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Journal articles on the topic '159. 922-27 (043.20)'

Author: Grafiati

Published: 30 May 2022

Last updated: 31 July 2025

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1

Upadhyah Amit A. "Analysis of One Best MCQS in Five Preuniversity Physiology Examinations." International Journal of Physiology 7, no. 4 (2019): 10–15. http://dx.doi.org/10.37506/ijop.v7i4.47.

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Objectives One-best MCQs (Multiple Choice Questions) is a popular form of assessment where the student selects the best possible answer from the options provided. The objective of this study was to analyze the MCQs used in preliminary examinations in terms of Difficulty Index, Differentiation Index and Distracter efficiency. Method Total 100 MCQ items with one correct option and three distracters were taken from past 5 years preuniversity examinations and analyzed for level of difficulty and power of discrimination. A total of 149, 156, 154, 156 and 148 students appeared for

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Onarici Gungor, Elvin. "Oxygen Uptake Off-Transient Kinetics Responses to Exercises." Journal of Educational Issues 8, no. 1 (2022): 680. http://dx.doi.org/10.5296/jei.v8i1.19916.

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The kinetics of oxygen uptake during recovery is defined off-transient kinetics (Sousa et al., 2015). The purpose of this study was to compare the VO2 off-transient kinetics response of physical education students and also compare the different exercise intensities. Physical education students were grouped as males (n = 10) and females (n = 10). Subjects performed an incremental exercise test for the determination of cardiorespiratory responses. Subjects also performed below threshold exercise on different day. Oxygen uptake was tested via CPX Oxygen analyzer. Off-transient kinetics were model

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Rodriguez, Karla Baez, Nicole Torres Rivera, Janevi Rebernigg, et al. "PSUN146 Diabetes, Obesity, and Diabetes-Obesity Overlap Syndrome in Hospitalized Adult COVID-19 Patients: Comorbidity Dose is The Thing!" Journal of the Endocrine Society 6, Supplement_1 (2022): A365. http://dx.doi.org/10.1210/jendso/bvac150.758.

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Abstract Excess risk for mortality in hospitalized adults with COVID-19 has been linked to extant chronic conditions, especially obesity (Obes), diabetes (DM) or combination (ObesDM). We investigated dose-response interactions between Elixhauser Comorbidity Index (ECI) and comorbidity ensembles including Obes, DM, ObesDM or Control. Presentation demographics, putative COVID-19 severity markers, and administrative data including ICD-10 codes to measure ECI (AHRQ, v2022.1, 0-38 categories) were extracted under IRB exemption from electronic medical records. Youden's J statistic identified ECI35 p

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Harrowfield, Jack M., Raj Pal Sharma, Brian W. Skelton, and Allan H. White. "Structural Systematics of 2/4-Nitrophenoxide Complexes of Closed-Shell Metal Ions. III 2/4-Nitrophenoxides of Univalent Heavy Metals." Australian Journal of Chemistry 51, no. 8 (1998): 735. http://dx.doi.org/10.1071/c97100.

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Room-temperature single-crystal X-ray studies are recorded for 2- and 4-nitrophenoxide salts of silver(I) and thallium(I), M(2-np) and Tl(4-np) (anhydrous), and Ag(4-np).H2O. Ag(2-np) is monoclinic, P21/c, a 9·012(4), b 5·743(5), c 12·594(5) Å, β 104·34(4)°, Z = 4; conventional R on |F| was 0·042 for No 1378 independent ‘observed’ (I > 3σ(I)) reflections. Tl(2-np) is monoclinic, C2/c, a 27·250(3), b 3·712(1), c 15·147(3) Å, β 114·41(1)°, Z = 8, R 0·025 for No 1346. Ag(4-np).H2O is monoclinic, P21/a, a 5·613(6), b 13·191(7), c 9·844(5) Å, β 92·50(6)°, Z = 4, R 0 ·033 for No 622. Tl(4-np) is

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Aslam, Faizan, Helee Patel, and Pablo Garcia-Reitboeck. "003 Diagnostic workup in suspected viral encephalitis-a single centre audit." Journal of Neurology, Neurosurgery & Psychiatry 90, no. 12 (2019): e12.3-e12. http://dx.doi.org/10.1136/jnnp-2019-abn-2.37.

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The British Infection Society and Association of British Neurologists published joint guidelines in 2012 for the management of encephalitis. We wanted to audit our practice. We analysed data from discharge summaries of 150 patients admitted to St George’s Hospital who underwent a lumbar puncture (LP) between March-December 2017. We identified 30 patients with suspected encephalitis. Time to LP was 30.47 ± 6.98 hours. Opening pressure was documented in 14/30(46.6%) whereas paired serum glucose was sent in 6/30(20%) cases. Neuroimaging was performed prior to lumbar puncture with a mean time of 7

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Al-Louzi, Omar, Vijay Letchuman, Sargis Manukyan, et al. "Central Vein Sign Profile of Newly Developing Lesions in Multiple Sclerosis." Neurology - Neuroimmunology Neuroinflammation 9, no. 2 (2022): e1120. http://dx.doi.org/10.1212/nxi.0000000000001120.

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Background and ObjectivesThe central vein sign (CVS), a central linear hypointensity within lesions on T2*-weighted imaging, has been established as a sensitive and specific biomarker for the diagnosis of multiple sclerosis (MS). However, the CVS has not yet been comprehensively studied in newly developing MS lesions. We aimed to identify the CVS profiles of new white matter lesions in patients with MS followed over time and investigate demographic and clinical risk factors associated with new CVS+ or CVS− lesion development.MethodsIn this retrospective longitudinal cohort study, adults from t

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Sakuma, Shiho, Eiko Otake, Kan Torii, et al. "Photodynamic therapy with glycoconjugated chlorin photosensitizer." Journal of Porphyrins and Phthalocyanines 17, no. 05 (2013): 331–42. http://dx.doi.org/10.1142/s1088424613500065.

