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Journal articles on the topic '159.93-055.2-057.17 (043.2)'

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Published: 30 May 2022

Last updated: 31 July 2025

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1

Semenova, Lioubov I., and Allan H. White. "Structural Systematics of Rare Earth Complexes. XIX (Hydrated) 1 : 2 Mononuclear Adducts of Lanthanoid(III) Chlorides with 2,2′-Bipyridine and 1,10-Phenanthroline." Australian Journal of Chemistry 52, no. 6 (1999): 571. http://dx.doi.org/10.1071/ch98052.

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Room-temperature single-crystal X-ray structure determinations are recorded for a number of adducts of hydrated lanthanoid(III) trichlorides with 2,2′-bipyridine (‘bpy’) and 1,10-phenanthroline (‘phen’), crystallized from water, methanol or ethanol solutions, containing mononuclear arrays with 1 : 2 Ln/bpy or phen stoichiometry. LaCl3/phen/H2O(1 : 3 : 9), [(phen)2La(OH2)5]Cl3.phen.4H2O, although of overall 1 : 3 LaCl3/phen stoichiometry, has a lattice phen; it is orthorhombic, Pnna, a 19·947(7), b 16·457(5), c 12·213(2) Å, Z = 4; conventional R on |F| was 0·030 for No 2567 ‘observed’ (I >3σ

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2

Bowmaker, Graham A., Frances M. M. Hannaway, Peter C. Junk, Aaron M. Lee, Brian W. Skelton, and Allan H. White. "Synthetic, Structural and Vibrational Spectroscopic Studies in Bismuth(III) Halide/N,N′-Aromatic Bidentate Base Systems. V Bismuth(III) Halide/N,N′-Bidentate Ligand (1 : 2) Systems." Australian Journal of Chemistry 51, no. 4 (1998): 331. http://dx.doi.org/10.1071/c97040.

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Syntheses and room-temperature single-crystal X-ray determinations are recorded for a number of adducts of BiX3/N,N′-bidentate 1 : 2 stoichiometry (N,N′-bidentate = 2,2′-bipyridine (bpy) or 1,10-phenanthroline (phen)). BiX3/bpy (1 : 2), X = Br, I, are isomorphous, monoclinic, P21/c, a ≈ 7·5, b ≈ 31, c ≈ 10·3 Å, β ≈ 113°, Z = 4; conventional R on |F| were 0·058, 0·055 for No 1744, 2068 independent ‘observed’ (I > 3σ(I)) reflections. BiCl3/phen (1 : 2) is monoclinic, P21/C, a 9·675(3), b 31·845(7), c 7·756(2) Å, β 109·94(2), Z = 4, R 0·071 for No 2537, while BiBr3/phen (1 : 2), also monoclini

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3

Bowmaker, Graham A., Frances M. M. Hannaway, Peter C. Junk, Aaron M. Lee, Brian W. Skelton, and Allan H. White. "Synthetic, Structural and Vibrational Spectroscopic Studies in Bismuth(III) Halide/N,N′-Aromatic Bidentate Base Systems. IV Bismuth(III) Halide/N,N′-Bidentate Ligand (1 : 1) Systems." Australian Journal of Chemistry 51, no. 4 (1998): 325. http://dx.doi.org/10.1071/c97039.

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Room-temperature single-crystal X-ray studies are recorded for a number of adducts of BiX3 and N,N′-bidentate ligand (2,2′-bipyridine (bpy) or 1,10-phenanthroline (phen)), devoid of coordinated solvent. BiBr3/bpy/MeCN (1 : 1 : 1) is triclinic P-1, a 12·129(2), b 9·955(4), c 7·748(1) Å, α 73·14(2), β 77·34(1), γ 69·79(2)°, Z = 2; conventional R on |F| was 0·036 for No 2252 independent ‘observed’ (I > 3σ(I)) reflections. The phen analogue is isomorphous, a 11·586(3), b 10·839(6), c 7·769(10) Å, α 73·70(7), β 76·67(7), γ 70·34(4)°, Z = 2, R 0·042 for No 800. BiI3/bpy (1 : 1) is triclinic, P-1,

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Hart, Robert D., Graham A. Bowmaker, John D. Kildea, Eban N. de Silva, Brian W. Skelton та Allan H. White. "Lewis-Base Adducts of Group 11 Metal(I) Compounds. LXIX Syntheses, Spectroscopy and Structural Systematics of Some (Solvated) 1 : 2 Binuclear Adducts of Copper(I) Compounds with Triphenylarsine, [(Ph3As)2Cu(μ-X)2Cu(AsPh3)2], X = Cl, Br, ONO2". Australian Journal of Chemistry 50, № 6 (1997): 604. http://dx.doi.org/10.1071/c96041.

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1 : 2 Adducts of copper(I) chloride and bromide with triphenylarsine have been obtained as chloroform- solvated dimers [(Ph3As)2Cu(µ-X)2Cu(AsPh3)2].2CHCl3, characterized by room-temperature single- crystal X-ray studies, monoclinic C 2/c, a ≈ 21·4, b ≈ 17·9, c ≈ 19·3 Å, β ≈ 92°, Z = 4 dimers, conventional R on F being 0·041 and 0·055 for No 3922 and 3130 independent ‘observed’ (I > 3σ(I)) reflections; the halogen atoms of the dimers are disposed on crystallographic 2 axes, together with the associated hydrogen-bonded pair of disordered chloroform molecules. The structures form an interestin

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5

Banshodani, Masataka, Hideki Kawanishi, Misaki Moriishi, Sadanori Shintaku, and Shinichiro Tsuchiya. "Impact of Hybrid Therapy Comprising Peritoneal Dialysis and Hemodialysis on Acute Cardiovascular Events." Blood Purification 47, no. 4 (2018): 330–36. http://dx.doi.org/10.1159/000495357.

