Academic literature on the topic '158N murine oligodendrocytes'

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Journal articles on the topic "158N murine oligodendrocytes"

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Zhou, Jie, Marcia R. Terluk, Lisa Basso, et al. "N-acetylcysteine Provides Cytoprotection in Murine Oligodendrocytes through Heme Oxygenase-1 Activity." Biomedicines 8, no. 8 (2020): 240. http://dx.doi.org/10.3390/biomedicines8080240.

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Oligodendrocytic injury by oxidative stress can lead to demyelination, contributing to neurodegeneration. We investigated the mechanisms by which an antioxidant, N-acetylcysteine (NAC), reduces oxidative stress in murine oligodendrocytes. We used normal 158N and mutant 158JP cells with endogenously high reactive oxygen species (ROS) levels. Oxidative stress was induced in 158N cells using hydrogen peroxide (H2O2, 500 μM), and both cells were treated with NAC (50 µM to 500 µM). ROS production, total glutathione (GSH) and cell survival were measured 24 h after treatment. In normal cells, H2O2 tr
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Nury, Thomas, Margaux Doria, Gérard Lizard, and Anne Vejux. "Docosahexaenoic Acid Attenuates Mitochondrial Alterations and Oxidative Stress Leading to Cell Death Induced by Very Long-Chain Fatty Acids in a Mouse Oligodendrocyte Model." International Journal of Molecular Sciences 21, no. 2 (2020): 641. http://dx.doi.org/10.3390/ijms21020641.

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In the case of neurodegenerative pathologies, the therapeutic arsenal available is often directed towards the consequences of the disease. The purpose of this study is, therefore, to evaluate the ability of docosahexaenoic acid (DHA), a molecule present in certain foods and considered to have health benefits, to inhibit the cytotoxic effects of very long-chain fatty acids (C24:0, C26:0), which can contribute to the development of some neurodegenerative diseases. The effect of DHA (50 µM) on very long-chain fatty acid-induced toxicity was studied by several complementary methods: phase contrast
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Kharroubi, Wafa, Thomas Nury, Samia Haj Ahmed, et al. "Induction by arsenate of cell-type-specific cytotoxic effects in nerve and hepatoma cells." Human & Experimental Toxicology 36, no. 12 (2017): 1256–69. http://dx.doi.org/10.1177/0960327116687893.

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The aim of the study was to compare the effect of sodium arsenate (AsV) on two different cell types: 158N murine oligodendrocytes and HepG2 human hepatoma cells. Exposure of 158N cells to AsV (0.1–400 µM; 48 h) induced a biphasic cytoxic effect defined as hormesis. Thus, low concentrations of AsV stimulate cell proliferation, as shown by phase-contrast microscopy, cell counting with trypan blue, and crystal violet assay, whereas high concentrations induce cell death associated with a loss of cell adhesion. These side effects were confirmed by staining with propidium iodide and cell cycle analy
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Ragot, Kévin, John J. Mackrill, Amira Zarrouk, et al. "Absence of correlation between oxysterol accumulation in lipid raft microdomains, calcium increase, and apoptosis induction on 158N murine oligodendrocytes." Biochemical Pharmacology 86, no. 1 (2013): 67–79. http://dx.doi.org/10.1016/j.bcp.2013.02.028.

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Meddeb, Wiem, Leila Rezig, Amira Zarrouk, et al. "Cytoprotective Activities of Milk Thistle Seed Oil Used in Traditional Tunisian Medicine on 7-Ketocholesterol and 24S-Hydroxycholesterol-Induced Toxicity on 158N Murine Oligodendrocytes." Antioxidants 7, no. 7 (2018): 95. http://dx.doi.org/10.3390/antiox7070095.