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Photodynamic therapy (PDT) effectively induces tumor cell apoptosis, but the tumor selectivity and photosensitivity of common photosensitizers, such as aspartyl chlorin (NPe6), are not sufficient. Cancer cells phagocytose glucose 3 to 20 times more efficiently than normal cells; therefore, we examined whether glycoconjugation improves photosensitizer tumor-localizability. HaCaT cells were incubated with H2TFPC (unconjugated chlorin), H2TFPC-SGlc (glycoconjugated chlorin), or NPe6, followed by irradiation with 633 nm LED light (16 J.cm-2). PDT with 1 μM H2TFPC-SGlc for 24 h induced significantl

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Jamaludin, Jamaludin, Muhammad Buttomi Masgode, Arman Hidayat, and Mutiara Indah. "Uji Kekuatan Tekan Beton FC’ 20 MPa Dengan Menggunakan Semen OPC dan Bahan Aditif SP Sikament-ln." Mining Science And Technology Journal 3, no. 1 (2024): 51–56. http://dx.doi.org/10.54297/minetech-journal.v3i1.596.

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Pembangunan infrastruktur di Indonesia tidak lepas dari penggunaan beton. Pondasi, plat lantai, kolom, bendungan, jalan, dan jembatan adalah semua pekerjaan yang menggunakan beton. Tujuan dari penelitian ini adalah untuk menentukan kekuatan tekan beton dengan mutu rencana Fc 20 Mpa yang menggunakan semen OPC dan aditif Sikament-LN. Pengujian ini menggunakan metode eksperimen di laboratorium PT. PP sesuai dengan standar nasional Indonesia (SNI). 30 sampel, dengan ukuran 150 mm x 300 mm, (27 sampel aditif dan 9 sampel non-aditif), memiliki umur rencana 7, 14 dan 28 hari. Hasil pengujian kuat tek

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Kim, Nam Hee. "Factors Affecting Pro-Environmental Behavior of Nursing Students." Crisis and Emergency Management: Theory and Praxis 18, no. 8 (2022): 135–44. http://dx.doi.org/10.14251/crisisonomy.2022.18.8.135.

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The purpose of this study is to identify factors that influence pro-environmental behaviors of nursing students. Data were collected from May 11 to May 25, 2022 from 152 nursing college students. Collected data analysis were performed using SPSS Win 25.0 program. There was a significant difference in environmental perception(F=3.209, p=.043), environmental sensitivity(F=10.218, p<.001), and pro-environmental behaviors (F=6.668, p=.002) according to grades. There was a significant difference in sensitivity according to gender(t=2.378, p=.019). Perception showed a significant positive correla

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Agarkov, N. M., O. I. Okhotnikov, S. I. Korneeva, et al. "Pleiotropic effect of chronotherapy with a fixed combination of amlodipine, lisinopril and rosuvastatin on the psychological state in elderly hypertensive patients with metabolic syndrome." "Arterial’naya Gipertenziya" ("Arterial Hypertension") 27, no. 5 (2021): 536–45. http://dx.doi.org/10.18705/1607-419x-2021-27-5-536-545.

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Background. Hypertension (HTN) in metabolic syndrome (MS) in the elderly contributes to the formation of cognitive disorders and anxiety-depressive disorders. Objective. To study the psychological state of elderly patients with HTN and MS treated by evening versus morning dosing of a fixed combination (FC) of amlodipine, lisinopril and rosuvastatin. Design and methods. In a randomized, double-blind, controlled trial 63 patients aged 60–74 years with HTN and MS received a FC of amlodipine, liiznopril and rosuvastatin at a dose of 5/10/10 mg in the evening (after 20:00 hours) (study group) And 5

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Nolan, Annette L., Christine C. Allen, Robert C. Burns, Donald C. Craig, and Geoffrey A. Lawrance. "Monomeric and Dimeric Cobalt(III) Polyoxomolybdates: Crystal Structures and Cyclic Voltammetry of Na3 [H6CoMo6O24].8H2O and K6 [H4Co2Mo10O38].7H2O." Australian Journal of Chemistry 51, no. 9 (1998): 825. http://dx.doi.org/10.1071/c97218.

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The crystal structures of Na3 [H6CoMo6O24].8H2O and K6 [H4Co2Mo10O38].7H2O have been determined by X-ray diffraction. The monomer, Na3 [H6CoMo6O24].8H2O, is triclinic, space group P-1, a 6·451(1), b 10·866(2), c 10·922(2) Å, α 109·20(1), β 106·90(1), γ 95·43(1)°, V 676·3(2) Å3, Z 1, and the structure was solved to an R1 value of 0·0243 (wR2 0·0784) for 3761 independent observed reflections. The anion exhibits the well known Anderson structure with six octahedral MoO6 edge-sharing units surrounding the central ‘CoO6’ octahedron, with all metals in a common plane. The dimer, K6 [H4Co2Mo10O38].7H

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Barikiyah, Saeril, and Ipung Fitri Purwanti. "EVALUASI SISTEM JARINGAN DISTRIBUSI AIR MINUM PERUSAHAAN UMUM DAERAH AIR MINUM X ZONA PELAYANAN Y." Jurnal Purifikasi 23, no. 2 (2025): 67–79. https://doi.org/10.12962/purifikasi.v23i2.462.

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Tingkat kehilangan air Perusahaan Umum Daerah Air Minum X sebesar 26,47% dan zona pelayanan Y volume kehilangan air sebesar 19,2 %, volume kehilangan air didominasi oleh kehilangan air secara fisik sebesar 25,4 % dan kehilangan air non fisik sebesar 8,1 %. Berdasarkan Peraturan Menteri Pekerjaan Umum dan Perumahan Rakyat Republik Indonesia No 27/PRT/M/2016 bahwa batas maksimum tingkat kehilangan air sebesar 20%. Tujuan penelitian ini yaitu untuk mengevaluasi jaringan distribusi perpipaan pada Perusahaan Umum Daerah Air Minum X zona pelayanan Y. Metode penelitian ini yaitu analisis jaringan dis

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Zblewski, Darci, Ramy A. Abdelrahman, Dong Chen, Joseph H. Butterfield, Ayalew Tefferi, and Animesh Pardanani. "Patient Reported Symptoms and Tryptase Levels in WHO-Defined Systemic Mastocytosis (SM) Versus Mast Cell Activation Syndrome (MCAS) Versus Neither." Blood 124, no. 21 (2014): 3204. http://dx.doi.org/10.1182/blood.v124.21.3204.3204.