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Background: The impact of hybrid therapy comprising peritoneal dialysis (PD) and hemodialysis on cardiovascular events in PD patients remains unclear. Objective: We aimed to evaluate the effect of hybrid therapy on cardiovascular events. Methods: A total of 93 PD patients undergoing hybrid therapy for ≥3 years were divided into 2 groups according to left ventricular ejection fraction (LVEF): lower ejection fraction (LEF [n = 29], LVEF < 60%) and normal ejection fraction (NEF [n = 64], LVEF ≥60%). Hospitalization rates and echocardiographic parameters were evaluated. Results: The 1-year hosp

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6

Sasaki, Koji, Nina Shah, Qaiser Bashir, et al. "Outcome of Patients with Light Chain Multiple Myeloma Compared to IgG/IgA Myeloma after Autologous Stem Cell Transplant." Blood 126, no. 23 (2015): 3194. http://dx.doi.org/10.1182/blood.v126.23.3194.3194.

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Abstract Introduction: High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (auto-HCT) is the standard of care for younger patients with newly diagnosed multiple myeloma (MM). In approximately 15% of MM patients the monoclonal (M) spike consists of k or l light chains only as opposed to heavy + light chains. It remains unclear whether light chain (LC) MM has a different prognosis compared to other monoclonal protein subtypes after an auto-HCT. Methods: We retrospectively analyzed 1067 patients with MM who underwent auto-HCT between January 1, 2004 and January 1

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Choueiri, Toni K., Todd Michael Bauer, Jaime R. Merchan, et al. "Updated results from the phase 2 LITESPARK-003 study of belzutifan plus cabozantinib in patients with advanced clear cell renal cell carcinoma (ccRCC)." Journal of Clinical Oncology 43, no. 5_suppl (2025): 549. https://doi.org/10.1200/jco.2025.43.5_suppl.549.

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549 Background: In the phase 2 LITESPARK-003 study (NCT03634540), belzutifan plus cabozantinib showed antitumor activity in patients with advanced ccRCC who were treatment-naive (cohort 1) or previously treated (cohort 2). We present updated results from cohorts 1 and 2 with a median follow-up of 34.4 months and 49.9 months, respectively. Methods: Eligible patients had advanced or metastatic ccRCC and ECOG performance status of 0 or 1. Cohort 1 included patients with no prior systemic therapy. Cohort 2 included patients who had received prior immunotherapy and ≤2 systemic regimens. Starting do

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Sasaki, Koji, Ildefonso Ismael Rodriguez-Rivera, Hagop M. Kantarjian, et al. "Correlation of Lymphocyte Count with Treatment Response to Tyrosine Kinase Inhibitors in Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase." Blood 124, no. 21 (2014): 4538. http://dx.doi.org/10.1182/blood.v124.21.4538.4538.

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Abstract Background: Total lymphocyte count (TLC) has been shown to correlate with outcomes in patients (pts) with acute leukemia. The clinical correlation to TLC in pts with chronic myeloid leukemia in chronic phase (CML-CP) who were treated with a tyrosine-kinase inhibitor (TKI) is unclear. Methods: Lymphocyte data in pts with newly diagnosed CML-CP who were enrolled in consecutive or parallel clinical trials with front-line imatinib (IM), nilotinib (Nilo), or dasatinib (Dasa) were collected at the time of diagnosis, and 3 and 6 months (M) after the start of TKI. Relative lymphocytrosis (RLC

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Lukyanchik, Yuliya D., Tatyana V. Chernysheva, Elena I. Malinina, et al. "Assessment of the heart rate variability and cardiac biomarkers in young athletes: a cross-sectional study." Almanac of Clinical Medicine 53, no. 1 (2025): 34–42. https://doi.org/10.18786/2072-0505-2025-53-003.

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Background: Active athletic activity can occasionally trigger the development of cardiovascular diseases, especially in highly dynamic sports. Athletes who perform their training in cold climatic conditions are at risk of exhaustion of the functional reserve of the body and the sports-associated overstrain. Aim: To determine the characteristics of heart rate variability (HRV) and cardiac biomarkers in young hockey and football players in the Far North, to search for predictors of pathological myocardial remodeling. Methods: This was an observational cross-sectional study in 160 boys aged 12 to

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von Segesser, L. K., T. Mihaljevic, M. Tönz, B. Leskosek, P. Pei, and M. Turina. "Heparin surface coated hard shell venous reservoirs: experimental evaluation ex vivo." International Journal of Artificial Organs 17, no. 12 (1994): 651–56. http://dx.doi.org/10.1177/039139889401701206.

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The present study was designed for ex vivo evaluation of a heparin coated hard shell venous reservoir in comparison to uncoated control reservoirs. An open chest bovine right heart bypass model (n=9, bodyweight 72 ± 6 kg) with passive blood drainage from the right atrium into the venous reservoir and active retransfusion into the pulmonary artery (roller pump) was selected for this purpose. Clear priming was used for the open perfusion circuit. No heparin was given before or during the evaluation period which was scheduled for 6 hours. Reservoir blood flow was at the beginning 3.5 ± 0.6 I/min

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Sun, Shibin, and Ali Liu. "Long-term follow-up studies of Gamma Knife surgery for patients with neurofibromatosis Type 2." Journal of Neurosurgery 121, Suppl_2 (2014): 143–49. http://dx.doi.org/10.3171/2014.8.gks141503.

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ObjectThe aim of this study was to evaluate long-term clinical outcomes after Gamma Knife surgery (GKS) for patients with neurofibromatosis Type 2 (NF2) and the role of GKS in the management of NF2.MethodsFrom December 1994 through December 2008, a total of 46 patients (21 male, 25 female) with NF2 underwent GKS and follow-up evaluation for at least 5 years at the Gamma Knife Center of the Beijing Neurosurgical Institute. GKS was performed using the Leksell Gamma Knife Models B and C. The mean age of the patients was 30 years (range 13–59 years). A family history of NF2 was found for 9 (20%) p

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Wasserman, D. H., D. B. Lacy, C. A. Colburn, D. Bracy, and A. D. Cherrington. "Efficiency of compensation for absence of fall in insulin during exercise." American Journal of Physiology-Endocrinology and Metabolism 261, no. 5 (1991): E587—E597. http://dx.doi.org/10.1152/ajpendo.1991.261.5.e587.

