostaglandin levels are determined by both biosynthesis and catabolism. The current studies report the expression and localization of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a key enzyme in prostaglandin catabolism in the kidneys. We also investigated potential interactions between 15-PGDH and cyclooxygenase (COX), a key enzyme in prostaglandin biosynthesis. Both 15-PGDH mRNA and protein levels were significantly higher in kidney cortex than in papilla, which is opposite to the expression pattern of COX-2. In situ hybridization indicated that 15-PGDH mRNA was mainly localized

APA, Harvard, Vancouver, ISO, and other styles

4

Liu, Ying, Zhanjun Jia, Ying Sun, et al. "Postnatal regulation of 15-hydroxyprostaglandin dehydrogenase in the rat kidney." American Journal of Physiology-Renal Physiology 307, no. 4 (2014): F388—F395. http://dx.doi.org/10.1152/ajprenal.00512.2013.

Full text

Abstract:

Cyclooxygenase 2 (COX-2) has an established role in postnatal kidney development. 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is recently identified as an endogenous inhibitor of COX-2, limiting the production of COX-2-derived prostanoids in several pathological conditions. The present study was undertaken to examine the regulation of renal 15-PGDH expression during postnatal kidney development in rats compared with COX-2. qRT-PCR and immunoblotting demonstrated that 15-PGDH mRNA and protein in the kidney were present in neonates, peaked in the second postnatal week, and then declined shar

APA, Harvard, Vancouver, ISO, and other styles

5

Hang, L. T. M., and H. Cho. "Synthesis of new thiazolidinedione derivatives as 15-PGDH Inhibitor." Journal of Biotechnology 150 (November 2010): 447. http://dx.doi.org/10.1016/j.jbiotec.2010.09.645.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Wang, Jiping, Nancy L. Cho, Ann G. Zauber, et al. "Expression of COX-2 and 15-PGDH in adenomas removed during pretreatment colonoscopy to predict chemopreventive efficacy of the selective COX-2 inhibitor, celecoxib." Journal of Clinical Oncology 35, no. 4_suppl (2017): 524. http://dx.doi.org/10.1200/jco.2017.35.4_suppl.524.

Full text

Abstract:

524 Background: The APC trial showed that patients at high risk for colorectal adenoma development experienced a 33-45% reduction in post-polypectomy adenoma detection when treated with the selective cyclooxygenase-2 (cox-2) inhibitor, celecoxib. Unfortunately, this study also found a small increased risk of cardiovascular toxicity among celecoxib users, preventing broad use of this agent for chemoprevention. Celecoxib inhibits expression of prostaglandin E2 (PGE2), an inflammatory mediator produced by fatty acid metabolism via cyclooxygenases, and degraded through the activity of 15-prostagla

APA, Harvard, Vancouver, ISO, and other styles

7

Kim, Hye Jung, Sun-Hee Kim, Minjung Kim, et al. "Inhibition of 15-PGDH prevents ischemic renal injury by the PGE2/EP4 signaling pathway mediating vasodilation, increased renal blood flow, and increased adenosine/A2A receptors." American Journal of Physiology-Renal Physiology 319, no. 6 (2020): F1054—F1066. http://dx.doi.org/10.1152/ajprenal.00103.2020.

Full text

Abstract:

In the present study, we demonstrated the marked activity of SW033291, an inhibitor of 15-hydoxyprostaglandin dehydrogenase (15-PGDH), in preventing acute kidney injury (AKI) in a murine model of ischemia-reperfusion injury. AKI due to ischemic injury represents a significant clinical problem. PGE2 is vasodilatory in the kidney, but it is rapidly degraded in vivo due to catabolism by 15-PGDH. We investigated the potential of SW033291, a potent and specific 15-PGDH inhibitor, as prophylactic treatment for ischemic AKI. Prophylactic administration of SW033291 significantly increased renal tissue

APA, Harvard, Vancouver, ISO, and other styles

8

Frenkian, Mélinée, Nadine Segond, Elisabeth Pidoux, Régis Cohen, and Annick Jullienne. "Indomethacin, a COX inhibitor, enhances 15-PGDH and decreases human tumoral C cells proliferation." Prostaglandins & Other Lipid Mediators 65, no. 1 (2001): 11–20. http://dx.doi.org/10.1016/s0090-6980(01)00116-2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

9

Pang, Qianqian, Yuping Xu, Xuan Qi, et al. "The first case of primary hypertrophic osteoarthropathy with soft tissue giant tumors caused by HPGD loss-of-function mutation." Endocrine Connections 8, no. 6 (2019): 736–44. http://dx.doi.org/10.1530/ec-19-0149.