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Abstract Introduction: The utility of patient reported symptoms and serum tryptase levels in distinguishing those with systemic mastocytosis (SM) versus mast cell activation syndrome (MCAS) versus those not meeting formal diagnostic criteria for SM or MCAS has not been systematically examined. Methods: This study was approved by our institutional review board. Patients were referred for suspected SM based on symptoms of mast cell activation, osteopenia, skin rash, etc., or had an established diagnosis of SM. All patients were given a Mastocytosis Symptom Assessment Form (MastSAF) to complete a

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Arora, Mukta, Steven Pavletic, Claudio Anasetti, et al. "Graft-Versus-Leukemia Effect Is Equivalent in Recipients of Matched Sibling and Matched Unrelated Donor Conventional Hematopoietic Cell Transplant." Blood 110, no. 11 (2007): 3049. http://dx.doi.org/10.1182/blood.v110.11.3049.3049.

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Abstract Anti-leukemia effects of allotransplants are largely mediated by immune mechanisms collectively termed graft-versus-leukemia (GvL). We postulated that allotransplants from HLA-matched unrelated donors (URD) have greater GvL activity than similar transplants from HLA-identical siblings because of greater genetic-disparity between donor and recipient. We tested this hypothesis in 4099 adult recipients of HLA-matched sibling (N= 3158) or 8/8 HLA-allele-matched URD (N= 941) transplants for acute leukemia (AML and ALL) and chronic myeloid leukemia (CML) receiving conventional transplants b

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15

Neyton, J., and C. Miller. "Potassium blocks barium permeation through a calcium-activated potassium channel." Journal of General Physiology 92, no. 5 (1988): 549–67. http://dx.doi.org/10.1085/jgp.92.5.549.

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Single high-conductance Ca2+-activated K+ channels from rat skeletal muscle were inserted into planar lipid bilayers, and discrete blocking by the Ba2+ ion was studied. Specifically, the ability of external K+ to reduce the Ba2+ dissociation rate was investigated. In the presence of 150 mM internal K+, 1-5 microM internal Ba2+, and 150 mM external Na+, Ba2+ dissociation is rapid (5 s-1) in external solutions that are kept rigorously K+ free. The addition of external K+ in the low millimolar range reduces the Ba2+ off-rate 20-fold. Other permeant ions, such as Tl+, Rb+, and NH4+ show a similar

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Iqbal, Sarosh, Shumaila Kiran, Shahida Perveen, et al. "Synthesis and Evaluation of Bis-Schiff Bases of Carbohydrazide as Antioxidant and Cytotoxic Agents." Medicinal Chemistry 18, no. 6 (2022): 667–78. http://dx.doi.org/10.2174/1573406418666211220123403.

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Introduction: Antioxidants are known to prevent oxidative stress-induced damage to the biomolecules and thus, delay the onset of cancers and many age-related diseases. Therefore, the development of novel and potent antioxidants is justified. Method: During this study, we synthesized symmetrical Bis-Schiff bases of carbohydrazide 1-27, and evaluated their in vitro antioxidative activity and cytotoxic activity. Results: Among synthesized compounds, six compounds 20 (IC50 = 12.89 ± 0.02 μM), 16 (IC50 = 14.32 ± 0.43 μM), 17 (IC50 = 18.52 ± 0.83 μM), 19 (IC50 = 22.84 ± 0.62 μM), 24 (IC50 = 35.1 ± 0

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Martynova, A., T. Popkova, A. Aleksankin, and E. Gerasimova. "AB0068 B- AND T- LYMPHOCYTE SUBSETS IN PATIENTS WITH EARLY AND PROGRESSED RHEUMATOID ARTHRITIS." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 1064.2–1065. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3816.

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Background:Role of B- and T- lymphocytes is well established in pathogenesis of rheumatoid arthritis (RA). Self-containing activation of B-cells in ectopic germinative centers is followed by auto-activation of T-lymphocytes while T-cells themselves are antigen-presenting cells for B-lymphocytes [1-2]. As these processes continue with the duration of RA, different subsets of B- and T-cell might be prevalent at different stages of RA.Objectives:Evaluate differences in dynamics of B- and T- cell subsets in early and progressed RA.Methods:53 patients with diagnosed RA(ACR/EULAR 2010 criteria) were

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Ball, Lynne M., Maria-Ester Bernardo, Helene Roelofs, et al. "Co-Transplantation of HLA-Haploidentical, Bone Marrow Derived Mesenchymal Stem Cells Prevents Graft Failure and Improves Hematological Recovery in T-Cell Depleted Haploidentical Stem Cell Transplantation." Blood 110, no. 11 (2007): 3073. http://dx.doi.org/10.1182/blood.v110.11.3073.3073.

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Abstract Haploidentical CD34+ purified peripheral blood stem cell transplantation (PBSCT) is associated with an increased risk of graft failure/rejection. Animal models suggest that MSCs may promote engraftment after hematopoietic stem cell transplanation (HSCT) but there role in overcoming graft failure in human HSCT is still unclear. We recently reported our initial findings in 13 children receiving MSCs in conjunction with haplo-PBSCT. Here we report our extended series of 20 patients, now including those with MDS known to have an increased risk of rejection. MSCs were isolated from marrow

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Щедрин, Вячеслав Николаевич, Александр Николаевич Бабичев, Дмитрий Петрович Сидаренко, Валерий Алексеевич Монастырский, Владимир Игоревич Ольгаренко та Александр Алексанрович Рубцов. "Воздействие прецизионного орошения на накопление влаги предшественником озимой пшеницы в условиях недостатка атмосферных осадков". Аграрная Россия, № 12 (22 грудня 2024): 27–31. https://doi.org/10.30906/1999-5636-2024-12-27-31.