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To assess compensation for the absence of the exercise-induced fall in insulin, dogs underwent 150 min of treadmill exercise with insulin infused intraportally with (IC + Glc; n = 7) or without (IC; n = 6) glucose clamped. Glucose production (Ra), gluconeogenic conversion (Conv), and intrahepatic gluconeogenic efficiency (Eff) were assessed with tracers ([3H]glucose, [14C]alanine) and arteriovenous differences. Glucose fell by 6 +/- 4 and 11 +/- 2 mg/dl at 30 min of exercise and by 8 +/- 2 and 36 +/- 5 mg/dl at 150 min in IC + Glc and IC. Glucagon rose by 16 +/- 8 and 55 +/- 17 pg/ml by 30 min

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13

Patel, Anuj Bharatkumar, Vicky Mai, Lucia Caiano, et al. "Fatal Pulmonary Embolism, Fatal Bleeding and Intracranial Hemorrhage with Systemic and Catheter-Directed Thrombolysis in Intermediate-High and High-Risk Pulmonary Embolism: A Systematic Review with Meta-Analysis." Blood 142, Supplement 1 (2023): 2644. http://dx.doi.org/10.1182/blood-2023-182859.

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Background: Thrombolysis, either systemic (ST) or catheter-directed (CDT), may reduce mortality in patients with intermediate-high and high-risk pulmonary embolism (PE), but with an increased risk of major bleeding (MB). Moreover, uncertainties remain for other efficacy and safety outcomes, such as fatal PE, fatal bleeding, and intracranial hemorrhage (ICH). Aims: To evaluate fatal PE, fatal bleeding and ICH with ST and CDT in patients with intermediate-high and high-risk PE. Methods: We performed a systematic search in MEDLINE, EMBASE and Cochrane from inception to December 2022. Randomized t

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14

Yam, Clinton, Miral Patel, Jia Sun, et al. "Early on-treatment (on-Rx) tumor volume reduction (TVR) to predict response to the KEYNOTE-522 (KN-522) regimen in early stage triple negative breast cancer (TNBC)." Journal of Clinical Oncology 43, no. 16_suppl (2025): 592. https://doi.org/10.1200/jco.2025.43.16_suppl.592.

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592 Background: Monitoring clinical response by breast ultrasound (US) during neoadjuvant therapy is considered standard of care. We previously demonstrated that suboptimal on-Rx TVR after neoadjuvant doxorubicin and cyclophosphamide (AC) predicts non-pCR after sequential taxane-based chemo. However, it is unknown if on-Rx TVR has the similar predictive value in pts receiving the KN-522 chemo-immunotherapy regimen. Methods: Pts with early stage TNBC planned to receive the KN-522 regimen were enrolled on the prospective ARTEMIS trial (NCT02276443). Breast US was performed at baseline and after

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Adinolfi, A., S. Sirotti, G. Sakellariou, et al. "POS1141 ASSESSING RELEVANT JOINTS FOR MONITORING CPPD DISEASE: A SYSTEMATIC LITERATURE REVIEW OF IMAGING TECHNIQUES BY THE OMERACT ULTRASOUND – CPPD SUBGROUP." Annals of the Rheumatic Diseases 80, Suppl 1 (2021): 850.1–850. http://dx.doi.org/10.1136/annrheumdis-2021-eular.3153.

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Background:Imaging has been extensively used for the Calcium Pyrophosphate Deposition Disease (CPPD) diagnosis but the prevalence of joint calcifications at imaging in CPPD patients has not been thoroughly assessed.Objectives:This systematic literature review (SLR) is aimed to estimate the prevalence of calcium crystal deposition in peripheral joints by imaging in suspected or definite CPPD patients to establish relevant joints for CPPD monitoringMethods:After defining PICOs, Pubmed and Embase were searched from inception to October 2020 for identifying studies that evaluated the use of Conven

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16

King, Jennifer, Rebecca Hassoun, Sandra K. Althouse, et al. "Genomic alterations in metastatic renal cell carcinoma (mRCC): Impact on survival and clinical outcomes." Journal of Clinical Oncology 41, no. 6_suppl (2023): 700. http://dx.doi.org/10.1200/jco.2023.41.6_suppl.700.

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700 Background: Genomic alterations in RCC can serve as biomarkers for response to therapy. Wild type VHL has shown inferior response to VEGF inhibitors, while patients (pts) with mutated VHL have improved outcomes with immunotherapy (IO)/tyrosine kinase inhibitor (TKI) therapy. We describe the impact of genomic alterations on outcomes and response to front-line therapy. Methods: Pts with mRCC who underwent genomic sequencing between 2015-2022 at Indiana University and were treated with front-line therapy were included. Kaplan-Meier method was used to analyze progression free survival (mPFS) a

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Joh, Jae Won, Angel Callejas, Wendy Wong, Harvey Joel Cohen, Kari Nadeau, and Michael Jeng. "Role of Fas/FasL Pathway in Pediatric Idiopathic Neutropenia." Blood 110, no. 11 (2007): 3291. http://dx.doi.org/10.1182/blood.v110.11.3291.3291.

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Abstract Idiopathic neutropenia in children is marked by low neutrophil counts (<1500/ul) circulating in the peripheral blood in patients whose disease spontaneously develops unrelated to drugs, cancers, specific antibodies, or known genetic deficiencies. Neutrophils, PBMCs and plasma were purified/obtained from 24 subjects (n=17 acute and n=7 chronic) with idiopathic neutropenia, aged 3 months to 11 yrs. After screening a number of cytokines (IL-2, IL-4 IL-6, IL-8, IL-10, IFN-γ, TNF-α), growth factors (GCSF), cell death factors (Fas, FasL, Granzymes/Perforin), and chemokines (CCL5, XCL1, X

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18

Werner, Juliane, Stephanie Schaefer, Sandra Lange, et al. "Engraftment Effects of Intra Bone Marrow Compared to Intravenous Transplantation of Allogeneic Hematopoietic Stem Cells Following a Reduced Intensity Conditioning in a DLA-Identical Canine Littermate Model." Blood 124, no. 21 (2014): 1089. http://dx.doi.org/10.1182/blood.v124.21.1089.1089.