Full text

Abstract:

Background Primary hypertrophic osteoarthropathy (PHO) is a rare genetic multi-organic disease characterized by digital clubbing, periostosis and pachydermia. Two genes, HPGD and SLCO2A1, which encodes 15-hydroxyprostaglandin dehydrogenase (15-PGDH) and prostaglandin transporter (PGT), respectively, have been reported to be related to PHO. Deficiency of aforementioned two genes leads to failure of prostaglandin E2 (PGE2) degradation and thereby elevated levels of PGE2. PGE2 plays an important role in tumorigenesis. Studies revealed a tumor suppressor activity of 15-PGDH in tumors, such as lung

APA, Harvard, Vancouver, ISO, and other styles

10

Wang, Jiping, Nancy L. Cho, Ann G. Zauber, et al. "Chemopreventive Efficacy of the Cyclooxygenase-2 (Cox-2) Inhibitor, Celecoxib, Is Predicted by Adenoma Expression of Cox-2 and 15-PGDH." Cancer Epidemiology Biomarkers & Prevention 27, no. 7 (2018): 728–36. http://dx.doi.org/10.1158/1055-9965.epi-17-0573.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Desai, Amar, Yongyou Zhang, Youngsoo Park, et al. "A second-generation 15-PGDH inhibitor promotes bone marrow transplant recovery independently of age, transplant dose and granulocyte colony-stimulating factor support." Haematologica 103, no. 6 (2018): 1054–64. http://dx.doi.org/10.3324/haematol.2017.178376.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Li, Cunxi, Bhuminder Singh, Ramona Graves-Deal, et al. "Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer." Proceedings of the National Academy of Sciences 114, no. 14 (2017): E2852—E2861. http://dx.doi.org/10.1073/pnas.1618297114.

Full text

Abstract:

We previously reported that single cells from a human colorectal cancer (CRC) cell line (HCA-7) formed either hollow single-layered polarized cysts or solid spiky masses when plated in 3D in type-I collagen. To begin in-depth analyses into whether clonal cysts and spiky masses possessed divergent properties, individual colonies of each morphology were isolated and expanded. The lines thus derived faithfully retained their parental cystic and spiky morphologies and were termed CC (cystic) and SC (spiky), respectively. Although both CC and SC expressed EGF receptor (EGFR), the EGFR-neutralizing

APA, Harvard, Vancouver, ISO, and other styles

13

Tong, Min, and Hsin-Hsiung Tai. "Synergistic Induction of the Nicotinamide Adenine Dinucleotide-Linked 15-Hydroxyprostaglandin Dehydrogenase by an Androgen and Interleukin-6 or Forskolin in Human Prostate Cancer Cells." Endocrinology 145, no. 5 (2004): 2141–47. http://dx.doi.org/10.1210/en.2003-1229.

Full text

Abstract:

Abstract The nicotinamide adenine dinucleotide-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes the oxidation of 15 (S)-hydroxyl group of prostaglandins and lipoxins and participates along with cyclooxygenases and lipoxygenases in controlling the cellular levels of prostaglandins and lipoxins. 15-PGDH could be induced by IL-6 and forskolin in addition to androgens in a time- and dose-dependent manner but not by other cytokines and growth factors in LNCaP cells. Concurrent addition of IL-6 and forskolin showed additive effect in the induction of 15-PGDH activity. However, com

APA, Harvard, Vancouver, ISO, and other styles

14

Miyaki, Akira, Peiying Yang, Hsin-Hsiung Tai, Kotha Subbaramaiah, and Andrew J. Dannenberg. "Bile acids inhibit NAD+-dependent 15-hydroxyprostaglandin dehydrogenase transcription in colonocytes." American Journal of Physiology-Gastrointestinal and Liver Physiology 297, no. 3 (2009): G559—G566. http://dx.doi.org/10.1152/ajpgi.00133.2009.