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Оценена эффективность прецизионного орошения на мелиорируемых землях в условиях дефицита доступных водных ресурсов, направленных на ресурсосбережение и повышение плодородия почв аридной зоны юга России. Полевые исследования в 2019 – 2020 гг. проводили в Ростовской области на орошаемых землях. Климат района характеризуется как засушливый и вместе с тем недостаточно жаркий. Распределение осадков в период вегетации озимой пшеницы происходит крайне неравномерно. Все эти особенности климата создают значительные трудности при возделывании озимой пшеницы. Почвы опытного участка по всему профилю предс

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Penz, Daniela, Elisabeth Waldmann, Monika Hackl, et al. "Colorectal Cancer and Precursor Lesion Prevalence in Adults Younger Than 50 Years Without Symptoms." JAMA Network Open 6, no. 12 (2023): e2334757. http://dx.doi.org/10.1001/jamanetworkopen.2023.34757.

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ImportanceIncidence of colorectal cancer (CRC) is increasing among younger adults. However, data on precursor lesions in patients who are asymptomatic, especially those aged younger than 50 years, are lacking.ObjectiveTo analyze the prevalence and number needed to screen (NNS) for adenomas, advanced adenomas, and serrated lesions, as well as the incidence of CRC in patients older than age 20 years.Design, Setting, and ParticipantsThis cohort study was conducted among 296 170 patients who received a screening colonoscopy within a national screening colonoscopy registry from 2012 to 2018 in Aust

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Osafo, E. L. K., E. Owen, A. N. Said, M. Gill, and J. Sherington. "Effects of amount offered and chopping on intake and selection of sorghum stover by Ethiopian sheep and cattle." Animal Science 65, no. 1 (1997): 55–62. http://dx.doi.org/10.1017/s1357729800016295.

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AbstractExperiment 1, with rams (17·0 kg initial weight (M)), and experiment 2, with steers (203 kg M), involved 2 × 2 arrangements of treatments to compare the effect of doubling the amount of stover offered (25 or 50 g/kg M daily) and chopping (unchopped or chopped), upon intake, selection and live-weight change. The stover used was a non-bird-resistant, local variety (Dinkamash). The particle length distribution of the chopped stover (produced by a tractor-driven chaff cutter) was: <4·5 mm, 0·148; 4·5 to 8 mm, 0·157; 8 to 12 mm, 0·181; 12 to 20 mm, 0·269; 20 to 33 mm, 0·168; 33 to 54 mm,

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Dombret, Hervé, Alexandra Coelho, Laurène Fenwarth, et al. "Treatments and Outcomes of Adult Patients with AML in the Real-Life - First Report of the French Observational ALFA-PPP Study." Blood 144, Supplement 1 (2024): 2424. https://doi.org/10.1182/blood-2024-207226.

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Introduction. AML treatment options have been recently enriched. New agents like gemtuzumab ozogamicin (GO), FLT3 or IDH inhibitors, or CPX-351 have been approved for some patient subsets. Less-intensive options, like the AZA-VEN combination, are used in older/unfit patients. However, while treatments and indications are standardized, their choice is not, depending on often-subjective factors. This makes observational studies so important to describe the real-life management and outcomes of AML patients. Methods. In 2022, the ALFA group initiated a 2-cohort (newly diagnosed, relapsed/refractor

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Liao, Wei, Matthew Paul Smeltzer, Jordan Goss, et al. "Lung cancer diagnosis rates (LCDR) in lung cancer screening (LCS) and incidental pulmonary nodule (IPN) cohorts in the Mississippi Delta." Journal of Clinical Oncology 43, no. 16_suppl (2025): 8002. https://doi.org/10.1200/jco.2025.43.16_suppl.8002.

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8002 Background: The LCDR in the CT screened cohort in the National Lung Screening Trial (NLST) was 1.1% over a median of 6.5 years follow up. We evaluated the LCDR in a regional US community. Methods: Prospective cohort study of patients in LCS and IPN programs in 22 facilities across a 125 county service area population. We compared LCDR over 3 years in LCS stratified by Lung-RADS (L-R) score (1 to 4X), IPN by nodule size (≤6, >6-15, >15-20, >20-30 mm) on initial CT scans. Comparisons used Chi-square tests, Wilcoxon tests, and Cox regression models with Hazard Ratios (HR) for lung c

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Ambler, Kimberley LS, Linda M. Vickars, Chantal S. Leger, et al. "Clinical Features, Treatment, and Outcome of Severe HIV-Associated Immune Thrombocytopenic Purpura In the HAART Era." Blood 116, no. 21 (2010): 2522. http://dx.doi.org/10.1182/blood.v116.21.2522.2522.

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Abstract Abstract 2522 Background: The association between HIV and immune thrombocytopenic purpura (ITP) is well documented. Although HIV-associated ITP responds both to highly active anti-retroviral therapy (HAART) and treatments used in classic ITP, the clinical features of HIV-associated ITP were documented prior to the widespread use of HAART, and there are currently no widely accepted guidelines for the management of HIV-associated ITP. Here we describe the clinical features, treatment, and outcomes of patients diagnosed with severe HIV-associated ITP in the HAART era. Methods: We searche

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K. Kh., Almagambetov, Sarmurzina Z. S., Chshelkina A. A., et al. "VIABILITY AND ANTAGONISM OF CRYOPRESERVED LACTIC ACID BACTERIA." HERALD OF SCIENCE OF S SEIFULLIN KAZAKH AGRO TECHNICAL RESEARCH UNIVERSITY : Veterinary sciences, no. 3(003) (September 28, 2023): 42–49. http://dx.doi.org/10.51452/kazatuvc.2023.3(003).1500.