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Abstract Introduction: Successful engraftment following hematopoietic stem cell transplantation (HSCT) depends on factors like immunosuppression, graft composition and number of infused HSC. Whereas the immunosuppression as well as the type and composition of the graft are influenceable low numbers of available HSCs i.e. “weak grafts” remain a clinical challenge. Weak grafts are accompanied by increased graft failure rates and longer cytopenias associated with increased morbidity. Intra bone marrow (IBM) infusion of HSC might be an approach to overcome these problems. Studies in rodents demons

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Palandri, Francesca, Marta Sobas, Claire Harrison, et al. "Improvement in Serum Albumin As a Measure of Improved Metabolic Profile in Pacritinib-Treated Patients: A Retrospective Analysis of Patients Treated across Three Clinical Trials." Blood 144, Supplement 1 (2024): 3191. https://doi.org/10.1182/blood-2024-192908.

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Background: As an acute phase reactant and a marker of nutritional status, serum albumin is a prognostic marker in patients with myelofibrosis (MF), with levels tending to decrease over time. An unfavorable cachexia index, based on albumin &lt;4.3 g/dL and cholesterol &lt;122 mg/dL, is associated with inferior survival in patients with MF. [Tefferi A, et al. Blood Adv. 2018] Retrospective data in patients with MF suggest that the JAK1/2 inhibitor ruxolitinib is associated with increases in albumin and cholesterol. [Kuykendall AT, et al. JCO Precision Oncology, 2024]. However, ruxolitin

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Giné, Eva, Sílvia Beà, Alba Navarro, et al. "Risk of Central Nervous System (CNS) Involvement in Patients with Mantle Cell Lymphoma (MCL): Analysis of Clinico-Biological Factors in a Series of 283 Cases." Blood 124, no. 21 (2014): 1677. http://dx.doi.org/10.1182/blood.v124.21.1677.1677.

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Abstract Introduction: MCL is a mature B-cell neoplasm characterized by t(11;14) (q13;q32) and cyclin D1 (CCND1) overexpression. Molecular studies have revealed other alterations in cell-cycle regulation, DNA damage response and cell survival pathways, with a landscape of somatic mutations being recently identified. CNS involvement is a well known complication, occurring in 4-26% of MCL at five years, with an ominous significance. Although different clinical variables have been identified as risk factors for CNS infiltration, the biological parameters related to this complication have not been

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Cayuela, Jean-Michel, Paola Ballerini, Marina Romeo, et al. "Evaluation of Minimal Residual Disease (MRD) by Quantification of TEL-AML1 Transcripts Is a Powerful Prognostic Tool in Children with T(12;21) Positive Acute Lymphoblastic Leukemia (ALL)." Blood 104, no. 11 (2004): 322. http://dx.doi.org/10.1182/blood.v104.11.322.322.

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Abstract TEL-AML1 fusion transcripts are found in 25% of children with B-cell precursor ALL (BCP-ALL). From June 1993 to December 1999, 1195 children with BCP-ALL were included in the FRALLE 93 protocol. Out of these, 792 were evaluated for TEL-AML1 transcript expression. There is no difference in terms of initial features, DFS, EFS, survival between evaluated (792) and non evaluated (403) patients. Out of the 792 pts, 191 (24%) expressed TEL-AML1 transcripts at diagnosis. To assess the potential prognostic value of TEL-AML1 transcripts quantification, we have retrospectively analysed follow u

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Michallet, Mauricette, Quoc Hung Le, Marie Robin, et al. "Double Cord Blood Cell (CBC) Hematopoietic Stem Cell Transplantation after Standard or Reduced Intensity Conditioning: Report of the SFGMTC Registry." Blood 112, no. 11 (2008): 1972. http://dx.doi.org/10.1182/blood.v112.11.1972.1972.

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Abstract This analysis concerned 164 allogeneic HSCT after standard (Std) or reduced intensity conditioning (RIC) using double cord blood cells (CBC), reported to the SFGM-TC registry. There were 57 females (F) and 107 males (M) with a median age of 39.5 years (18–66). The diagnosis pretransplant were acute leukaemia: 93 (56 AML and 37 ALL), MDS: 9, MPS: 9 (CML: 4), CLL: 5, NHL: 18, HD: 7, MM: 13, AA: 7, other diseases: 3 (2 inborn errors and 1 solid tumour). The median interval between diagnosis and HSCT was 20.6 months (2.6–385.5). Among 154 evaluated patients (pts), disease status prior con

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Criscitiello, Carmen, Giuseppe Viale, Davide Disalvatore, et al. "Adverse prognostic impact of intratumor heterogeneous HER2 gene amplification in patients with breast cancer." Journal of Clinical Oncology 31, no. 15_suppl (2013): 617. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.617.

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617 Background: There is increasing recognition of the existence of intratumoral heterogeneity of the human epidermal growth factor receptor (HER2), which affects interpretation of HER2 positivity in clinical practice and may have implications for patient prognosis and treatment. Only patients (pts) with HER2 positivity - defined as 3+ by IHC or FISH amplified defined as a HER2 gene to chromosome 17 (HER2/CEP17) ratio ≥ 2.0 - are eligible to receive trastuzumab treatment. Limited information is available on the prognosis of pts with HER2 2+ or FISH test with a HER2/CEP17 ratio < 2.0. Method

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Abu-Khalaf, Maysa, Fnu Nikita, Ayako Shimada, et al. "Abstract P4-11-32: Change in body mass index in breast cancer survivors." Cancer Research 82, no. 4_Supplement (2022): P4–11–32—P4–11–32. http://dx.doi.org/10.1158/1538-7445.sabcs21-p4-11-32.

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Abstract Background: Obesity is associated with an increased risk of breast cancer recurrence and poor survival. Obesity rate in adults in the city of Philadelphia is high, with non-Hispanic blacks and Hispanics having the highest rates. We sought to evaluate changes in body mass index (BMI) in breast cancer survivors within the first 2 years from initial encounter for a breast cancer (BC) diagnosis (dx), and investigate factors that may correlate with a change in BMI. Methods: We identified 5,423 BC patients (pts) in our electronic medical record, (1/2015-present), using ICD-10 code C50.X. We

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Liu, Hsi-Che, Ting-Chi Yeh, Jen-Yin Hou, Kuan-Hao Chen, Ting-Huan Huang, and Der-Cherng Liang. "Triple Intrathecal Therapy Alone Was Delayed until the Disappearance of Blasts From Peripheral Blood in Children with Acute Lymphoblastic Leukemia: The Experience of a Single Hospital in Taiwan." Blood 120, no. 21 (2012): 3564. http://dx.doi.org/10.1182/blood.v120.21.3564.3564.