Full text

Abstract:

Multiple lines of evidence have suggested a role for both bile acids and prostaglandins (PG) in gastrointestinal carcinogenesis. Levels of PGE2 are determined by both synthesis and catabolism. Previously, bile acid-mediated induction of cyclooxygenase-2 (COX-2) was found to stimulate PGE2 synthesis. NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the key enzyme responsible for the catabolism of PGE2, has been linked to colorectal carcinogenesis. In this study, we determined whether bile acids altered the expression of 15-PGDH in human colon cancer cell lines. Treatment with unc

APA, Harvard, Vancouver, ISO, and other styles

15

Wu, Ying, Hsin-Hsiung Tai, and Hoon Cho. "Synthesis and SAR of thiazolidinedione derivatives as 15-PGDH inhibitors." Bioorganic & Medicinal Chemistry 18, no. 4 (2010): 1428–33. http://dx.doi.org/10.1016/j.bmc.2010.01.016.

Full text

APA, Harvard, Vancouver, ISO, and other styles

16

Cho, H., and H. H. Tai. "Inhibition of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by cyclooxygenase inhibitors and chemopreventive agents." Prostaglandins, Leukotrienes and Essential Fatty Acids 67, no. 6 (2002): 461–65. http://dx.doi.org/10.1054/plef.2002.0457.

Full text

APA, Harvard, Vancouver, ISO, and other styles

17

Yang, Sung Yeun, Jin Hee Park, Kyung Han Nam, and SaeGwang Park. "15-PGDH Inhibitors Promote Healing of Gastric Ulcer in Indomethacin Induced Mouse Model." Gastroenterology 152, no. 5 (2017): S560—S561. http://dx.doi.org/10.1016/s0016-5085(17)32029-2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Asati, Vivek, Shalini Bajaj, Debarshi Kar Mahapatra, and Sanjay Kumar Bharti. "Molecular modeling studies of some thiazolidine-2,4-dione derivatives as 15-PGDH inhibitors." Medicinal Chemistry Research 25, no. 1 (2015): 94–108. http://dx.doi.org/10.1007/s00044-015-1442-5.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Tai, C. L., O. T. Mak, T. Arai, and H. H. Tai. "Monoclonal antibodies that inhibit the enzyme activity of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase." Biochemical Journal 267, no. 1 (1990): 75–78. http://dx.doi.org/10.1042/bj2670075.

Full text

Abstract:

Three hybridoma cell lines secreting antibodies against human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-OH-PGDH) were produced. Purified IgG2b from these cell lines recognized a distinct band of Mr 28,000 on SDS/PAGE from the purified enzyme as well as a band of Mr 56,000 from the crude enzyme preparation. These three monoclonal antibodies inhibited 15-OH-PGDH activity to different degrees. Inhibition of the enzyme activity could be prevented by prior incubation of the enzyme with NAD+ but not with prostaglandin E2 (PGE2) or NADP+. Inhibition by monoclonal antibodies

APA, Harvard, Vancouver, ISO, and other styles

20

Gao, Lu, Chunmei Lu, Chen Xu, Yi Tao, Binhai Cong, and Xin Ni. "Differential Regulation of Prostaglandin Production Mediated by Corticotropin-Releasing Hormone Receptor Type 1 and Type 2 in Cultured Human Placental Trophoblasts." Endocrinology 149, no. 6 (2008): 2866–76. http://dx.doi.org/10.1210/en.2007-1377.

Full text

Abstract:

Prostaglandin (PG) production by intrauterine tissues plays a key part in the control of pregnancy and parturition. The present study was to investigate the role of placenta-derived CRH and CRH-related peptides in the regulation of PG synthesis and metabolism. We found that placental trophoblasts expressed both CRH-R1 and CRH-R2. Treatment of cultured placental cells with either a CRH or urocortin I (UCNI) antibody resulted in a significant decrease in PGE2 release. Both CRH and UCNI antibodies significantly decreased mRNA and protein expression of synthetic enzymes cytosolic phospholipase A2

APA, Harvard, Vancouver, ISO, and other styles

21

Ali, Akhtar, Junsik Lim, En Hyung Kim, Jong-Hyun Lee, Shin Seong та Wonnam Kim. "Anti-Inflammatory Effects of Heat-Processed Artemisia capillaris Thunberg by Regulating IκBα/NF-κB Complex and 15-PGDH in Mouse Macrophage Cells". Evidence-Based Complementary and Alternative Medicine 2021 (7 червня 2021): 1–13. http://dx.doi.org/10.1155/2021/5320314.