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Preserving and advancing bioresources involving industrial microorganisms is of paramount importance for every nation. However, long-term storage of these strains often leads to diminished viability and biological activity. Thus, it is crucial to investigate the properties of cryopreserved strains stored at -80°C in a 10% glycerol solution within low-temperature refrigerators. This study aimed to comparatively analyze the viability of 129 lactic acid bacteria strains, including Lactobacillus sp., Lactococcus sp., and Pediococcus sp., cryopreserved from 2006 to 2020. Among them, 93 Lactobacillu

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Bowmaker, Graham A., Effendy, Robert D. Hart, John D. Kildea, and Allan H. White. "Lewis-Base Adducts of Group 11 Metal(I) Compounds. LXXIII Synthesis, Spectroscopy and Structural Systematics of New 1 : 1 'Cubane' Tetramers of Copper(I) and Silver(I) Halides with Triphenylarsine." Australian Journal of Chemistry 50, no. 6 (1997): 653. http://dx.doi.org/10.1071/c96039.

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Syntheses and room-temperature single-crystal X-ray structural characterization of a number of 1 : 1 ‘cube tetramer’ adducts of copper(I) and silver(I) halides, MX, with triphenylarsine, AsPh3, are recorded, being [XM(AsPh3)]4. The CuBr adduct, obtained unsolvated from toluene, orthorhombic Pbcn, a 17·844(5), b 20·778(8), c 18·430(4) Å, Z = 4 tetramers, conventional R on |F| 0·058 for No 1309 independent ‘observed’ reflctions (I > 3σ(I)), is isomorphous with previously recorded [ClAg(PPh3)]4, the tetramer having crystallographically imposed 2 symmetry. The CuI adduct, previously recorded as

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Huber, Sandra, Stephan Hutter, Constance Regina Baer, et al. "Similarities and Differences of DNMT3A, TET2 and ASXL1 Mutations across Ccus, MDS and AML." Blood 144, Supplement 1 (2024): 1819. https://doi.org/10.1182/blood-2024-200561.

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Background: The most frequently mutated genes in clonal hematopoiesis (CH) occurring during aging are DNMT3A, TET2, and ASXL1 (DTA). DTA mutations (mut) also recurrently occur in overt myeloid malignancies. Aim: Analyze similarities and differences regarding incidence, co-aberrations and clonal hierarchy across CCUS, MDS and AML in patients with DTAmut. Methods: We analyzed 1,604 samples (received 2005-2021) of patients (median age: 71 years [2-93]; female: 42%) diagnosed with CCUS (n=222) or a non-therapy related myeloid malignancy (MDS: n=637; AML: n=745). All samples were analyzed by WGS (m

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Nielsen, Niels Erik, Julia Baranowska, Peter Bramlage, and Jacek Baranowski. "Minimizing the risk for left ventricular rupture during transcatheter aortic valve implantation by reducing the presence of stiff guidewires in the ventricle." Interactive CardioVascular and Thoracic Surgery 29, no. 3 (2019): 365–70. http://dx.doi.org/10.1093/icvts/ivz107.

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Abstract OBJECTIVES The presence of a stiff guidewire in the apex of the left ventricle (LV) is a known risk factor for LV perforation. Our goal was to minimize the risk of LV rupture during transcatheter aortic valve implantation (TAVI) by omitting the interaction between the stiff guidewire and the LV apex using a modified procedure. METHODS A TAVI protocol designed to allow minimal interaction between a stiff guidewire and the LV was developed in Linköping University Hospital in Sweden. A total of 316 patients were treated exclusively by this approach between March 2014 and May 2018. RESULT

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Barclay, J. K., and M. Hansel. "Free radicals may contribute to oxidative skeletal muscle fatigue." Canadian Journal of Physiology and Pharmacology 69, no. 2 (1991): 279–84. http://dx.doi.org/10.1139/y91-043.

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We used mouse soleus in vitro (n = 30) and canine gastrocnemius–plantaris preparations (n = 20) pump-perfused at the animal's blood pressure to establish if free radicals contribute to fatigue in oxidative skeletal muscle. The soleus from each leg contracted for 200 ms (70 Hz) once every minute for 60 min in Hepes buffer gassed with 100% oxygen at 27 °C. When contracting in Hepes alone, both muscles fatigued at 0.9 mN/mm2∙min over the 60 min. The addition of purines to the bath increased the rate to 1.4 mN/mm2∙min and the addition of xanthine oxidase to generate free radicals increased the rat

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Broz, Pavel, Daniel Rajdl, Jaroslav Racek, Jana Zenkova, and Vlasta Petrikova. "Influence of pneumatic tube system transport on routinely assessed and spectrophotometric cerebrospinal fluid parameters." Clinical Chemistry and Laboratory Medicine (CCLM) 55, no. 1 (2017): 47–52. http://dx.doi.org/10.1515/cclm-2016-0143.

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Abstract Background: Pneumatic tube systems (PTS) are widely used in many hospitals. Using PTS reduces turnaround time (TAT) and can improve patients’ outcome. Methods: We investigated whether clinically significant differences could be observed in CSF samples transported by pneumatic tube in comparison with samples transported by hand. Two aliquots from one sample were sent by PTS and by hand from the department of neurology or neurosurgery and compared. Results: Routine cytological and biochemical assessment was compared in 27 cases. There were no statistically significant changes (transport

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Lu, Dao-Pei, Lujia Dong, Tong Wu, et al. "Conditioning including antithymocyte globulin followed by unmanipulated HLA-mismatched/haploidentical blood and marrow transplantation can achieve comparable outcomes with HLA-identical sibling transplantation." Blood 107, no. 8 (2006): 3065–73. http://dx.doi.org/10.1182/blood-2005-05-2146.