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Abstract Abstract 3564 Background The introduction of CNS-directed therapy had successfully improved the outcome of children with acute lymphoblastic leukemia (ALL). Pui et al. (N Engl J Med, 2009) demonstrated that with effective risk-adjusted systemic chemotherapy and intrathecal therapy initiated at diagnosis (Dx), cranial irradiation can be safely omitted from CNS-directed treatment in all children with newly diagnosed ALL. Manabe et al. (J Clin Oncol, 2001) reported a delay of diagnostic lumbar puncture (LP) and triple intrathecal therapy (TIT) after 1 week of prednisolone monotherapy. St

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Altarabsheh, Salah Eldien, Kevin L. Greason, Hartzell V. Schaff, et al. "Staged Balloon Aortic Valvuloplasty before Standard Aortic Valve Replacement in Selected Patients with Severe Aortic Valve Stenosis." Texas Heart Institute Journal 41, no. 2 (2014): 152–58. http://dx.doi.org/10.14503/thij-13-3298.

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This study evaluated preoperative balloon aortic valvuloplasty (BAV) as a technique to decrease aortic valve replacement (AVR) risk in patients who have severe symptomatic aortic valve stenosis with substantial comorbidity. We report the outcomes of 18 high-risk patients who received BAV within 180 days before AVR from November 1993 through December 2011. Their median age was 78 years (range, 51–93 yr), and there were 11 men (61%). The pre-BAV median calculated Society of Thoracic Surgeons Predicted Risk of Mortality (STS PROM) was 18.3% (range, 9.4%–50.7%). Preoperative left ventricular eject

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Celiento, Michele, Stefania Blasi, Andrea De Martino, Stefano Pratali, Aldo D. Milano, and Uberto Bortolotti. "The Mosaic Mitral Valve Bioprosthesis: A Long-Term Clinical and Hemodynamic Follow-Up." Texas Heart Institute Journal 43, no. 1 (2016): 13–19. http://dx.doi.org/10.14503/thij-14-4407.

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We reviewed the cases of 100 patients (mean age, 73 ± 10 yr; 64 men) who had mitral valve replacement with a Medtronic Mosaic porcine bioprosthesis from 1995 through 2011. The mean New York Heart Association (NYHA) class was 3 ± 0.7, and 52 patients were in atrial fibrillation. Prosthetic sizes were chiefly 27 mm (50 patients) and 29 mm (40 patients). Follow-up ended in December 2012 and is 97% complete, with a cumulative duration of 611 patient-years (mean duration, 6 ± 4.6 yr; maximum, 17.7 yr). The early mortality rate was 10% (6% in elective patients); late deaths occurred in 31 patients (

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Alipour, Sina, Heather Leitch, Linda M. Vickars, et al. "Richter Transformation of Chronic Lymphocytic Leukemia: Incidence, Risk Factors and Outcome." Blood 112, no. 11 (2008): 3179. http://dx.doi.org/10.1182/blood.v112.11.3179.3179.

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Abstract Richter transformation (RT) is a rare complication of chronic lymphocytic leukemia (CLL). There is little information in the literature about its risk and outcome. In this study we assessed the incidence, presenting characteristics and outcomes of patients (pts) with CLL who developed RT. An electronic database search of pts with CLL who presented at St Paul’s Hospital between 1969 and 2007 was performed. Among 465 pts with CLL, 24 pts (5%) developed RT. Presenting features included B-symptoms (17%), lymph node enlargement (58%), progressive cytopenia (29%), hypercalcemia (4%), and sp

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Castillo, Jorge J., Joshua Gustine, Andrew Keezer, et al. "Ibrutinib Dose Reduction Does Not Affect Progression-Free Survival in Patients with Waldenstrom Macroglobulinemia." Blood 132, Supplement 1 (2018): 1598. http://dx.doi.org/10.1182/blood-2018-99-111626.

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Abstract Introduction: Ibrutinib is an oral Bruton Tyrosine Kinase inhibitor, approved for the treatment of symptomatic Waldenstrom Macroglobulinemia (WM). MYD88 and CXCR4 mutations affect progression-free survival (PFS) in patients with WM. In some cases, ibrutinib dose reductions are needed for the management of toxicity. However, it remains unclear if ibrutinib dose reductions adversely affect PFS in WM patients. Methods: We evaluated 217 consecutive patients with the clinicopathological diagnosis of WM who were symptomatic and received treatment with ibrutinib. We analyzed relevant clinica

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Eghtedar, Alireza, Stefan Faderl, Hagop Kantarjian, et al. "Incidence of Secondary Neoplasms In Patients with Acute Promyelocytic Leukemia Treated with All-Trans-Retinoic Acid (ATRA) with Chemotherapy or with Arsenic Trioxide (ATO)." Blood 116, no. 21 (2010): 1085. http://dx.doi.org/10.1182/blood.v116.21.1085.1085.

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Abstract Abstract 1085 Background: Progress in the treatment of patients (pts) with acute promyelocytic leukemia (APL) with the use of modern all-trans retinoic acid (ATRA)-containing regimens has resulted in the majority of pts achieving long-term disease-free survival. There is little data on the incidence and patterns of secondary neoplasms in pts treated with these regimens. Objective: To compare the incidence of secondary neoplasms in pts with APL treated with two different ATRA-containing regimens. Methods: We retrospectively examined the charts of 160 pts with APL treated with ATRA plus

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Gruson, Berengere, Sarah Ivanoff, Céline Berthon, et al. "Rural but Not Urban AML Exhibit Cytogenetic and Molecular Characteristics of Therapy-Related AML." Blood 124, no. 21 (2014): 2353. http://dx.doi.org/10.1182/blood.v124.21.2353.2353.