Full text

Abstract:

Growing evidence suggests that dietary nutrients in herbs and plants are beneficial in improving inflammatory disorders. Artemisia capillaris Thunberg (AC) is a traditional herbal medicine widely used in East Asia to treat pain, hepatotoxicity, and inflammatory disorders. Heat processing is a unique pharmaceutical method used in traditional herbal medicine to enhance the pharmacological effects and safety of medicinal plants. This study demonstrates the anti-inflammatory effects of heat-processed AC (HPAC) in lipopolysaccharide- (LPS-) treated mouse macrophage cells. HPAC reduced LPS-induced i

APA, Harvard, Vancouver, ISO, and other styles

22

Ali, Akhtar, En Hyung Kim, Jong-Hyun Lee, Kang-Hyun Leem, Shin Seong та Wonnam Kim. "Processed Scutellaria baicalensis Georgi Extract Alleviates LPS-Induced Inflammatory and Oxidative Stress through a Crosstalk between NF-κB and KEAP1/NRF2 Signaling in Macrophage Cells". Applied Sciences 11, № 13 (2021): 6055. http://dx.doi.org/10.3390/app11136055.

Full text

Abstract:

Prolonged inflammation results in chronic diseases that can be associated with a range of factors. Medicinal plants and herbs provide synergistic benefits based on the interaction of multiple phytochemicals. The dried root of Scutellaria baicalensis Georgi and its compounds possess anti-inflammatory, anti-oxidative, and anticancer effects. Processing is a traditional method to achieve clinical benefits by improving therapeutic efficacy and lowering toxicity. In this study, we investigated the anti-inflammatory and anti-oxidant effect of processed Scutellaria baicalensis Georgi extract (PSGE) a

APA, Harvard, Vancouver, ISO, and other styles

23

Kangwan, Napapan, Yoon-Jae Kim, Young Min Han, et al. "Sonic hedgehog inhibitors prevent colitis-associated cancer via orchestrated mechanisms of IL-6/gp130 inhibition, 15-PGDH induction, Bcl-2 abrogation, and tumorsphere inhibition." Oncotarget 7, no. 7 (2015): 7667–82. http://dx.doi.org/10.18632/oncotarget.6765.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Sun, Ying, Zhanjun Jia, Gang Liu та ін. "PPARγAgonist Rosiglitazone Suppresses Renal mPGES-1/PGE2 Pathway in db/db Mice". PPAR Research 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/612971.

Full text

Abstract:

Evidence had shown the detrimental effect of prostaglandin (PG) E2 in diabetic nephropathy (DN) of STZ-induced type-1 diabetes but its role in the development of DN of type-2 diabetes remains uncertain. The present study was undertaken to investigate the regulation of PGE2 synthetic pathway and the interaction between peroxisome proliferator-activated receptor (PPAR)γand PGE2 synthesis in the kidneys of db/db mice. Strikingly, urinary PGE2 was remarkably elevated in db/db mice paralleled with the increased protein expressions of COX-2 and mPGES-1. In contrast, the protein expressions of COX-1,

APA, Harvard, Vancouver, ISO, and other styles

25

Prima, Victor, Lyudmila N. Kaliberova, Sergey Kaliberov, David T. Curiel, and Sergei Kusmartsev. "COX2/mPGES1/PGE2pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells." Proceedings of the National Academy of Sciences 114, no. 5 (2017): 1117–22. http://dx.doi.org/10.1073/pnas.1612920114.

Full text

Abstract:

In recent years, it has been established that programmed cell death protein ligand 1 (PD-L1)–mediated inhibition of activated PD-1+T lymphocytes plays a major role in tumor escape from immune system during cancer progression. Lately, the anti–PD-L1 and –PD-1 immune therapies have become an important tool for treatment of advanced human cancers, including bladder cancer. However, the underlying mechanisms of PD-L1 expression in cancer are not fully understood. We found that coculture of murine bone marrow cells with bladder tumor cells promoted strong expression of PD-L1 in bone marrow–derived

APA, Harvard, Vancouver, ISO, and other styles

26

KIm, Byeong Woo, Sun hee Kim, and Ki beom Bae. "P0544INHIBITION OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE (15-PGDH) PROTECTS MICE AGAINST CONTRAST-INDUCED ACUTE KIDNEY INJURY." Nephrology Dialysis Transplantation 35, Supplement_3 (2020). http://dx.doi.org/10.1093/ndt/gfaa142.p0544.