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AbstractThe outcomes of 293 patients with leukemia undergoing HLA-identical sibling (n = 158) or related HLA-mismatched (n = 135) hematopoietic cell transplantation (HCT) performed during the same time period were compared. Patients received BUCY2 in HLA-identical sibling HCT or BUCY2 + ATG in mismatched HCT as conditioning regimens, followed by unmanipulated marrow and/or peripheral blood (PB) transplantation. All patients achieved full engraftment. The cumulative incidences of grades II to IV acute graft-versus-host disease (aGVHD) in the matched and mismatched cohorts were 32% (CI, 25%-39%)

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Hilgendorf, Inken, Brigitte Mueller-Hilke, Guenther Kundt, et al. "Lymphocyte Subsets In Chronic Gvhd – a Key Role for B Cells?" Blood 116, no. 21 (2010): 2311. http://dx.doi.org/10.1182/blood.v116.21.2311.2311.

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Abstract Abstract 2311 Background: Chronic graft-versus host disease (cGVHD) features certain similarities with autoimmune diseases. The pathogenesis of cGVHD after allogeneic hematopoietic stem cell transplantation (alloHSCT), however, is poorly understood. Methods: Peripheral blood samples from 52 pts with active (median day 976, range 177–2773) (group 1), 28 pts with resolved (median day 1207, range 147–2849) (group 2) and 18 pts without cGVHD (median day 1015, range 124–2655) (group 3) were analysed for T and B cell subsets by FACS. 47 pts were transplanted from matched related donors, 40

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Goncharova, Ekaterina V., Inga E. Zavodova, Nikita P. Volkov, et al. "Clinical efficiency and safety of tramadol and low-dose morphine to manage pain syndromes in children following chemotherapy and hematopoietic stem cell transplantation." Cellular Therapy and Transplantation 9, no. 2 (2020): 20–27. http://dx.doi.org/10.18620/ctt-1866-8836-2020-9-2-20-27.

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A sufficient subgroup of patients encounters pain syndrome in the course of cytostatic chemotherapy (ChT), either with or without hematopoietic stem cell transplantation (HSCT). Over this time period, severe thrombocytopenia and leucopenia may develop, thus limiting the opportunities for non-steroidal anti-inflammatory drugs (NSAID). As recommended by WHO, administration of strong opioids to children is possible in moderate pain and inefficiency of NSAIDs. In this case, second step of the pain relief ladder is absent, i.e., codeine application. However, the recommendations do not exclude usage

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Markiewicz, Miroslaw, Monika Dzierzak-Mietla, Patrycja Zielinska, et al. "Favorable Results of Allo-HSCT from MRD in Patients with Myelofibrosis." Blood 124, no. 21 (2014): 5934. http://dx.doi.org/10.1182/blood.v124.21.5934.5934.

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Abstract Introduction: Myelofibrosis (MF), chronic myeloid malignancy associated with shortened survival, in majority of patients develops de novo as Primary MF, but also polycythemia vera (PV) or essential thrombocythemia (ET) may progress into post-PV or post-ET MF. Although management of MF includes several treatment options, the only potentially curative treatment approach in MF is allogeneic hematopoietic stem cell transplantation (allo-HSCT). Aim of this study was to evaluate the results of allo-HSCT in patients with MF treated in Katowice, Poland. Material and Methods: 27 pts (14 male a

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Brunstein, Claudio G., Navneet Majhail, Daniela C. Setubal, et al. "The Predictive Value of the Hematopoietic Cell Transplantation (HCT)-Specific Comorbidity Index (CI) in Recipients of Umbilical Cord Blood (UCB) Transplantation." Blood 110, no. 11 (2007): 5065. http://dx.doi.org/10.1182/blood.v110.11.5065.5065.

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Abstract The hematopoietic cell transplantation (HCT)-specific comorbidity index (CI) has been shown to predict nonrelapse mortality (NRM) and overall survival (OS) after sibling and unrelated adult volunteer donor transplantation (Sorror Blood 2005, 106:2912). We retrospectively studied the predictive value of the HCT-CI in a cohort of 182 patients who underwent an umbilical cord blood (UCB) transplant for advanced or high risk malignancy at the University of Minnesota, between August 2001 and May 2006. Patients receive either a myeloablative (MA, n=54) or nonmyeloablative (NST, n=128) condit

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van Velzen-Ball, Lynne Margaret, Marie Ester Bernado, Franco Locatelli, et al. "Co-Transplantation of Haploidentical Bone Marrow Derived Mesenchymal Stem Cells Overcomes Graft Dysfunction and Improves Hematological and Lymphocyte Recovery in Haploidentical Stem Cell Transplantation." Blood 108, no. 11 (2006): 3118. http://dx.doi.org/10.1182/blood.v108.11.3118.3118.

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Abstract Haploidentical peripheral blood stem cell transplantation from a parent is an accepted form of therapy in children lacking a suitable donor who require stem cell transplantation. The risk of graft failure/rejection increases with the intense T cell depletion resulting from positive CD34 selection. Mesenchymal stem cells (MSCs) isolated from bone marrow can be expanded to sufficient numbers for clinical use. MSCs can improve hematological recovery but their role in overcoming graft dysfunction post transplant is unknown. We present results of co-transplantation of MSCs in children unde

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Kolmachikhina, E. B., T. N. Lugovitskaya, M. A. Tret’yak, and K. D. Naumov. "Physical and chemical regularities of zinc sulfide concentrate pressure leaching in the presence of lignosulfonate." Izvestiya Vuzov. Tsvetnaya Metallurgiya (Universities' Proceedings Non-Ferrous Metallurgy) 27, no. 5 (2021): 13–24. http://dx.doi.org/10.17073/0021-3438-2021-5-13-24.

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The study covers physical and chemical regularities of zinc sulfide concentrate oxygen pressure leaching in sulfuric acid. The effect of lignosulfonate concentration (CLSN = 0.2÷0.8 g/dm3), leaching time (τ = 20÷120 min), temperature (T = 393÷423 K), and oxygen partial pressure (РО2= 0.3÷0.7 MPa) on the degree of zinc and iron extraction into the solution and on the cake grain-size distribution was established. It was shown that lignosulfonate additive intensifies zinc and iron extraction into the solution. Maximum extraction of zinc and iron was 89 and 37 %, respectively, for 120 min of leach

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Schmidt, R. A., C. A. Troendle, and J. R. Meiman. "Sublimation of snowpacks in subalpine conifer forests." Canadian Journal of Forest Research 28, no. 4 (1998): 501–13. http://dx.doi.org/10.1139/x98-033.