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Abstract Background:There are few established risk factors for AML. Benzene, radiation, prior chemotherapy treatments for cancer, and cigarette smoking have been causally linked with AML. Few studies have shown that incidence rates are highest in the agricultural region and it has been hypothesized that farming and its related exposures (e.g., pesticides) may account for this increased risk. Nonetheless, there are no do data regarding clinical, cytogenetic and molecular differences between rural and urban area. The primary objective of this study is to look for cytogenetic features of rural pa

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Byrd, John C., Dariusz Woszczyk, Arpad Illes, et al. "A Phase (Ph) 2 Study of TL-895, a Highly Selective, Novel Covalent BTK Inhibitor (BTKi), in Patients (pts) with Treatment-Naïve (TN) and Relapsed/Refractory (R/R) BTKi-Naïve Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL)." Blood 142, Supplement 1 (2023): 4634. http://dx.doi.org/10.1182/blood-2023-186517.

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Background: Covalent BTKi have become the backbone of CLL/SLL therapy. Through improved target kinase selectivity, second generation BTKi offer improved safety with potentially better efficacy, yet compartmental clearance leading to complete remission (CR) remains elusive. TL-895 is a potent, second generation, irreversible, oral BTKi with best-in-class selectivity (Gulrajani 2023) over other second generation BTKi; which may lead to improved safety and clearance of leukemic disease to induce deeper and more durable responses. Methods: This multicenter Ph 2 study (NCT02825836) enrolled symptom

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Thompson, Leslie A., Katherine A. Guthrie, Lihua Elizabeth Budde, et al. "The Pre-Transplant Mantle Cell Lymphoma International Prognostic Index Predicts Overall and Progression-Free Survival Following High-Dose Therapy and Autologus Stem Cell Transplant for Mantle Cell Lymphoma." Blood 118, no. 21 (2011): 2026. http://dx.doi.org/10.1182/blood.v118.21.2026.2026.

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Abstract Abstract 2026 Background: High-dose therapy (HDT) and autologous stem cell transplantation (ASCT) is frequently employed to improve outcomes in patients with mantle cell lymphoma (MCL), yet results after transplant vary widely. We and others have shown that the Mantle Cell International Prognostic Index (MIPI) measured at diagnosis can predict overall survival (OS) after HDT and ASCT (Geisler, Blood 2010; Budde JCO 2011). Unfortunately, this approach is often limited at the time of transplant by the lack of available MIPI data from the time of diagnosis. Furthermore, the MIPI at diagn

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Lakshman, Arjun, Jithma P. Abeykoon, Shaji Kumar, et al. "Daratumumab-based combination therapies (DCT) in heavily-pretreated patients (pts) with relapsed and/or refractory multiple myeloma (RRMM)." Journal of Clinical Oncology 35, no. 15_suppl (2017): 8038. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.8038.

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8038 Background: Daratumumab-based Combination Therapies (DCT) with bortezomib (V)/ lenalidomide (R)/ pomalidomide (P) and dexamethasone (d) showed exceptional activity in RRMM in trials. Experience outside of trials since the approval of Daratumumab (D) in 2015 is limited. Methods: RRMM pts seen at Mayo Clinic, MN from 12/2015 -12/2016 were reviewed. Pts who received ≥ 1cycle of DCT were included. Time-to-event analyses were done from date of starting DCT. Common terminology criteria for adverse events v4.0 were used to grade toxicities. Results: Of 130 pts, 59% were males and median age at D

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O’Brien, Stephen G., François Guilhot, John M. Goldman, et al. "International Randomized Study of Interferon Versus STI571 (IRIS) 7-Year Follow-up: Sustained Survival, Low Rate of Transformation and Increased Rate of Major Molecular Response (MMR) in Patients (pts) with Newly Diagnosed Chronic Myeloid Leukemia in Chronic Phase (CMLCP) Treated with Imatinib (IM)." Blood 112, no. 11 (2008): 186. http://dx.doi.org/10.1182/blood.v112.11.186.186.

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Abstract Background: Based on results from the IRIS trial, IM is the standard of care for pts with newly diagnosed CML-CP. This report presents the 7 yr data update of IRIS to assess long term outcome, response rate, and safety in pts on primary IM therapy. Methods: 553 pts were randomly assigned to IM and evaluated for hematologic, cytogenetic and molecular responses, discontinuations/cross-over reasons, event-free survival (EFS), progression to accelerated-phase (AP) or blast crisis (BC) and OS. Events for EFS were defined as the first occurrence of any of the following during treatment: dea

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Li, Bing, Jinqin Liu, Shiqiang Qu, et al. "Colony-Forming Unit Cell (CFU-C) Assays in Myelodysplastic Syndrome." Blood 126, no. 23 (2015): 2874. http://dx.doi.org/10.1182/blood.v126.23.2874.2874.

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Abstract Introduction: The myelodysplastic syndromes (MDS) are a group of clonal diseases derived from hematopoietic stem cells (HSC). Colony-forming unit cell (CFU-C) assay is an effective method to study the number and the function of HSC in vitro. In this study, we focus on the characteristics and the prognostic value of CFU-C in patients with MDS. Patients and Method: CFU-C assays were performed according to the protocol of MethoCultTM H4435 Enriched (STEMCELL Technologies). A colony was defined as an aggregate of >40 cells. Clusters consisted of 4 to 40 cells. 560 consecutive newly-dia

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Corti, Chiara, Tianyu Li, Alyssa R. Martin, et al. "Abstract P5-10-17: Impact of Pathologic Response and Individual Prognosis After Neoadjuvant Treatment (NAT) in Patients (pts) with Early HER2+ and Triple-Negative Breast Cancer (TNBC)." Clinical Cancer Research 31, no. 12_Supplement (2025): P5–10–17—P5–10–17. https://doi.org/10.1158/1557-3265.sabcs24-p5-10-17.