Full text

Abstract:

Abstract Background and Aims Although the mechanism of contrast-induced acute kidney injury (CI-AKI) is not fully known, the imbalance of vasoconstrictive and vasodilative mediators plays a major role. Prostaglandin E2 (PGE2) is one of the vasodilators involved in this process. Inhibition of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) causes elevation of PGE2 level in tissue by delaying the rapid degradation of PGE2 by the enzyme. We tested the hypothesis that the 15-PGE2 inhibitor would protect against CI-AKI in a mouse model and attempted to elucidate the mechanism involved. Method 10-we

APA, Harvard, Vancouver, ISO, and other styles

27

Palla, A. R., M. Ravichandran, Y. X. Wang, et al. "Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength." Science, December 10, 2020, eabc8059. http://dx.doi.org/10.1126/science.abc8059.

Full text

Abstract:

Treatments are lacking for sarcopenia, a debilitating age-related skeletal muscle wasting syndrome. Here we identify elevated 15-PGDH, the Prostaglandin E2 (PGE2)–degrading enzyme, as a hallmark of aged tissues, including skeletal muscle. The resulting reduction in PGE2 signaling is a major contributor to muscle atrophy in aged mice and results from 15-PGDH-expressing myofibers and interstitial cells within muscle. Inhibition of 15-PGDH, by targeted genetic knockdown or a small molecule inhibitor, increases aged muscle mass, strength, and exercise performance. These physiological benefits aris

APA, Harvard, Vancouver, ISO, and other styles

28

KIm, Byeong Woo, Sun hee Kim, and Ki beom Bae. "P0522INHIBITING 15-PGDH PREVENTS ISCHEMIC RENAL INJURY BY A PGE2/EP4 SIGNALING PATHWAY MEDIATING VASODILATION, INCREASED RENAL BLOOD FLOW, AND INCREASED ADENOSINE/A2A RECEPTOR." Nephrology Dialysis Transplantation 35, Supplement_3 (2020). http://dx.doi.org/10.1093/ndt/gfaa142.p0522.

Full text

Abstract:

Abstract Background and Aims We demonstrate the marked activity of SW033291, an inhibitor of 15-hydoxyprostaglandin dehydrogenase (15-PGDH), in preventing acute kidney injury (AKI) in a murine model of ischemia reperfusion injury (IRI). AKI due to ischemic injury represents a significant clinical problem. Prostaglandin E2 (PGE2) is vasodilator in the kidney, but is rapidly degraded in vivo due to catabolism by 15-PGDH. We investigated the potential of SW033291, a potent and specific 15-PGDH inhibitor, as prophylactic treatment for ischemic AKI. Method 10-week aged male C57/BL6 mice were random

APA, Harvard, Vancouver, ISO, and other styles

29

Nettleford, Shaneice, Luming Zhao, James Fraser, et al. "Dietary Selenium in Immune Mechanisms During an Enteric Bacterial Infection (OR12-08-19)." Current Developments in Nutrition 3, Supplement_1 (2019). http://dx.doi.org/10.1093/cdn/nzz049.or12-08-19.

Full text

Abstract:

Abstract Objectives Enteropathogenic Escherichia coli (EPEC) poses a great threat to developing countries, as EPEC can result in diarrhea and colitis in children. Interestingly, the effect of trace element nutritional deficiencies as well as their supplementation on disease pathogenesis is increasingly being recognized. We have previously reported that supplementation of mice with selenium (Se), a trace element that is incorporated into selenoproteins as the 21st amino acid, resulted in the amelioration of chemically induced colitis through the downregulation of pro-inflammatory mediators of t

APA, Harvard, Vancouver, ISO, and other styles

30

Chen, Kun-Ming, Henry Thompson, John P. Vanden-Heuvel, et al. "Lipoxygenase catalyzed metabolites derived from docosahexaenoic acid are promising antitumor agents against breast cancer." Scientific Reports 11, no. 1 (2021). http://dx.doi.org/10.1038/s41598-020-79716-x.

Full text

Abstract:

AbstractDocosahexaenoic acid (DHA) is known to inhibit breast cancer in the rat. Here we investigated whether DHA itself or select metabolites can account for its antitumor action. We focused on metabolites derived from the lipoxygenase (LOX) pathway since we previously showed that they were superior anti-proliferating agents compared to DHA; 4-OXO-DHA was the most potent. A lipidomics approach detected several LOX-metabolites in plasma and the mammary gland in rats fed DHA; we also identified for the first time, 4-OXO-DHA in rat plasma. In a reporter assay, 4-OXO-DHA and 4-HDHA were more effe

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!