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The Asteraceae family is economically very important, because many of these plants are grown mainly for their food value, such as lettuce (Lactuca), chicory (Cichorium), and sunflower (Heliantus aminus). One of the typical properties of this family, which includes milk thistle (Sylibum marianum), is the richness of the oil in various compounds (flavonoids, alkaloids, tocopherols, and unsaturated fatty acids). Currently, and for the coming decades, age-related diseases, including neurodegenerative diseases, are a major public health problem. Preventing their appearance or opposing their evoluti
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Badreddine, Asmaa, Amira Zarrouk, El Mostafa Karym, et al. "Argan Oil-Mediated Attenuation of Organelle Dysfunction, Oxidative Stress and Cell Death Induced by 7-Ketocholesterol in Murine Oligodendrocytes 158N." International Journal of Molecular Sciences 18, no. 10 (2017): 2220. http://dx.doi.org/10.3390/ijms18102220.

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Sghaier, Randa, Amira Zarrouk, Thomas Nury та ін. "Biotin attenuation of oxidative stress, mitochondrial dysfunction, lipid metabolism alteration and 7β-hydroxycholesterol-induced cell death in 158N murine oligodendrocytes". Free Radical Research 53, № 5 (2019): 535–61. http://dx.doi.org/10.1080/10715762.2019.1612891.

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Sghaier, Randa, Thomas Nury, Valerio Leoni та ін. "Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrial alterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol". Journal of Steroid Biochemistry and Molecular Biology 194 (листопад 2019): 105432. http://dx.doi.org/10.1016/j.jsbmb.2019.105432.

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Ragot, Kévin, Dominique Delmas, Anne Athias, Thomas Nury, Mauhamad Baarine та Gérard Lizard. "α-Tocopherol impairs 7-ketocholesterol-induced caspase-3-dependent apoptosis involving GSK-3 activation and Mcl-1 degradation on 158N murine oligodendrocytes". Chemistry and Physics of Lipids 164, № 6 (2011): 469–78. http://dx.doi.org/10.1016/j.chemphyslip.2011.04.014.

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Bezine, Maryem, Meryam Debbabi, Thomas Nury, et al. "Evidence of K + homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes." Chemistry and Physics of Lipids 207 (October 2017): 135–50. http://dx.doi.org/10.1016/j.chemphyslip.2017.03.006.

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Dissertations / Theses on the topic "158N murine oligodendrocytes"

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Meddeb, Wiem. "Extraction, caractérisation physicochimique, profil lipidique et activité cytoprotectrice d'huiles de Chardon-Marie de Tunisie." Thesis, Bourgogne Franche-Comté, 2018. http://www.theses.fr/2018UBFCK063.

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La famille des Astéracées est économiquement très importante, car beaucoup de ses plantessont cultivées principalement pour leurs valeurs alimentaires dont la laitue (Lactuca), lachicorée (Cichorium) et le tournesol (Heliantus annuus) cultivé pour son huile. Une despropriétés typiques de cette famille, dont fait partie le Silybum marianum, est la richesse deses huiles en divers composés naturels bénéfiques pour la santé. Actuellement et pour lesdécennies à venir, les maladies liées à l’âge constituent un problème majeur de santépublique. Prévenir leur apparition ou s'opposer à leur évolution e
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Bezine, Maryem. "Implication du canal potassium Kv3.1 dans la lipotoxicité du 7-cétocholestérol, 24S-hydroxycholestérol et de l’acide tétracosanoïque sur des cellules nerveuses 158N et BV-2 : Etude des relations entre Kv3.1, homéostasie potassique et métabolisme peroxysomal dans la maladie d’Alzheimer." Thesis, Bourgogne Franche-Comté, 2017. http://www.theses.fr/2017UBFCI010/document.

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Le potassium (K+) est impliqué dans la régulation de l’excitabilité cellulaire, la régulation du cycle cellulaire, la viabilité cellulaire, la neuroprotection et le maintien des fonctions microgliales et oligodendrocytaires. Le dysfonctionnement des canaux potassiques, décrit dans plusieurs maladies neurodégénératives comme la Maladie d’Alzheimer (MA), la sclérose en plaques (SEP), la maladie de Parkinson et la maladie de Huntington, pourrait être une potentiel cible thérapeutique. Les mécanismes toxiques sous-jacents de ces pathologies neurodégénératives impliquent des oxystérols, dérivés oxy
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