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This effort to improve prediction of forest snowpack evaporation was aimed at understanding differences in winter snowpack among forested aspects. Theoretical arguments combined air temperature, humidity, wind speed, and radiation into a sublimation index. Monitoring weather factors and the mass of a 65-cm-diameter pan of snow set in a forest snowpack provided calibration of the index. Changes in snow surface structure caused a decrease with time in the empirical ratio of snowpack-to-index sublimation. This decrease was proportional to total sublimation since snowfall. We applied the model to

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Lysko, S. B., A. V. Portianko, M. V. Zadorozhnaya, and A. P. Krasikov. "APPLICATION OF PROPOLIS TINCTURE TO PREVENT INFECTIONS OF BROILERS." Bulletin of NSAU (Novosibirsk State Agrarian University), no. 1 (March 27, 2019): 139–47. http://dx.doi.org/10.31677/2072-6724-2019-50-1-139-147.

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Scientific and industrial experiment was carried out at the poultry farming on Ross308 broilers. The authors explored various schemes of application of propolis tincture for pre venting respiratory infection of poultry of bacterial etiology. The researchers arranged a control group and two experimental groups according to the principle of analogues. The groups were placed in separate isolated poultry houses. Chickens of the control group were fed with antibiotic Tilmipool (0.3 ml/l of water) aged 1-3; 14-16; 25-27 days; their poultry house was sprayed with Ecocide C (0.5%, 1 l/100 m3, exposure

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Ringdén, O., M. Remberger, V. Runde, et al. "Peripheral Blood Stem Cell Transplantation From Unrelated Donors: A Comparison With Marrow Transplantation." Blood 94, no. 2 (1999): 455–64. http://dx.doi.org/10.1182/blood.v94.2.455.

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Abstract Peripheral blood stem cell (PBSC) transplants from HLA-A, -B, and -DR compatible unrelated donors (n = 45) were compared with bone marrow (BM; BM group, n = 45). Eighteen patients received CD34-selected PBSC (CD34 group). The PBSCs contained more mononuclear cells, CD34+, CD3+, and CD56+cells compared with marrow (P &lt; .001). Engraftment was achieved in all 45 patients in the BM group, in 43 of 45 (95%) in the PBSC group, and in 14 of 18 (78%) in the CD34 group (P &lt; .01). In multivariate analysis, a short time to absolute neutrophil count (ANC) equal to 0.5 × 109/L was as

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Ringdén, O., M. Remberger, V. Runde, et al. "Peripheral Blood Stem Cell Transplantation From Unrelated Donors: A Comparison With Marrow Transplantation." Blood 94, no. 2 (1999): 455–64. http://dx.doi.org/10.1182/blood.v94.2.455.414k08_455_464.

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Peripheral blood stem cell (PBSC) transplants from HLA-A, -B, and -DR compatible unrelated donors (n = 45) were compared with bone marrow (BM; BM group, n = 45). Eighteen patients received CD34-selected PBSC (CD34 group). The PBSCs contained more mononuclear cells, CD34+, CD3+, and CD56+cells compared with marrow (P < .001). Engraftment was achieved in all 45 patients in the BM group, in 43 of 45 (95%) in the PBSC group, and in 14 of 18 (78%) in the CD34 group (P < .01). In multivariate analysis, a short time to absolute neutrophil count (ANC) equal to 0.5 × 109/L was associated with the

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Sherry, Aron P., Natalie Pearson, Nicola D. Ridgers, et al. "activPAL-measured sitting levels and patterns in 9–10 years old children from a UK city." Journal of Public Health 41, no. 4 (2018): 757–64. http://dx.doi.org/10.1093/pubmed/fdy181.

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Abstract Background There is insufficient evidence of sitting time in UK children from validated objective measures. This study explored sitting patterns in primary school children from Bradford, UK, using the validated activPAL inclinometer. Methods Overall, 79 children (9.8 (SD 0.3) years old, 52% boys; 70% South Asian) wore activPALs for 7 days. Total sitting time, sitting time accumulated in different bout lengths, and the proportion of wear time spent in these variables were explored and compared across different periods of the week. Results Children spent 614 ± 112 (median ± IQR) min/day

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Clevenger, Christopher M., Pamela Parker Jones, Hirofumi Tanaka, Douglas R. Seals, and Christopher A. DeSouza. "Decline in insulin action with age in endurance-trained humans." Journal of Applied Physiology 93, no. 6 (2002): 2105–11. http://dx.doi.org/10.1152/japplphysiol.00315.2002.

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We tested the hypothesis that regular endurance exercise prevents the age-related decline in insulin action typically observed in healthy, sedentary adults. An index of whole body insulin sensitivity (ISI), obtained from minimal model analysis of insulin and glucose concentrations during a frequently sampled intravenous glucose tolerance test, was determined in 126 healthy adults: 25 young [27 ± 1 (SE) yr; 13 men/12 women] and 43 older (59 ± 1 yr; 20/13) sedentary and 25 young (29 ± 1 yr; 12/13) and 33 older (60 ± 1 yr; 20/13) endurance trained. ISI values were lower in the older vs. young adu

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Shah, Leena, Rachel Meislin, Jill Berkin, Gustavo Fernandez-Ranvier, and Maria Skamagas. "Adrenal Cushing’s in Pregnancy, Managed with Metyrapone to Optimize for Adrenalectomy at 27 Weeks Gestation." Journal of the Endocrine Society 5, Supplement_1 (2021): A109. http://dx.doi.org/10.1210/jendso/bvab048.219.