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Abstract Background: Pathologic complete response (pCR) is prognostic in pts with early breast cancer (eBC). This study aims to assess individual prognostic factors for recurrence-free survival (RFS) and overall survival (OS) in pts with pCR vs residual disease (RD). Methods: This retrospective study included pts diagnosed at our institution with TNBC or HER2+ eBC who underwent surgery post-NAT and had available data for pCR/RD, RFS, OS. Clinical tumor size (cT), nodal status (cN), and subtype were evaluated as prognostic factors using Cox models and Kaplan-Meier method, in all pts and in pts

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Huber, Sandra, Stephan Hutter, Constance Regina Baer, et al. "Similarities and Differences of DNMT3A, TET2 and ASXL1 Mutations across Ccus, MDS and AML." Blood 144, Supplement 1 (2024): 1819. https://doi.org/10.1182/blood-2024-200561.

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Background: The most frequently mutated genes in clonal hematopoiesis (CH) occurring during aging are DNMT3A, TET2, and ASXL1 (DTA). DTA mutations (mut) also recurrently occur in overt myeloid malignancies. Aim: Analyze similarities and differences regarding incidence, co-aberrations and clonal hierarchy across CCUS, MDS and AML in patients with DTAmut. Methods: We analyzed 1,604 samples (received 2005-2021) of patients (median age: 71 years [2-93]; female: 42%) diagnosed with CCUS (n=222) or a non-therapy related myeloid malignancy (MDS: n=637; AML: n=745). All samples were analyzed by WGS (m

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de Snoo, F. A., M. Knauer, R. A. Bender, et al. "Outcome prediction by the 70-gene profile in the context of the National Comprehensive Cancer Network (NCCN) guidelines." Journal of Clinical Oncology 27, no. 15_suppl (2009): 535. http://dx.doi.org/10.1200/jco.2009.27.15_suppl.535.

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535 Background: According to the NCCN consensus guidelines molecular profiling for breast cancer prognosis may be used in patients with ER-positive, Her2-negative and LN-negative disease. Current proposed NCCN clinical risk assessment suggests adjuvant treatment for the majority of these patients. The 70-gene profile (MammaPrint) is validated as an independent prognostic indicator for patients with lymph node-negative and positive disease. Prognosis prediction by MammaPrint may be more suitable to indicate who needs adjuvant chemotherapy in addition to endocrine therapy. Methods: 566 tumor sam

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Maksymenok, O. V., O. M. Kyslykh, and T. A. Serheieva. "Prevalence of SARS-CoV-2 antibodies before COVID-19 pandemic among vulnerable population groups in Ukraine." Preventive Medicine. Theory and Practice 2, no. 6 (2024): 14–20. http://dx.doi.org/10.61948/prevmed-2024-2-14.

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S erological studies aimed at determining antibodies to SARS-CoV-2 (AВ-SARS-CoV-2) in the first stages of the pandemic became an effective tool for assessing the intensity of the epidemic process of COVID-19. Diagnostic kits were primarily intended to be used in studies (mainly sero-epidemiological) at the population level, and not for individual diagnosis of COVID-19 cases. However, for a correct assessment of the prevalence of AВ-SARS-CoV-2 during the epidemic period, it is advisable to operate with the initial data regarding the detection of the specified markers in the pre-epidemic period.

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Markell, S., T. Gulya, K. McKay, et al. "Widespread Occurrence of the Aecial Stage of Sunflower Rust Caused by Puccinia helianthi in North Dakota and Minnesota in 2008." Plant Disease 93, no. 6 (2009): 668. http://dx.doi.org/10.1094/pdis-93-6-0668c.

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Sunflower rust caused by Puccinia helianthi (Schw.) is widespread in North America and occurs annually on cultivated sunflower (Helianthus annuus L.) and wild annual and perennial Helianthus spp., although severity on the U.S. sunflower crop has been increasing in recent years (2). P. helianthi is a autoecious, macrocyclic rust, but the aecial stage is rarely observed in the field (1,3,4). In most years, the earliest appearance of sunflower rust in North Dakota (ND) and surrounding states usually occurs in early August as the uredinial stage. Initial inoculum can result from urediniospores tha

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Islam, Md Robiul, Thilina Jayarathne, Isobel J. Simpson, et al. "Ambient air quality in the Kathmandu Valley, Nepal, during the pre-monsoon: concentrations and sources of particulate matter and trace gases." Atmospheric Chemistry and Physics 20, no. 5 (2020): 2927–51. http://dx.doi.org/10.5194/acp-20-2927-2020.

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Abstract. The Kathmandu Valley in Nepal is a bowl-shaped urban basin that experiences severe air pollution that poses health risks to its 3.5 million inhabitants. As part of the Nepal Ambient Monitoring and Source Testing Experiment (NAMaSTE), ambient air quality in the Kathmandu Valley was investigated from 11 to 24 April 2015, during the pre-monsoon season. Ambient concentrations of fine and coarse particulate matter (PM2.5 and PM10, respectively), online PM1, inorganic trace gases (NH3, HNO3, SO2, and HCl), and carbon-containing gases (CO2, CO, CH4, and 93 non-methane volatile organic compo

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Elalfy, Mohsen Saleh, Shebl Said Shebl, Mohamed A. Badr, et al. "Frequency of Agranulocytosis and Mild Neutropenia During Deferiprone Therapy in Clinical Practice." Blood 120, no. 21 (2012): 996. http://dx.doi.org/10.1182/blood.v120.21.996.996.

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Abstract Abstract 996 The incidence of agranulocytosis during deferiprone (Ferriprox®) use has been reported in clinical trials where patients' neutrophil counts were generally monitored weekly and deferiprone was discontinued at the first sign of neutropenia (neutrophil count < 1.5 × 10 9/L), but the incidence in a less rigorously monitored environment is unknown. This observational, open label, prospective, multi-centre, non-interventional drug surveillance program was designed to assess how the safety of deferiprone therapy is monitored in clinical practice. All patients in the 15 partic

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Nazha, Aziz, David J. Seastone, Tomas Radivoyevitch, et al. "A Novel Prognostic Model in Heavily Treated Patients with Myelodysplastic Syndromes (MDS)." Blood 124, no. 21 (2014): 168. http://dx.doi.org/10.1182/blood.v124.21.168.168.