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Abstract Background: Cushing’s syndrome in pregnancy is associated with increased fetal and maternal morbidity and mortality. Prompt diagnosis and management during pregnancy is critical to improving these outcomes. Clinical Case: Patient is a 28-year-old female who presented to our hospital at 25 weeks of pregnancy with severe striae, high blood pressure, mildly elevated blood sugars and hypokalemia. Striae began in the 6th week of her pregnancy but progressed in the 2nd trimester to encompass multiple sections of skin. Blood pressure on presentation was 146/100 mmHg (on labetalol) and fastin

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Nicolaije, Kim A. H., Nicole P. M. Ezendam, M. Caroline Vos, et al. "Impact of an Automatically Generated Cancer Survivorship Care Plan on Patient-Reported Outcomes in Routine Clinical Practice: Longitudinal Outcomes of a Pragmatic, Cluster Randomized Trial." Journal of Clinical Oncology 33, no. 31 (2015): 3550–59. http://dx.doi.org/10.1200/jco.2014.60.3399.

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Purpose This study was conducted to longitudinally assess the impact of an automatically generated survivorship care plan (SCP) on patient-reported outcomes in routine clinical practice. Primary outcomes were patient satisfaction with information and care. Secondary outcomes included illness perceptions and health care use. Methods Twelve hospitals were randomly assigned to SCP care or usual care in a pragmatic, cluster randomized trial. Newly diagnosed patients with endometrial cancer completed questionnaires after diagnosis (n = 221; 75% response), 6 months (n = 158), and 12 months (n = 147)

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Rioux-Masse, B., J. Roy, R. Belanger, et al. "Autologous Bone Marrow Transplant after Failed Peripheral Blood Stem Cell Mobilization Does Not Adversely Affect Engraftment or Transplant Related Toxicity." Blood 106, no. 11 (2005): 2736. http://dx.doi.org/10.1182/blood.v106.11.2736.2736.

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Abstract Introduction: Chemotherapy and G-CSF are widely used to collect adequate numbers of peripheral blood stem cells (PBSC) prior to autologous transplant. However, 10–30% of patients (pts) will not mobilize adequately. Alternatives include use of stem cell factor (SCF) and bone marrow (BM) harvest. Limited information is available on the hematopoietic reconstitution and clinical outcome of intensively treated pts who fail to mobilize sufficient numbers of PBSC and receive BM grafts. We sought to determine whether BM is an acceptable source of stem cells in these pts. Methods: We conducted

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Kaya, Mehmet, Mutlu Küçük, Rivaze Bulut Kalayci, et al. "Magnesium sulfate attenuates increased blood-brain barrier permeability during insulin-induced hypoglycemia in rats." Canadian Journal of Physiology and Pharmacology 79, no. 9 (2001): 793–98. http://dx.doi.org/10.1139/y01-046.

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Magnesium probably protects brain tissue against the effects of cerebral ischemia, brain injury and stroke through its actions as a calcium antagonist and inhibitor of excitatory amino acids. The effects of magnesium sulfate on cerebrovascular permeability to a dye, Evans blue, were studied during insulin-induced hypoglycemia with hypothermia in rats. Hypoglycemia was induced by an intramuscular injection of insulin. After giving insulin, each animal received MgSO4 (270 mg/kg) ip, followed by a 27 mg/kg dose every 20 min for 2.5 h. Plasma glucose and Mg2+ levels of animals were measured. Magne

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San-Miguel, Jesùs F., Katja C. Weisel, Philippe Moreau, et al. "MM-003: A phase III, multicenter, randomized, open-label study of pomalidomide (POM) plus low-dose dexamethasone (LoDEX) versus high-dose dexamethasone (HiDEX) in relapsed/refractory multiple myeloma (RRMM)." Journal of Clinical Oncology 31, no. 15_suppl (2013): 8510. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.8510.

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8510 Background: RRMM patients (pts) who have exhausted treatment (Tx) with bortezomib (BORT) and lenalidomide (LEN) or thalidomide have a poor prognosis with short overall survival (OS). HiDEX is a well-established standard Tx in RRMM. POM has demonstrated clinical efficacy in pts refractory to LEN and BORT. MM-003 compared POM + LoDEX vs. HiDEX in RRMM pts who failed LEN and BORT and who progressed on their last Tx. Methods: Pts must have been refractory to last prior Tx (progressive disease [PD] during Tx or within 60 days) and failed LEN and BORT after ≥ 2 consecutive cycles of each (alone

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Joseph, Gregory, John Barnes, Eduardo Azziz-Baumgartner, et al. "Association of mRNA Vaccination With Clinical and Virologic Features of COVID-19 Among US Essential and Frontline Workers." JAMA 328, no. 15 (2022): 1523. http://dx.doi.org/10.1001/jama.2022.18550.

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ImportanceData on the epidemiology of mild to moderately severe COVID-19 are needed to inform public health guidance.ObjectiveTo evaluate associations between 2 or 3 doses of mRNA COVID-19 vaccine and attenuation of symptoms and viral RNA load across SARS-CoV-2 viral lineages.Design, Setting, and ParticipantsA prospective cohort study of essential and frontline workers in Arizona, Florida, Minnesota, Oregon, Texas, and Utah with COVID-19 infection confirmed by reverse transcriptase–polymerase chain reaction testing and lineage classified by whole genome sequencing of specimens self-collected w

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Broch, J., I. M. Da Silva, I. C. Pires Filho, et al. "Determinação dos valores energéticos e da composição química do resíduo seco de fecularia para frangos de corte." Archivos de Zootecnia 69, no. 267 (2020): 360–65. http://dx.doi.org/10.21071/az.v69i267.5355.

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O objetivo do trabalho foi determinar os valores energéticos e a composição química do resíduo seco de fecularia (RSF) para frangos de corte. Os tratamentos foram distribuídos em um delineamento experimental inteiramente casualizado, em um esquema fatorial 2x5, constituídos de dois sexos e cinco níveis de inclusão do RSF (0; 10; 20; 30 e 40%), totalizando dez tratamentos e quatro repetições, com quatro aves por unidade experimental. O período experimental teve duração de dez dias, sendo cinco dias de adaptação e cinco de coleta de excretas. As amostras de excretas, rações e RSF foram secas em

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