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Abstract Background The Revised International Prognostic Scoring System (IPSS-R) was developed to risk stratify untreated patients (pts) with MDS. It has since been validated in pts treated with a single line of drug therapy, and has been modified in untreated pts to include mutational data; however, these approaches do not reflect typical MDS pts who receive different types of treatment in different sequences. We propose a prognostic model that incorporates mutational data and predicts outcome in pts with primary and secondary MDS regardless of their initial or subsequent treatments. Methods

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Tulpule, Sameer, Nigel H. Russell, Jenny Byrne, et al. "High Absolute T Regulatory Cell Counts and Resistance of CD8 Central Memory Cells to Killing by Fludarabine Predicts for Poor Responses to DLI in the Context of a Pre-DLI Lymphoreduction Strategy." Blood 118, no. 21 (2011): 1912. http://dx.doi.org/10.1182/blood.v118.21.1912.1912.

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Abstract Abstract 1912 The response to donor leukocyte infusions (DLI) can be improved by the use of pre-DLI lymphoreduction. The mechanism underlying this is poorly explained. In order to investigate this further we examined the T cell subsets in patients entered into a clinical trial testing the utility of pre-DLI lymphoreduction using fludarabine. Inclusion criteria were: 1. mixed chimerism (MC) in whole blood (< 95% donor), 2. previous reduced intensity transplant for a haematological malignancy or failure to respond to a previous dose of DLI and 3. a lymphocyte count of >1.0 × 109/l

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Murciano-Goroff, Yonina R., Rebecca S. Heist, Yasutoshi Kuboki, et al. "Abstract CT028: A first-in-human phase 1 study of LY3537982, a highly selective and potent KRAS G12C inhibitor in patients with KRAS G12C-mutant advanced solid tumors." Cancer Research 83, no. 8_Supplement (2023): CT028. http://dx.doi.org/10.1158/1538-7445.am2023-ct028.

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Abstract Background: Mutations in KRAS are among the most frequent oncogenic drivers with the G12C mutation found in up to ~13% of NSCLC. LY3537982 is an oral, highly selective, and potent inhibitor of KRAS G12C, which preclinically delivers &gt;90% sustained target occupancy. We present the initial results from LOXO-RAS-20001, a phase 1 study of LY3537982 in patients (pts) with KRAS G12C-mutant advanced solid tumors (NCT04956640). Methods: LY3537982 monotherapy dose escalation followed a mTPI-2 method. Dose expansion cohorts included combinations with pembrolizumab (NSCLC) and cetuximab (

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Merli, Michele, Benedetta Bianchi, Lorenza Bertù, et al. "Clonal B-Cell Lymphocytosis with Mariginal-Zone Features: Comparison with Overt Splenic Marginal-Zone Lymphomas in 77 Patients from a Monocentric Series." Blood 134, Supplement_1 (2019): 4017. http://dx.doi.org/10.1182/blood-2019-130288.

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Diagnosis of non-CLL B Cell Chronic Lymphoproliferative Disorders (BCLPD), defined by the detection of peripheral blood (PB) B-Cell clone with flow cytometry (FC) Matutesscore≤3, is not an infrequent event in clinical daily practice. Only a portion of these cases may be actually classified according to the 2016 revision of WHO classification of lymphoid neoplasms, as in these cases a non-bone marrow (BM) tissue biopsy is rarely available due to "liquid-only disease" (BM, PB, splenomegaly) or difficult accessible sites. The two most likely diagnosis of BCLPD according to WHO 2016 are splenic ma

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Abd AL-Khaliq, Israa Mohammad. "Prevalence of parasitic infections in Al-Kindy Teaching Hospital and Medical City Teaching Hospital." Archives of Clinical and Experimental Pathology 3, no. 4 (2024): 01–06. https://doi.org/10.31579/2834-8508/033.

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Background: Intestinal parasitic infections including amoebiasis, blastocystosis, giardiasis, are all worldwide distribution with harmful effects, it is an important cause of morbidity and death rate in the poor countries. Objective: This study was done to collect information of the frequency of these diseases in some regions of Baghdad. Our objectives are to detect the frequency of human pathogenic parasites in some regions of Baghdad in stool samples of patients who would attend to AL-Kindy Teaching Hospital, Medical City Teaching Hospital and to determine the most common age group affected.

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DeAngelo, Daniel J., Jason Gotlib, Vinod Pullarkat, et al. "Apex Part 1: Updated Assessment of Bezuclastinib (CGT9486), a Selective KIT D816V Tyrosine Kinase Inhibitor, in Patients with Advanced Systemic Mastocytosis (AdvSM)." Blood 144, Supplement 1 (2024): 659. https://doi.org/10.1182/blood-2024-193678.

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Background: Systemic mastocytosis (SM) is a rare disease characterized by the abnormal accumulation of mast cells (MC). In about 95% of adult patients, SM is driven by a gain-of-function mutation (D816V) in exon 17 of KIT. Advanced SM (AdvSM) is a life-threatening form of SM and includes three subtypes: aggressive SM (ASM), SM with an associated hematologic neoplasm (SM-AHN), and mast cell leukemia (MCL). Bezuclastinib is an oral, potent, and selective tyrosine kinase inhibitor (TKI) with activity against KIT D816V that spares closely related kinases and has minimal brain penetration. Initial

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Hens, Luc, Nguyen An Thinh, Tran Hong Hanh, et al. "Sea-level rise and resilience in Vietnam and the Asia-Pacific: A synthesis." VIETNAM JOURNAL OF EARTH SCIENCES 40, no. 2 (2018): 127–53. http://dx.doi.org/10.15625/0866-7187/40/2/11107.

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Climate change induced sea-level rise (SLR) is on its increase globally. Regionally the lowlands of China, Vietnam, Bangladesh, and islands of the Malaysian, Indonesian and Philippine archipelagos are among the world’s most threatened regions. Sea-level rise has major impacts on the ecosystems and society. It threatens coastal populations, economic activities, and fragile ecosystems as mangroves, coastal salt-marches and wetlands. This paper provides a summary of the current state of knowledge of sea level-rise and its effects on both human and natural ecosystems. The focus is on coastal urban

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